116,694 results match your criteria Mayo Clinic proceedings. Mayo Clinic[Journal]


The MR Imaging Appearance of Endoscopic Endonasal Skull Base Defect Reconstruction Using Free Mucosal Graft.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Division of Otolaryngology, Albany Medical Center, Albany, New York, 12208, U.S.A.

Objective: At our institution, skull base reconstruction using a free mucosal graft from the nasal cavity floor has been the standardized technique after pituitary adenoma resection via transsellar approach. This study describes the expected appearance of the reconstruction on postoperative MRI scans and assesses its integrity and impact on the sinonasal cavity.

Methods: Fifty patients were selected, and their EMR were reviewed for postoperative course, SNOT-22 scores, and nasal endoscopy reports. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.010DOI Listing
February 2019

Autologous Transplantation for Male Germ Cell Tumors: Improved Outcomes over 3 decades.

Biol Blood Marrow Transplant 2019 Feb 19. Epub 2019 Feb 19.

Medical College of Wisconsin, Milwaukee, WI.

Purpose: The curative potential of autologous hematopoietic cell transplantation (autoHCT) for male germ cell tumors (GCT) is well established. Optimal timing and number (single, ST vs. tandem, TT vs. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.015DOI Listing
February 2019

Effect of Timolol on Aqueous Humor Outflow Facility in Healthy Human Eyes.

Am J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, Mayo Clinic, Rochester, MN. Electronic address:

Purpose: Hyposecretion of aqueous humor has been postulated to adversely affect trabecular meshwork health and outflow resistance. However, the effect of medications that reduce aqueous humor production on outflow facility in living human eyes is unclear. In this study we evaluated the effect of timolol, an aqueous humor flow suppressant, on outflow facility in healthy eyes. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.014DOI Listing
February 2019

AMEE guide no. 123 - How to read studies of educational costs.

Med Teach 2019 Feb 22:1-8. Epub 2019 Feb 22.

j BMJ Learning and Quality , London , United Kingdom of Great Britain and Northern Ireland.

Healthcare and health professions education share many of the same problems in decision making. In both cases, there is a finite amount of resources, and so choices need to be made between alternatives. To navigate the options available requires effective decision making. Read More

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http://dx.doi.org/10.1080/0142159X.2018.1552784DOI Listing
February 2019

The 2018 Chitranjan S. Ranawat, MD Award: Developing and Implementing a Novel Institutional Guideline Strategy Reduced Postoperative Opioid Prescribing After TKA and THA.

Clin Orthop Relat Res 2019 Jan;477(1):104-113

C. C. Wyles, M. Hevesi, R. T. Trousdale, M. W. Pagnano, T. M. Mabry Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA E. R. Trousdale, H. M. Gazelka Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA D. S. Ubl, E. B. Habermann Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Surgical Outcomes Program, Mayo Clinic, Rochester, MN, USA.

Background: Opioid prescription management is challenging for orthopaedic surgeons, and we lack evidence-based guidelines for responsible opioid prescribing. Our institution recently developed opioid prescription guidelines for patients undergoing several common orthopaedic procedures including TKA and THA in an effort to reduce and standardize prescribing patterns.

Questions/purposes: (1) How do opioid prescriptions at discharge and 30-day refill rates change in opioid-naïve patients undergoing primary TKA and THA before and after implementation of a novel prescribing guideline strategy? (2) What patient, surgical, and in-hospital factors influence opioid prescription quantity and refill rate?

Methods: New institutional guidelines for patients undergoing TKA and THA recommend a maximum postoperative prescription of 400 oral morphine equivalents (OME), comparable to 50 tablets of 5 mg oxycodone or 80 tablets of 50 mg tramadol. Read More

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http://dx.doi.org/10.1007/s11999.0000000000000292DOI Listing
January 2019

Infection After Unicompartmental Knee Arthroplasty: A High Risk of Subsequent Complications.

Clin Orthop Relat Res 2019 Jan;477(1):70-77

Nicholas J. Hernandez MD, Stephen M. Petis MD, Arlen D. Hanssen MD, Rafael J. Sierra MD, Matthew P. Abdel MD, Mark W. Pagnano MD, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.

Background: Unicompartmental knee arthroplasty restores function and improves pain in appropriately selected patients. Scant evidence exists regarding the treatment of periprosthetic joint infection (PJI) after unicompartmental knee arthroplasty (UKA).

Questions/purposes: (1) What was the overall survivorship free from reinfection? (2) What is the survivorship free of all-cause revision? (3) What are the Knee Society scores (KSS) and complications after surgical treatment of UKA PJI?

