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    1741 results match your criteria Materials for Wound Closure

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    Polyurethane-silica hybrid foams from a one-step foaming reaction, coupled with a sol-gel process, for enhanced wound healing.
    Mater Sci Eng C Mater Biol Appl 2017 Oct 12;79:866-874. Epub 2017 May 12.
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, 637457, Singapore. Electronic address:
    Polyurethane (PU)-based dressing foams have been widely used due to their excellent water absorption capability, optimal mechanical properties, and unequaled economic advantage. However, the low bioactivity and poor healing capability of PU limit the applications of PU dressings in complex wound healing cases. To resolve this problem, this study was carried out the hybridization of bioactive silica nanoparticles with PU through a one-step foaming reaction that is coupled with the sol-gel process. Read More

    Application of static fatigue testing to the behavior of absorbable sutures.
    J Mech Behav Biomed Mater 2017 Jun 10;74:232-235. Epub 2017 Jun 10.
    Department of Materials Science and Engineering, Rutgers, The State University of New Jersey, 607 Taylor Road, Piscataway, NJ 08854-8065, USA. Electronic address:
    Absorbable sutures, since their conception, have become the dominant method for surgical wound closure and are constantly being improved. However, despite their years of service, not all aspects of their performance are fully understood. In particular, suture absorption is usually characterized by immersing the suture in a model in vitro environment under zero stress followed by measurement of the residual tensile strength as a function of immersion time. Read More

    Adipose-derived stem cells seeded in Pluronic F-127 hydrogel promotes diabetic wound healing.
    J Surg Res 2017 May 5. Epub 2017 May 5.
    Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China. Electronic address:
    Background: Chronic nonhealing wound is a multifactorial complication of diabetes that results specifically as a consequence of impaired angiogenesis and currently lacks in effective treatments. Although a stem cell-based therapy may provide a novel treatment to augment diabetic wound healing, inferior cell survival at the diabetic skin wound is one of the key causes that are responsible for the low efficacy of the stem cell therapy.

    Materials And Methods: In this work, we used an injectable, biocompatible, and thermosensitive hydrogel Pluronic F-127 to encapsulate allogeneic nondiabetic adipose-derived stem cells (ADSCs) and topically applied the cells to a full-thickness cutaneous wound in the streptozotocin-induced diabetic model in rats. Read More

    A Prospective, Randomized, Single-Blind Study Comparing Cyanoacrylate Adhesives to Sutures for Wound Closure in Skin Cancer Patients.
    Dermatol Surg 2017 Jun 6. Epub 2017 Jun 6.
    *Tufts University School of Medicine, Boston, Massachusetts;†Massachusetts Dermatology Associates, Beverly, Massachusetts;‡Beverly Hospital, Beverly, Massachusetts.
    Background: Cyanoacrylate tissue adhesives are not more likely to result in wound dehiscence or infection than sutured closures. However, suturing is the gold standard for optimal cosmetic appearance of scars.

    Objective: To determine whether cyanoacrylate tissue adhesives produce a cosmetic outcome equivalent to sutures at 3 months. Read More

    Induction of immune gene expression and inflammatory mediator release by commonly used surgical suture materials: an experimental in vitro study.
    Patient Saf Surg 2017 31;11:16. Epub 2017 May 31.
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, 1142 New Zealand.
    Background: Surgeons have a range of materials to choose from to complete wound closure, yet surprisingly very little is still known about the body's immune response to the suture materials in current use. The growing literature of adverse suture material reactions provided the objective of this study, to use in vitro assays to quantify levels of inflammation produced by seven commonly used suture materials in surgical procedures.

    Methods: Human monocyte/macrophage THP-1 cells were exposed to suture materials for 1, 3 and 5 days. Read More

    Bio-inspired crosslinking and matrix-drug interactions for advanced wound dressings with long-term antimicrobial activity.
    Biomaterials 2017 Sep 26;138:153-168. Epub 2017 May 26.
    Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore, 169856, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore, 169857, Singapore. Electronic address:
    There is a growing demand for durable advanced wound dressings for the management of persistent infections after deep burn injuries. Herein, we demonstrated the preparation of durable antimicrobial nanofiber mats, by taking advantage of strong interfacial interactions between polyhydroxy antibiotics (with varying number of OH groups) and gelatin and their in-situ crosslinking with polydopamine (pDA) using ammonium carbonate diffusion method. Polydopamine crosslinking did not interfere with the antimicrobial efficacy of the loaded antibiotics. Read More

    Low concentrations of neutrophil extracellular traps induce proliferation in human keratinocytes via NF-kB activation.
    J Dermatol Sci 2017 May 23. Epub 2017 May 23.
    Innovative Research Laboratory for Wound Healing, Health Sciences Department, Università del Piemonte Orientale "A. Avogadro", via Solaroli, 17, 28100 Novara, Italy. Electronic address:
    Introduction: Granulocytes play a pivotal role in innate immune response, as pathogen invasion activates neutrophils, a subclass of granulocytes, inducing the production of neutrophil extracellular traps (NETs). In this study, it has been evaluated how NETs could affect human keratinocytes (HaCaT cells) behaviour.

