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    1665 results match your criteria Materials for Wound Closure

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    Simple Skin-Stretching Device in Assisted Tension-Free Wound Closure.
    Ann Plast Surg 2017 Feb 14. Epub 2017 Feb 14.
    From the *Division of Plastic Surgery, Department of Surgery, Buddhist Tzu-Chi General Hospital; †Department of Surgery, Tzu-Chi University, Hualien; and ‡Department of Surgery, Division of Plastic Surgery, Buddhist Tzu-Chi Dalin General Hospital, Chiayi, Taiwan.
    Background: Numerous conventional wound reconstruction methods, such as wound undermining with direct suture, skin graft, and flap surgery, can be used to treat large wounds. The adequate undermining of the skin flaps of a wound is a commonly used technique for achieving the closure of large tension wounds; however, the use of tension to approximate and suture the skin flaps can cause ischemic marginal necrosis. The purpose of this study is to use elastic rubber bands to relieve the tension of direct wound closure for simultaneously minimizing the risks of wound dehiscence and wound edge ischemia that lead to necrosis. Read More

    On-Demand Dissolution of Chemically Cross-Linked Hydrogels.
    Acc Chem Res 2017 Feb 7. Epub 2017 Feb 7.
    Departments of Chemistry, Biomedical Engineering, and Medicine, Boston University , 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
    The formation and subsequent on-demand dissolution of chemically cross-linked hydrogels is of keen interest to chemists, engineers, and clinicians. In this Account, we summarize our recent advances in the area of dissolvable chemically cross-linked hydrogels and provide a comparative discussion of other recent hydrogel systems. Using biocompatible macromonomers, we developed a library of cross-linked dendritic hydrogels that possess favorable properties, including biocompatibility, tissue adhesion, and swelling. Read More

    Use of locking barbed sutures in foot and ankle surgery. A case series.
    Foot Ankle Surg 2017 Mar 23;23(1):57-61. Epub 2016 Apr 23.
    Netcare Linksfield Orthopaedic Sports & Rehabilitation Centre (Clinic), Johannesburg, South Africa; Orthopaedic Department, University of the Witwatersrand, Johannesburg, South Africa.
    Background: Barbed sutures represent a novel technique for wound closure. By distributing tension forces across the length of a wound, it results in better wound healing. A recent article from Chowdhry et al. Read More

    The suture pullout characteristics of human and porcine linea alba.
    J Mech Behav Biomed Mater 2017 Jan 24;68:103-114. Epub 2017 Jan 24.
    Trinity Centre for Bioengineering, Department of Mechanical and Manufacturing Engineering, Parsons Building, Trinity College, College Green, Dublin 2, Ireland. Electronic address:
    There is a substantial prevalence of post-operative incisional hernia for both laparoscopic and laparotomy procedures, but there have been few attempts at quantifying abdominal wound closure methodology in the literature. One method to ascertain a more robust method of wound closure is the identification of the influence of suture placement parameters on suture pullout force. Current surgical practice involves a recommended bite depth and bite separation of 10mm, but the evidence base for this is not clear. Read More

    Use of a Dehydrated Amniotic Membrane Allograft in the Treatment of Lower Extremity Wounds: A Retrospective Cohort Study.
    Wounds 2017 Jan 23. Epub 2017 Jan 23.
    West Boca Center for Wound Healing, Boca Raton, FL.
    Injuries to the skin are extensively costly to the health care system. When caused by metabolic and vascular compromise, these injuries are even more foreboding for patients. They can result in chronic inflammation, reduced mobility, and chronic pain. Read More

    Novel human bioactive peptides identified in Apolipoprotein B: Evaluation of their therapeutic potential.
    Biochem Pharmacol 2017 Jan 25. Epub 2017 Jan 25.
    Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy; Istituto Nazionale di Biostrutture e Biosistemi (INBB), Italy. Electronic address:
    Host defence peptides (HDPs) are short, cationic amphipathic peptides that play a key role in the response to infection and inflammation in all complex life forms. It is increasingly emerging that HDPs generally have a modest direct activity against a broad range of microorganisms, and that their anti-infective properties are mainly due to their ability to modulate the immune response. Here, we report the recombinant production and characterization of two novel HDPs identified in human Apolipoprotein B (residues 887-922) by using a bioinformatics method recently developed by our group. Read More

