2,570 results match your criteria Materials for Wound Closure


Pomegranate-Like CuO@SiO Nanospheres as HO Self-Supplying and Robust Oxygen Generators for Enhanced Antibacterial Activity.

ACS Appl Mater Interfaces 2021 May 11. Epub 2021 May 11.

College of Materials Science and Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Rd., Qingdao, Shandong 266042, China.

Reactive oxygen species (ROS)-induced nanosystems represent one of the most essential, efficient, and encouraging nanobactericides for eliminating bacterial infection concerning the increasing resistance threats of existing antibiotics. Among them, Fenton-type metal peroxide nanoparticles are exciting nanomaterials with intriguing physiochemical properties, yet the study of this antimicrobial agent is still in its infancy. Herein, a robust pH-responsive Fenton nanosystem is constructed by the assembly of copper peroxide nanodots in pomegranate-like mesoporous silica nanoshells (CuO@SiO) that are capable of self-supplying HO and sustainably generating O. Read More

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Preparation and evaluation of an innovative antibacterial bi-layered composite dressing for skin wound healing.

J Tissue Viability 2021 Apr 30. Epub 2021 Apr 30.

Weihai Food and Drug Inspection Testing Center, No.52, Xin Wei Road, Weihai, Shandong Province, 264200, PR China.

Aim Of The Study: The aim of the current study was to develop collagen-based bi-layered composite dressings with antibacterial property and evaluate the efficiency for wound healing.

Materials And Methods: A bi-layered composite wound dressing was fabricated using two marine biomacromolecules (collagen and chitosan or carboxymethyl chitosan). Non-crosslinked and N-Ethyl-N'-(3-dimethylaminopropyl) carbodiimide/N-Hydroxy succinimide (EDC/NHS) cross-linked collagen sponges fabricated by vacuum freeze-drying technology was used as the inner layer. Read More

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Exosome loaded genipin crosslinked hydrogel facilitates full thickness cutaneous wound healing in rat animal model.

Drug Deliv 2021 Dec;28(1):884-893

Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, PR China.

Full thickness cutaneous wound therapy and regeneration remains a critical challenge in clinical therapeutics. Recent reports have suggested that mesenchymal stem cells exosomes therapy is a promising technology with great potential to efficiently promote tissue regeneration. Multifunctional hydrogel composed of both synthetic materials and natural materials is an effective carrier for exosomes loading. Read More

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December 2021

Robust Electrospun Nanofibers from Chemosynthetic Poly(4-hydroxybutyrate) as Artificial Dural Substitute.

Macromol Biosci 2021 May 5:e2100134. Epub 2021 May 5.

Key Lab of Biobased Polymer Materials of Shandong Provincial Education Department, College of Polymer Science and Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Road, Qingdao, 266042, P. R. China.

Bioresorbable poly(4-hydroxybutyrate) (P4HB) may fulfill the specific requirements that are necessary for a dural substitute, including its high elasticity, long-term strength retention properties, and the biocompatibility without significant accumulation of acidic degradation products. However, commercial P4HB can only be produced by the bacterial fermentation, which limits its applications in the cerebrospinal system due to higher endotoxin restriction. Meanwhile, P4HB can be prepared via the ring-opening polymerization of γ-butyrolactone. Read More

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Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing.

J Nanobiotechnology 2021 May 5;19(1):130. Epub 2021 May 5.

Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, P. R. China.

Excessive expression of matrix metalloproteinase 9 (MMP-9) impedes healing of diabetic chronic wounds, thus wound dressing that could effectively inhibit the expression of MMP-9 offers significant clinical translation for diabetic wound healing. Herein, a hybrid hydrogel dressing was developed for localized and sustained delivery of MMP-9 siRNA (siMMP-9). siMMP-9 was complexed with Gly-TETA (GT), the GT/siMMP9 complex was then loaded into a thermosensitive hydrogel based on Pluronic F-127 (PF) and methylcellulose (MC). Read More

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SETD2 epidermal deficiency promotes cutaneous wound healing via activation of AKT/mTOR Signalling.

Cell Prolif 2021 May 5:e13045. Epub 2021 May 5.

State Key Laboratory of Oncogenes and Related Genes, School of Medicine and School of Biomedical Engineering, Renji Med-X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.

