379,003 results match your criteria Maternal and child health journal[Journal]


β-Elemene Inhibits Human Sperm Function by Affecting Sperm Vitality and Intracellular Calcium.

Cell Physiol Biochem 2018 Dec 6;51(5):2019-2029. Epub 2018 Dec 6.

State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou,

Background/aims: β-Elemene is a bioactive sesquiterpene compound that exhibits a potent anti-tumor effect and is used in various clinical applications. However, little is known about its effect on the male reproductive system. The objective of this study was to investigate the in vitro actions of β-elemene on human sperm function and elucidate the underlying mechanism. Read More

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December 2018
3 Reads

Down-Regulation of Laminin (LN)- α5 is Associated with Preeclampsia and Impairs Trophoblast Cell Viability and Invasiveness Through PI3K Signaling Pathway.

Cell Physiol Biochem 2018 Dec 6;51(5):2030-2040. Epub 2018 Dec 6.

Department of Obstetrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing,

Background/aims: Preeclampsia (PE) is a gestational disorder defined as hypertension and proteinuria, which is deemed a major cause of maternal and neonatal mortality and morbidity worldwide. The aim of this study was to investigate the expression patterns of placental laminin (LN)-α5 expression in normal and PE pregnancies, as well as evaluating the effects of LN-α5 on trophoblast proliferation, apoptosis, and invasion.

Methods: LN-α5 expression levels were examined by reverse-transcriptase polymerase chain reaction (RT-PCR), and further confirmed by western blotting and immunofluorescence staining. Read More

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December 2018
2 Reads

Mothers' feelings about infants' negative emotions and mother-infant interactions among the Gamo of Southern Ethiopia.

Infant Behav Dev 2018 Dec 3;54:22-36. Epub 2018 Dec 3.

University of Tennessee, Department of Child and Family Studies, 1215 W. Cumberland Ave Knoxville, TN 37996, USA. Electronic address:

Parents' exposure to stressful ecosocial situations, like inadequate resources, is linked to parents' perceptions of infants' fussing and crying and less sensitive caregiving. However, studies supporting these findings predominantly come from Western contexts of parenting and infant care. Ecosocial situations may have different effects on parenting and infants in distinct cultural contexts. Read More

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December 2018
1 Read

Does exclusive breastfeeding relate to the longer duration of breastfeeding? A prospective cohort study.

Midwifery 2018 Nov 19;69:163-171. Epub 2018 Nov 19.

Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA. Electronic address:

Objectives: Suboptimal breastfeeding contributes to morbidity and mortality in children. Studies in high-income countries (HICs) show that exclusive-breastfeeding (EBF) is associated with longer breastfeeding duration. The aim of this study was to determine whether maternal reports of EBF at six months are associated with longer duration of breastfeeding during the first two years of life in a low and middle-income country (LMIC) setting, and to identify determinants of breastfeeding duration. Read More

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November 2018

Maternal and paternal origin differentially affect prosocial behavior and neural mechanisms in prairie voles.

Behav Brain Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Biology and Integrated Bioscience Program, The University of Akron, Akron, OH, 44325, United States; Department of Biological Sciences, University of Texas at El Paso, El Paso, 79968, United States.

This study tested the hypotheses that maternal and paternal effects differentially influence expression of their offspring's adult behavior and underlying neural mechanisms. We predicted that maternal influences would be greater than paternal influences on male offspring. We tested these hypotheses by cross-breeding two phenotypically-, behaviorally- and neuroanatomically-distinct populations of prairie voles (Microtus ochrogaster) from Illinois, which are highly prosocial, and Kansas, which are significantly less prosocial. Read More

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December 2018
2 Reads

Metabolome-wide association study of anti-epileptic drug treatment during pregnancy.

Toxicol Appl Pharmacol 2018 Dec 3. Epub 2018 Dec 3.

