2,052 results match your criteria Materials for Wound Closure


The influence of wound closure on graft stability: An in vitro comparison of different bone grafting techniques for the treatment of one-wall horizontal bone defects.

Clin Implant Dent Relat Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Oral- and Cranio-Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.

Objectives: The aim of this preclinical study was to analyze and compare different grafting techniques with respect to volume stability after wound closure.

Materials And Methods: Four different grafting techniques were evaluated in vitro for volume stability in a one-wall horizontal defect configuration. Group 1: guided bone regeneration (GBR) with collagen membrane, particulated xenograft; group 2: GBR with collagen membrane, particulated xenograft, pins; group 3: GBR with titanium-reinforced membrane, particulated xenograft, pins; group 4: autogenous block graft, particulated xenograft, collagen membrane. Read More

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http://dx.doi.org/10.1111/cid.12728DOI Listing
February 2019

To Evaluate the Efficacy and Effectiveness of N-butyl-2-cyanoacrylate glue (TRU SEAL) in Closure of Oral and Maxillofacial Laceration and Surgical Incisions.

J Maxillofac Oral Surg 2019 Mar 21;18(1):131-138. Epub 2018 Apr 21.

Mysuru, India.

Introduction: Effective wound closure is critical for minimizing wound complications and preventing wound dehiscence. The various wound closure techniques include staples, traditional nylon and skin sutures, subcuticular sutures, and skin adhesives. Currently topical skin adhesives are frequently being used. Read More

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http://dx.doi.org/10.1007/s12663-018-1111-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328818PMC

Buccal Fat Pad: A Useful Adjunct Flap in Cleft Palate Repair.

J Maxillofac Oral Surg 2019 Mar 5;18(1):40-45. Epub 2018 Mar 5.

2Department of Surgery, University of Sokoto, Sokoto, Nigeria.

Aim: The aim of the study is to describe the technique and also the outcome of using buccal fat pad (BFP) as an adjunct flap in cleft palate repair and to report the surgical outcome.

Materials And Methods: All the surgical repairs with BFP were done under general anaesthesia. The use of BFP was indicated in patients who needed a secondary palatal cleft repair, those with wide palatal clefts or patients whose primary palatal cleft repair was complicated intraoperatively by inadvertent tearing of the nasal mucosa. Read More

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http://dx.doi.org/10.1007/s12663-018-1100-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328837PMC

A Randomized Controlled Trial Comparing a Human Acellular Dermal Matrix Versus Conventional Care for the Treatment of Venous Leg Ulcers.

Authors:
Shawn Cazzell

Wounds 2019 Jan 31. Epub 2019 Jan 31.

Limb Preservation Platform, Valley Vascular Surgical Associates, Fresno, CA.

Introduction: Venous leg ulcers (VLUs) are often chronic and difficult to treat, which makes alternative options to conventional care necessary to improve ulcer healing rates. While human acellular dermal matrices (ADMs) have shown promise in treating diabetic foot ulcers, no comparative studies have been published regarding VLU treatment. Decellularized ADMs (D-ADMs) have been used successfully in the treatment of a wide variety of wound repairs and may be effective in treating VLUs. Read More

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January 2019
2 Reads

Defective Black Nano-Titania Thermogels for Cutaneous Tumor-Induced Therapy and Healing.

Nano Lett 2019 Feb 7. Epub 2019 Feb 7.

State Key Laboratory of High-Performance Ceramics and Superfine Microstructure , Shanghai Institute of Ceramics, Chinese Academy of Sciences , 1295 Dingxi Road , Shanghai 200050 , People's Republic of China.

Current challenges in cutaneous tumor therapy are healing the skin wounds resulting from surgical resection and eliminating possible residual tumor cells to prevent recurrence. To address this issue, bifunctional biomaterials equipped with effective tumor therapeutic capacity for skin cancers and simultaneous tissue regenerative ability for wound closure are highly recommended. Herein, we report an injectable thermosensitive hydrogel (named BT-CTS thermogel) with the integration of nanosized black titania (B-TiO, ∼50 nm) nanoparticles into a chitosan (CTS) matrix. Read More

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http://dx.doi.org/10.1021/acs.nanolett.9b00367DOI Listing
February 2019
1 Read

Effect of dual-drug-releasing micelle-hydrogel composite on wound healing in vivo in full-thickness excision wound rat model.

J Biomed Mater Res A 2019 Jan 31. Epub 2019 Jan 31.

School of Materials Science, Japan Advanced Institute of Science and Technology, Ishikawa, 923-1292, Japan.

Wound healing is a complex process involving an intricate cascade of body responses. A composite dressing that would effectively target different stages of wound healing and regeneration is urgently needed. In the current study, we tested the efficacy of a previously prepared micelle-hydrogel composite loaded with two drugs, in full-thickness excision wound model in rat. Read More

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http://doi.wiley.com/10.1002/jbm.a.36639
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http://dx.doi.org/10.1002/jbm.a.36639DOI Listing
January 2019
7 Reads

Effects of low-dose ketamine infusion on remifentanil-induced acute opioid tolerance and the inflammatory response in patients undergoing orthognathic surgery.

