2,824 results match your criteria Materials for Wound Closure

Study of the Effect of Photobiomodulation on a Skin Repair Model in SKH-1 Mice.

Photobiomodul Photomed Laser Surg 2022 May;40(5):325-333

Department of Dermatology, Stomatology, Radiology and Physic Medicine, Faculty of Medicine, Campus of Excellence Mare Nostrum, University of Murcia, Murcia, Spain.

Laser applied at low power (400-1100 nm), currently named photobiomodulation (PBM), is a noninvasive therapy to speed up wound healing. The purpose of this study was whether two different laser PBM delivery protocols would impact the skin wound healing in a mouse model. A total of 24 SKH-1 mice were divided into three groups: Group 1 (control: untreated ulcers), Group 2 (a single postsurgical laser application), and Group 3 (laser each other day for 10 days; total five applications). Read More

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A tough synthetic hydrogel with excellent post-loading of drugs for promoting the healing of infected wounds in vivo.

Mater Sci Eng C Mater Biol Appl 2021 Nov 29:112577. Epub 2021 Nov 29.

College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China; Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan 030000, China; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address:

Bacterial infection is a major obstacle to the wound healing process. The hydrogel dressings with a simpler structure and good antibacterial and wound healing performance are appealing for clinical application. Herein, a robust hydrogel was synthesized from acrylamide (AM), acrylic acid (AA) and N,N'-methylene diacrylamide (MBA) via a redox initiating polymerization. Read More

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November 2021

Polyhexamethylene guanidine hydrochloride modified sodium alginate nonwoven with potent antibacterial and hemostatic properties for infected full-thickness wound healing.

Int J Biol Macromol 2022 Apr 29. Epub 2022 Apr 29.

College of Biomass Science and Engineering, Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China; Yibin Institute of Industrial Technology, Sichuan University, Research Center for Fiber Science and Engineering Technology, Yibin Park, Yibin 64460, China; State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China. Electronic address:

The development of multifunctional wound dressings has always been considered as a promising strategy to promote blood coagulation, inhibit bacterial infection, and accelerate wound healing. Herein, an antibacterial and hemostatic dressing (SA-PHMG) was developed based on sodium alginate (SA) nonwoven and polyhexamethylene guanidine hydrochloride (PHMG) through a completely green industrial route, including dipping, padding, and drying. According to studies, SA-PHMG dressings exhibited excellent liquid absorption capacity and water vapor permeability. Read More

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Povidone-iodine irrigation reduces infection after total hip and knee arthroplasty.

Arch Orthop Trauma Surg 2022 Apr 30. Epub 2022 Apr 30.

Division of Orthopaedic Surgery, McGill University, Montreal, QC, Canada.

Introduction: One of the most important challenges faced by orthopedic surgeons is periprosthetic joint infection (PJI). PJI is a common cause for total joint arthroplasty failure with an incidence of 0.3-1. Read More

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Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing.

Biomaterials 2022 Apr 14;285:121479. Epub 2022 Apr 14.

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA; Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address:

Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. Read More

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Alginate/polycaprolactone composite fibers as multifunctional wound dressings.

Carbohydr Polym 2022 Aug 4;289:119440. Epub 2022 Apr 4.

Department of Chemical and Materials Engineering, National Central University, Taoyuan City, Taiwan.

We developed a composite wound dressing that provides multifunctional wound care. Alginate and polycaprolactone (PCL) were coelectrospun as composite fibers. Highly absorbent alginate provided a moist environment for wounds and PCL increased cell adhesion. Read More

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Ruyi Jinhuang Powder accelerated diabetic ulcer wound healing by regulating Wnt/β-catenin signaling pathway of fibroblasts In Vivo and In Vitro.

J Ethnopharmacol 2022 Jul 26;293:115321. Epub 2022 Apr 26.

