27,671 results match your criteria Measles Rubeola


Measles Virus-Based Treatments Trigger a Pro-inflammatory Cascade and a Distinctive Immunopeptidome in Glioblastoma.

Mol Ther Oncolytics 2019 Mar 31;12:147-161. Epub 2018 Dec 31.

Interdisciplinary Division of Neuro-Oncology, Hertie Institute for Clinical Brain Research, Departments of Neurology and Neurosurgery, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen 72076, Germany.

Glioblastoma is an aggressive primary brain tumor with bad prognosis. On the other hand, oncolytic measles virus (MeV) therapy is an experimental glioma treatment strategy with clinical safety and first evidence of anti-tumoral efficacy. Therefore, we investigated the combination of MeV with conventional therapies by cytotoxic survival assays in long-term glioma cell lines LN229, LNZ308, and glioma stem-like GS8 cells, as well as the basal viral infectivity in primary glioblastoma cultures T81/16, T1094/17, and T708/16. Read More

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http://dx.doi.org/10.1016/j.omto.2018.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365369PMC

The Efficacy and Safety of Intralesional Immunotherapy with Measles, Mumps, Rubella Virus Vaccine for the Treatment of Common Warts in Adults.

Indian Dermatol Online J 2019 Jan-Feb;10(1):19-26

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.

Background: Most therapeutic modalities for common warts remain unsatisfactory.

Objectives: To evaluate efficacy and safety of intralesional MMR (measles, mumps, rubella virus) vaccine in the treatment of common warts in adults.

Patients And Methods: There were 110 (M:F = 61:49) patients aged 19-62 years having 1-211 warts over dorsal hands, feet, palms, soles, and periungual skin for 1-252 months. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_142_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362737PMC
February 2019

First Report of a Disease by Rhazes 10 Centuries Ago.

Int J Prev Med 2019 15;10. Epub 2019 Jan 15.

Department of Anesthesiology and Intensive Care Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Abu Bakr Mohammad Ibn Zakariya Al-Razi (865-925 CE), who was known as "Rhazes" in the west, was a famous scientist of medieval ages. He has more than 200 books and treatises. His masterpiece on medicine "" contains around 900 case reports. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_216_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360843PMC
January 2019

Epidemiological characteristics and trends of a Nationwide measles outbreak in Mongolia, 2015-2016.

BMC Public Health 2019 Feb 15;19(1):201. Epub 2019 Feb 15.

Department of Healthcare Administration, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: Mongolia was one of the four countries that received a measles-elimination certificate from the World Health Organization Regional Office for the Western Pacific in 2014. Following the outbreaks in many countries including China, a large measles outbreak occurred in Mongolia in 2015. This study reports 2015-2016 measles outbreak incidence, mortality, and complications, according to time, geographical distribution, and host characteristics. Read More

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http://dx.doi.org/10.1186/s12889-019-6511-0DOI Listing
February 2019

Cyclical adaptation of measles virus quasispecies to epithelial and lymphocytic cells: To V, or not to V.

PLoS Pathog 2019 Feb 15;15(2):e1007605. Epub 2019 Feb 15.

Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States of America.

Measles virus (MeV) is dual-tropic: it replicates first in lymphatic tissues and then in epithelial cells. This switch in tropism raises the question of whether, and how, intra-host evolution occurs. Towards addressing this question, we adapted MeV either to lymphocytic (Granta-519) or epithelial (H358) cells. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007605DOI Listing
February 2019

Status of Measles Elimination in Eleven Countries with High Routine Immunisation Coverage in The WHO African Region.

J Immunol Sci 2018 Jul;Suppl:140-144

WHO Regional Office for Africa, Brazzaville, Congo.

Background: Measles elimination is defined as the absence of endemic measles virus transmission in a defined geographic area for at least 12 months in the presence of a well-performing surveillance system. The WHO framework for verification of measles elimination indicates that the achievement of measles and/or rubella elimination should be verified for individual countries.

Objective: We identified 11 high performing countries based on their first dose measles vaccination coverage, and looked at their performance across the various programmatic parameters, to see if they are ready to undertake the verification of measles elimination. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372061PMC

Introduction of the Second Dose of Measles Containing Vaccine in the Childhood Vaccination Programs Within the WHO Africa Region - Lessons Learnt.

