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    Chitosan-Poly(caprolactone) Nanofibers for Skin Repair.
    J Mater Chem B Mater Biol Med 2017 Mar 3;5(9):1822-1833. Epub 2017 Feb 3.
    Department of Materials Science & Engineering, University of Washington, Seattle, Washington 98195, USA.
    Dermal wounds, both acute and chronic, represent a significant clinical challenge and therefore the development of novel biomaterial-based skin substitutes to promote skin repair is essential. Nanofibers have garnered attention as materials to promote skin regeneration due to the similarities in morphology and dimensionality between nanofibers and native extracellular matrix proteins, which are critical in guiding cutaneous wound healing. Electrospun chitosan-poly(caprolactone) (CPCL) nanofiber scaffolds, which combine the important intrinsic biological properties of chitosan and the mechanical integrity and stability of PCL, were evaluated as skin tissue engineering scaffolds using a mouse cutaneous excisional skin defect model. Read More

    Does Negative-Pressure Wound Therapy for the Open Abdomen Benefit the Patient? A Retrospective Cohort Study.
    Adv Skin Wound Care 2017 Jun;30(6):256-261
    Bojan Krebs, MD, PhD, and Tomaž Jagrič, MD, PhD, are General Surgeons, Department of Abdominal Surgery, University Clinical Centre Maribor, Slovenia. The authors have disclosed they have no financial relationships related to this article. Submitted June 17, 2015; accepted in revised form January 8, 2016.
    Objective: Negative-pressure wound therapy (NPWT) is the most modern and sophisticated method of temporary abdominal closure. The aim of the study was to determine the significant predictors for mortality in patients with NPWT.

    Setting: University Clinical Centre Maribor, Slovenia MATERIALS AND METHODS:: The authors performed a retrospective cohort study of all patients treated with NPWT between January 1, 2011, and December 31, 2014. Read More

    Silica nanoparticles as sources of silicic acid favoring wound healing in vitro.
    Colloids Surf B Biointerfaces 2017 Apr 24;155:530-537. Epub 2017 Apr 24.
    Biomineral Research Group, MRC Elsie Widdowson Laboratory, Cambridge CB1 9NL, UK; Biomineral Research Group, Department of Veterinary Medicine, University of Cambridge, Madingley Rd, Cambridge CB3 0ES, UK.
    There is good evidence that certain silicon-containing materials promote would healing and their common feature is the delivery of orthosilicic acid (Si(OH)4) either directly or following metabolism. In this respect, amorphous silica nanoparticles (NP), which dissolve in aqueous environments releasing up to 2mM orthosilicic acid, may be appropriate 'slow release' vehicles for bioactive silicon. Here we studied the impact of silica NP suspensions (primary particles∼10nm) in undersaturated conditions (below 2mM Si) with differing degrees of surface charge and dissolution rate on human dermal fibroblasts (CCD-25SK cells) viability, proliferation and migration in a cellular wound model. Read More

    Modified components separation technique: experience treating large, complex ventral hernias at a University Hospital.
    Hernia 2017 May 9. Epub 2017 May 9.
    IVO, Valencia, Spain.
    Background: An increasing number of patients have large or complex abdominal wall defects. Component separation technique (CST) is a very effective method for reconstructing complex midline abdominal wall defects in a manner that restores innervated muscle function without excessive tension. Our goal is to show our results by a modified CST for treating large ventral hernias. Read More

    EVALUATION OF EFFECTIVENESS IN A NOVEL WOUND HEALING OINTMENT-CROCODILE OIL BURN OINTMENT.
    Afr J Tradit Complement Altern Med 2017 23;14(1):62-72. Epub 2016 Nov 23.
    State Key Laboratory of Cellular Stress Biology, State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China.
    Background: Crocodile oil and its products are used as ointments for burns and scalds in traditional medicines. A new ointment formulation - crocodile oil burn ointment (COBO) was developed to provide more efficient wound healing activity. The purpose of the study was to evaluate the burn healing efficacy of this new formulation by employing deep second-degree burns in a Wistar rat model. Read More

    Guided bone regeneration with recombinant human bone morphogenetic protein 9 loaded on either deproteinized bovine bone mineral or a collagen barrier membrane.
    Clin Implant Dent Relat Res 2017 May 2. Epub 2017 May 2.
    Department of Periodontology, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida.
    Background: Recombinant human bone morphogenetic protein 9 (rhBMP9) has been considered the most osteoinductive growth factor of the BMP-family and has much translation potential for guided bone regeneration (GBR) procedures.

