Search our Database of Scientific Publications and Authors

I’m looking for a

    26570 results match your criteria Measles Rubeola

    1 OF 532

    Update From the Advisory Committee on Immunization Practices.
    J Pediatric Infect Dis Soc 2017 Sep 25. Epub 2017 Sep 25.
    Department of Pediatrics, University of Alabama at Birmingham.
    The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Read More

    Knowledge and attitude of mothers regarding infant hearing loss in Changsha, Hunan province, China.
    Int J Audiol 2017 Oct 16:1-6. Epub 2017 Oct 16.
    a Department of Pediatric Ophthalmology and Otorhinolaryngology , Hunan Provincial Maternal and Child Health Care Hospital , Changsha , Hunan Province , China.
    Objective: The objective of this study was to explore the knowledge and attitude among mothers of newborns regarding infant hearing loss (HL) in Changsha, Hunan province, China.

    Design: A questionnaire including 18 items was given to mothers.

    Study Sample: A total of 115 mothers participated in the study. Read More

    'Hesitant compliers': Qualitative analysis of concerned fully-vaccinating parents.
    Vaccine 2017 Oct 11. Epub 2017 Oct 11.
    School of Population and Global Health, The University of Western Australia, Australia; Telethon Kids Institute, The University of Western Australia, Australia.
    Objective: Some parents are hesitant about vaccines and yet still vaccinate their children. Vaccine behaviours are not fixed and parents who are concerned but nonetheless adherent to standard schedules could switch to an unconventional schedule, delaying or cherry-picking vaccines. There is a need to better understand vaccine hesitancy in specific contexts, acknowledging cultural and geographical variation, to ensure interventions targeting hesitancy are well directed and received. Read More

    Timeliness of childhood vaccination in the Federated States of Micronesia.
    Vaccine 2017 Oct 10. Epub 2017 Oct 10.
    Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Immunization Services Division, Atlanta, GA, United States.
    Background: Vaccination coverage is typically measured as the proportion of individuals who have received recommended vaccine doses by the date of assessment. This approach does not provide information about receipt of vaccines by the recommended age, which is critical for ensuring optimal protection from vaccine-preventable diseases (VPDs).

    Objective: To assess vaccination timeliness in the Federated States of Micronesia (FSM), and the projected impact of suboptimal vaccination in the event of an outbreak. Read More

    Effectiveness of Measles Vaccination and Immune Globulin Post-Exposure Prophylaxis in an Outbreak Setting-New York City, 2013.
    Clin Infect Dis 2017 Sep 23. Epub 2017 Sep 23.
    New York City Department of Health and Mental Hygiene, New York.
    Background: Measles, mumps, and rubella vaccine (MMR) or immune globulin (IG) are routinely used for measles post-exposure prophylaxis (PEP). However, current literature on the effectiveness of measles PEP is limited and variable. Here, we examined the effectiveness of MMR and IG PEP among children exposed to measles during an outbreak in New York City (NYC) in 2013. Read More

    P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission.
    PLoS One 2017 13;12(10):e0186577. Epub 2017 Oct 13.
    Burnet Institute, Melbourne, Victoria, Australia.
    Introduction: During pregnancy, immunoglobulin G (IgG) is transferred from the mother to the fetus, providing protection from disease in early infancy. Plasmodium falciparum infections may reduce maternofetal antibody transfer efficiency, but mechanisms remain unclear.

    Methods: Mother-cord paired serum samples collected at delivery from Papua New Guinea (PNG) and the Thailand-Myanmar Border Area (TMBA) were tested for IgG1 and IgG3 to four P. Read More

    Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.
    Cell Host Microbe 2017 Oct;22(4):460-470.e5
    Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA. Electronic address:
    Respiratory and arthropod-borne viral infections are a global threat due to the lack of effective antivirals and vaccines. A potential strategy is to target host proteins required for viruses but non-essential for the host. To identify such proteins, we performed a genome-wide knockout screen in human haploid cells and identified the calcium pump SPCA1. Read More

    Vaccination Coverage for Selected Vaccines, Exemption Rates, and Provisional Enrollment Among Children in Kindergarten - United States, 2016-17 School Year.
    MMWR Morb Mortal Wkly Rep 2017 Oct 13;66(40):1073-1080. Epub 2017 Oct 13.
    State and local school vaccination requirements help protect students and communities against vaccine-preventable diseases (1). CDC reports vaccination coverage and exemption data for children attending kindergarten (kindergartners) collected by federally funded immunization programs in the United States.* The typical age range for kindergartners is 4-6 years. Read More

