277 results match your criteria Marchiafava-Bignami Disease


Simultaneous acute Marchiafava-Bignami disease and posterior reversible encephalopathy syndrome: a case almost misdiagnosed.

Quant Imaging Med Surg 2020 Jun;10(6):1392-1395

Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.

Marchiafava-Bignami disease (MBD) is a rare neurological disease, and is characterized by callosal lesions consisting of necrosis and demyelination. Posterior reversible encephalopathy syndrome (PRES) is a clinical syndrome, and refers to a disorder with reversible subcortical vasogenic brain edema, predominantly involving the bilateral parieto-occipital regions. Never before had articles reported that the two diseases occurred simultaneously. Read More

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http://dx.doi.org/10.21037/qims-19-967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276366PMC

Reversible lesion in the splenium of the corpus callosum in a patient with chronic alcoholism.

J Gen Fam Med 2020 May 18;21(3):84-86. Epub 2020 Apr 18.

Department of Neurology International University of Health and Welfare Hospital Nasushiobara Japan.

Marchiafava-Bignami disease (MBD) is often diagnosed in chronic alcoholics. The disease processes typically involve the corpus callosum and clinically presents with various manifestations on the basis of clinical condition, extent of the splenium of the corpus callosum involvement at brain magnetic resonance imaging (MRI), and prognosis. We report a patient affected by MBD, who presented an isolated reversible splenial lesion at brain MRI and achieved a favorable recovery. Read More

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http://dx.doi.org/10.1002/jgf2.308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260156PMC

Marchiafava-Bignami Disease: Two Chronologically Distinct Stages in the Same Patient.

Can J Neurol Sci 2020 Apr 30:1-2. Epub 2020 Apr 30.

Neuroradiology Department, Hospital de Braga, Braga, Portugal.

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http://dx.doi.org/10.1017/cjn.2020.86DOI Listing

Comprehensive neuropsychological findings in a case of Marchiafava-Bignami disease.

Clin Neuropsychol 2020 Feb 26:1-12. Epub 2020 Feb 26.

Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL, USA.

Marchiafava-Bignami disease (MBD) is a rare complication associated with chronic heavy alcohol use, with case reports documenting a range of cognitive outcomes. Given the variability in MBD presentation and outcomes, milder cases may remain undiagnosed and few studies or case reports have presented a comprehensive neuropsychological profile of these patients. The objective of this case study was to describe the neuropsychological presentation and findings of a case of likely MBD. Read More

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http://dx.doi.org/10.1080/13854046.2020.1731608DOI Listing
February 2020

Marchiafava-Bignami disease: Report of three cases.

Ideggyogy Sz 2020 Jan;73(1-2):65-69

Bakırkoy Prof. Dr. Mazhar Osman Mental and Neurological Diseases Training and Research Hospital, Istanbul, Turkey.

Marchiafava-Bignami disease (MBD) is a rare alcohol-associated disorder characterized by demyelination and necrosis of the corpus callosum. We report three patients who had history of chronic alcoholism, different clinical presentation and MRI findings consistent with the diagnosis of Marchiafava-Bignami disease. Read More

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http://dx.doi.org/10.18071/isz.73.0065DOI Listing
January 2020

Marchiafava Bignami Disease - A Case Report.

J Assoc Physicians India 2020 Jan;68(1):61

SRM Medical College Hospital and Research Institute.

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January 2020

Neuroimaging of Multiple Sclerosis Mimics.

Neurol Clin 2020 02 24;38(1):149-170. Epub 2019 Oct 24.

Dent Neurological Institute, Buffalo, NY, USA.

Multiple sclerosis (MS) is the most common immune-mediated disease of the central nervous system, characterized by demyelinating lesions of the brain and the spinal cord. Although it is extremely important to diagnose this condition in a timely manner, to initiate and monitor treatment to prevent permanent neurologic damage and disability, it is also necessary that other demyelinating conditions collectively referred to as MS mimics be identified and excluded. This article describes the in-depth neuroimaging characteristics and morphology of the pathologic lesions on the various neuroimaging modalities. Read More

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http://dx.doi.org/10.1016/j.ncl.2019.09.002DOI Listing
February 2020
5 Reads

Marchiafava-Bignami Disease in a Patient with No Alcohol Abuse.

Neurol India 2019 Jul-Aug;67(4):1169

Department of Emergency Medicine, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.

