296 results match your criteria Marchiafava-Bignami Disease

Amantadine as a Potential Treatment for Marchiafava-Bignami Disease: Case Reports and a Possible Mechanism.

Case Rep Neurol Med 2022 11;2022:4585206. Epub 2022 Apr 11.

Department of Neurology, Vanderbilt University Medical Center, 1301 Medical Center Drive, Nashville, TN, USA.

Introduction: Several reports have described the use of amantadine for managing symptoms in Marchiafava-Bignami disease (MBD); however, amantadine's role for the treatment of MBD symptoms is unclear. Here, we describe 2 patients with MBD who were treated with amantadine and hypothesize a potential mechanism responsible for clinical benefit. . Read More

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Marchiafava-Bignami disease presenting as reversible coma.

BMJ Case Rep 2022 Apr 4;15(4). Epub 2022 Apr 4.

Neurology, UF Health Jacksonville, Jacksonville, Florida, USA.

Marchiafava-Bignami disease (MBD) is a rare demyelinating condition of the corpus callosum and subcortical white matter that is most commonly seen in alcoholic patients. The course of the disease varies with symptoms that range from dementia to complete coma; severe intermittent sympathetic storming with abnormal posturing is often reported in literature. It is presumably secondary to a deficiency of B complex vitamins, specifically thiamine and many patients have clinical improvement after repletion of B vitamins. Read More

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Marchiafava-Bignami disease concurrent with intracerebral hemorrhage: a case description.

Quant Imaging Med Surg 2022 Apr;12(4):2596-2601

Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

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Classical Imaging Finding in Marchiafava Bignami Disease.

Neurol India 2021 Nov-Dec;69(6):1627-1628

Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

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January 2022

Neuropsychological Tests for Patients with Marchiafava-Bignami Disease: A Case Report.

Psychiatry Investig 2020 Dec 23;17(12):1244-1246. Epub 2020 Dec 23.

Department of Psychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.

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December 2020

A rare MRI finding in a patient with Marchiafava-Bignami disease.

Ting Xu Kundian Guo

Neurol Sci 2021 Dec 22;42(12):5419-5420. Epub 2021 Oct 22.

Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, 610041, Sichuan, China.

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December 2021

Marchiafava-Bignami disease in a patient with schizophrenia and alcohol use disorder.

Actas Esp Psiquiatr 2021 Sep 1;49(5):228-231. Epub 2021 Sep 1.

Universitario y Politécnico La Fe, Valencia, España Universidad de Valencia, Valencia, España.

Substance-related disorders are the most frequent comorbidity in schizophrenia. Concretely, alcohol is the most commonly consumed substance after tobacco. Patients with schizophrenia with this comorbidity have a worse clinical course and can develop serious neuropsychiatric complications. Read More

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September 2021

Disconnected Motor Intention and Spatial Attention in a Case of Probable Marchiafava-Bignami Disease.

Cogn Behav Neurol 2021 09 2;34(3):226-232. Epub 2021 Sep 2.

Department of Human Neurophysiology, Fukushima Medical University, Fukushima, Japan.

Marchiafava-Bignami disease (MBD) is a rare complication of chronic alcoholism that typically causes demyelination and necrosis of the corpus callosum. Here, we report a man with probable MBD with callosal and right medial paracentral lesions who presented with abnormal reaching behavior and ideomotor apraxia of the left hand. He exhibited difficulty in reaching with the left hand when a target object was placed on his right-hand side, and he exhibited rightward bias when using his right hand in a line bisection task. Read More

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September 2021

Marchiafava-Bignami Disease: A Case of Success.

Prim Care Companion CNS Disord 2021 08 26;23(5). Epub 2021 Aug 26.

Department of Neurosciences and Mental Health, Psychiatry Department, Santa Maria Hospital, Lisbon, Portugal.

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[Mild Encephalopathy with Reversible Splenial Lesion(MERS)].

Aki Sato

No Shinkei Geka 2021 Mar;49(2):413-417

Department of Neurology, Niigata City General Hospital.

Mild encephalitis/encephalopathy with a reversible splenial lesion(MERS)is a clinically and radiologically benign condition that has been described within the past two decades. MRI findings include isolated symmetrical ovoid lesions of the splenium with a high-intensity signal on DWI and decreased apparent diffusion coefficient. These findings have been associated with viral infections, epilepsy, antiepileptic drug usage, and metabolic disturbances, among others. Read More

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Rare case of Marchiafava-Bignami disease due to thiamine deficiency and malnutrition.

