Growth hormone (GH) - insulin like growth factor 1 (IGF-1) axis hyperactivity on bone fibrous dysplasia in McCune-Albright Syndrome.
- Daniele Tessaris,
- Alison M Boyce,
- Margaret Zacharin,
- Patrizia Matarazzo,
- Roberto Lala,
- Luisa de Sanctis,
- Michael T Collins
Clin Endocrinol (Oxf) 2018 Apr 19. Epub 2018 Apr 19.
Section on Skeletal Disorders and Mineral Homeostasis, NIDCR, NIH, Bethesda, USA.
Context: In fibrous dysplasia (BFD) normal bone and bone marrow are replaced by fibro-osseous tissue, leading to fracture, deformity and pain. BFD may be isolated, or in association with cutaneous hyperpigmentation and/or hyperfunctioning endocrinopathies, termed McCune-Albright syndrome (MAS). GH hypersecretion has been described in 10-20% of MAS-BFD patients. Read More