Department of Dermatology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, China. Electronic address:

Ethnopharmacological Relevance: Diabetic ulcer is a common complication of diabetes. Therapies of diabetic ulcer are still challenging due to the complicated aetiology. Ruyi Jinhuang Powder (RJP) is gradually adopted to treat diabetic ulcer and has a significant therapeutic effect. Read More

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Contact Dermatitis in the Surgical Patient: A Focus on Wound Closure Materials.

Dermatitis 2022 Apr 28. Epub 2022 Apr 28.

The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, NY.

Abstract: Irritant and allergic contact dermatitis from wound closure materials can occur in patients after surgical procedures. The resulting inflammation from contact dermatitis can compromise wound healing, mimic surgical site infections, and result in wound dehiscence. Components of wound closure material, such as antibiotic coatings, dyes, sterilizing compounds, or the material itself, have been implicated as contact allergens. Read More

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NeoPep S: A New Generation of AIMP1-derived Peptide (AdP) Effects on Wound Healing .

In Vivo 2022 May-Jun;36(3):1222-1235

Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea;

Background/aim: The skin plays an important role in protecting the body from mechanical damage, microbial infection, ultraviolet radiation, and extreme temperatures. Many products as well as ongoing studies have focused on skin injury and repair; however, unlimited challenges are still being faced. Furthermore, the drugs that are currently on the market are not adequate to meet the increasing medical needs. Read More

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Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management.

J Mater Chem B 2022 Apr 27. Epub 2022 Apr 27.

Research Institute for Biomaterials, Tech Institute for Advanced Materials, College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211816, China.

Due to their inherent and tunable biomechanical and biochemical performances, bioactive hydrogels based on polysaccharides and peptides have shown attractive potential for wound management. In this review, the recent progress of bioactive hydrogels prepared by polysaccharides and peptides for soft tissue wound management is overviewed. Meanwhile, we focus on the elaboration of the relationship between chemical structures and inherent bioactive functions of polysaccharides and peptides, as well as the strategies that are taken for achieving multiple wound repairing effects including hemostasis, adhesion, wound contraction and closure, anti-bacteria, anti-oxidation, immunomodulation, molecule delivery, Some innovative and important works are well introduced as well. Read More

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Clinical Evaluation of Lateral Pedicle Flap Stabilized with Cyanoacrylate Tissue Adhesive: A Randomized Controlled Clinical Trial.

Contemp Clin Dent 2022 Jan-Mar;13(1):24-29. Epub 2022 Mar 23.

Department of Periodontics, Best Dental Science College, Madurai, Tamil Nadu, India.

Context: Gingival recession is the most common mucogingival defect and is susceptible to tooth hypersensitivity, root caries, and esthetic problems if left untreated. A lateral pedicle flap is used to cover denuded roots that have adequate donor tissue laterally and adequate vestibular depth. A carefully planned surgery needs proper immobilization of the flap at the recipient site and this can be achieved by proper wound closure technique with appropriate material such as sutures or tissue adhesives. Read More

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Catalyst-Free Click Chemistry for Engineering Chondroitin Sulfate-Multiarmed PEG Hydrogels for Skin Tissue Engineering.

J Funct Biomater 2022 Apr 18;13(2). Epub 2022 Apr 18.

LIMAV-Interdisciplinary Laboratory for Advanced Materials, BioMatLab, Materials Science & Engineering Graduate Program, UFPI-Federal University of Piauí, Teresina 64049-550, PI, Brazil.

The quest for an ideal biomaterial perfectly matching the microenvironment of the surrounding tissues and cells is an endless challenge within biomedical research, in addition to integrating this with a facile and sustainable technology for its preparation. Engineering hydrogels through click chemistry would promote the sustainable invention of tailor-made hydrogels. Herein, we disclose a versatile and facile catalyst-free click chemistry for the generation of an innovative hydrogel by combining chondroitin sulfate (CS) and polyethylene glycol (PEG). Read More

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Wound healing activity of the hydroalcoholic extract and the main metabolites of Amphipterygium adstringens (cuachalalate) in a rat excision model.

J Ethnopharmacol 2022 Jul 22;293:115313. Epub 2022 Apr 22.

Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria Coyoacán, 04510, Ciudad de México, Mexico. Electronic address:

Ethnopharmacological Relevance: The bark of Amphipterygium adstringens Schiede ex Schltdl (Anacardiaceae), commonly known as 'cuachalalate' has been used in Mexican traditional medicine for the treatment of skin and oral lesions, gastric ulcers, and other conditions. The use as wound healing of the bark of this plant has been known since before the Spanish conquest of Mexico. Its uses are mentioned in the first writings of the Spanish in the 16th century. Read More

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Performance of biodegradable temporizing matrix vs collagen-chondroitin silicone bilayer dermal regeneration substitutes in soft tissue wound healing: a retrospective analysis.

Wounds 2022 Apr;34(4):106-115

Case Western Reserve University School of Medicine, Cleveland, Ohio.

Introduction: This study compared outcomes of soft tissue reconstruction using biodegradable temporizing matrix (BTM) and collagen-chondroitin silicone (CCS) skin substitutes.

Objective: In this study, the authors compared wound healing rates and complication rates between BTM and CCS.

Materials And Methods: This retrospective study reviewed outcomes for adult patients who underwent soft tissue reconstruction with either BTM or CCS skin substitutes between 2015 and 2020. Read More

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Hydrogel assisted synthesis of gold nanoparticles with enhanced microbicidal and in vivo wound healing potential.

Sci Rep 2022 Apr 21;12(1):6575. Epub 2022 Apr 21.

Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.

The present study reports a hydrogel-based sunlight-assisted synthesis of gold nanoparticles (Au NPs) with enhanced antimicrobial and wound healing potential. The hydrogel extracted from the seeds of Cydonia oblonga was used as a reducing and capping agent to synthesize Au NPs for the first time. The as-synthesized Au NPs were characterized for an average size, shape, surface functionalization, antimicrobial, and wound healing capabilities. Read More

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Supramolecular Thermo-Contracting Adhesive Hydrogel with Self-Removability Simultaneously Enhancing Noninvasive Wound Closure and MRSA-Infected Wound Healing.

Adv Healthc Mater 2022 Apr 15:e2102749. Epub 2022 Apr 15.

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, China.

Conventional wound closure and dressing are two crucial, time-consuming but isolated principles in wound care. Even though tissue adhesive opens a new era for wound closure, the method and biomaterial that can simultaneously achieve noninvasive wound closure and promote wound healing are highly appreciated. Herein, a novel supramolecular poly(N-isopropylacrylamide) hybrid hydrogel dressing composed of quaternized chitosan-graft-β-cyclodextrin, adenine, and polypyrrole nanotubes via host-guest interaction and hydrogen bonds is developed. Read More

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Wound healing in second-degree burns in rats treated with silver sulfadiazine: a systematic review and meta-analysis.

J Wound Care 2022 Apr;31(Sup4):S31-S45

Biological Materials Laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai, India.

Objective: This study aims to assess the wound healing efficacy in second-degree burns in rats treated with 1% silver sulfadiazine (SSD)-a sulfonamide antibiotic.

Method: This is a systematic literature review and meta-analysis performed according to the PICO (Population, Intervention, Comparison and Outcomes) strategy.

Results: The review found 100 studies in PubMed, Web of Science and other search engines. Read More

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Wound healing activity of -based topical formulations in mice.

Vet World 2022 Feb 19;15(2):390-396. Epub 2022 Feb 19.

Department of Physiology, School of Medicine, National University of Trujillo, Trujillo, Perú.

Background And Aim: Ruiz and Pavón, a tuber native to South America, is characterized by its antioxidant, antimicrobial, and anti-inflammatory properties that contribute to wound healing. This study aimed to evaluate the healing effect of the topical formulations (gel and cream) on induced wounds in mice.

Materials And Methods: Here, an acidic ethanolic extract (1. Read More

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February 2022

pH-Switchable Antimicrobial Supramolecular Hydrogels for Synergistically Eliminating Biofilm and Promoting Wound Healing.

