2,020 results match your criteria Materials for Wound Closure


Gap closure of different shape wounds: in vitro and in vivo experimental models in the presence of engineered protein adhesive hydrogel.

J Tissue Eng Regen Med 2018 Dec 7. Epub 2018 Dec 7.

Biological Materials Laboratory, Microbiology Division, CSIR-CLRI (Central Leather Reasearch Institute), Tamil Nadu, India.

The present study emphasizes the role of engineered protein (gallic acid engineered gelatin (GEG)) on the closure of wound gaps of different shapes assessed under in vitro (Fibroblast cell line) and in vivo (rat) experimental models. Circular, Triangle, Rectangle and Square are the shapes selected for the study. Intending engineered protein (GEG) augments the cell migration in rectangle and triangle shapes and reduces the gap space significantly compared to circular and square shapes. Read More

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http://dx.doi.org/10.1002/term.2779DOI Listing
December 2018

Evaluation of antioxidant, diuretic, and wound healing effect of Tulkarm honey and its effect on kidney function in rats.

Vet World 2018 Nov 25;11(10):1491-1499. Epub 2018 Oct 25.

Laboratory of Physiology, Pharmacology and Environmental Health, Faculty of Sciences, Dhar El Mehraz, BP 1796 Atlas, University Sidi Mohamed Ben Abdallah, Fez 30 000, Morocco.

Aim: The composition and activity of honey depend on its floral origin. Honey collected from Tulkarm was evaluated for physicochemical property and antioxidant content as well as a diuretic and wound healing activity. Its effect on kidney function was evaluated and compared with furosemide. Read More

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http://dx.doi.org/10.14202/vetworld.2018.1491-1499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247886PMC
November 2018

Outcomes of an Esterified Hyaluronic Acid Matrix in the Treatment of Chronic Lower Extremity Wounds: A Case Series.

Wounds 2018 Dec;30(12):367-371

Center for Lower Extremity Ambulatory Research (CLEAR), Dr. William M. Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, IL.

Objective: This case series evaluates the outcomes of persons with chronic lower extremity wounds treated with an esterified hyaluronic acid matrix (EHAM).

Materials And Methods: Data were abstracted from 12 consecutive patients with a total of 14 evaluated chronic wounds (12 [100%] men, mean age 58.72 years) presenting for care at a multidisciplinary wound care center. Read More

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December 2018

Synthetic mesh placement in the presence of abdominal infection: An experimental study of feasibility.

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):501-506

Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkey.

Background: There are varying opinions on the feasibility of the placement of synthetic materials in contaminated surgical fields. The aim of this study was to investigate the outcomes of the use of a commercially available composite mesh in the presence of abdominal infection.

Methods: Twenty-four hours after the induction of experimental peritonitis, 20 rats were randomized into 2 groups of 10 subjects. Read More

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November 2018
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Fabrication of juglone functionalized silver nanoparticle stabilized collagen scaffolds for pro-wound healing activities.

Int J Biol Macromol 2018 Nov 27;124:1002-1015. Epub 2018 Nov 27.

Biological Materials Laboratory, Council of Scientific and Industrial Research-CLRI, Chennai 20, India; Academy of Scientific and Innovative Research-CLRI, Chennai 20, India. Electronic address:

The effective wound management strategies depends on identification and manipulation of the molecular defects in the pathophysiology of wound. Poor vascularization, protease susceptibility and microbial invasion at wound site affect the early wound closure. Hence, an efficient wound dressing material needs to promote angiogenesis, control proteolytic activity and microbial attack. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.11.221DOI Listing
November 2018

Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators.

ACS Nano 2018 Nov 29. Epub 2018 Nov 29.

Department of Materials Science and Engineering , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.

Skin wound healing is a major health care issue. While electric stimulations have been known for decades to be effective for facilitating skin wound recovery, practical applications are still largely limited by the clumsy electrical systems. Here, we report an efficient electrical bandage for accelerated skin wound healing. Read More

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http://dx.doi.org/10.1021/acsnano.8b07038DOI Listing
November 2018
1 Read
12.881 Impact Factor

Use of Negative Pressure Wound Therapy With Instillation and a Novel Reticulated Open-cell Foam Dressing With Through Holes at a Level 2 Trauma Center.

Authors:
Lindsey Blalock

Wounds 2018 Nov 22. Epub 2018 Nov 22.

Integumetrix, Nashville, TN.

Introduction: Current wound treatment options for complex wounds include advanced wound therapies. One such treatment, negative pressure wound therapy (NPWT), has evolved to include automated instillation of topical wound solutions with a user-specified dwell time (NPWTi-d). A novel reticulated open-cell foam dressing with through holes (ROCF-CC) was developed to assist wound cleansing by removing thick wound exudate and infectious material. Read More

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November 2018

Silk-Based Biomaterials in Cutaneous Wound Healing: A Systematic Review.