J Immunol Sci 2018 Jul;Suppl:113-121

WHO Inter-country Support Team for Western Africa. Ouagadougou, Burkina Faso.

Background: WHO recommends all countries to include a second routine dose of measles containing vaccine (MCV2) in their national routine vaccination schedules regardless of the level of coverage with the first routine dose of measles containing vaccine (MCV1). As of Dec 2016, 26 countries in the African Region have introduced MCV2.

Methods: We reviewed the WHO UNICEF coverage estimates for MCV1 and MCV2 in these countries, and the reports of the post introduction evaluation of MCV2 from 11 countries. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372060PMC
July 2018
2 Reads

Measles epidemic in Ukraine drove troubling European year.

Authors:
Meredith Wadman

Science 2019 02;363(6428):677-678

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http://dx.doi.org/10.1126/science.363.6428.677DOI Listing
February 2019

Philippines measles outbreak is deadliest yet as vaccine scepticism spurs disease comeback.

Authors:
Owen Dyer

BMJ 2019 Feb 14;364:l739. Epub 2019 Feb 14.

Montreal, Canada.

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http://dx.doi.org/10.1136/bmj.l739DOI Listing
February 2019

Long-term protection against varicella with two-dose combination measles-mumps-rubella-varicella vaccine.

Lancet Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

National Centre for Immunisation Research and Surveillance, Westmead, NSW 2145, Australia. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30797-7DOI Listing
February 2019

Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine or one dose of monovalent varicella vaccine: 10-year follow-up of a phase 3 multicentre, observer-blind, randomised, controlled trial.

Lancet Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

University of Defence, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic; Charles University, Faculty of Medicine in Hradec Kralove, Department of Social Medicine, Hradec Kralove, Czech Republic.

Background: The duration of protection provided by varicella vaccines is unclear. We assessed the 10-year vaccine efficacy of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV), one live attenuated varicella vaccine (V) dose given after one measles-mumps-rubella vaccine (MMR) dose (MMR + V), versus two MMR doses (control vaccine) for the prevention of confirmed varicella.

Methods: This was a phase 3b follow-up of an observer-blinded, randomised, controlled trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14733099183071
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http://dx.doi.org/10.1016/S1473-3099(18)30716-3DOI Listing
February 2019
3 Reads

Early disappearance of maternal anti-measles, mumps, rubella, and varicella antibodies in Indian infants.

Vaccine 2019 Feb 11. Epub 2019 Feb 11.

Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed To Be University), Pune, India. Electronic address:

Background: Immunization of children with vaccines against Measles, Mumps, Rubella, and Varicella (MMRV) is practiced globally with varied recommendations. In India, measles vaccine is administered alone or as MMR at 9 months age. Varicella vaccine is not routinely used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193011
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http://dx.doi.org/10.1016/j.vaccine.2019.01.043DOI Listing
February 2019
1 Read

Immunization coverage and factors associated with incomplete vaccination in children aged 12 to 59 months in health structures in Lomé.

BMC Res Notes 2019 Feb 14;12(1):84. Epub 2019 Feb 14.

Département de Pédiatrie, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo.

Objective: To estimate the immunization coverage among children admitted for consultation or hospitalization in health structures of Lomé.

Results: A total of 797 respondent-child couples were included and 31.1% of them had their immunization cards. Read More

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http://dx.doi.org/10.1186/s13104-019-4115-5DOI Listing
February 2019

Measles outbreaks in Italy: A paradigm of the re-emergence of vaccine-preventable diseases in developed countries.

Authors:
Alessandro Siani

Prev Med 2019 Feb 11. Epub 2019 Feb 11.

School of Biological Sciences, University of Portsmouth, Portsmouth, UK. Electronic address:

Over the last decade, outbreaks of vaccine-preventable diseases have been reported in developed countries around the world. In particular, measles outbreaks have been ongoing in the European Union since 2017, with the majority of cases concentrated in Romania and Italy. Measles has been identified as a powerful indicator of the status of vaccination programs in a region, as outbreaks have been reported to quickly emerge as a result of underlying problems in the immunisation routine. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.02.011DOI Listing
February 2019

Effect of Schistosoma mansoni infection and its treatment on antibody responses to measles catch-up immunisation in pre-school children: A randomised trial.

