35,274 results match your criteria Mechanical Low Back Pain


An observational study on trajectories and outcomes of chronic low back pain patients referred from a spine surgery division for chiropractic treatment.

Chiropr Man Therap 2019 5;27. Epub 2019 Feb 5.

1Integrative Spinal Research Group, Department of Chiropractic Medicine, Balgrist University Hospital, Forchstr. 340, 8008 Zurich, Switzerland.

Background: A close collaboration between surgeons and non-surgical spine experts is crucial for optimal care of low back pain (LBP) patients. The affiliation of a chiropractic teaching clinic to a university hospital with a large spine division in Zurich, Switzerland, enables such collaboration. The aim of this study was to describe the trajectories and outcomes of patients with chronic LBP referred from the spine surgery division to the chiropractic teaching clinic. Read More

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http://dx.doi.org/10.1186/s12998-018-0225-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362585PMC
February 2019

Unusual Route of Buprenorphine Administration: An Alternative Approach for Bypassing Adverse Drug Reactions.

Curr Ther Res Clin Exp 2019 18;90:17-19. Epub 2019 Jan 18.

Department of Research Methodology and Data Analysis Institute for Environmental Research, Tehran University of Medical Science, Tehran, Iran.

Tramadol abuse is a critical and growing health concern in Asia. In Iran, tramadol abuse arises most commonly as a result of self-medicating that leads to tramadol dependence. Buprenorphine, a partial agonist of mu opioid receptors approved for the treatment of tramadol dependence, is administered sublingually due to its extensive first-pass metabolism and resulting low oral bioavailability. Read More

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http://dx.doi.org/10.1016/j.curtheres.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360512PMC
January 2019

Anatomical study of the superior cluneal nerve and its related groove on the iliac crest.

World Neurosurg 2019 Feb 11. Epub 2019 Feb 11.

Seattle Science Foundation, Seattle, WA, USA; Department of Anatomical Sciences, St. George's University, Grenada, West Indies.

Superior cluneal nerve entrapment neuropathy is one cause of low back pain often referred to as "pseudosciatica." Studies have found that the superior cluneal nerve can arise variably from the T11 to L5. The osteofibrous tunnels formed by a groove on the iliac crest might compress the superior cluneal nerve. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.210DOI Listing
February 2019

Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain.

Pain 2019 Jan 3. Epub 2019 Jan 3.

Alan Edwards Centre for Research on Pain, McGill University, Montre[Combining Acute Accent]al, QC, Canada.

Chronic pain is a debilitating and poorly treated condition whose underlying mechanisms are poorly understood. Nerve injury and inflammation cause alterations in gene expression in tissues associated with pain processing, supporting molecular and cellular mechanisms that maintain painful states. However, it is not known whether transcriptome changes can be used to reconstruct a molecular pathophysiology of pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001471DOI Listing
January 2019

Are hybrid sit-stand postures a good compromise between sitting and standing?

Ergonomics 2019 Feb 14:1-36. Epub 2019 Feb 14.

a Department of Kinesiology , University of Waterloo , Waterloo , Ontario , Canada.

Potential alternatives for conventional sitting and standing postures are hybrid sit-stand postures (i.e., perching). Read More

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http://dx.doi.org/10.1080/00140139.2019.1577496DOI Listing
February 2019

Manipulative Therapies: What Works.

Am Fam Physician 2019 Feb;99(4):248-252

University of Florida, Gainesville, FL, USA.

Manipulative therapies include osteopathic manipulative treatment and many other forms of manual therapies used to manage a variety of conditions in adults and children. Spinal manipulative therapy may provide short-term improvement in patients with acute or chronic low back pain, comparable with other standard treatments. When compared with oral analgesics, cervical manipulation and/or mobilization appears to provide better short-term pain relief and improved function in patients with neck pain. Read More

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February 2019

O-arm Navigation Combined With Microscope-assisted MIS-TLIF in the Treatment of Lumbar Degenerative Disease.

Clin Spine Surg 2019 Feb 12. Epub 2019 Feb 12.

Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Study Design: This is a retrospective study.

Objective: The purpose of this study is to compare the clinical outcomes between O-arm navigation combined with microscope-assisted minimally invasive transforaminal lumbar interbody fusion (novel MIS-TLIF) and open-TLIF for the treatment of 1-level lumbar degenerative disease.

