2,086 results match your criteria Materials for Wound Closure


Developing A Synthetic Composite Membrane For Cleft Palate Repair.

J Tissue Eng Regen Med 2019 Apr 11. Epub 2019 Apr 11.

Department of Materials Science &Engineering, Kroto Research Institute, University of Sheffield, Sheffield, UK.

An oronasal fistula is a passage between the oral and nasal cavity. Currently, surgical procedures use mucosal flaps or collagen grafts to make a barrier between oral and nasal cavities. Our aim was to develop a cell-free synthetic repair material for closure of nasal fistulas. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/term.2867
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http://dx.doi.org/10.1002/term.2867DOI Listing
April 2019
4 Reads
5.199 Impact Factor

Fibrin Sealant Derived from Human Plasma as a Scaffold for Bone Grafts Associated with Photobiomodulation Therapy.

Int J Mol Sci 2019 Apr 10;20(7). Epub 2019 Apr 10.

Department of Biological Sciences (Anatomy), Bauru School of Dentistry, University of São Paulo (USP), Bauru 17012-901, Brazil.

Fibrin sealants derived from human blood can be used in tissue engineering to assist in the repair of bone defects. The objective of this study was to evaluate the support system formed by a xenograft fibrin sealant associated with photobiomodulation therapy of critical defects in rat calvaria. Thirty-six rats were divided into four groups: BC ( = 8), defect filled with blood clot; FSB ( = 10), filled with fibrin sealant and xenograft; BC ( = 8), blood clot and photobiomodulation; FSB ( = 10), fibrin sealant, xenograft, and photobiomodulation. Read More

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https://www.mdpi.com/1422-0067/20/7/1761
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http://dx.doi.org/10.3390/ijms20071761DOI Listing
April 2019
7 Reads

Postoperative Complications of Plastic and Reconstructive Surgery in Solid Organ Transplant Recipients.

J Craniofac Surg 2019 Mar 28. Epub 2019 Mar 28.

Department of Plastic and Reconstructive Surgery, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.

Introduction: As the number of organ transplants and the survival rate increase, solid organ transplant patients will need more plastic and reconstructive surgery. However, such patients take immunosuppressants, including prednisone, which makes wound healing slower and plastic surgeons more hesitate to operate. In this study, we examined postoperative complications of organ transplant patients who have undergone plastic and reconstructive surgery. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005511DOI Listing
March 2019
3 Reads

Clinical experience using a dehydrated amnion/chorion membrane construct for the management of wounds.

Wounds 2019 Apr;31(4 Suppl):S19-S27

Ali Anaim, DPM PC, Philadelphia, PA; Temple University Hospital, Philadelphia, PA; Episcopal Hospital, Philadelphia, PA; Nazareth Hospital, Philadelphia, PA; Phoenixville Hospital, Phoenixville, PA; Pennsylvania Surgery and Laser Center, Philadelphia, PA.

Introduction: Over time, acute and chronic, nonhealing wounds impose heavy financial and quality-of-life burdens on patients. The introduction of new therapies for wounds is essential in benefiting the patient, and in this report, the clinical experience of various wound care providers treating wounds with dehydrated amnion/chorion membrane (dACM) is presented.

Objective: This retrospective clinical experience evaluated the effects of dACM in the treatment of 50 acute and chronic wounds of various etiologies. Read More

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April 2019
1 Read

Surgical treatment of hydatidothorax in children: A retrospective study of 19 patients.

J Pediatr Surg 2019 Mar 19. Epub 2019 Mar 19.

Department of Pediatric, Children Hospital, Rabat, Morocco; Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.

Objective: The objective of this study was to describe the role of surgical management of ruptured hydatid cysts into the pleural cavity in children. A review of the management of patients with intrapleural rupture of pulmonary hydatid cysts in children at our center was performed.

Materials And Methods: A retrospective chart review was performed on all children who developed intrapleural rupture of a hydatid cyst in the lung. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.03.003DOI Listing
March 2019
2 Reads

A Prospective, Single-center, Open-label Case Series Evaluating the Clinical Outcomes of Lyopreserved Placental Membrane Containing Viable Cells in the Treatment of Chronic Wounds.

Wounds 2019 Apr;31(4):97-102

Osiris Therapeutics, Inc, Columbia, MD.

Introduction: Cryopreserved placental membrane containing viable cells (vCPM) in conjunction with standard of care (SOC) has shown clinical effectiveness in several studies for the management of acute and chronic wounds. Recently, a new lyophilization technique has been developed that allows viable tissues to be stored at room temperature as a structural and functional equivalent to vCPM.

Objective: This case series evaluates the clinical outcomes of a lyopreserved placental membrane containing viable cells (vLPM) for the management of chronic wounds of various etiologies. Read More

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April 2019
3 Reads

Risk factors for incisional surgical site infection after elective laparoscopic colorectal surgery.

Ann Gastroenterol Surg 2019 Mar 11;3(2):202-208. Epub 2019 Jan 11.