    One - staged reconstruction of bladder exstrophy in male patients: long - term follow-up outcomes.
    Int Braz J Urol 2017 Jan-Feb;43(1):155-162
    Divisão de Urologia do Departamento de Cirurgia, Universidade de São Paulo, SP, Brasil.
    Introduction: The surgical correction of bladder exstrophy remains challenging. In our institution, the repair has evolved from a staged repair to one-stage reconstruction. The one-stage reconstruction includes; bladder closure, Cantwell-Ransley neourethroplasty and abdominoplasty using groin flaps, without the need of pelvic ostheotomies. Read More

    Experimental study on tissue phantoms to understand the effect of injury and suturing on human skin mechanical properties.
    Proc Inst Mech Eng H 2017 Jan 21;231(1):80-91. Epub 2016 Dec 21.
    3 Department of Biological Sciences, University of Alabama, Tuscaloosa, AL, USA.
    Skin injuries are the most common type of injuries occurring in day-to-day life. A skin injury usually manifests itself in the form of a wound or a cut. While a shallow wound may heal by itself within a short time, deep wounds require surgical interventions such as suturing for timely healing. Read More

    Hydroxyapatite cement cranioplasty following translabyrinthine approach: Long-term study of 369 cases.
    Laryngoscope 2017 Jan 6. Epub 2017 Jan 6.
    Department of Otolaryngology, Baton Rouge, Louisiana.
    Objective: To report the authors' experience with hydroxyapatite cement (HAC) cranioplasty and analyze the material's long-term safety and efficacy in repairing translabyrinthine skull-base defects by examining adverse events, specifically cerebrospinal fluid (CSF) leaks and surgical site infections.

    Study Design: Retrospective case-control study (primary study arm); prospective cross-sectional study of patients not examined within the last 5 years (secondary arm).

    Setting: tertiary-care neurotology private practice and academic practice (two centers). Read More

    Biocompatibility study of lithium disilicate and zirconium oxide ceramics for esthetic dental abutments.
    J Periodontal Implant Sci 2016 Dec 27;46(6):362-371. Epub 2016 Dec 27.
    Laboratory of Biomechanics and Bioengineering, Research Center of Royallieu, University of Technology of Compiègne, Sorbonne Universities, Compiègne, France.; Tufts University School of Dental Medicine, Boston, MA, USA.
    Purpose: The increasing demand for esthetically pleasing results has contributed to the use of ceramics for dental implant abutments. The aim of this study was to compare the biological response of epithelial tissue cultivated on lithium disilicate (LS2) and zirconium oxide (ZrO2) ceramics. Understanding the relevant physicochemical and mechanical properties of these ceramics will help identify the optimal material for facilitating gingival wound closure. Read More

    Exendin-4, a glucagon-like peptide-1 analogue, accelerates diabetic wound healing.
    J Surg Res 2017 Feb 17;208:93-103. Epub 2016 Sep 17.
    Department of Anesthesiology, Buddhist Tzu-Chi General Hospital and Tzu-Chi University School of Medicine, Hualien, Taiwan; Department of Anesthesiology, Taipei Medical University Hospital and School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:
    Background: Diabetes disregulates inflammatory responses and impairs vascular function in wounds. Glucagon-like peptide-1 receptor (Glp-1R) agonists are hypoglycemic agents with pleiotropic vascular protective and anti-inflammatory effects. The therapeutic potential of a Glp-1 analogue in a diabetic rat model of excisional wound injury was investigated. Read More

    Adhesion and metabolic activity of human corneal cells on PCL based nanofiber matrices.
    Mater Sci Eng C Mater Biol Appl 2017 Feb 26;71:764-770. Epub 2016 Oct 26.
    Department of Ophthalmology, Universität Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany. Electronic address:
    In this work, polycaprolactone (PCL) was used as a basic polymer for electrospinning of random and aligned nanofiber matrices. Our aim was to develop a biocompatible substrate for ophthalmological application to improve wound closure in defects of the cornea as replacement for human amniotic membrane. We investigated whether blending the hydrophobic PCL with poly (glycerol sebacate) (PGS) or chitosan (CHI) improves the biocompatibility of the matrices for cell expansion. Read More

    Silicon-dioxide-polyvinylpyrrolidone as a wound dressing for skin defects in a murine model.
    J Craniomaxillofac Surg 2017 Jan 15;45(1):99-107. Epub 2016 Oct 15.
    Department of Oral & Maxillofacial Plastic Surgery (Head: Frerich, Bernhard), University Medical Centre of Rostock, Schillingallee 35, 18057 Rostock, Germany. Electronic address:
    Objective: There is a high demand for temporary wound dressings that improve wound healing and regeneration. Silicon (as SiO2) has been shown to support the growth and collagen formation in biological systems.

