258 results match your criteria Marchiafava-Bignami Disease


Left hemispatial neglect with a splenial lesion.

Neurocase 2018 Aug 28;24(4):220-226. Epub 2018 Oct 28.

d Neurology Service and GRECC , Malcom Randall Veterans Affairs Medical Center , Gainesville , FL , USA.

With injury of the anterior two-thirds of the corpus callosum, each hemisphere's attentional bias to contralateral hemispace becomes manifest with each hand deviating ipsilaterally during line bisection tasks. Patients with infarctions in the right posterior cerebral artery distribution with occipital and splenial damage can also exhibit spatial neglect. The goal of this report is to learn the role of the splenium of the corpus callosum in mediating visuospatial attention. Read More

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https://www.tandfonline.com/doi/full/10.1080/13554794.2018.1
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http://dx.doi.org/10.1080/13554794.2018.1539501DOI Listing
August 2018
19 Reads

Bilateral middle cerebellar peduncles involvement a malnourished man with Marchiafava-Bignami disease.

Neurol Sci 2018 Oct 18. Epub 2018 Oct 18.

Department of Neurology, The Affiliated Hospital of Jiujiang University, No.57 Xunyang East Rode, Xunyang District, Jiujiang, 332000, Jiangxi Province, People's Republic of China.

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http://link.springer.com/10.1007/s10072-018-3608-7
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http://dx.doi.org/10.1007/s10072-018-3608-7DOI Listing
October 2018
6 Reads

A Case of Nonalcoholic Marchiafava-Bignami Disease with Left-Right Differential Agraphia of Chinese Characters.

Case Rep Neurol 2018 May-Aug;10(2):232-241. Epub 2018 Aug 29.

Department of Rehabilitation Medicine, Fukui General Hospital, Fukui City, Japan.

We report a 68-year-old right-handed female who was admitted to our hospital complaining chiefly of incontinence and decreased activity. Her brain images showed characteristics of Marchiafava-Bignami disease, such as symmetrical abnormal signals localized in the corpus callosum. The patient had no drinking habits. Read More

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https://www.karger.com/Article/FullText/492528
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http://dx.doi.org/10.1159/000492528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167702PMC
August 2018
1 Read

Marchiafava-Bignami Disease Presenting as Acute Psychosis.

Indian J Psychol Med 2018 Sep-Oct;40(5):494-496

Department of Psychiatry, Jamaica Hospital Center, Jamaica, New York, USA.

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_56_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149298PMC
October 2018

Rapidly Resolving Nonalcoholic Marchiafava-Bignami Disease in the Setting of Malnourishment After Gastric Bypass Surgery.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618784318. Epub 2018 Jun 28.

Augusta University, Augusta, GA, USA.

We describe a rare case of nonalcoholic Marchiafava-Bignami disease (MBD) in the setting of malnourishment after gastric bypass. A 44-year-old nonalcoholic Caucasian woman with malnutrition after gastric bypass presented with 2 weeks of weakness. The patient acutely became stuporous. Read More

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http://dx.doi.org/10.1177/2324709618784318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062771PMC

Reversible "ears of the lynx" sign in Marchiafava-Bignami disease.

Acta Neurol Belg 2018 Jul 16. Epub 2018 Jul 16.

Department of Neurology, Nîmes University Hospital, 4, Rue du Pr Debré, 30029, Nîmes Cedex 4, France.

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http://dx.doi.org/10.1007/s13760-018-0989-6DOI Listing

Marchiafava-Bignami Disease with Cortical Involvement.

Clin Lab 2018 Jun;64(6):1055-1059

Background: Marchiafava-Bignami disease (MBD) is a neurological degenerative disorder with a pathognomonic hallmark of symmetric demyelination in the corpus callosum (CC). Most reported cases were chronic alcoholics and some showed cortical lesions related to poor clinical prognosis. Herein we report a case of a chronic alcoholic who presented with confusion and generalized weakness. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.171220DOI Listing
June 2018
2 Reads

Marchiafava-Bignami disease.