    Mumps outbreak in a highly vaccinated university-affiliated setting before and after a measles-mumps-rubella (MMR) vaccination campaign-Iowa, July 2015-May 2016.
    Clin Infect Dis 2017 Aug 16. Epub 2017 Aug 16.
    Centers for Disease Control and Prevention, Atlanta, GA.
    Background: In response to a mumps outbreak at the University of Iowa and surrounding community, university, state, and local health officials implemented a vaccination campaign targeting students <25 years of age with an additional dose of measles-mumps-rubella (MMR) vaccine. Over 4,700 vaccine campaign doses were administered; 97% were documented third doses. We describe the epidemiology of the outbreak before and after the campaign, focusing on cases in university students. Read More

    Prevalence of risk factors for acquiring measles during the 2011 outbreak in Quebec and impact of the province-wide school-based vaccination campaign on population immunity.
    PLoS One 2017 11;12(10):e0186070. Epub 2017 Oct 11.
    British Columbia Center for Disease Control, Vancouver, BC, Canada.
    Background: A large measles outbreak occurred in Quebec, Canada, in 2011. Although nearly two-thirds of the cases occurred in only two health districts, a mass vaccination campaign targeting all Quebec elementary and high school students without valid two-dose history was undertaken to prevent future outbreaks. We compared rates of non-vaccination and age at first measles vaccine dose among students in the two most-affected districts and the rest of the province and estimated the improvement in overall student measles immunity due to the mass school-based vaccination campaign. Read More

    Randomized Trial of 2 Versus 1 Dose of Measles Vaccine: Effect on Hospital Admission of Children After 9 Months of Age.
    J Pediatric Infect Dis Soc 2017 Jun 15. Epub 2017 Jun 15.
    Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau.
    Background: Two doses of measles vaccine (MV) might reduce the nonmeasles mortality rate more than 1 dose of MV does. The effect of 2 versus 1 dose on morbidity has not been examined. Within a randomized trial of the effect of 2 doses versus 1 dose of MV on mortality in Guinea-Bissau, we investigated the effect on hospital admissions. Read More

    Integrating primary eye care into global child health policies.
    Arch Dis Child 2017 Oct 7. Epub 2017 Oct 7.
    Department of Clinical Research, International Centre of Eye Health, London School of Hygiene and Tropical Medicine, London, UK.
    Globally, approximately 75% of blind children live in low-income countries (LICs). Almost half of blindness and low vision in LICs is due to avoidable causes such as corneal scarring from measles infection, vitamin A deficiency disorders, use of harmful traditional eye remedies, ophthalmia neonatorum and cataract. Read More

    Emergent Lineages of Mumps Virus Suggest the Need for a Polyvalent Vaccine.
    Int J Infect Dis 2017 Oct 4. Epub 2017 Oct 4.
    University of New England, Biddeford, Maine USA.
    Mumps outbreaks among vaccinated patients have become increasingly common in recent years. While there are multiple conditions driving this re-emergence, convention has suggested that these outbreaks are associated with waning immunity rather than vaccine escape. Molecular evidence from both the ongoing American and Dutch outbreaks in conjunction with recent structural biology studies challenge this convention, and suggest that emergent lineages of mumps virus exhibit key differences in antigenic epitopes from the employed vaccine strain Jeryl-Lynn 5. Read More

    Measles outbreak investigation in Guji zone of Oromia Region, Ethiopia.
    Pan Afr Med J 2017 9;27(Suppl 2). Epub 2017 Jun 9.
    World Health Organization Country Office, Addis Abba, Ethiopia.
    Introduction: Despite the increase of immunization coverage (administrative) of measles in the country, there are widespread outbreaks of measles. In this respect, we investigated one of the outbreaks that occurred in hard to reach kebeles of Guji Zone, Oromia region, to identify the contributing factors that lead to the protracted outbreak of measles.

