2,303 results match your criteria Materials for Wound Closure


Incidence of Surgical Site Infections in Second Intention Healing After Dermatologic Surgery.

Dermatol Surg 2020 May 29. Epub 2020 May 29.

Department of Dermatology, Cooper Center for Dermatologic Surgery, Evesham, New Jersey.

Background: There are few studies analyzing the surgical site infection (SSI) rate of second intention wounds after dermatologic surgery, and the results are inconclusive. Yet, the current dogma in dermatologic surgery is that wounds healed by second intention have lower infection rates.

Objective: To determine the rate of SSI and associated pathogenic organisms of second intention wounds compared with sutured wounds after skin cancer extirpation. Read More

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http://dx.doi.org/10.1097/DSS.0000000000002409DOI Listing

Type I collagen matrix plus polyhexamethylene biguanide antimicrobial for the treatment of cutaneous wounds.

J Comp Eff Res 2020 Jun 1. Epub 2020 Jun 1.

Sabolinski LLC, Franklin, MA 02038, USA.

Determine the effectiveness of purified native type I collagen matrix plus polyhexamethylene biguanide antimicrobial (PCMP) on cutaneous wounds. A prospective cohort study of 307 patients (67 venous leg ulcers, 62 diabetic foot ulcers, 45 pressure ulcers, 54 postsurgical wounds and 79 other wounds) was conducted. Cox wound closure for PCMP was 73% at week 32. Read More

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http://dx.doi.org/10.2217/cer-2020-0058DOI Listing

Inpatient Versus Outpatient Management of Negative Pressure Wound Therapy in Pediatric Patients.

J Surg Res 2020 May 22;254:197-205. Epub 2020 May 22.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University, St. Louis, Missouri. Electronic address:

Background: Negative pressure wound therapy (NPWT) is commonly used to manage complex wounds in the pediatric population. With recently developed portable NPWT devices, providers have the opportunity to transition NPWT to the outpatient setting. However, there are no studies describing outpatient NPWT in pediatric patients. Read More

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http://dx.doi.org/10.1016/j.jss.2020.04.025DOI Listing

Thyroxine impregnated chitosan-based dressings stimulate angiogenesis and support fast wounds healing in rats: Potential clinical candidates.

Int J Biol Macromol 2020 May 18. Epub 2020 May 18.

Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, 54000, Pakistan. Electronic address:

This research paper demonstrates efficacy of chitosan and thyroxine loaded chitosan (CS) dressings for their angiogenic and wound healing potential. The dressings were prepared by freeze gelation method. Thyroxine was loaded by physical adsorption into chitosan membranes. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.05.127DOI Listing

Combined Endo-restorative Treatment of a Traumatized Central Incisor: A Five-year Follow-up.

J Adhes Dent 2020 ;22(3):249-254

Purpose: The management of complicated crown-root fractures is challenging for endodontic restoration. The present case describes a patient who sustained trauma to the maxillary right central incisor.

Materials And Methods: Clinical and radiographic examination showed a complicated crown-root fracture and incomplete root development with periapical radiolucency and inadequate endodontic treatment with overfilling. Read More

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http://dx.doi.org/10.3290/j.jad.a44548DOI Listing

Cosmetic outcomes and patient satisfaction compared between staples and subcuticular suture technique for wound closure after primary total knee arthroplasty: a randomized controlled trial.

Arch Orthop Trauma Surg 2020 May 18. Epub 2020 May 18.

Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Road, Bangkok Noi, Bangkok, 10700, Thailand.

Introduction: Staples and subcuticular suture are commonly used wound closure techniques after total knee arthroplasty (TKA). To date, only a few studies have investigated the differences between these two wound closure methods in TKA. Accordingly, this study aimed to compare cosmetic outcome and patient satisfaction between staples and subcuticular suture for post-TKA wound closure. Read More

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http://dx.doi.org/10.1007/s00402-020-03479-3DOI Listing

Wound healing properties of magnesium mineralized antimicrobial nanofibre dressings containing chondroitin sulphate - a comparison between blend and core-shell nanofibres.

Biomater Sci 2020 May 18. Epub 2020 May 18.

Anti-Infectives Research Group, Singapore Eye Research Institute, Singapore 169856, Singapore. and Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore 169857, Singapore and Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore.