BMJ Case Rep 2020 Dec 10;13(12). Epub 2020 Dec 10.

Family Medicine, The University of Alabama System, Tuscaloosa, Alabama, USA.

Marchiafava-Bignami disease (MBD) is a rare, toxic demyelinating disorder of the central nervous system associated with chronic alcoholism and malnutrition. The clinical presentation is varied and non-specific, including symptoms of acute dementia, impaired consciousness, dysarthria, hemiparesis, pyramidal tract signs, seizure activity, ataxia and signs of interhemispheric disconnection. The differential diagnosis of MBD may include Wernicke's encephalopathy, multiple sclerosis, encephalitis, infectious or paraneoplastic leucoencephalopathy, infarction, Alzheimer's disease, multi-infarct dementia and frontotemporal lobar degeneration (Pick) disease. Read More

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December 2020

Marchiafava-Bignami Disease Associated with Spinal Involvement.

Case Rep Neurol Med 2020 28;2020:8867383. Epub 2020 Oct 28.

Department of Neurology, Sanatorio Güemes-University Hospital, Buenos Aires, Argentina.

Marchiafava-Bignami disease (MBD) is a rare disorder of unknown etiology, strongly associated with alcoholism and malnutrition. MBD causes primary involvement of the corpus callosum, leading to confusion, dysarthria, seizures, and frequent death. We report the case of a 54-year-old male without a history of alcoholism or known malabsorption disease, who presented with altered consciousness and neurologic impairment. Read More

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October 2020

Marchiafava-Bignami disease-like corpus callosum lesions due to moyamoya disease.

Neurol Sci 2021 03 7;42(3):1161-1164. Epub 2020 Sep 7.

Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Kišpatićeva 12, 10000, Zagreb, Croatia.

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Depression preceding Marchiafava-Bignami disease.

Aust N Z J Psychiatry 2021 02 28;55(2):224-225. Epub 2020 Jul 28.

Department of Psychiatry & Mental Health, Tunku Abdul Rahman Institute of Neuroscience, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.

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February 2021

Diverse MRI findings and clinical outcomes of acute Marchiafava-Bignami disease.

Acta Radiol 2021 Jul 27;62(7):904-908. Epub 2020 Jul 27.

Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.

Background: The acute onset of Marchiafava-Bignami disease (MBD) is difficult to capture, and its clinical manifestations are overlapped. Magnetic resonance imaging (MRI) is very useful in the diagnosis of acute MBD.

Purpose: To investigate the MRI features and clinical outcomes of acute MBD. Read More

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Simultaneous acute Marchiafava-Bignami disease and posterior reversible encephalopathy syndrome: a case almost misdiagnosed.

Quant Imaging Med Surg 2020 Jun;10(6):1392-1395

Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.

Marchiafava-Bignami disease (MBD) is a rare neurological disease, and is characterized by callosal lesions consisting of necrosis and demyelination. Posterior reversible encephalopathy syndrome (PRES) is a clinical syndrome, and refers to a disorder with reversible subcortical vasogenic brain edema, predominantly involving the bilateral parieto-occipital regions. Never before had articles reported that the two diseases occurred simultaneously. Read More

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Reversible lesion in the splenium of the corpus callosum in a patient with chronic alcoholism.

J Gen Fam Med 2020 May 18;21(3):84-86. Epub 2020 Apr 18.

Department of Neurology International University of Health and Welfare Hospital Nasushiobara Japan.

Marchiafava-Bignami disease (MBD) is often diagnosed in chronic alcoholics. The disease processes typically involve the corpus callosum and clinically presents with various manifestations on the basis of clinical condition, extent of the splenium of the corpus callosum involvement at brain magnetic resonance imaging (MRI), and prognosis. We report a patient affected by MBD, who presented an isolated reversible splenial lesion at brain MRI and achieved a favorable recovery. Read More

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Marchiafava-Bignami Disease: Two Chronologically Distinct Stages in the Same Patient.

Can J Neurol Sci 2020 09 30;47(5):689-690. Epub 2020 Apr 30.

Neuroradiology Department, Hospital de Braga, Braga, Portugal.

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September 2020

Comprehensive neuropsychological findings in a case of Marchiafava-Bignami disease.

Clin Neuropsychol 2021 08 26;35(6):1191-1202. Epub 2020 Feb 26.

Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL, USA.