Department of Gastroenterological Surgery Graduate School of Medicine Yokohama City University Yokohama Japan.

Background: Surgical site infection (SSI) is a common morbidity in patients undergoing colorectal surgery, and the focus of previous studies has primarily been on incisional SSI. Most reports thus far have focused on open surgery rather than on laparoscopic colorectal surgery (Lap CR). Therefore, the aim of the present study was to identify the risk factors for incisional SSI in patients undergoing elective Lap CR. Read More

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http://dx.doi.org/10.1002/ags3.12229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422835PMC
March 2019
1 Read

Reduced wound leakage in arthroplasty with modified wound closure: a retrospective cohort study.

Arch Orthop Trauma Surg 2019 Mar 25. Epub 2019 Mar 25.

Department of Orthopaedics, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, Hertogenbosch, The Netherlands.

Introduction: Wound leakage has been shown to increase the risk of prosthetic joint infections (PJIs) in primary total hip (THA) and knee arthroplasty (unicondylar and total knee arthroplasty; KA). The aim of this study is to determine whether the addition of a continuous subcuticular bonding stitch to a conventional three-layer closure method reduces the incidence of prolonged wound leakage and PJIs after THA and KA.

Materials And Methods: This retrospective cohort study included all patients receiving a THA or KA. Read More

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http://dx.doi.org/10.1007/s00402-019-03178-8DOI Listing
March 2019
1 Read

Effects of Periploca forrestii Schltr on wound healing by Src meditated Mek/Erk and PI3K/Akt signals.

J Ethnopharmacol 2019 Mar 21;237:116-127. Epub 2019 Mar 21.

Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:

Ethnopharmacological Relevance: Periploca forrestii Schltr. (PF) is a traditional folk medicine in China that has been used widely for treating rheumatoid arthritis and traumatic injuries for a long history. Previously, we have roughly demonstrated that the ethanol extract of PF possessed in vitro wound healing potential, and more in depth research deserves to be conducted. Read More

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http://dx.doi.org/10.1016/j.jep.2019.03.046DOI Listing
March 2019
2 Reads

Towards a modern approach to traditional use: In vitro and in vivo evaluation of Alchemilla vulgaris L. gel wound healing potential.

J Ethnopharmacol 2019 Mar 20. Epub 2019 Mar 20.

Institute for Medicinal Plant Research "Dr Josif Pančić", Department of Pharmaceutical Research and Development, Tadeuša Košćuška 1, 11 000, Belgrade, Serbia.

Ethnopharmacological Relevance: Alchemilla vulgaris is an important remedy in European folk medicine, known for its adstringent and anti-inflammatory properties; it is traditionally used to heal gynecological and gastrointestinal diseases. Despite its folkloric use in wound healing, there is a lack of scientific data to support this therapeutic application.

Aim Of The Study: To analyze the wound healing potential of different solvent A. Read More

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http://dx.doi.org/10.1016/j.jep.2019.03.016DOI Listing
March 2019
1 Read
2.998 Impact Factor

Continuous Versus Interrupted Sutures for Primary Cleft Palate Repair.

Plast Reconstr Surg Glob Open 2018 Nov 13;6(11):e2001. Epub 2018 Nov 13.

University of Veterinary and Animal Sciences, Lahore.

Background: Cleft palate is a common congenital problem. It is traditionally surgically repaired with interrupted sutures between the ages of 6 and 18 months, with the aim of achieving closure of both nasal and oral layers. In various fields of surgery, continuous, rather than interrupted, sutures are the norm. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414111PMC
November 2018
1 Read

The Surgical Suture.

Authors:
Miriam Byrne Al Aly

Aesthet Surg J 2019 Mar;39(Supplement_2):S67-S72

Department of Plastic, Reconstructive, and Aesthetic Surgery, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.

Surgeons must select the optimal suture materials for tissue approximation to maximize wound healing and scar aesthetics. Thus, knowledge regarding their characteristics is crucial to minimize ischaemia, excess wound tension, and tissue injury. This article describes the selection of various suture materials available today and their intended design. Read More

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https://academic.oup.com/asj/article/39/Supplement_2/S67/537
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http://dx.doi.org/10.1093/asj/sjz036DOI Listing
March 2019
9 Reads

Sea bass (Lateolabrax maculatus) accelerates wound healing: A transition from inflammation to proliferation.

J Ethnopharmacol 2019 May 9;236:263-276. Epub 2019 Mar 9.

Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. Electronic address:

Ethnopharmacological Relevance: Sea bass (Lateolabrax maculatus) has been used for dietary therapy practice for wound healing of puerperal or surgery patients in China. Traditional Chinese medicinal books also documented that sea bass can be used to manage inflammation-associated conditions such as wound, miscarriage and cough. Some studies also proved that dietary supplement with fish benefited for treating many inflammatory - associated conditions, such as cardiovascular disease, ulcerative colitis and hyperlipidemia. Read More

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http://dx.doi.org/10.1016/j.jep.2019.03.012DOI Listing
May 2019
2 Reads

Chinese Trauma Surgeon Association for management guidelines of vacuum sealing drainage application in abdominal surgeries-Update and systematic review.