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States. Electronic address:

Pregnant women with epilepsy (PWWE) require continuous anti-epileptic drug (AED) treatment to avoid risk to themselves and fetal risks secondary to maternal seizures, resulting in prolonged AED exposure to the developing embryo and fetus. The objectives of this study were to determine whether high-resolution metabolomics is able to link the metabolite profile of PWWE receiving lamotrigine or levetiracetam for seizure control to associated pharmacodynamic (PD) biological responses. Untargeted metabolomic analysis of plasma obtained from 82 PWWE was completed using high-resolution mass spectrometry. Read More

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December 2018
4 Reads

Massive cytoplasmic transport and microtubule organization in fertilized chordate eggs.

Dev Biol 2018 Dec 3. Epub 2018 Dec 3.

Research Institute for Electronic Science, Hokkaido University, Sapporo, Hokkaido 001-0020, Japan.

Eggs have developed their own strategies for early development. Amphibian, teleost fish, and ascidian eggs show cortical rotation and an accompanying structure, a cortical parallel microtubule (MT) array, during the one-cell embryonic stage. Cortical rotation is thought to relocate maternal deposits to a certain compartment of the egg and to polarize the embryo. Read More

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December 2018
3 Reads

Does Maternal Age at Retrieval Influence the Implantation Potential of Euploid Blastocysts?

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY 10021.

Background: Age-related decline in reproductive potential is mainly due to the increased incidence of aneuploidy. Furthermore, two recent studies have shown that euploid embryos of older women may have a lower implantation potential compared to those of younger women, suggesting that aging might compromise embryos beyond their ploidy status. However, the inherent limitations of these studies preclude solid conclusions. Read More

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December 2018
3 Reads

Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols.

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston, Houston, Texas.

Background: Inositols (INOs) supplementation during pregnancy, specifically the combination of myo-inositol (MI) and D-chiro-inositol (DCI), has been reported to improve vascular parameters in women with gestational diabetes mellitus. We demonstrated previously that offspring born to pregnant mice lacking endothelial nitric oxide synthase (eNOS+/-) gene have hypertension (HTN) as adults and when fed high fat diet (HFD) develop a metabolic syndrome (MS) phenotype.

Objective: Our aim was to evaluate if INOs treatment in pregnancy complicated by MS improves the vascular and metabolic profile in mice offspring programmed in utero to develop HTN and MS. Read More

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December 2018

Geospatial Analysis of Birth Records to Target Programming for Mothers With Gestational Diabetes Mellitus in Michigan, 2013.

Public Health Rep 2018 Dec 6:33354918815183. Epub 2018 Dec 6.

2 Health Data Research, Analysis and Mapping Center at Western Michigan University, Kalamazoo, MI, USA.

Objectives:: The incidence of gestational diabetes mellitus (GDM) in the United States has increased during the past several decades. The objective of this study was to use birth records and a combination of statistical and geographic information system (GIS) analyses to evaluate GDM rates among subgroups of pregnant women in Michigan.

Materials And Methods:: We obtained data on maternal demographic and health-related characteristics and regions of residence from 2013 Michigan birth records. Read More

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December 2018
1 Read

Maternal and perinatal outcomes of expectant treatment of severe preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):379-386. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Ginecología y Obstetricia No. 3 “Dr. Víctor Manuel Espinoza de los Reyes Sánchez”, Unidad de Cuidados Intensivos. Ciudad de México, México

Background: In severe preeclampsia (SP), pregnancy interruption is the first recommendation. However, some patients receive expectant treatment.

Objetive: To determine maternal and perinatal results of expectant treatment of SP in the intensive care unit (ICU) of a high-specialty hospital. Read More

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November 2018
6 Reads

Application of the Andersen-Newman model of health care utilization to understand antenatal care use in Kersa District, Eastern Ethiopia.

PLoS One 2018 6;13(12):e0208729. Epub 2018 Dec 6.

Research Centre for Generational Health and Ageing, Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW, Australia.