Methods: This retrospective study with data drawn from a longitudinally maintained institutional registry identified 15 UKA PJIs between 1992 and 2014. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000372DOI Listing
January 2019

What Is the Survivorship of Revision Surgery Performed for the Chronically Dislocated THA?

Clin Orthop Relat Res 2019 Feb;477(2):374-379

T. S. Brown, R. J. McLaughlin, D. J. Berry, D. G. Lewallen, R. T. Trousdale, R. J. Sierra, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.

Background: Instability remains one of the most common indications for revision THA. However, little is known about the efficacy of surgery for and the complications associated with revision THA for patients with a chronically dislocated THA, which we define as a dislocation of more than 4 weeks.

Questions/purposes: For patients with a chronically dislocated THA undergoing revision THA, we asked (1) What is the survivorship free from additional revision for these procedures? (2) What complications are associated with revision THA in this setting? (3) What are the clinical outcomes as measured by the Harris hip score in these procedures?

Methods: From 1998 to 2014, 1084 patients who underwent revision THA for instability were reviewed and 33 patients (33 hips) were identified who had a hip that had been dislocated for more than 4 weeks. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000392DOI Listing
February 2019

CORR Insights®: Upshifting the Ipsilateral Proximal Femur May Provide Satisfactory Reconstruction of Periacetabular Pelvic Bone Defects After Tumor Resection.

Authors:
Franklin H Sim

Clin Orthop Relat Res 2018 Sep;476(9):1771-1772

F. H. Sim, Professor of Orthopedic Surgery, Mayo Clinic, Department of Orthopaedic Surgery, Rochester, MN, USA.

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http://dx.doi.org/10.1097/01.blo.0000533632.97540.05DOI Listing
September 2018

Care Transitions Program for High-Risk Frail Older Adults is Most Beneficial for Patients with Cognitive Impairment.

J Hosp Med 2019 Feb 20;14:E1-E8. Epub 2019 Feb 20.

Division of Primary Care Internal Medicine, Mayo Clinic, Rochester, Minnesota.

Background: Although posthospitalization care transitions programs (CTP) are highly diverse, their overall program thoroughness is most predictive of their success.

Objective: To identify components of a successful homebased CTP and patient characteristics that are most predictive of reduced 30-day readmissions.

Design: Retrospective cohort. Read More

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http://dx.doi.org/10.12788/jhm.3112DOI Listing
February 2019

ASSOCIATION BETWEEN RANDALL'S PLAQUE STONE ANCHORS AND RENAL PAPILLARY PITS.

J Endourol 2019 Feb 22. Epub 2019 Feb 22.

Indiana University School of Medicine, Dept. of Urology , 1801 North Senate Blvd. , Suite 220 , Indianapolis, Indiana, United States , 46202 ;

Introduction: Renal papillary pits are commonly encountered during ureteroscopy. The mechanism by which such pits arise is unclear. One hypothesis is that pits represent sites where stones overgrowing Randall's plaque (RP) were dislodged. Read More

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http://dx.doi.org/10.1089/end.2018.0589DOI Listing
February 2019

Low-Gradient Severe Mitral Stenosis: Hemodynamic Profiles, Clinical Characteristics, and Outcomes.

J Am Heart Assoc 2019 Mar;8(5):e010736

1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.

Background Optimal management of patients with severe mitral stenosis ( MS ) and low transmitral gradient is incompletely understood. Methods and Results We examined 101 consecutive patients with severe rheumatic MS (mitral valve area ≤1.5 cm) who underwent balloon valvuloplasty. Read More

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http://dx.doi.org/10.1161/JAHA.118.010736DOI Listing

Efficacy, long-term safety, and impact on quality of life of elobixibat in more severe constipation: Post hoc analyses of two phase 3 trials in Japan.

Neurogastroenterol Motil 2019 Feb 21:e13571. Epub 2019 Feb 21.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Background: In two phase 3 trials, elobixibat, a locally acting ileal bile acid transporter inhibitor, resolved constipation and was well tolerated in Japanese patients with chronic constipation. We analyzed the efficacy, safety, and impact on quality of life (QOL) of elobixibat in patients with symptomatically more severe constipation in the two phase 3 trials.

Methods: This post hoc analysis of elobixibat treatment outcomes included data from a 2-week, randomized, placebo-controlled, phase 3 trial (10 mg/d), and a 52-week, open-label trial (5-15 mg/d) in subgroups with severe constipation defined as ≤2 spontaneous bowel movements (SBMs) and ≤3 Bristol Stool Form Scale score during the second week of the 2-week run-in period. Read More

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http://dx.doi.org/10.1111/nmo.13571DOI Listing
February 2019

Primary Care Provider Continuity Is Associated With Improved Preventive Service Ordering During Brief Visits for Acute Symptoms.