Authors:
H Matsuura K Shindo

QJM 2018 Oct;111(10):755

Department of Neurology, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki-city, Okayama, Japan.

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http://dx.doi.org/10.1093/qjmed/hcy101DOI Listing
October 2018

Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease.

Neurocase 2018 Feb 26;24(1):59-67. Epub 2018 Feb 26.

c Neurology Service and GRECC , Malcom Randall Veterans Affairs Medical Center , Gainesville , FL , USA.

Apraxic agraphia can be caused by left hemispheric cerebral lesions in the area that contains the spatial representations of the movements required to write, from a lesion in, or connections to, the frontal premotor cortex that converts these spatial representations to motor programs (Exner's area).  A right-handed woman with Marchiafava Bignami disease and lesions of the genu and splenium of her corpus callosum had apraxic agraphia without ideomotor apraxia of her left. A disconnection of Exner's area in the left hemisphere from the right hemisphere's premotor and motor areas may have led to her inability to write with her left hand. Read More

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http://dx.doi.org/10.1080/13554794.2018.1444780DOI Listing
February 2018
5 Reads

Simultaneous acute Marchiafava-Bignami disease and central pontine myelinolysis: A case report of a challenging diagnosis.

Medicine (Baltimore) 2018 Feb;97(8):e9878

Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Rationale: Marchiafava-Bignami disease (MBD) is a rare disease characterized by demyelination of the corpus callosum. It is most commonly seen in patients with chronic alcoholism. The clinical diagnosis of MBD can be difficult due to its nonspecific manifestation. Read More

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http://dx.doi.org/10.1097/MD.0000000000009878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841975PMC
February 2018
8 Reads

Clinical and radiological features of Marchiafava-Bignami disease.

Medicine (Baltimore) 2018 Feb;97(5):e9626

Department of Neurology, Shengjing Hospital of China Medical University, Heping District, Shenyang, Liaoning, People's Republic of China.

Marchiafava-Bignami disease (MBD) is a rare neurological disease usually associated with chronic alcoholism and characterized by demyelination and necrosis. Our aims were to describe the clinicoradiological features and identify factors that may affect the prognosis of patients with MBD.We examined clinical manifestations, laboratory results, and neuroradiological features of 9 patients with MBD. Read More

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http://dx.doi.org/10.1097/MD.0000000000009626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805414PMC
February 2018
1 Read

Fatal serotonin syndrome in a patient with Marchiafava-Bignami disease: Combined neurological and psychiatric emergency.

Neurol Neurochir Pol 2018 Mar 31;52(2):277-280. Epub 2017 Oct 31.

King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

Marchiafava-Bignami disease (MBD) is a rare fatal neurological disorder characterized by demyelination, primary degeneration, and necrosis of the corpus callosum. Although MBD is mostly associated with chronic alcohol consumption and malnutrition, it has been reported in non-alcoholic patients. Serotonin syndrome is a rare but potentially fatal side effect of antidepressants that results from overstimulation of both central and peripheral serotonergic receptors. Read More

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http://dx.doi.org/10.1016/j.pjnns.2017.10.011DOI Listing
March 2018
19 Reads

Marchiafava Bignami disease.

Neurol India 2017 Nov-Dec;65(6):1440-1441

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.4103/0028-3886.217948DOI Listing
November 2017
4 Reads

Demyelinating diseases as a result of cerebral edema?

Med Hypotheses 2017 Jul 10;104:10-14. Epub 2017 May 10.

Helios-Klinikum Pirna, Struppener Straβe 13, D-01796 Pirna, Saxony, Germany. Electronic address:

Due to the elastic properties of the human organs, tissue edema causes an increased tissue pressure. This phenomenon leads to a reduction of blood circulation or ischemia, and thus leads to the hypothesis that tissue edema can be the cause of demyelinating lesions. Even though brain edema occurs in the whole brain, the authors assume that the characteristically focal appearance of demyelinated lesions, for instance of multiple sclerosis plaques, are attributable to anatomical and structural characteristics of the brain. Read More

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http://dx.doi.org/10.1016/j.mehy.2017.05.010DOI Listing
July 2017
9 Reads

Marchiafava-Bignami's Disease, as Etiologic Diagnosis of Athetosis.