    Materials And Methods: HaCaT cells were treated with increasing NETs concentrations (0. Read More

    The Comparative Effectiveness of a Human Fibroblast Dermal Substitute versus a Dehydrated Human Amnion/Chorion Membrane Allograft for the Treatment of Diabetic Foot Ulcers in a Real-world Setting.
    Wounds 2017 May;29(5):125-132
    Background: Impaired wound healing is associated with serious complications in patients with diabetes. Diabetic foot ulcers (DFUs) can lead to costly complications and an increased mortality rate. Standard treatments for DFUs often need to be augmented with adjunctive therapies designed to stimulate healing in recalcitrant wounds. Read More

    Effect of Negative Pressure Wound Therapy With Instillation on Bioburden in Chronically Infected Wounds.
    Wounds 2017 May 25. Epub 2017 May 25.
    Mt Sinai St Luke's - West Hospitals, New York, NY.
    Introduction: Standard negative pressure wound therapy (NPWT) has been shown to help close wounds despite increasing planktonic bioburden. Both planktonic and biofilm critical colonization are associated with delayed wound healing; therefore, reducing microbial colonization is thought to aid wound healing. The use of NPWT with topical antimicrobial irrigation solution has previously shown reduction in quantitative planktonic bioburden when combined with sharp debridement in chronic wounds. Read More

    Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice.
    Biomater Sci 2017 May 31. Epub 2017 May 31.
    Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, 06800, Turkey. and Neuroscience Graduate Program, Bilkent University, Ankara, 06800, Turkey.
    There is an urgent need for more efficient treatment of chronic wounds in diabetic patients especially with a high risk of leg amputation. Biomaterials capable of presenting extracellular matrix-mimetic signals may assist in the recovery of diabetic wounds by creating a more conducive environment for blood vessel formation and modulating the immune system. In a previous study, we showed that glycosaminoglycan-mimetic peptide nanofibers are able to increase the rate of closure in STZ-induced diabetic rats by induction of angiogenesis. Read More

    Biological Implant for Complex Abdominal Wall Reconstruction: A Single Institution Experience and Review of Literature.
    World J Surg 2017 May 30. Epub 2017 May 30.
    Barts Health NHS Trust, London, UK.
    Aim: To present our single institution and surgeon's complex abdominal wall reconstructions (CAWR) experience with Permacol™ mesh through a non-randomized study.

    Patients And Method: Data of 51 consecutive patients were prospectively collected between 2003 and 2015. Patients had a median of 3 comorbidities (range 0-10) and 68% were Center for Disease Control class II-IV. Read More

    Report of a jaw osteonecrosis possibly caused
by denosumab.
    Eur J Oral Implantol 2017 ;10(2):213-222
    Purpose: To report a case of osteonecrosis of the jaw (ONJ) occurring in an implant area possibly related to denosumab, a relatively new antiosteoporotic agent.

    Materials And Methods: Two months following the extraction of both maxillary first molars, a bilateral maxillary sinus floor elevation was performed on a 64-year-old female patient under a biannual 
60 mg denosumab antiosteoporotic treatment. Seven months later, two implants were inserted in a single-stage procedure in each of the grafted sinuses. Read More

    Role of Local Infiltration of Tranexamic Acid in Reducing Blood Loss in Peritrochanteric Fracture Surgery in the Elderly Population.
    Malays Orthop J 2016 Nov;10(3):26-30
    Department of Orthopaedics, Seth GS Medical College and KEM Hospital, Mumbai, India.
    Introduction: Peritrochanteric fractures are common injuries occurring in elderly patients. Surgeries for these fractures are associated with significant blood loss. Intravenous tranexamic acid has a proven track record in many orthopaedic surgeries including trauma, arthroplasty and spine surgeries. Read More

    Combined effect of substance P and curcumin on cutaneous wound healing in diabetic rats.
    J Surg Res 2017 May 28;212:130-145. Epub 2017 Jan 28.
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
    Background: Our earlier studies demonstrated that topically applied substance P (SP) or curcumin on excision skin wound accelerated the wound healing in streptozotocin-induced diabetic rats. In the present study, we aimed to evaluate the wound healing potential of combination of SP and curcumin in diabetic rats.

