29,147 results match your criteria Measles Rubeola


Measles Virus Infects and Programs MAIT Cells for Apoptosis.

J Infect Dis 2020 Jul 5. Epub 2020 Jul 5.

Department of Microbiology and Immunology, Western University, London, Canada.

Measles virus (MeV) binds, infects and kills CD150+ memory T-cells, leading to "immune amnesia". Whether MeV targets innate, memory-like T-cells is unknown. We demonstrate that human peripheral blood and hepatic MAIT and iNKT cells express surprisingly high levels of CD150, more than any other lymphocyte subsets, including central and effector memory T-cells. Read More

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http://dx.doi.org/10.1093/infdis/jiaa407DOI Listing

A microneedle patch for measles and rubella vaccination: a game changer for achieving elimination.

Curr Opin Virol 2020 Jul 1;41:68-76. Epub 2020 Jul 1.

Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA.

While morbidity and mortality associated with measles and rubella (MR) have dramatically decreased, there are still >100000 estimated deaths due to measles and an estimated 100000 infants born with congenital rubella syndrome annually. Given highly effective MR vaccines, the primary barrier to global elimination of these diseases is low vaccination coverage, especially among the most underserved populations in resource-limited settings. In contrast to conventional MR vaccination by hypodermic injection, microneedle patches are being developed to enable MR vaccination by minimally trained personnel. Read More

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http://dx.doi.org/10.1016/j.coviro.2020.05.005DOI Listing

Longitudinal Profiling of the Vaccination Coverage in Brazil Reveals a Recent Change in the Patterns Hallmarked by Differential Reduction Across Regions.

Int J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

Curso de Medicina, Faculdade de Tecnologia e Ciências (UniFTC), Salvador, Bahia, Brazil; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil; Multinational Organization Network Sponsoring Translational and Epidemiological Research(MONSTER), Salvador, Bahia, Brasil.

Objective: Vaccination coverage is decreasing worldwide, favoring potential reemergence of vaccine-preventable disease. Here, we performed a longitudinal characterization of the vaccination coverage in Brazil and compared the profiles between the distinct regions in the country to test whether there has been a substantial change over the last five years.

Methods: We retrieved de-identified data publicly available from the repository of the Brazilian Ministry of Health, comprising detailed information on vaccination coverage, in all age groups, between 1994 and 2019. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326384PMC

A Measles outbreak in the Tel Aviv District, Israel, 2018-2019.

Clin Infect Dis 2020 Jul 3. Epub 2020 Jul 3.

Tel Aviv District Health Office, Ministry of Health, Israel.

During a national measles outbreak in 2018-2019, the Tel Aviv District suffered a major upsurge of cases, with 413 patients reported. Among them, 100 (24%) were under the age of one, 92 (22%) patients were aged 12 months to 4 years, 47 (11%) were 5-18 years, 169 (41%) were aged 19-60 years, 5 (1%) patients were older than 61 years (born before 1957). Among all cases, 230 (56%) were part of the Ultra-Orthodox Jewish community, 55 (13%) were among undocumented African immigrants. Read More

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http://dx.doi.org/10.1093/cid/ciaa931DOI Listing

Seroprevalence of Measles, Rubella, Tetanus, and Diphtheria Antibodies among Children in Haiti, 2017.

Am J Trop Med Hyg 2020 Jul 6. Epub 2020 Jul 6.

Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, Georgia.

In Haiti, measles, rubella, and maternal and neonatal tetanus have been eliminated, but a diphtheria outbreak is ongoing as of 2019. We conducted a national representative, household-based, two-stage cluster survey among children aged 5-7 years in 2017 to assess progress toward maintenance of control and elimination of selected vaccine-preventable diseases (VPDs). We stratified Haiti into west region (west department, including the capital city) and non-west region (all other departments). Read More

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http://dx.doi.org/10.4269/ajtmh.20-0112DOI Listing

The Practice Guideline for Vaccinating Korean Patients with Autoimmune Inflammatory Rheumatic Disease.

Infect Chemother 2020 Jun;52(2):252-280

Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju, Korea.