    Purpose: The aim of this study was to compare bone formation using rhBMP9 loaded with different carrier systems including deprotenized bovine bone mineral (BioOss, BO) or collagen barrier membranes (BioGide, BG) in a rabbit GBR model.

    Materials And Methods: rhBMP9 was loaded either on BO; named BO/BMP9, or BG; named BG/BMP9 to investigate the better carrier system for rhBMP9. Read More

    Use of Ovine-based Collagen Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressings to Help Improve Clinical Outcomes in Lower Extremity Wounds: A Retrospective Cohort Study.
    Wounds 2017 Apr;29(4):107-114
    West Boca Center for Wound Healing, Boca Raton, FL.
    Dressings that provide broad spectrum metalloprotease reduction along with inherent aspects of an extracellular matrix may contribute to improved wound healing outcomes and shorter treatment times.

    Objective: The author performed a retrospective case series analysis to determine the clinical outcomes of regular debridement with the use of ovine-based collagen extracellular matrix dressings and gentian violet/methylene blue polyurethane antibacterial foam dressings in treating 53 patients with 53 chronic lower extremity wounds (diabetic foot ulcers [DFUs], venous leg ulcers, and heel pressure ulcers).

    Materials And Methods: Patients were treated twice weekly in an outpatient clinic for the first 4 weeks and weekly thereafter until closure. Read More

    Arteriotomy Closure Devices in EVAR, TEVAR, and TAVR: A Systematic Review and Meta-analysis of Randomised Clinical Trials and Cohort Studies.
    Eur J Vasc Endovasc Surg 2017 Apr 21. Epub 2017 Apr 21.
    Department of Surgery, Division of Vascular Surgery, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
    Objectives: Cardiac and vascular surgery benefit from percutaneous interventions. Arteriotomy closure devices (ACDs) enable minimally invasive access to the common femoral artery (CFA). The objective of this review was to assess the differences between ACDs and surgical cut down (SCD) of the CFA regarding the number of complications, duration of surgery (DOS), and hospital length of stay (HLOS). Read More

    Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice.
    Sci Transl Med 2017 Apr;9(386)
    Collaborative Research Center (SFB-TR67) "Functional Biomaterials for Controlling Healing Processes in Bone and Skin-From Material Science to Clinical Application," Leipzig and Dresden, Germany.
    Excessive production of inflammatory chemokines can cause chronic inflammation and thus impair cutaneous wound healing. Capturing chemokine signals using wound dressing materials may offer powerful new treatment modalities for chronic wounds. Here, a modular hydrogel based on end-functionalized star-shaped polyethylene glycol (starPEG) and derivatives of the glycosaminoglycan (GAG) heparin was customized for maximal chemokine sequestration. Read More

    Spatiotemporal Evolution of the Wound Repairing Process in a 3D Human Dermis Equivalent.
    Adv Healthc Mater 2017 Apr 13. Epub 2017 Apr 13.
    Center for Advanced Biomaterials for HealthCare@CRIB, Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, 80125, Naples, Italy.
    Several skin equivalent models have been developed to investigate in vitro the re-epithelialization process occurring during wound healing. Although these models recapitulate closure dynamics of epithelial cells, they fail to capture how a wounded connective tissue rebuilds its 3D architecture until the evolution in a scar. Here, the in vitro tissue repair dynamics of a connective tissue is replicated by using a 3D human dermis equivalent (3D-HDE) model composed of fibroblasts embedded in their own extracellular matrix (ECM). Read More

    The Use of Acellular Urinary Bladder Matrix as Coverage for Fasciocutaneous Free Flap Donor Sites: An Alternative to Traditional Grafting Procedures.
    J Oral Maxillofac Surg 2017 Mar 18. Epub 2017 Mar 18.
    Assistant Professor, Oral and Maxillofacial Surgery, Oral, Head & Neck Oncology and Microvascular Surgery, The University of Texas Health Science Center at Houston, Houston, TX.
    Purpose: The purpose of this review is to 1) evaluate our early experience with urinary bladder matrix as a dressing for the management of complex wounds subsequent to fasciocutaneous or osteocutaneous vascularized tissue harvests, 2) assess coverage of exposed tendons and the duration of granulation and epithelial coverage, and 3) assess esthetic and functional outcomes compared with traditional means for the management of vascularized tissue harvest sites.

    Patients And Methods: This prospective study consisted of 8 consecutive patients in whom a substantial cutaneous component was harvested as part of a vascularized tissue reconstruction, which did not permit for primary closure (n = 7) or had skin graft failure (exposed tendon) that required additional treatment (n = 1).