    Materials And Methods: Open cutaneous excision wound was created on the back of each of the 60 diabetic rats. Read More

    Tehran's Tie: A simple trick to fix the trocar to the abdominal wall and close the entry site of first trocar in laparoscopic surgery.
    Asian J Endosc Surg 2017 May;10(2):216-218
    Ayatollah Kashani Social Security Hospital, Tehran, Iran.
    Introduction: Trocar dislodgment can occur frequently during minimally invasive surgery. Closing the entry port at the fascial layer after the end of a long laparoscopic surgery is time-consuming. Here, I introduce Tehran's Tie, a simple trick to overcome these problems. Read More

    Chitosan-Poly(caprolactone) Nanofibers for Skin Repair.
    J Mater Chem B Mater Biol Med 2017 Mar 3;5(9):1822-1833. Epub 2017 Feb 3.
    Department of Materials Science & Engineering, University of Washington, Seattle, Washington 98195, USA.
    Dermal wounds, both acute and chronic, represent a significant clinical challenge and therefore the development of novel biomaterial-based skin substitutes to promote skin repair is essential. Nanofibers have garnered attention as materials to promote skin regeneration due to the similarities in morphology and dimensionality between nanofibers and native extracellular matrix proteins, which are critical in guiding cutaneous wound healing. Electrospun chitosan-poly(caprolactone) (CPCL) nanofiber scaffolds, which combine the important intrinsic biological properties of chitosan and the mechanical integrity and stability of PCL, were evaluated as skin tissue engineering scaffolds using a mouse cutaneous excisional skin defect model. Read More

    Does Negative-Pressure Wound Therapy for the Open Abdomen Benefit the Patient? A Retrospective Cohort Study.
    Adv Skin Wound Care 2017 Jun;30(6):256-261
    Bojan Krebs, MD, PhD, and Tomaž Jagrič, MD, PhD, are General Surgeons, Department of Abdominal Surgery, University Clinical Centre Maribor, Slovenia. The authors have disclosed they have no financial relationships related to this article. Submitted June 17, 2015; accepted in revised form January 8, 2016.
    Objective: Negative-pressure wound therapy (NPWT) is the most modern and sophisticated method of temporary abdominal closure. The aim of the study was to determine the significant predictors for mortality in patients with NPWT.

    Setting: University Clinical Centre Maribor, Slovenia MATERIALS AND METHODS:: The authors performed a retrospective cohort study of all patients treated with NPWT between January 1, 2011, and December 31, 2014. Read More

    Silica nanoparticles as sources of silicic acid favoring wound healing in vitro.
    Colloids Surf B Biointerfaces 2017 Jul 24;155:530-537. Epub 2017 Apr 24.
    Biomineral Research Group, MRC Elsie Widdowson Laboratory, Cambridge CB1 9NL, UK; Biomineral Research Group, Department of Veterinary Medicine, University of Cambridge, Madingley Rd, Cambridge CB3 0ES, UK.
    There is good evidence that certain silicon-containing materials promote would healing and their common feature is the delivery of orthosilicic acid (Si(OH)4) either directly or following metabolism. In this respect, amorphous silica nanoparticles (NP), which dissolve in aqueous environments releasing up to 2mM orthosilicic acid, may be appropriate 'slow release' vehicles for bioactive silicon. Here we studied the impact of silica NP suspensions (primary particles∼10nm) in undersaturated conditions (below 2mM Si) with differing degrees of surface charge and dissolution rate on human dermal fibroblasts (CCD-25SK cells) viability, proliferation and migration in a cellular wound model. Read More

    Modified components separation technique: experience treating large, complex ventral hernias at a University Hospital.
    Hernia 2017 May 9. Epub 2017 May 9.
    IVO, Valencia, Spain.
    Background: An increasing number of patients have large or complex abdominal wall defects. Component separation technique (CST) is a very effective method for reconstructing complex midline abdominal wall defects in a manner that restores innervated muscle function without excessive tension. Our goal is to show our results by a modified CST for treating large ventral hernias. Read More

