118,397 results match your criteria Mayo Clinic proceedings. Mayo Clinic[Journal]


The Emerging Role of Nurse Practitioners and Physician Assistants in Liver Transplantation.

Liver Transpl 2019 Apr 23. Epub 2019 Apr 23.

Division of Transplant Medicine, Mayo Clinic, Jacksonville, Florida.

The evolution of nurse practitioners (NP) and physician assistants (PA) in the United States continues to progress. NPs and PAs have expanded from primary care practices, to medical and surgical specialties, provide acute care in hospitals and intensive care units, and serve as educators, lobbyists, and researchers. Questions have arisen from NP/PA leaders, physician leaders, and administrators on how to best implement a successful NP/PA model within their practice. Read More

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http://dx.doi.org/10.1002/lt.25474DOI Listing

The gut-liver axis in PSC: Are pathobionts the missing link?

Hepatology 2019 Apr 23. Epub 2019 Apr 23.

Division of Gastroenterology and Hepatology and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA.

Primary sclerosing cholangitis (PSC) is characterized by progressive fibrosis around intra- and extrahepatic bile ducts that can progress to cirrhosis and liver failure. There are no regulatory drugs approved for PSC and liver transplantation is the only effective therapy(1). While the concentric accumulation of periductular fibrosis suggests the biliary epithelial cell (cholangiocyte) plays an integral role in disease initiation and/or progression, multiple factors from the gut like microbes and their molecular products, endogenous metabolites like bile acids, and primed immune cells have been hypothesized to play a significant role in the hepatobiliary injury and adverse clinical sequelae in PSC. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30673
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http://dx.doi.org/10.1002/hep.30673DOI Listing
April 2019
1 Read

Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome.

PLoS One 2019 23;14(4):e0215997. Epub 2019 Apr 23.

Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Introduction: Measurement of ventilatory efficiency, defined as minute ventilation per unit carbon dioxide production (VE/VCO2), by cardiopulmonary exercise testing (CPET) has been proposed as a screen for hyperventilation syndrome (HVS). However, increased VE/VCO2 may be associated with other disorders which need to be distinguished from HVS. A more specific marker of HVS by CPET would be clinically useful. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215997PLOS
April 2019
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Computed Tomography Data to Generate a Reproducible, Anatomically Accurate Hemilaryngeal Model.

Otolaryngol Head Neck Surg 2019 Apr 23:194599819844974. Epub 2019 Apr 23.

1 Head and Neck Regeneration Program, Center for Regenerative Medicine, Mayo Clinic, Phoenix, Arizona, USA.

Objective: The study aims to demonstrate the reproducibility and feasibility of creating a hemilaryngeal model with a medialized vocal fold (VF) using 3-dimensional (3D) modeling techniques in both healthy larynges and those affected by cancer.

Study Design: Three-dimensional modeling of human larynges.

Setting: Tertiary academic referral center and regenerative medicine laboratory. Read More

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http://dx.doi.org/10.1177/0194599819844974DOI Listing
April 2019
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Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma.

J Clin Oncol 2019 Apr 23:JCO1802374. Epub 2019 Apr 23.

16 Monter Cancer Center, Northwell Health, Lake Success, NY, and Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.

Purpose: SARC024 is a phase II clinical trial of the multikinase inhibitor regorafenib in specific sarcoma subtypes, including advanced osteosarcoma. We hypothesized that regorafenib would improve progression-free survival (PFS) in patients with sarcoma and report the results of the osteosarcoma cohort.

Patients And Methods: This trial enrolled patients with progressive metastatic osteosarcoma with measurable disease by RECIST who had received at least one prior line of therapy. Read More

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http://dx.doi.org/10.1200/JCO.18.02374DOI Listing

Subcutaneous Adipose Tissue Free Fatty Acid Uptake Measured Using Positron Emission Tomography and Adipose Biopsies in Humans.

Am J Physiol Endocrinol Metab 2019 Apr 23. Epub 2019 Apr 23.

Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, United States.