Summary Of Background Data: MIS-TLIF is becoming increasingly popular; however, the limited visualization may increase various surgical complications. Read More

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http://dx.doi.org/10.1097/BSD.0000000000000804DOI Listing
February 2019

Effectiveness of extracorporeal shock wave for low back pain: A protocol of systematic review.

Medicine (Baltimore) 2019 Feb;98(7):e14511

Second Ward of Orthopedis Department.

Background: Previous clinical trials have reported that extracorporeal shock wave (EPSW) can be used to treat low back pain (LBP), and have achieved satisfied effect. However, its effectiveness is still inconclusive. Thus, this systematic review will aim to assess the effectiveness and safety of EPSW for patients with LBP. Read More

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http://dx.doi.org/10.1097/MD.0000000000014511DOI Listing
February 2019

Gouty spondylodiscitis with lumbar vertebral body retrolisthesis: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14415

Orthopaedics Surgery Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.

Rationale: Gout occurs mainly in joints, but rarely in the spine. In the spine, urate crystals can cause intervertebral space instability but rarely lead to retrolisthesis. Here, we present an extremely rare disease with gout invaded the intervertebral disc with lumbar retrolisthesis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014415DOI Listing
February 2019

Evaluation of the efficacy of epiduroscopic adhesiolysis in failed back surgery syndrome

Turk J Med Sci 2019 Feb 11;49(1):249-257. Epub 2019 Feb 11.

Background/aim: We aimed to compare the results of the treatment of the patients with failed back surgery syndrome (FBSS) by mechanical lysis and steroid hylase injection via epiduroscopy due to their stabilization status and to detect the effect of pathological diagnostic markers on prognosis and ongoing treatment protocol.

Materials And Methods: Eighty-two patients with FBSS symptoms were included. Two groups were composed as group I (stabilized) and group II (nonstabilized). Read More

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http://dx.doi.org/10.3906/sag-1807-173DOI Listing
February 2019

'Everything we see is a perspective, not the truth'.

Ann Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine, Clinical immunology and Rheumatology services, Post Graduate Institute of Medical Education & Research, Chandigarh, Punjab, India.

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http://dx.doi.org/10.1136/annrheumdis-2019-215109DOI Listing
February 2019

How common is imaging for low back pain in primary and emergency care? Systematic review and meta-analysis of over 4 million imaging requests across 21 years.

Br J Sports Med 2019 Feb 13. Epub 2019 Feb 13.

Institute for Musculoskeletal Health, The University of Sydney, Sydney Medical School, School of Public Health, Sydney, New South Wales, Australia.

Objectives: To (1) estimate the proportion of patients seeking care for low back pain (LBP) who are imaged and (2) explore trends in the proportion of patients who received diagnostic imaging over time. We also examined the effect of study-level factors on estimates of imaging proportion.

Data Sources: Electronic searches of MEDLINE, Embase and CINAHL databases from January 1995 to December 2017. Read More

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http://dx.doi.org/10.1136/bjsports-2018-100087DOI Listing
February 2019

Quantitative diagnosis of osteoporosis using lumbar spine signal intensity in magnetic resonance imaging.

Br J Radiol 2019 Feb 13:20180774. Epub 2019 Feb 13.

1 Department of Radiology, Isfahan University of Medical Sciences , Isfahan , Iran.

Objective:: Osteoporosis is the most common metabolic bone disease that is not recognized in many elderly people. To determine the cause of low back pain, lumbosacral MRI is done for a large population who may not have gone under dual energy X-ray absorptiometry (DXA). The aim of this study was to predict bone density using lumbar spine signals in lumbosacral MRI in high risk patients for osteoporosis including post-menopausal females and calculate a threshold for a new quantitative MRI-based score to be used in estimation of lumbar spine bone mass density. Read More

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http://dx.doi.org/10.1259/bjr.20180774DOI Listing
February 2019

Chen-Style Tai Chi for Individuals (Aged 50 Years Old or Above) with Chronic Non-Specific Low Back Pain: A Randomized Controlled Trial.

Int J Environ Res Public Health 2019 Feb 12;16(3). Epub 2019 Feb 12.

Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai 200438, China.