Health Serv Res Manag Epidemiol 2019 Jan-Dec;6:2333392819826262. Epub 2019 Feb 6.

Division of Primary Care Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Background: If a patient presents for an acute care visit and sees their assigned primary care provider (PCP), they may be more likely to receive preventive and other services than a patient not seeing their assigned PCP.

Methods: After exclusion of 2 visits with insufficient information, we reviewed 98 consecutive, outpatient internal medicine 15-minute acute care visits comparing patients seeing their assigned PCP with those seeing a non-PCP provider. The primary outcome, preventive service ordering, was measured in 2 ways: percentage of patient visits with preventive service ordered and the total number of preventive services ordered as a proportion of all preventive service items due for each entire cohort. Read More

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http://dx.doi.org/10.1177/2333392819826262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376498PMC
February 2019

Gastrointestinal Tract Disorders in Older Age.

Can J Gastroenterol Hepatol 2019 17;2019:6757524. Epub 2019 Jan 17.

Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, Serbia.

Considering an increase in the life expectancy leading to a rise in the elderly population, it is important to recognize the changes that occur along the process of aging. Gastrointestinal (GI) changes in the elderly are common, and despite some GI disorders being more prevalent in the elderly, there is no GI disease that is limited to this age group. While some changes associated with aging GI system are physiologic, others are pathological and particularly more prevalent among those above age 65 years. Read More

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http://dx.doi.org/10.1155/2019/6757524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354172PMC
January 2019

Population-level changes in lifestyle risk factors for cardiovascular disease in the Heart of New Ulm Project.

Prev Med Rep 2019 Mar 31;13:332-340. Epub 2019 Jan 31.

Center for Clinical Epidemiology & Population Health, Marshfield Clinic Research Institute, 1000 North Oak Ave, Marshfield, WI, United States of America.

Lifestyle significantly influences development of cardiovascular disease (CVD), but limited data exists demonstrating lifestyle improvements in community-based interventions. This study aims to document how lifestyle risk factors changed at the population level in the context of Heart of New Ulm (HONU), a community-based CVD prevention initiative in Minnesota. HONU intervened across worksites, healthcare and the community/environment to reduce CVD risk factors. Read More

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http://dx.doi.org/10.1016/j.pmedr.2019.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369314PMC

Electronic health record access by patients as an indicator of information seeking and sharing for cardiovascular health promotion in social networks: Secondary analysis of a randomized clinical trial.

Prev Med Rep 2019 Mar 14;13:306-313. Epub 2019 Jan 14.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States of America.

We investigated electronic health record (EHR) access as an indicator of cardiovascular health promotion by patients in their social networks, by identifying individuals who viewed their coronary heart disease (CHD) risk information in the EHR and shared this information in their social networks among various spheres of influence. In a secondary analysis of the Myocardial Infarction Genes trial, Olmsted County MN residents (2013-2015; n = 203; whites, ages 45-65 years) at intermediate CHD risk were randomized to receive their conventional risk score (CRS; based on traditional risk factors) alone or also their genetic risk score (GRS; based on 28 genomic variants). We assessed self-reported and objectively quantified EHR access via a patient portal at three and six months after risk disclosure, and determined whether this differed by GRS disclosure. Read More

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http://dx.doi.org/10.1016/j.pmedr.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365362PMC

Acute pancreatitis associated with intravenous administration of propofol: evaluation of causality in a systematic review of the literature.

Gastroenterol Rep (Oxf) 2019 Feb 6;7(1):13-23. Epub 2018 Nov 6.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.

Acute pancreatitis (AP) associated with intravenous administration of propofol has been described with unknown causal relation. We therefore assessed this causality in a systematic review. Multiple databases were searched on 16 August 2017; studies were appraised and selected by two reviewers based on a priori criteria. Read More

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http://dx.doi.org/10.1093/gastro/goy038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375349PMC
February 2019

Incidence of inflammatory bowel disease by race and ethnicity in a population-based inception cohort from 1970 through 2010.

Therap Adv Gastroenterol 2019 6;12:1756284819827692. Epub 2019 Feb 6.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester MN 55905, USA.

Background: Although inflammatory bowel disease (IBD) has been more predominant in white populations, an increasing incidence of IBD in nonwhites has been reported. We sought to evaluate the incidence rates and temporal trends of IBD by race and ethnicity.

Methods: The resources of the Rochester Epidemiologic Project were used to identify 814 county residents newly diagnosed with IBD from 1970 through 2010. Read More

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http://dx.doi.org/10.1177/1756284819827692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376543PMC
February 2019

Barriers in Latin America for the management of locally advanced breast cancer.