Ann Neurosci 2017 May 21;24(1):57-60. Epub 2017 Apr 21.

Interna de Medicina, Universidad de los Andes de Chile, Santiago, Chile.

The Marchiafava-Bignami disease, characterized by demyelination and necrosis of the corpus callosum, has typically been associated with chronic alcohol intake, and clinically has various symptoms and signs. However, several cases have been reported without alcohol association, and these - according to several publications - have some common points, such as preference for female, related to malnutrition, and radiological involvement of the splenium of the corpus callosum. We report a case of a patient with the characteristics described above and whose clinical manifestation was Athetosis. Read More

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http://dx.doi.org/10.1159/000464424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448430PMC
May 2017
3 Reads

A rare case of Marchiafava-Bignami disease: Extracallosal lesions involving bilateral medipeduncle.

Neurol India 2017 May-Jun;65(3):642-643

Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

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http://dx.doi.org/10.4103/neuroindia.NI_365_16DOI Listing
May 2017
18 Reads

Marchiafava-Bignami Disease: A Rare Clinical Dilemma.

J Assoc Physicians India 2017 Mar;65(3):106-107

Professor & Unit Head, Department of Medicine, RNT Medical College, Udaipur, Rajasthan.

Marchiafava-Bignami Disease (MBD) is a progressive neurological disease, characterized by corpus callosal demyelination and necrosis and subsequent atrophy. It is usually seen in the context of alcoholism and malnutrition. Clinical diagnosis of this disease is quite challenging due to various presentations but a high degree of suspicion often leads to the correct diagnosis with help of neuroimaging. Read More

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March 2017
13 Reads

Clinical Reasoning: Corpus callosum lesion with multiple strokes.

Neurology 2017 04;88(14):e137-e142

From the Departments of Neurology (Z.S., N.A., B.R., M.H.) and Pathology (L.S.), Rutgers New Jersey Medical School, Newark, NJ.

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http://dx.doi.org/10.1212/WNL.0000000000003797DOI Listing

Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: how poor nutrition contributes to the alcoholic syndrome, as Marchiafava-Bignami disease.

Eur J Clin Nutr 2017 05 22;71(5):580-586. Epub 2017 Feb 22.

Programa de Pós-Graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brazil.

Ethanol is an important risk factor for the occurrence of several brain disorders that depend on the amount, period and frequency of its consumption. Chronic use of ethanol often leads to the development of neurodegenerative syndromes, which cause morphological and functional impairments such as foetal alcohol syndrome in newborns exposed to ethanol during pregnancy, Wernicke-Korsakoff Syndrome and, more rarely, Marchiafava-Bignami disease (MBD). MBD is characterized by primary degeneration of the corpus callosum, without inflammation and is associated with oxidative stress and hypovitaminosis, as well as altered mental status, to mention dementia, seizures, depression and so on. Read More

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http://dx.doi.org/10.1038/ejcn.2016.267DOI Listing
May 2017
9 Reads

Neuroimaging of chronic alcohol misuse.

J Med Imaging Radiat Oncol 2017 Aug 16;61(4):435-440. Epub 2016 Dec 16.

Neuroradiology and Neurointerventional Service, Department of Radiology, Beaumont Hospital, Beaumont, Ireland.

Alcohol is one of the most commonly abused substances worldwide. It results in a wide range of diseases and disorders affecting many organ systems. Alcohol-related nutritional deficiencies and electrolyte disturbance leave chronic abusers at risk of a range of demyelinating conditions to which the radiologist and clinician should always be alert. Read More

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http://dx.doi.org/10.1111/1754-9485.12572DOI Listing
August 2017
10 Reads
0.951 Impact Factor

Partial interhemispheric disconnection syndrome (P-IHDS) secondary to Marchiafava-Bignami disease type B (MBD-B).

BMJ Case Rep 2016 Nov 23;2016. Epub 2016 Nov 23.

James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, Norfolk, UK.