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http://dx.doi.org/10.4103/0028-3886.266247DOI Listing
September 2019

Marchiafava-Bignami disease with haemophagocytic lymphohistiocytosis as a postoperative complication of cardiac surgery.

BMJ Case Rep 2019 Aug 26;12(8). Epub 2019 Aug 26.

Neurological Science, Tohoku University School of Medicine, Sendai, Miyagi, Japan.

Marchiafava-Bignami disease (MBD) is a rare complication of chronic alcoholism; however, MBD in a non-alcoholic diabetic patient has rarely been reported. The aetiology or pathophysiology of MBD is still unknown. A 50-year-old man with a history of untreated diabetes mellitus underwent on-pump beating coronary artery bypass graft surgery (CABG) surgery for three-vessel and left main coronary disease. Read More

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http://dx.doi.org/10.1136/bcr-2019-230368DOI Listing
August 2019
2 Reads

Intermittent alien hand syndrome caused by Marchiafava-Bignami disease: A case report.

Medicine (Baltimore) 2019 Aug;98(34):e16891

Department of Neurology, The First Hospital of Jilin University, Changchun.

Rationale: Alien Hand syndrome (AHS) is characterized in most patients by seemingly purposeful, involuntary movements of the extremities. It is not well known among physicians on account of its diverse clinical manifestations.

Patient Concerns: We present a 57-year-old Chinese man who could not stop or turn himself around as he involuntarily and uncontrollably walked forward, which had happened frequently in the month prior to treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000016891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716696PMC
August 2019
2 Reads

"CHOICES": An acronym to aid in delineating potential causes of non-metabolic, non-infectious acute toxic leukoencephalopathy.

Eur J Radiol Open 2019 28;6:243-257. Epub 2019 Jun 28.

Department of Radiology, Division of Neuroradiology, University of Minnesota Medical Center, Minneapolis, MN, USA.

Purpose: To describe non-metabolic, non-infectious etiologies of acute toxic leukoencephalopathy (ATL) on DWI MRI, and provide a useful acronym to remember them.

Material And Methods: Our PACS archive was reviewed, yielding 185 patients with suspected ATL per MRI reports and clinical follow up; infectious or metabolic causes were excluded.

Result/discussion: The 87 included non-infectious, non-metabolic ATL patients' etiologies are represented by the acronym 'CHOICES': chemotherapy ('C',n = 34); heroin-induced ('H',n = 6), opioid analogues ('O',n = 14); immunosuppressant ('I',n = 11) or imidazole (n = 2); cocaine ('C',n = 1); environmental or ethanol abuse ('E',n = 5), splenial lesions ('S',n = 9), and 'other' (n = 5). Read More

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http://dx.doi.org/10.1016/j.ejro.2019.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607360PMC
June 2019
7 Reads

Clinical and neuroradiological features of 15 patients diagnosed with Marchiafava-Bignami disease.

Chin Med J (Engl) 2019 Aug;132(15):1887-1889

Department of Neurology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.

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http://dx.doi.org/10.1097/CM9.0000000000000334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759113PMC
August 2019
2 Reads

Antemortem histopathology and imaging findings in a case of Marchiafava-Bignami disease.

J Clin Neurosci 2019 Aug 6;66:273-275. Epub 2019 Jun 6.

Department of Neurosurgery, Westmead Hospital, University of Sydney, Australia.

Marchiafava-Bignami disease (MBD) is a rare condition often associated with chronic alcohol abuse. Clinical presentation is diverse. Characteristic magnetic resonance imaging (MRI) changes in the corpus callosum are the mainstay of radiological diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183156
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http://dx.doi.org/10.1016/j.jocn.2019.05.009DOI Listing
August 2019
17 Reads

White-matter commissures: a clinically focused anatomical review.

Surg Radiol Anat 2019 Jun 22;41(6):613-624. Epub 2019 May 22.

Anatomy Department, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.

Purpose: The objective of this review is to provide a structured approach to the main white matter commissures, their anatomic and radiological definition and disease implications.

Methods: The Pubmed database and The JAMA Network were used for the literature review and the following terms were searched using Sort by: Best Match and Sort by: Most Recent: telencephalic commissure, forebrain commissure anatomy, fornix anatomy, commissure of fornix, posterior commissure, corpus callosum, commissural agenesis, Probst bundle, corpus callosum disorders review, corpus callosum diseases review, Marchiafava-Bignami, Alzheimer's disease and Forel commissure; 36 papers were selected, one excluded due to the language barrier.