Ecancermedicalscience 2019 22;13:897. Epub 2019 Jan 22.

Departamento de Medicina Oncológica, Oncosalud-AUNA, Lima 15036, Peru.

Breast cancer (BC) is a highly prevalent malignancy in Latin American women, most cases being diagnosed at locally advanced or metastatic stages when options for cancer care are limited. Despite its label as a public health problem in the region, Latin American BC patients face several barriers in accessing standard of care treatment when compared with patients from developed countries. In this review, we analyse the landscape of the four main identified barriers in the region: i) high burden of locally advanced/advanced BC; ii) inadequate access to medical resources; iii) deficient access to specialised cancer care and iv) insufficient BC research in Latin America. Read More

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http://dx.doi.org/10.3332/ecancer.2019.897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372299PMC
January 2019

Novel Pathogenic Variant p.Glu190Lys in a Case of Chronic Pancreatitis.

Front Genet 2019 6;10:46. Epub 2019 Feb 6.

Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, United States.

Mutations in the (serine protease 1) gene encoding human cationic trypsinogen cause hereditary pancreatitis or may be associated with sporadic chronic pancreatitis. The mutations exert their pathogenic effect either by increasing intra-pancreatic trypsinogen activation (trypsin pathway) or by causing proenzyme misfolding and endoplasmic reticulum stress (misfolding pathway). Here we report a novel heterozygous c. Read More

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http://dx.doi.org/10.3389/fgene.2019.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375306PMC
February 2019

An innovative visual acuity chart for urgent and primary care settings: validation of the Runge near vision card.

Eye (Lond) 2019 Feb 21. Epub 2019 Feb 21.

Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.

Objective: We evaluated the Runge card, a near-vision eye chart designed for ease of use, by testing agreement in visual acuity results between it and the Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity chart. As a clinical reference point, we compared the Runge card and an electronic Snellen chart with respect to agreement with ETDRS results.

Methods: Participants consisted of adult eye clinic patient volunteers who underwent a protocol refraction, followed by testing with a Runge card, ETDRS chart, and Snellen chart. Read More

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http://dx.doi.org/10.1038/s41433-019-0372-8DOI Listing
February 2019

Acoustoelasticity Analysis of Transient Waves for Non-Invasive In Vivo Assessment of Urinary Bladder.

Sci Rep 2019 Feb 21;9(1):2441. Epub 2019 Feb 21.

Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine & Science, Rochester, MN, USA.

A non-invasive method for measurement of the bladder wall nonlinear elastic behavior is presented. The method is based on acoustoelasticity modeling of the elasticity changes in bladder tissue modulus at different volumetric strain levels. At each volume, tissue strain is obtained from the real-time ultrasound images. Read More

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http://dx.doi.org/10.1038/s41598-018-38445-yDOI Listing
February 2019

How to prescribe loop diuretics in oedema.

BMJ 2019 Feb 21;364:l359. Epub 2019 Feb 21.

The Dartmouth Institute for Health Policy & Clinical Practice, The Department of Community and Family Medicine, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

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http://dx.doi.org/10.1136/bmj.l359DOI Listing
February 2019

Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.

Haematologica 2019 Feb 21. Epub 2019 Feb 21.

University of Minnesota;

Hematopoiesis is dynamically regulated by metabolic cues in homeostatic and stressed conditions; however, the cellular and molecular mechanisms mediating the metabolic sensing and regulation remain largely obscure. Bone marrow adipose tissue remodels in various metabolic conditions and has been recently proposed as a niche for hematopoietic stem cells after irradiation. Here, we investigated the role of marrow adipose tissue-derived hematopoietic cytokine stem cell factor in unperturbed hematopoiesis by selectively ablating the Kitl gene from adipocytes and bone marrow stroma cells using Adipoq-Cre and Osx1-Cre, respectively. Read More

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http://dx.doi.org/10.3324/haematol.2018.205856DOI Listing
February 2019

Calculation of flexor pollicis longus moment arm for wrist motion in a cadaver model validates the tenodesis effect for therapy.

J Hand Ther 2019 Feb 18. Epub 2019 Feb 18.

Tendon and Soft Tissue Biology Laboratory, Mayo Clinic, Rochester, MN, USA. Electronic address:

Introduction: Synergies of fingers and wrist motion have been incorporated into therapies for finger flexor tendon injuries to improve repair outcomes. Similar synergistic therapy strategies have not been well documented for the thumb.

Purpose Of The Study: The purpose of this study was to investigate the extent to which wrist motion enables a synergistic effect at the thumb in a cadaveric model by measuring flexor pollicis longus excursion and calculating the moment arm of this tendon at the wrist joint. Read More

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http://dx.doi.org/10.1016/j.jht.2019.01.005DOI Listing
February 2019

Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME) cohort.