    EVALUATION OF EFFECTIVENESS IN A NOVEL WOUND HEALING OINTMENT-CROCODILE OIL BURN OINTMENT.
    Afr J Tradit Complement Altern Med 2017 23;14(1):62-72. Epub 2016 Nov 23.
    State Key Laboratory of Cellular Stress Biology, State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China.
    Background: Crocodile oil and its products are used as ointments for burns and scalds in traditional medicines. A new ointment formulation - crocodile oil burn ointment (COBO) was developed to provide more efficient wound healing activity. The purpose of the study was to evaluate the burn healing efficacy of this new formulation by employing deep second-degree burns in a Wistar rat model. Read More

    Guided bone regeneration with recombinant human bone morphogenetic protein 9 loaded on either deproteinized bovine bone mineral or a collagen barrier membrane.
    Clin Implant Dent Relat Res 2017 May 2. Epub 2017 May 2.
    Department of Periodontology, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida.
    Background: Recombinant human bone morphogenetic protein 9 (rhBMP9) has been considered the most osteoinductive growth factor of the BMP-family and has much translation potential for guided bone regeneration (GBR) procedures.

    Purpose: The aim of this study was to compare bone formation using rhBMP9 loaded with different carrier systems including deprotenized bovine bone mineral (BioOss, BO) or collagen barrier membranes (BioGide, BG) in a rabbit GBR model.

    Materials And Methods: rhBMP9 was loaded either on BO; named BO/BMP9, or BG; named BG/BMP9 to investigate the better carrier system for rhBMP9. Read More

    Use of Ovine-based Collagen Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressings to Help Improve Clinical Outcomes in Lower Extremity Wounds: A Retrospective Cohort Study.
    Wounds 2017 Apr;29(4):107-114
    West Boca Center for Wound Healing, Boca Raton, FL.
    Dressings that provide broad spectrum metalloprotease reduction along with inherent aspects of an extracellular matrix may contribute to improved wound healing outcomes and shorter treatment times.

    Objective: The author performed a retrospective case series analysis to determine the clinical outcomes of regular debridement with the use of ovine-based collagen extracellular matrix dressings and gentian violet/methylene blue polyurethane antibacterial foam dressings in treating 53 patients with 53 chronic lower extremity wounds (diabetic foot ulcers [DFUs], venous leg ulcers, and heel pressure ulcers).

    Materials And Methods: Patients were treated twice weekly in an outpatient clinic for the first 4 weeks and weekly thereafter until closure. Read More

    Editor's Choice - Arteriotomy Closure Devices in EVAR, TEVAR, and TAVR: A Systematic Review and Meta-analysis of Randomised Clinical Trials and Cohort Studies.
    Eur J Vasc Endovasc Surg 2017 Jul 21;54(1):104-115. Epub 2017 Apr 21.
    Department of Surgery, Division of Vascular Surgery, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
    Objectives: Cardiac and vascular surgery benefit from percutaneous interventions. Arteriotomy closure devices (ACDs) enable minimally invasive access to the common femoral artery (CFA). The objective of this review was to assess the differences between ACDs and surgical cut down (SCD) of the CFA regarding the number of complications, duration of surgery (DOS), and hospital length of stay (HLOS). Read More

    Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice.
    Sci Transl Med 2017 Apr;9(386)
    Collaborative Research Center (SFB-TR67) "Functional Biomaterials for Controlling Healing Processes in Bone and Skin-From Material Science to Clinical Application," Leipzig and Dresden, Germany.
    Excessive production of inflammatory chemokines can cause chronic inflammation and thus impair cutaneous wound healing. Capturing chemokine signals using wound dressing materials may offer powerful new treatment modalities for chronic wounds. Here, a modular hydrogel based on end-functionalized star-shaped polyethylene glycol (starPEG) and derivatives of the glycosaminoglycan (GAG) heparin was customized for maximal chemokine sequestration. Read More

    Spatiotemporal Evolution of the Wound Repairing Process in a 3D Human Dermis Equivalent.
    Adv Healthc Mater 2017 Apr 13. Epub 2017 Apr 13.
    Center for Advanced Biomaterials for HealthCare@CRIB, Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, 80125, Naples, Italy.
    Several skin equivalent models have been developed to investigate in vitro the re-epithelialization process occurring during wound healing. Although these models recapitulate closure dynamics of epithelial cells, they fail to capture how a wounded connective tissue rebuilds its 3D architecture until the evolution in a scar. Here, the in vitro tissue repair dynamics of a connective tissue is replicated by using a 3D human dermis equivalent (3D-HDE) model composed of fibroblasts embedded in their own extracellular matrix (ECM). Read More

    The Use of Acellular Urinary Bladder Matrix as Coverage for Fasciocutaneous Free Flap Donor Sites: An Alternative to Traditional Grafting Procedures.
    J Oral Maxillofac Surg 2017 Mar 18. Epub 2017 Mar 18.
    Assistant Professor, Oral and Maxillofacial Surgery, Oral, Head & Neck Oncology and Microvascular Surgery, The University of Texas Health Science Center at Houston, Houston, TX.
    Purpose: The purpose of this review is to 1) evaluate our early experience with urinary bladder matrix as a dressing for the management of complex wounds subsequent to fasciocutaneous or osteocutaneous vascularized tissue harvests, 2) assess coverage of exposed tendons and the duration of granulation and epithelial coverage, and 3) assess esthetic and functional outcomes compared with traditional means for the management of vascularized tissue harvest sites.