    Methods: We used a cross-sectional study design to investigate a measles outbreak in Guji zone, Oromia region. Read More

    Status of surveillance and routine immunization performances in Amhara Region, Ethiopia: findings from in-depth peer review.
    Pan Afr Med J 2017 9;27(Suppl 2). Epub 2017 Jun 9.
    World Health Organization, Ethiopia.
    Introduction: Trend analyses of non-polio AFP and stool adequacy rates in Amhara Region showed optimal performance over the years. However, sub regional gaps continue to persist in certain zones where the reasons for low performance were not well documented. The objective of this study was to assess the performance of the disease surveillance and immunization system in Amhara Region, Ethiopia with emphasis on low performing woredas and zones. Read More

    Effects of polio eradication activities on routine immunization: lessons from the 2013 outbreak response in Somali region of Ethiopia.
    Pan Afr Med J 2017 9;27(Suppl 2). Epub 2017 Jun 9.
    World Health Organization, Ethiopia.
    Introduction: Ethiopia experienced several WPV importations with a total of 10 WPV1 cases confirmed during the 2013 outbreak alone before it is closed in 2015. We evaluated supplemental immunization activities (SIAs), including lessons learned for their effect on the routine immunization program during the 2013 polio outbreak in Somali regional state.

    Methods: We used descriptive study to review documents and analyse routine health information system reports from the polio outbreak affected Somali regional state. Read More

    Behavioral determinants of immunization service utilization in Ethiopia: a cross-sectional community-based survey.
    Pan Afr Med J 2017 9;27(Suppl 2). Epub 2017 Jun 9.
    Jimma University, Ethiopia.
    Introduction: According to the Ethiopian Health Sector Development Plan IV annual performance report (HSDP IV), Ethiopia targeted to reach 90% coverage with DPT-Hib-HepB 3 (Pentavalent3) vaccine and 86% coverage with measles vaccine in 2010- 2011. However, the actual performance fell-short of the intended targets due to several reasons. Therefore, a nationwide comprehensive study was conducted to examine the behavioral determinants of immunization practices in the Ethiopian context. Read More

    A pilot study of routine immunization data quality in Bunza Local Government area: causes and possible remedies.
    Pan Afr Med J 2017 2;27:239. Epub 2017 Aug 2.
    World Health Organisation, Office of Country Representative, Abuja, Nigeria.
    Introduction: As a result of poor quality administrative data for routine immunisation (RI) in Nigeria, the real coverage of RI remains unknown, constituting a setback in curtailing vaccine preventable diseases (VPDs). Consequently, the purpose of this pilot study is to identify source(s) and evaluate the magnitude of poor data quality as well as propose recommendations to address the problem.

    Methods: The authors conducted a cross-sectional study in which 5 out of the 22 health facilities providing routine immunization services in Bunza Local Government Area (LGA), Kebbi State, Nigeria, were selected for data quality assessment. Read More

    Genome-scale detection of positive selection in nine primates predicts human-virus evolutionary conflicts.
    Nucleic Acids Res 2017 Aug 11. Epub 2017 Aug 11.
    Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
    Hotspots of rapid genome evolution hold clues about human adaptation. We present a comparative analysis of nine whole-genome sequenced primates to identify high-confidence targets of positive selection. We find strong statistical evidence for positive selection in 331 protein-coding genes (3%), pinpointing 934 adaptively evolving codons (0. Read More

    Transcription analysis of the responses of porcine heart to Erysipelothrix rhusiopathiae.
    PLoS One 2017 4;12(10):e0185548. Epub 2017 Oct 4.
    Unit of Animal Infectious Diseases, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, P.R. China.
    Erysipelothrix rhusiopathiae (E. rhusiopathiae) is the causative agent of swine erysipelas. This microbe has caused great economic losses in China and in other countries. Read More

    Screening of peste des petits ruminants virus in a population of district Khairpur, Pakistan.
    Genet Mol Res 2017 Sep 28;16(3). Epub 2017 Sep 28.
    Pest and Disease Research Laboratory, Department of Agriculture and Agribusiness, , , Pakistan
    Goats are the Pakistan's fastest growing ruminants, and Pakistan is the third largest goat producer in the world after India and China. Goat meat preference is the main reason for its increased demand. In the country, there are 25 goat breeds and two wild relatives such as Mark and Goats. Read More

    Absence of Measles Virus Detection from Stapes of Patients with Otosclerosis.
    Otolaryngol Head Neck Surg 2017 Sep 1:194599817733674. Epub 2017 Sep 1.
    2 Infectious Disease Division, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.
    Objective To determine molecularly the presence of measles virus genetic material in the stapes of patients with otosclerosis. Study Design A cross-sectional study. Setting A tertiary referral hospital. Read More