PET radiopharmaceuticals can noninvasively measure free fatty acid (FFA) uptake into adipose tissue. We studied 29 volunteers to test whether abdominal and femoral subcutaneous adipose tissue FFA uptake measured using [1-C]palmitate PET agrees with FFA storage rates measured using an intravenous bolus of [1-C]palmitate and adipose biopsies. The dynamic left ventricular cavity PET images combined with blood sample radioactivity corrected for the CO content were used to create the blood time activity curve (TAC) and the constant (Ki) was determined using Patlak analysis of the TACs generated for regions of interest in abdominal subcutaneous fat. Read More

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http://dx.doi.org/10.1152/ajpendo.00030.2019DOI Listing

Factors associated with prolonged length of stay following robotic-assisted partial nephrectomy.

Can J Urol 2019 Apr;26(2):9726-9732

Department of Urology, Mayo Clinic, Jacksonville, Florida, USA.

Introduction: To prospectively analyze the association of clinical and operative variables on patient length of hospital stay (LOS) following robotic-assisted partial nephrectomy (RAPN) and develop an accurate clinical-based scoring system to predict prolonged LOS following RAPN.

Materials And Methods: We analyzed 304 consecutive RAPNs performed by a single surgeon. Prolonged LOS was defined as greater than 3 days of hospitalization postoperatively. Read More

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Immunotherapy and the Interventional Oncologist: Challenges and Opportunities-A Society of Interventional Oncology White Paper.

Radiology 2019 Apr 23:182326. Epub 2019 Apr 23.

From the Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, H-118, New York, NY 10065 (J.P.E.); Department of Radiology and Imaging Sciences, University of Utah School of Medicine, Salt Lake City, Utah (G.C.F.); Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands (G.J.A., M.d.B.); Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass (M.A.); Division of Vascular and Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.); Department of Radiodiagnostic and Interventional Radiology, University of Lausanne, Lausanne, Switzerland (R.D.); Penn Image-Guided Interventions Laboratory and Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (S.J.H.); Department of Radiology, University of Colorado, Denver, Colo (D.T.J.); Department of Radiology, Ludwig-Maximilian University, Munich, Germany (J.R.); Division of Vascular and Interventional Radiology, Stanford University, Stanford, Calif (D.Y.S.); Division of Interventional Radiology, Mayo Clinic Florida, Jacksonville, Fla (B.B.T.); Center for Interventional Oncology, National Cancer Institute, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (B.J.W.); Department of Radiology, Mayo Clinic, Rochester Minn (D.W.); and Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel (S.N.G.).

Interventional oncology is a subspecialty field of interventional radiology that addresses the diagnosis and treatment of cancer and cancer-related problems by using targeted minimally invasive procedures performed with image guidance. Immuno-oncology is an innovative area of cancer research and practice that seeks to help the patient's own immune system fight cancer. Both interventional oncology and immuno-oncology can potentially play a pivotal role in cancer management plans when used alongside medical, surgical, and radiation oncology in the care of cancer patients. Read More

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http://dx.doi.org/10.1148/radiol.2019182326DOI Listing

Fatal diffuse pulmonary fat microemboli following reperfusion in liver transplantation with the use of marginal steatotic allografts.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Department of Surgery, Division of Transplant Surgery, Mayo Clinic Arizona, Phoenix, Arizona.

Organ shortage is a major cause of delayed liver transplantation and increased wait list time. The level of donor steatosis is a significant determinant in organ selection. Scarcity of organs has led some programs to expand their acceptable criteria for the percentage of steatosis. Read More

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http://dx.doi.org/10.1111/ajt.15399DOI Listing

Time for Reform in Transplant Program Specific Reporting - AST/ASTS Transplant Metrics Taskforce.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Division of Transplantation, University of Minnesota, Minneapolis, Minnesota.

In accordance with the National Organ Transplant Act and HHS's Final Rule, the Scientific Registry of Transplant Recipients (SRTR) publicly releases biannual program-specific reports which include analyses of transplant centers' risk-adjusted wait-list mortality, organ acceptance ratios, transplant rates, and graft and patient survival. Since the inception of these center metrics, one-year post-transplant graft and patient survival have improved, and center variation has decreased, casting uncertainty on their clinical relevance. The SRTR has recently modified center evaluations by ranking centers into 5 tiers rather than 3-tiers in an attempt to discriminate between programs performing within a tight range, further exacerbating this uncertainty. Read More

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http://dx.doi.org/10.1111/ajt.15394DOI Listing

Pharmacogenomics-Driven Prediction of Antidepressant Treatment Outcomes: A Machine Learning Approach with Multi-Trial Replication.