PLoS Negl Trop Dis 2019 Feb 14;13(2):e0007157. Epub 2019 Feb 14.

Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.

Background: Schistosoma infection is associated with immune modulation that can influence responses to non-schistosome antigens. Vaccine responses may be impaired in S. mansoni-infected individuals. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007157
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http://dx.doi.org/10.1371/journal.pntd.0007157DOI Listing
February 2019
5 Reads

The impact of supplementary immunization activities on routine vaccination coverage: An instrumental variable analysis in five low-income countries.

PLoS One 2019 14;14(2):e0212049. Epub 2019 Feb 14.

Department of Population, Family and Reproductive Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.

Background: Countries deliver vaccines either through routine health services or supplementary immunization activities (SIAs), usually community-based or door-to-door immunization campaigns. While SIAs have been successful at increasing coverage of vaccines in low- and middle-income countries, they may disrupt the delivery of routine health services. We examine the impact of SIAs on routine vaccine coverage in five low-income countries. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212049PLOS
February 2019

Barriers to effective uptake and provision of immunization in a rural district in Uganda.

PLoS One 2019 14;14(2):e0212270. Epub 2019 Feb 14.

Sefako Makgatho Health Sciences University, Pretoria, South Africa.

Introduction: Hoima, one of the largest districts in mid- western Uganda, has persistently performed poorly with low immunization coverage, high immunization drop outs rates and repeated outbreaks of vaccine preventable diseases especially measles. The objectives of this study were to evaluate the state of immunization services and to identify the gaps in immunization health systems that contribute to low uptake and completion of immunization schedules in Hoima District.

Methods: This was a cross sectional mixed methods study, utilizing both qualitative and quantitative approaches. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212270PLOS
February 2019

Measles and the Modern History of Vaccination.

Authors:
Elena Conis

Public Health Rep 2019 Feb 14:33354919826558. Epub 2019 Feb 14.

1 Graduate School of Journalism and Center for Science, Technology, Medicine, and Society, University of California, Berkeley, Berkeley, CA, USA.

The modern era of vaccination was heralded with the licensure of the first 2 measles vaccines in 1963. This new era was distinct from the preceding era of vaccination for 4 main reasons. First, federal leadership in support of immunization at the local level grew. Read More

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http://dx.doi.org/10.1177/0033354919826558DOI Listing
February 2019
1 Read

Evaluation of measles immunity in Turkey: is it still a threat?

Turk J Med Sci 2019 Feb 11;49(1):336-340. Epub 2019 Feb 11.

Background/aim: Measles is one of the important vaccine-preventable diseases with many complications in childhood. This study presents cross-sectional seroepidemiological data, beginning from neonatal cord blood in infants to children under 6 years of age, about waning of measles antibody and tries to suggest the proper time for measles immunization.

Materials And Methods: A total of 564 blood samples consisting of neonatal cord blood and samples taken from infants and children at ages of 6, 9, 24–48, and 49–72 months were analyzed for measles seropositivity in a period of 6 months. Read More

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http://dx.doi.org/10.3906/sag-1809-54DOI Listing
February 2019

SIMULTANEOUS DETECTION AND DIFFERENTIATION BETWEEN WILD-TYPE AND VACCINE MEASLES VIRUS BY A MULTIPLEX REAL-TIME RT-PCR ASSAY.

J Clin Microbiol 2019 Feb 13. Epub 2019 Feb 13.

Provincial Laboratory for Public Health, Calgary, Alberta, Canada

Measles is one of the most contagious viral respiratory infection that was declared eliminated from Canada in 1998, however measles cases and outbreaks still occur every year through re-introduction from other parts of the world. Laboratory confirmation of measles virus (MV) RNA by real-time polymerase chain reaction provides a definitive diagnosis, and molecular analysis to determine the genotype is the only way to distinguish between the wild-type and vaccine strains. This distinction is important since live attenuated vaccine strains are able to replicate in the patient and can be associated with rash and fever but are poorly transmissible if at all. Read More

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http://dx.doi.org/10.1128/JCM.01828-18DOI Listing
February 2019
3.993 Impact Factor

Vaccination Against Measles, Mumps, and Rubella in the Light of Current Epidemic Threats: Unjustified Postponement.