Background: In Ethiopia, the uptake of antenatal care services has been low. Moreover, there is less frequent and late attendance of antenatal care among women who attend. Using the Anderson-Newman model of health care utilization, this study identified factors that either facilitate or impede antenatal care utilization in Kersa district, Eastern Ethiopia. Read More

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December 2018
1 Read

Prevalence of functional constipation among Palestinian preschool children and the relation to stressful life events.

PLoS One 2018 6;13(12):e0208571. Epub 2018 Dec 6.

Haaglanden Medical Center, The Hague, the Netherlands.

Aim: Increasing evidence exists with respect to the relation between stressful life events and functional constipation (FC). We aimed to investigate the prevalence of FC in Palestinian refugee preschool children and to determine if stress and trauma exposure are risk factors of FC in these children.

Methods: From November 2013 until May 2014, a cross-sectional survey was conducted in West Bank, Gaza and Jordan. Read More

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December 2018

A novel approach to stabilize fetal cell-free DNA fraction in maternal blood samples for extended period of time.

PLoS One 2018 6;13(12):e0208508. Epub 2018 Dec 6.

Department of Research and Development, CFGenome Omaha NE, United States of America.

This study was undertaken to evaluate a novel method for stabilizing and preserving the original proportion of cell-free fetal DNA (cffDNA) in maternal blood for extended periods of time without using crosslinking agents, such as formaldehyde, which compromise DNA integrity and extraction efficiency. Blood was drawn from pregnant donors into K3EDTA and Blood Exo DNA ProTeck® (ProTeck) tubes. Blood drawn into both tubes were aliquoted and stored at three different temperatures. Read More

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December 2018

A comparison of maternal and newborn health services costs in Sindh Pakistan.

PLoS One 2018 6;13(12):e0208299. Epub 2018 Dec 6.

Division of Women & Child Health, Aga Khan University, Karachi, Pakistan.

Pakistani women suffer the highest rate of maternal mortality in South Asia. A lack of comprehensive knowledge about maternal and newborn health (MNH) services costs impedes policy decisions to maximize the benefit from existing, as well as emerging, MNH interventions in Pakistan. We compared MNH service costs at different levels of care. Read More

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December 2018
2 Reads

The multiple maternal legacy of the Late Iron Age group of Urville-Nacqueville (France, Normandy) documents a long-standing genetic contact zone in northwestern France.

PLoS One 2018 6;13(12):e0207459. Epub 2018 Dec 6.

De la Préhistoire à l'Actuel, Culture, Environnement, Anthropologie-UMR 5199, CNRS, Université de Bordeaux, Allée Geoffroy Saint-Hilaire, CS, Pessac Cedex, France.

The compilation of archaeological and genetic data for ancient European human groups has provided persuasive evidence for a complex series of migrations, population replacements and admixture until the Bronze Age. If the Bronze-to-Iron Age transition has been well documented archaeologically, ancient DNA (aDNA) remains rare for the latter period and does not precisely reflect the genetic diversity of European Celtic groups. In order to document the evolution of European communities, we analysed 45 individuals from the Late Iron Age (La Tène) Urville-Nacqueville necropolis in northwestern France, a region recognized as a major cultural contact zone between groups from both sides of the Channel. Read More

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December 2018
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Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study.

PLoS One 2018 6;13(12):e0208137. Epub 2018 Dec 6.

Farr Institute of Health Informatics, University College London, London, United Kingdom.

Background: Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population. Read More

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December 2018
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My Womban's Life: Understanding Human Endometrial Function.

Authors:
Lois Salamonsen

Reproduction 2018 Dec 1. Epub 2018 Dec 1.

L Salamonsen, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Australia.