    Methods: A nanocomposite was made from PVP (polyvinylpyrrolidon), nano-sized silica aggregates and water and served for fabrication of a wet dressing material (SiO2-PVP gel, by cross-linking the gel) and a freeze-dried dressing material (SiO2-PVP fleece). Read More

    Topical vanadate enhances the repair of median laparotomy incisions.
    J Surg Res 2017 Jan 31;207:102-107. Epub 2016 Aug 31.
    Department of Surgery, Penn State Hershey Medical Center, Hershey, Pennsylvania.
    Background: There are over two million laparotomies performed in the United States each year with an incisional hernia rate between 2% and 11%. A total of 100,000 ventral hernia repairs are undertaken each year with recurrences as high as 50%.

    Materials And Methods: Full thickness midline fascia incisions from the xiphoid to the pubic symphysis were made in rats. Read More

    Surgical site infection in tibial plateau fractures with ipsilateral compartment syndrome.
    Injury 2017 Feb 18;48(2):495-500. Epub 2016 Oct 18.
    R Adams Cowley Shock Trauma Center, Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:
    Aim: The aim of this study was to investigate the effects of compartment syndrome and timing of fasciotomy wound closure on surgical site infection (SSI) after surgical fixation of tibial plateau fractures. Our primary hypothesis was that SSI rate is increased for fractures with compartment syndrome versus those without, even accounting for confounders associated with infection. Our secondary hypothesis was that infection rates are unrelated to timing of fasciotomy closure or fixation. Read More

    The Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR) Procedure: An Early Feasibility Cohort Study.
    Orthop J Sports Med 2016 Nov 21;4(11):2325967116672176. Epub 2016 Nov 21.
    Division of Sports Medicine, Department of Orthopaedic Surgery, Boston Children's Hospital Boston, Massachusetts, USA.
    Background: This study assessed the safety of the newly developed bridge-enhanced anterior cruciate ligament (ACL) repair (BEAR), which involves suture repair of the ligament combined with a bioactive scaffold to bridge the gap between the torn ligament ends. As the intra-articular environment is complex in its response to implanted materials, this study was designed to determine whether there would be a significant rate of adverse reaction to the implanted scaffold.

    Hypothesis: The primary hypothesis was that the implanted scaffold would not result in a deep joint infection (arthrocentesis with positive culture) or significant inflammation (clinical symptoms justifying arthrocentesis but negative culture). Read More

    Flap Designs for Flap Advancement During Implant Therapy: A Systematic Review.
    Implant Dent 2017 Feb;26(1):145-152
    *Resident, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI. †Professor and Director of Graduate Periodontics, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI.
    Purpose: Guided bone regeneration (GBR) procedures allow ridge augmentation before or at time of implant placement. GBR outcomes rely on primary passive tension-free wound closure, which may be achieved by a variety of flap designs and surgical procedures. A comprehensive literature review of flap design and management is provided, including material types, incision design, reflection, releasing, and suturing techniques. Read More

    The effect of local hyperglycemia on skin cells in vitro and on wound healing in euglycemic rats.
    J Surg Res 2016 Dec 24;206(2):418-426. Epub 2016 Aug 24.
    Division of Plastic Surgery, Department of Surgery, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:
    Background: Multiple previous studies have established that high systemic blood glucose concentration impairs skin wound healing. However, the effects of local hyperglycemia on wound healing are not well defined. Comprehensive animal studies and in vitro studies using both fibroblasts and keratinocytes are lacking. Read More

    Osseous Repair in Minimally Invasive Reconstruction of Anterior Skull Base Defects.
    J Craniofac Surg 2017 Jan;28(1):36-39
    *Department of Otolaryngology †Department of Neurosurgery ‡University of Colorado School of Medicine, Aurora, CO §Department of Otolaryngology-Head and Neck Surgery, University of Kansas, Kansas City, KS ||Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA.
    Management of anterior skull base defects is an area of continued innovation for skull base surgeons. Various grafting materials have been advocated for the repair of skull base defects depending on needs, availability, harvest site morbidity, and surgeon preference. Spontaneous bony closure of small skull defects is known to occur in animal models without bone grafts, but this phenomenon has been unexplored in the human skull base. Read More

    Management of Open Lower Extremity Wounds With Concomitant Fracture Using a Porcine Urinary Bladder Matrix.
    Wounds 2016 Nov;28(11):387-394
    Background: Open wounds of the distal third of the leg and foot with exposed bone, fractures, and hardware are challenging wounds for which to achieve stable coverage. The orthopedic advances in lower extremity fracture management over the last 30 years have allowed a rethinking of the standard operative approach to close these complex wounds.