Adv Exp Med Biol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics with Clinical Assessment Unit, Warsaw Medical University, Warsaw, Poland.

A worrying increase in the number of measles cases has been noted recently in Poland, which may have to do with a decreasing proportion of children vaccinated against measles, mumps, and rubella (MMR) in the second year of life (<95%). For many years, MMR vaccination in children has been associated with a fear of allergy to eggs. This study seeks to define the reason and justification for postponing MMR vaccination in a population of children referred to the outpatient specialist immunization clinic. Read More

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http://dx.doi.org/10.1007/5584_2019_344DOI Listing
February 2019

Oncolytic activity of canine distemper virus in canine mammary tubular adenocarcinoma cells.

Vet Comp Oncol 2019 Feb 12. Epub 2019 Feb 12.

The Clinical Department, College of Veterinary Medicine, China Agricultural University, P.R. China.

Canine distemper virus (CDV), bearing a close resemblance to measles virus, represents a promising candidate for oncolytic therapy; however, its application and underlying oncolytic mechanisms in canine mammary carcinoma cells remain to be explored. Here, we found that an attenuated canine distemper vaccine strain, CDV-L, efficiently infected and inhibited the growth of canine mammary tubular adenocarcinoma CIPp cells but not MDCK cells in vitro. Transcriptomic analysis of CDV-L-infected CIPp cells revealed substantially differentially expressed genes in apoptotic and NF-κB signaling pathways. Read More

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http://dx.doi.org/10.1111/vco.12466DOI Listing
February 2019

Timeliness and completeness of routine childhood vaccinations in young children residing in a district with recurrent vaccine-preventable disease outbreaks, Jerusalem, Israel.

Euro Surveill 2019 Feb;24(6)

Chief Scientist, Ministry of Health, Jerusalem, Israel.

BackgroundChildhood vaccination schedules recommend vaccine doses at predefined ages.AimWe evaluated vaccination completeness and timeliness in Jerusalem, a district with recurrent vaccine-preventable disease outbreaks.MethodsVaccination coverage was monitored by the up-to-date method (vaccination completeness at age 2 years). Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.6.1800004DOI Listing
February 2019

[Vaccination Controversies: An Adult Case of Post-Vaccinal Acute Disseminated Encephalomyelitis].

Acta Med Port 2019 Feb 1;32(1):81-85. Epub 2019 Feb 1.

Departamento de Neurologia. Hospital da Luz. Lisboa. Portugal.

Acute disseminated encephalomyelitis is a rare inflammatory demyelinating multifocal disease of the central nervous system that typically occurs in children following vaccination or exanthematous viral infections and conveys an elevated risk of neurological sequelae unless promptly recognized and treated. We describe an adult case of acute disseminated encephalomyelitis following vaccination against Mumps, Measles and Rubella, presenting with fever and progressive neurological deficits which improved under systemic corticosteroid therapy. Considering the ongoing public debate regarding universal vaccination and the surge of previously controlled infectious diseases, we aim not only to underline the need for a rigorous assessment of vaccination safety on adult patients in order to prevent misguidance of public opinion, but also to alert clinicians for an early diagnosis of acute disseminated encephalomyelitis in these patients, the incidence of which we speculate may be rising. Read More

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http://dx.doi.org/10.20344/amp.9809DOI Listing
February 2019
1 Read

Indian Academy of Pediatrics (IAP) Advisory Committee on Vaccines and Immunization Practices (ACVIP) Recommended Immunization Schedule (2018-19) and Update on Immunization for Children Aged 0 Through 18 Years.

Indian Pediatr 2018 Dec;55(12):1066-1074

Advisory Committee on Vaccines and Immunization Practices (ACVIP), Indian Academy of Pediatrics, India.

Justification: There is a need to revise/review recommendations regarding existing vaccines in view of current developments in vaccinology.

Process: Advisory Committee on Vaccines and Immunization Practices (ACVIP) of Indian Academy of Pediatrics (IAP) reviewed the new evidence, had two meetings, and representatives of few vaccine manufacturers also presented their data. The recommendations were finalized unanimously. Read More

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December 2018
5 Reads

New world origin of canine distemper: Interdisciplinary insights.