A 53-year-old man with a 35-year history of excessive alcohol intake presents to our neurology department with 4-year history of progressive neurocognitive deterioration and disconnection syndrome. MRI head demonstrates extensive demyelination of the corpus callosum (and of extracallosal sites as well), leading to a diagnosis of Marchiafava-Bignami disease. He was given treatment with vitamin B complex (including folate) and was assessed and managed by psychology, occupational therapy and physiotherapy with initial signs of improvement. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2016-21682
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http://dx.doi.org/10.1136/bcr-2016-216823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174772PMC
November 2016
11 Reads

Altered Sensorium in a Young Male: Marchiafava Bignami Disease Revisited.

J Assoc Physicians India 2016 11;64(11):86-88

Professor, Dept. of Medicine, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra.

Marchiafava Bignami disease (MBD) is a rare and devastating complication of chronic alcoholism. Degeneration of the corpus callosum is the hallmark feature of MBD. Early diagnosis of MBD by its typical "Sandwich Sign" on magnetic resonance imaging (MRI). Read More

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November 2016
11 Reads

The addicted brain: imaging neurological complications of recreational drug abuse.

Radiologia 2017 Jan - Feb;59(1):17-30. Epub 2016 Oct 20.

Área Clínica de Imagen Médica, Hospital Universitario y Politécnico La Fe, Valencia, España.

Recreational drug abuse represents a serious public health problem. Neuroimaging traditionally played a secondary role in this scenario, where it was limited to detecting acute vascular events. However, thanks to advances in knowledge about disease and in morphological and functional imaging techniques, radiologists have now become very important in the diagnosis of acute and chronic neurological complications of recreational drug abuse. Read More

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http://dx.doi.org/10.1016/j.rx.2016.09.005DOI Listing
April 2018
7 Reads

Marchiafava-Bignami and Alcohol Related Acute Polyneuropathy: The Cooccurrence of Two Rare Entities.

Case Rep Neurol Med 2016 7;2016:5848572. Epub 2016 Sep 7.

Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives. The aim of this article is to represent the first reported case with cooccurrence of two rare alcohol related complications. Case Report. Read More

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http://dx.doi.org/10.1155/2016/5848572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030413PMC
September 2016
14 Reads

Mutism Caused by Severe Demyelination in a Patient With Marchiafava-Bignami Disease.

J Emerg Med 2016 Dec 16;51(6):e129-e132. Epub 2016 Sep 16.

Yale New Haven Hospital, Yale School of Medicine, New Haven, Connecticut; David Geffen School of Medicine at UCLA, Los Angeles, California.

Background: Marchiafava-Bignami (MB) disease is a rare disorder that causes primary degeneration of the corpus callosum. It is associated with chronic alcohol consumption caused by either a toxic or nutritional etiology.

Case Report: We report a case of a 54-year-old woman who presented to our emergency department with complete mutism caused by MB disease that completely resolved with intravenous thiamine and dextrose therapy. Read More

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http://dx.doi.org/10.1016/j.jemermed.2016.07.007DOI Listing
December 2016
5 Reads

Marchiafava-Bignami disease in chronic alcoholic patient.

Radiol Case Rep 2016 Sep 9;11(3):234-7. Epub 2016 Jul 9.

Radiology Department, Medical College Baroda, SSG Hospital, Vadodara, Gujarat, India.

Marchiafava-Bignami disease is a rare toxic encephalopathy seen mostly in chronic alcoholics due to progressive demyelination and necrosis of the corpus callosum. It may involve adjacent white matter and subcortical regions. We present here the magnetic resonance imaging findings of Machiafava-Bignami disease in a chronic alcoholic patient. Read More

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http://dx.doi.org/10.1016/j.radcr.2016.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996925PMC
September 2016
5 Reads

Vegetarian diet and excessive tea consumption: a dangerous association?

Metab Brain Dis 2017 02 15;32(1):271-274. Epub 2016 Aug 15.

Unit of Neurology, Ospedale Bolognini, Seriate, BG, Italy.