    Measles Outbreak in the Adolescent Population - Matter of Concern?
    J Clin Diagn Res 2017 Aug 1;11(8):LC20-LC23. Epub 2017 Aug 1.
    Professor, Department of Community Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
    Introduction: Measles is a disease predominantly seen in young children and infants. It is an unusual occurrence of the disease in the adolescent population warranting an investigation. This would help understand the possible cause-effect relation, changing epidemiology of the disease and immunity gaps to initiate targeted interventional strategies. Read More

    Cap-dependent translational control of oncolytic measles virus infection in malignant mesothelioma.
    Oncotarget 2017 Sep 27;8(38):63096-63109. Epub 2017 Jun 27.
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
    Malignant mesothelioma has a poor prognosis for which there remains an urgent need for successful treatment approaches. Infection with the Edmonston vaccine strain (MV-Edm) derivative of measles virus results in lysis of cancer cells and has been tested in clinical trials for numerous tumor types including mesothelioma. Many factors play a role in MV-Edm tumor cell selectivity and cytopathic activity while also sparing non-cancerous cells. Read More

    Measles Antibodies in Mother-Infant Dyads in Tianjin, China.
    J Infect Dis 2017 Sep 2. Epub 2017 Sep 2.
    Division of Expanded Programs on Immunization, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
    Background: Many measles cases in Tianjin, China, occur in infants whose mothers were born after widespread vaccination programs. We assessed age-specific decreases in maternal measles antibodies in infants and examined maternal and infant characteristics in relation to infant antibody titers.

    Methods: Infant and mother dyads were enrolled from a sample of immunization clinics in all Tianjin districts. Read More

    Measles Virus Neutralizing Antibodies in Intravenous Immunoglobulins:is an Increase by Re-Vaccination of Plasma Donors possible?
    J Infect Dis 2017 Aug 18. Epub 2017 Aug 18.
    Global Pathogen Safety, Shire, 1221 Vienna, Austria.
    We report a screen of plasma donors which confirmed that widespread use of childhood measles vaccination since 1963 resulted in a decrease of average measles virus antibody titers in plasma donors, which is reflected in intravenous immunoglobulins (IVIG). The measles virus antibody titer is, however, a potency requirement for IVIG, as defined in FDA regulation. To mitigate the decline in measles virus antibody titers in IVIG and to ensure consistent product release, re-vaccination of plasma donors was investigated as a means to boost titers. Read More

    Successful African introduction of a new Group A meningococcal conjugate vaccine: Future challenges and next steps.
    Hum Vaccin Immunother 2017 Oct 2. Epub 2017 Oct 2.
    d WHO , Geneva .
    The introduction of a new Group A meningococcal conjugate vaccine, MenAfriVac(R), has been a important public health success. Group A meningococcal meningitis has disappeared in all countries where the new Men A conjugate vaccine has been used at public health scale. However, continued control of Group A disease in sub-Saharan Africa will require that community immunity against Group A meningococci be maintained. Read More

    Canonical modeling of anticipatory vaccination behavior and long term epidemic recurrence.
    J Theor Biol 2017 Sep 28;436:26-38. Epub 2017 Sep 28.
    University of Lyon, École centrale de Lyon France; CNRS UMR 5208, Institut Camille Jordan, 36 avenue Guy de Collongue, F-69134 Ecully Cedex, France. Electronic address:
    Vaccination is one of humanity's main tools to fight epidemics. In most countries and for most diseases, vaccination is offered on a voluntary basis. Hence, the spread of a disease can be described as two interacting opposite dynamic systems: contagion is determined by past vaccination, while individuals decide whether to vaccinate based on beliefs regarding future disease prevalence. Read More

    Assessing the cost-effectiveness of different measles vaccination strategies for children in the Democratic Republic of Congo.
    Vaccine 2017 Oct 28;35(45):6187-6194. Epub 2017 Sep 28.
    Department of Epidemiology, UCLA Fielding School of Public Health, 650 S Charles E Young Drive, Los Angeles, CA 90095, USA. Electronic address:
    Introduction: One of the goals of the Global Measles and Rubella Strategic Plan is the reduction in global measles mortality, with high measles vaccination coverage as one of its core components. While measles mortality has been reduced more than 79%, the disease remains a major cause of childhood vaccine preventable disease burden globally. Measles immunization requires a two-dose schedule and only countries with strong, stable immunization programs can rely on routine services to deliver the second dose. Read More

    Dried blood spots: An evaluation of utility in the field.
    J Infect Public Health 2017 Sep 28. Epub 2017 Sep 28.
    Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, MI 48109, USA. Electronic address:
    Background: Use of dried blood spots (DBS) offers advantages over serum samples in studies conducted in resource-poor settings. The aim of this study was to compare the number of adequate spots collected across different demographic groups.