    Results: Functional and esthetic outcomes were comparable to those of traditional methods of donor site closure as determined by clinical evaluation and subjective assessment by the patient. Read More

    Abietic acid isolated from pine resin (Resina Pini) enhances angiogenesis in HUVECs and accelerates cutaneous wound healing in mice.
    J Ethnopharmacol 2017 May 4;203:279-287. Epub 2017 Apr 4.
    College of Korean Medicine, Gachon University, Seongnam 461-701, South Korea. Electronic address:
    Ethnopharmacological Relevance: Resin known as Resina Pini is listed in the Korean and Japanese pharmacopoeias and has been used for treating skin wounds and inflammation. Resin is composed of more than 50% abietic acid and 10% neutral substances.

    Objective: In the present study, the wound-healing effects of abietic acid and the possible underlying mechanism of action were investigated in various in vitro and in vivo models. Read More

    Wound Healing Activity of Extracts and Formulations of Aloe vera, Henna, Adiantum capillus-veneris, and Myrrh on Mouse Dermal Fibroblast Cells.
    Int J Prev Med 2017 10;8:18. Epub 2017 Mar 10.
    Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Background: Among the most important factors in wound healing pathways are transforming growth factor beta1 and vascular endothelial growth factor. Fibroblasts are the main cell in all phases wound closure. In this study, the extracts of plant materials such as Adiantum capillus-veneris, Commiphora molmol, Aloe vera, and henna and one mixture of them were used to treatment of normal mouse skin fibroblasts. Read More

    Animal Bite Injuries in Children: Review of Literature and Case Series.
    Int J Clin Pediatr Dent 2017 Jan-Mar;10(1):67-72. Epub 2017 Feb 27.
    Assistant Professor,Department of Oral and Maxillofacial Surgery, Postgraduate Institute of Dental Sciences, Rohtak, Haryana, India.
    Introduction: Maxillofacial region in children is particularly vulnerable to animal bite injuries. These injuries may range from insignificant scratches to life-threatening neck and facial injuries. Children are the common victims, particularly of dog bites. Read More

    Evaluating the use of octyl-2-cyanoacrylate in unilateral cleft lip repair.
    Natl J Maxillofac Surg 2016 Jul-Dec;7(2):153-158
    Department of Oral and Maxillofacial Surgery, SGT Dental College, Gurgaon, Haryana, India.
    Background: Facial cosmetic results are one of the most concerning issues for the parents who get their children operated for cleft lip. Moreover, the postoperative care of the surgical site, the discomfort associated with the suture removal, and additional visit for suture removal are other reasons which encourages one to use any new technologies that may replace the need for suture placement. In this study, we used octyl-2-cyanoacrylate, a tissue adhesive which offers a viable alternative to traditional techniques without compromising optimal wound closure. Read More

    American Brachytherapy Society consensus statement for soft tissue sarcoma brachytherapy.
    Brachytherapy 2017 May - Jun;16(3):466-489. Epub 2017 Mar 23.
    Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
    Purpose: Radiation therapy represents an essential treatment option in the management of soft tissue sarcomas (STS). Brachytherapy represents an important subset of radiation therapy techniques used for STS, with evolving indications and applications. Therefore, the purpose of this guideline was to update clinicians regarding the data surrounding brachytherapy (BT) and provide recommendations for the utilization of BT in patients with STS. Read More

    Retrospective Evaluation of Percutaneous Access for TEVAR and EVAR: Time to Make it the Standard Approach?
    Rofo 2017 Apr 23;189(4):347-355. Epub 2017 Mar 23.
    Institute for Diagnostic and Interventional Radiology, Klinikum Oldenburg AöR, Oldenburg, Germany.
    Introduction To evaluate the safety of percutaneous endovascular aortic repair and the relationship of access site characteristics to complications Materials and Methods All patients undergoing percutaneous TEVAR, EVAR and FEVAR procedures from January 2010 to May 2016 were retrospectively analysed for incidence of complications and their relationship to various access site characteristics like access artery size, degree of vessel calcification, skin to artery distance and sheath to artery ratio. Hemostasis occurring within 15 min after suture closure with or without manual compression was defined as primary hemostasis. Results 92 patients with 142 femoral access sites were included in the study. Read More