Int J Paleopathol 2019 Mar 8;24:266-278. Epub 2019 Feb 8.

Department of Veterinary Biosciences and Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602-7388, USA. Electronic address:

Objective: Canine distemper virus (CDV), human measles virus (HMV), and rinderpest virus (RPV) of cattle are morbilliviruses that have caused devastating outbreaks for centuries. This paper seeks to reconstruct the evolutionary history of CDV.

Materials And Methods: An interdisciplinary approach is adopted, synthesizing paleopathological analysis of 96 Pre-Columbian dogs (750-1470 CE) from the Weyanoke Old Town, Virginia site, with historical reports, molecular analysis and morbilliviral epidemiology. Read More

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http://dx.doi.org/10.1016/j.ijpp.2018.12.007DOI Listing

Multiplicative rates model for recurrent events in case-cohort studies.

Lifetime Data Anal 2019 Feb 8. Epub 2019 Feb 8.

Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, USA.

In large prospective cohort studies, accumulation of covariate information and follow-up data make up the majority of the cost involved in the study. This might lead to the study being infeasible when there are some expensive variables and/or the event is rare. Prentice (Biometrika 73(1):1-11, 1986) proposed the case-cohort study for time to event data to tackle this problem. Read More

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http://dx.doi.org/10.1007/s10985-019-09466-0DOI Listing
February 2019
1 Read

Factors affecting age-appropriate timeliness of vaccination coverage among children in Lebanon.

Gates Open Res 2018 Dec 16;2:71. Epub 2018 Dec 16.

World Health Organization, Geneva, Switzerland.

The effect of immunization does not only depend on its completeness, but also on its timely administration. Routine childhood vaccinations schedules recommend that children receive the vaccine doses at specific ages. This article attempts to assess timeliness of routine vaccination coverage among a sub-sample of children from a survey conducted in 2016. Read More

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http://dx.doi.org/10.12688/gatesopenres.12898.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362301PMC
December 2018
2 Reads

Measles cases in Europe tripled from 2017 to 2018.

Authors:
Jacqui Thornton

BMJ 2019 Feb 7;364:l634. Epub 2019 Feb 7.

London, UK.

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http://dx.doi.org/10.1136/bmj.l634DOI Listing
February 2019

Pattern of noma (cancrum oris) and its risk factors in Northwestern Nigeria: A hospital-based retrospective study.

Ann Afr Med 2019 Jan-Mar;18(1):17-22

Department of Community Health, Usmanu Danfodiyo University, Sokoto, Nigeria.

Background: Noma (cancrum oris) remains the scourge of children and the "face of poverty" in Sub-Saharan Africa. Recent data on the burden of noma and its risk factors are needed for evaluating and redesigning interventions for its prevention and control.

Objectives: This study aimed to determine the pattern of noma and its risk factors in Northwestern Nigeria. Read More

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http://dx.doi.org/10.4103/aam.aam_5_18DOI Listing
February 2019

Comparison of the whole genome sequence of an Oka varicella vaccine from China with other Oka vaccine strains reveals sites putatively critical for vaccine efficacy.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

NHC Key Laboratory of Medical Virology and Viral Diseases (National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention), WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing 102206, People's Republic of China.

Varicella-Zoster Virus (VZV) infection results in varicella mostly in children. Reactivation of the virus causes Herpes Zoster (HZ) mostly in adults. A live attenuated vaccine (vOka-Biken hereafter) was originally derived from the parental strain pOka. Read More

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http://dx.doi.org/10.1128/JVI.02281-18DOI Listing
February 2019
1 Read

Regulation of HCV infection by Cellular Retinoic Acid Binding Proteins through the modulation of lipid droplet abundance.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Department of Medicine, Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

Retinoid (vitamin A) is an essential diet constituent that governs a broad range of biological processes. Its biologically active metabolite, all-trans retinoic acid (ATRA), exhibits a potent antiviral property by enhancing both innate and adaptive antiviral immunity against a variety of viral pathogens such as, but not limited to, HIV, RSV, HSV, and measles. Even though the hepatocyte is highly enriched with retinoid and its metabolite, ATRA, it supports the establishment of efficient hepatitis C virus (HCV) replication. Read More

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http://dx.doi.org/10.1128/JVI.02302-18DOI Listing
February 2019