To develop a clinical practice guideline for vaccination in patients with autoimmune inflammatory rheumatic disease (AIIRD), the Korean College of Rheumatology and the Korean Society of Infectious Diseases developed a clinical practice guideline according to the clinical practice guideline development manual. Since vaccination is unlikely to cause AIIRD or worsen disease activities, required vaccinations are recommended. Once patients are diagnosed with AIIRD, treatment strategies should be established and, at the same time, monitor their vaccination history. Read More

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http://dx.doi.org/10.3947/ic.2020.52.2.252DOI Listing

Effects of COVID-19 Lockdown on Epidemic Diseases of Childhood.

J Med Virol 2020 Jul 3. Epub 2020 Jul 3.

School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

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http://dx.doi.org/10.1002/jmv.26253DOI Listing

Rapid diagnostic tests to address challenges for global measles surveillance.

Curr Opin Virol 2020 Jun 29;41:77-84. Epub 2020 Jun 29.

Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Recently, a lateral flow rapid diagnostic test (RDT) with good accuracy has been described. This test enables measles specific IgM antibody detection in serum, capillary blood and oral fluid. RDTs have the potential to transform measles surveillance by allowing real-time case confirmation outside of central/regional laboratories and by facilitating a timely public health response. Read More

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http://dx.doi.org/10.1016/j.coviro.2020.05.007DOI Listing

Modeling of the Transmission of Coronaviruses, Measles Virus, Influenza Virus, , and in Dental Clinics.

J Dent Res 2020 Jul 2:22034520940288. Epub 2020 Jul 2.

Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Dental health care workers are in close contact to their patients and are therefore at higher risk for contracting airborne infectious diseases. The transmission rates of airborne pathogens from patient to dental health care workers are unknown. With the outbreaks of infectious diseases, such as seasonal influenza, occasional outbreaks of measles and tuberculosis, and the current pandemic of the coronavirus disease COVID-19, it is important to estimate the risks for dental health care workers. Read More

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http://dx.doi.org/10.1177/0022034520940288DOI Listing

Prolonged maternal shedding and maternal-fetal transmission of measles virus.

Clin Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Institut Pasteur, Biology of Infection Unit, Paris, France.

Prolonged measles virus detection in maternal saliva and blood was evidenced in 6 pregnant women. Maternal-fetal transmission was evidenced in 2/4 infants who were asymptomatic at birth, 21-24 weeks after maternal infection. Whereas peripartum congenital measles is severe, asymptomatic measles virus vertical transmission can occur earlier in pregnancy. Read More

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http://dx.doi.org/10.1093/cid/ciaa915DOI Listing

A review of intralesional wart therapy.

Dermatol Online J 2020 Mar 15;26(3). Epub 2020 Mar 15.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC.

Background: New treatment options for warts include intralesional wart injection with agents such as vitamin D, measles, mumps, and rubella (MMR) vaccine antigen, Bacillus Calmette-Guerin (BCG) antigen, and candida antigen but there have been limited studies to compare their efficacies.

Objective: The purpose of this systematic review is to compare the efficacy and safety of injectable agents used for the treatment of warts.

Methods: A PubMed search included terms "intralesional wart therapy," "wart injection" and "verruca injection. Read More

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Prevalence and management of measles susceptibility in healthcare workers in Italy: a systematic review and meta-analysis.

Expert Rev Vaccines 2020 Jul 1. Epub 2020 Jul 1.

Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari , Bari, Italy.

Introduction: . The national and international guidelines recommend evaluating all healthcare workers (HCWs) for their measles immune status and possibly vaccinating those who are seronegative.

Areas Covered: . Read More

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http://dx.doi.org/10.1080/14760584.2020.1791091DOI Listing

The Cost-Effectiveness of Universal Varicella Vaccination in Italy: A Model-Based Assessment of Vaccination Strategies.

Clinicoecon Outcomes Res 2020 8;12:273-283. Epub 2020 Jun 8.

Center for Observational and Real-World Evidence, Merck & Co., Inc., Kenilworth, NJ, USA.