    Cost-effective Alternative for Negative-pressure Wound Therapy.
    Plast Reconstr Surg Glob Open 2017 Feb 6;5(2):e1211. Epub 2017 Feb 6.
    Section of Plastic and Reconstructive Surgery, Department of Surgery, University of Chicago Medicine and Biological Sciences, Chicago, Ill.; and Department of Therapy Services, University of Chicago Medical Center, Chicago, Ill.
    Background: Current predominantly used equipments for negative-pressure wound therapy (NPWT) are expensive. In current healthcare climate continually emphasizing cost containment, importance in developing more cost-effective alternatives cannot be understated. Previously, therapeutically equivalent methods of providing NPWT was demonstrated using just low-cost, universally available supplies, coined Gauze-SUCtion (GSUC). Read More

    Vacuum sealing drainage as a pre-surgical adjunct in the treatment of complex (open) hand injuries: Report of 17 cases.
    Orthop Traumatol Surg Res 2017 May 6;103(3):461-464. Epub 2017 Mar 6.
    Department of Upper Extremity Orthopedics, Eastern Hospital of the First Affiliated Hospital, Sun Yat-sen University, 510080 Guang Zhou, China. Electronic address:
    Background: Few studies have been conducted to explore the use of the vacuum sealing drainage (VSD) technique in complex hand injuries. The aim of this study was to report outcomes in patients with complex hand injuries receiving VSD as a coadjuvant treatment prior to second-stage surgery.

    Methods: This case series study retrospectively reviewed the patients who underwent VSD for treatment of hand injuries. Read More

    Human Reticular Acellular Dermal Matrix in the Healing of Chronic Diabetic Foot Ulcerations that Failed Standard Conservative Treatment: A Retrospective Crossover Study.
    Wounds 2017 Feb;29(2):39-45
    Angiogenesis Foundation, Cambridge, MA.
    Background: Acellular matrices have been successfully used to heal indolent diabetic foot ulcers (DFUs). These tissues include allogenic dermis as well as xenograft dermis, pericardium, and small intestine submucosa. While all of these tissues show promise for healing DFUs, dermal-derived matrices have shown considerable potential. Read More

    Enzymatic Debridement of Chronic Nonischemic Diabetic Foot Ulcers: Results of a Randomized, Controlled Trial.
    Wounds 2017 Feb 27. Epub 2017 Feb 27.
    Smith & Nephew Inc, Fort Worth, TX andDepartment of Pediatrics, University of North Texas Health Science Center.
    Objective: The aim of this randomized, controlled multicenter trial was to evaluate the clinical outcomes associated with the use of clostridial collagenase ointment (CCO) for up to 12 weeks in 215 patients with type 1 or type 2 diabetes mellitus and a neuropathic, nonischemic diabetic foot ulcer (DFU).

    Materials And Methods: Patients were randomized into either a group receiving CCO applied once daily at a thickness of ~2 mm or a group receiving standard care (SC) consisting of a daily application of a hydrogel as needed to maintain a moist ulcer environment. All ulcers were covered with a nonadherent foam dressing that was changed once daily, and sharp debridement was allowed when the investigators deemed it medically warranted. Read More

    Vancomycin Powder Regimen for Prevention of Surgical Site Infection in Complex Spine Surgeries.
    Clin Spine Surg 2017 Mar 6. Epub 2017 Mar 6.
    *Department of Orthopedic Surgery, UT Southwestern Medical Center, Dallas, TX †Department of Orthopedic Surgery (UPMC), University of Pittsburgh Medical Center, Pittsburgh, PA ‡United States Air Force Anchorage, Anchorage, AK §Brigham and Women Hospital, Boston, MA.
    Study Design: In total, 496 patients of a single surgeon cohort examining the surgical-site infection (SSI) rates with the addition of vancomycin powder in both diabetic and revision spine surgery cases. A historical control group of 652 patients were compared from the same surgeon over an earlier time period before the inception of using vancomycin powder prophylaxis.

    Objective: The objective of this study was to describe and compare the rates of infection in high-risk patient populations while using vancomycin powder. Read More

    Incisional Hernia After Liver Transplant.
    Exp Clin Transplant 2017 Feb;15(Suppl 1):185-189
    Department of General Surgery, Baskent University, Ankara, Turkey.
    Objectives: An incisional hernia seriously burdens the quality of life after liver transplant. The incidence of incisional hernia after liver transplant is reported to be 4% to 20%. Here, we evaluated incisional hernias that occurred after adult liver transplant and incisional hernias intentionally made in infant liver transplant procedures. Read More