    Materials And Methods: The ability of extracellular matrix (ECM) products to facilitate constructive remodeling of a wound seemed a reasonable approach for treatment, especially in patients who are often poor surgical candidates for more advanced reconstructive procedures. Read More

    Influence of gold nanoparticles on wound healing treatment in rat model: Photobiomodulation therapy.
    Lasers Surg Med 2016 Nov 12. Epub 2016 Nov 12.
    Laser Center, Ibnu Sina Institute for Scientific and Industrial Research (ISI-SIR), Universiti Teknologi Malaysia, Johor Bahru, Johor 81310, Malaysia.
    Background And Objective: The aim of this study is to investigate the effect of gold nanoparticles (AuNPs) in photobiomodulation therapy (PBMT) on wound healing process.

    Materials And Methods: AuNPs are synthesized by Q-switched Nd:YAG laser ablation technique. Cutaneous wound are induced on 45 Sprague Dawley rats on its dorsal part and then randomly divided into three groups. Read More

    Impact of negative pressure wound therapy on open diaphyseal tibial fractures: A prospective randomized trial.
    J Clin Orthop Trauma 2016 Oct-Dec;7(4):256-259. Epub 2016 Jul 16.
    Department of Orthopaedics, Seth G.S. Medical College and K.E.M. Hospital, Mumbai, India.
    Introduction: Open tibial fractures are associated with a high incidence of mainly osteomyelitis. Negative pressure wound therapy (NPWT) is a novel form of treatment that uses subatmospheric pressure to effect early wound healing.

    Objectives And Study Design: To determine the effect of NPWT on incidence of deep infections/osteomyelitis after open tibial fractures using a prospective randomized study design. Read More

    Modulation of Cell Attachment, Proliferation, and Angiogenesis by Decellularized, Dehydrated Human Amniotic Membrane in In Vitro Models.
    Wounds 2017 Jan 24;29(1):28-38. Epub 2016 Oct 24.
    Celgene Cellular Therapeutics, Warren, NJ.
    Background: Decellularized, dehydrated human amniotic membrane (DDHAM) is an extracellular matrix devoid of cells, cell debris, and growth factors. This study examines the effect of cell attachment to the DDHAM and the induced cellular responses.

    Materials And Methods: The cell types employed in this study were human dermal fibroblasts (HDF), human epithelial keratinocytes (HEK), and human dermal microvascular endothelial cells (HDMEC), all of which play critical roles in the wound healing process. Read More

    Nuclear expression of IL-33 in epidermal keratinocytes promotes wound healing in mice.
    J Dermatol Sci 2017 Feb 17;85(2):106-114. Epub 2016 Oct 17.
    Departments of Dermatology at Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan. Electronic address:
    Background: Skin is the outermost tissue of the human body, and works as a mechanical, chemical, and biological barrier. The epidermis is the uppermost layer of the skin, and keratinocytes constitute the majority of epidermal cells. Wounds are disruptions of skin integrity, and cause tremendous disadvantages to humans; accordingly, rapid wound healing is very important. Read More

    Risk factors for reoperation after ileostomy reversal - Results from a prospective cohort study.
    Int J Surg 2016 Dec 1;36(Pt A):233-239. Epub 2016 Nov 1.
    Department of General, Visceral, and Vascular Surgery, Charité Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany. Electronic address:
    Background: Ileostomy reversal is frequently performed in abdominal surgery. Postoperative complications after ileostomy reversal are encountered in around 20% of patients. Data regarding risk factors for reoperation after ileostomy closure are scarce. Read More

    Root Canal Filling after Revascularization/Revitalization.
    J Clin Pediatr Dent 2016;40(6):445-449
    Introduction: Revascularization/revitalization therapy is considered an alternative procedure for management of teeth with an immature apex and necrotic pulp, mainly when root development is interrupted in the early phases of formation. However, this clinical treatment protocol should be considered a permanent procedure?

    Method: A maxillary central incisor with a previous and successful RR treatment was intentionally filled with a biocompatible material with the periapical tissues due to the patient's lack of adherence to the follow-up protocol.