Background: In 2017, varicella vaccination became mandatory for all children in Italy, based on a two-dose schedule administered at 12-15 months of age and 5 to 6 years of age. Varicella vaccines are available in different formulations (as a single vaccine or as a combination vaccine together with measles, mumps, and rubella) and are made by multiple manufacturers with different effectiveness profiles. This study calculates the cost-effectiveness of a range of varicella vaccination strategies to identify the optimal strategy for Italy. Read More

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http://dx.doi.org/10.2147/CEOR.S229685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294569PMC

Modelling the Measles Outbreak at Hong Kong International Airport in 2019: A Data-Driven Analysis on the Effects of Timely Reporting and Public Awareness.

Infect Drug Resist 2020 17;13:1851-1861. Epub 2020 Jun 17.

Division of Biostatistics, JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, People's Republic of China.

Background: Measles, a highly contagious disease, still poses a huge burden worldwide. Lately, a trend of resurgence threatened the developed countries. A measles outbreak occurred in the Hong Kong International Airport (HKIA) between March and April 2019, which infected 29 airport staff. Read More

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http://dx.doi.org/10.2147/IDR.S258035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308762PMC

Incidence and Risk Factors for Severe Pneumonia in Children Hospitalized with Pneumonia in Ujjain, India.

Int J Environ Res Public Health 2020 Jun 27;17(13). Epub 2020 Jun 27.

Department of Pediatrics, Ruxmaniben Deepchand Gardi Medical College, Ujjain 456006, Madhya Pradesh, India.

Childhood pneumonia is a major public health problem. The aim of this prospective hospital-based study is to determine the incidence and risk factors for community-acquired severe pneumonia in children in Ujjain, India. The study includes 270 children, 161 (60%) boys and 109 (40%) girls, aged between 2 months and 5 years with World Health Organization defined and radiologically confirmed severe pneumonia. Read More

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http://dx.doi.org/10.3390/ijerph17134637DOI Listing

Investigation of Measles Outbreak among Thai and Migrant Workers in Two Factories in Nakhon Pathom, Thailand, 2019.

Int J Environ Res Public Health 2020 Jun 27;17(13). Epub 2020 Jun 27.

Division of Epidemiology, Department of Disease Control, Ministry of Public Health and Thailand, Nonthaburi 11000, Thailand.

On 22 March 2019 the Thai Department of Disease Control (DDC) was notified that 16 workers, including Thai and Myanmar migrant workers, from two factories located in Nakhon Phathom Province, had presented with a fever with rash during the previous 2 weeks. Active case finding was conducted among workers in both factories using face-to-face interviews. Suspected cases were defined as a worker who developed fever with rash with one of the following symptoms: cough, coryza or conjunctivitis. Read More

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http://dx.doi.org/10.3390/ijerph17134627DOI Listing

Probabilistic reconstruction of measles transmission clusters from routinely collected surveillance data.

J R Soc Interface 2020 Jul 1;17(168):20200084. Epub 2020 Jul 1.

Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

Pockets of susceptibility resulting from spatial or social heterogeneity in vaccine coverage can drive measles outbreaks, as cases imported into such pockets are likely to cause further transmission and lead to large transmission clusters. Characterizing the dynamics of transmission is essential for identifying which individuals and regions might be most at risk. As data from detailed contact-tracing investigations are not available in many settings, we developed an R package called to reconstruct the transmission clusters and the importation status of the cases from their age, location, genotype and onset date. Read More

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http://dx.doi.org/10.1098/rsif.2020.0084DOI Listing

A Rare Case of Measles-Associated Hemophagocytic Lymphohistiocytosis in an Infant.

Cureus 2020 May 23;12(5):e8246. Epub 2020 May 23.

Paediatrics, Penteli Children's Hospital, Athens, GRC.

