31,002 results match your criteria Measles Rubeola

Effectiveness of immunization activities on measles and rubella immunity among individuals in East Sepik, Papua New Guinea: A cross-sectional study.

IJID Reg 2022 Jun 3;3:84-88. Epub 2022 Mar 3.

Bureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, Japan.

Objectives: This study aimed to assess measles and rubella immunity by measuring virus-specific immunoglobulin G (IgG) prevalence among individuals and evaluate the effectiveness of recent supplementary immunization activities (SIAs) by comparing the antibody positivity rates of the SIA target age groups in 2015 with those in 2019 as measles and rubella are endemic in Papua New Guinea.

Methods: A cross-sectional study. The measles- and rubella-specific IgG levels of patients aged ≥1 year at two clinics in East Sepik province, Papua New Guinea were assessed with commercially available virus-specific IgG EIA kits. Read More

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Beware of α-lactalbumin as a hidden allergen in measles, mumps, and rubella vaccine in the patients with cow's milk allergy.

Pediatr Allergy Immunol 2022 06;33(6)

Division of Pediatrics, Department of Pediatric Allergy and Immunology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

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Immunogenicity and safety of the inactivated enterovirus 71 vaccine administered concomitantly with the measles-rubella vaccine in infants aged 8 months in China: A noninferiority randomized controlled trial.

Vaccine 2022 Jun 23. Epub 2022 Jun 23.

Guangdong Provincial Institute of Biological Products and Materia Medica, Guangzhou, Guangdong 510440, China; NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, Guangzhou, Guangdong 510315, China. Electronic address:

Background: To evaluate the immunogenicity and safety of simultaneous administration of the enterovirus 71 (EV71) vaccine with the measles and rubella (MR) combined vaccine.

Methods: In this phase 4, randomized, open-label and noninferiority study, a total of 680 infants aged 8 months were enrolled and assigned to the simultaneous administration group (infants received the first dose of EV71 vaccine and MR vaccine on Day 0, and the second dose of EV71 vaccine on Day 28), or the separate administration groups (EV71 group: infants received two doses of EV71 vaccine on Day 0 and Day 28, respectively; MR group: infants received MR vaccine on Day 0). Blood sample was obtained on Day 0 and Day 56 to measure antibody responses to each of the antigens in terms of antibody titer or concentration, respectively. Read More

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Effect of early two-dose measles vaccination on childhood mortality and modification by maternal measles antibody in Guinea-Bissau, West Africa: A single-centre open-label randomised controlled trial.

EClinicalMedicine 2022 Jul 27;49:101467. Epub 2022 May 27.

Bandim Health Project, Indepth Network, Apartado 861, Bissau, Guinea-Bissau.

Background: Early 2-dose measles vaccine (MV) at 4 and 9 months of age vs. the WHO strategy of MV at 9 months of age reduced all-cause child mortality in a previous trial. We aimed to test two hypotheses: 1) a 2-dose strategy reduces child mortality between 4 and 60 months of age by 30%; 2) receiving early MV at 4 months in the presence versus absence of maternal measles antibodies (MatAb) reduces child mortality by 35%. Read More

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Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds.

Viruses 2022 May 29;14(6). Epub 2022 May 29.

Department of Viroscience, Erasmus MC, 3015 GD Rotterdam, The Netherlands.

Measles virus (MV) is a highly contagious respiratory virus responsible for outbreaks associated with significant morbidity and mortality among children and young adults. Although safe and effective measles vaccines are available, the COVID-19 pandemic has resulted in vaccination coverage gaps that may lead to the resurgence of measles when restrictions are lifted. This puts individuals who cannot be vaccinated, such as young infants and immunocompromised individuals, at risk. Read More

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Immunogenicity and Safety of an Inactivated Enterovirus 71 Vaccine Administered Simultaneously with Hepatitis B Virus Vaccine, Group A Meningococcal Polysaccharide Vaccine, Measles-Rubella Combined Vaccine and Japanese Encephalitis Vaccine: A Multi-Center, Randomized, Controlled Clinical Trial in China.

Vaccines (Basel) 2022 Jun 2;10(6). Epub 2022 Jun 2.

Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.