Adv Skin Wound Care 2018 Dec;31(12):565-573

In the Department of Surgery and Interventional Science at University College London in the United Kingdom, Pragash Kamalathevan, MA (Cantab), MBBS (UK); Peng S Ooi, MBChB (UK); and Yew L Loo, MBChB (UK), are Burns, Plastic & Reconstructive Surgery Candidates. The authors have disclosed no financial relationships related to this article. Submitted April 23, 2018; accepted in revised form June 22, 2018.

Objective: Effective wound dressings should promote healing through cellular migration, neovascularization, and re-epithelialization. Silk fibroin (SF) and silk sericin (SS) are reported to have very good biocompatibility, excellent mechanical properties, and controlled biodegradability. This review investigates the use and performance of silk-based biomaterials in cutaneous wounds within in vitro, in vivo, and randomized controlled studies. Read More

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http://dx.doi.org/10.1097/01.ASW.0000546233.35130.a9DOI Listing
December 2018
2 Reads

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment.

J Vis Exp 2018 Nov 6(141). Epub 2018 Nov 6.

Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center;

Wound healing is a dynamic repair process and is the most complex biological process in human life. In response to burn injury, alterations in biological pathways impair the inflammation response, resulting in delayed wound healing. Impaired wound healing frequently occurs in patients with diabetes leading to unfavorable outcomes such as amputation. Read More

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https://www.jove.com/video/57942/severe-burn-injury-in-a-swi
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http://dx.doi.org/10.3791/57942DOI Listing
November 2018
2 Reads

Leaving Contaminated Trauma Laparotomy Wounds Open Reduces Wound Infections But Does Not Add Value.

J Surg Res 2018 Dec 23;232:450-455. Epub 2018 Jul 23.

Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: The incidence of surgical site infection (SSI) has become a key quality indicator following clean and clean/contaminated surgical procedures. In contrast, contaminated and dirty wounds have garnered little attention with this quality metric because of the expected higher complication incidence. We hypothesized that wound management strategies in this high-risk population vary significantly and might not add value to the overall care. Read More

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http://dx.doi.org/10.1016/j.jss.2018.05.083DOI Listing
December 2018
5 Reads

SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress.

Arch Biochem Biophys 2018 Nov 17;661:117-124. Epub 2018 Nov 17.

Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address:

Objective: Chronic wounds are a devastating complication of diabetes and can lead to amputations or even death. Current medical therapies are insufficient to accelerate its repair. The objective of this study was to explore the role of Sirtuin1 (SIRT1) in diabetic wounds. Read More

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http://dx.doi.org/10.1016/j.abb.2018.11.016DOI Listing
November 2018

TachoSil Dural Reconstruction in Extracranial-Intracranial Bypass Surgeries.

J Neurol Surg A Cent Eur Neurosurg 2018 Nov 15. Epub 2018 Nov 15.

Department of Neurosurgery, BG-Klinikum Bergmannstrost GmbH, Merseburger Straße 165, Halle 06112, Germany.

Background: Superficial temporal artery to middle cerebral artery (STA-MCA) bypass is a treatment option for hemodynamic insufficiency in the anterior cerebral circulation. Complications associated with extracranial-intracranial bypass surgeries are ischemic strokes caused by bypass failure, wound-healing disorders, and further issues from cerebrospinal fluid (CSF) leakage. CSF leakage can provide pathways for infection. Read More

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http://dx.doi.org/10.1055/s-0038-1675565DOI Listing
November 2018
1 Read

Ultrasonicated graphene oxide enhances bone and skin wound regeneration.

Mater Sci Eng C Mater Biol Appl 2019 Jan 25;94:484-492. Epub 2018 Sep 25.

Stem Cell Institute, Kangwon National University, Chuncheon, Gangwon 200-701, Republic of Korea; College of Veterinary Medicine, Kangwon National University, Chuncheon, Gangwon 200-701, Republic of Korea. Electronic address:

In the present study, we investigated the applications of ultrasonicated graphene oxide (UGO) for bone regeneration and skin wound healing. Ultrasonication of a GO suspension increased the dispersion and stability (by increasing the zeta potential) of the GO suspension. UGO has fewer oxygen-containing groups but still displays excellent water dispersion. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183034
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http://dx.doi.org/10.1016/j.msec.2018.09.051DOI Listing
January 2019
6 Reads

Environmentally Adaptable and Temperature-Selective Self-Healing Polymers.

Macromol Rapid Commun 2018 Nov 2:e1800689. Epub 2018 Nov 2.

Department of Applied Chemistry, Kyungpook National University, Daegu, 41566, Republic of Korea.