Measles continues to be a threat in most European countries due to suboptimum vaccination coverage. Although measles leads to several complications, measles-related hemophagocytic lymphohistiocytosis (HLH) has been rarely reported. Herein, we present a case of a four-month-old male infant, the first child of unrelated, healthy parents, with no significant medical history or unexplained infant death in the family, otherwise healthy, who was diagnosed with measles-associated HLH and was successfully treated with IV dexamethasone and IV immunoglobulin (IVIG). Read More

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http://dx.doi.org/10.7759/cureus.8246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308916PMC

Paediatrics in Theresienstadt ghetto.

Cent Eur J Public Health 2020 Jun;28(2):155-160

Faculty of Education, Comenius University, Bratislava, Slovak Republic.

The main objective of this study is to describe the most common childhood diseases occurring in the Theresienstadt ghetto during the Second World War as well as applied anti-epidemic measures. A partial objective is to describe medical and nursing care of sick child prisoners. The data was obtained by the method of synthesis of primary and secondary data with the highest importance after adequate external source criticism using selected monographs, memoirs, survivor diaries, Orders of the day by the Council of the Elders and Reports of the Jewish self-government of the Theresienstadt ghetto from 1941 to 1945, the Archives of the Jewish Museum in Prague, the Ghetto Museum, the Museum of the History of Polish Jews in Warsaw, Post Bellum online electronic collection of oral historical interviews, and witness accounts. Read More

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http://dx.doi.org/10.21101/cejph.a5557DOI Listing

Vaccination rates for Syrian population under temporary protection in Turkey.

Cent Eur J Public Health 2020 Jun;28(2):130-134

Directorate General of Public Health, Ministry of Health, Ankara, Turkey.

Objectives: The aim of this study was to gather information on demographic and health indicators, primarily vaccination status, of Syrians under temporary protection in five provinces of Turkey and to develop infrastructure for vaccination planning.

Methods: The population under study consists of 89,986 Syrian children, 0-4 years of age, residing in Ankara, Mersin, Gaziantep, Izmir, and Bursa. Initially, we planned to evaluate 2,339 children, although a total of 2,827 children were evaluated by the end of the study. Read More

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http://dx.doi.org/10.21101/cejph.a5543DOI Listing
June 2020
0.798 Impact Factor

Valuation of a commercialized RT-PCR kit for the diagnosis of infection caused by the measles virus.

Enferm Infecc Microbiol Clin 2020 Jun 23. Epub 2020 Jun 23.

Consorcio de Investigación Biomédica de Epidemiología y Salud Pública (CIBERESP), España; Laboratorio de Referencia e Investigación en Enfermedades Víricas Inmunoprevenibles, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, España.

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http://dx.doi.org/10.1016/j.eimc.2020.05.014DOI Listing

The colliding epidemics of COVID-19, Ebola, and measles in the Democratic Republic of the Congo.

Lancet Glob Health 2020 Jun 23. Epub 2020 Jun 23.

National Institute of Biomedical Research and Department of Medical Microbiology and Virology, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

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http://dx.doi.org/10.1016/S2214-109X(20)30281-3DOI Listing

Mandatory vaccine policies associated with increased vaccination rates and decreased measles incidence.

J Pediatr 2020 Jul;222:253-257

Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1016/j.jpeds.2020.04.024DOI Listing

Surveillance system assessment in Guinea: Training needed to strengthen data quality and analysis, 2016.

PLoS One 2020 25;15(6):e0234796. Epub 2020 Jun 25.

RTI International, Research Triangle Park, North Carolina, United States of America.

The 2014-2016 Ebola virus disease outbreak revealed the fragility of the Guinean public health infrastructure. As a result, the Guinean Ministry of Health is collaborating with international partners to improve compliance with the International Health Regulations and work toward the Global Health Security Agenda goals, including enhanced case- and community-based disease surveillance. We assessed the case-based disease surveillance system during October 1, 2015-March 31, 2016, in the Boffa prefecture of Guinea. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234796PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316275PMC

Evaluation of vaccination coverage of measles-rubella campaign in Imphal East District, Manipur: A cross-sectional study.

Indian J Public Health 2020 Apr-Jun;64(2):173-177

PGT, Department of Community Medicine, Jawaharlal Nehru Institute of Medical Sciences, Imphal, Manipur, India.