Alzheimers Dement 2019 Feb 12. Epub 2019 Feb 12.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Introduction: Our primary goal was to examine demographic and clinicopathologic differences across an ethnoracially diverse autopsy-confirmed cohort of Alzheimer's disease cases.

Methods: A retrospective study was conducted in the Florida Autopsied Multi-Ethnic cohort on 1625 Alzheimer's disease cases, including decedents who self-reported as Hispanic/Latino (n = 67), black/African American (n = 19), and white/European American (n = 1539).

Results: Hispanic decedents had a higher frequency of family history of cognitive impairment (58%), an earlier age at onset (median age of 70 years), longer disease duration (median of 12 years), and lower MMSE proximal to death (median of 4 points) compared with the other ethnoracial groups. Read More

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http://dx.doi.org/10.1016/j.jalz.2018.12.013DOI Listing
February 2019

Yoga as Antihypertensive Lifestyle Therapy: A Systematic Review and Meta-analysis.

Mayo Clin Proc 2019 Feb 6. Epub 2019 Feb 6.

Department of Kinesiology, University of Connecticut, Storrs, CT; Institute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, CT.

Objective: To investigate the efficacy of yoga as antihypertensive lifestyle therapy and identify moderators that account for variability in the blood pressure (BP) response to yoga.

Methods: We systematically searched 6 electronic databases from inception through June 4, 2018, for articles published in English language journals on trials of yoga interventions that involved adult participants, reported preintervention and postintervention BP, and had a nonexercise/nondiet control group. Our search yielded 49 qualifying controlled trials (56 interventions). Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.09.023DOI Listing
February 2019

Soft Tissue and Bony Injuries Attributed to the Practice of Yoga: A Biomechanical Analysis and Implications for Management.

Mayo Clin Proc 2019 Feb 6. Epub 2019 Feb 6.

Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN.

Objective: To analyze injuries that were directly associated with yoga practice and identify specific poses that should be avoided in patients with osteopenia or osteoporosis.

Patients And Methods: We retrospectively reviewed the medical records of patients with injuries that were primarily caused by yoga. Patients were seen from January 1, 2006, through December 31, 2018. Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.09.024DOI Listing
February 2019

Yoga, Safe for All?

Mayo Clin Proc 2019 Feb 6. Epub 2019 Feb 6.

Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1016/j.mayocp.2019.01.015DOI Listing
February 2019

Hermansky-Pudlak syndrome and oculocutaneous albinism in Chinese children with pigmentation defects and easy bruising.

Orphanet J Rare Dis 2019 Feb 21;14(1):52. Epub 2019 Feb 21.

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, MSC 1851, Bethesda, MD, 20892-1851, USA.

Background: Determining the etiology of oculocutaneous albinism is important for proper clinical management and to determine prognosis. The purpose of this study was to genotype and phenotype eight adopted Chinese children who presented with oculocutaneous albinism and easy bruisability.

Results: The patients were evaluated at a single center; their ages ranged from 3 to 8 years. Read More

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http://dx.doi.org/10.1186/s13023-019-1023-7DOI Listing
February 2019

Deep Brain Stimulation and Cognitive Outcomes Among Patients With Parkinson's Disease: A Historical Cohort Study.

J Neuropsychiatry Clin Neurosci 2019 Feb 22:appineuropsych18050118. Epub 2019 Feb 22.

From the Translational Neuroscience and Aging Laboratory, Mayo Clinic, Phoenix, Ariz. (Krell-Roesch, Velgos, Geda); the Department of Psychiatry and Psychology, Mayo Clinic, Phoenix, Ariz. (Kirlin, Geda); the Department of Neurological Surgery, Phoenix, Ariz. (Lyons); and the Department of Neurology, Mayo Clinic, Phoenix, Ariz. (Geda, Mehta).

Objective:: Deep brain stimulation (DBS) is an effective treatment for motor symptoms of Parkinson's disease; however, there is conflicting literature about the effect of DBS on cognitive function. The authors conducted a historical cohort study involving patients with Parkinson's disease who underwent DBS of the globus pallidus pars interna (GPi; N=12) or subthalamic nucleus (STN; N=17).

Methods:: The authors investigated differences in four neuropsychological test scores at 6 months post-DBS (follow-up) as compared with baseline (i. Read More

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http://dx.doi.org/10.1176/appi.neuropsych.18050118DOI Listing
February 2019

Essential Roles for the Non-Canonical IκB Kinases in Linking Inflammation to Cancer, Obesity, and Diabetes.