Results: The interhemispheric communication in the brain is achieved via the brain commissures, bundles of white matter linking the two cerebral hemispheres. Read More

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http://link.springer.com/10.1007/s00276-019-02218-7
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http://dx.doi.org/10.1007/s00276-019-02218-7DOI Listing
June 2019
30 Reads

Overreligious beliefs with neuropsychiatric manifestations in a young lady-Rule out Marchiafava-Bignami disease.

Med J Armed Forces India 2019 Apr 15;75(2):228-231. Epub 2019 Apr 15.

Medical Officer, INS Circars, Vizag, India.

Marchiafava- Bignami disease is a rare condition characterized by demyelination of corpus callosum due to alcohol or malnutrition. Here we report a young lady who, due to her religious beliefs had stopped taking food and presented with neuropsychiatric manifestations. Neuroimaging was suggestive of Marchiafava Bignami disease and with adequate nutritional and thiamine therapy she had dramatic improvement clinically and had near complete resolution of lesions in neuroimaging. Read More

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http://dx.doi.org/10.1016/j.mjafi.2019.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495468PMC
April 2019
11 Reads

Reversible MR Findings in Marchiafava-Bignami Disease.

Case Rep Neurol Med 2019 6;2019:1951030. Epub 2019 Feb 6.

Neuroimaging and Neurointervention Unit, NHS and University Hospital "Saint Mary alle Scotte", Siena, Italy.

Marchiafava-Bignami Disease (MBD) is a toxic demyelinating disease often diagnosed in chronic alcoholics. The disease process typically involves the corpus callosum and clinically presents with various manifestations resulting in MBD type A and type B on the basis of clinical condition, extent of callosal involvement and extracallosal involvement at brain magnetic resonance imaging (MRI), and prognosis. The death rate is high. Read More

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http://dx.doi.org/10.1155/2019/1951030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381571PMC
February 2019
8 Reads

Refractory Nonconvulsive Status Epilepticus with Favorable Outcome in a Patient with Marchiafava-Bignami Disease.

J Clin Neurol 2019 Jul 11;15(3):393-394. Epub 2019 Mar 11.

Department of Neurology, Seoul National University Hospital, Seoul, Korea.

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http://dx.doi.org/10.3988/jcn.2019.15.3.393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620463PMC
July 2019
8 Reads

Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava-Bignami Disease: A Case Report and Literature Review.

Front Hum Neurosci 2019 27;13:79. Epub 2019 Feb 27.

Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China.

Marchiafava-Bignami disease (MBD) is a rare condition characterized by demyelination, necrosis and atrophy of the corpus callosum (CC), and mainly associated with alcoholism. MBD may present with various clinical manifestations. Brain magnetic resonance imaging (MRI) scan is important in prompt diagnosis and treatment of MBD. Read More

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http://dx.doi.org/10.3389/fnhum.2019.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401522PMC
February 2019
30 Reads
2.895 Impact Factor

MR imaging in the diagnosis of Marchiafava-Bignami syndrome.

Neurol India 2019 Jan-Feb;67(1):321-323

Department of Radiology and Imaging, Holy Family Hospital and Medical Research Centre, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.4103/0028-3886.253648DOI Listing
January 2020

Left hemispatial neglect with a splenial lesion.

Neurocase 2018 08 28;24(4):220-226. Epub 2018 Oct 28.

d Neurology Service and GRECC , Malcom Randall Veterans Affairs Medical Center , Gainesville , FL , USA.

With injury of the anterior two-thirds of the corpus callosum, each hemisphere's attentional bias to contralateral hemispace becomes manifest with each hand deviating ipsilaterally during line bisection tasks. Patients with infarctions in the right posterior cerebral artery distribution with occipital and splenial damage can also exhibit spatial neglect. The goal of this report is to learn the role of the splenium of the corpus callosum in mediating visuospatial attention. Read More

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https://www.tandfonline.com/doi/full/10.1080/13554794.2018.1
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http://dx.doi.org/10.1080/13554794.2018.1539501DOI Listing
August 2018
57 Reads

Bilateral middle cerebellar peduncles involvement a malnourished man with Marchiafava-Bignami disease.

