28,023 results match your criteria Manitoba RN Journal [Journal]


EDTA-Na functionalized FeO nanoparticles: grafting density control for MRSA eradication.

Dalton Trans 2019 Apr 24. Epub 2019 Apr 24.

Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

We report a synthesis strategy to simplify often cumbersome post-synthesis ligand exchange protocols and use that approach to synthesize EDTA-Na3 (N-(trimethoxysilylpropyl)ethylenediaminetriacetate, trisodium salt) functionalized hydrophilic and biocompatible Fe3O4 nanoparticles. The grafting density of EDTA-Na3 has been controlled from 0.07-0. Read More

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http://dx.doi.org/10.1039/c8dt05152fDOI Listing

From the voices of people with haemophilia A and their caregivers: Challenges with current treatment, their impact on quality of life and desired improvements in future therapies.

Haemophilia 2019 Apr 23. Epub 2019 Apr 23.

Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.

Introduction: Haemophilia A is a chronic disease requiring frequent intravenous infusions of recombinant factor VIII. Previous studies have shown that challenges associated with current treatments may have significant impacts on quality of life (QoL) that are as important as the health outcomes conferred by the therapy. Emerging therapeutic innovations offer the potential to mitigate treatment-related challenges, and it is therefore important to develop a better understanding of patient and caregiver experiences with existing haemophilia A treatments in order to characterize the full value of new treatments. Read More

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http://dx.doi.org/10.1111/hae.13754DOI Listing

How to reject Benatar's asymmetry argument.

Authors:
Erik Magnusson

Bioethics 2019 Apr 23. Epub 2019 Apr 23.

Centre for Professional & Applied Ethics, University of Manitoba, Winnipeg, Canada.

In this article I reconsider David Benatar's primary argument for anti-natalism-the asymmetry argument-and outline a three-step process for rejecting it. I begin in Part 2 by reconstructing the asymmetry argument into three main premises. I then turn in Parts 3-5 to explain how each of these premises is in fact false. Read More

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http://dx.doi.org/10.1111/bioe.12582DOI Listing

Which is the preferred site for bone mineral density monitoring as an indicator of treatment-related anti-fracture effect in routine clinical practice? A registry-based cohort study.

Osteoporos Int 2019 Apr 23. Epub 2019 Apr 23.

Department of Medicine (C5121), University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada.

Change in total hip bone mineral density (BMD) provides a robust indication of anti-fracture effect during treatment monitoring in routine clinical practice, whereas spine BMD change is not independently associated with fracture risk.

Purpose: The role of monitoring bone mineral density (BMD) as an indicator of an anti-fracture effect is controversial. Discordance between the spine and hip BMD is common and creates uncertainty in clinical practice. Read More

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http://dx.doi.org/10.1007/s00198-019-04975-yDOI Listing

Summary of the NACI Update on Herpes Zoster Vaccines.

Can Commun Dis Rep 2018 Sep 6;44(9):220-225. Epub 2018 Sep 6.

Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON.

Background: Steep increases in herpes zoster (HZ) incidence, hospitalization due to HZ and the risk of post-herpetic neuralgia as a complication of HZ occur in people over 50 years of age. Two HZ vaccines are currently authorized for use in those 50 years of age and older in Canada: a live attenuated zoster vaccine (LZV) authorized in 2008; and a recombinant subunit vaccine (RZV) authorized in October 2017.

Objectives: To review current evidence and develop guidance on whether the previously authorized LZV (Zostavax) and/or the recently authorized RZV (Shingrix) vaccine should be offered to Canadians 50 years of age and older: 1) at a population-level, in publicly funded immunization programs; and 2) at an individual-level, to individuals wishing to prevent HZ, or by clinicians wishing to advise individual patients about preventing HZ. Read More

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http://dx.doi.org/10.14745/ccdr.v44i09a06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449089PMC
September 2018

Pre-clinical development of a vaccine against Lassa fever.

Can Commun Dis Rep 2018 Jun 7;44(6):139-147. Epub 2018 Jun 7.

Zoonotic Diseases and Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB.