Rare metabolic diseases may sometimes arise acutely and endanger human life if not immediately recognized and treated. Marchiafava Bignami disease is an uncommon neurologic disorder described in alcohol abusers and characterized by an acute severe damage of brain white matter. Even more rarely, it has been reported in non-alcohol addicted patients, but never in vegetarian people. Read More

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http://dx.doi.org/10.1007/s11011-016-9893-zDOI Listing
February 2017
7 Reads

[Marchiafava-Bignami disease (Case-report)].

Neuropsychopharmacol Hung 2016 06;18(2):115-8

MH EK Honvédkórház, Pszichiátriai osztály, Budapest, Hungary.

Marchiafava-Bignami disease (MBD) is caused by damage of the corpus callosum. There are acute, subacute and chronic forms, it occurs most frequently among alcoholic patients. A variety of neurological symptoms, epileptic seizures, and coma may be associated with the disease, but the chronic form may start with acute confusion and dementia, interhemispherial disconnection syndrome or with slow progressive changes in behavior. Read More

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June 2016
4 Reads

Marchiafava-Bignami Disease with frontal cortex involvement and late onset, long-lasting psychiatric symptoms: a case report.

Riv Psichiatr 2016 Mar-Apr;51(2):79-82

Institute of Psychiatry, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy - AOU Maggiore della Carità, Novara, Italy.

Aims: To describe the case and management of a patient with Marchiafava-Bignami Disease (MBD) with frontal cortical lesions, no specific symptom at first referral to the Emergency Room, and late onset of atypical psychiatric symptoms.

Methods: We report the case of a 44-year-old patient with a history of chronic alcohol abuse, eventually diagnosed with MBD.

Results: Magnetic Resonance showed lesions in the splenium and the body of corpus callosum and bilateral lesions of the frontal cortex. Read More

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http://www.rivistadipsichiatria.it/articoli.php?archivio=yes
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http://dx.doi.org/10.1708/2246.24202DOI Listing
August 2017
12 Reads

Marchiafava: Bignami Disease Treated with Parenteral Thiamine.

Indian J Psychol Med 2016 Mar-Apr;38(2):147-9

Department of Psychiatry, B. J. Medical College, Ahmedabad, Gujarat, India.

Marchiafava - Bignami disease is rare sequelae of chronic alcohol use. We present a case with transient ischemic attack like presentation and its management with parenteral thiamine. A 53 year old male with history of country liquor use since 32 years was brought to hospital with acute onset of delirium & mild weakness involving motor functions of left side of the body, non-reactive planters and exaggerated tendon reflexes on left side. Read More

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http://dx.doi.org/10.4103/0253-7176.178810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820555PMC
April 2016
4 Reads

[A case of Marchiafava-Bignami disease suggesting vasogenic edema].

Rinsho Shinkeigaku 2016 30;56(1):17-22. Epub 2015 Nov 30.

Department of Neurology, Saiseikai Otaru Hospital.

A 61-year-old alcoholic man was admitted to our hospital because of disturbance of consciousness. He also exhibited external ophthalmoplegia, diplopia and mild rigidity, but tendon reflex was normal. On brain MRI, diffusion weighted images (DWI) and apparent diffusion coefficient (ADC) map depicted high intensity in the splenium of the corpus callosum. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-000774DOI Listing
December 2016
4 Reads

Marchiafava-Bignami disease in an AIDS patient.

Arq Neuropsiquiatr 2016 Feb 20;74(2):180. Epub 2015 Oct 20.

Departamento de Neurologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

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http://dx.doi.org/10.1590/0004-282X20150173DOI Listing
February 2016
2 Reads

Marchiafava-Bignami disease with asymmetric extracallosal lesions.

Arch Med Sci 2015 Aug 11;11(4):895-8. Epub 2015 Aug 11.

Department of Neurology, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing, China.

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http://dx.doi.org/10.5114/aoms.2015.53312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548044PMC
August 2015
3 Reads

Chronic stage of Marchiafava-Bignami disease.

Arq Neuropsiquiatr 2015 Oct 11;73(10):890. Epub 2015 Aug 11.

Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, BR.