Neurol Sci 2019 Feb 18;40(2):433-435. Epub 2018 Oct 18.

Department of Neurology, The Affiliated Hospital of Jiujiang University, No.57 Xunyang East Rode, Xunyang District, Jiujiang, 332000, Jiangxi Province, People's Republic of China.

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http://link.springer.com/10.1007/s10072-018-3608-7
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http://dx.doi.org/10.1007/s10072-018-3608-7DOI Listing
February 2019
33 Reads

A Case of Nonalcoholic Marchiafava-Bignami Disease with Left-Right Differential Agraphia of Chinese Characters.

Case Rep Neurol 2018 May-Aug;10(2):232-241. Epub 2018 Aug 29.

Department of Rehabilitation Medicine, Fukui General Hospital, Fukui City, Japan.

We report a 68-year-old right-handed female who was admitted to our hospital complaining chiefly of incontinence and decreased activity. Her brain images showed characteristics of Marchiafava-Bignami disease, such as symmetrical abnormal signals localized in the corpus callosum. The patient had no drinking habits. Read More

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https://www.karger.com/Article/FullText/492528
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http://dx.doi.org/10.1159/000492528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167702PMC
August 2018
7 Reads

Marchiafava-Bignami Disease Presenting as Acute Psychosis.

Indian J Psychol Med 2018 Sep-Oct;40(5):494-496

Department of Psychiatry, Jamaica Hospital Center, Jamaica, New York, USA.

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_56_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149298PMC
October 2018
9 Reads

Rapidly Resolving Nonalcoholic Marchiafava-Bignami Disease in the Setting of Malnourishment After Gastric Bypass Surgery.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618784318. Epub 2018 Jun 28.

Augusta University, Augusta, GA, USA.

We describe a rare case of nonalcoholic Marchiafava-Bignami disease (MBD) in the setting of malnourishment after gastric bypass. A 44-year-old nonalcoholic Caucasian woman with malnutrition after gastric bypass presented with 2 weeks of weakness. The patient acutely became stuporous. Read More

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http://dx.doi.org/10.1177/2324709618784318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062771PMC
June 2018
7 Reads

Reversible "ears of the lynx" sign in Marchiafava-Bignami disease.

Acta Neurol Belg 2019 Jun 16;119(2):275-277. Epub 2018 Jul 16.

Department of Neurology, Nîmes University Hospital, 4, Rue du Pr Debré, 30029, Nîmes Cedex 4, France.

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http://dx.doi.org/10.1007/s13760-018-0989-6DOI Listing
June 2019
7 Reads

Marchiafava-Bignami Disease with Cortical Involvement.

Clin Lab 2018 Jun;64(6):1055-1059

Background: Marchiafava-Bignami disease (MBD) is a neurological degenerative disorder with a pathognomonic hallmark of symmetric demyelination in the corpus callosum (CC). Most reported cases were chronic alcoholics and some showed cortical lesions related to poor clinical prognosis. Herein we report a case of a chronic alcoholic who presented with confusion and generalized weakness. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.171220DOI Listing
June 2018
10 Reads

Marchiafava-Bignami disease.

Authors:
H Matsuura K Shindo

QJM 2018 Oct;111(10):755

Department of Neurology, Kurashiki Central Hospital, 1-1-1, Miwa, Kurashiki-city, Okayama, Japan.

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http://dx.doi.org/10.1093/qjmed/hcy101DOI Listing
October 2018
5 Reads

Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease.

Neurocase 2018 02 26;24(1):59-67. Epub 2018 Feb 26.

c Neurology Service and GRECC , Malcom Randall Veterans Affairs Medical Center , Gainesville , FL , USA.

Apraxic agraphia can be caused by left hemispheric cerebral lesions in the area that contains the spatial representations of the movements required to write, from a lesion in, or connections to, the frontal premotor cortex that converts these spatial representations to motor programs (Exner's area).  A right-handed woman with Marchiafava Bignami disease and lesions of the genu and splenium of her corpus callosum had apraxic agraphia without ideomotor apraxia of her left. A disconnection of Exner's area in the left hemisphere from the right hemisphere's premotor and motor areas may have led to her inability to write with her left hand. Read More

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http://dx.doi.org/10.1080/13554794.2018.1444780DOI Listing
February 2018
14 Reads

Simultaneous acute Marchiafava-Bignami disease and central pontine myelinolysis: A case report of a challenging diagnosis.