    Results: The 20-month follow-up showed absence of clinical, radiological and tomographic signs and symptoms of an endodontic re-infection. Read More

    The wound healing trajectory and predictors with combined electric stimulation and conventional care: one outpatient wound care clinic's experience.
    Eur J Clin Invest 2016 Dec 2;46(12):1017-1023. Epub 2016 Nov 2.
    Department of Physical Therapy, Daemen College, Amherst, NY, USA.
    Background: Electric stimulation (E-stim) has been found to be an effective treatment in improving wound healing rates. However, the wound healing trajectory and its related predictors for complete wound closure (CWC) have not been reported with E-stim treatment.

    Materials And Methods: This was a retrospective study. Read More

    One - staged reconstruction of bladder exstrophy in male patients: long - term follow-up outcomes.
    Int Braz J Urol 2017 Jan-Feb;43(1):155-162
    Divisão de Urologia do Departamento de Cirurgia, Universidade de São Paulo, SP, Brasil.
    Introduction: The surgical correction of bladder exstrophy remains challenging. In our institution, the repair has evolved from a staged repair to one-stage reconstruction. The one-stage reconstruction includes; bladder closure, Cantwell-Ransley neourethroplasty and abdominoplasty using groin flaps, without the need of pelvic ostheotomies. Read More

    Treatment of digital pyogenic flexor tenosynovitis: single open debridement, irrigation, and primary wound closure followed by antibiotic therapy.
    Arch Orthop Trauma Surg 2017 Jan 27;137(1):141-145. Epub 2016 Oct 27.
    Unfall-, Hand- und Ellenbogenchirurgie, Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätsklinikum zu Köln, Cologne, Germany.
    Introduction: Digital pyogenic flexor tenosynovitis requires fast, aggressive treatment. Although this infection occurs frequently, treatment consensus is lacking.

    Materials And Methods: Between 2011 and 2015, 22 patients with acute pyogenic flexor tenosynovitis were treated with a single open debridement followed by irrigation; the incision was closed and a 10-day antibiotic course was administered. Read More

    0.1% Polyhexanide-Betaine Solution as an Adjuvant in a Case-Series of Chronic Wounds.
    Surg Technol Int 2016 Oct;XXIX:85-89
    B. Braun Medical Inc., Allentown, Pennsylvania.
    Introduction: The application of 0.1% polyhexanide-betaine gel and irrigating solution was used in place of saline during standard of care wound treatment for 70 chronic wounds of various etiologies. Our goal in this study sample was to investigate the number of days to wound closure, change in absolute wound size, and antimicrobial initiation from baseline visit, following application of polyhexanide-betaine in standard of care wound treatment. Read More

    On the biological performance of graphene oxide-modified chitosan/polyvinyl pyrrolidone nanocomposite membranes: In vitro and in vivo effects of graphene oxide.
    Mater Sci Eng C Mater Biol Appl 2017 Jan 28;70(Pt 1):121-131. Epub 2016 Aug 28.
    Department of Materials Science and Engineering, Sharif University of Technology, P.O. Box 11155-9161, Azadi Avenue, 14588 Tehran, Iran; Institute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box 11365-9466, Azadi Avenue, 14588 Tehran, Iran. Electronic address:
    Nanofibrous structures that mimic the native extracellular matrix and promote cell adhesion have attracted considerable interest for biomedical applications. In this study, GO-modified nanofibrous biopolymers (GO) were prepared by electrospinning blended solutions of chitosan (80vol%), polyvinyl pyrrolidone (15vol%), polyethylene oxide (5vol%) containing GO nanosheets (0-2wt%). It is shown that GO nanosheets significantly change the conductivity and viscosity of highly concentrated chitosan solutions, so that ultrafine and uniform fibers with an average diameter of 60nm are spinnable. Read More

    A randomized, controlled, multicentre clinical trial of post-extraction alveolar ridge preservation.
    J Clin Periodontol 2016 Dec 21;43(12):1188-1199. Epub 2016 Oct 21.
    Institute for Clinical Chemistry and Laboratory Medicine, Medical Center - University of Freiburg, Freiburg im Breisgau, Germany.
    Aim: To compare the effectiveness of two-ridge preservation treatments.

    Materials And Methods: Forty subjects with extraction sockets exhibiting substantial buccal dehiscences were enrolled and randomized across 10 standardized centres. Treatments were demineralized allograft plus reconstituted and cross-linked collagen membrane (DFDBA + RECXC) or deproteinized bovine bone mineral with collagen plus native, bilayer collagen membrane (DBBMC + NBCM). Read More

    Evaluation of wound healing activity of cow urine ark in diabetic Wistar albino rats.
    J Intercult Ethnopharmacol 2016 Sep-Dec;5(4):434-438. Epub 2016 Sep 25.
    Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India.
    Aim: To evaluate wound healing activity of cow urine ark in diabetic rats.