    Patients And Methods: This prospective study consisted of 8 consecutive patients in whom a substantial cutaneous component was harvested as part of a vascularized tissue reconstruction, which did not permit for primary closure (n = 7) or had skin graft failure (exposed tendon) that required additional treatment (n = 1).

    Results: Functional and esthetic outcomes were comparable to those of traditional methods of donor site closure as determined by clinical evaluation and subjective assessment by the patient. Read More

    Abietic acid isolated from pine resin (Resina Pini) enhances angiogenesis in HUVECs and accelerates cutaneous wound healing in mice.
    J Ethnopharmacol 2017 May 4;203:279-287. Epub 2017 Apr 4.
    College of Korean Medicine, Gachon University, Seongnam 461-701, South Korea. Electronic address:
    Ethnopharmacological Relevance: Resin known as Resina Pini is listed in the Korean and Japanese pharmacopoeias and has been used for treating skin wounds and inflammation. Resin is composed of more than 50% abietic acid and 10% neutral substances.

    Objective: In the present study, the wound-healing effects of abietic acid and the possible underlying mechanism of action were investigated in various in vitro and in vivo models. Read More

    Wound Healing Activity of Extracts and Formulations of Aloe vera, Henna, Adiantum capillus-veneris, and Myrrh on Mouse Dermal Fibroblast Cells.
    Int J Prev Med 2017 10;8:18. Epub 2017 Mar 10.
    Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Background: Among the most important factors in wound healing pathways are transforming growth factor beta1 and vascular endothelial growth factor. Fibroblasts are the main cell in all phases wound closure. In this study, the extracts of plant materials such as Adiantum capillus-veneris, Commiphora molmol, Aloe vera, and henna and one mixture of them were used to treatment of normal mouse skin fibroblasts. Read More

    Animal Bite Injuries in Children: Review of Literature and Case Series.
    Int J Clin Pediatr Dent 2017 Jan-Mar;10(1):67-72. Epub 2017 Feb 27.
    Assistant Professor,Department of Oral and Maxillofacial Surgery, Postgraduate Institute of Dental Sciences, Rohtak, Haryana, India.
    Introduction: Maxillofacial region in children is particularly vulnerable to animal bite injuries. These injuries may range from insignificant scratches to life-threatening neck and facial injuries. Children are the common victims, particularly of dog bites. Read More

    Evaluating the use of octyl-2-cyanoacrylate in unilateral cleft lip repair.
    Natl J Maxillofac Surg 2016 Jul-Dec;7(2):153-158
    Department of Oral and Maxillofacial Surgery, SGT Dental College, Gurgaon, Haryana, India.
    Background: Facial cosmetic results are one of the most concerning issues for the parents who get their children operated for cleft lip. Moreover, the postoperative care of the surgical site, the discomfort associated with the suture removal, and additional visit for suture removal are other reasons which encourages one to use any new technologies that may replace the need for suture placement. In this study, we used octyl-2-cyanoacrylate, a tissue adhesive which offers a viable alternative to traditional techniques without compromising optimal wound closure. Read More

    American Brachytherapy Society consensus statement for soft tissue sarcoma brachytherapy.
    Brachytherapy 2017 May - Jun;16(3):466-489. Epub 2017 Mar 23.
    Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
    Purpose: Radiation therapy represents an essential treatment option in the management of soft tissue sarcomas (STS). Brachytherapy represents an important subset of radiation therapy techniques used for STS, with evolving indications and applications. Therefore, the purpose of this guideline was to update clinicians regarding the data surrounding brachytherapy (BT) and provide recommendations for the utilization of BT in patients with STS. Read More