Cells 2019 Feb 19;8(2). Epub 2019 Feb 19.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.

Non-canonical IκB kinases (IKKs) TBK1 and IKKε have essential roles as regulators of innate immunity and cancer. Recent work has also implicated these kinases in distinctively controlling glucose homeostasis and repressing adaptive thermogenic and mitochondrial biogenic response upon obesity-induced inflammation. Additionally, TBK1 and IKKε regulate pancreatic β-cell regeneration. Read More

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http://dx.doi.org/10.3390/cells8020178DOI Listing
February 2019

Construction of a Model Culture System of Human Colonic Microbiota to Detect Decreased Lachnospiraceae Abundance and Butyrogenesis in the Feces of Ulcerative Colitis Patients.

Biotechnol J 2019 Feb 21:e1800555. Epub 2019 Feb 21.

Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo, Japan.

Compositional alteration of the gut microbiota is associated with ulcerative colitis (UC). We established a model culture system for the in vitro human colonic microbiota of UC, which will be helpful for determining medical interventions for the disease. 16S rRNA sequencing confirmed that UC models successfully developed from the fecal inoculum and retained the bacterial species biodiversity of UC feces. Read More

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http://dx.doi.org/10.1002/biot.201800555DOI Listing
February 2019

Flap Reconstruction of Gastrointestinal-to-Genitourinary Fistulas: A 20-Year Experience.

J Reconstr Microsurg 2019 Feb 21. Epub 2019 Feb 21.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota.

Background:  Gastrointestinal-to-genitourinary fistulas may occur secondary to obstetric complications, radiation therapy, cancer without radiation, inflammatory bowel disease, or previous surgery. Flap reconstruction is useful for complex cases refractory to standard techniques, separating the fistula tracts to aid healing. The purpose of this study was to investigate outcomes and risk factors for complications in flap reconstruction of fistulas from several different etiologies performed over a 20-year period. Read More

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http://dx.doi.org/10.1055/s-0039-1679880DOI Listing
February 2019

Trends in Utilization, Mortality, Major Complications and Cost after Total Artificial Heart Implantation in the United States (2009-2015).

Hellenic J Cardiol 2019 Feb 18. Epub 2019 Feb 18.

Division of Cardiovascular Diseases, Section of Heart Failure and Transplant, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Background: Total Artificial Heart (TAH) is a viable bridge to transplant (BTT) strategy for patients with severe biventricular failure, or complex congenital heart disease. These patients have higher mortality and morbidity compared with patients undergoing left ventricular assist device (LVAD) implantation.

Objective: To assess national trends in in-hospital mortality, major complications, cost, length of stay and disposition of patients undergoing TAH implantation. Read More

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http://dx.doi.org/10.1016/j.hjc.2019.02.002DOI Listing
February 2019

Post-Operative Endothelial Cell Density is Associated with Late Endothelial Graft Failure After Descemet Stripping Automated Endothelial Keratoplasty.

Ophthalmology 2019 Feb 18. Epub 2019 Feb 18.

Verdier Eye Center, Grand Rapids, MI.

Purpose: To determine whether preoperative endothelial cell density (ECD) and/or postoperative ECD after Descemet stripping automated endothelial keratoplasty (DSAEK) are associated with late endothelial graft failure (LEGF) in the Cornea Preservation Time Study (CPTS).

Design: Cohort study within multicenter randomized clinical trial.

Participants: 1,007 individuals (1,223 study eyes), mean age 70 years, undergoing DSAEK for Fuchs' dystrophy (94% of eyes) or pseudophakic/aphakic corneal edema (PACE) (6% of eyes) and followed for up to 5 years. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.02.011DOI Listing
February 2019

Catheter based treatments for fibrosing mediastinitis.

Catheter Cardiovasc Interv 2019 Feb 21. Epub 2019 Feb 21.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.

Fibrosing mediastinitis is a rare, often debilitating and potentially lethal disease characterized by an exuberant fibroinflammatory response within the mediastinum. Patients typically present with insidious symptoms related to compression of adjacent structures including the esophagus, heart, airways, and cardiac vessels. Fibrosing mediastinitis is most often triggered by Histoplasmosis infection; however, antifungal and anti-inflammatory therapies are largely ineffective. Read More

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http://dx.doi.org/10.1002/ccd.28152DOI Listing
February 2019

Transapical percutaneous closure of rapidly expanding post-surgical left ventricular outflow tract pseudoaneurysm.

Catheter Cardiovasc Interv 2019 Feb 21. Epub 2019 Feb 21.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.