Clin Pharmacol Ther 2019 Apr 23. Epub 2019 Apr 23.

Dept. of Psychiatry & Psychology, Mayo Clinic, Jacksonville, FL.

We set out to determine whether machine learning-based algorithms that included functionally validated pharmacogenomic biomarkers joined with clinical measures could predict selective serotonin reuptake inhibitor (SSRI) remission/response in patients with major depressive disorder (MDD). We studied 1,030 Caucasian MDD outpatients treated with citalopram/escitalopram in the PGRN-AMPS (n = 398), STAR*D (n = 467), and ISPC (n = 165) trials. GWAS for PGRN-AMPS plasma metabolites associated with SSRI response (serotonin) and baseline MDD severity (kynurenine) identified SNPs in DEFB1, ERICH3, AHR, and TSPAN5 that we tested as predictors. Read More

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http://dx.doi.org/10.1002/cpt.1482DOI Listing

Ethanol induces maladaptive impulse control and decreased seeking behaviors in mice.

Addict Biol 2019 Apr 22:e12754. Epub 2019 Apr 22.

Neuroscience Program, Mayo Clinic College of Medicine Rochester, Rochester, Minnesota.

Waiting impulsivity is a risk factor for many psychiatric disorders including alcohol use disorder (AUD). Highly impulsive individuals are vulnerable to alcohol abuse. However, it is not well understood whether chronic alcohol use increases the propensity for impulsive behavior. Read More

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http://dx.doi.org/10.1111/adb.12754DOI Listing

POEMS Syndrome: update on diagnosis, risk-stratification, and management.

Am J Hematol 2019 Apr 22. Epub 2019 Apr 22.

Professor of Medicine and Laboratory Medicine, Mayo Clnic.

Disease Overview: POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Read More

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http://dx.doi.org/10.1002/ajh.25495DOI Listing

Association of Final Discharge Blood Pressure with Post-discharge Outcomes Using Electronic Medical Record Data: a Retrospective Study.

J Gen Intern Med 2019 Apr 22. Epub 2019 Apr 22.

University of Minnesota Medical Center, Mayo Mail Code 741, 420 Delaware St SE, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1007/s11606-019-04981-0DOI Listing

Recurrence of Melanoma After a Negative Sentinel Node Biopsy: Predictors and Impact of Recurrence Site on Survival.

Ann Surg Oncol 2019 Apr 22. Epub 2019 Apr 22.

Oregon Health and Science University, Portland, OR, USA.

Background: Factors that predict melanoma recurrence after a negative sentinel lymph node biopsy (SLNB) are not well-defined. We evaluated melanoma recurrence patterns, factors prognostic for recurrence, and the impact of recurrence on outcomes after a negative SLNB.

Methods: The Sentinel Lymph Node Working Group database was evaluated from 1996 to 2016 for negative SLNB melanoma patients. Read More

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http://dx.doi.org/10.1245/s10434-019-07369-wDOI Listing

Social media update: The launch of @JNCjournal.

Authors:
Niti R Aggarwal

J Nucl Cardiol 2019 Apr 22. Epub 2019 Apr 22.

Department of Cardiology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1007/s12350-019-01699-8DOI Listing

Favorable pharmacokinetics in hemophilia B for nonacog beta pegol versus recombinant factor IX-Fc fusion protein: A randomized trial.

Res Pract Thromb Haemost 2019 Apr 23;3(2):268-276. Epub 2019 Mar 23.

Department for Internal Medicine Vascular Medicine and Haemostaseology Vivantes Klinikum Berlin Germany.

Background And Objective: Nonacog beta pegol (N9-GP) and recombinant factor IX-Fc fusion protein (rFIXFc) are extended half-life rFIX compounds. We report the first single-dose pharmacokinetic trial of N9-GP and rFIXFc.