Background: The aim of this study was to investigate the immunogenicity and safety of the enterovirus 71 vaccine (EV71 vaccine) administered alone or simultaneously.

Methods: A multi-center, open-label, randomized controlled trial was performed involving 1080 healthy infants aged 6 months or 8 months from Shandong, Shanxi, Shaanxi, and Hunan provinces. These infants were divided into four simultaneous administration groups and EV71 vaccine separate administration group. Read More

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A Mouse-Based Method to Monitor Wheat Allergens in Novel Wheat Lines and Varieties Created by Crossbreeding: Proof-of-Concept Using Durum and Wheats.

Int J Mol Sci 2022 Jun 10;23(12). Epub 2022 Jun 10.

Food Allergy & Immunology Laboratory, Department of Food Science & Human Nutrition, Michigan State University, East Lansing, MI 48824, USA.

Wheat allergies are potentially life-threatening because of the high risk of anaphylaxis. Wheats belong to four genotypes represented in thousands of lines and varieties. Monitoring changes to wheat allergens is critical to prevent inadvertent ntroduction of hyper-allergenic varieties via breeding. Read More

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Cascading Risks for Preventable Infectious Diseases in Children and Adolescents during the 2022 Invasion of Ukraine.

Int J Environ Res Public Health 2022 Jun 8;19(12). Epub 2022 Jun 8.

Center for Disaster & Extreme Event Preparedness (DEEP Center), P3H: Protect & Promote Population Health in Complex Crises, Department of Public Health Sciences, University of Miami Miller School of Medicine, Don Soffer Clinical Research Center Room 1507, 1120 NW 14 St., Miami, FL 33136, USA.

Russia's military incursion into Ukraine triggered the mass displacement of two-thirds of Ukrainian children and adolescents, creating a cascade of population health consequences and producing extraordinary challenges for monitoring and controlling preventable pediatric infectious diseases. From the onset of the war, infectious disease surveillance and healthcare systems were severely disrupted. Prior to the reestablishment of dependable infectious disease surveillance systems, and during the early months of the conflict, our international team of pediatricians, infectious disease specialists, and population health scientists assessed the health implications for child and adolescent populations. Read More

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NK Cell Effector Functions and Bystander Tumor Cell Killing in Immunovirotherapy.

Methods Mol Biol 2022 ;2521:233-248

Center for Biomedical Research and Education (ZBAF), School of Medicine, Institute of Virology and Microbiology, Faculty of Health, Witten/Herdecke University, Witten, Germany.

Oncolytic virotherapy is a compelling strategy to combine cancer gene therapy with immunotherapy. Lytic virus replication in malignant cells not only enables localized transgene expression based on engineered vectors but also triggers immunogenic tumor cell death and elicits inflammation in the tumor microenvironment. Modified oncolytic viruses encoding immunomodulators have been developed to enhance antitumor immune effects and therapeutic efficacy. Read More

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Evaluation of the detection of specific IgM against measles virus by the chemiluminescence immunoassay Liaison® Measles IgM.

Enferm Infecc Microbiol Clin (Engl Ed) 2022 Jun 18. Epub 2022 Jun 18.

Consorcio de Investigación Biomédica de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Laboratorio de Referencia e Investigación en Enfermedades Víricas Inmunoprevenibles, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.

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Estimating the number of US children susceptible to measles resulting from COVID-19-related vaccination coverage declines.

Vaccine 2022 Jun 15. Epub 2022 Jun 15.

Emory University, Rollins School of Public Health, Dept. of Epidemiology, Atlanta, GA 30322, USA; Emory University, Rollins School of Public Health, Hubert Dept. of Global Health, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA. Electronic address:

Measles elimination hinges on vaccination coverage remaining above 95% to retain sufficient community protection. Recent declines in routine measles vaccinations due to the COVID-19 pandemic coupled with prior models indicating the country was close to the 92% herd immunity benchmark are a cause for concern. We evaluated population-level measles susceptibility in the US, including sensitivity analyses accounting for pandemic-related impacts on immunization. Read More

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Impact of vaccine effectiveness and coverage on preventing large mumps outbreaks on college campuses: Implications for vaccination strategy.