Tai Chi (TC) can be considered safe and effective intervention to improve pain and pain-related functional disability. However, it is unclear that whether aging individuals with Chronic Non-Specific Low Back Pain (CNS-LBP) can achieve positive results. This study, therefore, attempted to explore the effects of TC on pain and functional disability in CNS-LBP patients aged 50 years old or above. Read More

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http://dx.doi.org/10.3390/ijerph16030517DOI Listing
February 2019

Treatment Effect Sizes for Pain and Disability Are Moderated by the Delivery Approach for Mechanical Diagnosis and Therapy in a Population With Low Back Pain: A Systematic Review With a Meta-Regression Approach.

J Orthop Sports Phys Ther 2019 Feb 13:1-40. Epub 2019 Feb 13.

Faculty of Medicine and Health Science, Macquarie University, North Ryde, Australia.

Study Design: Systematic review.

Background: Mechanical Diagnosis and Therapy (MDT) is a treatment-based classification system founded on three core principles; classification into diagnostic syndromes, classification-based intervention and appropriate application of force. Many randomized controlled trials have investigated the efficacy of MDT for low back pain (LBP); however, results have varied. Read More

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http://dx.doi.org/10.2519/jospt.2019.8734DOI Listing
February 2019

Hybrid Approach to Treatment Tailoring for Low Back Pain: A Proposed Model of Care.

Authors:
Paul W Hodges

J Orthop Sports Phys Ther 2019 Feb 13:1-37. Epub 2019 Feb 13.

The University of Queensland, School of Health and Rehabilitation Sciences, Brisbane, QLD, Australia.

Synopsis: Various approaches are used to guide treatment selection in low back pain. These have been considered in isolation and often tested against each other. An alternative view is that benefit may be gained from a model of care that involves a hybrid of approaches. Read More

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http://dx.doi.org/10.2519/jospt.2019.8774DOI Listing
February 2019

IgG4-Related Aortitis.

Eur J Case Rep Intern Med 2018 27;5(9):000881. Epub 2018 Sep 27.

Department of Internal Medicine, Centro Hospitalar Conde São Januário, Macau SAR.

Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory condition characterized by tumefactive lesions that can affect multiple organs. Serum IgG4 levels may be elevated. Early recognition is sometimes difficult but is important to avoid irreversible organ damage. Read More

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http://dx.doi.org/10.12890/2018_000881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346820PMC
September 2018

Successful Management of Prosthetic Valve Endocarditis with Antibiotherapy Alone.

Eur J Case Rep Intern Med 2018 24;5(4):000808. Epub 2018 Apr 24.

Internal Medicine Service, Centro Hospitalar Tondela-Viseu, E.P.E. - Viseu, Portugal.

Objectives: To report a case of mechanical aortic prosthesis endocarditis successfully treated with antibiotics alone.Materials and methods: We describe a clinical case and present a review of the literature.

Results: A 60-year-old female farmer with a mechanical aortic prosthetic valve presented with low back pain and fever. Read More

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http://dx.doi.org/10.12890/2018_000808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346756PMC

Low Back Pain: A Pain That May Not Be Harmless.

Eur J Case Rep Intern Med 2018 21;5(3):000834. Epub 2018 Mar 21.

Serviço de Medicina Interna B, Hospital Geral, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Abdominal aortic aneurysms are defined as vascular dilatations greater than 50% of the normal proximal segment or those that have a maximum diameter above 3 cm. Risk factors include male gender, age over 75 years, history of vascular pathology, hypertension and arteriosclerosis. The Authors describe a case of a 74-year-old man, evaluated in an emergency setting for right lumbar pain lasting 4 days. Read More

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http://dx.doi.org/10.12890/2018_000834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346959PMC

Study of the Prevalence of Dyspepsia in the Adult Population in a Rural Community of Bangladesh.

Mymensingh Med J 2019 Jan;28(1):163-174

Dr Jayanta Chowdhury, Assistant Professor, Department of Gastroenterology(Ex), Dhaka Medical College, Dhaka, Bangladesh.

Dyspepsia is a symptom complex that includes epigastric pain, post-prandial fullness, bloating, early satiety, belching, nausea, vomiting, heartburn, acid regurgitations and anorexia. The most widely applied definition of dyspepsia is the Rome working team formulation namely chronic or recurrent pain or discomfort centered in the upper abdomen. Till date the prevalence of dyspepsia in Bangladesh has not been studied much. Read More

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January 2019

Predictors of Participation in a Nonpharmacological Intervention for Chronic Back Pain.

Pain Med 2018 Sep;19(suppl_1):S76-S83

VA Connecticut Healthcare System, Pain Research, Informatics, Multimorbidities, and Education (PRIME) Health Services Research and Development Center of Innovation, West Haven, Connecticut.