The development of antimicrobial nanofibre dressings that can protect the injured tissues from commensal pathogens while promoting tissue regeneration finds enormous potential in plastic and reconstructive surgery practices. To achieve this goal, we investigated the effect of chondroitin sulphate on the morphology, mechanical properties, wettability and biocompatibility of polydopamine crosslinked electrospun gelatin nanofibres containing mineralized magnesium. To extend the durability of dressings, we prepared composite dressings containing polycaprolactone (PCL) and gelatin as blend or core-shell nanofibres. Read More

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http://dx.doi.org/10.1039/d0bm00530dDOI Listing

Electrospun fibers: an innovative delivery method for the treatment of bone diseases.

Expert Opin Drug Deliv 2020 May 19:1-13. Epub 2020 May 19.

Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.

: The treatment performances of current surgical therapeutic materials for injuries caused by high-energy trauma, such as prolonged bone defects, nerve-fiber disruptions, and repeated spasms or adhesions of vascular tendons after repair, are poor. Drug-loaded electrospun fibers have become a novel polymeric material for treating orthopedic diseases owing to their three-dimensional structures, thus providing excellent controlled drug-release responses and high affinity with local tissues. Herein, we reviewed the morphology of electrospun nanofibers, methods for loading drugs on the fibers, and modification methods to improve drug permeability and bioavailability. Read More

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http://dx.doi.org/10.1080/17425247.2020.1767583DOI Listing

Injectable Antimicrobial Conductive Hydrogels for Wound Disinfection and Infectious Wound Healing.

Biomacromolecules 2020 May;21(5):1841-1852

Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.

As the abuse of antibiotics continues to increase, the emergence of antibiotic resistance and unknown drug-resistant bacterial infections pose a great threat on people worldwide. In this work, we aimed to develop a series of injectable antimicrobial conductive hydrogels based on glycidyl methacrylate functionalized quaternized chitosan (QCSG), gelatin methacrylate (GM), and graphene oxide (GO) for drug-resistant bacterial disinfection and infectious wound healing. The rheology, morphology, mechanical properties, and electrical and photothermal properties of the hydrogels were characterized. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b01732DOI Listing

Open abdomen closure methods for severe abdominal sepsis: a retrospective cohort study.

Eur J Trauma Emerg Surg 2020 May 6. Epub 2020 May 6.

Department of General Surgery, San Giovanni Addolorata Hospital, Rome, Italy.

Purpose: The open abdomen (OA) procedure as part of damage control surgery represents a significant surgical advance in severe intra-abdominal infections. Major techniques used for OA are negative pressure wound therapy (NPWT) and non-NPWT. The aim of this retrospective study is to evaluate the effects of different abdominal closure methods and their outcomes in patients presenting with abdominal sepsis treated with OA. Read More

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http://dx.doi.org/10.1007/s00068-020-01379-0DOI Listing

Osteoblasts migration, attachment and human bone marrow-mesenchymal stem cells osteogenic differentiation towards surface engineered and growth factors conjugated poly(lactic acid) microspheres.

J Mater Sci Mater Med 2020 May 4;31(5):45. Epub 2020 May 4.

Biomaterials Niche Group, School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, 14300, Nibong Tebal, Pulau Pinang, Malaysia.

Recently, surface engineered biomaterials through surface modification are extensively investigated due to its potential to enhance cellular homing and migration which contributes to a successful drug delivery process. This study is focused on osteoblasts response towards surface engineered using a simple sodium hydroxide (NaOH) hydrolysis and growth factors conjugated poly(lactic acid) (PLA) microspheres. In this study, evaluation of the relationship of NaOH concentration with the molecular weight changes and surface morphology of PLA microspheres specifically wall thickness and porosity prior to in vitro studies was investigated. Read More

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http://dx.doi.org/10.1007/s10856-020-06380-yDOI Listing

Injectable Click Chemistry-based Bioadhesives for Accelerated Wound Closure.

Acta Biomater 2020 Apr 30. Epub 2020 Apr 30.

Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA. Electronic address:

Tissue adhesives play a vital role in surgical processes as a substitute for sutures in wound closure. However, several existing tissue adhesives suffer from cell toxicity, weak tissue-adhesive strength, and high cost. In this study, by taking advantage of the fast and specific inverse-demand Diels-Alder cycloaddition reaction, a series of bioadhesives were produced by employing copper-free click chemistry pair trans-cyclooctene (TCO) /tetrazine (Tz) in chitosan. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.04.004DOI Listing

Palatal Wound Healing with Primary Intention in a Rat Model-Histology and Immunohistomorphometry.

Medicina (Kaunas) 2020 Apr 24;56(4). Epub 2020 Apr 24.

Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dental Medicine, Tel Aviv University, Tel-Aviv 69978, Israel.