The focus of my life in science, has been to improve reproductive health for women, with an emphasis on the endometrium, the most dynamic tissue in the human body: its remarkable cyclical remodelling is essential for establishment of pregnancy. The most notable events in a woman's endometrial cycle are menstruation and endometrial repair, regeneration of the endometrium during the proliferative phase, attainment of receptivity by the mid-secretory phase of the cycle and the embryo-maternal interactions that initiate peri-implantation events within the microenvironment of the uterine cavity. I have contributed to understanding the molecular and cellular changes underpinning these events, and how disturbance of them leads to menstrual disorders, infertility and endometrial diseases including abnormal uterine bleeding, endometriosis and endometrial cancer. Read More

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December 2018

Evidence for functional interactions between the placenta and brain in pregnant mice.

FASEB J 2018 Dec 6:fj201802037R. Epub 2018 Dec 6.

Division of Animal Sciences, University of Missouri, Columbia, Missouri, USA.

The placenta plays a pivotal role in the development of the fetal brain and also influences maternal brain function, but our understanding of communication between the placenta and brain remains limited. Using a gene expression and network analysis approach, we provide evidence that the placenta transcriptome is tightly interconnected with the maternal brain and fetal brain in d 15 pregnant C57BL/6J mice. Activation of serotonergic synapse signaling and inhibition of neurotrophin signaling were identified as potential mediators of crosstalk between the placenta and maternal brain and fetal brain, respectively. Read More

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December 2018
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microRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex.

FASEB J 2018 Dec 6:fj201801094RR. Epub 2018 Dec 6.

Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.

Choline availability modulates neurogenesis and cerebral cortex development through the regulation of neural progenitor cell (NPC) proliferative and differentiation capacity. In this study, we demonstrated that cortical NPC self-renewal is controlled by choline via the expression of a microRNA (miR-129-5p), whose role in the developing brain has not been examined, and which, in turn, inhibits synthesis of the epidermal growth factor receptor (EGFR) protein. Specifically, we found that low choline (LC) availability led to the upregulation of miR-129-5p expression in cortical NPCs in vitro and in vivo, causing the downregulation of EGFR and thereby disrupting NPC self-renewal and cortical neurogenesis. Read More

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December 2018

DHA supplementation during prenatal ethanol exposure alters the expression of fetal rat liver genes involved in oxidative stress regulation.

Appl Physiol Nutr Metab 2018 Dec 6. Epub 2018 Dec 6.

University of Manitoba, Food and Human Nutritional Sciences, Winnipeg, Manitoba, Canada.

Prenatal ethanol (EtOH) exposure is known to induce adverse effects on fetal brain development. Docosahexaenoic acid (DHA) has been shown to alleviate these effects by upregulating antioxidant mechanisms in the brain. The liver is the first organ to receive enriched blood after placental transport; therefore, it could be negatively affected by EtOH, but no studies have assessed the effects of DHA on fetal liver. Read More

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December 2018

Exposure to gestational diabetes is a stronger predictor of dysmetabolic traits in children than size at birth.

J Clin Endocrinol Metab 2018 Dec 5. Epub 2018 Dec 5.

Department of Endocrinology, Diabetes and Bone-metabolic Research Unit, Rigshospitalet, Copenhagen Denmark.

Context And Objective: Being born small or large for gestational age and intrauterine exposure to gestational diabetes (GDM) increase the risk of type 2 diabetes (T2D) in the offspring, however, the potential combined deleterious effects of size at birth and GDM exposure remains unknown. We aimed to examine the independent effect of size at birth as well as the influence of GDM exposure in utero on cardio-metabolic traits, body composition, and puberty status in children.

Design, Participants And Methods: This study is a longitudinal birth cohort study. Read More

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December 2018

Pediatric Office Delivery of Smoking Cessation Assistance for Breast-Feeding Mothers.

Nicotine Tob Res 2018 Dec 6. Epub 2018 Dec 6.

Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA.

Introduction: National and international organizations have done an excellent job of advocating and promoting breast feeding for all mothers. This study assessed to what extent an intervention increased delivery of cessation assistance to breast-feeding mothers who smoke.