Development of polymeric materials capable of self-healing at low temperatures is an important issue since their mechanical strength and self-healing performance are often in conflict with each other. Herein, random copolymers with self-healing capability in a wide temperature range prepared from 2-(dimethylamino)ethyl methacrylate (DMAEMA), glyceryl monomethacrylate (GlyMA), and butyl methacrylate monomers via free-radical polymerization and subsequent cross-linking with hexamethylene diisocyanate are reported. Wound closure is facilitated by swelling below the lower critical solution temperature or by heating above the glass transition temperature (T ) of the polymer. Read More

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http://doi.wiley.com/10.1002/marc.201800689
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http://dx.doi.org/10.1002/marc.201800689DOI Listing
November 2018
4 Reads

Investigation of the intrinsic permeability of ice-templated collagen scaffolds as a function of their structural and mechanical properties.

Acta Biomater 2019 Jan 24;83:189-198. Epub 2018 Oct 24.

Cambridge Centre for Medical Materials, Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Rd, Cambridge CB3 0FS, UK. Electronic address:

Collagen scaffolds are widely used in a range of tissue engineering applications, both in vitro and in vivo, where their permeability to fluid flow greatly affects their mechanical and biological functionality. This paper reports new insights into the interrelationships between permeability, scaffold structure, fluid pressure and deformation in collagen scaffolds, focussing in particular on the degree of closure and the alignment of the pores. Isotropic and aligned scaffolds of different occlusivity were produced by ice templating, and were characterised in terms of their structure and mechanical properties. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061183063
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http://dx.doi.org/10.1016/j.actbio.2018.10.034DOI Listing
January 2019
6 Reads

Use of Cerium Oxide Nanoparticles Conjugated with MicroRNA-146a to Correct the Diabetic Wound Healing Impairment.

J Am Coll Surg 2018 Oct 22. Epub 2018 Oct 22.

Laboratory for Fetal and Regenerative Biology, Department of Surgery, School of Medicine, University of Colorado Denver - Anschutz Medical Campus and Colorado Children's Hospital, Aurora, CO. Electronic address:

Background: Diabetic wounds have become one of the most challenging public health issues of the 21st century, yet there is no effective treatment available. We have previously shown that the diabetic wound healing impairment is associated with increased inflammation and decreased expression of the regulatory microRNA miR-146a. We have conjugated miR-146a to cerium oxide nanoparticles (CNP-miR146a) to target reactive oxygen species (ROS) and inflammation. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.09.017DOI Listing
October 2018

High ligation of the anal fistula tract by lateral approach: A prospective cohort study on a modification of the ligation of the intersphincteric fistula tract (LIFT) technique.

Int J Surg 2018 Oct 19;60:9-14. Epub 2018 Oct 19.

Department of Coloproctology, Yang Hospital, Seoul, Republic of Korea.

Background: Ligation of the intersphincteric fistula tract (LIFT) is a sphincter-preserving operation for anal fistulas. Although it has advantages in preserving continence after surgery, it is difficult to perform owing to the narrow field of view. We performed a modified surgical procedure based on the LIFT to overcome these drawbacks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17439191183157
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http://dx.doi.org/10.1016/j.ijsu.2018.08.008DOI Listing
October 2018
63 Reads

Evaluation of early wound healing scales/indexes in oral surgery: A literature review.

Clin Implant Dent Relat Res 2018 Dec 15;20(6):1030-1035. Epub 2018 Oct 15.

Department of Oral and Maxillofacial Surgery, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.

Background: The quality of the healing response after oral and maxillofacial surgery (OMS) is influenced by the nature of the tissue disruption and the circumstances surrounding wound closure. The use of wound healing scales may help the surgeon anticipate and, when possible, intervene so that wound repair can progress favorably.

Materials And Methods: Studies reported in the OMS literature of the last 20 years that applied scales/indexes to monitor the wound healing process were reviewed. Read More

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http://dx.doi.org/10.1111/cid.12680DOI Listing
December 2018

Pse-T2, an Antimicrobial Peptide with High-Level, Broad-Spectrum Antimicrobial Potency and Skin Biocompatibility against Multidrug-Resistant Pseudomonas aeruginosa Infection.

Antimicrob Agents Chemother 2018 Dec 26;62(12). Epub 2018 Nov 26.

Department of Biomedical Sciences, Chosun University, Gwangju, Republic of Korea

Pseudin-2, isolated from the frog , exhibits potent antibacterial activity but also cytotoxicity. In an effort to develop clinically applicable antimicrobial peptides (AMPs), we designed pseudin-2 analogs with Lys substitutions, resulting in elevated amphipathic α-helical structure and cationicity. In addition, truncated analogs of pseudin-2 and Lys-substituted peptides were synthesized to produce linear 18-residue amphipathic α-helices, which were further investigated for their mechanism and functions. Read More

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http://dx.doi.org/10.1128/AAC.01493-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256760PMC
December 2018
1 Read

Application of polycaprolactone, chitosan, and collagen composite as a nanofibrous mat loaded with silver sulfadiazine and growth factors for wound dressing.