Background And Objectives: Subepithelial connective tissue graft (SCTG) from the palate has been considered as the "gold standard" for the treatment of deep gingival recessions. A single-incision technique was reported to allow primary wound healing. A palatal single incision was performed in a rat model. Read More

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http://dx.doi.org/10.3390/medicina56040200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230352PMC

The dynamics of closure following excisional mid-palatal mucoperiosteal wound in a rat model.

Clin Oral Investig 2020 Apr 24. Epub 2020 Apr 24.

Department of Periodontology and Oral Implantology, The Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: The aim of the present study was to assess macroscopically the time-related dimensional pattern of excisional palatal mucoperiosteal wound closure in rats, concomitantly with microscopic analysis of the density of inflammatory infiltrate and myofibroblasts.

Materials And Methods: Excisional palatal wounds, 4.2 mm in diameter, were made in twenty-one 2-month-old male Wistar rats. Read More

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http://dx.doi.org/10.1007/s00784-020-03304-6DOI Listing

Chitosan-glucan complex hollow fibers reinforced collagen wound dressing embedded with aloe vera. II. Multifunctional properties to promote cutaneous wound healing.

Int J Pharm 2020 May 18;582:119349. Epub 2020 Apr 18.

CEITEC-Central European Institute of Technology, Brno University of Technology, Purkyňova 656/123, Brno 612 00, Czechia; SCITEG, a.s., Brno, Czechia; Institute of Materials Chemistry, Facility of Chemistry, Brno University of Technology, Purkyňova 464/118, Brno 612 00, Czechia.

This study presents an innovative multifunctional system in fabricating new functional wound dressing (FWD) products that could be used for skin regeneration, especially in cases of infected chronic wounds and ulcers. The innovation is based on the extraction, characterization, and application of collagen (CO)/chitosan-glucan complex hollow fibers (CSGC)/aloe vera (AV) as a novel FWS. For the first time, specific hollow fibers were extracted with controlled inner (500-900 nm)/outer (2-3 µm) diameters from mycelium of Schizophyllum commune. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119349DOI Listing
May 2020
3.650 Impact Factor

Neurosurgical Post-Operative Wound Infections: A retrospective study on surgical site infections for quality improvement.

Int Wound J 2020 Apr 21. Epub 2020 Apr 21.

Department of Neurosurgery, Desert Regional Medical Center, Palm Springs, California, USA.

Despite efforts to maintain a meticulous aseptic environment, wound infection is one of the most common complications following surgery and may be related to dehiscence, haemorrhage, infection, and/or poor surgical technique. With the appearance of new wound closure techniques and suture materials, we felt compelled to perform a retrospective study on our institution's neurosurgical population to determine how our institution compared to others in terms of incidence of surgical site infection (SSI). A retrospective analysis was performed at our single institution for all patients that had cranial or spine surgery by a neurosurgeon for the past 15 years. Read More

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http://dx.doi.org/10.1111/iwj.13367DOI Listing

The recent progress of tissue adhesives in design strategies, adhesive mechanism and applications.

Mater Sci Eng C Mater Biol Appl 2020 Jun 5;111:110796. Epub 2020 Mar 5.

CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao 266101, China. Electronic address:

Tissue adhesives have emerged as an effective method for wound closure and hemostasis in recent decades, due to their ability to bond tissues together, preventing separation from one tissue to another. However, existing tissue adhesives still have several limitations. Tremendous efforts have been invested into developing new tissue adhesives by improving upon existing adhesives through different strategies. Read More

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http://dx.doi.org/10.1016/j.msec.2020.110796DOI Listing

Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application.

Int J Nanomedicine 2020 20;15:1939-1950. Epub 2020 Mar 20.

State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, The College of Life Science, Nankai University, Tianjin, People's Republic of China.

Introduction: Chronic trauma repair is an important issue affecting people's healthy lives. Thermo-sensitive hydrogel is injectable in situ and can be used to treat large-area wounds. In addition, antioxidants play important roles in promoting wound repair. Read More

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http://dx.doi.org/10.2147/IJN.S235609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094004PMC

Zwitterionic poly(sulfobetaine methacrylate) hydrogels with optimal mechanical properties for improving wound healing in vivo.

J Mater Chem B 2019 03 8;7(10):1697-1707. Epub 2019 Feb 8.

College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325027, P. R. China.