ACS Appl Mater Interfaces 2022 Apr 8;14(16):18120-18132. Epub 2022 Apr 8.

College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China.

Biofilm infection will cause chronic inflammation and hinder the normal healing process of wound. Here, based on the self-assembly of three designed amphiphilic pentapeptides named EK, GG, and DR, pH-switchable antibacterial hydrogels with amphiphilic fiber network are used for the eradication of biofilms and the rescue of delayed healing in infected wounds. These pentapeptides-based hydrogels exhibit an acidic pH-switchable antimicrobial effect and are biocompatible at neutral pH. Read More

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Improved mechanical, degradation, and biological performances of Zn-Fe alloys as bioresorbable implants.

Bioact Mater 2022 Nov 30;17:334-343. Epub 2021 Dec 30.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.

Zinc (Zn) is a promising bioresorbable implant material with more moderate degradation rate compared to magnesium (Mg) and iron (Fe). However, the low mechanical strength and localized degradation behavior of pure Zn limit its clinical applications. Alloying is one of the most effective ways to overcome these limitations. Read More

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November 2022

Alloyed nanostructures integrated metal-phenolic nanoplatform for synergistic wound disinfection and revascularization.

Bioact Mater 2022 Oct 19;16:95-106. Epub 2022 Mar 19.

College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan, 610065, China.

New materials for combating bacteria-caused infection and promoting the formation of microvascular networks during wound healing are of vital importance. Although antibiotics can be used to prevent infection, treatments that can disinfect and accelerate wound healing are scarce. Herein, we engineer a coating that is both highly compatible with current wound dressing substrates and capable of simultaneously disinfecting and revascularizing wounds using a metal-phenolic nanoplatform containing an alloyed nanostructured architecture ([email protected]). Read More

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October 2022

Foot and Ankle Surgical Incision Closure With Three Different Materials.

J Foot Ankle Surg 2021 Nov 29. Epub 2021 Nov 29.

Department of Orthopedic Surgery, Hannover Medical School, Hannover, Germany.

There is no clear recommendation for wound closure material in foot and ankle surgery. Thus, we hypothesized that there was no difference in clinical outcomes among 3 suture materials, namely, absorbable sutures, nonabsorbable sutures, and metallic staples. This study compared the 3 materials for wound closure in foot and ankle surgery. Read More

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November 2021

A silk fibroin based bioadhesive with synergistic photothermal-reinforced antibacterial activity.

Int J Biol Macromol 2022 Jun 30;209(Pt A):608-617. Epub 2022 Mar 30.

College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610065, China.; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610065, China.; Med-X Center for Materials, Sichuan University, Chengdu 610041, China.

Bioadhesives have gained considerable popularity for application in wound closure. However, applying bioadhesives incurs risks associated with bacterial infection during wound healing. Hence, in this study, a silk fibroin based bioadhesive was constructed via employing natural macromolecule, silk fibroin (SF), to spontaneously coassemble with natural plant polyphenol, tannic acid (TA), and iron oxide nanoparticles (FeO NPs). Read More

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Chitosan/PVA Hetero-Composite Hydrogel Containing Antimicrobials, Perfluorocarbon Nanoemulsions, and Growth Factor-Loaded Nanoparticles as a Multifunctional Dressing for Diabetic Wound Healing: Synthesis, Characterization, and In Vitro/In Vivo Evaluation.

Pharmaceutics 2022 Feb 28;14(3). Epub 2022 Feb 28.

Department of Biomedical Sciences and Engineering, National Central University, Taoyuan City 32001, Taiwan.

Diabetic foot ulcers remain one of the most difficult-to-treat complications of diabetes and may seriously threaten the life of patients since it frequently results in limb loss due to amputation, suggesting that an effective therapeutic strategy is still urgently needed. In this study, a chitosan-based heterogeneous composite hydrogel encapsulating perfluorocarbon emulsions, epidermal growth factor (EGF)-loaded chitosan nanoparticles, and polyhexamethylene biguanide (PHMB) named PEPCH was developed for diabetic wound healing. The PEPCH could sustainably release EGF and PHMB in an ion-rich environment to exert antibacterial effects and promote cell growth for wound repair. Read More

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February 2022

A Dual-Cross-Linked Hydrogel Patch for Promoting Diabetic Wound Healing.