    Methods: Five DBS were collected from 3316 individuals aged 0-49 years in Tianjin, China for a measles antibody study; DBS were rated "adequate" or "inadequate. Read More

    An Outbreak of Measles in a University in Korea, 2014.
    J Korean Med Sci 2017 Nov;32(11):1876-1878
    Seoul Center for Infectious Disease Control, Seoul, Korea.
    Measles has been declared eliminated from the Korea since 2006. In April 2014, a measles outbreak occurred at a University in Seoul. A total of 85 measles cases were identified. Read More

    CHRONOVAC VOYAGEUR: A study of the immune response to yellow fever vaccine among infants previously immunized against measles.
    Vaccine 2017 Oct 25;35(45):6166-6171. Epub 2017 Sep 25.
    Institut Pasteur, Unité de Recherche et d'Expertise Epidémiologie des Maladies Emergentes, Paris, France; Institut Pasteur de Dakar, Unité d'épidémiologie des Maladies Infectieuses, Senegal.
    For administration of multiple live attenuated vaccines, the Advisory Committee on Immunization Practices recommends either simultaneous immunization or period of at least 28days between vaccines, due to a possible reduction in the immune response to either vaccine. The main objective of this study was to compare the immune response to measles (alone or combined with mumps and rubella) and yellow fever vaccines among infants aged 6-24months living in a yellow fever non-endemic country who had receivedmeasles and yellow fever vaccines before travelling to a yellow fever endemic area.

    Subjects And Methods: A retrospective, multicenter case-control study was carried out in 7 travel clinics in the Paris area from February 1st 2011 to march 31, 2015. Read More

    Infant immunization coverage in Italy (2000-2016).
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):231-237
    Direzione Generale della Prevenzione Sanitaria, Ministero della Salute, Rome, Italy.
    Background: In Italy, national-level immunization polices are included in the National Immunization Prevention Plan (PNPV), whose latest edition - 2017-2019 PNPV - was finally approved in February 2017. Coverage rates are a key measure of immunization system performance; it can inform and support national and regional polices' implementation monitoring, as well as measure the impact of interventions aimed at increasing vaccine uptake.

    Methods: We collected, analysed and critically interpreted 2000-2016 Italian national infant immunization coverage trends, by different vaccine, target population, and by Region. Read More

    Detection of human parvovirus B19 in serum samples from children under 5 years of age with rash-fever illnesses in the Democratic Republic of the Congo.
    Int J Infect Dis 2017 Sep 22;65:4-7. Epub 2017 Sep 22.
    University Hospital of Kinshasa, Faculty of Medicine, Department of Microbiology, Kinshasa, Congo; National Institute for Biomedical Research (INRB), Kinshasa, Congo.
    Background: It has been demonstrated that infection with human parvovirus B19 (B19V) is associated with rash-fever illnesses. The present study aimed to investigate B19V as an aetiological agent of rash-fever syndromes in Congolese children confirmed as measles and rubella IgM-negative. An ELISA IgM test and PCR were performed to screen for B19V. Read More

    Risk factors for measles among adults in Tianjin, China: Who should be controls in a case-control study?
    PLoS One 2017 26;12(9):e0185465. Epub 2017 Sep 26.
    Institute of Human Communicable Diseases Control and Prevention, Tianjin Centers for Disease Control and Prevention, Tianjin, China.
    Background: Control groups in previous case-control studies of vaccine-preventable diseases have included people immune to disease. This study examines risk factors for measles acquisition among adults 20 to 49 years of age in Tianjin, China, and compares findings using measles IgG antibody-negative controls to all controls, both IgG-negative and IgG-positive.