Methods: Data were collected between April and October 2015 in five US states as part of a cluster randomized controlled trial in 10 pediatric practices. Read More

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December 2018
2 Reads

Short communication: rapid quantitation of flecainide in human plasma for therapeutic drug monitoring using liquid chromatography and time-of-flight mass-spectrometry.

Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.

Analytical Services International (ASI), St George's-University of London, Cranmer Terrace, London SW17 0RE, UK.

Background: Measurement of flecainide is useful to optimize dosage and minimize risks of toxicity. Further, there is a need for urgent sample analysis when flecainide is used in transplacental therapy for fetal tachycardia. To this end, we have developed and validated a rapid assay for the measurement of flecainide in human plasma or serum, using a small sample volume (50 µL). Read More

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December 2018

Emergent surgical treatment of lethal valve dysfunction during pregnancy in a last-trimester patient.

Saudi Med J 2018 Dec;39(12):1249-1252

Department of Cardiovascular Surgery, Selcuk University, Konya, Turkey. E-mail.

A mechanical heart valve thrombosis during pregnancy is one of the most lethal conditions to experience due to its detrimental effects on both mother and fetus. Cardiac surgery during pregnancy is reserved for cases where medical treatment fails due to harmful maternal and fetal effects. A 24-year-old female in the 38th week of pregnancy was admitted to the emergency room with aggravated dyspnea, tachypnea, and palpitations. Read More

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December 2018

In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra.

J Biomed Opt 2018 Dec;23(12):1-6

California Institute of Technology, Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Depa, United States.

Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subjective and detect only late events, such as cervical effacement and dilation. Here, we present a photoacoustic endoscope that can quantify tissue hydration by measuring near-infrared cervical spectra. Read More

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December 2018
8 Reads
2.859 Impact Factor

A core outcome set for the evaluation of treatments for twin-twin transfusion syndrome.

Ultrasound Obstet Gynecol 2018 Dec 6. Epub 2018 Dec 6.

Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.

Background: A minimum data set, known as a core outcome set, should standardise outcome selection, collection, and reporting across future twin-to-twin transfusion syndrome research.

Methods: An international steering group including healthcare professionals, researchers, and patients, guided the development of this core outcome set. Potential core outcomes, identified through a comprehensive literature review, were entered into a three round Delphi survey. Read More

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December 2018
1 Read

Deep integrative analysis of microRNA-mRNA regulatory networks for biomarker and target discovery in chondrosarcoma.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Joint Surgery, The Affiliated Hospital of Jining Medical University, Shandong, China.

Chondrosarcoma (CHS) is a common malignant bone sarcoma and its occurrence increases with age. microRNAs (miRNAs) are a class of noncoding RNAs that participate in various biological processes and disease pathogenesis by targeting functional messenger RNA (mRNA). However, the modulation of miRNAs in CHS remains largely unknown. Read More

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December 2018
1 Read

miR-202 modulates the progression of neuropathic pain through targeting RAP1A.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Anestheiology, Liaocheng People's Hospital, Liaocheng, Shandong, China.

Neuropathic pain is a somatosensory disorder which is caused by disease or nerve injury that affects the nervous system. microRNAs (miRNAs) are proved to play crucial roles in the development of neuropathic pain. However, the role of miR-202 in neuropathic pain is still unknown. Read More

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December 2018
3 Reads

ATTACHMENT AND MEMORY RESEARCH: REFLECTING ON A SHARED PAST AND A COLLABORATIVE FUTURE.