    Retrospective Evaluation of Percutaneous Access for TEVAR and EVAR: Time to Make it the Standard Approach?
    Rofo 2017 Apr 23;189(4):347-355. Epub 2017 Mar 23.
    Institute for Diagnostic and Interventional Radiology, Klinikum Oldenburg AöR, Oldenburg, Germany.
    Introduction To evaluate the safety of percutaneous endovascular aortic repair and the relationship of access site characteristics to complications Materials and Methods All patients undergoing percutaneous TEVAR, EVAR and FEVAR procedures from January 2010 to May 2016 were retrospectively analysed for incidence of complications and their relationship to various access site characteristics like access artery size, degree of vessel calcification, skin to artery distance and sheath to artery ratio. Hemostasis occurring within 15 min after suture closure with or without manual compression was defined as primary hemostasis. Results 92 patients with 142 femoral access sites were included in the study. Read More

    Cost-effective Alternative for Negative-pressure Wound Therapy.
    Plast Reconstr Surg Glob Open 2017 Feb 6;5(2):e1211. Epub 2017 Feb 6.
    Section of Plastic and Reconstructive Surgery, Department of Surgery, University of Chicago Medicine and Biological Sciences, Chicago, Ill.; and Department of Therapy Services, University of Chicago Medical Center, Chicago, Ill.
    Background: Current predominantly used equipments for negative-pressure wound therapy (NPWT) are expensive. In current healthcare climate continually emphasizing cost containment, importance in developing more cost-effective alternatives cannot be understated. Previously, therapeutically equivalent methods of providing NPWT was demonstrated using just low-cost, universally available supplies, coined Gauze-SUCtion (GSUC). Read More

    In situ development and application of natural coatings on non-absorbable sutures to reduce incision site infections.
    J Wound Care 2017 Mar;26(3):115-120
    Research Assistant, Research and Development Division, National Textile University, Faisalabad, Punjab, Pakistan.
    Objective: The purpose of the study was the development of a suture line that has antibacterial properties and reduces the chance of wound infection thus facilitating the healing process.

    Method: Hydrolysed chitosan, turmeric powder and clove oil were used in different proportions to formulate antimicrobial coating for the polyethylene terephthalate (PET) and polyamide (Nylon 6) threads. The threads were coated using a lab-scale yarn sizing machine. Read More

    Vacuum sealing drainage as a pre-surgical adjunct in the treatment of complex (open) hand injuries: Report of 17 cases.
    Orthop Traumatol Surg Res 2017 May 6;103(3):461-464. Epub 2017 Mar 6.
    Department of Upper Extremity Orthopedics, Eastern Hospital of the First Affiliated Hospital, Sun Yat-sen University, 510080 Guang Zhou, China. Electronic address:
    Background: Few studies have been conducted to explore the use of the vacuum sealing drainage (VSD) technique in complex hand injuries. The aim of this study was to report outcomes in patients with complex hand injuries receiving VSD as a coadjuvant treatment prior to second-stage surgery.

    Methods: This case series study retrospectively reviewed the patients who underwent VSD for treatment of hand injuries. Read More

    Human Reticular Acellular Dermal Matrix in the Healing of Chronic Diabetic Foot Ulcerations that Failed Standard Conservative Treatment: A Retrospective Crossover Study.
    Wounds 2017 Feb;29(2):39-45
    Angiogenesis Foundation, Cambridge, MA.
    Background: Acellular matrices have been successfully used to heal indolent diabetic foot ulcers (DFUs). These tissues include allogenic dermis as well as xenograft dermis, pericardium, and small intestine submucosa. While all of these tissues show promise for healing DFUs, dermal-derived matrices have shown considerable potential. Read More

    Enzymatic Debridement of Chronic Nonischemic Diabetic Foot Ulcers: Results of a Randomized, Controlled Trial.
    Wounds 2017 Feb 27. Epub 2017 Feb 27.
    Smith & Nephew Inc, Fort Worth, TX andDepartment of Pediatrics, University of North Texas Health Science Center.
    Objective: The aim of this randomized, controlled multicenter trial was to evaluate the clinical outcomes associated with the use of clostridial collagenase ointment (CCO) for up to 12 weeks in 215 patients with type 1 or type 2 diabetes mellitus and a neuropathic, nonischemic diabetic foot ulcer (DFU).