    Materials And Methods: Streptozotocin-induced diabetic Wistar albino rats were randomly divided into six groups (n = 6). Three groups - diabetic control, active control (glibenclamide), and treatment (cow urine ark) were operated for excision wounds (EWs). Read More

    Accelerated wound healing in a diabetic rat model using decellularized dermal matrix and human umbilical cord perivascular cells.
    Acta Biomater 2016 Nov 31;45:234-246. Epub 2016 Aug 31.
    Cellular and Molecular Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran; Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran; Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran. Electronic address:
    There is an unmet clinical need for novel wound healing strategies to treat full thickness skin defects, especially in diabetic patients. We hypothesized that a scaffold could perform dual roles of a biomechanical support and a favorable biochemical environment for stem cells. Human umbilical cord perivascular cells (HUCPVCs) have been recently reported as a type of mesenchymal stem cell that can accelerate early wound healing in skin defects. Read More

    Evaluation of dermal wound healing and in vitro antioxidant efficiency of Bacillus subtilis SPB1 biosurfactant.
    Biomed Pharmacother 2016 Dec 14;84:878-891. Epub 2016 Oct 14.
    Enzymes and Bioconversion Research Unit, Department of biological engineering, National School of Engineers of Sfax (ENIS), BP W, 3038 Sfax, Tunisia; Higher Institute of Biotechnology of Sfax (ISBS), BP 261, 3000 Sfax, Tunisia. Electronic address:
    Background: Lipopeptide microbial surfactants are endowed with unique surface properties as well as antimicrobial, anti-wrinkle, moisturizing and free radical scavenging activities. They were introduced safely in dermatological products, as long as they present low cytotoxicity against human cells. The present study was undertaken to evaluate the in vitro antioxidant activities and the wound healing potential of Bacillus subtilis SPB1 lipopeptide biosurfactant on excision wounds induced in experimental rats. Read More

    Negative pressure wound therapy for Gustilo Anderson grade IIIb open tibial fractures.
    Indian J Orthop 2016 Sep;50(5):536-542
    Department of Orthopedic Surgery, Yeungnam University Hospital, Daegu, Korea.
    Background: Traditionally, Gustilo Anderson grade IIIb open tibial fractures have been treated by initial wide wound debridement, stabilization of fracture with external fixation, and delayed wound closure. The purpose of this study is to evaluate the clinical and radiological results of staged treatment using negative pressure wound therapy (NPWT) for Gustilo Anderson grade IIIb open tibial fractures.

    Materials And Methods: 15 patients with Gustilo Anderson grade IIIb open tibial fractures, treated using staged protocol by a single surgeon between January 2007 and December 2011 were reviewed in this retrospective study. Read More

    Laparoscopic Stapled Sublay Repair With Self-Gripping Mesh: A Simplified Technique for Minimally Invasive Extraperitoneal Ventral Hernia Repair.
    Surg Technol Int 2016 Oct;XXIX:131-139
    Clinical Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California.
    Introduction: Minimally invasive laparoscopic and robotic techniques for ventral hernia repair have evolved to achieve the benefits and minimize the limitations of both the open Rives-Stoppa sublay mesh repair and laparoscopic intraperitoneal onlay mesh (IPOM) repair. By combining the principles of a retromuscular repair with the benefits of a minimally invasive approach, these techniques attempt to decrease recurrence, increase functionality, exclude mesh from the viscera, limit infection and wound complications, and minimize pain. The difficult ergonomics, challenging dissection, and extensive suturing make traditional laparoscopic sublay repair technically challenging and has led to increased robotic utilization to overcome these limitations. Read More

    Wound healing effects of deoxyshikonin isolated from Jawoongo: In vitro and in vivo studies.
    J Ethnopharmacol 2016 Oct 7. Epub 2016 Oct 7.
    Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 210-340, Korea. Electronic address:
    Ethnopharmacological Relevance: Jawoongo is a traditional drug ointment (with a traditional botanic formula) used for the treatment of burns and wounds in Korea. One of the components of Jawoongo is Lithospermi Radix (LR, the dried root of Lithospermum erythrorhizon Siebold & Zucc., also known as Zicao or Gromwell), which contains deoxyshikonin and its derivatives. Read More

    Efficacy and Safety of a Novel Autologous Wound Matrix in the Management of Complicated, Chronic Wounds: A Pilot Study.
    Wounds 2016 Sep;28(9):317-327
    Homecare Service, Israel Cancer Association and Geriatric-Palliative Service, Wolfson Medical Center, Holon, Israel.
    Introduction: The objective of this pilot study was to evaluate the efficacy and safety of a novel method using an autologous whole blood clot formed with the RedDress Wound Care System (RD1, RedDress Ltd, Israel), a provisional whole blood clot matrix used in the treatment of chronic wounds of various etiologies.