Authors:
Elaine Reese

Monogr Soc Res Child Dev 2018 Dec;83(4):162-172

This commentary applauds the authors of the monograph, The Mother-Child Attachment Partnership in Early Childhood: Secure Base Behavioral and Representational Processes, for their thorough and elegant exploration of the development of attachment working models in the preschool years in relation to maternal sensitivity and attachment representations, mother-child co-constructions of attachment-relevant stories, and children's own secure base behavior. These findings are set against a backdrop of children's memory development, with the recommendation that future research delves even younger to explore the development of attachment working models in children under 3 years. A second recommendation is to continue the work with older children, with a particular focus on the conversations they are having with caregivers about actual attachment-related experiences. Read More

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December 2018

IV. CO-CONSTRUCTION OF ATTACHMENT REPRESENTATIONS AND AFFECT-REGULATING COGNITIONS: THE ROLE OF MATERNAL ATTACHMENT SECURITY.

Monogr Soc Res Child Dev 2018 Dec;83(4):60-73

This study focused on the role of maternal co-construction skills in building attachment relevant representations in early childhood. Thirty-four mothers and their 4- to 5-year-old children were presented with two co-construction tasks, one an attachment storytelling task, the other an affect discussion task about emotion-laden situations. Maternal co-construction skills were assessed with several scales that scored the quality of the co-construction partnership, the mother's skill in prompting elaboration, and helping build an explanatory framework. Read More

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December 2018

II. MEASURES: SECURE BASE BEHAVIOR, CO-CONSTRUCTION, AND ATTACHMENT SCRIPTS.

Monogr Soc Res Child Dev 2018 Dec;83(4):22-34

In order to examine the interplay between behavioral and cognitive representations of attachment during early childhood, we compiled both behavior-based and more cognitive-based attachment measures for this age range. The behavior-based measures were observational Q-set methodologies already established in the literature. Measures of attachment representations for the children and mothers were narrative-based procedures, that is, established storytelling tasks for obtaining attachment narratives from children and adults. Read More

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December 2018
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V. MATERNAL SENSITIVITY AND CO-CONSTRUCTION SKILLS: CONCURRENT AND LONGITUDINAL ASSOCIATIONS WITH PRESCHOOLERS' SECURE BASE BEHAVIOR.

Monogr Soc Res Child Dev 2018 Dec;83(4):74-90

This study investigated the associations among maternal sensitivity, maternal secure base script co-construction skills, and children's secure base behavior during early childhood. Maternal sensitivity and children's secure base behavior were assessed in naturalistic settings among 81 mother-child dyads when the children were approximately 3.5 years old. Read More

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December 2018

VI. INTERGENERATIONAL TRANSMISSION OF SECURE BASE SCRIPT KNOWLEDGE: THE ROLE OF MATERNAL CO-CONSTRUCTION SKILLS.

Monogr Soc Res Child Dev 2018 Dec;83(4):91-105

This study examined the link between mothers' and children's script-like representations of attachment and the role of maternal co-construction skills in facilitating script knowledge in their children. Fifty-nine children recruited from preschools in Bucharest, Romania (age range 4 to 5 years) completed a shortened version of the Attachment Story Completion Task (ASCT) to assess their secure base script knowledge whereas their mother's script knowledge was assessed with the Attachment Script Assessment (ASA). In addition, the mother-child pairs completed the Affect Discussion Task (see Chapter II) to assess mothers' co-construction skills. Read More

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December 2018

VII. MATERNAL SECURE BASE SCRIPT KNOWLEDGE AND JUDGMENTS OF MOTHER-CHILD INTERACTIONS.

Monogr Soc Res Child Dev 2018 Dec;83(4):106-120

Previous studies have shown that mothers with high script scores are better at providing secure base support in naturalistic settings. In the current study, we examine whether maternal script knowledge guides mothers' expectations and judgments of mother-child interactions, providing a bridge between their knowledge and behavior. Forty mothers were asked to use a new Parental Secure Base Q-set designed to characterize a typical mother-child play day at a park. Read More

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December 2018
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III. THE ORGANIZATION OF ATTACHMENT BEHAVIOR IN EARLY CHILDHOOD: LINKS WITH MATERNAL SENSITIVITY AND CHILD ATTACHMENT REPRESENTATIONS.