Background: In India, the measles-rubella (MR) vaccination campaign was conducted with the purpose of vaccinating all children of 9 months-15 years of age with a single dose of MR vaccine. However, it encountered various challenges which may hamper with the coverage.

Objectives: This study was conducted to evaluate the recently conducted MR campaign in Manipur pertaining to its coverage and factors for not vaccinating. Read More

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http://dx.doi.org/10.4103/ijph.IJPH_361_19DOI Listing

Does Early Childhood Vaccination Protect Against COVID-19?

Front Mol Biosci 2020 5;7:120. Epub 2020 Jun 5.

Panevezys Faculty of Technology and Business, Kaunas Technology University (KTU), Panevezys, Lithuania.

The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the disease. This article aims at understanding why children constitute a minor group among hospitalized COVID-19 patients. Read More

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http://dx.doi.org/10.3389/fmolb.2020.00120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292051PMC

A Deep-Learning-Based Real-Time Detector for Grape Leaf Diseases Using Improved Convolutional Neural Networks.

Front Plant Sci 2020 3;11:751. Epub 2020 Jun 3.

Ningxia Smart Agricultural Industry Technology Collaborative Innovation Center, Yinchuan, China.

Black rot, Black measles, Leaf blight and Mites of grape are four common grape leaf diseases that seriously affect grape yield. However, the existing research lacks a real-time detecting method for grape leaf diseases, which cannot guarantee the healthy growth of grape plants. In this article, a real-time detector for grape leaf diseases based on improved deep convolutional neural networks is proposed. Read More

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http://dx.doi.org/10.3389/fpls.2020.00751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285655PMC

Limited Impact of Human Cytomegalovirus Infection in African Infants on Vaccine-Specific Responses Following Diphtheria-Tetanus-Pertussis and Measles Vaccination.

Front Immunol 2020 5;11:1083. Epub 2020 Jun 5.

Infant Immunology Group, Vaccines and Immunity Theme, MRC Unit, Fajara, Gambia.

Human cytomegalovirus (HCMV) infection has a profound effect on the human immune system, causing massive clonal expansion of CD8, and to a lesser extend CD4 T cells. The few human trials that have explored the effect of HCMV infection on responses to vaccination are conflicting, with some studies suggesting no effect whilst others suggest decreased or increased immune responses. Recent studies indicate substantial differences in overall immune system reactivity to vaccines based on age and sex, particularly cellular immunity. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291605PMC

The measles virus V protein binding site to STAT2 overlaps with that of IRF9.

J Virol 2020 Jun 24. Epub 2020 Jun 24.

Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan

Measles virus (MeV) is a highly immunotropic and contagious pathogen that can even diminish preexisting antibodies, and remains a major cause of childhood morbidity and mortality worldwide despite the availability of effective vaccines. MeV is one of the most extensively studied viruses with respect to mechanisms of JAK-STAT antagonism. Of the three proteins translated from the MeV gene, P and V are essential for inactivation of this pathway. Read More

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http://dx.doi.org/10.1128/JVI.01169-20DOI Listing

Molecular Epidemiology of B3 and D8 Measles Viruses through Hemagglutinin Phylogenetic History.

Int J Mol Sci 2020 Jun 22;21(12). Epub 2020 Jun 22.

Department of Biomedical Sciences for Health, University of Milan, via Carlo Pascal 36, 20133 Milan, Italy.

Of the 24 known measles genotypes, only D8 and B3 are responsible for outbreaks in the last years in Europe, Asia, and America. In this study the H gene of 92 strains circulating between 2015 and 2019 in Lombardy, Northern Italy, and 1273 H sequences available in GenBank were analyzed in order to evaluate the genetic variability and to assess the conservation of the immunodominant sites. Overall, in Lombardy we observed the presence of four different B3 and three different D8 clusters, each one of them including sequences derived from viruses found in both vaccinated and unvaccinated subjects. Read More

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http://dx.doi.org/10.3390/ijms21124435DOI Listing

A Novel Method to Identify Pneumonia through Analyzing Chest Radiographs Employing a Multichannel Convolutional Neural Network.