Objectives: Cutaneous wound healing is one of the major medical problems worldwide. Epigenetic modifiers have been identified as important players in skin development, homeostasis and wound repair. SET domain-containing 2 (SETD2) is the only known histone H3K36 tri-methylase; however, its role in skin wound healing remains unclear. Read More

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Moist wound dressing and its application in distant skin flap in cats.

Vet World 2021 Mar 23;14(3):734-738. Epub 2021 Mar 23.

Program Study of Veterinary Professional, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.

Background And Aim: Wound healing is a dynamic and complex process that requires an appropriate environment to promote healing process. The healing of distant flaps in cats is determined by vascularization, nutrient sufficiency for the cells, and stability of skin flaps. This study aims to evaluate the healing of distant flaps treated with moist wound dressing through subjective and objective observation in five cats with wounds in the forelimb and hindlimb area to determine the time to cut the skin flaps from the donor site. Read More

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Fungal Chitosan-Derived Biomaterials Modified with as Potential Hemostatic Agents-Development and Characterization.

Polymers (Basel) 2021 Apr 15;13(8). Epub 2021 Apr 15.

Faculty of Mechanics and Technology, Rzeszow University of Technology, Kwiatkowskiego 4 Street, 37-450 Stalowa Wola, Poland.

Massive blood loss is still a great challenge for modern medicine. To stop the hemorrhage during the surgery or after injury apart from suturing or electrocoagulation, the most efficient method of hemostasis restoration is the use of hemostatic agents. Although there are numerous products on the market, there is still a need for biomaterials that are capable of fast and efficient bleeding management without affecting wound closure or embolism. Read More

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Silver nanoparticles green synthesis via cyanobacterium Phormidium sp.: characterization, wound healing, antioxidant, antibacterial, and anti-inflammatory activities.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):3083-3096

Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.

Objective: Green synthesis of silver nanoparticles (AgNPs) using cyanobacterial platforms is becoming more popular nowadays. In this study, the filamentous non-heterocystous cyanobacterium Phormidium sp. was used for AgNPs production. Read More

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Does Phototherapy Promote Wound Healing? Limitations of Blue Light Irradiation.

Wounds 2021 Apr;33(4):91-98

Clinic for Plastic, Reconstructive, Hand and Burn Surgery, BG Trauma Center, Eberhard-Karls-Universität, Tübingen, Germany.

Introduction: Phototherapy is gaining increased attention in the research and treatment of various diseases. In particular, the use of blue light seems to bear promise, owing to its antimicrobial and immune-modulating properties; however, research focused on the effects of blue light on keratinocytes and reepithelization is rare. In addition, few studies to date have evaluated devices that are used in daily hospital routine. Read More

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Efficacy of Closed Incision Negative Pressure Wound Therapy on Abdominal Donor Site After Free Flap Breast Reconstruction.

Wounds 2021 Apr;33(4):81-85

Institute for Reconstructive Surgery, Houston Methodist Hospital, Weill Cornell Medicine, Houston, Texas.

Introduction: Negative pressure wound therapy (NPWT) has been used to treat acute and chronic wounds in a variety of scenarios. Specifically, in autologous breast reconstruction, studies investigating the use of closed incision NPWT (ciNPWT) in breast surgery are lacking.

Objective: The aim of this study was to analyze the use of ciNPWT at the abdominal donor site following deep inferior epigastric perforator (DIEP) flap breast reconstruction. Read More

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Single flap approach with or without enamel matrix derivative in the treatment of severe supraosseous defects: a retrospective study.

Clin Oral Investig 2021 Apr 14. Epub 2021 Apr 14.

Research Centre for the Study of Periodontal and Peri-Implant Diseases, University of Ferrara, Corso Giovecca 203, 44121, Ferrara, Italy.

Aim: To comparatively evaluate the clinical effectiveness of the single flap approach (SFA) with and without enamel matrix derivative (EMD) in the treatment of supraosseous defects (SDs) associated with deep pockets.

Materials And Methods: Twenty patients, each contributing one SD associated with a deep (≥ 6 mm) pocket and treated with buccal SFA either alone (SFA group; n = 10) or in combination with EMD (SFA+EMD group; n =10), were retrospectively selected. Clinical parameters (probing depth, PD; clinical attachment level, CAL; gingival recession, REC) had been assessed at pre-surgery and 12 months post-surgery. Read More

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Practice of wound closure techniques among emergency physicians and surgeons in Makkah City Hospitals in Saudi Arabia.