Zwitterionic hydrogels, as highly hydrated and soft materials, have been considered as promising materials for wound dressing, due to their unique antifouling and mechanical properties. While the viscoelasticity and softness of zwitterionic hydrogels are hypothetically essential for creating adaptive cellular niches, the underlying mechanically regulated wound healing mechanism still remains elusive. To test this hypothesis, we fabricated zwitterionic poly(sulfobetaine methacrylate) (polySBMA) hydrogels with different elastic moduli prepared at different crosslinker contents, and then applied the hydrogels to full-thickness cutaneous wounds in mice. Read More

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http://dx.doi.org/10.1039/c8tb02590hDOI Listing

Sinusectomy and primary closure versus excision and primary closure in pilonidal sinus disease: a retrospective cohort study.

Int J Colorectal Dis 2020 Jun 4;35(6):1117-1124. Epub 2020 Apr 4.

Department of General Surgery, Bezmialem Vakıf University School of Medicine, 34000, Istanbul, Turkey.

Background: Various surgical procedures are available for the treatment of pilonidal sinus diseases (PSD), but the best surgical approach remains controversial. Minimally invasive surgical procedures are more popular than surgery. This study aimed to evaluate the efficacy of sinusectomy with primary closure (SPC) in comparison with excision and primary closure (EPC) in primary or recurrent cases. Read More

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http://dx.doi.org/10.1007/s00384-020-03575-1DOI Listing

Mesenchymal stromal cells from dermal and adipose tissues induce macrophage polarization to a pro-repair phenotype and improve skin wound healing.

Cytotherapy 2020 May 29;22(5):247-260. Epub 2020 Mar 29.

Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil; National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil. Electronic address:

The process of wound healing restores skin homeostasis but not full functionality; thus, novel therapeutic strategies are needed to accelerate wound closure and improve the quality of healing. In this context, tissue engineering and cellular therapies are promising approaches. Although sharing essential characteristics, mesenchymal stromal cells (MSCs) isolated from different tissues might have distinct properties. Read More

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http://dx.doi.org/10.1016/j.jcyt.2020.02.003DOI Listing

Resveratrol inhibits ACHN cells via regulation of histone acetylation.

Pharm Biol 2020 Dec;58(1):231-238

Department of Encephalopathy, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

The relationship between resveratrol and histone acetylation in renal cell carcinoma (RCC) has not yet been reported. To explore the functional role of resveratrol in RCC. Functional experiments were performed to determine proliferatio n of ACHN cells with treatment of resveratrol (0, 7. Read More

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http://dx.doi.org/10.1080/13880209.2020.1738503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144206PMC
December 2020

Pressure reducing skin pie-crusting in extremity trauma: An in-vitro biomechanical study and human case series.

Injury 2020 Mar 4. Epub 2020 Mar 4.

Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri, USA. Electronic address:

Background: Multiple small relaxing skin incisions oriented parallel to the longitudinal axis (so-called "pie-crusting") near traumatic lacerations or surgical incisions in edematous tissue beds have been utilized to achieve primary closure when edema or skin loss would otherwise have made this difficult. Our study hopes to demonstrate (1) biomechanical evidence that pie-crusting decreases wound closure tension and (2) provide a case series with data showing clinical results.

Materials And Methods: This study is a biomechanical cadaveric study and retrospective small series cohort using 16 porcine limbs and 7 patients with 8 wounds in which pie-crusting was performed. Read More

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http://dx.doi.org/10.1016/j.injury.2020.03.008DOI Listing

Lily steroidal glycoalkaloid promotes early inflammatory resolution in wounded human fibroblasts.

J Ethnopharmacol 2020 Aug 17;258:112766. Epub 2020 Mar 17.

Department of Food Science, University of Tennessee Institute of Agriculture, Knoxville, TN, 37996, USA. Electronic address:

Ethnopharmacological Relevance: The bulbs and flowers of plants from the Lilium genus have historically been used in Asian and Greco-Roman medicine to treat burns and promote skin healing.

Aim Of The Study: To evaluate a steroidal glycoalkaloid isolated from Easter lily bulbs for its potential wound healing promoting properties.

Materials And Methods: A lily-derived steroidal glycoalkaloid (LSGA), (22R, 25R)-spirosol-5-en-3β-yl O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside, was isolated from Easter lily bulbs, and its structure was confirmed by LC-MS and NMR spectrometry. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112766DOI Listing

Multifunctional Antimicrobial Nanofiber Dressings Containing ε-Polylysine for the Eradication of Bacterial Bioburden and Promotion of Wound Healing in Critically Colonized Wounds.

ACS Appl Mater Interfaces 2020 Apr 27;12(14):15989-16005. Epub 2020 Mar 27.

Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856 Singapore.