Patients/methods: Paradigm 7 was a multicenter, open-label, randomized, crossover trial in previously treated (>150 exposure days) adults with congenital hemophilia B (FIX activity ≤2%). Read More

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http://doi.wiley.com/10.1002/rth2.12192
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http://dx.doi.org/10.1002/rth2.12192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462750PMC
April 2019
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Long-term Clinical Outcomes and Safety Profile of SBRT for Centrally Located NSCLC.

Adv Radiat Oncol 2019 Apr-Jun;4(2):422-428. Epub 2019 Jan 24.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Purpose: Previous studies suggest that stereotactic body radiation therapy (SBRT) is associated with higher toxicity rates for central lung tumors relative to peripheral tumors when using 3 fraction SBRT. The initial results from Radiation Therapy Oncology Group study 0813 suggest a safe toxicity profile of SBRT administered in 5 fractions for central non-small cell lung cancer (NSCLC). We reviewed our institutional data to evaluate the safety and efficacy of SBRT for central NSCLC. Read More

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http://dx.doi.org/10.1016/j.adro.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460233PMC
January 2019

Single-fraction Stereotactic Body Radiation Therapy versus Conventionally Fractionated Radiation Therapy for the Treatment of Prostate Cancer Bone Metastases.

Adv Radiat Oncol 2019 Apr-Jun;4(2):314-322. Epub 2019 Feb 19.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Purpose: This study aimed to compare outcomes of patients with prostate cancer with bone metastases treated with stereotactic body radiation therapy (SBRT) versus conventionally fractionated radiation therapy (CFRT).

Methods And Materials: An institutional, retrospective review was conducted of patients with prostate cancer receiving radiation therapy to bone metastases. In-field failure (IFF) was the primary outcome of the study, and distant failure (DF) and biochemical failure (BF) were secondary outcomes. Read More

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http://dx.doi.org/10.1016/j.adro.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460234PMC
February 2019

Recurrent Radiation Recall Mucosal Toxicity of the Upper Aerodigestive Tract: A Case Report.

Adv Radiat Oncol 2019 Apr-Jun;4(2):229-232. Epub 2018 Nov 14.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1016/j.adro.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460096PMC
November 2018

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.

Alzheimers Dement (N Y) 2019 9;5:107-117. Epub 2019 Apr 9.

Molecular & Clinical Sciences Research Institute, St George's University of London and Department of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK.

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23528737193000
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http://dx.doi.org/10.1016/j.trci.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461571PMC
April 2019
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Adermatoglyphia: Barriers to Biometric Identification and the Need for a Standardized Alternative.

Authors:
Nuraiz Sarfraz

Cureus 2019 Feb 8;11(2):e4040. Epub 2019 Feb 8.

Internal Medicine, King Edward Medical University/Mayo Hospital, Faisalabad, PAK.

Arguably, fingerprinting is the single most widely utilized method for individual identification and authentication (I&A). Dermatoglyphics form a vital portion of mass data collection, biometric scrutiny, and verification. Adermatoglyphia, or simply, loss of fingerprints attributed to a medical cause, represents a taxing situation for such biometric scrutiny systems requiring a fingerprint scan as a mandatory phase in I&A procedure. Read More

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http://dx.doi.org/10.7759/cureus.4040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456356PMC
February 2019

Prognostic value of B7-H1, B7-H3 and the stage, size, grade and necrosis (SSIGN) score in metastatic clear cell renal cell carcinoma.

Cent European J Urol 2019 14;72(1):23-31. Epub 2019 Mar 14.

Department of Urology, Medical University of Graz, Graz, Austria.

Introduction: We compared the potential prognostic impact of B7-H1 and B7-H3 glycoprotein expressions with the Mayo Clinic Stage, Size, Grade, and Necrosis (SSIGN) score in metastatic clear cell renal cell carcinoma (mccRCC) during a long term follow-up.