J Public Health Res 2021 Apr 13. Epub 2021 Apr 13.

Plastic, Reconstructive and Hand Surgery, Specialized Surgery Department, King Abdullah Medical City.

Background: Wound suturing is a procedure performed by medical and surgical specialists. While there are many different suturing techniques and materials used to treat patients, the choice of which to employ depends on different variables that affect the outcome of the procedure.

Design And Methods: This is a cross-sectional study conducted to provide descriptive data regarding the practice of wound closure techniques, and to develop an awareness of scar formation factors. Read More

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Chitosan/alginate/hyaluronic acid polyelectrolyte composite sponges crosslinked with genipin for wound dressing application.

Int J Biol Macromol 2021 Apr 10;182:512-523. Epub 2021 Apr 10.

Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, Tianjin 300457, PR China; Institute of Medical Support Technology, Academy of Military Sciences, Tianjin 300161, PR China. Electronic address:

Wound dressing composed of polyelectrolyte complexes (PECs), based on chitosan/alginate/hyaluronic acid (CS/ALG/HYA) crosslinked by genipin, was prepared by freeze-dried molding. Genipin as excellent natural biological crosslinker was chose for high biocompatibility and improving mechanical properties of materials. The CS/ALG/HYA sponges (CAHSs) were characterized by FTIR, XRD, DSC and SEM. Read More

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Engineering and polymeric composition of drug-eluting suture: A review.

J Biomed Mater Res A 2021 Apr 8. Epub 2021 Apr 8.

Centre for Bioengineering and Nanomedicine (Dunedin), Faculty of Dentistry, Division of Health Sciences, University of Otago, Dunedin, New Zealand.

Sutures are the most popular surgical implants in the global surgical equipment market. They are used for holding tissues together to achieve wound closure. However, controlling the body's immune response to these "foreign bodies" at site of infection is challenging. Read More

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Co-electrospun nanofibrous mats loaded with bitter gourd (Momordica charantia) extract as the wound dressing materials: in vitro and in vivo study.

BMC Complement Med Ther 2021 Apr 7;21(1):111. Epub 2021 Apr 7.

Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Interactive dressings are innovatively designed to interact with the wound surface and alter the wound environment to promote wound healing. In the current study, we integrated the physicochemical properties of Poly (caprolactone)/ Poly (vinyl alcohol)/Collagen (PCL/PVA/Col) nanofibers with the biological activities of Momordica charantia pulp extract to develop an efficient wound dressing. The electrospinning method was applied to fabricate the nanofibers, and the prepared wound dressings were thoroughly characterized. Read More

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Accelerated wound closure: Systematic evaluation of cellulose acetate effects on biologically active molecules release from amniotic fluid stem cells.

Biotechnol Appl Biochem 2021 Apr 7. Epub 2021 Apr 7.

Department of Mechanical, Materials and Manufacturing Engineering, Faculty of Science and Engineering, University of Nottingham Ningbo China, Ningbo, China.

Despite a lot of intensive research on cell-scaffold interaction, the focus is mainly on the capacity of construct scaffolds to regulate cell mobility, migration, and cytotoxicity. The effect of the scaffold's topographical and material properties on the expression of biologically active compounds from stem cells is not well understood. In this study, the influence of cellulose acetate (CA) on the electrospinnability of gelatin and the roles of gelatin-cellulose acetate (Ge-CA) on modulating the release of biologically active compounds from amniotic fluid stem cells (AFSCs) is emphasized. Read More

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Robust closure of post-endoscopic submucosal dissection perforation by microparticle-based wound dressing.

Mater Sci Eng C Mater Biol Appl 2021 Apr 24;123:111993. Epub 2021 Feb 24.

Polymers and Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan; Graduate School of Science and Technology, Degree Programs in Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan. Electronic address:

Endoscopic submucosal dissection (ESD) has been used as a minimally invasive cancer treatment for early-stage gastrointestinal cancer. However, cancer dissection in thin tissues, such as the duodenum and large intestine, often cause post-ESD and delayed perforation, which elicit severe complications. In this study, we report a microparticle-based wound dressing with hydrophobically-modified gelatin that can close the perforation after ESD. Read More

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Development of a silk fibroin-based multitask aerosolized nanopowder formula for efficient wound healing.