Artif Organs 2018 Oct 11. Epub 2018 Oct 11.

Cellular and Molecular Research Center-Department of Anatomical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Fabrication of nanofibrous biomaterials composed of natural and synthetic materials that incorporated with antibiotic and growth factors with controlled release manner is an attractive topic in wound healing. The purpose of this study was to prepare optimal composite of materials as biomimetic nanofibrous mats for application in wound healing. The mat was prepared of polycaprolactone (PCL) in the bottom, chitosan/poly ethylene oxide (Cs/PEO) in the middle, and PCL/collagen (PCL/Coll) in the top layer. Read More

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http://doi.wiley.com/10.1111/aor.13369
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http://dx.doi.org/10.1111/aor.13369DOI Listing
October 2018
1 Read
2.050 Impact Factor

Antibacterial and biodegradable tissue nano-adhesives for rapid wound closure.

Int J Nanomedicine 2018 27;13:5849-5863. Epub 2018 Sep 27.

Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China,

Background: Although various organic tissue adhesives designed to facilitate would healing are gaining popularity in diverse clinical applications, they present significant inherent limitations, such as rejection, infections, toxicity and/or excessive swelling. It is highly desirable to develop efficient, biocompatible and anti-bacterial tissue adhesives for skin wound healing.

Purpose: Inspired by the fact that inorganic nanoparticles can directly glue tissues through the "nanobridging effect", herein disulfide bond-bridged nanosilver-decorated mesoporous silica nanoparticles (Ag-MSNs) was constructed as an effective and safe tissue adhesive with antibacterial and degradable properties for wound closure and healing. Read More

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https://www.dovepress.com/antibacterial-and-biodegradable-ti
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http://dx.doi.org/10.2147/IJN.S177109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166764PMC
November 2018
7 Reads

New Continuous Barbed Suture Device with Stratafix for the Vaginal Stump in Laparoscopic Hysterectomy.

Gynecol Minim Invasive Ther 2018 Oct-Dec;7(4):167-171. Epub 2018 Sep 26.

Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.

Aims: Closure of the vaginal stump in total laparoscopic hysterectomy (TLH) performed by interrupted suture is time-consuming and requires sufficient experience. Stratafix (SF) is a new type of antibacterial monofilament absorbable suture which has multiple small anchors on the string surface. There is no information concerning the efficacy of SF for vaginal stump suture in minimally invasive hysterectomy. Read More

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http://dx.doi.org/10.4103/GMIT.GMIT_34_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172871PMC
September 2018
1 Read

Polysaccharide-based film loaded with vitamin C and propolis: A promising device to accelerate diabetic wound healing.

Int J Pharm 2018 Dec 6;552(1-2):340-351. Epub 2018 Oct 6.

Laboratório de Tecnologia e Desenvolvimento de Compósitos e Materiais Poliméricos (LaCoPol), Universidade Federal de Pelotas (UFPel), Campus Capão do Leão s/n, 96010-900 Pelotas, RS, Brazil. Electronic address:

Wound healing can be a painful and time-consuming process in patients with diabetes mellitus. In light of this, the use of wound healing devices could help to accelerate this process. Here, cellulose-based films loaded with vitamin C (VitC) and/or propolis (Prop), two natural compounds with attractive properties were engineered. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173183074
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http://dx.doi.org/10.1016/j.ijpharm.2018.10.009DOI Listing
December 2018
1 Read

Outcomes in Fournier's Gangrene Using Skin and Soft Tissue Sparing Flap Preservation Surgery for Wound Closure: An Alternative Approach to Wide Radical Debridement.

Wounds 2018 Oct;30(10):290-299

Wright State University, Boonshoft School of Medicine, Division of Plastic Surgery, Dayton, OH.

Introduction: Fournier's gangrene (FG) remains a forbidding necrotizing soft tissue infection (NSTI) that necessitates early recognition, prompt surgical excision, and goal-directed antibiotic therapy. Traditionally, surgical management has included wide radical excision for sepsis control, but this management often leaves large, morbid wounds that require complex wound coverage, prolonged hospitalizations, and/or delayed healing.

Objective: The purpose of this case series is to report the outcomes of FG using a surrogate approach of concurrent debridement of spared skin and soft tissue, negative pressure wound therapy (NPWT), and serial delayed primary closure (DPC). Read More

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October 2018
8 Reads

Operative Management of Abdominal Wound Dehiscence: Outcomes and Factors Influencing Time to Healing in Patients Undergoing Surgical Debridement With Primary Closure.