Medicine (Baltimore) 2018 Feb;97(8):e9878

Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Rationale: Marchiafava-Bignami disease (MBD) is a rare disease characterized by demyelination of the corpus callosum. It is most commonly seen in patients with chronic alcoholism. The clinical diagnosis of MBD can be difficult due to its nonspecific manifestation. Read More

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http://dx.doi.org/10.1097/MD.0000000000009878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841975PMC
February 2018
22 Reads

Clinical and radiological features of Marchiafava-Bignami disease.

Medicine (Baltimore) 2018 Feb;97(5):e9626

Department of Neurology, Shengjing Hospital of China Medical University, Heping District, Shenyang, Liaoning, People's Republic of China.

Marchiafava-Bignami disease (MBD) is a rare neurological disease usually associated with chronic alcoholism and characterized by demyelination and necrosis. Our aims were to describe the clinicoradiological features and identify factors that may affect the prognosis of patients with MBD.We examined clinical manifestations, laboratory results, and neuroradiological features of 9 patients with MBD. Read More

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http://dx.doi.org/10.1097/MD.0000000000009626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805414PMC
February 2018
7 Reads

Fatal serotonin syndrome in a patient with Marchiafava-Bignami disease: Combined neurological and psychiatric emergency.

Neurol Neurochir Pol 2018 Mar 31;52(2):277-280. Epub 2017 Oct 31.

King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

Marchiafava-Bignami disease (MBD) is a rare fatal neurological disorder characterized by demyelination, primary degeneration, and necrosis of the corpus callosum. Although MBD is mostly associated with chronic alcohol consumption and malnutrition, it has been reported in non-alcoholic patients. Serotonin syndrome is a rare but potentially fatal side effect of antidepressants that results from overstimulation of both central and peripheral serotonergic receptors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283843173033
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http://dx.doi.org/10.1016/j.pjnns.2017.10.011DOI Listing
March 2018
27 Reads

Marchiafava Bignami disease.

Neurol India 2017 Nov-Dec;65(6):1440-1441

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.4103/0028-3886.217948DOI Listing
June 2019
11 Reads
1.084 Impact Factor

Demyelinating diseases as a result of cerebral edema?

Med Hypotheses 2017 Jul 10;104:10-14. Epub 2017 May 10.

Helios-Klinikum Pirna, Struppener Straβe 13, D-01796 Pirna, Saxony, Germany. Electronic address:

Due to the elastic properties of the human organs, tissue edema causes an increased tissue pressure. This phenomenon leads to a reduction of blood circulation or ischemia, and thus leads to the hypothesis that tissue edema can be the cause of demyelinating lesions. Even though brain edema occurs in the whole brain, the authors assume that the characteristically focal appearance of demyelinated lesions, for instance of multiple sclerosis plaques, are attributable to anatomical and structural characteristics of the brain. Read More

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http://dx.doi.org/10.1016/j.mehy.2017.05.010DOI Listing
July 2017
21 Reads

Marchiafava-Bignami's Disease, as Etiologic Diagnosis of Athetosis.

Ann Neurosci 2017 May 21;24(1):57-60. Epub 2017 Apr 21.

Interna de Medicina, Universidad de los Andes de Chile, Santiago, Chile.

The Marchiafava-Bignami disease, characterized by demyelination and necrosis of the corpus callosum, has typically been associated with chronic alcohol intake, and clinically has various symptoms and signs. However, several cases have been reported without alcohol association, and these - according to several publications - have some common points, such as preference for female, related to malnutrition, and radiological involvement of the splenium of the corpus callosum. We report a case of a patient with the characteristics described above and whose clinical manifestation was Athetosis. Read More

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http://dx.doi.org/10.1159/000464424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448430PMC
May 2017
8 Reads

A rare case of Marchiafava-Bignami disease: Extracallosal lesions involving bilateral medipeduncle.

Neurol India 2017 May-Jun;65(3):642-643

Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

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http://dx.doi.org/10.4103/neuroindia.NI_365_16DOI Listing
July 2019
53 Reads

Marchiafava-Bignami Disease: A Rare Clinical Dilemma.

J Assoc Physicians India 2017 Mar;65(3):106-107

Professor & Unit Head, Department of Medicine, RNT Medical College, Udaipur, Rajasthan.