J Pain Res 2019 17;12:377-385. Epub 2019 Jan 17.

Department of Dental Anesthesiology and Pain Management, Tohoku University Hospital, Sendai, Miyagi, Japan,

Purpose: Remifentanil is associated with acute opioid tolerance that can lead to increased postoperative consumption of opioid analgesics. The purpose of this study was to determine whether a low dose of ketamine prevents remifentanil-induced acute opioid tolerance and affects the neutrophil-lymphocyte ratio (NLR), a newly recognized biomarker of inflammation.

Materials And Methods: Forty patients undergoing orthognathic surgery were enrolled in this prospective, randomized, double-blind study and randomly assigned to intraoperative administration of one of the following anesthetic regimens: high-dose remifentanil (0. Read More

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http://dx.doi.org/10.2147/JPR.S177098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342226PMC
January 2019

Negative-Pressure Wound Therapy in Infants and Children: A Population-Based Study.

J Surg Res 2019 Mar 30;235:560-568. Epub 2018 Nov 30.

Division of Plastic Surgery, Department of Surgery, Washington University, St. Louis, Missouri. Electronic address:

Background: Although the safety and benefits of negative-pressure wound therapy (NPWT) have been clearly demonstrated in the adult population, studies evaluating the safety and describing the use of NPWT in the pediatric population have been limited. Given this paucity, the goals of this study were to (1) evaluate the literature dedicated to NPWT use in infants and children and (2) leverage a population-level analysis to describe the experience of NPWT use in the pediatric population.

Materials And Methods: We performed a literature review and analyzed the Truven Health Analytics MarketScan Commercial Claims Databases from 2006 to 2014 to identify infants and children treated with NPWT. Read More

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http://dx.doi.org/10.1016/j.jss.2018.10.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364568PMC

Multifunctional Silicon-Carbon Nanohybrids Simultaneously Featuring Bright Fluorescence, High Antibacterial and Wound Healing Activity.

Small 2019 Jan 25:e1803200. Epub 2019 Jan 25.

Laboratory of Nanoscale Biochemical Analysis, Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, China.

In this work, a class of multifunctional silicon-carbon nanohybrids (designated as SiCNs), which simultaneously possess aqueous dispersibility, bright fluorescence (photoluminescence quantum yield [PLQY]: ≈28%), as well as high antibacterial and wound healing activity, is presented. Taking advantage of these unique merits, cell distribution and pharmacological behavior of the SiCNs is first investigated through tracking their strong and stable fluorescence. The high bacteria inhibition ability (≈82. Read More

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http://dx.doi.org/10.1002/smll.201803200DOI Listing
January 2019
4 Reads

Periplocin promotes wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase.

Phytomedicine 2018 Dec 11;57:72-83. Epub 2018 Dec 11.

Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Background: Periploca forrestii(PF) is mainly utilized for treatment of arthritis and traumatic injury historically. We had previously demonstrated that a fraction rich in cardiotonic steroids isolated from PF had the potential to facilitate wound healing. However, the exact material basis and mechanism of action responsible for wound healing is still unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183060
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http://dx.doi.org/10.1016/j.phymed.2018.12.015DOI Listing
December 2018
3 Reads

A Systematic Review of Suture Technologies in Total Knee Arthroplasty.

Surg Technol Int 2019 Jan 18;34. Epub 2019 Jan 18.

Department of Orthopaedic Surgery, Lenox Hill Hospital, Northwell Health, New York, New York.

Over time, various materials and techniques have been developed for superficial and deep wound closure. However, potential complications, such as infections and dehiscences, can still occur, driving the development of new closure modalities. As wound closure technology continues to advance and change, the need to continuously evaluate the current techniques and materials persists. Read More

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January 2019
9 Reads

Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration.

Theranostics 2019 1;9(1):65-76. Epub 2019 Jan 1.

Key Laboratory of Orthopedics of Zhejiang Province, Department of Orthopedics, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Chronic nonhealing diabetic wound therapy and complete skin regeneration remains a critical clinical challenge. The controlled release of bioactive factors from a multifunctional hydrogel was a promising strategy to repair chronic wounds. Herein, for the first time, we developed an injectable, self-healing and antibacterial polypeptide-based FHE hydrogel (F127/OHA-EPL) with stimuli-responsive adipose-derived mesenchymal stem cells exosomes (AMSCs-exo) release for synergistically enhancing chronic wound healing and complete skin regeneration. Read More

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http://www.thno.org/v09p0065.htm
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http://dx.doi.org/10.7150/thno.29766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332800PMC
January 2019
6 Reads

Antimicrobial and anti-inflammatory drug-delivery systems at endodontic reparative material: Synthesis and characterization.

Dent Mater 2019 Jan 11. Epub 2019 Jan 11.

Department of Conservative Dentistry, Dental Materials Laboratory, School of Dentistry, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2492, Porto Alegre, Rio Grande do Sul 90035-003, Brazil. Electronic address:

Objective: The aim of this study was to synthesize and characterize an experimental endodontic paste.