Small 2022 Apr 23;18(17):e2106172. Epub 2022 Mar 23.

School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Diabetic wound treatment faces significant challenges in clinical settings. Alternative treatment approaches are needed. Continuous bleeding, disordered inflammatory regulation, obstruction of cell proliferation, and disturbance of tissue remodeling are the main characteristics of diabetic wound healing. Read More

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The Origin and Development of Interrupted Subcuticular Suture: An Important Technique for Achieving Optimum Wound Closure.

Dermatol Surg 2022 Mar 21. Epub 2022 Mar 21.

All authors are affiliated with the Department of Plastic Surgery, Peking Union Medical College Hospital.

Background: Subcuticular suture is an important technique for achieving optimum wound closure, and there has been no comprehensive summary of subcuticular sutures to date.

Objective: To summarize the origin and development of interrupted subcuticular suture to help clinicians improve their wound closure skills.

Materials And Methods: A comprehensive review of subcuticular suture techniques was conducted in PubMed to summarize the advantages and disadvantages of various methods and clinical indications. Read More

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A Biodegradable Multifunctional Film as a Tissue Adhesive for Instant Hemostasis and Wound Closure.

Macromol Rapid Commun 2022 May 1;43(9):e2200031. Epub 2022 Apr 1.

College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.

Here, a multifunctional film (MFF) as an alternative tissue adhesive in the form of an interpenetrating network consisting of self-crosslinked aldehyde-functionalized chitosan (AC) and crosslinked poly(acrylic acid) (PAA) further coordinated with Ag is reported. The MFF combines enhanced toughness and stretchability, which is attributed to the synergistic effects of the double-network design. Covalent crosslinking maintains the overall integrity of the MFF matrix, while noncovalent crosslinking dissipates energy under deformation. Read More

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Nitric oxide-releasing biomaterials for promoting wound healing in impaired diabetic wounds: State of the art and recent trends.

Biomed Pharmacother 2022 May 15;149:112707. Epub 2022 Mar 15.

Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha 2713, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713, Doha, Qatar. Electronic address:

Impaired diabetic wounds are serious pathophysiological complications associated with persistent microbial infections including failure in the closure of wounds, and the cause of a high frequency of lower limb amputations. The healing of diabetic wounds is attenuated due to the lack of secretion of growth factors, prolonged inflammation, and/or inhibition of angiogenic activity. Diabetic wound healing can be enhanced by supplying nitric oxide (NO) endogenously or exogenously. Read More

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PLGA Nanoparticle Rapamycin- or Necrostatin-1-Coated Sutures Inhibit Inflammatory Reactions after Arterial Closure in Rats.

ACS Appl Bio Mater 2022 Apr 17;5(4):1501-1507. Epub 2022 Mar 17.

Department of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan 450052, China.

: The inflammatory reaction of sutures and oozing after arterial closure depends on the suture material and the amount of oozing surrounding the sutures. Anti-inflammation coatings have been proven to be an effective strategy to decrease this reaction. The aim of this study was to establish an arterial closure oozing model in rats and to test the effect of poly (lactic--glycolic acid) (PLGA) nanoparticle (NP) rapamycin- or necrostatin-1(NEC-1)-coated sutures on the inflammatory reaction after arterial closure. Read More

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MXene-Enhanced Chitin Composite Sponges with Antibacterial and Hemostatic Activity for Wound Healing.

Adv Healthc Mater 2022 Mar 14:e2102367. Epub 2022 Mar 14.

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, China.

This study shows the effective use of MXene-based nanomaterials to improve the performance of biocomposite sponges in wound healing. In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds. With the addition of MXene-based nanomaterials, the hemostatic efficacy of CH is enhanced due to the improved hemophilicity and accelerated blood coagulation kinetics. Read More

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