    Histopathological assessment of OASIS Ultra on critical-sized wound healing: a pilot study.
    J Cutan Pathol 2017 Jun 23;44(6):523-529. Epub 2017 Mar 23.
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts.
    Background: Dermatopathologists assess wounds secondary to trauma, infection, or oncologic resection that can be challenging to reconstruct. OASIS Ultra, an extracellular matrix, has been described for use in chronic and burn wounds. The aim of this pilot study is to assess wound healing in post-traumatic and infective wounds treated with OASIS using histological markers of repair. Read More

    Quantitative difference of acute intraoperative expansion in various body regions.
    Eur Rev Med Pharmacol Sci 2017 Feb;21(3):454-459
    Department of Surgical Sciences, Plastic Surgery Division, University of Parma, Parma, Italy; Cutaneous, Mini-invasive, Regenerative and Plastic Surgery Unit, Parma University Hospital, Parma, Italy.
    Objective: To investigate the efficacy of intraoperative sustained limited expansion (ISLE) by examining the ex vivo biomechanical properties of acutely expanded skin flaps.

    Materials And Methods: Fourteen fresh male cadavers were tested. On both sides of each cadaver, a 4 × 10 cm, the laterally based flap was raised at the external auditory canal of the scalp and a 15 × 8 cm, the proximately based flap was raised at the lateral arm, anterior thorax, and lateral thigh. Read More

    Cultured Human Epidermis Combined With Meshed Skin Autografts Accelerates Epithelialization and Granulation Tissue Formation in a Rat Model.
    Ann Plast Surg 2017 Jun;78(6):651-658
    From the *Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Syogoin Sakyo-ku, Kyoto; †Department of Plastic and Reconstructive Surgery, Kansai Medical University, Hirakata, Osaka; and ‡Japan Tissue Engineering, Co., Ltd., Miyakitadori, Gamagori, Aichi, Japan.
    Introduction: As the take rate of cultured epidermal autografts in burn wound treatment is variable, widely expanded meshed auto skin grafts are often used in combination with cultured epidermal autograft to increase the take rate and achieve definitive wound coverage. However, a long time (3-4 weeks) required to prepare a cultured epidermis sheet is a disadvantage. Allogeneic cultured epidermis can be prepared in advance and cryopreserved to be used in combination with auto meshed skin grafts for treating third-degree burns. Read More

    In vitro wound healing and cytotoxic activity of the gel and whole-leaf materials from selected aloe species.
    J Ethnopharmacol 2017 Mar 14;200:1-7. Epub 2017 Feb 14.
    Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address:
    Ethnopharmacological Relevance: Aloe vera is one of the most important medicinal plants in the world with applications in the cosmetic industry and also in the tonic or health drink product market. Different parts of Aloe ferox and Aloe marlothii are used as traditional medicines for different applications. Although wound healing has been shown for certain aloe gel materials (e. Read More

    Complex Ventral Hernia Repair with Acellular Dermal Matrices: Clinical and Quality of Life Outcomes.
    Am Surg 2017 Feb;83(2):141-147
    Acellular dermal matrices (ADMs) are used in conjunction with complex hernia repair, but their efficacy is often debated. This study assesses clinical and quality of life (QOL) outcomes in multiply comorbid patients undergoing complex ventral hernia repair using ADMs. After obtaining institutional review board approval, a prospective study was conducted evaluating patients undergoing complex ventral incisional hernia repair with abdominal wall reconstruction (AWR) using either human (Flex HD) or porcine ADM (Strattice). Read More

    Simple Skin-Stretching Device in Assisted Tension-Free Wound Closure.
    Ann Plast Surg 2017 Mar;78(3 Suppl 2):S52-S57
    From the *Division of Plastic Surgery, Department of Surgery, Buddhist Tzu-Chi General Hospital; †Department of Surgery, Tzu-Chi University, Hualien; and ‡Department of Surgery, Division of Plastic Surgery, Buddhist Tzu-Chi Dalin General Hospital, Chiayi, Taiwan.
    Background: Numerous conventional wound reconstruction methods, such as wound undermining with direct suture, skin graft, and flap surgery, can be used to treat large wounds. The adequate undermining of the skin flaps of a wound is a commonly used technique for achieving the closure of large tension wounds; however, the use of tension to approximate and suture the skin flaps can cause ischemic marginal necrosis. The purpose of this study is to use elastic rubber bands to relieve the tension of direct wound closure for simultaneously minimizing the risks of wound dehiscence and wound edge ischemia that lead to necrosis. Read More