Methods: An experimental endodontic paste (EX) was characterized by its particle size, zeta potential, drug content and morphology. The powder of EX is composed of amoxicillin microspheres, calcium tungstate and α-tricalcium phosphate, mixed with an indomethacin nanocapsules suspension. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01095641183065
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http://dx.doi.org/10.1016/j.dental.2019.01.002DOI Listing
January 2019
4 Reads

Factors Associated With Patient-Initiated Communication After Mohs Micrographic Surgery.

Dermatol Surg 2019 Feb;45(2):234-243

Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Despite extensive counseling, patients commonly call with postoperative concerns after Mohs micrographic surgery (MMS).

Objective: We sought to determine the incidence, reasons, and patient and surgical characteristics that lead to patient-initiated communication after MMS.

Materials And Methods: A retrospective chart review of 1,531 patients who underwent MMS during the observational period was conducted. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001750DOI Listing
February 2019
2 Reads

Stage IV Perineal Pressure Ulcers in Immobile Patients Treated With Surgical Flap Closure Augmented With Cryopreserved Placental Membrane Containing Viable Cells.

Wounds 2019 Jan;31(1):15-18

Osiris Therapeutics, Inc, Columbia, MD.

Introduction: Surgical closure of late-stage pressure ulcers (PUs) poses challenges in the immobilized population due to the high rate of complications, including infection, dehiscence, and recurrence. Muscle flap closure is the standard treatment for chronic, late-stage (stage 4) PUs, characterized by the European Pressure Ulcer Advisory Panel and National Pressure Ulcer Advisory Panel as full-thickness tissue loss with exposure of bone, tendon, or muscle.

Objective: The aim of this study is to evaluate the outcomes associated with the use of a cryopreserved placental membrane containing viable cells (vCPM) graft for the augmentation of surgical flap closure in nonhealing perineal ulcers. Read More

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January 2019
7 Reads

Effect of One-Suture and Sutureless Techniques on Postoperative Healing After Third Molar Surgery.

J Oral Maxillofac Surg 2018 Dec 11. Epub 2018 Dec 11.

Professor and Chair, The National Maxillofacial Unit, St James's Hospital, Dublin, Ireland; and Department of Oral and Maxillofacial Surgery, Dublin Dental University Hospital, Dublin, Ireland.

Purpose: The wound closure technique for lower third molar surgery (LTMS) is an operative factor that influences wound healing and the occurrence of early postoperative complications. The present study investigated 2 closure techniques (partial closure using 1 suture and the suture-less technique) after use of a modified buccal envelope flap for LTMS.

Materials And Methods: We performed a prospective, randomized, double-blind, split-mouth, controlled trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02782391183129
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http://dx.doi.org/10.1016/j.joms.2018.12.001DOI Listing
December 2018
7 Reads

A US hospital budget impact analysis of a skin closure system compared with standard of care in hip and knee arthroplasty.

Clinicoecon Outcomes Res 2019 17;11:1-11. Epub 2018 Dec 17.

Cornerstone Research Group Inc., Burlington, ON, Canada,

Background: Medicare's mandatory bundle for hip and knee arthroplasty necessitates provider accountability for quality and cost of care to 90 days, and wound closure may be a key area of consideration. The DERMABOND PRINEO Skin Closure System (22 cm) combines a topical skin adhesive with a self-adhering mesh without the need for dressing changes or suture or staple removal. This study estimated the budget impact of the Skin Closure System compared to other wound closure methods for hip and knee arthroplasty. Read More

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http://dx.doi.org/10.2147/CEOR.S181630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301301PMC
December 2018
2 Reads

Vacuum-assisted wound closure and permanent onlay mesh-mediated fascial traction: A Novel Technique for the Prevention of Incisional Hernia after Open Abdomen Therapy Including Results From a Retrospective Case Series.

Scand J Surg 2018 Dec 21:1457496918818979. Epub 2018 Dec 21.

1 Department of Clinical Sciences, Malmö, Faculty of Medicine, Lund University, Lund, Sweden.

Background And Aims:: Incisional hernia development is a frequent long-term sequel after open abdomen treatment. This report describes a novel technique, the vacuum-assisted wound closure and permanent onlay mesh-mediated fascial traction for temporary and final closure of the open abdomen, with the intention to decrease incisional hernia rates. Primary aim was to evaluate incisional hernia development and secondary aims to describe short-term complications and patient-reported outcome. Read More

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http://dx.doi.org/10.1177/1457496918818979DOI Listing
December 2018
1 Read

The effects of barbed suture on watertightness after knee arthrotomy closure: a cadaveric study.

J Orthop Surg Res 2018 Dec 20;13(1):323. Epub 2018 Dec 20.

Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

Background: Wound closure is one of the crucial aspects of total knee arthroplasty (TKA) for patients who perform high-flexion activities of daily living, because the joint capsule is highly stretched and integrity of the arthrotomy closure must be maintained. Watertightness of the knee joint is a different aspect of the repair integrity of arthrotomy closure and is being noticed with increasing usage of the drain clamp method for blood management after TKA. Recently, the barbed knotless suture has been growing in popularity as a strong, secure closure appropriate for high-tension areas, such as the fascia and joint capsule. Read More

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https://josr-online.biomedcentral.com/articles/10.1186/s1301
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http://dx.doi.org/10.1186/s13018-018-1035-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302503PMC
December 2018
5 Reads

Y-Peg-in-a-Round-Hole Closure for Immediate Periareolar Mastectomy Expander Reconstruction.

Ann Plast Surg 2019 Feb;82(2):145-151

Department of Plastic Surgery, St Vincent's Hospital, Melbourne.

Introduction: Mastectomies closed with a linear scar can distort the resulting shape of the breast. We present our novel Y-peg-in-a-round-hole closure method of the mastectomy scar, which improves the shape of the reconstructed breast while maintaining reliable healing, implant coverage, and minimum scar size for covering by tattoo.

Materials And Methods: A retrospective review of all breast reconstruction cases performed by the senior surgeon during the period from January 2010 to January 2017 was undertaken. Read More

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http://Insights.ovid.com/crossref?an=00000637-900000000-9713
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http://dx.doi.org/10.1097/SAP.0000000000001690DOI Listing
February 2019
5 Reads

Gap closure of different shape wounds: In vitro and in vivo experimental models in the presence of engineered protein adhesive hydrogel.

J Tissue Eng Regen Med 2018 Dec 7. Epub 2018 Dec 7.

Biological Materials Laboratory, Microbiology Division, CSIR-CLRI (Central Leather Reasearch Institute), Adyar, Chennai, India.

The present study emphasizes the role of engineered protein (gallic acid engineered gelatin [GEG]) on the closure of wound gaps of different shapes assessed under in vitro (fibroblast cell line) and in vivo (rat) experimental models. Circular, triangle, rectangle, and square are the shapes selected for the study. Intending engineered protein (GEG) augments the cell migration in rectangle and triangle shapes and reduces the gap space significantly compared with circular and square shapes. Read More

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http://dx.doi.org/10.1002/term.2779DOI Listing
December 2018

Evaluation of antioxidant, diuretic, and wound healing effect of Tulkarm honey and its effect on kidney function in rats.

Vet World 2018 Nov 25;11(10):1491-1499. Epub 2018 Oct 25.

Laboratory of Physiology, Pharmacology and Environmental Health, Faculty of Sciences, Dhar El Mehraz, BP 1796 Atlas, University Sidi Mohamed Ben Abdallah, Fez 30 000, Morocco.

Aim: The composition and activity of honey depend on its floral origin. Honey collected from Tulkarm was evaluated for physicochemical property and antioxidant content as well as a diuretic and wound healing activity. Its effect on kidney function was evaluated and compared with furosemide. Read More

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http://www.veterinaryworld.org/Vol.11/October-2018/21.html
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http://dx.doi.org/10.14202/vetworld.2018.1491-1499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247886PMC
November 2018
2 Reads

Outcomes of an Esterified Hyaluronic Acid Matrix in the Treatment of Chronic Lower Extremity Wounds: A Case Series.

Wounds 2018 Dec;30(12):367-371

Center for Lower Extremity Ambulatory Research (CLEAR), Dr. William M. Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, IL.

Objective: This case series evaluates the outcomes of persons with chronic lower extremity wounds treated with an esterified hyaluronic acid matrix (EHAM).

Materials And Methods: Data were abstracted from 12 consecutive patients with a total of 14 evaluated chronic wounds (12 [100%] men, mean age 58.72 years) presenting for care at a multidisciplinary wound care center. Read More

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December 2018

Synthetic mesh placement in the presence of abdominal infection: An experimental study of feasibility.

Ulus Travma Acil Cerrahi Derg 2018 Nov;24(6):501-506

Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkey.

Background: There are varying opinions on the feasibility of the placement of synthetic materials in contaminated surgical fields. The aim of this study was to investigate the outcomes of the use of a commercially available composite mesh in the presence of abdominal infection.

Methods: Twenty-four hours after the induction of experimental peritonitis, 20 rats were randomized into 2 groups of 10 subjects. Read More

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http://dx.doi.org/10.5505/tjtes.2018.59263DOI Listing
November 2018
5 Reads

Fabrication of juglone functionalized silver nanoparticle stabilized collagen scaffolds for pro-wound healing activities.

Int J Biol Macromol 2019 Mar 27;124:1002-1015. Epub 2018 Nov 27.

Biological Materials Laboratory, Council of Scientific and Industrial Research-CLRI, Chennai 20, India; Academy of Scientific and Innovative Research-CLRI, Chennai 20, India. Electronic address:

The effective wound management strategies depends on identification and manipulation of the molecular defects in the pathophysiology of wound. Poor vascularization, protease susceptibility and microbial invasion at wound site affect the early wound closure. Hence, an efficient wound dressing material needs to promote angiogenesis, control proteolytic activity and microbial attack. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.11.221DOI Listing
March 2019
1 Read

Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators.