Lassa virus (LASV) is a persistent global health threat that causes about half a million cases of Lassa fever each year in Western Africa. Although most cases are mild, the disease can cause significant morbidity and results in as many as 5,000 deaths per year. Since 2015, Nigeria has been experiencing a severe and extended outbreak of Lassa fever, raising concerns that it could spill over into other countries and reach a magnitude similar to the West African Ebola outbreak of 2013-2016. Read More

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June 2018
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Chlamydia trachomatis Lipopolysaccharide Evades the Canonical and Noncanonical Inflammatory Pathways To Subvert Innate Immunity.

MBio 2019 Apr 23;10(2). Epub 2019 Apr 23.

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

is the most common bacterial cause of sexually transmitted infections. sexually transmitted infections are commonly asymptomatic, implying a pathogenic strategy for the evasion of innate inflammatory immune responses, a paradox as the outer membrane contains lipopolysaccharide (LPS), a known potent agonist of inflammatory innate immunity. Here, we studied the ability of chlamydial LPS to activate the proinflammatory canonical and noncanonical inflammasome pathways in mouse bone marrow-derived macrophages (BMDM). Read More

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http://dx.doi.org/10.1128/mBio.00595-19DOI Listing

DNA Methylation Contributes to the Differential Expression Levels of in Male Mice Neurons and Astrocytes.

Int J Mol Sci 2019 Apr 14;20(8). Epub 2019 Apr 14.

Regenerative Medicine Program, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.

Methyl CpG binding protein-2 (MeCP2) isoforms (E1 and E2) are important epigenetic regulators in brain cells. Accordingly, MeCP2 loss- or gain-of-function mutation causes neurodevelopmental disorders, including Rett syndrome (RTT), duplication syndrome (MDS), and autism spectrum disorders (ASD). Within different types of brain cells, highest MeCP2 levels are detected in neurons and the lowest in astrocytes. Read More

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http://dx.doi.org/10.3390/ijms20081845DOI Listing

Narrow pollen diets are associated with declining Midwestern bumble bee species.

Ecology 2019 Apr 23:e02697. Epub 2019 Apr 23.

Department of Entomology, Michigan State University, East Lansing, Michigan, 48824, USA.

Many species of bumble bee (Bombus) have declined in range and abundance across Europe, the Americas, and Asia, whereas other species have persisted and remain common and widespread. One explanation as to why some species have declined, based primarily on studies of the European bumble bee fauna, is that declining species have relatively narrow pollen-foraging niches and are less able to use alternative host plants in the absence of their preferred hosts. Though extensively explored in Europe, this hypothesis has not been investigated in North America, in part due to incomplete information on the foraging niche of many species. Read More

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http://dx.doi.org/10.1002/ecy.2697DOI Listing

Red blood cell transfusion in critically ill patients with traumatic brain injury: an international survey of physicians' attitudes.

Can J Anaesth 2019 Apr 22. Epub 2019 Apr 22.

CHU de Québec - Université Laval Research Center, Population Health and Optimal Health Practices Research Unit, Traumatology - Emergency - Critical Care Medicine, CHU de Québec-Université Laval (Hôpital de l'Enfant-Jésus), 1401, 18e rue, Québec City, QC, G1J 1Z4, Canada.

Introduction: Restrictive transfusion strategies have been advocated in critically ill patients. Nevertheless, considerable uncertainty exists regarding optimal transfusion thresholds in traumatic brain injury (TBI) patients because the injured brain is susceptible to hypoxemic damage. We aimed to identify the determinants of red blood cell (RBC) transfusion and the perceived optimal transfusion thresholds in adult patients with moderate-to-severe TBI. Read More

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http://dx.doi.org/10.1007/s12630-019-01369-wDOI Listing

Re-imagining miyo-wicehtowin: Human-nature relations, land-making, and wellness among Indigenous youth in a Canadian urban context.

Soc Sci Med 2019 Apr 13;230:122-130. Epub 2019 Apr 13.

Wiyasiwewin Mikiwahp Native Law Centre, College of Law, University of Saskatchewan, Canada.