Int J Biol Macromol 2021 Mar 30;182:413-424. Epub 2021 Mar 30.

Nanomedicine Labs, Center for Materials Science (CMS), Zewail City of Science and Technology, 6th of October, Giza 12578, Egypt. Electronic address:

Most of the spray products in the market for wound healing applications are loaded with antibiotics that exert their antibacterial effect within the inflammatory stage of wound healing without demonstrating any effect in the subsequent proliferation stage. This study introduces a new aerosolized nanopowder (ANP) formula that not only exhibits antibacterial effect but also antioxidant and enhanced cell proliferation effects. Within the introduced ANP formula, Avicenna marina (Am) extract and neomycin (NM) antibiotic have been loaded within silk-fibroin nanoparticles (FB NPs). Read More

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Incorporating a structural extracellular matrix gradient into a porcine urinary bladder matrix-based hydrogel dermal scaffold.

J Biomed Mater Res A 2021 Apr 2. Epub 2021 Apr 2.

Fischell Department of Bioengineering, University of Maryland, College Park, Maryland, USA.

The increasing prevalence of chronic, nonhealing wounds necessitates the investigation of full-thickness skin substitutes conducive to host integration and wound closure. Extracellular matrix (ECM)-based hydrogel scaffolds mimic the physiological matrix environment of dermal cells, thereby conferring favorable cellular adhesion, infiltration, and proliferation. However, low-concentration ECM hydrogels rapidly lose mechanical strength as they degrade, leaving them susceptible to shrinkage from fibroblast-mediated contraction. Read More

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Single level posterolateral lumbar fusion in a New Zealand White rabbit () model: Surgical anatomy, operative technique, autograft fusion rates, and perioperative care.

JOR Spine 2021 Mar 23;4(1):e1135. Epub 2020 Dec 23.

Surgical and Orthopaedic Research Laboratories, Prince of Wales Clinical School University of New South Wales Sydney, Prince of Wales Hospital Sydney New South Wales Australia.

Introduction: The posterolateral lumbar fusion (PLF) New Zealand White (NZW) () rabbit model is a long-standing surgical technique for the preclinical evaluation of materials for spinal fusion. A detailed understanding of lumbar spine anatomy and perioperative care requirements of rabbits is imperative for correct execution of the model both scientifically and ethically. This study describes the preoperative procedures and surgical techniques used in single level PLF in a NZW rabbit model as it pertains to the animal husbandry, lumbar spine anatomy, anesthesia, surgical approach, and perioperative care of rabbits in a research setting. Read More

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Construction of heparin-based hydrogel incorporated with Cu5.4O ultrasmall nanozymes for wound healing and inflammation inhibition.

Bioact Mater 2021 Oct 9;6(10):3109-3124. Epub 2021 Mar 9.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai, 200011, China.

Excessive production of inflammatory chemokines and reactive oxygen species (ROS) can cause a feedback cycle of inflammation response that has a negative effect on cutaneous wound healing. The use of wound-dressing materials that simultaneously absorb chemokines and scavenge ROS constitutes a novel 'weeding and uprooting' treatment strategy for inflammatory conditions. In the present study, a composite hydrogel comprising an amine-functionalized star-shaped polyethylene glycol (starPEG) and heparin for chemokine sequestration as well as CuO ultrasmall nanozymes for ROS scavenging (CuO@Hep-PEG) was developed. Read More

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October 2021

An Antifouling and Antimicrobial Zwitterionic Nanocomposite Hydrogel Dressing for Enhanced Wound Healing.

ACS Biomater Sci Eng 2021 04 26;7(4):1621-1630. Epub 2021 Mar 26.

State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China.

Antibacterial hydrogels have received intensive interest in soft tissue repair, especially for preventing infections associated with impaired wound healing. However, developing an inherent antibacterial hydrogel dressing with antifouling ability without causing secondary damage to repaired tissues has proven to be promising and challenging. In this work, a mussel-inspired zwitterionic sulfobetaine acrylamide hydrogel incorporated with laponite (LAP) nanoplatelets and methacrylamide dopamine (DMA) has been developed for effective wound dressings, where LAP nanoplatelets and DMA endow the hydrogel with enhanced mechanical strength and substance adhesiveness, respectively. Read More

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Does the Lingual-Based Mucoperiosteal Flap Reduce Postoperative Morbidity Compared With the Buccal-Based Mucoperiosteal Flap After the Surgical Removal of Impacted Third Molars? A Meta-analysis Review.