ACS Nano 2018 Nov 29. Epub 2018 Nov 29.

Department of Materials Science and Engineering , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.

Skin wound healing is a major health care issue. While electric stimulations have been known for decades to be effective for facilitating skin wound recovery, practical applications are still largely limited by the clumsy electrical systems. Here, we report an efficient electrical bandage for accelerated skin wound healing. Read More

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http://dx.doi.org/10.1021/acsnano.8b07038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307171PMC
November 2018
8 Reads
12.881 Impact Factor

Use of Negative Pressure Wound Therapy With Instillation and a Novel Reticulated Open-cell Foam Dressing With Through Holes at a Level 2 Trauma Center.

Authors:
Lindsey Blalock

Wounds 2019 Feb 22;31(2):55-58. Epub 2018 Nov 22.

Integumetrix, Nashville, TN.

Introduction: Current wound treatment options for complex wounds include advanced wound therapies. One such treatment, negative pressure wound therapy (NPWT), has evolved to include automated instillation of topical wound solutions with a user-specified dwell time (NPWTi-d). A novel reticulated open-cell foam dressing with through holes (ROCF-CC) was developed to assist wound cleansing by removing thick wound exudate and infectious material. Read More

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February 2019
1 Read

Effectiveness of fascial closure technique following percutaneous endovascular aneurysm repair.

Ann R Coll Surg Engl 2019 Jan 28;101(1):14-16. Epub 2018 Nov 28.

Northwick Park Hospital , London , UK.

Introduction: Percutaneous access and closure is commonly performed for patients undergoing endovascular aneurysm repair (EVAR). It has proven to be a safe and successful method of closure associated with fewer complications when compared with the traditional open technique. Fascial closure is an alternative technique that can be used for closure reducing the risks associated with the open technique. Read More

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http://dx.doi.org/10.1308/rcsann.2018.0200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303821PMC
January 2019
1 Read

Silk-Based Biomaterials in Cutaneous Wound Healing: A Systematic Review.

Adv Skin Wound Care 2018 Dec;31(12):565-573

In the Department of Surgery and Interventional Science at University College London in the United Kingdom, Pragash Kamalathevan, MA (Cantab), MBBS (UK); Peng S Ooi, MBChB (UK); and Yew L Loo, MBChB (UK), are Burns, Plastic & Reconstructive Surgery Candidates. The authors have disclosed no financial relationships related to this article. Submitted April 23, 2018; accepted in revised form June 22, 2018.

Objective: Effective wound dressings should promote healing through cellular migration, neovascularization, and re-epithelialization. Silk fibroin (SF) and silk sericin (SS) are reported to have very good biocompatibility, excellent mechanical properties, and controlled biodegradability. This review investigates the use and performance of silk-based biomaterials in cutaneous wounds within in vitro, in vivo, and randomized controlled studies. Read More

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http://dx.doi.org/10.1097/01.ASW.0000546233.35130.a9DOI Listing
December 2018
7 Reads

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment.

J Vis Exp 2018 Nov 6(141). Epub 2018 Nov 6.

Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center;

Wound healing is a dynamic repair process and is the most complex biological process in human life. In response to burn injury, alterations in biological pathways impair the inflammation response, resulting in delayed wound healing. Impaired wound healing frequently occurs in patients with diabetes leading to unfavorable outcomes such as amputation. Read More

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https://www.jove.com/video/57942/severe-burn-injury-in-a-swi
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http://dx.doi.org/10.3791/57942DOI Listing
November 2018
13 Reads

Leaving Contaminated Trauma Laparotomy Wounds Open Reduces Wound Infections But Does Not Add Value.

J Surg Res 2018 Dec 23;232:450-455. Epub 2018 Jul 23.

Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: The incidence of surgical site infection (SSI) has become a key quality indicator following clean and clean/contaminated surgical procedures. In contrast, contaminated and dirty wounds have garnered little attention with this quality metric because of the expected higher complication incidence. We hypothesized that wound management strategies in this high-risk population vary significantly and might not add value to the overall care. Read More

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http://dx.doi.org/10.1016/j.jss.2018.05.083DOI Listing
December 2018
13 Reads

SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress.

Arch Biochem Biophys 2019 Jan 17;661:117-124. Epub 2018 Nov 17.

Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address:

Objective: Chronic wounds are a devastating complication of diabetes and can lead to amputations or even death. Current medical therapies are insufficient to accelerate its repair. The objective of this study was to explore the role of Sirtuin1 (SIRT1) in diabetic wounds. Read More

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http://dx.doi.org/10.1016/j.abb.2018.11.016DOI Listing
January 2019
1 Read

TachoSil Dural Reconstruction in Extracranial-Intracranial Bypass Surgeries.

J Neurol Surg A Cent Eur Neurosurg 2019 Jan 15;80(1):39-43. Epub 2018 Nov 15.

Department of Neurosurgery, BG-Klinikum Bergmannstrost GmbH, Merseburger Straße 165, Halle 06112, Germany.