Relationships to land and nature have long been recognized globally as a central Indigenous determinant of health. As more Indigenous peoples migrate to larger urban centers, it is crucial to better understand how these relationships are maintained or function within urban spaces. This article outlines the results of a year-long collaborative study that qualitatively explored Indigenous young peoples' connections between "land," nature, and wellness in an urban Canadian context. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.04.012DOI Listing

Protein corona variation in nanoparticles revisited: A dynamic grouping strategy.

Colloids Surf B Biointerfaces 2019 Apr 3;179:505-516. Epub 2019 Apr 3.

Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Bio-nano interface investigation models are mainly based on the type of proteins present on corona, bio-nano interaction responses and the evaluation of final outcomes. Due to the extensive diversity in correlative models for investigation of nanoparticles biological responses, a comprehensive model considering different aspects of bio-nano interface from nanoparticles properties to protein corona fingerprints appeared to be essential and cannot be ignored. In order to minimize divergence in studies in the era of bio-nano interface and protein corona with following therapeutic implications, a useful investigation model on the basis of RADAR concept is suggested. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.04.003DOI Listing

Applications of Next-Generation Sequencing for Large-Scale Pathogen Diagnoses in Soybean.

Plant Dis 2019 Apr 22:PDIS05180905RE. Epub 2019 Apr 22.

Department of Biology, Brandon University, Brandon, Manitoba R78 6A9, Canada.

Soybean () has become an important crop in Manitoba, Canada, with a 10-fold increase in dedicated acreage over the past decade. Given the rapid increase in production, scarce information about foliar diseases present in the province has been recorded. In order to describe the foliar pathogens affecting this legume, we harnessed next-generation sequencing (NGS) to carry out a comprehensive survey across Manitoba in 2016. Read More

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http://dx.doi.org/10.1094/PDIS-05-18-0905-REDOI Listing

Congenital Cranial Dysinnervation Disorder: An Unusual Phenotype With Multiple Cranial Neuropathies and Novel Neuroimaging Findings.

J Neuroophthalmol 2019 Apr 16. Epub 2019 Apr 16.

Section of Pediatric Neurology (MSS, SEM), Children's Hospital; Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Section of Pediatric Ophthalmology (CM), Children's Hospital; Department of Ophthalmology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Section of Pediatric Radiology (JW), Children's Hospital; Department of Radiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Congenital cranial dysinnervation disorders result from a maldevelopment of brainstem nuclei and/or cranial nerves. In some cases, specific genetic abnormalities have been identified. We expand the clinical phenotype of these disorders with the report of a 28-month-old girl who was initially evaluated for seizures and was found to have right sixth nerve palsy, small optic discs with reduced vision in her right eye. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000762DOI Listing

The education avenue of the clinical learning environment: A pragmatic approach.

Med Teach 2019 Apr 22:1-7. Epub 2019 Apr 22.

d Formerly Accreditation Council of Graduate Medical Education , Chicago , IL , USA.

Aim: This perspective is part of a series of articles that are outcomes of a consensus conference, that seek to offer a comprehensive examination of the clinical learning environment (CLE), using different academic disciplines and areas of focus termed "avenues." The education dimensions of the CLE are discussed in detail in this perspective, along with critical linkages to the other avenues.

Methods: Using iterative presentations, discussion and small group work, in October 2018, the consensus conference participants explored the education, psychological, sociocultural, diversity and inclusion, digital and architectural aspects of the CLE. Read More

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http://dx.doi.org/10.1080/0142159X.2019.1566602DOI Listing

Airborne Observations of Summer Thinning of Multiyear Sea Ice Originating From the Lincoln Sea.

J Geophys Res Oceans 2019 Jan 14;124(1):243-266. Epub 2019 Jan 14.

Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung Bremerhaven Germany.

To better understand recent changes of Arctic sea ice thickness and extent, it is important to distinguish between the contributions of winter growth and summer melt to the sea ice mass balance. In this study we present a Lagrangian approach to quantify summer sea ice melt in which multiyear ice (MYI) floes that were surveyed by airborne electromagnetic thickness sounding within Nares Strait during summer were backtracked, using satellite imagery, to a region in close proximity (3-20 km) to spring ice thickness surveys carried out in the Lincoln Sea. Typical modal total MYI thicknesses, including ~0. Read More

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http://dx.doi.org/10.1029/2018JC014383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472558PMC
January 2019

The Copyright Issue.