Measles virus bearing MIBE-derived fusion protein is pathogenic after infection via the respiratory route.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Center for Host-Pathogen Interaction, Columbia University Medical Center, New York, USA

A clinical isolate of measles virus (MeV) bearing a single amino acid alteration in the viral fusion protein (F; L454W) was previously identified in two patients with lethal sequelae of MeV central nervous system (CNS) infection. The mutation dysregulated the viral fusion machinery so that the mutated F protein mediated cell fusion in the absence of known MeV cellular receptors. While this virus could feasibly have arisen via intra-host evolution of the wildtype (wt) virus, it was recently shown that the same mutation emerged under the selective pressure of small molecule antiviral treatment. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.01862-18
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http://dx.doi.org/10.1128/JVI.01862-18DOI Listing
February 2019
3 Reads

Iterative Excretion of Human Cosaviruses from Different Genotypes Associated with Combined Immunodeficiency Disorder.

Intervirology 2019 Feb 6:1-8. Epub 2019 Feb 6.

WHO Regional Reference Laboratory for Poliomyelitis and Measles, Laboratory of Clinical Virology, Pasteur Institute of Tunis, University of Tunis El Manar, Tunis,

Background: Human cosaviruses (HCoSVs) are newly discovered enteric viruses in the Picornaviridae family. They have been described in non-polio acute flaccid paralysis, diarrheal patients, and healthy individuals. They remain rarely documented in immunodeficient patients. Read More

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http://dx.doi.org/10.1159/000495182DOI Listing
February 2019
2 Reads

Vaccination and adolescent knowledge: health education and disease prevention.

Cien Saude Colet 2019 Feb;24(2):351-360

Universidade Federal de São João del-Rei. R. Sebastião Gonçalves Coelho 400/sala 207/bl, Chanadour. 35501-296 Divinópolis MG, Brasil.

A cross-sectional study in conjunction with a health extension program was conducted with 605 adolescents aged between 13 and 18 years from 22 public schools in Divinópolis, Brazil. The aim of the study was to determine the vaccination status of the adolescents and their level of knowledge of communicable and vaccine-preventable diseases. Three-stage cluster sampling was used comprising schools, classes, and students. Read More

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http://dx.doi.org/10.1590/1413-81232018242.30812016DOI Listing
February 2019
3 Reads

Immunogenicity and safety of the new MMR vaccine containing measles AIK-C, rubella Takahashi, and mumps RIT4385 strains in Japanese children: a randomized phase I/II clinical trial.

Hum Vaccin Immunother 2019 Feb 6. Epub 2019 Feb 6.

b Japan Vaccine Co., Ltd .

Domestic measles, mumps, and rubella combined (MMR) vaccines were discontinued in 1993 in Japan because of the unexpected high incidence of aseptic meningitis. The introduction of an effective MMR vaccine with lower reactogenicity has been expected. A new MMR vaccine (JVC-001) was developed, using mumps RIT4385 strain in combination with Japanese measles AIK-C strain and rubella Takahashi strain (MR) vaccine. Read More

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http://dx.doi.org/10.1080/21645515.2019.1578591DOI Listing
February 2019
6 Reads

Post-infective bronchiectasis by measles prior infection - A case report.

Respir Med Case Rep 2019 18;26:203-205. Epub 2019 Jan 18.

Pneumology B Unit, University Hospital Center of Coimbra, Coimbra, Portugal.

Bronchiectasis (BE) refers to an abnormal and irreversible dilatation of the bronchi. Post-infectious etiology still remains an important and frequent cause. Associated the anti-vaccine movement, measles resurfaces and with all the outcomes that comes from the disease. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350261PMC
January 2019
2 Reads

Measles vector as a multiple genes delivery platform facilitating iPSC reprogramming.

Gene Ther 2019 Feb 4. Epub 2019 Feb 4.

Department of Molecular Medicine, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.

Induced pluripotent stem cells (iPSCs) provide a unique platform for individualized cell therapy approaches. Currently, episomal DNA, mRNA, and Sendai virus-based RNA reprogramming systems are widely used to generate iPSCs. However, they all rely on the use of multiple (three to six) components (vectors/plasmids/mRNAs) leading to the production of partially reprogrammed cells, reducing the efficiency of the systems. Read More

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http://dx.doi.org/10.1038/s41434-019-0058-7DOI Listing
February 2019
1 Read

Discovery of under immunized spatial clusters using network scan statistics.