    Methods: Measles cases were sampled from a disease registry, and controls were enrolled from community registries in Tianjin, China, 2011-2015. Read More

    Refugee Policy Implications of U.S. Immigration Medical Screenings: A New Era of Inadmissibility on Health-Related Grounds.
    Int J Environ Res Public Health 2017 Sep 24;14(10). Epub 2017 Sep 24.
    Centre for Clinical Epidemiology and Biostatistics (CCEB), School of Medicine and Public Health, The University of Newcastle (UoN), Callaghan, NSW 2308, Australia.
    Refugees frequently face extended delays in their efforts to enter the United States (U.S.) and those who are successful, in many cases, encounter overwhelming obstacles, inadequate resources, and a complex system of legal barriers. Read More

    [Ophthalmological symptoms of measles and their treatment].
    Orv Hetil 2017 Oct;158(39):1523-1527
    Szemészeti Klinika, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Korányi fasor 10-11., 6722.
    Measles, caused by the Morbilli virus, is a highly (about 95 %) contagious disease affecting primarily children, but without proper immunisation, adults can also be infected. The leading symptoms of the disease are high fever that presents after an incubation period of 9-10 days and the red rash that begins several days after the fever starts. Beyond specific generalized symptoms, measles may have ocular symptoms. Read More

    Changes in cause-specific neonatal and 1-59-month child mortality in India from 2000 to 2015: a nationally representative survey.
    • Authors:
    Lancet 2017 Sep 19. Epub 2017 Sep 19.
    Background: Documentation of the demographic and geographical details of changes in cause-specific neonatal (younger than 1 month) and 1-59-month mortality in India can guide further progress in reduction of child mortality. In this study we report the changes in cause-specific child mortality between 2000 and 2015 in India.

    Methods: Since 2001, the Registrar General of India has implemented the Million Death Study (MDS) in 1·3 million homes in more than 7000 randomly selected areas of India. Read More

    Timeliness of Measles Laboratory Reporting and Factors Associated with Delays, Zhejiang Province, China, 2009-2015.
    Health Secur 2017 Sep 22. Epub 2017 Sep 22.
    In 2006, China targeted measles for elimination by 2012, but the goal was not achieved. In line with this goal, the timeliness of measles laboratory reporting should be evaluated to improve efficiency in implementing control measures. Laboratory-confirmed suspected measles cases reported to the measles surveillance system in Zhejiang Province, China, from 2009 to 2015 were collected. Read More

    A Recombinant Measles Vaccine with Enhanced Resistance to Passive Immunity.
    Viruses 2017 Sep 21;9(10). Epub 2017 Sep 21.
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA.
    Current measles vaccines suffer from poor effectiveness in young infants due primarily to the inhibitory effect of residual maternal immunity on vaccine responses. The development of a measles vaccine that resists such passive immunity would strongly contribute to the stalled effort toward measles eradication. In this concise communication, we show that a measles virus (MV) with enhanced hemagglutinin (H) expression and incorporation, termed MVvac2-H2, retained its enhanced immunogenicity, previously established in older mice, when administered to very young, genetically modified, MV-susceptible mice in the presence of passive anti-measles immunity. Read More

    Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 - what is making elimination so difficult?
    Euro Surveill 2017 Sep;22(37)
    Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
    We report an ongoing measles outbreak in Italy, with over 4,400 cases reported in 20 Regions from January to August 2017. Median age was 27 years, 88% of the cases were unvaccinated. The highest incidence was in infants below one year of age and 7% of cases occurred among healthcare workers. Read More

    Efficacy of recombinant measles virus expressing highly pathogenic avian influenza virus (HPAIV) antigen against HPAIV infection in monkeys.
    Sci Rep 2017 Sep 20;7(1):12017. Epub 2017 Sep 20.
    Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
    Highly pathogenic avian influenza virus (HPAIV) is a serious threat not only to domestic fowls but also to humans. Vaccines inducing long-lasting immunity against HPAIV are required. In the present study, we generated recombinant measles virus (MV) expressing the hemagglutinin protein of HPAIV without the multibasic site necessary for its pathogenicity in chickens using the backbone of an MV vaccine strain (rMV-Ed-H5HA) or a wild-type MV-derived mutant (rMV-HL-Vko-H5HA). Read More

    Risk activities and pre-travel health seeking practices of notified cases of imported infectious diseases in Australia.
    J Travel Med 2017 Sep;24(5)
    School of Public Health and Community Medicine, UNSW Sydney, Sydney, New South Wales 2052, Australia.
    Background: Travellers are at risk of acquiring infectious diseases during travel, with risks differing by destination, travel and traveller characteristics. A pre-travel health consultation may minimize this risk. However, uptake of pre-travel health advice remains low. Read More

    Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.
    Nat Commun 2017 Sep 19;8(1):599. Epub 2017 Sep 19.
    23andMe, Mountain View, CA, 94041, USA.
    Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P < 5 × 10(-8)) associations in genes with key roles in immunity and embryonic development. Read More

    1 OF 532