    On-Demand Dissolution of Chemically Cross-Linked Hydrogels.
    Acc Chem Res 2017 Feb 7;50(2):151-160. Epub 2017 Feb 7.
    Departments of Chemistry, Biomedical Engineering, and Medicine, Boston University , 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
    The formation and subsequent on-demand dissolution of chemically cross-linked hydrogels is of keen interest to chemists, engineers, and clinicians. In this Account, we summarize our recent advances in the area of dissolvable chemically cross-linked hydrogels and provide a comparative discussion of other recent hydrogel systems. Using biocompatible macromonomers, we developed a library of cross-linked dendritic hydrogels that possess favorable properties, including biocompatibility, tissue adhesion, and swelling. Read More

    Use of locking barbed sutures in foot and ankle surgery. A case series.
    Foot Ankle Surg 2017 Mar 23;23(1):57-61. Epub 2016 Apr 23.
    Netcare Linksfield Orthopaedic Sports & Rehabilitation Centre (Clinic), Johannesburg, South Africa; Orthopaedic Department, University of the Witwatersrand, Johannesburg, South Africa.
    Background: Barbed sutures represent a novel technique for wound closure. By distributing tension forces across the length of a wound, it results in better wound healing. A recent article from Chowdhry et al. Read More

    The suture pullout characteristics of human and porcine linea alba.
    J Mech Behav Biomed Mater 2017 Apr 24;68:103-114. Epub 2017 Jan 24.
    Trinity Centre for Bioengineering, Department of Mechanical and Manufacturing Engineering, Parsons Building, Trinity College, College Green, Dublin 2, Ireland. Electronic address:
    There is a substantial prevalence of post-operative incisional hernia for both laparoscopic and laparotomy procedures, but there have been few attempts at quantifying abdominal wound closure methodology in the literature. One method to ascertain a more robust method of wound closure is the identification of the influence of suture placement parameters on suture pullout force. Current surgical practice involves a recommended bite depth and bite separation of 10mm, but the evidence base for this is not clear. Read More

    Use of a Dehydrated Amniotic Membrane Allograft in the Treatment of Lower Extremity Wounds: A Retrospective Cohort Study.
    Wounds 2017 Jan 23. Epub 2017 Jan 23.
    West Boca Center for Wound Healing, Boca Raton, FL.
    Injuries to the skin are extensively costly to the health care system. When caused by metabolic and vascular compromise, these injuries are even more foreboding for patients. They can result in chronic inflammation, reduced mobility, and chronic pain. Read More

    Novel human bioactive peptides identified in Apolipoprotein B: Evaluation of their therapeutic potential.
    Biochem Pharmacol 2017 Apr 25;130:34-50. Epub 2017 Jan 25.
    Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy; Istituto Nazionale di Biostrutture e Biosistemi (INBB), Italy. Electronic address:
    Host defence peptides (HDPs) are short, cationic amphipathic peptides that play a key role in the response to infection and inflammation in all complex life forms. It is increasingly emerging that HDPs generally have a modest direct activity against a broad range of microorganisms, and that their anti-infective properties are mainly due to their ability to modulate the immune response. Here, we report the recombinant production and characterization of two novel HDPs identified in human Apolipoprotein B (residues 887-922) by using a bioinformatics method recently developed by our group. Read More

    IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice.
    PLoS One 2017 26;12(1):e0170639. Epub 2017 Jan 26.
    Department of Immunology, Genentech, South San Francisco, California, United States of America.
    Diabetic foot ulcers (DFU) are one of the major complications in type II diabetes patients and can result in amputation and morbidity. Although multiple approaches are used clinically to help wound closure, many patients still lack adequate treatment. Here we show that IL-20 subfamily cytokines are upregulated during normal wound healing. Read More

    Addressing Unmet Clinical Needs with UV Bioadhesives.
    Biomacromolecules 2017 Mar 20;18(3):674-682. Epub 2017 Feb 20.
    School of Materials Science and Engineering, Nanyang Technological University , Block N4.1, Nanyang Avenue, Singapore 639798.
    The invasive practice of suturing for wound closure has persisted for millennia; with the rate of medical development, it is staggering that there are few viable alternatives to invasive mechanical fasteners. Biocompatible and biodegradable polymers are attractive candidates for versatile bioadhesives and could revolutionize surgical procedures. Bioadhesives can be broadly placed into two groups: activated and instant. Read More

    One - staged reconstruction of bladder exstrophy in male patients: long - term follow-up outcomes.
    Int Braz J Urol 2017 Jan-Feb;43(1):155-162
    Divisão de Urologia do Departamento de Cirurgia, Universidade de São Paulo, SP, Brasil.
    Introduction: The surgical correction of bladder exstrophy remains challenging. In our institution, the repair has evolved from a staged repair to one-stage reconstruction. The one-stage reconstruction includes; bladder closure, Cantwell-Ransley neourethroplasty and abdominoplasty using groin flaps, without the need of pelvic ostheotomies. Read More