Authors:
Anne Katz

Oncol Nurs Forum 2019 May;46(3):267-268

CancerCare Manitoba.

Do you remember the first (or 40th) time you received notification that a manuscript you submitted to a journal was accepted? Did you dance around your office, yell so loudly that the person in the office next door came to check on you, and/or immediately post the news to Facebook and Twitter to ensure that your success would be broadcast to all your friends and relatives? And did you then download the required forms and merrily sign them before scanning or faxing them back to the journal? Like many of you, I have done all of the above. Read More

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http://dx.doi.org/10.1188/19.ONF.267-268DOI Listing

The role of exercise in improving patient-reported outcomes in individuals on dialysis: A scoping review.

Semin Dial 2019 Apr 21. Epub 2019 Apr 21.

Department of Medicine, University of Alberta, Edmonton, AB, Canada.

Exercise improves objective measures of physical function in individuals on hemodialysis, but its effect on patient-reported outcomes (PROs) is largely unknown. We performed a scoping review to characterize the existing knowledge base on exercise and PROs in dialysis patients to make recommendations for future research. We searched Medline, Embase, Cochrane Database of Systematic Reviews; Cochrane Central Register of Controlled Trials, CINAHL, and SPORT Discus from inception to November 28, 2018 and then screened results for randomized controlled trials comparing aerobic/resistance exercise, or both, with no exercise in individuals on dialysis that reported results of any PRO. Read More

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http://dx.doi.org/10.1111/sdi.12806DOI Listing

The effect of metformin on biomarkers associated with breast cancer outcomes: a systematic review, meta-analysis, and dose-response of randomized clinical trials.

Clin Transl Oncol 2019 Apr 22. Epub 2019 Apr 22.

School of Public Health and Health Management, Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, China.

Purpose: Breast cancer is a leading cause of cancer mortality in developed countries. We performed a meta-analysis of randomized clinical trials to investigate the effect of metformin on biomarkers associated with breast cancer outcomes and to explore the dose-response relationship.

Methods: A systematic search was performed from onset of the database to January 2019 in MEDLINE/PubMed, SCOPUS, and Cochrane library to identify randomized clinical trials investigating the impact of metformin on insulin, glucose, CRP, leptin, body mass indices (BMI), cholesterol, Ki-67, and Homeostatic Model Assessment for Insulin-Resistance (HOMA-IR). Read More

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http://dx.doi.org/10.1007/s12094-019-02108-9DOI Listing

Optimizing confidence in systematic reviews through registration and bias minimization.

Eur Heart J 2019 Apr 21. Epub 2019 Apr 21.

University of Manitoba, College of Medicine, Winnipeg, Canada.

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http://dx.doi.org/10.1093/eurheartj/ehz218DOI Listing

A theory-based, task-oriented, outdoor walking programme for older adults with difficulty walking outdoors: protocol for the Getting Older Adults Outdoors (GO-OUT) randomised controlled trial.

BMJ Open 2019 Apr 20;9(4):e029393. Epub 2019 Apr 20.

College of Kinesiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Introduction: A theory-based, task-oriented, community walking programme can increase outdoor walking activity among older adults to optimise functional independence, social participation and well-being. The study objective is to determine if there is a difference in the change in outdoor walking activity from baseline to 10 weeks, 5.5 months and 12 months after receiving a 1-day interactive workshop and outdoor walking programme (Getting Older Adults Outdoors (GO-OUT)) compared with the workshop and weekly reminders (WR) in older adults with difficulty walking outdoors. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2019-02939
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http://dx.doi.org/10.1136/bmjopen-2019-029393DOI Listing
April 2019
1 Read

Metabolic regulation by the PGC-1α and PGC-1β coactivators in larval zebrafish (Danio rerio).