Epidemics 2022 Jun 17;40:100594. Epub 2022 Jun 17.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

Recent mumps outbreaks among highly vaccinated populations, including college students, have called into question the vaccine effectiveness (VE) of routine two-dose measles, mumps, and rubella (MMR2) immunization. We aimed to estimate the VE required for a novel vaccination strategy (e.g. Read More

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Early childhood education staff are falling through a vaccination policy gap in New Zealand.

N Z Med J 2022 Jan 21;135(1548):96-102. Epub 2022 Jan 21.

Office of Early Childhood Education.

The recent COVID-19 vaccine mandate among early childhood education (ECE) staff highlights the important role ECE staff have in the transmission of infectious diseases. However, there are no data on general vaccine uptake for this group in New Zealand. Additionally, the importance of ECE staff vaccination as a strategy to prevent illness has been rarely promoted in the past, and recommendations for other vaccinations in this group are lacking. Read More

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January 2022

Comparison of a chemiluminescence immunoassay and an enzyme immunoassay for detection of IgM antibodies against measles, mumps, rubella, cytomegalovirus (CMV), Epstein Barr virus (EBV), and human herpes virus (HHV) -1 and -2 infections.

Indian J Med Microbiol 2022 Jun 17. Epub 2022 Jun 17.

Department of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, India. Electronic address:

Purpose: Outbreaks of vaccine-preventable viral diseases have been increasingly reported globally over the past few years. The burden of congenital viral infections, their impact on physical and mental development and the resulting economic loss to the family and the community are also well known. IgM antibody detection has been convenient in the diagnosis of acute viral infections, particularly in settings with limited resources where molecular tests are not feasible. Read More

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EULAR/PRES recommendations for vaccination of paediatric patients with autoimmune inflammatory rheumatic diseases: update 2021.

Ann Rheum Dis 2022 Jun 20. Epub 2022 Jun 20.

RITA, European Reference Networks, Brussels, Belgium.

Objectives: Recent insights supporting the safety of live-attenuated vaccines and novel studies on the immunogenicity of vaccinations in the era of biological disease-modifying antirheumatic drugs in paediatric patients with autoimmune/inflammatory rheumatic diseases (pedAIIRD) necessitated updating the EULAR recommendations.

Methods: Recommendations were developed using the EULAR standard operating procedures. Two international expert committees were formed to update the vaccination recommendations for both paediatric and adult patients with AIIRD. Read More

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Adverse Event Following Immunization (AEFI) in Children: An Analysis of Reporting in VigiAccess.

Drug Res (Stuttg) 2022 Jun 20. Epub 2022 Jun 20.

Department of Pharmacology, Raj Kumar Goel Institute of Technology (Pharmacy), Ghaziabad, Uttar Pradesh, India.

Introduction: It is an indubitable fact that vaccination has been instrumental in the eradication and prevention of the deadliest diseases worldwide. Continuous vaccine safety surveillance is helpful to counter the negative perception and thus allay the fear of Adverse Events Following Immunization (AEFI) in the general public. VigiAccess, the WHO global database of reported side effects of medicinal products, can be accessed by the public at large. Read More

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The indirect impact of control measures in COVID-19 pandemic on the incidence of other infectious diseases in China.

Public Health Pract (Oxf) 2022 Dec 13;4:100278. Epub 2022 Jun 13.

Infectious Diseases Department, Jinan Children's Hospital: Children's Hospital Affiliated to Shandong University, No. 23976 Jingshi Road, Jinan, 250022, Jinan, China.

Objectives: During COVID-19 pandemic in 2020, China, some public health measures of forced lockdown, closure of school and public meeting places, staying at home, transportation stop, masks wearing, hands washing, environmental disinfection were taken on to control epidemic transmission, these measures have made indirect affect on the other infectious diseases incidence.

Study Design: During COVID-19 pandemic in 2020, we retrospectively analyzed and compared reported cases of other infectious diseases,in order to found what impact of measures in controlling COVID-19 pandemic on the other infectious diseases in China.

Methods: We retrospectively analyzed and compared reported cases of measles, pertussis, scarlet fever, seasonal influenza, mumps, HFMD each month in 2018, 2019 and 2020 from the National Health Commission, PRC. Read More

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December 2022

Epstein-Barr Virus-Encoded BILF1 Orthologues From Porcine Lymphotropic Herpesviruses Display Common Molecular Functionality.