Monogr Soc Res Child Dev 2018 Dec;83(4):35-59

This article investigated two central questions about mother-child attachment relationships during early childhood: (1) the association between maternal sensitivity and child attachment behavior (Study 1) and (2) the link between child attachment behavior and representations (Study 2). In Study 1, maternal sensitivity and child security were assessed in naturalistic contexts among 74 middle-class dyads, when children were about 3.5 and again 5. Read More

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December 2018

Advanced Paternal Age, Infertility, and Reproductive Risks: A Review of the Literature.

Prenat Diagn 2018 Dec 5. Epub 2018 Dec 5.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine, Rutgers/Robert Wood Johnson Medical School, New Brunswick, NJ.

Advanced paternal age (APA) is associated with infertility and other reproductive risks. Studies looking at APA and outcomes have used different paternal age cut-offs, which has complicated systematic evaluations of reproductive risk associated with paternal aging. This review of the literature suggests that the impact of paternal aging on adverse reproductive outcomes is small, but significant. Read More

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December 2018

Frequent blood donation and offspring birth weight-a next-generation association?

Transfusion 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.

Background: The prevalence of iron depletion is high among premenopausal women who donate blood frequently. Studies in nondonor populations indicate that iron deficiency anemia is associated with an increased risk of low birth weight. This prompts concerns that iron deficiency induced by frequent blood donation might impair subsequent fetal development. Read More

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December 2018
3 Reads

Transition to parenthood and mental health at 30 years: a prospective comparison of mothers and fathers in a large Brazilian birth cohort.

Arch Womens Ment Health 2018 Dec 6. Epub 2018 Dec 6.

Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.

Parenthood represents a major biological, social and environmental life change. Mental health disorders are common in parents and impact both the parent and their offspring. However, the relationship between parenthood and mental health and the direction of these effects are poorly understood. Read More

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December 2018
1 Read

Development of an innovative one-step nested PCR strategy for virus detection using the LNA technique.

Sci China Life Sci 2018 Dec 3. Epub 2018 Dec 3.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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December 2018
2 Reads

Acupuncture Regulates the Balance of CD4 T Cell Subtypes in Experimental Asthma Mice.

Chin J Integr Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Objective: To evaluate the involvement of different CD4 T cell subtypes in the anti-asthmatic effects of acupuncture in asthmatic mice.

Methods: BALB/c mice were challenged by ovalbumin (OVA) for the establishment of experimental asthma model. Mice were divided into 4 groups by a random number table including the normal control, asthma model, acupuncture and sham acupuncture groups (14 per group). Read More

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December 2018
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Effect of metoclopramide administration to mothers on neonatal bilirubin and maternal prolactin: a randomized, controlled, clinical trial.

World J Pediatr 2018 Dec 5. Epub 2018 Dec 5.

Department of Midwifery, Students Research Committee, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Jaundice is a common neonatal problem. This study was conducted to determine the effect of metoclopramide on neonatal bilirubin and maternal prolactin (primary outcomes) and milk volume (secondary outcome).

Methods: This triple-blind, randomized, controlled, clinical trial was conducted on 112 mothers. Read More

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December 2018

False-positive rates in screening for trisomies 18 and 13: a comparison between first-trimester combined screening and a cfDNA-based approach.

Arch Gynecol Obstet 2018 Dec 5. Epub 2018 Dec 5.

Department of Women's Health, University Women's Hospital Tuebingen, Calwerstrasse 7, 72076, Tübingen, Germany.

Purpose: To determine the false-positive rates (FPR) associated with screening for trisomy 18/13 using first-trimester combined screening (FTCS) and an ultrasound plus cfDNA-based approach (US-cfDNA), which includes a detailed ultrasound examination, a cfDNA analysis and a FTCS reflex backup test for cases with uninformative results.

Methods: This is a sub-analysis of a randomized controlled trial, which was performed between 2015 and 2016. Pregnant women with a normal first-trimester ultrasound examination at 11-13 weeks' gestation (NT < 3. Read More

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December 2018

Profound bilateral post-partum retinal circulation ischemia in two diabetic mothers with pre-eclampsia.