Objective: Cognitive behavioral therapy for chronic pain (CBT-CP) has been identified as an evidence-based adjunct or alternative to opioid pain care. However, little is known about which patients participate in CBT-CP. This study examined predictors of enrollment in a noninferiority trial of in-person vs technology-based CBT-CP for patients with chronic back pain. Read More

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http://dx.doi.org/10.1093/pm/pny077DOI Listing
September 2018

Summit-07: A randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain.

Pain 2019 Feb 8. Epub 2019 Feb 8.

Gold Coast Research, LLC, Plantation, FL.

NKTR-181, a new molecular entity, full mu-opioid receptor agonist with an inherently slow rate of CNS entry, was designed to provide analgesia while reducing abuse potential. The objective of this phase 3, enriched-enrollment, randomized-withdrawal trial was to evaluate the analgesic efficacy, safety, and tolerability of NKTR-181 in patients with chronic low-back pain (CLBP). Adults with moderate-to-severe CLBP refractory to non-opioid analgesics achieving an analgesic NKTR-181 dosage (100-400 mg twice daily) during the open-label titration period were randomized to continued NKTR-181 treatment, double-blind, or switched to placebo. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001517DOI Listing
February 2019
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The medial temporal lobe in nociception: a meta-analytic and functional connectivity study.

Pain 2019 Feb 8. Epub 2019 Feb 8.

Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.

Recent neuroimaging studies implicate the medial temporal lobe (MTL) in nociception and pain modulation. Here, we aim to identify which subregions of the MTL are involved in human pain and to test its connectivity in a cohort of chronic low back pain patients (CBP). We conducted two coordinate-based meta-analyses to determine which regions within the MTL showed consistent spatial patterns of functional activation (1) in response to experimental pain in healthy participants, and (2) in chronic pain compared to healthy participants. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001519DOI Listing
February 2019
1 Read

Increased pain and sensory hyperinnervation of the ligamentum flavum in patients with lumbar spinal stenosis.

J Orthop Res 2019 Feb 12. Epub 2019 Feb 12.

Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, department of Internal medicine, University Hospital Regensburg.

Nociceptive sensory nerve fibers have never been investigated in the ligamentum flavum (LF) of patients with LSS. The aim was to analyze nociceptive sensory nerve fibers in the ligamentum flavum (LF) of patients with LSS. A prospective study in patients with lumbar spinal stenosis (LSS) undergoing invasive surgical treatment for lumbar spinal stenosis (LSS) with flavectomy was performed. Read More

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http://dx.doi.org/10.1002/jor.24251DOI Listing
February 2019

Researching the Appropriateness of Care in the Complementary and Integrative Health Professions: Part I.

J Manipulative Physiol Ther 2019 Feb 8. Epub 2019 Feb 8.

RAND Corporation, University of California Los Angeles, Southern California Health Sciences, Santa Monica, California.

Objectives: The purpose of this article is to report on the Center of Excellence for Research on Complementary and Alternative Medicine at RAND Corporation. The overall project examined the appropriateness of chiropractic spinal manipulation and mobilization for chronic low back pain and chronic cervical pain using the RAND and University of California Los Angeles Appropriateness Method, including patient preferences and costs, to acknowledge the importance of patient-centered care in clinical decision-making.

Methods: This article is a narrative summary of the overall project and its inter-related components (ie, 4 Research Project Grants and 2 centers), including the Data Collection Core, whose activities and learning will be the subject of a following series of methods articles. Read More

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http://dx.doi.org/10.1016/j.jmpt.2018.11.002DOI Listing
February 2019

Efficacy of a blended low-intensity internet-delivered psychological programme in patients with multimorbidity in primary care: study protocol for a randomized controlled trial.

BMC Psychiatry 2019 Feb 11;19(1):66. Epub 2019 Feb 11.

Primary Care Prevention and Health Promotion Research Network, RedIAPP, Madrid, Spain.

Background: The World Health Organization (WHO) has included comorbidity between depression and a chronic disease among the 10 leading global health priorities. Although there is a high prevalence of multimorbidity, health care systems are mainly designed for the management of individual diseases. Given the difficulty in delivering face-to-face psychological treatments, alternative models of treatment delivery have been proposed, emphasizing the role of technologies such as the Internet. Read More

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https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12888-019-2037-3DOI Listing
February 2019
2 Reads

Integrating Mobile-health, health coaching, and physical activity to reduce the burden of chronic low back pain trial (IMPACT): a pilot randomised controlled trial.