Comp Biochem Physiol A Mol Integr Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Biology, Brandon University, Brandon, Manitoba R7A 6A9, Canada. Electronic address:

The peroxisome proliferator activated receptor γ coactivator-1 (PGC-1) family is composed of three coactivators whose role in regulating mammalian bioenergetics regulation is clear, but is much less certain in other vertebrates. Current evidence suggests that in fish, PGC-1α and PGC-1β may exhibit much less redundancy in the control of fatty acid oxidation and mitochondrial biogenesis compared to mammals. To assess these roles directly, we knocked down PGC-1α and PGC-1β expression with morpholinos in zebrafish embryos, and we investigated the resulting molecular and physiological phenotypes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10956433183034
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http://dx.doi.org/10.1016/j.cbpa.2019.04.011DOI Listing
April 2019
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Factors Associated With Bone Density Monitoring While on Antiosteoporosis Treatment in Routine Clinical Practice: A Registry-Based Cohort Study.

J Clin Densitom 2019 Mar 21. Epub 2019 Mar 21.

Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

The role for bone mineral density (BMD) monitoring while on antiosteoporosis therapy remains controversial. The current study used population-based registries to identify factors associated with BMD monitoring in women within 5 yr of receiving antiosteoporosis treatment vs treatment without monitoring in routine clinical practice. The analytical dataset consisted of women age 40 yr and older at baseline receiving antiosteoporosis therapy: 6877 with BMD monitoring (mean interval 3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10946950193003
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http://dx.doi.org/10.1016/j.jocd.2019.03.006DOI Listing
March 2019
1 Read

Change in young people's spine pain following chiropractic care at a publicly funded healthcare facility in Canada.

Complement Ther Clin Pract 2019 May 16;35:301-307. Epub 2019 Mar 16.

Manitoba Chiropractors Association, Canadian Chiropractic Association, Canada.

Background: The presence of spinal pain in young people has been established as a risk factor for spinal pain later in life. Recent clinical practice guidelines recommend spinal manipulation (SM), soft tissue therapy, acupuncture, and other modalities that are common treatments provided by chiropractors, as interventions for spine pain. Less is known specifically on the response to chiropractic management in young people with spinal pain. Read More

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http://dx.doi.org/10.1016/j.ctcp.2019.03.013DOI Listing
May 2019
1 Read

How closely do mercury trends in fish and other aquatic wildlife track those in the atmosphere? - Implications for evaluating the effectiveness of the Minamata Convention.

Sci Total Environ 2019 Apr 9;674:58-70. Epub 2019 Apr 9.

Department of Marine Sciences, University of Connecticut, 1080 Shennecossett Road, Groton, CT 06340, USA.

The Minamata Convention to reduce anthropogenic mercury (Hg) emissions entered into force in 2017, and attention is now focused on how to best monitor its effectiveness at reducing Hg exposure to humans. A key question is how closely Hg concentrations in the human food chain, especially in fish and other aquatic wildlife, will track the changes in atmospheric Hg that are expected to occur following anthropogenic emission reductions. We investigated this question by evaluating several regional groups of case studies where Hg concentrations in aquatic biota have been monitored continuously or intermittently for several decades. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.101DOI Listing

First Real-World Safety Analysis of Preschool Peanut Oral Immunotherapy.

J Allergy Clin Immunol Pract 2019 Apr 17. Epub 2019 Apr 17.

British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

Background: In 2017, a clinical trial of 37 subjects demonstrated that preschool peanut oral immunotherapy (P-OIT) was safe, with predominantly mild symptoms reported and only 1 moderate reaction requiring epinephrine.

Objectives: We sought to examine whether these findings would be applicable in a real-world setting.

Methods: As part of a Canada-wide quality improvement project, academic and community allergists administered P-OIT to preschool-age children who had (1) skin prick test wheal diameter greater than or equal to 3 mm or specific IgE level greater than or equal to 0. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.010DOI Listing
April 2019
2 Reads

Novel Measures of Benzodiazepine and Z-Drug Utilisation Trends in a Canadian Provincial Adult Population (2001-2016).

J Popul Ther Clin Pharmacol 2019 Jan 22;26(1):e22-e38. Epub 2019 Jan 22.

College of Pharmacy, University of Manitoba.