J Oral Maxillofac Surg 2021 Feb 24. Epub 2021 Feb 24.

Professor, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong, China. Electronic address:

Purpose: The lingual-based mucoperiosteal flap, a novel flap, was unclear about the effects on the prognosis of surgery for impacted mandibular third molars. This study aimed to compare the lingual- and buccal-based mucoperiosteal flaps with respect to postoperative responses and complications.

Materials And Methods: A systematic review with a meta-analysis was designed and the PubMed, Cochrane Library, EMBASE, and Web of Science databases and Google Scholar from January 1, 2000 to April 30, 2020 were searched for randomized clinical trials. Read More

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February 2021

Mussel-inspired adhesive and polypeptide-based antibacterial thermo-sensitive hydroxybutyl chitosan hydrogel as BMSCs 3D culture matrix for wound healing.

Carbohydr Polym 2021 Jun 1;261:117878. Epub 2021 Mar 1.

College of Marine Life Science, Ocean University of China, Qingdao, 266003, PR China. Electronic address:

Hydrogels have gained great attentions as wound dressing. Binding to the tissue and preventing wound infection were the basic requirements for an "ideal dressing". We employed l-DOPA and ε-Poly-l-lysine to modify thermo-sensitive hydroxybutyl chitosan (HBC) to obtain (l-DOPA) - (ε-Poly-l-lysine)-HBC hydrogels (eLHBC). Read More

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Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing.

ACS Nano 2021 04 25;15(4):7078-7093. Epub 2021 Mar 25.

Frontier Institute of Science and Technology and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.

The design and development of a smart bioadhesive hydrogel sealant with self-healing and excellent antibacterial activity to achieve high wound closure effectiveness and post-wound-closure care is highly desirable in clinical applications. In this work, a series of adhesive antioxidant antibacterial self-healing hydrogels with promising traits were designed through dual-dynamic-bond cross-linking among ferric iron (Fe), protocatechualdehyde (PA) containing catechol and aldehyde groups and quaternized chitosan (QCS) to enable the closure of skin incisions and promotion of methicillin-resistant (MRSA)-infected wound healing. The dual-dynamic-bond cross-linking of a pH-sensitive coordinate bond (catechol-Fe) and dynamic Schiff base bonds with reversible breakage and re-formation equips the hydrogel with excellent autonomous healing and on-demand dissolution or removal properties. Read More

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HIF-1α controls palatal wound healing by regulating macrophage motility via S1P/S1P signaling axis.

Oral Dis 2021 Mar 23. Epub 2021 Mar 23.

Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

Objectives: To investigate the role of hypoxia-inducible factor 1α (HIF-1α) signaling, the expression profile of M1 and M2 macrophages, and the role of the sphingosine 1-phosphate (S1P)/S1P receptor system in palatal wound healing of heterozygous HIF-1α-deficient (HIF-1α HET) mice.

Materials And Methods: HIF-1α HET and wild-type (WT) littermates underwent palatal tissue excision at the mid-hard palate. Histological analysis, immunostaining, real-time PCR, Western blotting (WB), and cellular migration assays were performed to analyze wound closure and macrophage infiltration. Read More

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A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing.

Nat Commun 2021 03 15;12(1):1670. Epub 2021 Mar 15.

The University of Chicago, Ben May Department for Cancer Research, Chicago, IL, 60637, USA.

Effective healing of skin wounds is essential for our survival. Although skin has strong regenerative potential, dysfunctional and disfiguring scars can result from aberrant wound repair. Skin scarring involves excessive deposition and misalignment of ECM (extracellular matrix), increased cellularity, and chronic inflammation. Read More

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A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings.

Bioact Mater 2021 Sep 18;6(9):2829-2840. Epub 2021 Feb 18.

MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, PR China.

In recent years, the developed hemostatic technologies are still difficult to be applied to the hemostasis of massive arterial and visceral hemorrhage, owing to their weak hemostatic function, inferior wet tissue adhesion, and low mechanical properties. Herein, a mussel-inspired supramolecular interaction-cross-linked hydrogel with robust mechanical property (308.47 ± 29. Read More

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September 2021