    Materials And Methods: Patients were randomized into either a group receiving CCO applied once daily at a thickness of ~2 mm or a group receiving standard care (SC) consisting of a daily application of a hydrogel as needed to maintain a moist ulcer environment. All ulcers were covered with a nonadherent foam dressing that was changed once daily, and sharp debridement was allowed when the investigators deemed it medically warranted. Read More

    Vancomycin Powder Regimen for Prevention of Surgical Site Infection in Complex Spine Surgeries.
    Clin Spine Surg 2017 Mar 6. Epub 2017 Mar 6.
    *Department of Orthopedic Surgery, UT Southwestern Medical Center, Dallas, TX †Department of Orthopedic Surgery (UPMC), University of Pittsburgh Medical Center, Pittsburgh, PA ‡United States Air Force Anchorage, Anchorage, AK §Brigham and Women Hospital, Boston, MA.
    Study Design: In total, 496 patients of a single surgeon cohort examining the surgical-site infection (SSI) rates with the addition of vancomycin powder in both diabetic and revision spine surgery cases. A historical control group of 652 patients were compared from the same surgeon over an earlier time period before the inception of using vancomycin powder prophylaxis.

    Objective: The objective of this study was to describe and compare the rates of infection in high-risk patient populations while using vancomycin powder. Read More

    Incisional Hernia After Liver Transplant.
    Exp Clin Transplant 2017 Feb;15(Suppl 1):185-189
    Department of General Surgery, Baskent University, Ankara, Turkey.
    Objectives: An incisional hernia seriously burdens the quality of life after liver transplant. The incidence of incisional hernia after liver transplant is reported to be 4% to 20%. Here, we evaluated incisional hernias that occurred after adult liver transplant and incisional hernias intentionally made in infant liver transplant procedures. Read More

    Histopathological assessment of OASIS Ultra on critical-sized wound healing: a pilot study.
    J Cutan Pathol 2017 Jun 23;44(6):523-529. Epub 2017 Mar 23.
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts.
    Background: Dermatopathologists assess wounds secondary to trauma, infection, or oncologic resection that can be challenging to reconstruct. OASIS Ultra, an extracellular matrix, has been described for use in chronic and burn wounds. The aim of this pilot study is to assess wound healing in post-traumatic and infective wounds treated with OASIS using histological markers of repair. Read More

    Quantitative difference of acute intraoperative expansion in various body regions.
    Eur Rev Med Pharmacol Sci 2017 Feb;21(3):454-459
    Department of Surgical Sciences, Plastic Surgery Division, University of Parma, Parma, Italy; Cutaneous, Mini-invasive, Regenerative and Plastic Surgery Unit, Parma University Hospital, Parma, Italy.
    Objective: To investigate the efficacy of intraoperative sustained limited expansion (ISLE) by examining the ex vivo biomechanical properties of acutely expanded skin flaps.

    Materials And Methods: Fourteen fresh male cadavers were tested. On both sides of each cadaver, a 4 × 10 cm, the laterally based flap was raised at the external auditory canal of the scalp and a 15 × 8 cm, the proximately based flap was raised at the lateral arm, anterior thorax, and lateral thigh. Read More

    Cultured Human Epidermis Combined With Meshed Skin Autografts Accelerates Epithelialization and Granulation Tissue Formation in a Rat Model.
    Ann Plast Surg 2017 Jun;78(6):651-658
    From the *Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Syogoin Sakyo-ku, Kyoto; †Department of Plastic and Reconstructive Surgery, Kansai Medical University, Hirakata, Osaka; and ‡Japan Tissue Engineering, Co., Ltd., Miyakitadori, Gamagori, Aichi, Japan.
    Introduction: As the take rate of cultured epidermal autografts in burn wound treatment is variable, widely expanded meshed auto skin grafts are often used in combination with cultured epidermal autograft to increase the take rate and achieve definitive wound coverage. However, a long time (3-4 weeks) required to prepare a cultured epidermis sheet is a disadvantage. Allogeneic cultured epidermis can be prepared in advance and cryopreserved to be used in combination with auto meshed skin grafts for treating third-degree burns. Read More

    In vitro wound healing and cytotoxic activity of the gel and whole-leaf materials from selected aloe species.
    J Ethnopharmacol 2017 Mar 14;200:1-7. Epub 2017 Feb 14.
    Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address:
    Ethnopharmacological Relevance: Aloe vera is one of the most important medicinal plants in the world with applications in the cosmetic industry and also in the tonic or health drink product market. Different parts of Aloe ferox and Aloe marlothii are used as traditional medicines for different applications. Although wound healing has been shown for certain aloe gel materials (e. Read More

    Complex Ventral Hernia Repair with Acellular Dermal Matrices: Clinical and Quality of Life Outcomes.
    Am Surg 2017 Feb;83(2):141-147
    Acellular dermal matrices (ADMs) are used in conjunction with complex hernia repair, but their efficacy is often debated. This study assesses clinical and quality of life (QOL) outcomes in multiply comorbid patients undergoing complex ventral hernia repair using ADMs. After obtaining institutional review board approval, a prospective study was conducted evaluating patients undergoing complex ventral incisional hernia repair with abdominal wall reconstruction (AWR) using either human (Flex HD) or porcine ADM (Strattice). Read More