Purpose:  1) To evaluate trends for benzodiazepines (BZD) and Z-Drugs over 15-years in a general Canadian adult population measured by: a) consumption b) pharmacologic exposure c) dose intensity and d) prevalence of use. 2) To demonstrate the utility of Diazepam Milligram Equivalence (DME) based measurements when used in conjunction with traditional standard measurements of drug utilization such as the Defined Daily Dose (DDD) system.

Methods: Administrative data covering all prescriptions from April 2001-March 2016 for BZD and Z-Drugs for patients ≥18 years was used. Read More

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http://www.jptcp.com/index.php/jptcp/article/view/52
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http://dx.doi.org/10.22374/1710-6222.26.1.3DOI Listing
January 2019
1 Read

Pfeiffer Syndrome Type 3 and Prune Belly Anomaly in a Female: Case Report and Review.

Fetal Pediatr Pathol 2019 Apr 19:1-6. Epub 2019 Apr 19.

a Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division, Dr. Juan I. Menchaca Civil Hospital of Guadalajara , Guadalajara , Jalisco , Mexico.

Background: Pfeiffer syndrome (PS) is an autosomal dominant entity characterized by craniosynostosis, broad thumbs, and preaxially deviated great toes. It is classified in three types depending on the severity. Type 1: Mild to moderate severity, Type 2: Severe presentation with cloverleaf skull, and Type 3: Severe craniosynostosis with prominent ocular proptosis. Read More

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https://www.tandfonline.com/doi/full/10.1080/15513815.2019.1
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http://dx.doi.org/10.1080/15513815.2019.1603256DOI Listing
April 2019
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Synthesis, Characterization, and Electron-Transfer Properties of Fc-BODIPY-C60 NIR Absorbing Triads: Are Catecholopyrrolidine-Linked Fullerenes a Good Architecture to Facilitate Electron-Transfer?

Chemistry 2019 Apr 18. Epub 2019 Apr 18.

University of Manitoba, Department of Chemistry, 360 Parker Building , R3T 2N2, Winnipeg, CANADA.

A series of covalent Fc-BODIPY-C60 triads with the ferrocene groups conjugated to the BODIPY π-system and the fullerene acceptor linked at the boron hub via a common catecholpyrrolidine bridge were prepared and characterized by spectroscopy, and, for one of the derivatives, X-ray crystallography. Redox processes of the new compounds were investigated by electrochemistry and spectroelectrochemistry. DFT calculations indicate that the HOMO in all triads was delocalized between ferrocene and BODIPY π-system, the LUMO was always fullerene-centered, and the catechol-centered occupied orbital was close in energy to the HOMO. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.2019012
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http://dx.doi.org/10.1002/chem.201901225DOI Listing
April 2019
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Overview of Some Recent Advances in Improving Water and Energy Efficiencies in Food Processing Factories.

Front Nutr 2019 2;6:20. Epub 2019 Apr 2.

Department of Agricultural and Biosystems Engineering, Iowa State University, Ames, IA, United States.

Rapid development of food factories in both developed and developing countries, owing to continued growth in the world population, plays a critical role in the food supply chain, including environmental issues such as pollution, emissions, energy and water consumption, and thus food system sustainability. The objective of this study was to briefly review various environmental aspects of food processing operations, including aquatic, atmospheric, and solid waste generation, and also to discuss several strategies that many companies are using to reduce these negative impacts as well as to improve water and energy efficiency. To obtain higher energy efficiencies in food processing factories, two key operations can play critical roles: non-thermal processing (e. Read More

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http://dx.doi.org/10.3389/fnut.2019.00020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454086PMC
April 2019
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Corrigendum: Intestinal Morphologic and Microbiota Responses to Dietary spp. in a Broiler Chicken Model.

Front Physiol 2019 2;10:332. Epub 2019 Apr 2.

College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.

[This corrects the article DOI: 10.3389/fphys.2018. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00332
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http://dx.doi.org/10.3389/fphys.2019.00332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454220PMC
April 2019
1 Read

Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells.

Cell Death Dis 2019 Apr 18;10(5):337. Epub 2019 Apr 18.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.