Wounds 2018 Nov 23;30(11):317-323. Epub 2018 Aug 23.

Department of Plastic Surgery, Georgetown University Hospital, Washington, DC.

Introduction: Plastic surgeons are often consulted by other surgical teams for management of wound dehiscence following abdominopelvic surgery.

Objective: The purpose of this study is to determine whether operative debridement and primary closure of abdominopelvic wounds are safe and expeditious for patients.

Materials And Methods: A retrospective analysis was conducted on a database of patients who underwent operative debridement and closure at a single institution between January 2011 and December 2015 for dehisced abdominal or pelvic wounds acquired from prior obstetric, gynecologic, transplant, plastic, or general surgery procedures. Read More

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November 2018
9 Reads

Suture choice to reduce occurrence of surgical site infection, hernia, wound dehiscence and sinus/fistula: a network meta-analysis.

Ann R Coll Surg Engl 2018 Oct 5:1-12. Epub 2018 Oct 5.

Department of Colorectal Surgery, Chelsea and Westminster Hospital , London , UK.

Background: There are many options and little guiding evidence when choosing suture types with which to close the abdominal wall fascia. This network meta-analysis investigated the effect of suture materials on surgical site infection, hernia, wound dehiscence and sinus/fistula occurrence after abdominal surgery. The aim was to provide clarity on whether previous recommendations on suture choice could be followed with confidence. Read More

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https://publishing.rcseng.ac.uk/doi/10.1308/rcsann.2018.0170
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http://dx.doi.org/10.1308/rcsann.2018.0170DOI Listing
October 2018
2 Reads

Efficacy of Dexmedetomidine Added to Ropivacaine Infilteration on Postoperative Pain following Spine Surgeries: A Randomized Controlled study.

Anesth Essays Res 2018 Jul-Sep;12(3):700-704

Department of Anaesthesia, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.

Context: With modern lifestyle, there has been a steep increase in the number of low back pain patients in clinical practice. Lumbar microdiscectomy is one of the most common surgeries performed for this problem. Postoperative pain management is extremely important aspect of such advanced surgical technique among which wound infiltration is an efficient method. Read More

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http://www.aeronline.org/text.asp?2018/12/3/700/240881
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http://dx.doi.org/10.4103/aer.AER_89_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157233PMC
October 2018
8 Reads

Surgical Endoscopic Vacuum-assisted Closure Therapy (EVAC) in Treating Anastomotic Leakages After Major Resective Surgery of Esophageal and Gastric Cancer.

Anticancer Res 2018 Oct;38(10):5581-5587

Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University, St. Andrea Hospital, Rome, Italy.

Background/aim: Endoscopic vacuum-assisted closure therapy (EVAC) is a promising new technique for repairing upper gastrointestinal defects of different etiologies. As of 2018, however, no standardized recommendation exists. This article reviewed EVAC in treating anastomotic leakage following major resective surgery of esophageal (EC) and gastric cancer (GC). Read More

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http://dx.doi.org/10.21873/anticanres.12892DOI Listing
October 2018
1 Read
1.870 Impact Factor

Preclosure spectroscopic differences between healed and dehisced traumatic wounds.

PLoS One 2018 27;13(9):e0204453. Epub 2018 Sep 27.

Department of Surgery, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center (USUHS-Walter Reed Surgery), Bethesda, Maryland, United States of America.

Background: The complexity and severity of traumatic wounds in military and civilian trauma demands improved wound assessment, before, during, and after treatment. Here, we explore the potential of 3 charge-coupled device (3CCD) imaging values to distinguish between traumatic wounds that heal following closure and those that fail. Previous studies demonstrate that normalized 3CCD imaging values exhibit a high correlation with oxygen saturation and allow for comparison of values between diverse clinical settings, including utilizing different equipment and lighting. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204453PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160065PMC
September 2018

ERK activating peptide, AES16-2M promotes wound healing through accelerating migration of keratinocytes.

Sci Rep 2018 Sep 26;8(1):14398. Epub 2018 Sep 26.

Institute of Convergence Science, Korea University, Anam-ro 145, Seongbuk-ku, Seoul, 02841, Republic of Korea.

Wound healing is an important issue that influences quality of life, and the need for products associated with wound healing is growing annually. New materials and therapies for skin wounds are being continuously researched and developed in order to increase treatment efficacy. Here, we show that the peptide AES16-2M comprised of five short amino acid sequences (REGRT) demonstrates efficacy in wound healing. Read More

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http://dx.doi.org/10.1038/s41598-018-32851-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158248PMC
September 2018

Body Wall Reconstruction for Conjoined Twins: Our Experience and Lessons Learned.

Ann Plast Surg 2018 Dec;81(6S Suppl 1):S66-S70

From the Department of Plastic Surgery, Union Hospital, and.