BMC Med Inform Decis Mak 2019 Feb 4;19(1):28. Epub 2019 Feb 4.

Biocomplexity Institute & Initiative, University of Virginia, 995 Research Park Boulevard, Charlottesville, VA, 22911, USA.

Background: Clusters of under-vaccinated children are emerging in a number of states in the United States due to rising rates of vaccine hesitancy and refusal. As the measles outbreaks in California and other states in 2015 and in Minnesota in 2017 showed, such clusters can pose a significant public health risk. Prior methods have used publicly-available school immunization data for analysis (except for a few, which use private healthcare patient records). Read More

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https://bmcmedinformdecismak.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12911-018-0706-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360755PMC
February 2019
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Development of Luciferase Immunoprecipitation Systems (LIPS) Assay to Detect IgG Antibodies against Human Respiratory Syncytial Virus G-Glycoprotein.

Vaccines (Basel) 2019 Feb 1;7(1). Epub 2019 Feb 1.

Office of Vaccines Research and Review, CBER, FDA, Silver Spring, MD 20993, USA.

Respiratory syncytial virus (RSV) causes severe lower respiratory tract disease in infants and the elderly. Although there is no licensed vaccine, RSV-F and -G glycoproteins are targets for vaccine development and therapeutics. We developed an assay that can detect anti-RSV-G IgG antibodies, either as a biomarker of natural exposure or immunization. Read More

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http://dx.doi.org/10.3390/vaccines7010016DOI Listing
February 2019
2 Reads

Talk to Patients About: Measles.

Authors:
Sean Price

Tex Med 2018 Apr 1;114(4):43. Epub 2018 Apr 1.

Few Americans today remember when measles was deadly. But before the measles vaccine was introduced in 1963, the disease killed about 2.6 million globally each year. Read More

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Characteristics of measles epidemics in China (1951-2004) and implications for elimination: A case study of three key locations.

PLoS Comput Biol 2019 Feb 4;15(2):e1006806. Epub 2019 Feb 4.

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, United States.

Measles is a highly infectious, severe viral disease. The disease is targeted for global eradication; however, this result has proven challenging. In China, where countrywide vaccination coverage for the last decade has been above 95% (the threshold for measles elimination), measles continues to cause large epidemics. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006806DOI Listing
February 2019
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Understanding Intramolecular Crosstalk in an Intrinsically Disordered Protein.

ACS Chem Biol 2019 Feb 12. Epub 2019 Feb 12.

Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" and Istituto di Biologia e Patologia Molecolari del CNR , Sapienza Università di Roma , 00185 Rome , Italy.

The interaction between N and XD from the measles virus represents a paradigmatic example of molecular recognition between an intrinsically disordered protein and a folded partner. By binding to XD, a small portion of N (classically denoted as MoRE) undergoes a disorder-to-order transition, populating an α-helical structure, while the reminder of the protein remains disordered. Here, we demonstrate an unexpected crosstalk between such a disordered region and the adjacent molecular recognition element (MoRE). Read More

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http://dx.doi.org/10.1021/acschembio.8b01055DOI Listing
February 2019
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Maternal Priming: Bacillus Calmette-Guérin (BCG) Vaccine Scarring in Mothers Enhances the Survival of Their Child With a BCG Vaccine Scar.

J Pediatric Infect Dis Soc 2019 Feb 3. Epub 2019 Feb 3.

Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.

Background And Hypothesis: Maternal priming might enhance the beneficial nonspecific effects (NSEs) of live measles vaccination (MV). Children with a bacillus Calmette-Guérin (BCG) vaccine scar have a lower mortality rate than those without a scar that is not explained by protection against tuberculosis. We examined the hypothesis that BCG scarring would have a stronger effect on a child if the mother also had a BCG scar. Read More

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http://dx.doi.org/10.1093/jpids/piy142DOI Listing
February 2019
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Measles case, immunization coverage and its determinant factors among 12-23 month children, in Bassona Worena Woreda, Amhara Region, Ethiopia, 2018.

BMC Res Notes 2019 Feb 1;12(1):71. Epub 2019 Feb 1.