Background: Superficial temporal artery to middle cerebral artery (STA-MCA) bypass is a treatment option for hemodynamic insufficiency in the anterior cerebral circulation. Complications associated with extracranial-intracranial bypass surgeries are ischemic strokes caused by bypass failure, wound-healing disorders, and further issues from cerebrospinal fluid (CSF) leakage. CSF leakage can provide pathways for infection. Read More

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http://dx.doi.org/10.1055/s-0038-1675565DOI Listing
January 2019
6 Reads

Ultrasonicated graphene oxide enhances bone and skin wound regeneration.

Mater Sci Eng C Mater Biol Appl 2019 Jan 25;94:484-492. Epub 2018 Sep 25.

Stem Cell Institute, Kangwon National University, Chuncheon, Gangwon 200-701, Republic of Korea; College of Veterinary Medicine, Kangwon National University, Chuncheon, Gangwon 200-701, Republic of Korea. Electronic address:

In the present study, we investigated the applications of ultrasonicated graphene oxide (UGO) for bone regeneration and skin wound healing. Ultrasonication of a GO suspension increased the dispersion and stability (by increasing the zeta potential) of the GO suspension. UGO has fewer oxygen-containing groups but still displays excellent water dispersion. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183034
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http://dx.doi.org/10.1016/j.msec.2018.09.051DOI Listing
January 2019
9 Reads

Environmentally Adaptable and Temperature-Selective Self-Healing Polymers.

Macromol Rapid Commun 2018 Dec 2;39(24):e1800689. Epub 2018 Nov 2.

Department of Applied Chemistry, Kyungpook National University, Daegu, 41566, Republic of Korea.

Development of polymeric materials capable of self-healing at low temperatures is an important issue since their mechanical strength and self-healing performance are often in conflict with each other. Herein, random copolymers with self-healing capability in a wide temperature range prepared from 2-(dimethylamino)ethyl methacrylate (DMAEMA), glyceryl monomethacrylate (GlyMA), and butyl methacrylate monomers via free-radical polymerization and subsequent cross-linking with hexamethylene diisocyanate are reported. Wound closure is facilitated by swelling below the lower critical solution temperature or by heating above the glass transition temperature (T ) of the polymer. Read More

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http://doi.wiley.com/10.1002/marc.201800689
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http://dx.doi.org/10.1002/marc.201800689DOI Listing
December 2018
5 Reads

Investigation of the intrinsic permeability of ice-templated collagen scaffolds as a function of their structural and mechanical properties.

Acta Biomater 2019 Jan 24;83:189-198. Epub 2018 Oct 24.

Cambridge Centre for Medical Materials, Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Rd, Cambridge CB3 0FS, UK. Electronic address:

Collagen scaffolds are widely used in a range of tissue engineering applications, both in vitro and in vivo, where their permeability to fluid flow greatly affects their mechanical and biological functionality. This paper reports new insights into the interrelationships between permeability, scaffold structure, fluid pressure and deformation in collagen scaffolds, focussing in particular on the degree of closure and the alignment of the pores. Isotropic and aligned scaffolds of different occlusivity were produced by ice templating, and were characterised in terms of their structure and mechanical properties. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061183063
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http://dx.doi.org/10.1016/j.actbio.2018.10.034DOI Listing
January 2019
12 Reads

Use of Cerium Oxide Nanoparticles Conjugated with MicroRNA-146a to Correct the Diabetic Wound Healing Impairment.

J Am Coll Surg 2019 Jan 22;228(1):107-115. Epub 2018 Oct 22.

Laboratory for Fetal and Regenerative Biology, Department of Surgery, School of Medicine, University of Colorado Denver - Anschutz Medical Campus and Colorado Children's Hospital, Aurora, CO. Electronic address:

Background: Diabetic wounds have become one of the most challenging public health issues of the 21st century, yet there is no effective treatment available. We have previously shown that the diabetic wound healing impairment is associated with increased inflammation and decreased expression of the regulatory microRNA miR-146a. We have conjugated miR-146a to cerium oxide nanoparticles (CNP-miR146a) to target reactive oxygen species (ROS) and inflammation. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.09.017DOI Listing
January 2019
2 Reads

High ligation of the anal fistula tract by lateral approach: A prospective cohort study on a modification of the ligation of the intersphincteric fistula tract (LIFT) technique.

Int J Surg 2018 Dec 19;60:9-14. Epub 2018 Oct 19.

Department of Coloproctology, Yang Hospital, Seoul, Republic of Korea.

Background: Ligation of the intersphincteric fistula tract (LIFT) is a sphincter-preserving operation for anal fistulas. Although it has advantages in preserving continence after surgery, it is difficult to perform owing to the narrow field of view. We performed a modified surgical procedure based on the LIFT to overcome these drawbacks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17439191183157
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http://dx.doi.org/10.1016/j.ijsu.2018.08.008DOI Listing
December 2018
96 Reads

Evaluation of early wound healing scales/indexes in oral surgery: A literature review.

Clin Implant Dent Relat Res 2018 Dec 15;20(6):1030-1035. Epub 2018 Oct 15.