Background: Conjoined twinning is a rare congenital malformation, and the resultant huge body wall defects after separation of conjoined twins represent a real challenge to surgeons.

Methods: From 2004 to 2009, authors performed body wall reconstruction for 2 pairs of thoraco-omphalopagus twins and 1 pair of ischiopagus tetrapus twins. Before separation, the techniques of tissue expansion and tractive training were adopted to acquire sufficient skin for final coverage. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001609DOI Listing
December 2018
2 Reads

A meta-analysis of randomized trials comparing bovine pericardium and other patch materials for carotid endarterectomy.

J Vasc Surg 2018 10;68(4):1241-1256.e1

Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pa.

Objective: Patch angioplasty during carotid endarterectomy is commonly used to treat symptomatic and asymptomatic carotid artery stenosis. The objective of the present study was to compare the different patch materials that are currently available (synthetic vs venous vs bovine pericardium) in terms of short- and long-term outcomes.

Methods: This study was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines and eligible randomized control trials were identified through a comprehensive search of PubMed, Scopus, and Cochrane Central published until September 2017. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.07.023DOI Listing
October 2018
1 Read

Systematic Review and Meta-Analysis of Hard Tissue Outcomes of Alveolar Ridge Preservation.

Int J Oral Maxillofac Implants 2018 Sep/Oct;33(5):979-994

Purpose: Alveolar ridge preservation procedures have been advocated to minimize postextraction dimensional loss. There is a need for systematic analyses of clinical factors affecting the outcomes of these procedures in order to improve their clinical outcomes. This systematic review and meta-analysis aimed to assess the efficacy of alveolar ridge preservation procedures in terms of hard tissue dimensional changes and to determine clinical factors affecting outcomes of these procedures. Read More

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http://dx.doi.org/10.11607/jomi.6399DOI Listing
November 2018

Demonstration of the adhesive properties of the medium-chain-length polyhydroxyalkanoate produced by Pseudomonas chlororaphis subsp. aurantiaca from glycerol.

Int J Biol Macromol 2018 Sep 13. Epub 2018 Sep 13.

UCIBIO-REQUIMTE, Chemistry Department, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Portugal. Electronic address:

Pseudomonas chlororaphis subsp. aurantiaca (DSM 19603) was grown on crude glycerol from biodiesel production to produce a medium-chain-length polyhydroxyalkanoate (mcl-PHA), composed of 3-hydroxydodecanoate (43 ± 1.8 mol%), 3-hydroxydecanoate (29 ± 3. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.09.064DOI Listing
September 2018

Negative Pressure Wound Therapy of Open Abdomen and Definitive Closure Techniques After Decompressive Laparotomy: A Single-center Observational Prospective Study.

Wounds 2018 Aug 13. Epub 2018 Aug 13.

University of Medicine and Pharmacy of Tîrgu Mureș, Târgu Mureș, Romania.

Introduction: Open abdomen is a concept that was developed especially in relation to abdominal compartment syndrome (ACS).

Objective: This study presents the evolution and complications related to the management of the open abdomen after decompressive laparotomy, using a standardized method based on negative pressure wound therapy (NPWT).

Materials And Methods: This observational prospective study conducted over a 9-month period included 19 patients who underwent decompressive laparotomies for ACS. Read More

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August 2018
6 Reads

Soft Tissue Coverage of Complex Periprosthetic Defects in Patients With Total Knee Arthroplasty: Analysis of Factors That Influence Reconstructive and Functional Outcomes.

Wounds 2018 Jul 30. Epub 2018 Jul 30.

Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital, Washington, DC.

Introduction: Wound breakdown following total knee arthroplasty (TKA) increases the risk of device exposure, infection, and major amputation. Although a variety of options to facilitate coverage of compromised knee joint prostheses exist, the relative safety, efficacy, and functional impact of each has not been determined.

Objective: This study aims to identify those perioperative factors that influence reconstructive and functional outcomes in patients with periprosthetic TKA defects. Read More

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July 2018
4 Reads

Implantable Nanomedical Scaffold Facilitates Healing of Chronic Lower Extremity Wounds.

Wounds 2018 Aug;30(8):E77-E80

Acera Surgical, St Louis, MO.

Background: Chronic, nonhealing wounds are a growing health care problem in the United States, affecting more than 6.5 million patients annually.

Objective: This retrospective study evaluates the clinical efficacy and utility of an implantable nanomedical scaffold in the treatment of chronic, nonhealing lower extremity wounds in patients with multiple comorbidities. Read More

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August 2018
4 Reads

Mesh versus non-mesh for inguinal and femoral hernia repair.

Cochrane Database Syst Rev 2018 Sep 13;9:CD011517. Epub 2018 Sep 13.