Chin J Traumatol 2019 Feb 14;22(1):1-11. Epub 2019 Feb 14.

The First Affiliated Hospital of Third Military Medical University, Chongqing, China.

Vacuum sealing drainage (VSD) is frequently used in abdominal surgeries. However, relevant guidelines are rare. Chinese Trauma Surgeon Association organized a committee composed of 28 experts across China in July 2017, aiming to provide an evidence-based recommendation for the application of VSD in abdominal surgeries. Read More

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http://dx.doi.org/10.1016/j.cjtee.2018.10.005DOI Listing
February 2019
1 Read

Influence of wound closure on volume stability with the application of different GBR materials: an cone-beam computed tomographic study.

J Periodontal Implant Sci 2019 Feb 22;49(1):14-24. Epub 2019 Feb 22.

Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.

Purpose: To assess the influence of using different combinations of guided bone regeneration (GBR) materials on volume changes after wound closure at peri-implant dehiscence defects.

Methods: In 5 pig mandibles, standardized bone defects were created and implants were centrally placed. The defects were augmented using different combinations of GBR materials: xenogeneic granulate and collagen membrane (group 1, n=10), xenogeneic granulate and alloplastic membrane (group 2, n=10), alloplastic granulates and alloplastic membrane (group 3, n=10). Read More

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http://dx.doi.org/10.5051/jpis.2019.49.1.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399090PMC
February 2019

A Bi-Layer PVA/CMC/PEG Hydrogel with Gradually Changing Pore Sizes for Wound Dressing.

Macromol Biosci 2019 Mar 6:e1800424. Epub 2019 Mar 6.

Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, 229 North Taibai Road, Xi'an, 710069, China.

Wound dressings are vital for cutaneous wound healing. In this study, a bi-layer dressing composed of polyvinyl alcohol/carboxymethyl cellulose/polyethylene glycol (PVA/CMC/PEG) hydrogels is produced through a thawing-freezing method based on the study of the pore size of single-layer hydrogels. Then the physical properties and healing of full-thickness skin defects treated with hydrogels are inspected. Read More

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http://dx.doi.org/10.1002/mabi.201800424DOI Listing
March 2019
3.851 Impact Factor

Effect of Incise Drape on Contamination Rate of Surgical Wound during Surgical Procedures of Lumbar Spine.

Adv Biomed Res 2019 31;8. Epub 2019 Jan 31.

Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The aim of this study was to investigate the effect of the incise drape (ID) on surgical wound bacterial contamination during lumbar spine surgical procedures in treatment group (with ID) and control group (without ID).

Materials And Methods: The present study was conducted on 88 patients who were a candidate for lumbar spine surgery. The patients were randomly assigned to one of the two groups, treatment and control. Read More

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http://dx.doi.org/10.4103/abr.abr_226_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385563PMC
January 2019
1 Read

Mid- to Long-term Outcomes After Split-thickness Skin Graft Skin Extension by Multiple Incisions.

In Vivo 2019 Mar-Apr;33(2):453-464

Section Upper Extremity, Foot- and Rheuma Surgery, Trauma Department, Medical School Hanover (MHH), Hanover, Germany

Background/aim: Skin extension by multiple incisions (SEMI) may be superior to split-thickness skin graft (STSG) for closure of large soft tissue defects.

Materials And Methods: Twenty-six patients who had undergone STSG were compared to 29 patients who had undergone SEMI on the extremities. Patient and Observer Scar Assessment Scale (POSAS), Dermatology Life Quality Index, Wound QoL (Quality of Life) and Short Form Health Survey 36 were used. Read More

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http://dx.doi.org/10.21873/invivo.11494DOI Listing
December 2018

A Novel Recombinant Human Collagen-based Flowable Matrix for Chronic Lower Limb Wound Management: First Results of a Clinical Trial.

Wounds 2019 Apr 14;31(4):103-107. Epub 2019 Feb 14.

Department of Plastic Surgery, Assaf Harofeh Medical Center, Zerifin, Israel.

Background: Chronic ulcers pose a significant health concern and economic burden. Numerous products, including animal-derived collagen products, have been designed to provide the injured site with a biocompatible structural matrix that promotes tissue regeneration. Yet, animal-derived collagens can evoke immune responses, bear risk of disease transmission, and fail to closely mimic the function of native collagen. Read More

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April 2019
2 Reads

Wound healing activity and mechanism of action of antimicrobial and lipopolysaccharide-neutralizing peptides from enzymatic hydrolysates of rice bran proteins.

J Biosci Bioeng 2019 Feb 21. Epub 2019 Feb 21.

Department of Materials Science and Technology, Graduate School of Science and Technology, Niigata University, Niigata 950-2181, Japan.