Maternal influenza infection during pregnancy was reported multiple times as the possible cause of many defects and congenital anomalies. Apart from several cases of influenza-related miscarriage during various trimesters of pregnancy, some epidemiological data suggest a link between maternal influenza infection and genetic abnormalities in offspring. However, there are no reports yet describing how maternal influenza alters cellular pathways at early stages of development to result in congenital defects in the fetus. Read More

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http://www.nature.com/articles/s41419-019-1567-4
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http://dx.doi.org/10.1038/s41419-019-1567-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472374PMC
April 2019
1 Read

Predicting Motor Outcome in Acute Intracerebral Hemorrhage.

AJNR Am J Neuroradiol 2019 Apr 18. Epub 2019 Apr 18.

Department of Neurology (M.T., J.S., Y.S.), Girona Biomedical Research Institute, Dr Josep Trueta University Hospital, Girona, Spain.

Background And Purpose: Predicting motor outcome following intracerebral hemorrhage is challenging. We tested whether the combination of clinical scores and DTI-based assessment of corticospinal tract damage within the first 12 hours of symptom onset after intracerebral hemorrhage predicts motor outcome at 3 months.

Materials And Methods: We prospectively studied patients with motor deficits secondary to primary intracerebral hemorrhage within the first 12 hours of symptom onset. Read More

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http://www.ajnr.org/lookup/doi/10.3174/ajnr.A6038
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http://dx.doi.org/10.3174/ajnr.A6038DOI Listing
April 2019
1 Read

Characterisation of the volatile flavour compounds in low and high tannin faba beans (Vicia faba var. minor) grown in Alberta, Canada.

Food Res Int 2019 Jun 26;120:285-294. Epub 2019 Feb 26.

Lipid Chemistry Group, Department of Agricultural, Food and Nutrition Sciences, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

The volatile flavour profiles of Canadian-grown faba beans (Vicia faba var. minor) were evaluated by headspace solid-phase microextraction (HS-SPME) coupled to gas chromatography-mass spectrometry (GC-MS). Two low- and high-tannin varieties were chosen, each in the form of dehulled and whole seed flours (DLT, DHT, WLT, and WHT, respectively). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09639969193013
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http://dx.doi.org/10.1016/j.foodres.2019.02.044DOI Listing
June 2019
2 Reads

Habitual Physical Activity in Older Adults Undergoing TAVR: Insights From the FRAILTY-AVR Study.

JACC Cardiovasc Interv 2019 Apr;12(8):781-789

Jewish General Hospital, McGill University, Montreal, Quebec, Canada. Electronic address:

Objectives: The authors sought to assess the distribution and prognostic significance of habitual physical activity (HPA) in older adults undergoing transcatheter aortic valve replacement (TAVR).

Background: Low HPA is associated with mortality and disability in community-dwelling older adults. In the setting of TAVR, it is unclear whether low HPA is a risk factor for downstream morbidity or a byproduct of severe aortic stenosis that improves following its correction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19368798193063
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http://dx.doi.org/10.1016/j.jcin.2019.02.049DOI Listing
April 2019
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The Influence of Diet on MicroRNAs that Impact Cardiovascular Disease.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Institute of Cardiovascular Sciences and the Canadian Centre for Agri-food Research in Health and Medicine (CCARM), Albrechtsen Research Centre, St. Boniface Hospital, Winnipeg, MB R2H2A6, Canada.

Food quality and nutritional habits strongly influence human health status. Extensive research has been conducted to confirm that foods rich in biologically active nutrients have a positive impact on the onset and development of different pathological processes, including cardiovascular diseases. However, the underlying mechanisms by which dietary compounds regulate cardiovascular function have not yet been fully clarified. Read More

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https://www.mdpi.com/1420-3049/24/8/1509
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http://dx.doi.org/10.3390/molecules24081509DOI Listing
April 2019
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Colossal left ventricular apical thrombus.

Clin Case Rep 2019 Apr 3;7(4):846-848. Epub 2019 Mar 3.

Section of Cardiology, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba Winnipeg Manitoba Canada.