Front Endocrinol (Lausanne) 2022 26;13:862940. Epub 2022 May 26.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Infection of immunosuppressed transplant patients with the human γ-herpesvirus Epstein-Barr virus (EBV) is associated with post-transplant lymphoproliferative disease (PTLD), an often fatal complication. Immunosuppressed miniature pigs infected with γ-herpesvirus porcine lymphotropic herpesvirus 1 (PLHV1) develop a similar disease, identifying pigs as a potential preclinical model for PTLD in humans. BILF1 is a G protein-coupled receptor (GPCR) encoded by EBV with constitutive activity linked to tumorigenesis and immunoevasive function downregulating MHC-I. Read More

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Vaccination policies for healthcare personnel: Current challenges and future perspectives.

Vaccine X 2022 Aug 31;11:100172. Epub 2022 May 31.

Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Healthcare personnel (HCP) are at occupational risk for acquisition of several vaccine-preventable diseases and transmission to patients. Vaccinations of HCP are justified to confer them immunity but also to protect susceptible patients and healthcare services from outbreaks, HCP absenteeism and presenteeism. Mandatory vaccination policies for HCP are increasingly adopted and achieve high and sustainable vaccination rates in short term. Read More

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Current status of human adenovirus infection in China.

World J Pediatr 2022 Jun 18. Epub 2022 Jun 18.

NHC Key Laboratory of Medical Virology and Viral Diseases, WHO WPRO Regional Reference Laboratory of Measles and Rubella, Chinese Center for Disease Control and Prevention, Measles Laboratory in National Institute for Viral Disease Control and Prevention, 155# Changbai Road, Changping District, Beijing, 102206, China.

Background: Outbreaks of severe, acute hepatitis among children have recently attracted global attention. The pathogen causing the outbreak remains unknown, but there is growing evidence that it may be associated with human adenovirus (HAdV).

Data Sources: A review of adenovirus-related clinical studies, epidemiological studies, etiological studies, and case reports was conducted by reviewers independently. Read More

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Leveraging a national biorepository in Zambia to assess measles and rubella immunity gaps across age and space.

Sci Rep 2022 Jun 17;12(1):10217. Epub 2022 Jun 17.

International Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 415 N Washington Street, 5th floor, Baltimore, MD, 21231, USA.

High-quality, representative serological surveys allow direct estimates of immunity profiles to inform vaccination strategies but can be costly and logistically challenging. Leveraging residual serum samples is one way to increase their feasibility. We subsampled 9854 residual sera from a 2016 national HIV survey in Zambia and tested these specimens for anti-measles and anti-rubella virus IgG antibodies using indirect enzyme immunoassays. Read More

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Evaluation of vaccination status of health care workers for recommended vaccines and their acceptance of SARS-CoV-2 vaccines.

Hum Vaccin Immunother 2022 Jun 17:1-6. Epub 2022 Jun 17.

Introduction: Health care workers (HCWs) are disproportionately exposed to infectious diseases and play a role in nosocomial transmission, making them a key demographic for vaccination. HCW vaccination rates are not optimal in many countries; hence, compulsory vaccination policies have been implemented in some countries. Although these policies are effective and necessary under certain conditions, resolving HCWs' hesitancies and misconceptions about vaccines is crucial. Read More

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Trends and outcomes of admissions in the Paediatrics ward at a tertiary care hospital of urban Karachi.

J Pak Med Assoc 2022 May;72(5):954-957

Department of Paediatrics, Bahria University Medical and Dental College, Karachi, Pakistan.

In order to improve the health care system in Pakistan, the first step is to assess which diseases are the most prevalent and to what extent among children and lead to hospital admissions. This would help to improve the facilities and management and thus reduce the duration of hospital stay. This study aimed to determine the spectrum of disease presentation and the outcome and duration of hospital stay of patients presenting to the paediatric ward of a tertiary care hospital. Read More

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Measles Epidemiology and Viral Nucleoprotein Gene Evolution in Shandong Province, China.

J Med Virol 2022 Jun 16. Epub 2022 Jun 16.

School of Life Sciences, Shandong First Medical University, Tai'an, Shandong, 271000, China.