Left ventricular pseudoaneurysm is an infrequent but potentially fatal complication following cardiac surgery, with spontaneous rupture being the most feared result. Moreover, surgical repair is associated with significant morbidity and mortality. We present a successful transapical percutaneous closure of a post-surgical rapidly expanding left ventricular outflow tract (LVOT) pseudoaneurysm utilizing Amplatz Vascular Plug-II (AVP-II) (St. Read More

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http://dx.doi.org/10.1002/ccd.28154DOI Listing
February 2019

Hemodynamic and clinical response to transseptal mitral valve-in-valve and valve-in-ring.

Catheter Cardiovasc Interv 2019 Feb 21. Epub 2019 Feb 21.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.

Objective: To understand the clinical and hemodynamic response of patients with stenotic versus regurgitant prosthetic mitral valve degeneration to transseptal transcatheter mitral valve-in-ring/-valve replacement (TMVR).

Background: Patients with prosthetic mitral valve repair/replacement failure frequently present high-risk surgical challenges. TMVR has been employed as an alternative to surgery. Read More

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http://dx.doi.org/10.1002/ccd.28149DOI Listing
February 2019

Temporal trends of survival and utilization of mechanical circulatory support devices in patients with in-hospital cardiac arrest secondary to ventricular tachycardia/ventricular fibrillation.

Catheter Cardiovasc Interv 2019 Feb 21. Epub 2019 Feb 21.

Division of Cardiovascular diseases, Department of Medicine, University of Miami-Miller School of Medicine, Miami, Florida.

Background: Pulseless ventricular tachycardia/ventricular fibrillation (VT/VF) is the initial rhythm in a third of in-hospital cardiac arrest patients. Mechanical circulatory support (MCS) device use remains poorly understood in this population.

Methods: We conducted an observational analysis of temporal trends in the utilization of MCS in VT/VF IHCA between January 2008 and December 2014 utilizing the Nationwide Inpatient Sample (NIS) database. Read More

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http://dx.doi.org/10.1002/ccd.28138DOI Listing
February 2019

Hydraulic stimulation of carotid artery baroreceptors as a likely cause of transient asystolic cardiac arrest during diagnostic angiography or surgical endarterectomy.

Catheter Cardiovasc Interv 2019 Feb 21. Epub 2019 Feb 21.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.

We describe two patients-both who underwent general anesthesia-in whom we theorize that hydraulic pressure on carotid artery baroreceptors resulted in transient asystolic cardiac arrest (TACA) during diagnostic or therapeutic procedures. Patient #1 was a 58-year-old female who experienced TACA in response to rapid injection of radiocontrast material into the carotid artery during diagnostic cerebral angiography. Her history was remarkable for aneurysmal subarachnoid hemorrhage at least 13 hr prior to angiography, radiographic evidence of intracranial hypertension, and baseline bradycardia, collectively suggestive of increases in baseline vagal tone. Read More

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http://dx.doi.org/10.1002/ccd.28126DOI Listing
February 2019

A near-haploid clone harboring a BCR/ABL1 gene fusion in an adult patient with newly diagnosed B-lymphoblastic leukemia.

Genes Chromosomes Cancer 2019 Feb 20. Epub 2019 Feb 20.

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

The detection of recurrent genetic abnormalities in B-lymphoblastic leukemia (B-ALL) is critical for risk stratification and therapy-related decisions. Near-haploidy (24-30 chromosomes), a subgroup of hypodiploidy (<46 chromosomes), and BCR/ABL1 gene fusions are both recurrent genetic abnormalities in B-ALL and are considered adverse prognostic findings, although outcomes in BCR/ABL1-positive patients have improved with tyrosine kinase inhibitor therapy. While near-haploid clones are primarily observed in children and rarely harbor structural abnormalities, BCR/ABL1-positive B-ALL is primarily observed in adults. Read More

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http://dx.doi.org/10.1002/gcc.22744DOI Listing
February 2019

Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum 25-Hydroxyvitamin D.

J Bone Miner Res 2019 Feb 21:e3686. Epub 2019 Feb 21.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia and the Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Normal vitamin D homeostasis is critical for optimal health; nevertheless, vitamin D deficiency is a worldwide public health problem. Vitamin D insufficiency is most commonly due to inadequate cutaneous synthesis of cholecalciferol and/or insufficient intake of vitamin D, but can also arise as a consequence of pathological states such as obesity. Serum concentrations of 25(OH)D (calcidiol) are low in obesity, and fail to increase appropriately after vitamin D supplementation. Read More

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http://dx.doi.org/10.1002/jbmr.3686DOI Listing
February 2019

Clinical and Laboratory Features of Autoimmune Hemolytic Anemia Associated with Immune Checkpoint Inhibitors.

Am J Hematol 2019 Feb 20. Epub 2019 Feb 20.

Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA.

Immune checkpoint inhibitors (ICPis) are a novel class of immunotherapeutic agents that have revolutionized the treatment of cancer; however, these drugs can also cause a unique spectrum of autoimmune toxicity. Autoimmune hemolytic anemia (AIHA) is a rare but often severe complication of ICPis. We identified 14 patients from 9 institutions across the US who developed ICPi-AIHA. Read More

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http://dx.doi.org/10.1002/ajh.25448DOI Listing
February 2019

Ocular injury during spine surgery.

Can J Anaesth 2019 Feb 21. Epub 2019 Feb 21.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Purpose: Ocular injury and vision loss are rare complications of surgery. Spine surgery has been identified as particularly high risk for postoperative vision loss; nevertheless, ocular injuries have not been comprehensively assessed in this patient population.

Methods: This historical cohort study assessed incidence, cause, and risk factors of perioperative ocular injury after spine surgery at a tertiary care medical centre from January 1, 2006 through January 31, 2018. Read More

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http://dx.doi.org/10.1007/s12630-019-01323-wDOI Listing
February 2019

Interacting medication use and the treatment effects of apixaban versus warfarin: results from the ARISTOTLE Trial.

J Thromb Thrombolysis 2019 Feb 21. Epub 2019 Feb 21.

Duke Heart Center, Duke Clinical Research Institute, Duke University School of Medicine, Box 3943 DUMC, Durham, NC, 27710, USA.

Warfarin is dependent on multiple hepatic enzymes for metabolism while apixaban is a substrate for P-glycoprotein (P-gp) transport and hepatic CYP3A4 metabolism. The aim of this analysis was to assess the impact of interacting medication use on the treatment effects of apixaban versus warfarin. Outcomes were compared between apixaban and warfarin using Cox proportional hazards modeling according to the use of interacting medications at randomization in ARISTOTLE (n = 18,201). Read More

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http://dx.doi.org/10.1007/s11239-019-01823-yDOI Listing
February 2019

Chronic subdural cortical stimulation for phantom limb pain: report of a series of two cases.

Acta Neurochir (Wien) 2019 Feb 21. Epub 2019 Feb 21.

Departments of Neurologic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.

Phantom limb pain is a complex, incompletely understood pain syndrome that is characterized by chronic painful paresthesias in a previous amputated body part. Limited treatment modalities exist that provide meaningful relief, including pharmacological treatments and spinal cord stimulation that are rarely successful for refractory cases. Here, we describe our two-patient cohort with recalcitrant upper extremity phantom limb pain treated with chronic subdural cortical stimulation. Read More

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http://dx.doi.org/10.1007/s00701-019-03828-1DOI Listing
February 2019

Trauma registry data as a tool for comparison of practice patterns and outcomes between low- and middle-income and high-income healthcare settings.

Pediatr Surg Int 2019 Feb 21. Epub 2019 Feb 21.

Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.

Purpose: There is a lack of data-driven, risk-adjusted mortality estimates for injured children outside of high-income countries (HIC). To inform injury prevention and quality improvement efforts, an upper middle-income country (UMIC) pediatric trauma registry was compared to that of a HIC.

Methods: Clinical data, injury details, and mortality of injured children (< 18 years) hospitalized in two centers (USA and South African (SA)) from 2013 to 2017 were abstracted. Read More

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http://dx.doi.org/10.1007/s00383-019-04453-wDOI Listing
February 2019

Development of a miniature device for emerging deep brain stimulation paradigms.

PLoS One 2019 21;14(2):e0212554. Epub 2019 Feb 21.

Deakin University, School of Engineering, Geelong, Victoria, Australia.

Deep brain stimulation (DBS) is a neuromodulatory approach for treatment of several neurological and psychiatric disorders. A new focus on optimising the waveforms used for stimulation is emerging regarding the mechanism of DBS treatment. Many existing DBS devices offer only a limited set of predefined waveforms, mainly rectangular, and hence are inapt for exploring the emerging paradigm. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212554PLOS
February 2019

Evaluation of a Preoperative Adverse Event Risk Index for Patients Undergoing Head and Neck Cancer Surgery.

JAMA Otolaryngol Head Neck Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

Importance: Patients 65 years or older are the most frequent users of operative resources and are also the most vulnerable to postoperative adverse events (AEs). Frailty indices are increasingly being used for preoperative risk stratification within head and neck cancer surgery, but most models lack a multifactorial basis and cannot be directly applied to clinical practice. A practical risk index is needed for clinicians to gauge risk factors preoperatively. Read More

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http://dx.doi.org/10.1001/jamaoto.2018.4513DOI Listing
February 2019