Am J Ophthalmol Case Rep 2019 Mar 10;13:28-31. Epub 2018 Nov 10.

Howard University, 2041 Georgia Avenue NW, Washington DC, USA.

Purpose: We report 2 cases of young diabetic mothers with pre-eclampsia and no previously documented visual deficits prior to pregnancy who were found to have profound retinal circulation loss during the postpartum period.

Observations: Fluorescein angiogram in both cases documented profound ischemia of retinal and macular circulation with resulting severe vision loss, leading to legal blindness.

Conclusions And Importance: While Pre-eclampsia and Eclampsia are well known clinical entities with potentially grave effects on both the mother and child, there is little information about the possible combined effects of diabetes and Pre-eclampsia/Eclampsia on the retinal circulation. Read More

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Maternal age effects on fecundity and offspring egg-to-adult viability are not affected by mitochondrial haplotype.

Ecol Evol 2018 Nov 18;8(22):10722-10732. Epub 2018 Oct 18.

School of Biological Sciences Monash University Clayton Victoria Australia.

While numerous studies have demonstrated that mitochondrial genetic variation can shape organismal phenotype, the level of contribution the mitochondrial genotype makes to life-history phenotype across the life course remains unknown. Furthermore, a clear technical bias has emerged in studies of mitochondrial effects on reproduction, with many studies conducted on males, but few on females. Here, we apply a classic prediction of the evolutionary theory of aging to the mitochondrial genome, predicting the declining force of natural selection with age will have facilitated the accumulation of mtDNA mutations that confer late-life effects on female reproductive performance. Read More

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November 2018

Maternal mRNA input of growth and stress-response-related genes in cichlids in relation to egg size and trophic specialization.

Evodevo 2018 1;9:23. Epub 2018 Dec 1.

1Institute of Biology, University of Graz, Universitätsplatz 2, 8010 Graz, Austria.

Background: Egg size represents an important form of maternal effect determined by a complex interplay of long-term adaptation and short-term plasticity balancing egg size with brood size. Haplochromine cichlids are maternal mouthbrooders showing differential parental investment in different species, manifested in great variation in egg size, brood size and duration of maternal care. Little is known about maternally determined molecular characters of eggs in fishes and their relation to egg size and trophic specialization. Read More

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December 2018

Environmental Enrichment Attenuates Morphine-Induced Conditioned Place Preference and Locomotor Sensitization in Maternally Separated Rat Pups.

Basic Clin Neurosci 2018 Jul-Aug;9(4):241-250. Epub 2018 Jul 1.

Laboratory of Animal Addiction Models, Physiology Research Center, Semnan University of Medical Sciences, Semnan, Iran.

Introduction: This study investigated the effect of the environmental enrichment during adolescence on morphine-induced Conditioned Place Preference (CPP) and locomotor sensitization in maternally separated male and female rat pups.

Methods: Male Wistar rats were allowed to mate with female virgin Wistar rats. Pups were separated from them 3 hours per day during 2-14 days postnatal. Read More

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Chromosomal abnormalities and copy number variations in fetal ventricular septal defects.

Mol Cytogenet 2018 28;11:58. Epub 2018 Nov 28.

Department of the Prenatal Diagnosis Center, Fujian Provincial Maternity and Children's Hospital, affiliated hospital of Fujian Medical University, Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect, Fuzhou, China.

Background: This study aimed to evaluate the applicability of chromosomal microarray analysis (CMA), rather than traditional chromosome analysis, in prenatal diagnosis of ventricular septal defects (VSDs) for superior prenatal genetic counseling and to reveal a potential correlation between submicroscopic chromosomal aberrations and VSDs.

Results: Among the 151 VSD cases, 79 (52.3%) had isolated defects and 72 (47. Read More

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November 2018
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