In our previous study, we identified multifunctional cationic peptides from enzymatic hydrolysates of rice bran proteins (RBPs) that have antimicrobial and lipopolysaccharide-neutralizing activities. In this study, we investigated the potential of the peptides RBP-LRR, RBP-EKL, and RBP-SSF to promote proliferation, angiogenesis (tube formation), and migration in human umbilical vein endothelial cells (HUVECs). To determine mechanisms of wound healing actions, angiogenic and migration-promoting activities of these peptides were evaluated following pretreatments of HUVECs with specific inhibitors. Read More

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http://dx.doi.org/10.1016/j.jbiosc.2019.02.002DOI Listing
February 2019
1 Read

A fibrinous and allogeneic fibroblast-enriched membrane as a biocompatible material can improve diabetic wound healing.

Biomater Sci 2019 Feb 22. Epub 2019 Feb 22.

Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran. and Department of Hematology and Laboratory Sciences, Faculty of Allied Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran.

The application of conventional approaches to diabetic wound regeneration has some limitations. Thus, skin substitutes could be a new therapeutic possibility. In this regard, fibrin scaffolds are promising materials due to their desirable characteristics. Read More

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http://xlink.rsc.org/?DOI=C8BM01377B
Publisher Site
http://dx.doi.org/10.1039/c8bm01377bDOI Listing
February 2019
2 Reads

Adipose tissue -derived mesenchymal stem cells and keratinocytes co-culture on Gelatin/Chitosan/β- Glycerol Phosphate Nanoscaffold in skin regeneration.

Cell Biol Int 2019 Feb 21. Epub 2019 Feb 21.

Stem Cell and Regenerative Medicine Research Group, Academic Center for Education, Culture and Research(ACECR), Razavi Khorasan Branch, Mashhad, Iran.

Using cell-based engineered skin is an emerging strategy for treating difficult-to-heal wounds To date, much endeavor has been devoted to the -fabrication of appropriate scaffolds with suitable biomechanical properties to support cell viability and growth in the microenvironment of a wound. The aim of this research was to assess the impact of adipose tissue-derived mesenchymal stem cells (AD-MSCs) and keratinocytes on Gelatin/Chitosan/β-Glycerol Phosphate (GCGP) nanoscaffold in full-thickness excisional skin wound healing of rats. . Read More

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http://dx.doi.org/10.1002/cbin.11119DOI Listing
February 2019
1 Read
1.933 Impact Factor

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing.

Small 2019 Mar 20;15(12):e1900046. Epub 2019 Feb 20.

Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.

Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full-thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide (rGO) using a H O /HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. Read More

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http://dx.doi.org/10.1002/smll.201900046DOI Listing
March 2019
1 Read

Dynamic Histological Events and Molecular Changes in Excisional Wound Healing of Diabetic DB/DB Mice.

J Surg Res 2019 Jun 13;238:186-197. Epub 2019 Feb 13.

Department of Plastic Surgery, Rhode Island Hospital, Warren Alpert School of Medicine, Brown University, Providence, Rhode Island.

Background: Wound contraction and re-epithelialization over the entire healing process had never been histologically examined daily in diabetic mouse wounds. Correlating morphological characters with molecular changes may be essential to understand the potential mechanism of impeded diabetic wound healing.

Materials And Methods: In 99 db/db and 63 db/m mice, dorsal-paired 8 mm-diameter wounds were created. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.048DOI Listing
June 2019
1 Read

The influence of wound closure on graft stability: An in vitro comparison of different bone grafting techniques for the treatment of one-wall horizontal bone defects.

Clin Implant Dent Relat Res 2019 Apr 11;21(2):284-291. Epub 2019 Feb 11.

Department of Oral- and Cranio-Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.

Objectives: The aim of this preclinical study was to analyze and compare different grafting techniques with respect to volume stability after wound closure.

Materials And Methods: Four different grafting techniques were evaluated in vitro for volume stability in a one-wall horizontal defect configuration. Group 1: guided bone regeneration (GBR) with collagen membrane, particulated xenograft; group 2: GBR with collagen membrane, particulated xenograft, pins; group 3: GBR with titanium-reinforced membrane, particulated xenograft, pins; group 4: autogenous block graft, particulated xenograft, collagen membrane. Read More

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http://dx.doi.org/10.1111/cid.12728DOI Listing

Novel synthesized zinc oxide nanoparticles loaded alginate-chitosan biofilm to enhanced wound site activity and anti-septic abilities for the management of complicated abdominal wound dehiscence.

J Photochem Photobiol B 2019 Mar 30;192:124-130. Epub 2019 Jan 30.