Department of Oral and Maxillofacial Surgery, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.

Background: The quality of the healing response after oral and maxillofacial surgery (OMS) is influenced by the nature of the tissue disruption and the circumstances surrounding wound closure. The use of wound healing scales may help the surgeon anticipate and, when possible, intervene so that wound repair can progress favorably.

Materials And Methods: Studies reported in the OMS literature of the last 20 years that applied scales/indexes to monitor the wound healing process were reviewed. Read More

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http://dx.doi.org/10.1111/cid.12680DOI Listing
December 2018
1 Read

Pse-T2, an Antimicrobial Peptide with High-Level, Broad-Spectrum Antimicrobial Potency and Skin Biocompatibility against Multidrug-Resistant Pseudomonas aeruginosa Infection.

Antimicrob Agents Chemother 2018 Dec 26;62(12). Epub 2018 Nov 26.

Department of Biomedical Sciences, Chosun University, Gwangju, Republic of Korea

Pseudin-2, isolated from the frog , exhibits potent antibacterial activity but also cytotoxicity. In an effort to develop clinically applicable antimicrobial peptides (AMPs), we designed pseudin-2 analogs with Lys substitutions, resulting in elevated amphipathic α-helical structure and cationicity. In addition, truncated analogs of pseudin-2 and Lys-substituted peptides were synthesized to produce linear 18-residue amphipathic α-helices, which were further investigated for their mechanism and functions. Read More

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http://dx.doi.org/10.1128/AAC.01493-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256760PMC
December 2018
2 Reads

PEG-Plasma Hydrogels Increase Epithelialization Using a Human Ex Vivo Skin Model.

Int J Mol Sci 2018 10 13;19(10). Epub 2018 Oct 13.

Combat Trauma and Burn Injury Research, US Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234-6315, USA.

In vitro cell culture methods are used extensively to study cellular migration, proliferation, and differentiation, which play major roles in wound healing but the results often do not translate to the in vivo environment. One alternative would be to establish an ex vivo model utilizing human discarded skin to evaluate therapies in a more natural setting. The purpose of this study was to institute such a model by creating 'wounds' in the center of a piece of discarded skin and treating them with three different biomaterials: collagen, polyethylene glycol (PEG)-fibrin, or PEG-platelet free plasma (PFP). Read More

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http://www.mdpi.com/1422-0067/19/10/3156
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http://dx.doi.org/10.3390/ijms19103156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213988PMC
October 2018
8 Reads

SIKVAV-Modified Chitosan Hydrogel as a Skin Substitutes for Wound Closure in Mice.

Molecules 2018 Oct 11;23(10). Epub 2018 Oct 11.

Department of Histology & Embryology and Medical Genetics, School of Basic Medical Sciences, Jiujiang University, Jiujiang 332000, China.

Skin wound healing is a complex and dynamic process that involves angiogenesis and growth factor secretion. Newly formed vessels can provide nutrition and oxygen for skin wound healing. Growth factors in skin wounds are important for keratinocytes and fibroblasts proliferation, epithelialization, extracellular matrix remodeling, and angiogenesis, which accelerate skin wound healing. Read More

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http://www.mdpi.com/1420-3049/23/10/2611
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http://dx.doi.org/10.3390/molecules23102611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222830PMC
October 2018
16 Reads

Application of polycaprolactone, chitosan, and collagen composite as a nanofibrous mat loaded with silver sulfadiazine and growth factors for wound dressing.

Artif Organs 2018 Oct 11. Epub 2018 Oct 11.

Cellular and Molecular Research Center-Department of Anatomical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Fabrication of nanofibrous biomaterials composed of natural and synthetic materials that incorporated with antibiotic and growth factors with controlled release manner is an attractive topic in wound healing. The purpose of this study was to prepare optimal composite of materials as biomimetic nanofibrous mats for application in wound healing. The mat was prepared of polycaprolactone (PCL) in the bottom, chitosan/poly ethylene oxide (Cs/PEO) in the middle, and PCL/collagen (PCL/Coll) in the top layer. Read More

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http://doi.wiley.com/10.1111/aor.13369
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http://dx.doi.org/10.1111/aor.13369DOI Listing
October 2018
1 Read
2.050 Impact Factor

Antibacterial and biodegradable tissue nano-adhesives for rapid wound closure.

Int J Nanomedicine 2018 27;13:5849-5863. Epub 2018 Sep 27.

Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China,

Background: Although various organic tissue adhesives designed to facilitate would healing are gaining popularity in diverse clinical applications, they present significant inherent limitations, such as rejection, infections, toxicity and/or excessive swelling. It is highly desirable to develop efficient, biocompatible and anti-bacterial tissue adhesives for skin wound healing.

Purpose: Inspired by the fact that inorganic nanoparticles can directly glue tissues through the "nanobridging effect", herein disulfide bond-bridged nanosilver-decorated mesoporous silica nanoparticles (Ag-MSNs) was constructed as an effective and safe tissue adhesive with antibacterial and degradable properties for wound closure and healing. Read More

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https://www.dovepress.com/antibacterial-and-biodegradable-ti
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http://dx.doi.org/10.2147/IJN.S177109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166764PMC
November 2018
10 Reads

New Continuous Barbed Suture Device with Stratafix for the Vaginal Stump in Laparoscopic Hysterectomy.