Material And Methods: We investigated 44 mccRCC patients, who underwent radical nephrectomy between 1995 and 2006 at a single tertiary academic center and received interferon therapy (IFNT) for at least three months. The SSIGN score was applied as a validated prediction outcome model. Read More

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http://dx.doi.org/10.5173/ceju.2018.1858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469004PMC

Treatment of Portopulmonary Hypertension With Macitentan in Patients With Cirrhosis.

Authors:
Michael J Krowka

Gastroenterol Hepatol (N Y) 2019 Feb;15(2):108-110

Professor of Medicine Consultant, Division of Gastroenterology/Hepatology and Division of Pulmonary/Critical Care Medicine Mayo Clinic Rochester, Minnesota.

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February 2019

The Management of Older Adults with Pancreatic Adenocarcinoma.

Geriatrics (Basel) 2018 Nov 26;3(4). Epub 2018 Nov 26.

Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.

Pancreatic cancer is the eleventh most common cancer, yet it is the third leading cause of mortality. It is also largely a disease of older adults, with the median age of 71 at diagnosis in the US, with <1% of diagnoses occurring prior to age 50. Current NCCN guidelines recommend surgery for localized disease, followed by adjuvant therapy and/or consideration of enrollment in a clinical trial. Read More

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http://dx.doi.org/10.3390/geriatrics3040085DOI Listing
November 2018

Illness Representation and Self-Care Ability in Older Adults with Chronic Disease.

Geriatrics (Basel) 2018 Jul 31;3(3). Epub 2018 Jul 31.

Department of Nursing, Mayo Clinic, Rochester, MN 55905, USA.

Chronic illness affects >50% of adults in the United States and accounts for >80% of healthcare spending. The purpose of this study was to determine whether beliefs about one's chronic disease (illness representation) are associated with self-care activation, emergency department (ED) visits, or hospitalizations. Using a cross-sectional design, we recruited older adults with heart failure, chronic obstructive pulmonary disease (COPD), and chronic kidney disease. Read More

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http://www.mdpi.com/2308-3417/3/3/45
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http://dx.doi.org/10.3390/geriatrics3030045DOI Listing
July 2018
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Teaching NeuroImages: Congenital variant misdiagnosed as cerebral venous sinus thrombosis: Clinical pitfall.

Neurology 2019 Apr;92(17):e2064-e2065

From the Department of Neurology (S.D., C.B.O.), Division of Neuro-Ophthalmology, Department of Ophthalmology (M.D.A.), and Mayo Clinic School of Medicine (D.M.D.), Mayo Clinic, Scottsdale, AZ.

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http://dx.doi.org/10.1212/WNL.0000000000007372DOI Listing

Lineage-specific alterations in gynecologic neoplasms with choriocarcinomatous differentiation: implications for origin and therapeutics.

Clin Cancer Res 2019 Apr 22. Epub 2019 Apr 22.

Pathology, Johns Hopkins University.

Purpose: Choriocarcinoma is most commonly gestational (androgenetic or biparental) but can be of germ cell origin or can develop as a component of a somatic neoplasm (genetically related to the patient). The latter type are aggressive neoplasms for which the underlying genetic alterations are not well-characterized.

Experimental Design: To investigate the relationship between the different components of somatic neoplasms with choriocarcinomatous elements, the genetic differences between gestational and non-gestational tumors, and identify potential targetable alterations, we analyzed 23 samples from 11 tumors, including 5 gynecologic-type somatic neoplasms with choriocarcinomatous differentiation (2-3 different components each) and 6 pure choriocarcinomas, for somatic mutations, single nucleotide polymorphisms and PD-L1 expression. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-4278DOI Listing

Vaginal Diazepam for Nonrelaxing Pelvic Floor Dysfunction: The Pharmacokinetic Profile.

J Sex Med 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology. Mayo Clinic College of Medicine, Rochester, MN, USA. Electronic address:

Background: Vaginal diazepam is frequently used to treat pelvic floor tension myalgia and pelvic pain despite limited knowledge of systemic absorption.

Aim: To determine the pharmacokinetic and adverse event profile of diazepam vaginal suppositories.