Department of Emergency, Linyi Central Hospital, Linyi 276400, Shandong, China. Electronic address:

Wound dehiscence is a surgical complication and its management is inevitable because 25% to 35% of patients suffered from post laparotomy wound dehiscence. The excellent biodegradability and biocompatibility of chitosan and alginate have provided ample space for future developments in biomedical applications. Hence, the present work is directed towards the synthesis of robust biofilm made up of chitosan (CS), zinc oxide (ZnO) nanoparticles and Alginate (Alg). Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.01.019DOI Listing
March 2019
2 Reads

To Evaluate the Efficacy and Effectiveness of N-butyl-2-cyanoacrylate glue (TRU SEAL) in Closure of Oral and Maxillofacial Laceration and Surgical Incisions.

J Maxillofac Oral Surg 2019 Mar 21;18(1):131-138. Epub 2018 Apr 21.

Mysuru, India.

Introduction: Effective wound closure is critical for minimizing wound complications and preventing wound dehiscence. The various wound closure techniques include staples, traditional nylon and skin sutures, subcuticular sutures, and skin adhesives. Currently topical skin adhesives are frequently being used. Read More

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http://dx.doi.org/10.1007/s12663-018-1111-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328818PMC

Buccal Fat Pad: A Useful Adjunct Flap in Cleft Palate Repair.

J Maxillofac Oral Surg 2019 Mar 5;18(1):40-45. Epub 2018 Mar 5.

2Department of Surgery, University of Sokoto, Sokoto, Nigeria.

Aim: The aim of the study is to describe the technique and also the outcome of using buccal fat pad (BFP) as an adjunct flap in cleft palate repair and to report the surgical outcome.

Materials And Methods: All the surgical repairs with BFP were done under general anaesthesia. The use of BFP was indicated in patients who needed a secondary palatal cleft repair, those with wide palatal clefts or patients whose primary palatal cleft repair was complicated intraoperatively by inadvertent tearing of the nasal mucosa. Read More

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http://dx.doi.org/10.1007/s12663-018-1100-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328837PMC
March 2019
1 Read

A Randomized Controlled Trial Comparing a Human Acellular Dermal Matrix Versus Conventional Care for the Treatment of Venous Leg Ulcers.

Authors:
Shawn Cazzell

Wounds 2019 Mar 31;31(3):68-74. Epub 2019 Jan 31.

Limb Preservation Platform, Valley Vascular Surgical Associates, Fresno, CA.

Introduction: Venous leg ulcers (VLUs) are often chronic and difficult to treat, which makes alternative options to conventional care necessary to improve ulcer healing rates. While human acellular dermal matrices (ADMs) have shown promise in treating diabetic foot ulcers, no comparative studies have been published regarding VLU treatment. Decellularized ADMs (D-ADMs) have been used successfully in the treatment of a wide variety of wound repairs and may be effective in treating VLUs. Read More

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March 2019
4 Reads

Defective Black Nano-Titania Thermogels for Cutaneous Tumor-Induced Therapy and Healing.

Nano Lett 2019 03 7;19(3):2138-2147. Epub 2019 Feb 7.

State Key Laboratory of High-Performance Ceramics and Superfine Microstructure , Shanghai Institute of Ceramics, Chinese Academy of Sciences , 1295 Dingxi Road , Shanghai 200050 , People's Republic of China.

Current challenges in cutaneous tumor therapy are healing the skin wounds resulting from surgical resection and eliminating possible residual tumor cells to prevent recurrence. To address this issue, bifunctional biomaterials equipped with effective tumor therapeutic capacity for skin cancers and simultaneous tissue regenerative ability for wound closure are highly recommended. Herein, we report an injectable thermosensitive hydrogel (named BT-CTS thermogel) with the integration of nanosized black titania (B-TiO, ∼50 nm) nanoparticles into a chitosan (CTS) matrix. Read More

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http://dx.doi.org/10.1021/acs.nanolett.9b00367DOI Listing
March 2019
1 Read

Effect of dual-drug-releasing micelle-hydrogel composite on wound healing in vivo in full-thickness excision wound rat model.

J Biomed Mater Res A 2019 May 18;107(5):1094-1106. Epub 2019 Feb 18.

School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, 923-1292, Japan.

Wound healing is a complex process involving an intricate cascade of body responses. A composite dressing that would effectively target different stages of wound healing and regeneration is urgently needed. In the current study, we tested the efficacy of a previously prepared micelle-hydrogel composite loaded with two drugs, in full-thickness excision wound model in rat. Read More

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http://doi.wiley.com/10.1002/jbm.a.36639
Publisher Site
http://dx.doi.org/10.1002/jbm.a.36639DOI Listing
May 2019
8 Reads

Effects of low-dose ketamine infusion on remifentanil-induced acute opioid tolerance and the inflammatory response in patients undergoing orthognathic surgery.

J Pain Res 2019 17;12:377-385. Epub 2019 Jan 17.

Department of Dental Anesthesiology and Pain Management, Tohoku University Hospital, Sendai, Miyagi, Japan,

Purpose: Remifentanil is associated with acute opioid tolerance that can lead to increased postoperative consumption of opioid analgesics. The purpose of this study was to determine whether a low dose of ketamine prevents remifentanil-induced acute opioid tolerance and affects the neutrophil-lymphocyte ratio (NLR), a newly recognized biomarker of inflammation.