Department of Nursing, Debre Birhan Health Sciences College, P.O. Box  37, Debre Berhan, Amhara Region, Ethiopia.

Objective: The aims of this study were: (1) to calculate measles vaccination coverage and characterize its determinants, and (2) to qualitatively explore factors associated with reasons associated with not immunization a child.

Result: In this study, the measles immunization coverage was 71.3%. Read More

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http://dx.doi.org/10.1186/s13104-019-4104-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359826PMC
February 2019

Imaging of Oncolytic Measles Virus Propagation with Single-Cell Resolution.

Mol Ther Oncolytics 2019 Mar 15;12:68-78. Epub 2018 Dec 15.

Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Recombinant measles viruses (MVs) have oncolytic activity against a variety of human cancers. However, their kinetics of spread within tumors has been unexplored. We established an intravital imaging system using the dorsal skin fold chamber, which allows for serial, non-invasive imaging of tumor cells and replication of a fusogenic and a hypofusogenic MV. Read More

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http://dx.doi.org/10.1016/j.omto.2018.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348983PMC

Measles, mumps, and rubella: A cross-sectional study of susceptibility to vaccine-preventable diseases among young people in India.

Med J Armed Forces India 2019 Jan 18;75(1):70-73. Epub 2019 Jan 18.

Dean and Deputy Commandant, Armed Forces Medical College, Pune 411040, India.

Background: Global elimination of vaccine preventable diseases, such as measles, mumps and rubella is a priority. Many countries have reported diminishing of antibody titres against these diseases among young population as immunization coverage of adolescents and adults in not monitored. The objective of this study was to determine the susceptibility against measles, mumps and rubella among young adults. Read More

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http://dx.doi.org/10.1016/j.mjafi.2018.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349678PMC
January 2019
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Comprehensive Bioinformatics Analysis of the Immune Mechanism of Dendritic Cells Against Measles Virus.

Med Sci Monit 2019 Feb 1;25:903-912. Epub 2019 Feb 1.

College of Public Health, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China (mainland).

BACKGROUND The purpose of this study was to explore the immune mechanism of dendritic cells (DCs) against measles virus (MV), and to identify potential biomarkers to improve measles prevention and treatment. MATERIAL AND METHODS The gene expression profile of GSE980, which comprised 10 DC samples from human blood infected with MV (RNA was isolated at 3, 6, 12, and 24 h post-infection) and 4 normal DC control samples, was obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between the MV-infected DC samples and the control samples were screened using Genevestigator software. Read More

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http://dx.doi.org/10.12659/MSM.912949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367888PMC
February 2019

Reliability and accuracy of smartphones for paediatric infectious disease consultations for children with rash in the paediatric emergency department.

BMC Pediatr 2019 Jan 31;19(1):40. Epub 2019 Jan 31.

Department of Pediatric Emergency Department, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

Objective: Smartphones and associated messaging applications have become the most common means of communication among health care workers and the general population. The aim of this study was to evaluate the reliability and accuracy of smartphones for the diagnosis of rash in children admitted to emergency departments during the night shift.

Methods: The images of the children who were admitted to the paediatric emergency department with rash were included in this study, and at least two images taken with smartphones by residents or paediatric infectious disease fellows were re-directed to the chief consultant of the Paediatric-Infectious Department via smartphone. Read More

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http://dx.doi.org/10.1186/s12887-019-1416-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354364PMC
January 2019
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Recognition of aerosol transmission of infectious agents: a commentary.

BMC Infect Dis 2019 Jan 31;19(1):101. Epub 2019 Jan 31.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.

Although short-range large-droplet transmission is possible for most respiratory infectious agents, deciding on whether the same agent is also airborne has a potentially huge impact on the types (and costs) of infection control interventions that are required.The concept and definition of aerosols is also discussed, as is the concept of large droplet transmission, and airborne transmission which is meant by most authors to be synonymous with aerosol transmission, although some use the term to mean either large droplet or aerosol transmission.However, these terms are often used confusingly when discussing specific infection control interventions for individual pathogens that are accepted to be mostly transmitted by the airborne (aerosol) route (e. Read More

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http://dx.doi.org/10.1186/s12879-019-3707-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357359PMC
January 2019
1 Read