BMC Musculoskelet Disord 2019 Feb 11;20(1):71. Epub 2019 Feb 11.

Discipline of Physiotherapy, Faculty of Health Sciences, The University of Sydney, Sydney, Australia.

Background: Low back pain is one of the most prevalent musculoskeletal conditions and the highest contributor to disability in the world. It is characterized by frequent relapses leading to additional care-seeking. Engagement in leisure physical activity is associated with lower recurrences and better prognosis and potentially reduced care-seeking. Read More

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http://dx.doi.org/10.1186/s12891-019-2454-yDOI Listing
February 2019
2 Reads

The Prevalence of Asymptomatic Cervical and Lumbar Facet Arthropathy: A Computed Tomography Study.

Asian Spine J 2019 Feb 13. Epub 2019 Feb 13.

Department of Rehabilitation Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.

Study Design: Case control study.

Purpose: To determine the prevalence and degree of asymptomatic cervical and lumbar facet joint arthritis. We retrospectively reviewed 500 computed tomography (CT) scans of cervical facet joints obtained from 50 subjects. Read More

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http://asianspinejournal.org/journal/view.php?doi=10.31616/a
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http://dx.doi.org/10.31616/asj.2018.0235DOI Listing
February 2019
1 Read

Radiologic parameters of ankylosing spondylitis patients treated with anti-TNF-α versus nonsteroidal anti-inflammatory drugs and sulfasalazine.

Eur Spine J 2019 Feb 11. Epub 2019 Feb 11.

Department of Orthopaedic Surgery, Medical Research Institute, Pusan National University School of Medicine, 1-10 Ami-Dong, Seo-Gu, Busan, 49241, Republic of Korea.

Purpose: Limited data are available on the relationship between treatment agents and sagittal balance in ankylosing spondylitis (AS). We investigated radiological features related to treatment agents and compared sagittal balance between patients treated with anti-tumor necrosis factor-α (anti-TNF-α) and those treated with nonsteroidal anti-inflammatory drugs (NSAIDs) and sulfasalazine (SSZ).

Methods: We prospectively enrolled 133 consecutive AS patients. Read More

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http://dx.doi.org/10.1007/s00586-019-05912-7DOI Listing
February 2019
1 Read

Psoas Abscess with Septic Arthritis of the Hip in a Patient with Chronic Back Pain.

Am J Med Case Rep 2018 10;6(11):224-225. Epub 2018 Dec 10.

Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, United States-11203.

Psoas abscess is a rare clinical entity that requires early diagnosis and timely intervention to avoid serious complications of the disease. We report a case of psoas abscess that presented initially as low back pain then complicated with septic arthritis. We discuss the clinical diagnosis, intervention and follow up of the case along with review of the literature. Read More

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http://dx.doi.org/10.12691/ajmcr-6-11-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368174PMC
December 2018
1 Read

A Central Nervous System Tumor Mimicking a Lumbar Spine Pathology Causing Acute Foot Drop: A Case Report.

J Orthop Case Rep 2018 Sep-Oct;8(5):78-81

Department of Orthopedics, Rabin Medical Center, Hasharon Hospital, Petah-Tikva, Israel.

Introduction: Common causes for foot drop are peroneal mono-neuropathy or sciatic neuropathy and lumbar root compression. Central nervous system pathologies leading to isolated drop foot are rare etiologies with unknown incidence.

Case Report: Our patient had a brain tumor manifested as acute onset foot drop accompanied by low back pain, leading us to look for a lumbar pathology. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367298PMC
February 2019

Minimal physical therapy utilization compared with higher physical therapy utilization for patients with low back pain: a systematic review.

Physiother Theory Pract 2019 Feb 9:1-22. Epub 2019 Feb 9.

e Department of Physical Therapy , University of the Pacific, Thomas J Long School of Pharmacy and Health Sciences , Stockton , CA , USA.

Aim: Currently there is a large and perhaps unwarranted variation regarding physical therapy utilization for individuals with low back pain (LBP).  The purpose of this systematic review was to compare the effects of minimal physical therapy utilization/education (two visits or less) versus typical physical therapy utilization (three visits or more) on patient-important outcomes for patients with LBP.