Materials And Methods: Forty patients undergoing orthognathic surgery were enrolled in this prospective, randomized, double-blind study and randomly assigned to intraoperative administration of one of the following anesthetic regimens: high-dose remifentanil (0. Read More

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http://dx.doi.org/10.2147/JPR.S177098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342226PMC
January 2019

Negative-Pressure Wound Therapy in Infants and Children: A Population-Based Study.

J Surg Res 2019 Mar 30;235:560-568. Epub 2018 Nov 30.

Division of Plastic Surgery, Department of Surgery, Washington University, St. Louis, Missouri. Electronic address:

Background: Although the safety and benefits of negative-pressure wound therapy (NPWT) have been clearly demonstrated in the adult population, studies evaluating the safety and describing the use of NPWT in the pediatric population have been limited. Given this paucity, the goals of this study were to (1) evaluate the literature dedicated to NPWT use in infants and children and (2) leverage a population-level analysis to describe the experience of NPWT use in the pediatric population.

Materials And Methods: We performed a literature review and analyzed the Truven Health Analytics MarketScan Commercial Claims Databases from 2006 to 2014 to identify infants and children treated with NPWT. Read More

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http://dx.doi.org/10.1016/j.jss.2018.10.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364568PMC
March 2019
1 Read

Multifunctional Silicon-Carbon Nanohybrids Simultaneously Featuring Bright Fluorescence, High Antibacterial and Wound Healing Activity.

Small 2019 Mar 25;15(9):e1803200. Epub 2019 Jan 25.

Laboratory of Nanoscale Biochemical Analysis, Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, China.

In this work, a class of multifunctional silicon-carbon nanohybrids (designated as SiCNs), which simultaneously possess aqueous dispersibility, bright fluorescence (photoluminescence quantum yield [PLQY]: ≈28%), as well as high antibacterial and wound healing activity, is presented. Taking advantage of these unique merits, cell distribution and pharmacological behavior of the SiCNs is first investigated through tracking their strong and stable fluorescence. The high bacteria inhibition ability (≈82. Read More

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http://dx.doi.org/10.1002/smll.201803200DOI Listing
March 2019
7 Reads

Periplocin promotes wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase.

Phytomedicine 2019 Apr 11;57:72-83. Epub 2018 Dec 11.

Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Background: Periploca forrestii(PF) is mainly utilized for treatment of arthritis and traumatic injury historically. We had previously demonstrated that a fraction rich in cardiotonic steroids isolated from PF had the potential to facilitate wound healing. However, the exact material basis and mechanism of action responsible for wound healing is still unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183060
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http://dx.doi.org/10.1016/j.phymed.2018.12.015DOI Listing
April 2019
11 Reads

A Systematic Review of Suture Technologies in Total Knee Arthroplasty.

Surg Technol Int 2019 Jan 18;34. Epub 2019 Jan 18.

Department of Orthopaedic Surgery, Lenox Hill Hospital, Northwell Health, New York, New York.

Over time, various materials and techniques have been developed for superficial and deep wound closure. However, potential complications, such as infections and dehiscences, can still occur, driving the development of new closure modalities. As wound closure technology continues to advance and change, the need to continuously evaluate the current techniques and materials persists. Read More

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January 2019
15 Reads

Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration.

Theranostics 2019 1;9(1):65-76. Epub 2019 Jan 1.

Key Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Chronic nonhealing diabetic wound therapy and complete skin regeneration remains a critical clinical challenge. The controlled release of bioactive factors from a multifunctional hydrogel was a promising strategy to repair chronic wounds. Herein, for the first time, we developed an injectable, self-healing and antibacterial polypeptide-based FHE hydrogel (F127/OHA-EPL) with stimuli-responsive adipose-derived mesenchymal stem cells exosomes (AMSCs-exo) release for synergistically enhancing chronic wound healing and complete skin regeneration. Read More

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http://www.thno.org/v09p0065.htm
Publisher Site
http://dx.doi.org/10.7150/thno.29766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332800PMC
January 2019
14 Reads

Antimicrobial and anti-inflammatory drug-delivery systems at endodontic reparative material: Synthesis and characterization.

Dent Mater 2019 Mar 11;35(3):457-467. Epub 2019 Jan 11.

Department of Conservative Dentistry, Dental Materials Laboratory, School of Dentistry, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2492, Porto Alegre, Rio Grande do Sul 90035-003, Brazil. Electronic address:

Objective: The aim of this study was to synthesize and characterize an experimental endodontic paste.

Methods: An experimental endodontic paste (EX) was characterized by its particle size, zeta potential, drug content and morphology. The powder of EX is composed of amoxicillin microspheres, calcium tungstate and α-tricalcium phosphate, mixed with an indomethacin nanocapsules suspension. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01095641183065
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http://dx.doi.org/10.1016/j.dental.2019.01.002DOI Listing
March 2019
9 Reads

Factors Associated With Patient-Initiated Communication After Mohs Micrographic Surgery.