Gynecol Minim Invasive Ther 2018 Oct-Dec;7(4):167-171. Epub 2018 Sep 26.

Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.

Aims: Closure of the vaginal stump in total laparoscopic hysterectomy (TLH) performed by interrupted suture is time-consuming and requires sufficient experience. Stratafix (SF) is a new type of antibacterial monofilament absorbable suture which has multiple small anchors on the string surface. There is no information concerning the efficacy of SF for vaginal stump suture in minimally invasive hysterectomy. Read More

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http://dx.doi.org/10.4103/GMIT.GMIT_34_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172871PMC
September 2018
2 Reads

Polysaccharide-based film loaded with vitamin C and propolis: A promising device to accelerate diabetic wound healing.

Int J Pharm 2018 Dec 6;552(1-2):340-351. Epub 2018 Oct 6.

Laboratório de Tecnologia e Desenvolvimento de Compósitos e Materiais Poliméricos (LaCoPol), Universidade Federal de Pelotas (UFPel), Campus Capão do Leão s/n, 96010-900 Pelotas, RS, Brazil. Electronic address:

Wound healing can be a painful and time-consuming process in patients with diabetes mellitus. In light of this, the use of wound healing devices could help to accelerate this process. Here, cellulose-based films loaded with vitamin C (VitC) and/or propolis (Prop), two natural compounds with attractive properties were engineered. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173183074
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http://dx.doi.org/10.1016/j.ijpharm.2018.10.009DOI Listing
December 2018
1 Read

Outcomes in Fournier's Gangrene Using Skin and Soft Tissue Sparing Flap Preservation Surgery for Wound Closure: An Alternative Approach to Wide Radical Debridement.

Wounds 2018 Oct;30(10):290-299

Wright State University, Boonshoft School of Medicine, Division of Plastic Surgery, Dayton, OH.

Introduction: Fournier's gangrene (FG) remains a forbidding necrotizing soft tissue infection (NSTI) that necessitates early recognition, prompt surgical excision, and goal-directed antibiotic therapy. Traditionally, surgical management has included wide radical excision for sepsis control, but this management often leaves large, morbid wounds that require complex wound coverage, prolonged hospitalizations, and/or delayed healing.

Objective: The purpose of this case series is to report the outcomes of FG using a surrogate approach of concurrent debridement of spared skin and soft tissue, negative pressure wound therapy (NPWT), and serial delayed primary closure (DPC). Read More

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October 2018
22 Reads

The Flint Lock: A Novel Technique in Total Knee Arthroplasty Closure.

Am J Orthop (Belle Mead NJ) 2018 Sep;47(9)

University of Nebraska Medical Center, Omaha, NE.

Conventional interrupted sutures are traditionally used in extensor mechanism closure during total knee arthroplasty (TKA). In recent years, barbed suture has been introduced with the proposed benefits of decreased closure time and a watertight seal that is superior to interrupted sutures. Complication rates using barbed sutures and conventional interrupted sutures are similar. Read More

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http://dx.doi.org/10.12788/ajo.2018.0074DOI Listing
September 2018
14 Reads

Operative Management of Abdominal Wound Dehiscence: Outcomes and Factors Influencing Time to Healing in Patients Undergoing Surgical Debridement With Primary Closure.

Wounds 2018 Nov 23;30(11):317-323. Epub 2018 Aug 23.

Department of Plastic Surgery, Georgetown University Hospital, Washington, DC.

Introduction: Plastic surgeons are often consulted by other surgical teams for management of wound dehiscence following abdominopelvic surgery.

Objective: The purpose of this study is to determine whether operative debridement and primary closure of abdominopelvic wounds are safe and expeditious for patients.

Materials And Methods: A retrospective analysis was conducted on a database of patients who underwent operative debridement and closure at a single institution between January 2011 and December 2015 for dehisced abdominal or pelvic wounds acquired from prior obstetric, gynecologic, transplant, plastic, or general surgery procedures. Read More

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November 2018
13 Reads

Suture choice to reduce occurrence of surgical site infection, hernia, wound dehiscence and sinus/fistula: a network meta-analysis.

Ann R Coll Surg Engl 2018 Oct 5:1-12. Epub 2018 Oct 5.

Department of Colorectal Surgery, Chelsea and Westminster Hospital , London , UK.

Background: There are many options and little guiding evidence when choosing suture types with which to close the abdominal wall fascia. This network meta-analysis investigated the effect of suture materials on surgical site infection, hernia, wound dehiscence and sinus/fistula occurrence after abdominal surgery. The aim was to provide clarity on whether previous recommendations on suture choice could be followed with confidence. Read More

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https://publishing.rcseng.ac.uk/doi/10.1308/rcsann.2018.0170
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http://dx.doi.org/10.1308/rcsann.2018.0170DOI Listing
October 2018
4 Reads