Bacterial colonization of acute and chronic wounds is often associated with delayed wound healing and prolonged hospitalization. The rise of multi-drug resistant bacteria and the poor biocompatibility of topical antimicrobials warrant safe and effective antimicrobials. Antimicrobial agents that target microbial membranes without interfering with the mammalian cell proliferation and migration hold great promise in the treatment of traumatic wounds. Read More

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http://dx.doi.org/10.1021/acsami.9b21683DOI Listing

Percutaneous Closure of Gastrostomy Using a Suture-Mediated Vascular Closure Device in a Swine Model.

Cardiovasc Intervent Radiol 2020 May 12;43(5):781-786. Epub 2020 Mar 12.

Department of Radiology, Korea University Anam Hospital, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Purpose: After any procedure through the percutaneous gastrostomy (PG), a PG tube should be kept in place until a mature tract develops. For this period of maturation which takes about 2 to 4 weeks, tube dislodgement, leakage, or peritonitis can occur. Complications from PG tube maintenance can be prevented by closing the PG immediately after the procedure. Read More

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http://dx.doi.org/10.1007/s00270-020-02450-4DOI Listing

Topical Oxygen Therapy Shifts Microbiome Dynamics in Chronic Diabetic Foot Ulcers.

Wounds 2020 Mar;32(3):81-85

Division of Plastic Surgery, St. Michael's Hospital, Toronto, Canada; Faculty of Dentistry, University of Toronto, Toronto, Canada.

Introduction: Bacterial biofilm in wounds prevents healing by acting as a physical barrier to wound closure and hyperactivating local inflammatory processes, thus making its removal a high priority. The authors previously have shown that adding topical oxygen to standard wound care increased healing of Texas Grade II and III diabetic foot ulcers (DFUs), which they hypothesized was a result of alterations of the wound microbiome/biofilm.

Objective: This study aims to determine the mechanism of action of topical oxygen in DFUs by examining the diversity of bacterial genera present in DFUs treated with topical oxygen. Read More

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Comparing intra-oral wound healing after alveoloplasty using silk sutures and n-butyl-2-cyanoacrylate.

J Korean Assoc Oral Maxillofac Surg 2020 Feb 26;46(1):28-35. Epub 2020 Feb 26.

Department of Oral and Maxillofacial Surgery, Dr. D. Y. Patil Vidyapeeth, Pune, India.

Objectives: The need for proper wound closure is of paramount importance after any intra-oral surgery. Various wound closure techniques have been described in literature using traditional non-absorbable suture materials. These include like synthetic absorbable sutures, surgical staples and tissue adhesives. Read More

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http://dx.doi.org/10.5125/jkaoms.2020.46.1.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049767PMC
February 2020

Surgical Management of Lower Extremity Pyoderma Gangrenosum With Viable Cryopreserved Umbilical Tissue: A Case Series.

Wounds 2020 Feb 27. Epub 2020 Feb 27.

New York-Presbyterian Queens, Flushing, NY.

Introduction: Pyoderma gangrenosum (PG) is a rare skin disease that often presents as a uniquely painful and necrotic ulceration of the lower extremity. Pyoderma gangrenosum is often misdiagnosed and can have deleterious consequences to the patient, as there is no gold standard treatment and it can be difficult to manage. Surgery for these wounds is controversial, as pathergy can develop, worsening the ulceration. Read More

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February 2020

Intraabdominal Lavage of Hypochlorous Acid: A New Paradigm for the Septic and Open Abdomen.

Wounds 2020 Jan 23. Epub 2020 Jan 23.

University of North Texas, Denton, TX.

Introduction: Management of the open abdomen (OA) has rapidly evolved over the last several decades due to the improved understanding of the underlying pathophysiology of patients with an OA, adoption of damage control surgery, and the use of temporary abdominal closure (TAC) techniques for this patient population. The TAC utilizing negative pressure has been successful for managing patients with an OA with improved time to closure. Recent studies have started to examine the use of TAC in conjunction with negative pressure wound therapy with instillation and dwell time (NPWTi-d) for the management of the OA. Read More

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January 2020

Hidden blood loss in direct anterior total hip arthroplasty: a prospective, double blind, randomized controlled trial on topical versus intravenous tranexamic acid.

Musculoskelet Surg 2020 Mar 10. Epub 2020 Mar 10.

Department of Orthopaedic Surgery, University Hospitals Leuven - Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium.

Background: Despite a plethora of literature reporting on the use of tranexamic acid (TXA) in total hip arthroplasty (THA), little is available on its effect on post-operative hidden blood loss and even less on its use in the direct anterior approach (DAA), which is gaining popularity.