Dermatol Surg 2019 02;45(2):234-243

Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Despite extensive counseling, patients commonly call with postoperative concerns after Mohs micrographic surgery (MMS).

Objective: We sought to determine the incidence, reasons, and patient and surgical characteristics that lead to patient-initiated communication after MMS.

Materials And Methods: A retrospective chart review of 1,531 patients who underwent MMS during the observational period was conducted. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001750DOI Listing
February 2019
3 Reads

Stage IV Perineal Pressure Ulcers in Immobile Patients Treated With Surgical Flap Closure Augmented With Cryopreserved Placental Membrane Containing Viable Cells.

Wounds 2019 Jan;31(1):15-18

Osiris Therapeutics, Inc, Columbia, MD.

Introduction: Surgical closure of late-stage pressure ulcers (PUs) poses challenges in the immobilized population due to the high rate of complications, including infection, dehiscence, and recurrence. Muscle flap closure is the standard treatment for chronic, late-stage (stage 4) PUs, characterized by the European Pressure Ulcer Advisory Panel and National Pressure Ulcer Advisory Panel as full-thickness tissue loss with exposure of bone, tendon, or muscle.

Objective: The aim of this study is to evaluate the outcomes associated with the use of a cryopreserved placental membrane containing viable cells (vCPM) graft for the augmentation of surgical flap closure in nonhealing perineal ulcers. Read More

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January 2019
16 Reads

Effect of One-Suture and Sutureless Techniques on Postoperative Healing After Third Molar Surgery.

J Oral Maxillofac Surg 2019 Apr 11;77(4):703.e1-703.e16. Epub 2018 Dec 11.

Professor and Chair, The National Maxillofacial Unit, St James's Hospital, Dublin, Ireland; Department of Oral and Maxillofacial Surgery, Dublin Dental University Hospital, Dublin, Ireland.

Purpose: The wound closure technique for lower third molar surgery (LTMS) is an operative factor that influences wound healing and the occurrence of early postoperative complications. The present study investigated 2 closure techniques (partial closure using 1 suture and the suture-less technique) after use of a modified buccal envelope flap for LTMS.

Materials And Methods: We performed a prospective, randomized, double-blind, split-mouth, controlled trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02782391183129
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http://dx.doi.org/10.1016/j.joms.2018.12.001DOI Listing
April 2019
9 Reads

A US hospital budget impact analysis of a skin closure system compared with standard of care in hip and knee arthroplasty.

Clinicoecon Outcomes Res 2019 17;11:1-11. Epub 2018 Dec 17.

Cornerstone Research Group Inc., Burlington, ON, Canada,

Background: Medicare's mandatory bundle for hip and knee arthroplasty necessitates provider accountability for quality and cost of care to 90 days, and wound closure may be a key area of consideration. The DERMABOND PRINEO Skin Closure System (22 cm) combines a topical skin adhesive with a self-adhering mesh without the need for dressing changes or suture or staple removal. This study estimated the budget impact of the Skin Closure System compared to other wound closure methods for hip and knee arthroplasty. Read More

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http://dx.doi.org/10.2147/CEOR.S181630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301301PMC
December 2018
7 Reads

Reconstructive Surgery of Inguinal Defects: A Systematic Literature Review of Surgical Etiology and Reconstructive Technique.

In Vivo 2019 Jan-Feb;33(1):1-9

Department of Plastic, Reconstructive and Hand Surgery, Lausanne University Hospital (CHUV), Lausanne, Switzerland

Background/aim: This study aimed to evaluate the literature regarding surgical etiology demanding inguinal reconstructive surgery, associated reconstructive techniques and outcomes.

Materials And Methods: A systematic literature search was performed according to the PRISMA statement between 1996-2016.

Results: A total of 64 articles were included, comprising 816 patients. Read More

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http://dx.doi.org/10.21873/invivo.11431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364081PMC

Vacuum-assisted wound closure and permanent onlay mesh-mediated fascial traction: A Novel Technique for the Prevention of Incisional Hernia after Open Abdomen Therapy Including Results From a Retrospective Case Series.

Scand J Surg 2018 Dec 21:1457496918818979. Epub 2018 Dec 21.

1 Department of Clinical Sciences, Malmö, Faculty of Medicine, Lund University, Lund, Sweden.

Background And Aims:: Incisional hernia development is a frequent long-term sequel after open abdomen treatment. This report describes a novel technique, the vacuum-assisted wound closure and permanent onlay mesh-mediated fascial traction for temporary and final closure of the open abdomen, with the intention to decrease incisional hernia rates. Primary aim was to evaluate incisional hernia development and secondary aims to describe short-term complications and patient-reported outcome. Read More

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http://dx.doi.org/10.1177/1457496918818979DOI Listing
December 2018
1 Read

Processed eggshell membrane powder: Bioinspiration for an innovative wound healing product.