    Simple Skin-Stretching Device in Assisted Tension-Free Wound Closure.
    Ann Plast Surg 2017 Mar;78(3 Suppl 2):S52-S57
    From the *Division of Plastic Surgery, Department of Surgery, Buddhist Tzu-Chi General Hospital; †Department of Surgery, Tzu-Chi University, Hualien; and ‡Department of Surgery, Division of Plastic Surgery, Buddhist Tzu-Chi Dalin General Hospital, Chiayi, Taiwan.
    Background: Numerous conventional wound reconstruction methods, such as wound undermining with direct suture, skin graft, and flap surgery, can be used to treat large wounds. The adequate undermining of the skin flaps of a wound is a commonly used technique for achieving the closure of large tension wounds; however, the use of tension to approximate and suture the skin flaps can cause ischemic marginal necrosis. The purpose of this study is to use elastic rubber bands to relieve the tension of direct wound closure for simultaneously minimizing the risks of wound dehiscence and wound edge ischemia that lead to necrosis. Read More

    Efficacy and safety of small intestinal submucosa in dural defect repair in a canine model.
    Mater Sci Eng C Mater Biol Appl 2017 Apr 20;73:267-274. Epub 2016 Dec 20.
    Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China. Electronic address:
    Dural defects are a common problem, and inadequate dural closure can lead to complications. Several types of dural substitute materials have recently been discarded or modified owing to poor biocompatibility or mechanical properties and adverse reactions. The small intestinal submucosa (SIS) is a promising material used in a variety of applications. Read More

    Modified Beef Tongue Model for Fourth-Degree Laceration Repair Simulation.
    Obstet Gynecol 2017 Mar;129(3):491-496
    Department of Obstetrics and Gynecology, Division of Urogynecology and Pelvic Reconstructive Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
    Background: An existing model for fourth-degree laceration repair uses beef tongue with plastic or vinyl tubing. This modified model substitutes beef tripe for the anal mucosa and chicken leg muscles for the anal sphincter muscle analogs to create a realistic model.

    Method: Tripe is tunneled through the body of the trimmed beef tongue and sutured like an ostomy to simulate the anal canal. Read More

    On-Demand Dissolution of Chemically Cross-Linked Hydrogels.
    Acc Chem Res 2017 Feb 7;50(2):151-160. Epub 2017 Feb 7.
    Departments of Chemistry, Biomedical Engineering, and Medicine, Boston University , 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
    The formation and subsequent on-demand dissolution of chemically cross-linked hydrogels is of keen interest to chemists, engineers, and clinicians. In this Account, we summarize our recent advances in the area of dissolvable chemically cross-linked hydrogels and provide a comparative discussion of other recent hydrogel systems. Using biocompatible macromonomers, we developed a library of cross-linked dendritic hydrogels that possess favorable properties, including biocompatibility, tissue adhesion, and swelling. Read More

    The effectiveness of demineralized cortical bone matrix in a chronic rotator cuff tear model.
    J Shoulder Elbow Surg 2017 Apr 2;26(4):619-626. Epub 2017 Feb 2.
    The John Scales Centre for Biomedical Engineering, Institute of Orthopaedics and Musculoskeletal Science, Division of Surgery and Interventional Science, University College London, The Royal National Orthopaedic Hospital Trust, Stanmore, Middlesex, UK.
    Background: The purpose of this study was to assess the effect of demineralized bone matrix (DBM) on rotator cuff tendon-bone healing. The hypothesis was that compared with a commercially available dermal matrix scaffold, DBM would result in a higher bone mineral density and regenerate a morphologically superior enthesis in a rat model of chronic rotator cuff degeneration.

    Methods: Eighteen female Wistar rats underwent unilateral detachment of the supraspinatus tendon. Read More

    Use of locking barbed sutures in foot and ankle surgery. A case series.
    Foot Ankle Surg 2017 Mar 23;23(1):57-61. Epub 2016 Apr 23.
    Netcare Linksfield Orthopaedic Sports & Rehabilitation Centre (Clinic), Johannesburg, South Africa; Orthopaedic Department, University of the Witwatersrand, Johannesburg, South Africa.
    Background: Barbed sutures represent a novel technique for wound closure. By distributing tension forces across the length of a wound, it results in better wound healing. A recent article from Chowdhry et al. Read More

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