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http://dx.doi.org/10.1590/0004-282X20150103DOI Listing
October 2015
4 Reads

Neurological and psychiatric findings of marchiafava-bignami disease in a nonalcoholic diabetic patient with high blood glucose levels.

J Neuropsychiatry Clin Neurosci 2015 ;27(2):e149-50

Dept. of Neurology, Marmara University Hospital, Istanbul, Turkey.

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http://dx.doi.org/10.1176/appi.neuropsych.14030056DOI Listing
January 2016
7 Reads

Neurologic Manifestations of Chronic Liver Disease and Liver Cirrhosis.

Curr Probl Diagn Radiol 2015 Sep-Oct;44(5):449-61. Epub 2015 Mar 20.

Department of Radiology/Interventional Radiology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi, India. Electronic address:

The normal functioning of brain is intimately as well as intricately interrelated with normal functioning of the liver. Liver plays a critical role of not only providing vital nutrients to the brain but also of detoxifying the splanchnic blood. Compromised liver function leads to insufficient detoxification thus allowing neurotoxins (such as ammonia, manganese, and other chemicals) to enter the cerebral circulation. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2015.03.004DOI Listing
May 2016
9 Reads
1 Citation

[Investigating the symptoms of white matter disorders].

Authors:
Mitsuru Kawamura

Brain Nerve 2015 Apr;67(4):445-50

Department of Neurology, Showa University School of Medicine.

In this presentation, I will examine the intricate systemic connections in the white matter and the disturbances that occur due to diseases. In particular, I will discuss Marchiafava-Bignami disease, leukodystrophy with neuroaxonal spheroids, and myotonic dystrophy. Investigation of all three diseases reveals the crosstalk essential for the healthy brain and the resulting dysfunctions that follow lesions of different etiologies. Read More

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http://dx.doi.org/10.11477/mf.1416200161DOI Listing
April 2015
6 Reads

Marchiafava-Bignami disease as a cause of visual hallucinations.

Braz J Psychiatry 2015 Jan-Mar;37(1):82

Neuroradiology Department, Centro Hospitalar de S. João, Porto, Portugal.

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http://dx.doi.org/10.1590/1516-4446-2014-1529DOI Listing
September 2015
5 Reads

Marchiafava-Bignami disease with rare etiology: A case report.

Exp Ther Med 2015 Apr 5;9(4):1515-1517. Epub 2015 Feb 5.

The Second Department of Neurology, Harrison International Peace Hospital, Hengshui, Hebei 053000, P.R. China.

A male, 62-year-old patient was admitted to hospital due to dizziness and gait disturbance for 10 days. The patient had fallen a few times due to the gait instability, which was associated with stiffness and memory loss. The patient had undergone cardiac carcinoma surgery three years previously and had no drinking history. Read More

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http://dx.doi.org/10.3892/etm.2015.2263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353765PMC
April 2015
8 Reads

Teaching NeuroImages: Reversible widespread brain MRI lesions in Marchiafava-Bignami disease.

Neurology 2015 Mar;84(11):e81-2

From the Clinic of Neurology (I.D., J. Dačković, S.M., J. Drulović) and MRI Centre (I.N.), Clinical Centre of Serbia, Belgrade; University of Belgrade School of Medicine (I.D., S.M., J. Drulović), Serbia; and County Hospital (M.G.-K.) Užice, Serbia.

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http://dx.doi.org/10.1212/WNL.0000000000001373DOI Listing
March 2015
4 Reads

Marchiafava-Bignami disease triggered by poorly controlled diabetes mellitus.

Neurologia 2016 Sep 26;31(7):498-500. Epub 2015 Feb 26.

Servicio de Neurología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.

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http://dx.doi.org/10.1016/j.nrl.2015.01.001DOI Listing
September 2016
6 Reads

Marchiafava-Bignami disease in a trauma patient.

J Emerg Trauma Shock 2015 Jan-Mar;8(1):52-4

Department of Surgery, Lincoln Medical and Mental Health Center, Bronx, New York, USA.