Methods: Two independent reviewers searched Cochrane, Medline, CINAHL, Web of Science, and PEDro from database inception until March 2017. Read More

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http://dx.doi.org/10.1080/09593985.2019.1571135DOI Listing
February 2019

Emotional distress correlates among patients with chronic non-specific low back pain: A hierarchical linear regression analysis.

Pain Pract 2019 Feb 9. Epub 2019 Feb 9.

School of Nursing, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, China, 210023.

Background: Chronic low back pain (CLBP) has become a worldwide health concern, and emotional distress is an important issue for CLBP management. However, it remains poorly understood how emotional distress happens and develops. This study aimed to systematically explored the correlates of emotional distress of CLBP patients. Read More

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http://dx.doi.org/10.1111/papr.12772DOI Listing
February 2019
1 Read

Discussions on real-world acupuncture treatments for chronic low-back pain in older adults.

J Integr Med 2019 Jan 26. Epub 2019 Jan 26.

American TCM Association (ATCMA), Vienna, VA 22182, USA; Eastern Roots Wellness, PLC, McLean, VA 22101, USA.

Chronic low-back pain (CLBP) is one of the most common pain conditions. Current clinical guidelines for low-back pain recommend acupuncture for CLBP. However, there are very few high-quality acupuncture studies on CLBP in older adults. Read More

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http://dx.doi.org/10.1016/j.joim.2019.01.005DOI Listing
January 2019
1 Read

Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI).

Parkinsonism Relat Disord 2019 Jan 31. Epub 2019 Jan 31.

Northwestern University Feinberg School of Medicine, USA. Electronic address:

Objective: To determine the feasibility, safety and tolerability of lumbar punctures (LPs) in research participants with early Parkinson disease (PD), subjects without evidence of dopaminergic deficiency (SWEDDs) and healthy volunteers (HC).

Background: Cerebrospinal fluid (CSF) analysis is becoming an essential part of the biomarkers discovery effort in PD with still limited data on safety and feasibility of serial LPs in PD participants.

Design/methods: Parkinson's Progression Marker Initiative (PPMI) is a longitudinal observation study designed to identify PD progression biomarkers. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2018.12.025DOI Listing
January 2019
1 Read

A systematic comparative outcome analysis of surgical versus percutaneous techniques in the management of symptomatic sacral perineural (Tarlov) cysts: a meta-analysis.

J Neurosurg Spine 2019 Feb 8:1-12. Epub 2019 Feb 8.

OBJECTIVESymptomatic perineural or Tarlov cysts (TCs) are a rare cause of chronic low-back pain. Given the rarity of the disease, there is no literature consensus regarding the optimal management of these cysts.METHODSThe authors conducted a systematic comparative outcome analysis of symptomatic TCs treated with surgery (group A, 32 studies, n = 333) or percutaneous interventions (group B, 6 studies, n = 417) analyzing the demographic characteristics, baseline characteristics of the cysts, clinical presentations, types of interventions, complication rates, and the recurrence rate in both treatment groups. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18952DOI Listing
February 2019

Neuromuscular morphometric characteristics in low back pain with unilateral radiculopathy caused by disc herniation: An ultrasound imaging evaluation.

Musculoskelet Sci Pract 2019 Feb 1;40:80-86. Epub 2019 Feb 1.

Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address:

Background: Little is known about the neuromuscular morphometric characteristics in patients with sciatica.

Objective: To evaluate the possible changes of nerve and muscle structures in patients with low back pain with unilateral radiculopathy due to lumbar disc herniation by ultrasound imaging.

Design: A case-control observational study. Read More

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http://dx.doi.org/10.1016/j.msksp.2019.01.016DOI Listing
February 2019
1 Read

Exploratory study of adalimumab in twelve patients with chronic low back pain associated with Modic I changes.

Joint Bone Spine 2019 Feb 6. Epub 2019 Feb 6.

Department of rheumatology, HFR Fribourg-Cantonal Hospital, 1708 Fribourg, Switzerland.

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http://dx.doi.org/10.1016/j.jbspin.2019.01.024DOI Listing
February 2019

ISSLS Prize in Basic science 2019: Physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration.

Eur Spine J 2019 Feb 8. Epub 2019 Feb 8.

NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

Purpose: Chronic low back pain causes structural remodelling and inflammation in the multifidus muscle. Collagen expression is increased in the multifidus of humans with lumbar disc degeneration. However, the extent and mechanisms underlying the increased fibrotic activity in the multifidus are unknown. Read More

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http://dx.doi.org/10.1007/s00586-019-05902-9DOI Listing
February 2019
1 Read

Comparative analysis of the intervertebral disc signal and annulus changes between immediate and 1-year postoperative MRI after transforaminal endoscopic lumbar discectomy and annuloplasty.

Neuroradiology 2019 Feb 8. Epub 2019 Feb 8.

Spine Center, Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Purpose: Postoperative magnetic resonance imaging (MRI) after microdiscectomy for lumbar disc herniation frequently shows spinal canal compression by the remaining annulus, which gradually decreases over time. Transforaminal endoscopic lumbar discectomy (TELD) can remove the herniation with minimal trauma to surrounding soft tissue. We aim to identify this remodeling of annulus fibrosus and the change of disc signal after TELD. Read More

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http://link.springer.com/10.1007/s00234-019-02174-4
Publisher Site
http://dx.doi.org/10.1007/s00234-019-02174-4DOI Listing
February 2019
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Prevalence and factors associated with low back pain among health care workers in southwestern Saudi Arabia.

BMC Musculoskelet Disord 2019 Feb 8;20(1):56. Epub 2019 Feb 8.

Department of Family and Community Medicine, College of Medicine, King Khalid University, Abha, Saudi Arabia.

Background: The purpose was to measure the prevalence and related risk factors of low back pain (LBP) among health care workers (HCWs) at different levels of health care in southwestern Saudi Arabia.

Methods: A cross-sectional study using a self-administered questionnaire was conducted among HCWs providing primary, secondary and tertiary health care services in the Aseer region, southwestern Saudi Arabia. The questionnaire collected data regarding having LBP in the past 12 months, socio-demographics, work conditions and history of chronic diseases, regular physical exercise and overexertional back trauma. Read More

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http://dx.doi.org/10.1186/s12891-019-2431-5DOI Listing
February 2019
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Association Between Predeployment Optimism and Onset of Postdeployment Pain in US Army Soldiers.

JAMA Netw Open 2019 Feb 1;2(2):e188076. Epub 2019 Feb 1.

Positive Psychology Center, University of Pennsylvania, Philadelphia.

Importance: Pain after deployment is a major health care concern. While risk factors have been previously studied, few studies have explored protective factors.

Objective: To examine the prospective association between predeployment optimism and the onset of new pain after deployment in US Army soldiers. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.8076DOI Listing
February 2019

Percutaneous Endoscopic Lumbar Discectomy Assisted by O-Arm-Based Navigation Improves the Learning Curve.

Biomed Res Int 2019 10;2019:6509409. Epub 2019 Jan 10.

Department of Orthopaedics, The Second Affiliated Xinqiao Hospital of Army Medical University, Chongqing 400037, China.

Objective: There is a steep learning curve with traditional percutaneous endoscopic lumbar discectomy (PELD). The aim of this study is to assess the safety and efficacy of PELD assisted by O-arm-based navigation for treating lumbar disc herniation (LDH).

Methods: From September of 2017 to January of 2018, 118 patients with symptomatic LDH were enrolled in the prospective cohort study. Read More

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http://dx.doi.org/10.1155/2019/6509409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348841PMC
January 2019

An inadvertent subarachnoid injection reversed by cerebrospinal fluid lavage for the treatment of chronic low back pain: A case report.

Medicine (Baltimore) 2019 Feb;98(6):e14406

Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Rationale: We present a case of high spinal anesthesia after inadvertent injection of local anesthetics and corticosteroids into the subarachnoid space during attempted epidural injection. Cerebrospinal fluid (CSF) lavage is a suitable method for treatment.

Patient Concerns: A 45-year-old woman presented with posterior thigh, leg, and ankle pain for >6 months and was treated with epidural injection. Read More

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http://dx.doi.org/10.1097/MD.0000000000014406DOI Listing
February 2019
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A multicenter randomized controlled trial on the efficacy of intradiscal methylene blue injection for chronic discogenic low back pain: the IMBI study.

Pain 2019 Jan 3. Epub 2019 Jan 3.

Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center, Maastricht, the Netherlands.