Sensors (Basel) 2020 Jun 19;20(12). Epub 2020 Jun 19.

School of Engineering, Deakin University, Geelong, VIC 3216, Australia.

Pneumonia is a virulent disease that causes the death of millions of people around the world. Every year it kills more children than malaria, AIDS, and measles combined and it accounts for approximately one in five child-deaths worldwide. The invention of antibiotics and vaccines in the past century has notably increased the survival rate of Pneumonia patients. Read More

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http://dx.doi.org/10.3390/s20123482DOI Listing

Measles (Rubeola): An Update.

J Spec Oper Med 2020 ;20(2):136-138

Measles is a significant concern with approximately 10 million people infected annually causing over 100,000 deaths worldwide. In the US before use of the measles vaccine, there were estimated to be 3 to 4 million people infected with measles annually, causing 400 to 500 deaths. Complications of measles include otitis media, diarrhea, pneumonia, and acute encephalitis. Read More

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January 2020

Structure, dynamics and phase separation of measles virus RNA replication machinery.

Curr Opin Virol 2020 Jun 19;41:59-67. Epub 2020 Jun 19.

Univ. Grenoble Alpes, CNRS, CEA, IBS, F-38000 Grenoble, France. Electronic address:

The measles virus replication complex represents a potentially important, but as yet relatively unexplored target for viral inhibition. Little is known about the molecular mechanisms that underpin replication and transcription in paramyxoviruses. In recent years it has become clear that conformational dynamics play an important role in paramyxoviral replication, and that a complete understanding of the viral cycle requires a description of the structural plasticity of the different components. Read More

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http://dx.doi.org/10.1016/j.coviro.2020.05.006DOI Listing

Measles immunity gaps in an era of high vaccination coverage: A serology study from Taiwan.

Travel Med Infect Dis 2020 Jun 19:101804. Epub 2020 Jun 19.

Department of Family Medicine, National Taiwan University Hospital, Bei-Hu, Taipei, Taiwan; Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan; Training Center for Travel Medicine, Taipei, Taiwan. Electronic address:

Background: Routine vaccination for children drastically reduces measles cases. Nonetheless, the global resurgence of measles since 2018 highlights the need for evaluating vaccine-induced immunity in an era of high vaccination coverage, especially in international travelers. This study aims to identify high-risk persons via analyzing the impact of age and different vaccination schedules on seroprevalence of measles in a country with high vaccination coverage, attempting to provide suggestions regarding pre-travel measles vaccination in highly immunized countries. Read More

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http://dx.doi.org/10.1016/j.tmaid.2020.101804DOI Listing

Can Users Search Trends Predict People Scares or Disease Breakout? An Examination of Infectious Skin Diseases in the United States.

Infect Dis (Auckl) 2020 8;13:1178633720928356. Epub 2020 Jun 8.

Jordanian Royal Medical Services, Amman, Jordan.

Background: In health and medicine, people heavily use the Internet to search for information about symptoms, diseases, and treatments. As such, the Internet information can simulate expert medical doctors, pharmacists, and other health care providers.

Aim: This article aims to evaluate a dataset of search terms to determine whether search queries and terms can be used to reliably predict skin disease breakouts. Read More

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http://dx.doi.org/10.1177/1178633720928356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285938PMC

[Imported B3 genotype measles virus isolated in Fujian province].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 Jun;41(6):946-951

Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Center for Disease Control and Prevention, Fuzhou 350001, China.

We isolated and identified the genotypes and molecular characteristics of the imported B3 measles virus (MeV) in Fujian province in 2018. Throat swab specimens were collected from clinically diagnosed measles patients and tested for viral RNA, using the real-time reverse transcription-polymerase chain reaction after the RNA extraction. Reverse transcription-polymerase chain reaction method was undertaken to amplify the 634 nucleotide acids of 3-terminal of the nucleoprotein gene. Read More

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http://dx.doi.org/10.3760/cma.j.cn112338-20190815-00599DOI Listing

Measles, mumps, rubella, and varicella-zoster virus serology and infections in solid organ transplant recipients during the first year post-transplantation.