Materials And Methods: This study was designed as a prospective, double blind, single centre, randomized controlled trial. Sixty patients were allocated to intravenous administration of 1. Read More

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http://dx.doi.org/10.1007/s12306-020-00652-0DOI Listing

Diabetes alters the involvement of myofibroblasts during periodontal wound healing.

Oral Dis 2020 Mar 8. Epub 2020 Mar 8.

School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Objectives: Myofibroblasts constitute a specific cell phenotype involved in connective tissue healing. Diabetes alters the wound healing response. However, it is not clear whether diabetes modifies the involvement of myofibroblasts in periodontal wounds. Read More

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http://dx.doi.org/10.1111/odi.13325DOI Listing

Barbed sutures reduce arthrotomy closure duration compared to interrupted conventional sutures for total knee arthroplasty: a randomized controlled trial.

Musculoskelet Surg 2020 Mar 7. Epub 2020 Mar 7.

Department of Orthopedic Surgery, Cleveland Clinic, A41, 9500 Euclid Ave, Cleveland, OH, 44195, USA.

Background: The broad aim of this study was to compare the safety and efficacy of using barbed sutures versus standard-of-care sutures for closure of arthrotomy during total knee arthroplasty. Specifically, we compared the duration of arthrotomy closure, the number of sutures utilized for arthrotomy closure, and 90-day outcomes, including wound-related readmission, reoperation, and complications.

Materials And Methods: A total of 60 patients undergoing primary total knee arthroplasty were enrolled in a prospective, blinded trial and randomized to receive either running closure of the arthrotomy with barbed sutures (n = 30) or interrupted closure with standard-of-care sutures (n = 30). Read More

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http://dx.doi.org/10.1007/s12306-020-00654-yDOI Listing

Cytocompatibility and cell proliferation evaluation of calcium phosphate-based root canal sealers.

Restor Dent Endod 2020 Feb 15;45(1):e2. Epub 2019 Nov 15.

Departament of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

Objectives: This study aimed to evaluate the cell viability and migration of Endosequence Bioceramic Root Canal Sealer (BC Sealer) compared to MTA Fillapex and AH Plus.

Materials And Methods: BC Sealer, MTA Fillapex, and AH Plus were placed in contact with culture medium to obtain sealers extracts in dilution 1:1, 1:2 and 1:4. 3T3 cells were plated and exposed to the extracts. Read More

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http://dx.doi.org/10.5395/rde.2020.45.e2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030964PMC
February 2020

Investigation of the effects of thrombocyte-rich plasma, systemic ozone and hyperbaric oxygen treatment on intraoral wound healing in rats: experimental study.

Eur Arch Otorhinolaryngol 2020 Jun 27;277(6):1771-1777. Epub 2020 Feb 27.

Department of Otolaryngology, University of Health Sciences Bagcilar Training and Research Hospital, Istanbul, Turkey.

Objective: In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-rich plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats.

Materials And Methods: In this study, thirty-six Wistar Hannover rats with weight of 250-350 g, fed with standard feeds, were anesthetized to create intraoral wound on the hard palate. Rats were divided into four groups as the following: control group, PRP, HBO and Ozone groups. Read More

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http://dx.doi.org/10.1007/s00405-020-05872-5DOI Listing

Heat-treated human platelet pellet lysate modulates microglia activation, favors wound healing and promotes neuronal differentiation .

Platelets 2020 Feb 27:1-12. Epub 2020 Feb 27.

Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.

The neurorestorative efficacy of human platelet lysates in neurodegenerative disorders is still under investigation. Platelets prepared from standard and pathogen reduced platelet concentrates were pelletized, washed, concentrated, and subjected to freeze-thawing. The lysate was heated to 56°C for 30 min and characterized. Read More

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http://dx.doi.org/10.1080/09537104.2020.1732324DOI Listing
February 2020

MiRNA-875-3p alleviates the progression of colorectal cancer via negatively regulating PLK1 level.

Eur Rev Med Pharmacol Sci 2020 Feb;24(3):1126-1133

Department of General Surgery, Xi'an Central Hospital, Xi'an, China.

Objective: To clarify the expression pattern of miRNA-875-3p in CRC and its potential regulatory effect on the progression of CRC.

Materials And Methods: MiRNA-875-3p level in 56 matched CRC tissues and adjacent normal tissues were determined. The correlation between the miRNA-875-3p level and pathological indexes of CRC patients was analyzed. Read More

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http://dx.doi.org/10.26355/eurrev_202002_20163DOI Listing
February 2020

Establish an Cell Model to Explore the Impacts of UVA on Human Corneal Endothelial Wound Healing.