Townsville Hospital, 100 Angus Smith Drive, Douglas, Queensland, Australia, 4814.

Background: This is an update of a Cochrane Review first published in 2001.Hernias are protrusions of all or part of an organ through the body wall that normally contains it. Groin hernias include inguinal (96%) and femoral (4%) hernias, and are often symptomatic with discomfort. Read More

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http://dx.doi.org/10.1002/14651858.CD011517.pub2DOI Listing
September 2018
3 Reads

A comparative study of immediate wound healing complications following cleft lip repair using either absorbable or non-absorbable skin sutures.

J Korean Assoc Oral Maxillofac Surg 2018 Aug 29;44(4):159-166. Epub 2018 Aug 29.

Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Lagos, Nigeria.

Objectives: The aim of the study was to compare wound healing complications following the use of either absorbable or non-absorbable sutures for skin closure in cleft lip repair.

Materials And Methods: This was a randomized controlled trial conducted at the Department of Oral and Maxillofacial Surgery, Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria. Sixty subjects who required either primary or secondary cleft lip repair and satisfied all the inclusion criteria were recruited and randomized into two groups (Vicryl group or Nylon group). Read More

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http://dx.doi.org/10.5125/jkaoms.2018.44.4.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117469PMC
August 2018
2 Reads

Autologous and Allogeneic Skin Cell Grafts in the Treatment of Severely Burned Patients: Retrospective Clinical Study.

Transplant Proc 2018 Sep 13;50(7):2179-2187. Epub 2018 Mar 13.

Dr Stanisław Sakiel Center for Burns Treatment, Siemianowice Śląskie, Poland; Department of Health Sciences, Technical-Humanistic Academy, Bielsko-Biała, Poland.

Background: Transplantation of skin cells (keratinocytes and fibroblasts) cultured in vitro is a method of choice for the treatment of severe and extensive burns in patients with a deficit of donor sites for free split-thickness skin grafts, and when the grave medical condition of the patient excludes the possibility of an operation under general anesthetic. Appropriate amounts of keratinocytes and/or fibroblasts cultured in vitro are grafted as a suspension in platelet-leukocyte-rich gel directly on the prepared acceptor site. Approximately 3 weeks are needed for autologous cell culture to grow. Read More

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http://dx.doi.org/10.1016/j.transproceed.2017.11.079DOI Listing
September 2018
7 Reads

Effect of 5% transdermal lidocaine patches on postoperative analgesia in dogs undergoing hemilaminectomy.

J Small Anim Pract 2018 Sep 2. Epub 2018 Sep 2.

Dick White Referrals, Station Farm - London Road, Six Mile Bottom, Cambridgeshire, CB8 0UH, UK.

Objectives: To investigate the effect of 5% lidocaine patches on postoperative analgesia in dogs undergoing hemilaminectomy.

Materials And Methods: Client-owned dogs undergoing hemilaminectomy for a single acute intervertebral thoracolumbar disc extrusion were enrolled in this prospective, randomised, blinded clinical trial. Following methadone administration, anaesthesia was induced with propofol, and maintained with isoflurane in oxygen and fentanyl infusion, in both groups. Read More

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http://doi.wiley.com/10.1111/jsap.12925
Publisher Site
http://dx.doi.org/10.1111/jsap.12925DOI Listing
September 2018
11 Reads

Does blue light restore human epidermal barrier function via activation of Opsin during cutaneous wound healing?

Lasers Surg Med 2018 Aug 31. Epub 2018 Aug 31.

Centre for Skin Sciences, Faculty of Life Sciences, University of Bradford, Bradford, United Kingdom.

Background And Objective: Visible light has beneficial effects on cutaneous wound healing, but the role of potential photoreceptors in human skin is unknown. In addition, inconsistency in the parameters of blue and red light-based therapies for skin conditions makes interpretation difficult. Red light can activate cytochrome c oxidase and has been proposed as a wound healing therapy. Read More

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http://dx.doi.org/10.1002/lsm.23015DOI Listing
August 2018
4 Reads

Optimal surgical management in kidney and pancreas transplantation to minimise wound complications: A systematic review and meta-analysis.

Ann Med Surg (Lond) 2018 Sep 18;33:24-31. Epub 2018 Aug 18.

Westmead Clinical School, Sydney Medical School, University of Sydney, NSW, 2145, Australia.

Background: Immunosuppression in transplant patients increases the risk of wound complications. However, an optimal surgical approach to kidney and pancreas transplantation can minimise this risk.

Materials And Methods: We performed a systematic review and meta-analysis to examine factors contributing to incisional hernia formation in kidney and pancreas transplant recipients. Read More

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http://dx.doi.org/10.1016/j.amsu.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108074PMC
September 2018
1 Read

Humic Acid Enhances Wound Healing in the Rat Palate.