    Experimental study on tissue phantoms to understand the effect of injury and suturing on human skin mechanical properties.
    Proc Inst Mech Eng H 2017 Jan 21;231(1):80-91. Epub 2016 Dec 21.
    3 Department of Biological Sciences, University of Alabama, Tuscaloosa, AL, USA.
    Skin injuries are the most common type of injuries occurring in day-to-day life. A skin injury usually manifests itself in the form of a wound or a cut. While a shallow wound may heal by itself within a short time, deep wounds require surgical interventions such as suturing for timely healing. Read More

    Accelerated Wound Closure - Differently Organized Nanofibers Affect Cell Migration and Hence the Closure of Artificial Wounds in a Cell Based In Vitro Model.
    PLoS One 2017 6;12(1):e0169419. Epub 2017 Jan 6.
    Dept. Biology, Unit of Functional Zoology, Bio-interface Group, Lund University, Lund, Sweden.
    Nanofiber meshes holds great promise in wound healing applications by mimicking the topography of extracellular matrix, hence providing guidance for crucial cells involved in the regenerative processes. Here we explored the influence of nanofiber alignment on fibroblast behavior in a novel in vitro wound model. The model included electrospun poly-ε-caprolactone scaffolds with different nanofiber orientation. Read More

    Hydroxyapatite cement cranioplasty following translabyrinthine approach: Long-term study of 369 cases.
    Laryngoscope 2017 Jan 6. Epub 2017 Jan 6.
    Department of Otolaryngology, Baton Rouge, Louisiana.
    Objective: To report the authors' experience with hydroxyapatite cement (HAC) cranioplasty and analyze the material's long-term safety and efficacy in repairing translabyrinthine skull-base defects by examining adverse events, specifically cerebrospinal fluid (CSF) leaks and surgical site infections.

    Study Design: Retrospective case-control study (primary study arm); prospective cross-sectional study of patients not examined within the last 5 years (secondary arm).

    Setting: tertiary-care neurotology private practice and academic practice (two centers). Read More

    Biocompatibility study of lithium disilicate and zirconium oxide ceramics for esthetic dental abutments.
    J Periodontal Implant Sci 2016 Dec 27;46(6):362-371. Epub 2016 Dec 27.
    Laboratory of Biomechanics and Bioengineering, Research Center of Royallieu, University of Technology of Compiègne, Sorbonne Universities, Compiègne, France.; Tufts University School of Dental Medicine, Boston, MA, USA.
    Purpose: The increasing demand for esthetically pleasing results has contributed to the use of ceramics for dental implant abutments. The aim of this study was to compare the biological response of epithelial tissue cultivated on lithium disilicate (LS2) and zirconium oxide (ZrO2) ceramics. Understanding the relevant physicochemical and mechanical properties of these ceramics will help identify the optimal material for facilitating gingival wound closure. Read More

    Exendin-4, a glucagon-like peptide-1 analogue, accelerates diabetic wound healing.
    J Surg Res 2017 Feb 17;208:93-103. Epub 2016 Sep 17.
    Department of Anesthesiology, Buddhist Tzu-Chi General Hospital and Tzu-Chi University School of Medicine, Hualien, Taiwan; Department of Anesthesiology, Taipei Medical University Hospital and School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:
    Background: Diabetes disregulates inflammatory responses and impairs vascular function in wounds. Glucagon-like peptide-1 receptor (Glp-1R) agonists are hypoglycemic agents with pleiotropic vascular protective and anti-inflammatory effects. The therapeutic potential of a Glp-1 analogue in a diabetic rat model of excisional wound injury was investigated. Read More

    Adhesion and metabolic activity of human corneal cells on PCL based nanofiber matrices.
    Mater Sci Eng C Mater Biol Appl 2017 Feb 26;71:764-770. Epub 2016 Oct 26.
    Department of Ophthalmology, Universität Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany. Electronic address:
    In this work, polycaprolactone (PCL) was used as a basic polymer for electrospinning of random and aligned nanofiber matrices. Our aim was to develop a biocompatible substrate for ophthalmological application to improve wound closure in defects of the cornea as replacement for human amniotic membrane. We investigated whether blending the hydrophobic PCL with poly (glycerol sebacate) (PGS) or chitosan (CHI) improves the biocompatibility of the matrices for cell expansion. Read More

    Silicon-dioxide-polyvinylpyrrolidone as a wound dressing for skin defects in a murine model.
    J Craniomaxillofac Surg 2017 Jan 15;45(1):99-107. Epub 2016 Oct 15.
    Department of Oral & Maxillofacial Plastic Surgery (Head: Frerich, Bernhard), University Medical Centre of Rostock, Schillingallee 35, 18057 Rostock, Germany. Electronic address:
    Objective: There is a high demand for temporary wound dressings that improve wound healing and regeneration. Silicon (as SiO2) has been shown to support the growth and collagen formation in biological systems.