A study published in PAIN in 2010 showed remarkable effects of intradiscal methylene blue (MB) injections compared with placebo on pain intensity in patients with chronic discogenic low back pain (CD-LBP). Both groups received lidocaine hydrochloride injections for pain associated with the procedure. We replicated the design of the previously published study and performed a multicenter, double-blind, randomized, placebo-controlled trial to assess whether the extraordinary effects of MB on pain intensity could be confirmed. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001475DOI Listing
January 2019

Changes in the Organization of the Secondary Somatosensory Cortex While Processing Lumbar Proprioception and the Relationship With Sensorimotor Control in Low Back Pain.

Clin J Pain 2019 Feb 5. Epub 2019 Feb 5.

KU Leuven Department of Rehabilitation Sciences, Tervuursevest 101, box 1501, 3001 Leuven, Belgium.

Objectives: Patients with non-specific low back pain (NSLBP) rely more on ankle compared to lower back proprioception during standing, perform sit-to-stand-to-sit (STSTS) movements slower, and exhibit perceptual impairments at the lower back. However, no studies investigated whether these sensorimotor impairments relate to a reorganization of the primary and secondary somatosensory cortices (S1 and S2) and primary motor cortex (M1) during proprioceptive processing.

Methods: Proprioceptive stimuli were applied at lower back and ankle muscles during functional magnetic resonance imaging (fMRI) in 15 patients with NSLBP and 13 controls. Read More

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http://dx.doi.org/10.1097/AJP.0000000000000692DOI Listing
February 2019

Joint Hypermobility Among Female Patients Presenting with Chronic Myofascial Pelvic Pain.

PM R 2019 Feb 6. Epub 2019 Feb 6.

Department of Obstetrics and Gynecology, Denver Health Medical Center, Denver, CO.

Background: Female chronic pelvic pain is estimated to affect up to 24% of adult women, many of whom have a component of myofascial pelvic pain. Although an association of joint hypermobility and pelvic pain has been hypothesized, limited data are available that estimate the prevalence of joint hypermobility in this population.

Objective: To estimate the prevalence of generalized hypermobility spectrum disorder (G-HSD) among female patients with chronic myofascial pelvic pain and examine the association between G-HSD and other frequent pelvic pain-associated complaints. Read More

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http://dx.doi.org/10.1002/pmrj.12131DOI Listing
February 2019
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Sacral Pedicle Stress Fracture in an African-American Male, Adolescent, Competitive Basketball and Track and Field Athlete with a Prior Femoral Physeal Injury: A Case Report.

PM R 2019 Feb 6. Epub 2019 Feb 6.

Division, Physical Medicine & Rehabilitation, Departments of Neurology and Orthopedic Surgery, Washington University School of Medicine, St. Louis, Missouri.

A sacral pedicle stress fracture is an uncommon source of low back pain in adolescent athletes. Given the extensive differential diagnosis of low back pain coupled with the fact that non- directed specific imaging can be normal, diagnosis can be delayed. We report the case of a 15- year-old African American male, dual-sport athlete who experienced low back pain from a sacral pedicle stress fracture. Read More

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http://dx.doi.org/10.1002/pmrj.12119DOI Listing
February 2019
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Baicalein Inhibits the IL-1β-Induced Inflammatory Response in Nucleus Pulposus Cells and Attenuates Disc Degeneration In vivo.

Inflammation 2019 Feb 7. Epub 2019 Feb 7.

Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Intervertebral disc degeneration (IDD) is widely considered one of the main causes of low back pain, which is a chronic progressive disease closely related to inflammation and degeneration of nucleus pulposus (NP) cells. Baicalein is a natural bioactive compound with anti-inflammatory effects in different diseases, including inhibition of the inflammatory response in chondrocytes, whose morphology and avascular supply are similar to those of NP cells. Therefore, we hypothesized that baicalein may have a therapeutic effect on IDD by suppressing the inflammatory response. Read More

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http://dx.doi.org/10.1007/s10753-019-00965-8DOI Listing
February 2019

ISSLS PRIZE IN CLINICAL SCIENCE 2019: clinical importance of trunk muscle mass for low back pain, spinal balance, and quality of life-a multicenter cross-sectional study.

Eur Spine J 2019 Feb 6. Epub 2019 Feb 6.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.

Study Design: A multicenter cross-sectional study.

Objectives: To clarify the relationship of trunk muscle mass with low back pain, spinal sagittal balance, and quality of life. Few reports have investigated the relationship of trunk muscle mass with lumbar spine function and spinal balance, and the clinical significance of trunk muscle mass remains unclear. Read More

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http://dx.doi.org/10.1007/s00586-019-05904-7DOI Listing
February 2019
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