Curr Eye Res 2020 Feb 23:1-9. Epub 2020 Feb 23.

Laboratory for Corneal Tissue Engineering, College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong Province, China.

: To provide scientific data for clinical practice in making strategies for accelerating corneal endothelial wound healing, we investigated the impact of UVA on the corneal endothelial wound healing process and the underlying mechanism using an cell model.: An cell model for corneal endothelial wound healing was established by scratching the cultured human corneal endothelial cell (HCEnC) confluent layer. Then, we investigated the impacts of UVA irradiation and Ascorbic acid-2-phosphate (Asc-2p) on the wound healing process of the HCEnC model by examining wound-healing index, F-actin rate, Ki-67 rate, and ROS production. Read More

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http://dx.doi.org/10.1080/02713683.2020.1718166DOI Listing
February 2020

Accelerating healing of excisional wound with alginate hydrogel containing naringenin in rat model.

Drug Deliv Transl Res 2020 Feb 21. Epub 2020 Feb 21.

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Wounds have always been considered as one of the most common physical damages. Therefore, various researches have been conducted to find an appropriate method to improve wound healing process. Among various materials, since hydrogels have appropriate properties for wound healing, they are widely used for this purpose. Read More

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http://dx.doi.org/10.1007/s13346-020-00731-6DOI Listing
February 2020

Anti-Infective and Pro-Coagulant Chitosan-Based Hydrogel Tissue Adhesive for Sutureless Wound Closure.

Biomacromolecules 2020 Mar 19;21(3):1243-1253. Epub 2020 Feb 19.

Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, People's Republic of China.

Multifunctional tissue adhesives with excellent adhesion, antibleeding, anti-infection, and wound healing properties are desperately needed in clinical surgery. However, the successful development of multifunctional tissue adhesives that simultaneously possess all these properties remains a challenge. We have prepared a novel chitosan-based hydrogel adhesive by integration of hydrocaffeic acid-modified chitosan (CS-HA) with hydrophobically modified chitosan lactate (hmCS lactate) and characterized its gelation time, mechanical properties, and microstructure. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b01707DOI Listing

Primary wound closure and perioperative antibiotic therapy for prevention of bisphosphonate-related osteonecrosis of the jaw after tooth extraction.

Quintessence Int 2020 ;51(3):220-228

Objectives: Tooth extractions are suspected to be a major trigger for the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Preventive measures like perioperative antibiotic therapy and primary wound closure have been found to be effective in preventing the development of BRONJ following tooth extraction. The aim of this study was to present long-term results of a treatment protocol for patients under bisphosphonate therapy requiring tooth extraction. Read More

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http://dx.doi.org/10.3290/j.qi.a43949DOI Listing
February 2020

Temporary Abdominal Closure Technique After Pediatric Liver Transplant: Single-Center Experience.

Exp Clin Transplant 2020 Jan;18(Suppl 1):32-35

From the Department of Transplantation, Baskent University, Ankara, Turkey.

Objectives: Primary abdominal wound closure is performed at the completion of liver transplant in most patients. However, this is not always possible in pediatric recipients. The shortage of size-matched donor organs for pediatric patients means that occasionally it is necessary to use whole livers that are larger than can be accommodated comfortably in the child's abdomen. Read More

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http://dx.doi.org/10.6002/ect.TOND-TDTD2019.O6DOI Listing
January 2020

Wound complication among different skin closure techniques in the emergency cesarean section: a randomized control trial.

Obstet Gynecol Sci 2020 Jan 23;63(1):27-34. Epub 2019 Dec 23.

Department of Obstetrics and Gynecology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objective: Cesarean section is the most commonly performed obstetrical surgical procedure; however, there are no standard guidelines on appropriate skin closure techniques and materials. Only few comparative studies have been conducted on different skin closure techniques, and they have shown conflicting results. Therefore, we compared different skin closure techniques during emergency cesarean section to identify the best technique with minimal wound complication rates. Read More

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http://dx.doi.org/10.5468/ogs.2020.63.1.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962586PMC
January 2020

Socket preservation using eggshell-derived nanohydroxyapatite with platelet-rich fibrin as a barrier membrane: a new technique.

J Korean Assoc Oral Maxillofac Surg 2019 Dec 26;45(6):332-342. Epub 2019 Dec 26.

Department of Oral and Maxillofacial Pathology, Sibar Institute of Dental Sciences, Guntur, India.