    Methods And Materials: Patients were treated at the bedside with the whole blood clot matrix. Blood was withdrawn from each patient using citrate, mixed with a calcium gluconate/kaolin suspension, and injected into an RD1 clotting tray. Read More

    Cold Plasma Welding System for Surgical Skin Closure: In Vivo Porcine Feasibility Assessment.
    Wounds 2016 Sep 29. Epub 2016 Sep 29.
    Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Tel Hashomer, Israel; and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, IonMed Ltd, Yokneam, Israel.
    Background: Cold plasma skin welding is a novel technology that bonds skin edges through soldering without the use of synthetic materials or conventional wound approximation methods such as sutures, staples, or skin adhesives. The cold plasma welding system uses a biological solder applied to the edges of a skin incision, followed by the application of cold plasma energy. The objectives of this study were to assess the feasibility of a cold plasma welding system in approximating and fixating skin incisions compared with conventional methods and to evaluate and define optimal plasma welding parameters and histopathological tissue response in a porcine model. Read More

    Contemporary Trends in the Inpatient Management of Fournier's Gangrene: Predictors of Length of Stay and Mortality Based on Population-Based Sample.
    Urology 2016 Sep 27. Epub 2016 Sep 27.
    Department of Urology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma.
    Objective: To describe clinical management of Fournier's gangrene, and to characterize predictive factors associated with inpatient mortality and extended hospital stay.

    Materials And Methods: The National Inpatient Sample was queried from 2004 to 2012 based on ICD-9-CM procedural and diagnosis codes. Patients admitted for Fournier's gangrene who underwent debridement were selected. Read More

    Refinement of Tissue-Engineering Chamber Implantation in the Rat.
    J Invest Surg 2016 Oct 3:1-6. Epub 2016 Oct 3.
    a Department of Plastic, Reconstructive, Hand and Burn Surgery , BG Trauma Center, Eberhard Karls University Tübingen , Tübingen , Germany.
    Purpose: Rodent in vivo models that successfully generate new adipose, muscle, or vascular tissue in a tissue-engineering chamber (TEC) has advanced in the last decade. In this article, technical refinements in these operative foreign body implantations have been described to improve the execution of animal models in a way so that they can reduce wastage of time and resources.

    Materials & Methods: Male Sprague-Dawley rats were studied and randomly divided into two equal sized groups. Read More

    Thoracoabdominal necrotising soft tissue infection secondary to enterocutaneous fistulae: a case report.
    J Wound Care 2016 Oct;25(Sup10):S4-S7
    Department of Surgery, Augusta University, Augusta, GA.
    Objective: Necrotising soft tissue infection is a rare surgical emergency, which requires immediate and aggressive surgical debridement. Following control of the infection, patients are often left with large defects, with wound reconstruction and closure creating significant challenges. Here we describe a case of extensive thoracoabdominal necrotising soft tissue infection and provide a discussion on the standard of care and treatment based on a current literature review. Read More

    Results of a statewide survey of surgeons' care practices for emergency Hartmann's procedure.
    J Surg Res 2016 Sep 9;205(1):108-14. Epub 2016 Jun 9.
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan; Michigan Surgical Quality Collaborative, Ann Arbor, Michigan.
    Background: Emergency general surgery is associated with high morbidity and mortality but has seldom been targeted for practice improvement. The goal of this study was to determine whether perioperative practices vary among surgeons for emergency Hartmann's procedures and whether perioperative care practices are associated with hospitals' complication rates.

    Materials And Methods: We conducted a survey of surgeons at 27 Michigan hospitals. Read More

    Unused sterile instruments for closure prevent wound surgical site infection after pancreatic surgery.
    J Surg Res 2016 Sep 4;205(1):38-42. Epub 2016 Mar 4.
    Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan. Electronic address:
    Background: The incidence of incisional surgical site infection (SSI) after pancreatic surgery remains high. The aim of this study was to assess the effectiveness of the unused sterile instruments that were not used throughout the course of surgery and were opened exactly at the moment of wound closure to prevent incisional SSI after open pancreatic surgery.