Methods: We used a prospective pharmacokinetic design with repeated assessments of diazepam levels. Read More

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http://dx.doi.org/10.1016/j.jsxm.2019.03.003DOI Listing

Initial Experience with da Vinci Single-port Robot-assisted Radical Prostatectomies.

Eur Urol 2019 Apr 19. Epub 2019 Apr 19.

Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Single-port robotic surgery is being adopted for various surgical procedures. There have been interest in and clinical use of single-port robot-assisted radical prostatectomy (spRARP), but little reported data on feasibility and early outcomes.

Objective: To describe our institution's initial experience with spRARP utilizing the da Vinci single-port (SP) robotic system. Read More

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http://dx.doi.org/10.1016/j.eururo.2019.04.001DOI Listing

Teen Crash Risk and Insufficient Sleep.

J Adolesc Health 2019 May;64(5):671

University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jadohealth.2019.01.025DOI Listing

Serum levels of DNAJB9 are elevated in fibrillary glomerulonephritis patients.

Kidney Int 2019 May 1;95(5):1269-1272. Epub 2019 Mar 1.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Fibrillary glomerulonephritis (FGN) is a rare glomerular disease. Kidney biopsy is required to establish the diagnosis. Recent studies have identified abundant glomerular deposition of DNAJB9 as a unique histological marker of FGN. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.024DOI Listing

A Coronary Conundrum: Papillary Muscle Rupture and Ischemic Mitral Regurgitation Secondary to Coronary Thromboembolism in Antiphospholipid Syndrome.

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619842247

1 Mayo Clinic Arizona, Phoenix, AZ, USA.

Antiphospholipid syndrome (APS) is an autoimmune disorder that has a strong propensity for a hypercoagulable state and is known to be associated with venous and arterial thromboembolism. We describe an uncommon case of APS in the setting of non-Hodgkin's lymphoma, with thromboembolism, and a rare complication after an uncommon etiology of myocardial infarction. This case highlights the importance of early and appropriate type of anticoagulation to reduce the morbidity and mortality in patients with APS. Read More

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http://dx.doi.org/10.1177/2324709619842247DOI Listing

Introduction to Disability and Health for Preclinical Medical Students: Didactic and Disability Panel Discussion.

MedEdPORTAL 2016 Jul 21;12:10429. Epub 2016 Jul 21.

Associate Professor of Medicine, Division of Internal Medicine, Mayo Clinic.

Introduction: Millions of American patients have a disability, and their health care outcomes depend on the attitudes of their health care providers towards persons with disabilities. Overly negative health care provider attitudes lead to significant misunderstandings about what it means to have a disability, inappropriate assumptions, and poor care. However, very few medical schools teach about disability. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464457PMC

Online Module to Improve Emergency Department Observation Unit Practice.

MedEdPORTAL 2016 Jul 8;12:10423. Epub 2016 Jul 8.

Associate Professor of Emergency Medicine, Mayo Clinic.

Introduction: The emergency department (ED) observation unit has become a unique practice opportunity to liberate inpatient capacity in the United States. Substantial variations in clinical practice and level of comfort among ED providers existed in a large health care system. We aimed to study the effectiveness of an educational module targeted for emergency medicine providers. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464449PMC

Exploring the Roles of Central and Peripheral Nervous System Function in Gait Stability: Preliminary Insights from Cancer Survivors.

Gait Posture 2019 Apr 6;71:62-68. Epub 2019 Apr 6.

Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, USA; School of Health & Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA.

Background: Impairments in central and/or peripheral nervous systems are known to be associated with altered gait; however, the interplay between cognitive function, peripheral sensation, and orbital gait stability remains largely unclear. Elucidating these relationships is expected to provide a clearer understanding of potential fall risk factors across various populations and targets for novel interventions. Many patients diagnosed with cancer are treated with chemotherapy agents known to be neurotoxic to the central and/or peripheral nervous systems that can contribute to movement deficiencies, making this population a novel model to investigate these relationships. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09666362183163
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http://dx.doi.org/10.1016/j.gaitpost.2019.04.002DOI Listing
April 2019
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Lung Cancer Risk in Never Smokers of European Descent is Associated with Genetic Variation in the 515.33 TERT-CLPTM1L Region.