Clin Infect Dis 2020 Jun 21. Epub 2020 Jun 21.

Viro-immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Mumps, measles, rubella, and varicella-zoster viruses (MMRV) may cause severe infections in seronegative adult solid organ transplant (SOT) recipients but can be prevented by vaccination. We aimed to determine MMRV serostatus in adult SOT recipients before and one-year post-transplantation as well as evidence of MMRV infections in a large, prospective cohort of SOT recipients.

Methods: A prospective study of 1182 adult SOT recipients included in the Management of Posttransplant Infections in Collaborating Hospitals (MATCH) cohort from 2011 to 2017 with a one-year follow-up. Read More

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http://dx.doi.org/10.1093/cid/ciaa824DOI Listing

Could an Unrelated Live Attenuated Vaccine Serve as a Preventive Measure To Dampen Septic Inflammation Associated with COVID-19 Infection?

mBio 2020 06 19;11(3). Epub 2020 Jun 19.

Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.

We propose the concept that administration of an unrelated live attenuated vaccine, such as MMR (measles, mumps, rubella), could serve as a preventive measure against the worst sequelae of coronavirus disease 2019 (COVID-19). There is mounting evidence that live attenuated vaccines provide nonspecific protection against lethal infections unrelated to the target pathogen of the vaccine by inducing "trained" nonspecific innate immune cells for improved host responses against subsequent infections. Mortality in COVID-19 cases is strongly associated with progressive lung inflammation and eventual sepsis. Read More

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http://dx.doi.org/10.1128/mBio.00907-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304316PMC

Measles surveillance in Canada: 2018.

Can Commun Dis Rep 2020 Apr 2;46(4):77-83. Epub 2020 Apr 2.

Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON.

Background: Measles has been eliminated in Canada since 1998. Every year, the Public Health Agency of Canada presents epidemiologic evidence to the Pan American Health Organization (PAHO) to verify that measles continues to be eliminated in Canada. The objectives of this article are to: provide an epidemiologic summary of measles activity reported in 2018 in Canada, and provide documented evidence to support the continued verification of measles elimination status in Canada. Read More

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http://dx.doi.org/10.14745/ccdr.v46i04a04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279125PMC

Vaccine acceptance: How to build and maintain trust in immunization.

Can Commun Dis Rep 2020 May 7;46(5):155-159. Epub 2020 May 7.

Quebec National Institute of Public Health, Québec, QC.

In Canada, over 80% of parents choose to vaccinate their children. Although this may appear positive, it is one of the lowest vaccination rates in the western world, and does not meet the 95% coverage rate needed to prevent outbreaks of vaccine-preventable diseases such as measles. A recent national immunization survey showed approximately 50% of parents are concerned about potential side-effects from vaccines, 25% believe that a vaccine can cause the disease it was meant to prevent, and 13% think alternative practices could eliminate the need for vaccines. Read More

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http://dx.doi.org/10.14745/ccdr.v46i05a09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279131PMC

Improving measles vaccine uptake rates in Nigeria: An RCT evaluating the impact of incentive sizes and reminder calls on vaccine uptake.

PLoS One 2020 18;15(6):e0233149. Epub 2020 Jun 18.

IDinsight, San Francisco, California, United States of America.

Objective: To assess the impact of increasing incentive size and reminder calls on the measles vaccine uptake rate.

Design: Randomized controlled trial, randomized at individual level, stratified by clinic.

Setting: Nigeria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233149PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302483PMC

Progress Toward Rubella Elimination - Western Pacific Region, 2000-2019.

MMWR Morb Mortal Wkly Rep 2020 Jun 19;69(24):744-750. Epub 2020 Jun 19.