    Materials And Methods: We retrospectively evaluated the incidence of incisional SSI and the clinical course in 203 patients who underwent pancreatic resection in our institution between April 2012 and October 2015. Read More

    Single-stage treatment of chronic osteomyelitis with a new absorbable, gentamicin-loaded, calcium sulphate/hydroxyapatite biocomposite: a prospective series of 100 cases.
    Bone Joint J 2016 Sep;98-B(9):1289-96
    Nuffield Orthopaedic Centre, The Bone Infection Unit, Oxford University Hospitals Foundation NHS Trust, Oxford OX3 7HE, UK.
    Aims: Chronic osteomyelitis may recur if dead space management, after excision of infected bone, is inadequate. This study describes the results of a strategy for the management of deep bone infection and evaluates a new antibiotic-loaded biocomposite in the eradication of infection from bone defects.

    Patients And Methods: We report a prospective study of 100 patients with chronic osteomyelitis, in 105 bones. Read More

    Systematic review and meta-analysis of sutures coated with triclosan for the prevention of surgical site infection after elective colorectal surgery according to the PRISMA statement.
    Medicine (Baltimore) 2016 Aug;95(35):e4057
    School of Medicine and Surgery, Milano-Bicocca University, San Gerardo Hospital, Monza, Italy.
    Background: Several randomized clinical trials (RCTs) conducted to evaluate the effect of triclosan-coated suture on surgical site infection (SSI) yield to controversial results. The primary purpose of this systematic review and meta-analysis was to analyze the available RCTs, comparing the effect of triclosan-coated suture with uncoated suture on the incidence of SSI after elective colorectal operations. As secondary endpoint of the analysis, we considered length of hospital stay after surgery. Read More

    Biomechanical comparison of straight and helical compression plates for fixation of transverse and oblique bone fractures: Modeling and experiments.
    Biomed Mater Eng 2016 Aug;27(2-3):197-209
    Department of Metallurgy and Materials Engineering, Faculty of Engineering, Tunceli University, Tunceli, Turkey.
    Total deformation and stability of straight and helical compression plates were studied by means of the finite element method (FEM) and in vitro biomechanical experiments. Fixations of transverse (TF) and oblique (45°) bone (OF) fractures have been analyzed on sheep tibias by designing the straight compression (SP) and Helical Compression Plate (HP) models. The effects of axial compression, bending and torsion loads on both plating systems were analyzed in terms of total displacements. Read More

    Wound healing applications of sericin/chitosan-capped silver nanoparticles incorporated hydrogel.
    Drug Deliv Transl Res 2017 Feb;7(1):77-88
    Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Vidya Vihar, Raebareli Road, Lucknow, UP, 226025, India.
    Microbial contamination in wounds leading to severe sepsis can be treated by silver-based antiseptics. However, frequent application of silver-based antiseptics, staining of skin, burning, and irritation at application site resulted to poor patient compliances. Thus, we formulated sericin- and chitosan-capped silver nanoparticle (S/C-SNP)-loaded hydrogel for accelerated wound healing and antimicrobial properties. Read More

    Photobiomodulation (Laser and LED) on Sternotomy Healing in Hyperglycemic and Normoglycemic Patients Who Underwent Coronary Bypass Surgery with Internal Mammary Artery Grafts: A Randomized, Double-Blind Study with Follow-Up.
    Photomed Laser Surg 2017 Jan 25;35(1):24-31. Epub 2016 Aug 25.
    1 Lasertherapy and Photobiology Center, Research and Development Institute, IP&D, Universidade do Vale do Paraíba , UNIVAP, São Paulo, Brazil .
    Background And Objective: This study aimed at analyzing the healing effects of low-level laser therapy (LLLT) (λ620 nm, 6 J/cm(2)) and light-emitting diode (LED) therapy (λ640 nm, 6 J/cm(2)) on the longitudinal sternotomy incisions of hyperglycemic and normoglycemic patients who underwent coronary artery bypass grafting (CABG).

    Materials And Methods: 120 volunteers were electively submitted to CABG and were randomly allocated into four different groups of equal size (n = 30): control, placebo, laser (λ of 640 nm and spatial average energy fluency [SAEF] of 1.06 J/cm(2)), and LED (λ of 660 ± 20 nm and SAEF of 0. Read More

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