J Thorac Oncol 2019 Apr 19. Epub 2019 Apr 19.

Geisel School of Medicine at Dartmouth, 1 Medical Center Dr, Lebanon, NH 03756, USA. Electronic address:

Introduction: Inherited susceptibility to lung cancer risk in never smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study (GWAS) on the largest, to date, set of European-descent never smokers with lung cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15560864193028
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http://dx.doi.org/10.1016/j.jtho.2019.04.008DOI Listing
April 2019
5 Reads

Optimal Lymph Nodes Examination and Adjuvant Chemotherapy for Stage I Lung Cancer.

J Thorac Oncol 2019 Apr 19. Epub 2019 Apr 19.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University, Shanghai, China. Electronic address:

Purpose: To determine the optimal number of lymph nodes (LNs) examined and role of adjuvant chemotherapy in stage I lung cancer.

Methods: The National Cancer Database was queried for surgically-treated patients with pathologic stage I lung cancer between 2006 and 2014 (n=65,438). The optimal LN numbers were determined in the multivariate Cox model, and were further validated in clinical stage I cohort (n=117,112) in terms of nodal upstaging and prognostic stratification. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15560864193029
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http://dx.doi.org/10.1016/j.jtho.2019.03.027DOI Listing
April 2019
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Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Boston Children's Hospital, Boston, MA. Electronic address:

Background & Aims: Fecal microbiota transplantation (FMT) is commonly used to treat Clostridium difficile infection (CDI). CDI is an increasing cause of diarrheal illness in pediatric patients, but the effects of FMT have not been well studied in children. We performed a multi-center retrospective cohort study of pediatric and young adult patients to evaluate the efficacy, safety, and factors associated with a successful FMT for the treatment of CDI. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.037DOI Listing

Surgical Treatment of Lipomatosis of Nerve: A Systematic Review.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurologic Surgery, University of Utah, Salt Lake City, Utah 84132.

Background: Lipomatosis of nerve (LN) is one part of spectrum of adipose lesions of nerve. Nerve-territory overgrowth is present in approximately 62% of cases. Given the wide variability in published reports, there is substantial need to understand the results of surgical treatment and outcomes in this disorder. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193110
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http://dx.doi.org/10.1016/j.wneu.2019.04.110DOI Listing
April 2019
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Effect Of Fetal Posterior Circulation On Efficacy Of Flow Diversion For Treatment Of Posterior Communicating Artery Aneurysms: A Multi-Instutional Study.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA; Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Background: Flow diversion (FD) has emerged as an effective treatment modality for aneurysms of the posterior communicating artery (PCOM). Whether or not a fetal posterior circulation (FPC) affects PCOM aneurysm occlusion rates after FD remains undetermined.

Methods: We performed a retrospective cohort study in which treatment outcomes for FD of PCOM aneurysms from multiple institutions were reviewed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193110
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http://dx.doi.org/10.1016/j.wneu.2019.04.112DOI Listing
April 2019
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Modified GoPro Hero 6 and 7 for Intraoperative Surgical Recording-Transformation Into a Surgeon-Perspective Professional Quality Recording System.

J Oral Maxillofac Surg 2019 Mar 27. Epub 2019 Mar 27.

Chief, Division of Head and Neck Surgery; Program Director, Head and Neck Oncologic Surgery and Microvascular Fellowship; Associate Department Chair and Professor, Department of Oral and Maxillofacial Surgery, University of Florida College of Medicine-Jacksonville, Jacksonville, FL.

Recent innovations in wearable action cameras with high-definition video recording enable surgeons to use cameras for their surgical procedures. In this study, the GoPro HERO 6 (and 7) Black edition camera was modified step by step to allow for a completely wireless surgeon-perspective recording with a battery life and memory capacity never previously obtained with such a high level of digital video quality. With this system, a surgeon can record for more than 14 hours 26 minutes in 1,080 pixels at 60 frames per second without breaking scrub and capture the operating surgeon's direct view of the field. Read More

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http://dx.doi.org/10.1016/j.joms.2019.03.026DOI Listing

Improved Model Prediction of Glioma Growth Utilizing Tissue-Specific Boundary Effects.