Mater Sci Eng C Mater Biol Appl 2019 Feb 24;95:192-203. Epub 2018 Oct 24.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada; Department of Innovation in Medical Education, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1G 5Z3, Canada.. Electronic address:

Non-healing wounds are a major health problem worldwide and a significant cause of morbidity and mortality. Effective treatments for acute and chronic skin wounds are the focus of intensive research. Eggshell membrane (ESM) is a natural proteinaceous by-product of the food industry and is suitable for biomedical applications. Read More

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http://dx.doi.org/10.1016/j.msec.2018.10.054DOI Listing
February 2019
3 Reads

The effects of barbed suture on watertightness after knee arthrotomy closure: a cadaveric study.

J Orthop Surg Res 2018 Dec 20;13(1):323. Epub 2018 Dec 20.

Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

Background: Wound closure is one of the crucial aspects of total knee arthroplasty (TKA) for patients who perform high-flexion activities of daily living, because the joint capsule is highly stretched and integrity of the arthrotomy closure must be maintained. Watertightness of the knee joint is a different aspect of the repair integrity of arthrotomy closure and is being noticed with increasing usage of the drain clamp method for blood management after TKA. Recently, the barbed knotless suture has been growing in popularity as a strong, secure closure appropriate for high-tension areas, such as the fascia and joint capsule. Read More

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https://josr-online.biomedcentral.com/articles/10.1186/s1301
Publisher Site
http://dx.doi.org/10.1186/s13018-018-1035-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302503PMC
December 2018
10 Reads

Y-Peg-in-a-Round-Hole Closure for Immediate Periareolar Mastectomy Expander Reconstruction.

Ann Plast Surg 2019 Feb;82(2):145-151

Department of Plastic Surgery, St Vincent's Hospital, Melbourne.

Introduction: Mastectomies closed with a linear scar can distort the resulting shape of the breast. We present our novel Y-peg-in-a-round-hole closure method of the mastectomy scar, which improves the shape of the reconstructed breast while maintaining reliable healing, implant coverage, and minimum scar size for covering by tattoo.

Materials And Methods: A retrospective review of all breast reconstruction cases performed by the senior surgeon during the period from January 2010 to January 2017 was undertaken. Read More

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http://Insights.ovid.com/crossref?an=00000637-900000000-9713
Publisher Site
http://dx.doi.org/10.1097/SAP.0000000000001690DOI Listing
February 2019
12 Reads

Gap closure of different shape wounds: In vitro and in vivo experimental models in the presence of engineered protein adhesive hydrogel.

J Tissue Eng Regen Med 2019 Feb 25;13(2):174-178. Epub 2018 Dec 25.

Biological Materials Laboratory, Microbiology Division, CSIR-CLRI (Central Leather Reasearch Institute), Adyar, Chennai, India.

The present study emphasizes the role of engineered protein (gallic acid engineered gelatin [GEG]) on the closure of wound gaps of different shapes assessed under in vitro (fibroblast cell line) and in vivo (rat) experimental models. Circular, triangle, rectangle, and square are the shapes selected for the study. Intending engineered protein (GEG) augments the cell migration in rectangle and triangle shapes and reduces the gap space significantly compared with circular and square shapes. Read More

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http://dx.doi.org/10.1002/term.2779DOI Listing
February 2019
1 Read

Evaluation of antioxidant, diuretic, and wound healing effect of Tulkarm honey and its effect on kidney function in rats.

Vet World 2018 Nov 25;11(10):1491-1499. Epub 2018 Oct 25.

Laboratory of Physiology, Pharmacology and Environmental Health, Faculty of Sciences, Dhar El Mehraz, BP 1796 Atlas, University Sidi Mohamed Ben Abdallah, Fez 30 000, Morocco.

Aim: The composition and activity of honey depend on its floral origin. Honey collected from Tulkarm was evaluated for physicochemical property and antioxidant content as well as a diuretic and wound healing activity. Its effect on kidney function was evaluated and compared with furosemide. Read More

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http://www.veterinaryworld.org/Vol.11/October-2018/21.html
Publisher Site
http://dx.doi.org/10.14202/vetworld.2018.1491-1499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247886PMC
November 2018
3 Reads

Outcomes of an Esterified Hyaluronic Acid Matrix in the Treatment of Chronic Lower Extremity Wounds: A Case Series.

Wounds 2018 Dec;30(12):367-371

Center for Lower Extremity Ambulatory Research (CLEAR), Dr. William M. Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, IL.

Objective: This case series evaluates the outcomes of persons with chronic lower extremity wounds treated with an esterified hyaluronic acid matrix (EHAM).

Materials And Methods: Data were abstracted from 12 consecutive patients with a total of 14 evaluated chronic wounds (12 [100%] men, mean age 58.72 years) presenting for care at a multidisciplinary wound care center. Read More

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December 2018
1 Read