Measles, caused by measles virus (MeV), has not been eradicated in many regions and countries, threatening human health. Thus, it is beneficial for measles elimination to understand measles epidemiology and molecular evolution of key viral genes, such as nucleoprotein (N) gene. Based on public data, measles epidemiological information and MeV N gene sequences reported in Shandong Province, China were comprehensively collected and systematically analyzed. Read More

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Individual-level social capital and COVID-19 vaccine hesitancy in Japan: a cross-sectional study.

Hum Vaccin Immunother 2022 Jun 16:1-7. Epub 2022 Jun 16.

Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan.

To reduce vaccine hesitancy, it is important to identify factors that can intervene at the individual or community level. Social capital is a possible factor because it is associated with various vaccine hesitancy, such as for measles and influenza. However, limited studies have explored the association between social capital and vaccination for COVID-19, which is an unprecedented pandemic and infodemic. Read More

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Measles Elimination Successful and Its Relevant Challenges in Iran.

Int J Prev Med 2022 5;13:52. Epub 2022 Apr 5.

National Medical Emergency Organization, Ministry of Health & Medical Education, Tehran, Iran.

Measles is an infectious childhood disease with some death annually. The expansion of the coverage of vaccination plan has significantly reduced the mortality rate of this disease. Given that the endemic measles virus is not transmitted in the country and based on Regional Verification Commission (RVC) for Measles and Rubella Elimination has declared that measles and rubella have been eliminated in three countries of Eastern Mediterranean Region including Islamic Republic of Iran, Bahrain, and Oman. Read More

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A Case of Painless Subacute Thyroiditis Presenting as Fever of Unknown Origin.

Cureus 2022 May 12;14(5):e24949. Epub 2022 May 12.

Internal Medicine, Rochester Regional Health, Rochester, USA.

Subacute thyroiditis (SAT) is characterized by severe pain in the anterior aspect of the neck and tenderness is present during the thyroid gland's palpation. It is commonly caused by viruses including mumps, measles, rubella, coxsackievirus, influenza, and Epstein-Barr virus (EBV). Painless subacute thyroiditis is rare and can present as a fever of unknown origin (FUO). Read More

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Measles resurgence in Brazil: analysis of the 2019 epidemic in the state of São Paulo.

Rev Saude Publica 2022 13;56:50. Epub 2022 Jun 13.

Universidade Federal do Rio de Janeiro. Instituto de Estudos em Saúde Coletiva. Rio de Janeiro, RJ, Brasil.

Objective: To analyze the epidemiological profile of cases and the pattern of spatial diffusion of the largest measles epidemic in Brazil that occurred in the post-elimination period in the state of São Paulo.

Method: A cross-sectional study based on confirmed measles cases in 2019. Bivariate analysis was performed for socioeconomic, clinical, and epidemiological variables, according to prior vaccination and hospitalization, combined with an analysis of spatial diffusion of cases using the Inverse Distance Weighting (IDW) method. Read More

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Vaccination games in prevention of infectious diseases with application to COVID-19.

Chaos Solitons Fractals 2022 Aug 10;161:112294. Epub 2022 Jun 10.

School of Mathematics and Statistics, Southwest University, Chongqing 400715, China.

Vaccination coverage is crucial for disease prevention and control. An appropriate combination of compulsory vaccination with voluntary vaccination is necessary to achieve the goal of herd immunity for some epidemic diseases such as measles and COVID-19. A mathematical model is proposed that incorporates both compulsory vaccination and voluntary vaccination, where a decision of voluntary vaccination is made on the basis of game evaluation by comparing the expected returns of different strategies. Read More

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The Italian Mandatory Notification System: An Important Public Health Tool For Continuous Monitoring Of Infectious Diseases.

New Microbiol 2022 04;45(2):115-123

Multi-Specialist Clinical Institute for Orthopaedic Trauma Care (COT), Messina, Italy

Infectious diseases still register significant morbidity and mortality worldwide. Surveillance through a mandatory notification system allows the continuous analysis of the situation even at a local level and its importance has been highlighted by the recent COVID-19 pandemic. This paper aimed to outline the importance of the mandatory notification system as a Public Health tool in the continuous monitoring of infectious diseases. Read More

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