Math Biosci 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Mayo Clinic, Phoenix, AZ, USA.

Kinetic parameter estimates for mathematical models of glioblastoma multiforme (GBM), derived from clinical scans, have been used to predict the occurrence of hypoxia, necrosis, response to radiation therapy, and overall survival. Modeling GBM growth in a cerebral model encounters anatomical boundaries that interfere with model calibration from clinical measurements.

Methods: The effect of boundaries is examined on both spherically symmetric and anatomical models of tumor growth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00255564173060
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http://dx.doi.org/10.1016/j.mbs.2019.04.004DOI Listing
April 2019
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It's Not Your Eyes.

Surv Ophthalmol 2019 Apr 19. Epub 2019 Apr 19.

Departments of Neurology, Ophthalmology, Neurosurgery, Otolaryngology - Head & Neck Surgery, Emergency Medicine The John Hopkins University School of Medicine Baltimore, Maryland.

A 55-year-old woman reported blurred vision while walking, numbness and tingling, contact allodynia, and gait imbalance. Visual acuity was 20/20 in both eyes, but there was a loss of 4 lines with horizontal dynamic visual acuity testing. Ocular motility examination demonstrated spontaneous downbeat nystagmus that increased in lateral gaze with a torsional component and impaired smooth pursuits. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.04.004DOI Listing

Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts.

Clin Transl Gastroenterol 2019 Apr 15. Epub 2019 Apr 15.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Objectives: Expression of prostaglandin biosynthetic pathway enzymes in mucinous pancreatic cysts is unknown. Cyclooxygenase-2 (COX-2) inhibition is a potential cancer chemoprevention strategy for these lesions. We evaluated the expression of COX-2, cytosolic phospholipase A2 (cPLA2), and protein kinase B (AKT) in the epithelium of pancreatic cysts and correlated enzyme expression with aspirin (ASA) use and cyst fluid prostaglandin E2 (PGE2) concentration. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000028DOI Listing
April 2019
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Per-Pass Analysis of Thrombus Composition in Patients With Acute Ischemic Stroke Undergoing Mechanical Thrombectomy.

Stroke 2019 May;50(5):1156-1163

Cerenovus, Galway Neuro Technology Centre, Ireland (S.D., R.M., M.G.).

Background and Purpose- Mechanical thrombectomy may involve multiple attempts to retrieve the occluding thrombus. This study examined the composition of thrombus fragments retrieved with each pass of a device during the thrombectomy procedure. Second, the per-pass composition was compared with procedural and clinical data including angiographic outcome and stroke etiology. Read More

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.023419
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http://dx.doi.org/10.1161/STROKEAHA.118.023419DOI Listing
May 2019
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Targeting Peroxisome Proliferator-Activated Receptor-Gamma Decreases Host Mortality After Influenza Infection in Obese Mice.

Viral Immunol 2019 Apr 19. Epub 2019 Apr 19.

1 Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.

Obesity is an independent risk factor for severe influenza infection. However, the underlying cellular and molecular mechanisms are still incompletely understood. In this study, we have utilized a murine influenza infection model in genetic-induced obese (db/db) mice to explore the mechanisms by which obesity increases host susceptibility to influenza infection. Read More

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https://www.liebertpub.com/doi/10.1089/vim.2019.0016
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http://dx.doi.org/10.1089/vim.2019.0016DOI Listing
April 2019
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A Comparative Analysis of the Safety Profile of Direct Oral Anticoagulants Using the FDA Adverse Event Reporting System.

Eur J Haematol 2019 Apr 22. Epub 2019 Apr 22.

Division of Hematology, Oregon Health & Science University, Portland, OR.

Introductio: Direct oral anticoagulants (DOACs) are being increasingly used. However, unlike warfarin, less is known regarding their long-term side effects. To better evaluate the rates of DOAC-related adverse events (AEs) on a population level we examined AEs reported to the FDA for three commonly used DOACs and warfarin. Read More

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http://doi.wiley.com/10.1111/ejh.13240
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http://dx.doi.org/10.1111/ejh.13240DOI Listing
April 2019
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