Rubella is the leading vaccine-preventable cause of birth defects. Rubella typically manifests as a mild febrile rash illness; however, infection during pregnancy, particularly during the first trimester, can result in miscarriage, fetal death, or a constellation of malformations known as congenital rubella syndrome (CRS), commonly including one or more visual, auditory, or cardiac defects (1). In 2012, the Regional Committee of the World Health Organization (WHO) Western Pacific Region (WPR)* committed to accelerate rubella control, and in 2017, resolved that all countries or areas (countries) in WPR should aim for rubella elimination as soon as possible (2,3). Read More

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http://dx.doi.org/10.15585/mmwr.mm6924a4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302473PMC

Measles virus and rinderpest virus divergence dated to the sixth century BCE.

Science 2020 06;368(6497):1367-1370

Epidemiology of Highly Pathogenic Microorganisms Project Group, Robert Koch Institute, Berlin, Germany.

Many infectious diseases are thought to have emerged in humans after the Neolithic revolution. Although it is broadly accepted that this also applies to measles, the exact date of emergence for this disease is controversial. We sequenced the genome of a 1912 measles virus and used selection-aware molecular clock modeling to determine the divergence date of measles virus and rinderpest virus. Read More

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http://dx.doi.org/10.1126/science.aba9411DOI Listing

Dating the emergence of human pathogens.

Science 2020 06;368(6497):1310-1311

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1126/science.abc5746DOI Listing
June 2020
31.477 Impact Factor

Transmission dynamics of and insights from the 2018-2019 measles outbreak in New York City: A modeling study.

Authors:
Wan Yang

Sci Adv 2020 May 27;6(22):eaaz4037. Epub 2020 May 27.

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.

In 2018-2019, New York City experienced the largest measles outbreak in the United States in nearly three decades. To identify key contributing factors, we modeled the transmission dynamics of this outbreak. Results indicate that delayed vaccination of 1- to 4-year-olds enabled the initial spread and that increased infectious contact, likely via "measles parties," facilitated later transmission. Read More

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http://dx.doi.org/10.1126/sciadv.aaz4037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272232PMC

Routine vaccination during covid-19 pandemic response.

BMJ 2020 06 16;369:m2392. Epub 2020 Jun 16.

UCL Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1136/bmj.m2392DOI Listing

Explaining socioeconomic inequalities in immunisation coverage in India: new insights from the fourth National Family Health Survey (2015-16).

BMC Pediatr 2020 Jun 16;20(1):295. Epub 2020 Jun 16.

International Institute for Population Sciences, Mumbai, 400088, India.

Background: Childhood vaccinations are a vital preventive measure to reduce disease incidence and deaths among children. As a result, immunisation coverage against measles was a key indicator for monitoring the fourth Millennium Development Goal (MDG), aimed at reducing child mortality. India was among the list of countries that missed the target of this MDG. Read More

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http://dx.doi.org/10.1186/s12887-020-02196-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296926PMC
June 2020
1.918 Impact Factor

A Serosurvey Identifying Vulnerability to Measles in Health Care Workers. A Hospital-Based Prospective Seroprevalence Study.

Int J Environ Res Public Health 2020 Jun 12;17(12). Epub 2020 Jun 12.

Third Faculty of Medicine, Charles University in Prague, 10000 Prague, Czech Republic.

The aim of this serological survey was to assess the persistence of measles antibodies among health care workers (HCWs) at risk of incidental measles. A prospective study of measles-specific antibodies in serum samples obtained from a total of 2782 participants aged 19-89 years was conducted between May 2018 and December 2019. The seropositivity rate of 93. Read More

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http://dx.doi.org/10.3390/ijerph17124219DOI Listing

Mapping a nosocomial outbreak of measles, coinciding with a period of sustained transmission in South London in 2018.

J Hosp Infect 2020 Jun 13. Epub 2020 Jun 13.

Department of Infection, Guy's and St Thomas' NHS Foundation Trust, London, UK.

A measles outbreak in London is described, involving 34 cases across two hospitals and a local community across two countries. After a single introduction to hospital, spread propagated via unvaccinated retail shop workers to healthcare staff, highlighting the importance of expanding occupational health policies to non-clinical hospital staff. Further spread into an under-vaccinated Traveller community is a reminder that measles can spread in the absence of herd immunity. Read More

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http://dx.doi.org/10.1016/j.jhin.2020.06.004DOI Listing