Objective: Marchiafava-Bignami disease (MBD) is a rare complication associated with chronic heavy alcohol use, with case reports documenting a range of cognitive outcomes. Given the variability in MBD presentation and outcomes, milder cases may remain undiagnosed and few studies or case reports have presented a comprehensive neuropsychological profile of these patients. The objective of this case study was to describe the neuropsychological presentation and findings of a case of likely MBD. Read More

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Marchiafava-Bignami disease: Report of three cases.

Ideggyogy Sz 2020 Jan;73(1-2):65-69

Bakırkoy Prof. Dr. Mazhar Osman Mental and Neurological Diseases Training and Research Hospital, Istanbul, Turkey.

Marchiafava-Bignami disease (MBD) is a rare alcohol-associated disorder characterized by demyelination and necrosis of the corpus callosum. We report three patients who had history of chronic alcoholism, different clinical presentation and MRI findings consistent with the diagnosis of Marchiafava-Bignami disease. Read More

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January 2020

Marchiafava Bignami Disease - A Case Report.

J Assoc Physicians India 2020 Jan;68(1):61

SRM Medical College Hospital and Research Institute.

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January 2020

Neuroimaging of Multiple Sclerosis Mimics.

Neurol Clin 2020 02 24;38(1):149-170. Epub 2019 Oct 24.

Dent Neurological Institute, Buffalo, NY, USA.

Multiple sclerosis (MS) is the most common immune-mediated disease of the central nervous system, characterized by demyelinating lesions of the brain and the spinal cord. Although it is extremely important to diagnose this condition in a timely manner, to initiate and monitor treatment to prevent permanent neurologic damage and disability, it is also necessary that other demyelinating conditions collectively referred to as MS mimics be identified and excluded. This article describes the in-depth neuroimaging characteristics and morphology of the pathologic lesions on the various neuroimaging modalities. Read More

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February 2020

Marchiafava-Bignami Disease in a Patient with No Alcohol Abuse.

Neurol India 2019 Jul-Aug;67(4):1169

Department of Emergency Medicine, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.

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October 2020

Marchiafava-Bignami disease with haemophagocytic lymphohistiocytosis as a postoperative complication of cardiac surgery.

BMJ Case Rep 2019 Aug 26;12(8). Epub 2019 Aug 26.

Neurological Science, Tohoku University School of Medicine, Sendai, Miyagi, Japan.

Marchiafava-Bignami disease (MBD) is a rare complication of chronic alcoholism; however, MBD in a non-alcoholic diabetic patient has rarely been reported. The aetiology or pathophysiology of MBD is still unknown. A 50-year-old man with a history of untreated diabetes mellitus underwent on-pump beating coronary artery bypass graft surgery (CABG) surgery for three-vessel and left main coronary disease. Read More

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Intermittent alien hand syndrome caused by Marchiafava-Bignami disease: A case report.

Medicine (Baltimore) 2019 Aug;98(34):e16891

Department of Neurology, The First Hospital of Jilin University, Changchun.

Rationale: Alien Hand syndrome (AHS) is characterized in most patients by seemingly purposeful, involuntary movements of the extremities. It is not well known among physicians on account of its diverse clinical manifestations.

Patient Concerns: We present a 57-year-old Chinese man who could not stop or turn himself around as he involuntarily and uncontrollably walked forward, which had happened frequently in the month prior to treatment. Read More

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"CHOICES": An acronym to aid in delineating potential causes of non-metabolic, non-infectious acute toxic leukoencephalopathy.

Eur J Radiol Open 2019 28;6:243-257. Epub 2019 Jun 28.

Department of Radiology, Division of Neuroradiology, University of Minnesota Medical Center, Minneapolis, MN, USA.

Purpose: To describe non-metabolic, non-infectious etiologies of acute toxic leukoencephalopathy (ATL) on DWI MRI, and provide a useful acronym to remember them.

Material And Methods: Our PACS archive was reviewed, yielding 185 patients with suspected ATL per MRI reports and clinical follow up; infectious or metabolic causes were excluded.

Result/discussion: The 87 included non-infectious, non-metabolic ATL patients' etiologies are represented by the acronym 'CHOICES': chemotherapy ('C',n = 34); heroin-induced ('H',n = 6), opioid analogues ('O',n = 14); immunosuppressant ('I',n = 11) or imidazole (n = 2); cocaine ('C',n = 1); environmental or ethanol abuse ('E',n = 5), splenial lesions ('S',n = 9), and 'other' (n = 5). Read More

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Clinical and neuroradiological features of 15 patients diagnosed with Marchiafava-Bignami disease.

Chin Med J (Engl) 2019 Aug;132(15):1887-1889

Department of Neurology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.

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