Evid Based Complement Alternat Med 2018 1;2018:1783513. Epub 2018 Aug 1.

Department of Pathology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.

Introduction: Humic acid was previously shown to enhance cutaneous wound healing and show antibacterial properties; however, it has not been used for wound healing in the oral cavity. Thus, the goal of this study was the evaluation of the effect of the humic acid on the healing of excisional wounds in an experimental rat study.

Materials And Methods: A circular wound on mid-palatal surfaces was made on a total of 77 Wistar rats by using a 3-mm biopsy punch under anesthesia. Read More

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http://dx.doi.org/10.1155/2018/1783513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092992PMC

Biomaterial suture Vicryl Plus reduces wound-related complications.

Ther Clin Risk Manag 2018 13;14:1417-1421. Epub 2018 Aug 13.

Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China,

Objective: To compare the wound-related complications following craniotomy in patients with brain gliomas undergoing wound closure using either absorbable antibacterial Vicryl Plus suture or traditional braided silk suture.

Materials And Methods: Two hundred and forty-five patients undergoing craniotomy for supratentorial gliomas from January 1, 2011 to December 31, 2013 were retrospectively analyzed. We divided the patients into two groups: the Vicryl Plus group (using absorbable antibacterial Vicryl Plus suture) and the control group (using traditional braided silk suture). Read More

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http://dx.doi.org/10.2147/TCRM.S164658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095114PMC
August 2018
10 Reads
1.340 Impact Factor

Thermosensitive biomimetic polyisocyanopeptide hydrogels may facilitate wound repair.

Biomaterials 2018 Oct 30;181:392-401. Epub 2018 Jul 30.

Department of Orthodontics and Craniofacial Biology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands. Electronic address:

Changing wound dressings inflicts pain and may disrupt wound repair. Novel synthetic thermosensitive hydrogels based on polyisocyanopeptide (PIC) offer a solution. These gels are liquid below 16 °C and form gels beyond room temperature. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612183052
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http://dx.doi.org/10.1016/j.biomaterials.2018.07.038DOI Listing
October 2018
27 Reads
8.560 Impact Factor

Bio-guided fractionation and isolation of active component from Tragopogon graminifolius based on its wound healing property.

J Ethnopharmacol 2018 Nov 8;226:48-55. Epub 2018 Aug 8.

Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Ethnopharmacological Relevance: Tragopogon graminifolius (T. graminifolius) from Asteraceae family has been used as a remedy in Persian traditional medicine for the treatment of various disorders such as wound healing.

Aim Of The Study: The purpose of this study is to investigate the compounds of T. Read More

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http://dx.doi.org/10.1016/j.jep.2018.08.002DOI Listing
November 2018

Topical folinic acid enhances wound healing in rat model.

Adv Med Sci 2018 Sep 6;63(2):347-352. Epub 2018 Aug 6.

Department of Chemical Engineering, Faculty of Engineering, Afyon Kocatepe University, Afyonkarahisar, Turkey.

Purpose: Folic acid is an essential vitamin participating in DNA synthesis and repair. Recently folic acid has been shown to stimulate DNA-repair capacity in dermal fibroblasts in response to injury. Thus, the present study aimed to investigate the effects of topical folinic acid, a 5-formyl derivative of tetrahydrofolic acid, on wound healing using rat wound model. Read More

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http://dx.doi.org/10.1016/j.advms.2018.04.011DOI Listing
September 2018
12 Reads

Measurements of tension on wound edges after strip harvest surgery.

Authors:
Muhammad Ahmad

J Cosmet Dermatol 2018 Aug 9. Epub 2018 Aug 9.

Aesthetic Plastic Surgery & Hair Transplant Institute, Islamabad, Pakistan.

Objective: To measure the wound closure tension after strip surgery.

Materials And Methods: The study was conducted in a private setup on patients undergoing first hair restoration surgery. The donor strip was marked with the patient in sitting position after checking the vertical scalp mobility. Read More

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http://dx.doi.org/10.1111/jocd.12739DOI Listing
August 2018
5 Reads
1.000 Impact Factor

Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells.

Cell Rep 2018 Jul;24(4):895-908.e6

Department of Chemical and Biomolecular Engineering, Physical Sciences-Oncology Center and the Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address:

The role of primary cilia in mechanosensation is essential in endothelial cell (EC) shear responsiveness. Here, we find that venous, capillary, and progenitor ECs respond to shear stress in vitro in a cilia-dependent manner. We then demonstrate that primary cilia assembly in human induced pluripotent stem cell (hiPSC)-derived ECs varies between different cell lines with marginal influence of differentiation protocol. Read More

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http://dx.doi.org/10.1016/j.celrep.2018.06.083DOI Listing