Marchiafava-Bignami disease (MBD) is a rare pathological condition affecting the corpus callosum (CC), characterized by progressive demyelination and necrosis. While usually found in patients with chronic alcoholism, it has rarely been characterized in non-alcoholics. We describe a trauma patient with an unknown mechanism of injury, who was found to have MBD after remaining comatose for a prolonged period of time. Read More

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http://dx.doi.org/10.4103/0974-2700.150399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335160PMC
February 2015
6 Reads

[Relationship between callosal lesions and cerebral microhemorrhage in Marchiafava-Bignami disease].

Nihon Arukoru Yakubutsu Igakkai Zasshi 2014 Oct;49(5):238-48

Marchiafava-Bignami disease is a rare alcohol-associated disorder. Clinical features include not only disturbed consciousness, dysarthria, tetraparesis, and astasia-abasia as initial symptom but also cognitive deficits and symptoms of interhemispheric disconnection as clinical outcomes. The clinical significance of cerebral microhemorrhage has been recognized in patients with cognitive deficits. Read More

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October 2014
5 Reads

Spinal anesthesia in a patient with Marchiafava-Bignami disease.

Can J Anaesth 2015 May 30;62(5):556-7. Epub 2015 Jan 30.

The Department of Anesthesiology and Perioperative Care, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s12630-015-0330-2DOI Listing
May 2015
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Marchiafava-Bignami disease presenting as acute dysarthria and ataxia.

Alcohol Alcohol 2015 Mar 22;50(2):256-7. Epub 2014 Dec 22.

Department of Neurology, Mount Sinai Beth Israel, 10 Union Square East, New York, NY 10003, USA

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http://dx.doi.org/10.1093/alcalc/agu093DOI Listing
March 2015
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Histopathological and imaging modifications in chronic ethanolic encephalopathy.

Rom J Morphol Embryol 2014 ;55(3):797-801

Department of Anatomy and Embryology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania;

Chronic abuse of alcohol triggers different types of brain damage. The Wernicke-Korsakoff syndrome gets together Wernicke's encephalopathy and Korsakoff's syndrome. Another type of encephalopathy associated with chronic ethanol consumption is represented by the Marchiafava-Bignami malady or syndrome, an extremely rare neurological disorder, which is characterized by a demielinization of corpus callosum, extending as far as a necrosis. Read More

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http://www.rjme.ro/RJME/resources/files/550314797801.pdf
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August 2015
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Structural and microstructral imaging of the brain in alcohol use disorders.

Authors:
Natalie M Zahr

Handb Clin Neurol 2014 ;125:275-90

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; Neuroscience Program, SRI International, Menlo Park, CA, USA. Electronic address:

Magnetic resonance imaging (MRI), by enabling rigorous in vivo study of the longitudinal, dynamic course of alcoholism through periods of drinking, sobriety, and relapse, has enabled characterization of the effects of chronic alcoholism on the brain in the human condition. Importantly, MRI has distinguished alcohol-related brain effects that are permanent versus those that are reversible with abstinence. In support of postmortem neuropathologic studies showing degeneration of white matter, MRI has shown a specific vulnerability of brain white matter to chronic alcohol exposure by demonstrating white-matter volume deficits, yet not leaving selective gray-matter structures unscathed. Read More

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http://dx.doi.org/10.1016/B978-0-444-62619-6.00017-3DOI Listing
July 2016
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Molecular and neurologic responses to chronic alcohol use.

Handb Clin Neurol 2014 ;125:157-71

Virginia Commonwealth University Alcohol Research Center, Department of Pharmacology and Toxicology, Center for Study of Biological Complexity and Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

This chapter provides an overview of current knowledge on the molecular and clinical aspects of chronic alcohol effects on the central nervous system. This drug is almost ubiquitous, widely enjoyed socially, but produces a diverse spectrum of neurologic disease when abused. Acutely, alcohol interacts predominantly with γ-aminobutyric acid-A (GABA-A) and N-methyl-d-aspartate (NMDA) receptors, but triggers diverse signaling events within well-defined neural pathways. Read More

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http://dx.doi.org/10.1016/B978-0-444-62619-6.00010-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412740PMC
July 2016
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