Objectives: Socket grafting is vital to prevent bone resorption after tooth extraction. Several techniques to prevent resorption have been described, and various bone graft substitutes have been developed and used with varying success. We conducted this pilot study to evaluate the performance of nanohydroxyapatite (nHA) derived from chicken eggshells in socket preservation. Read More

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http://dx.doi.org/10.5125/jkaoms.2019.45.6.332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955417PMC
December 2019

The efficacy of a traditional medicine preparation on second-degree burn wounds in rats.

J Ethnopharmacol 2020 Apr 14;252:112570. Epub 2020 Jan 14.

Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:

Ethnopharmacological Relevance: Lime Salve (L.S) has been well documented from the 9th to the 19th century AD by traditional Iranian medicine (TIM) as an effective remedy for burn healing.

Aim Of The Study: The present study was undertaken to evaluate the healing effect and related underlying mechanisms of Lime Salve in a model of deep second-degree thermal burn in male Wistar rats. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112570DOI Listing

Performance of polyvinyl pyrrolidone-isatis root antibacterial wound dressings produced in situ by handheld electrospinner.

Colloids Surf B Biointerfaces 2020 Apr 28;188:110766. Epub 2019 Dec 28.

Industrial Research Institute of Nonwovens & Technical Textiles, College of Textiles & Clothing, Qingdao University, Qingdao, 266071, China; Collaborative Innovation Center for Eco-Textiles of Shandong Province, Qingdao University, Qingdao, 266071, China; Collaborative Innovation Center for Nanomaterials & Optoelectronic Devices, College of Physics, Qingdao University, Qingdao, 266071, China.

Antibacterial dressings are an increasingly important tool for the prevention and management of wound infections, particularly in light of concerns surrounding conventional drug-resistant antibiotics. Handheld electrospinning devices provide opportunities for the rapid application of antibacterial dressing materials to wounds, but spinning formulations need to be compatible with live biological surfaces. We report the development of a new antibacterial formulation compatible with handheld electrospinning, and its manufacture directly on a wound site. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.110766DOI Listing
April 2020
4.152 Impact Factor

Immobilization of Antimicrobial Silver and Antioxidant Flavonoid as a Coating for Wound Dressing Materials.

Int J Nanomedicine 2019 17;14:9929-9939. Epub 2019 Dec 17.

Department of Biomedical Engineering, International University, Vietnam National University- Ho Chi Minh City (VNU-HCM), Ho Chi Minh City 70000, Vietnam.

Purpose: The aim of this study is to develop a new coating for wound dressings that is comprised of antimicrobial silver (Ag) and antioxidant flavonoid quercetin (Q).

Methods: Dip-coating was used to apply the coating on cotton gauge as a model dressing. Ag was immobilised using polydopamine as a priming and catalytic layer followed by coating of quercetin that was incorporated in a functionalized polydimethylsiloxane. Read More

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http://dx.doi.org/10.2147/IJN.S230214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926368PMC

Magnesium oxide-crosslinked low-swelling citrate-based mussel-inspired tissue adhesives.

Biomaterials 2020 Feb 23;232:119719. Epub 2019 Dec 23.

Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA. Electronic address:

Tissue adhesives are commonly used in surgeries and regenerative engineering for the repair and regeneration of topical and internal wounds on tissues and organs such as skin, heart, blood vessels, and bone. However, achieving rapid crosslinking, strong wet adhesion and cohesion strengths, and minimal cytotoxicity remains a critical roadblock for clinical translation. Herein, in contrast to harsh and cytotoxic oxidants, magnesium oxide (MgO) particles were found to facilitate rapid crosslinking for injectable citrate-based mussel-inspired tissue bioadhesives synthesized by reacting citric acid, PEG-PPG-PEG diol and dopamine (iC-EPE). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.119719DOI Listing
February 2020

Moist-Retaining, Self-Recoverable, Bioadhesive, and Transparent in Situ Forming Hydrogels To Accelerate Wound Healing.

ACS Appl Mater Interfaces 2020 Jan 2;12(2):2023-2038. Epub 2020 Jan 2.

Department of Orthopedics , Shanghai Tenth People's Hospital Affiliated to Tongji University , 301 Yanchang Road , Shanghai 200072 , China.

In the management of accelerating wound healing, moist environments play an important role. Compared with other scaffolds of various forms, hydrogels can maintain a moist environment in the wound area. They are cross-linked hydrophilic polymeric networks that resemble natural soft tissues and extracellular matrices. Read More

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http://dx.doi.org/10.1021/acsami.9b17180DOI Listing
January 2020
6.723 Impact Factor