Marchiafava-Bignami Disease (MBD) is a progressive neurological disease, characterized by corpus callosal demyelination and necrosis and subsequent atrophy. It is usually seen in the context of alcoholism and malnutrition. Clinical diagnosis of this disease is quite challenging due to various presentations but a high degree of suspicion often leads to the correct diagnosis with help of neuroimaging. Read More

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March 2017
26 Reads

Clinical Reasoning: Corpus callosum lesion with multiple strokes.

Neurology 2017 04;88(14):e137-e142

From the Departments of Neurology (Z.S., N.A., B.R., M.H.) and Pathology (L.S.), Rutgers New Jersey Medical School, Newark, NJ.

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http://dx.doi.org/10.1212/WNL.0000000000003797DOI Listing
April 2017
4 Reads

Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: how poor nutrition contributes to the alcoholic syndrome, as Marchiafava-Bignami disease.

Eur J Clin Nutr 2017 05 22;71(5):580-586. Epub 2017 Feb 22.

Programa de Pós-Graduação em Ciências Farmacêuticas, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brazil.

Ethanol is an important risk factor for the occurrence of several brain disorders that depend on the amount, period and frequency of its consumption. Chronic use of ethanol often leads to the development of neurodegenerative syndromes, which cause morphological and functional impairments such as foetal alcohol syndrome in newborns exposed to ethanol during pregnancy, Wernicke-Korsakoff Syndrome and, more rarely, Marchiafava-Bignami disease (MBD). MBD is characterized by primary degeneration of the corpus callosum, without inflammation and is associated with oxidative stress and hypovitaminosis, as well as altered mental status, to mention dementia, seizures, depression and so on. Read More

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http://dx.doi.org/10.1038/ejcn.2016.267DOI Listing
May 2017
22 Reads

Neuroimaging of chronic alcohol misuse.

J Med Imaging Radiat Oncol 2017 Aug 16;61(4):435-440. Epub 2016 Dec 16.

Neuroradiology and Neurointerventional Service, Department of Radiology, Beaumont Hospital, Beaumont, Ireland.

Alcohol is one of the most commonly abused substances worldwide. It results in a wide range of diseases and disorders affecting many organ systems. Alcohol-related nutritional deficiencies and electrolyte disturbance leave chronic abusers at risk of a range of demyelinating conditions to which the radiologist and clinician should always be alert. Read More

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http://dx.doi.org/10.1111/1754-9485.12572DOI Listing
August 2017
52 Reads
0.951 Impact Factor

Partial interhemispheric disconnection syndrome (P-IHDS) secondary to Marchiafava-Bignami disease type B (MBD-B).

BMJ Case Rep 2016 Nov 23;2016. Epub 2016 Nov 23.

James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, Norfolk, UK.

A 53-year-old man with a 35-year history of excessive alcohol intake presents to our neurology department with 4-year history of progressive neurocognitive deterioration and disconnection syndrome. MRI head demonstrates extensive demyelination of the corpus callosum (and of extracallosal sites as well), leading to a diagnosis of Marchiafava-Bignami disease. He was given treatment with vitamin B complex (including folate) and was assessed and managed by psychology, occupational therapy and physiotherapy with initial signs of improvement. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2016-21682
Publisher Site
http://dx.doi.org/10.1136/bcr-2016-216823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174772PMC
November 2016
28 Reads

Altered Sensorium in a Young Male: Marchiafava Bignami Disease Revisited.

J Assoc Physicians India 2016 11;64(11):86-88

Professor, Dept. of Medicine, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra.

Marchiafava Bignami disease (MBD) is a rare and devastating complication of chronic alcoholism. Degeneration of the corpus callosum is the hallmark feature of MBD. Early diagnosis of MBD by its typical "Sandwich Sign" on magnetic resonance imaging (MRI). Read More

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November 2016
26 Reads

The addicted brain: imaging neurological complications of recreational drug abuse.

Radiologia 2017 Jan - Feb;59(1):17-30. Epub 2016 Oct 20.

Área Clínica de Imagen Médica, Hospital Universitario y Politécnico La Fe, Valencia, España.

Recreational drug abuse represents a serious public health problem. Neuroimaging traditionally played a secondary role in this scenario, where it was limited to detecting acute vascular events. However, thanks to advances in knowledge about disease and in morphological and functional imaging techniques, radiologists have now become very important in the diagnosis of acute and chronic neurological complications of recreational drug abuse. Read More

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http://dx.doi.org/10.1016/j.rx.2016.09.005DOI Listing
April 2018
14 Reads

Marchiafava-Bignami and Alcohol Related Acute Polyneuropathy: The Cooccurrence of Two Rare Entities.