    Methods: A nanocomposite was made from PVP (polyvinylpyrrolidon), nano-sized silica aggregates and water and served for fabrication of a wet dressing material (SiO2-PVP gel, by cross-linking the gel) and a freeze-dried dressing material (SiO2-PVP fleece). Read More

    Topical vanadate enhances the repair of median laparotomy incisions.
    J Surg Res 2017 Jan 31;207:102-107. Epub 2016 Aug 31.
    Department of Surgery, Penn State Hershey Medical Center, Hershey, Pennsylvania.
    Background: There are over two million laparotomies performed in the United States each year with an incisional hernia rate between 2% and 11%. A total of 100,000 ventral hernia repairs are undertaken each year with recurrences as high as 50%.

    Materials And Methods: Full thickness midline fascia incisions from the xiphoid to the pubic symphysis were made in rats. Read More

    [A Case Report of Spontaneous Cerebrospinal Fluid Otorrhea].
    No Shinkei Geka 2016 Dec;44(12):1053-1057
    Department of Neurosurgery, Atami Tokoro Memorial Hospital.
    Spontaneous cerebrospinal fluid(CSF)otorrhea is less common than CSF leakage caused by trauma, and rarely occurs in adults. We report an adult case of CSF otorrhea. A 71-year-old woman with no traumatic or otologic history was hospitalized due to bacterial meningitis. Read More

    Surgical site infection in tibial plateau fractures with ipsilateral compartment syndrome.
    Injury 2017 Feb 18;48(2):495-500. Epub 2016 Oct 18.
    R Adams Cowley Shock Trauma Center, Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:
    Aim: The aim of this study was to investigate the effects of compartment syndrome and timing of fasciotomy wound closure on surgical site infection (SSI) after surgical fixation of tibial plateau fractures. Our primary hypothesis was that SSI rate is increased for fractures with compartment syndrome versus those without, even accounting for confounders associated with infection. Our secondary hypothesis was that infection rates are unrelated to timing of fasciotomy closure or fixation. Read More

    The Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR) Procedure: An Early Feasibility Cohort Study.
    Orthop J Sports Med 2016 Nov 21;4(11):2325967116672176. Epub 2016 Nov 21.
    Division of Sports Medicine, Department of Orthopaedic Surgery, Boston Children's Hospital Boston, Massachusetts, USA.
    Background: This study assessed the safety of the newly developed bridge-enhanced anterior cruciate ligament (ACL) repair (BEAR), which involves suture repair of the ligament combined with a bioactive scaffold to bridge the gap between the torn ligament ends. As the intra-articular environment is complex in its response to implanted materials, this study was designed to determine whether there would be a significant rate of adverse reaction to the implanted scaffold.

    Hypothesis: The primary hypothesis was that the implanted scaffold would not result in a deep joint infection (arthrocentesis with positive culture) or significant inflammation (clinical symptoms justifying arthrocentesis but negative culture). Read More

    Flap Designs for Flap Advancement During Implant Therapy: A Systematic Review.
    Implant Dent 2017 Feb;26(1):145-152
    *Resident, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI. †Professor and Director of Graduate Periodontics, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI.
    Purpose: Guided bone regeneration (GBR) procedures allow ridge augmentation before or at time of implant placement. GBR outcomes rely on primary passive tension-free wound closure, which may be achieved by a variety of flap designs and surgical procedures. A comprehensive literature review of flap design and management is provided, including material types, incision design, reflection, releasing, and suturing techniques. Read More

    The effect of local hyperglycemia on skin cells in vitro and on wound healing in euglycemic rats.
    J Surg Res 2016 Dec 24;206(2):418-426. Epub 2016 Aug 24.
    Division of Plastic Surgery, Department of Surgery, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:
    Background: Multiple previous studies have established that high systemic blood glucose concentration impairs skin wound healing. However, the effects of local hyperglycemia on wound healing are not well defined. Comprehensive animal studies and in vitro studies using both fibroblasts and keratinocytes are lacking. Read More

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