Case Rep Neurol Med 2016 7;2016:5848572. Epub 2016 Sep 7.

Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives. The aim of this article is to represent the first reported case with cooccurrence of two rare alcohol related complications. Case Report. Read More

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http://dx.doi.org/10.1155/2016/5848572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030413PMC
September 2016
27 Reads

Mutism Caused by Severe Demyelination in a Patient With Marchiafava-Bignami Disease.

J Emerg Med 2016 Dec 16;51(6):e129-e132. Epub 2016 Sep 16.

Yale New Haven Hospital, Yale School of Medicine, New Haven, Connecticut; David Geffen School of Medicine at UCLA, Los Angeles, California.

Background: Marchiafava-Bignami (MB) disease is a rare disorder that causes primary degeneration of the corpus callosum. It is associated with chronic alcohol consumption caused by either a toxic or nutritional etiology.

Case Report: We report a case of a 54-year-old woman who presented to our emergency department with complete mutism caused by MB disease that completely resolved with intravenous thiamine and dextrose therapy. Read More

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http://dx.doi.org/10.1016/j.jemermed.2016.07.007DOI Listing
December 2016
10 Reads

Marchiafava-Bignami disease in chronic alcoholic patient.

Radiol Case Rep 2016 Sep 9;11(3):234-7. Epub 2016 Jul 9.

Radiology Department, Medical College Baroda, SSG Hospital, Vadodara, Gujarat, India.

Marchiafava-Bignami disease is a rare toxic encephalopathy seen mostly in chronic alcoholics due to progressive demyelination and necrosis of the corpus callosum. It may involve adjacent white matter and subcortical regions. We present here the magnetic resonance imaging findings of Machiafava-Bignami disease in a chronic alcoholic patient. Read More

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http://dx.doi.org/10.1016/j.radcr.2016.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996925PMC
September 2016
13 Reads

Vegetarian diet and excessive tea consumption: a dangerous association?

Metab Brain Dis 2017 02 15;32(1):271-274. Epub 2016 Aug 15.

Unit of Neurology, Ospedale Bolognini, Seriate, BG, Italy.

Rare metabolic diseases may sometimes arise acutely and endanger human life if not immediately recognized and treated. Marchiafava Bignami disease is an uncommon neurologic disorder described in alcohol abusers and characterized by an acute severe damage of brain white matter. Even more rarely, it has been reported in non-alcohol addicted patients, but never in vegetarian people. Read More

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http://dx.doi.org/10.1007/s11011-016-9893-zDOI Listing
February 2017
16 Reads

[Marchiafava-Bignami disease (Case-report)].

Neuropsychopharmacol Hung 2016 06;18(2):115-8

MH EK Honvédkórház, Pszichiátriai osztály, Budapest, Hungary.

Marchiafava-Bignami disease (MBD) is caused by damage of the corpus callosum. There are acute, subacute and chronic forms, it occurs most frequently among alcoholic patients. A variety of neurological symptoms, epileptic seizures, and coma may be associated with the disease, but the chronic form may start with acute confusion and dementia, interhemispherial disconnection syndrome or with slow progressive changes in behavior. Read More

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June 2016
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Marchiafava-Bignami Disease with frontal cortex involvement and late onset, long-lasting psychiatric symptoms: a case report.

Riv Psichiatr 2016 Mar-Apr;51(2):79-82

Institute of Psychiatry, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy - AOU Maggiore della Carità, Novara, Italy.

Aims: To describe the case and management of a patient with Marchiafava-Bignami Disease (MBD) with frontal cortical lesions, no specific symptom at first referral to the Emergency Room, and late onset of atypical psychiatric symptoms.

Methods: We report the case of a 44-year-old patient with a history of chronic alcohol abuse, eventually diagnosed with MBD.

Results: Magnetic Resonance showed lesions in the splenium and the body of corpus callosum and bilateral lesions of the frontal cortex. Read More

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http://www.rivistadipsichiatria.it/articoli.php?archivio=yes
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http://dx.doi.org/10.1708/2246.24202DOI Listing
August 2017
54 Reads