Left ventricular apical thrombus is a known complication following an anterior ST-elevation myocardial infarction. Although left ventriculography may suggest an apical thrombus in the presence of a filling defect, additional imaging with echocardiography and/or cardiac magnetic resonance is strongly recommended to further characterize the thrombus post myocardial infarction. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2081
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http://dx.doi.org/10.1002/ccr3.2081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452471PMC
April 2019
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Tuberculosis drug resistance in Canada: 2017.

Can Commun Dis Rep 2018 Nov 1;44(11):290-296. Epub 2018 Nov 1.

Centre for Communicable Disease and Infection Control, Public Health Agency of Canada, Ottawa, ON.

Background: Drug-resistant tuberculosis (TB) is a global public health issue. To monitor this in Canada, surveillance systems have been in place for the last 20 years.

Objective: To describe drug resistance patterns among TB isolates in Canada in 2017 by type of resistance as well as geographic location, demographic data and origin and to compare current data to those of the previous 10 years. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v44i11a04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449088PMC
November 2018
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The National Advisory Committee on Infection Prevention and Control (NAC-IPC).

Can Commun Dis Rep 2018 Nov 1;44(11):283-289. Epub 2018 Nov 1.

University of Manitoba, Winnipeg, MB.

This paper describes the work of the National Advisory Committee on Infection Prevention and Control (NAC-IPC), previously Infection Prevention and Control Expert Working Group, a longstanding external advisory body that provides subject matter expertise and advice to the Public Health Agency of Canada (PHAC) on the prevention and control of infectious diseases in Canadian health care settings. Originally established by Health Canada as the Infection Control Guidelines Steering Committee in 1992, this advisory board has been providing expert advice on infection prevention and control (IPC) guideline development for over 25 years. The NAC-IPC provides advice to inform the development of comprehensive or concise guidelines, quick reference guides and interim guidelines (usually for emerging pathogens), working closely with PHAC's national Healthcare-Associated Infections (HAIs) surveillance programs for Canadian health care facilities. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v44i11a03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449104PMC
November 2018
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Determinants of scholarly project completion in a paediatric resident program in Canada.

Paediatr Child Health 2019 May 28;24(2):e98-e103. Epub 2018 Jun 28.

Department of Paediatrics and Child Health, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba.

Background: The primary aims of this study were to: 1) assess barriers and facilitators of completing scholarly projects from residents and faculty mentor perspectives, 2) determine the perceived value of new initiatives designed to support resident scholarly projects and 3) determine if these initiatives led to changes in resident publications.

Design And Methods: Between June and September 2014, we surveyed 18 paediatric residents and 41 faculty mentors regarding barriers to resident scholarly project completion and the value of new initiatives to support scholarly activity. We also tracked scientific publications by residents before and after implementation of these initiatives. Read More

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https://academic.oup.com/pch/article/24/2/e98/5046549
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http://dx.doi.org/10.1093/pch/pxy089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462124PMC
May 2019
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Scholarly training objectives and requirements for paediatric residents in Canada.

Paediatr Child Health 2019 May 8;24(2):76-80. Epub 2018 Jun 8.

Department of Paediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba.

In the absence of national standards for scholarly requirements, paediatric resident training varies significantly across Canadian programs. This variability may contribute to significant differences in trainee experiences and productivity. A panel of coordinators of paediatric resident research programs from across Canada met in 2014, to share experiences and identify barriers to successful resident scholarly activity. Read More

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http://dx.doi.org/10.1093/pch/pxy070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462126PMC

Publisher Correction: Martian dust storm impact on atmospheric HO and D/H observed by ExoMars Trace Gas Orbiter.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Space Research Institute (IKI), Russian Academy of Sciences (RAS), Moscow, Russia.

The surname of author Cathy Quantin-Nataf was misspelled 'Quantin-Nata' , authors Ehouarn Millour and Roland Young were missing from the ACS Science Team list, and minor changes have been made to the author and affiliation lists; see accompanying Amendment. These errors have been corrected online. Read More

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http://www.nature.com/articles/s41586-019-1163-x
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http://dx.doi.org/10.1038/s41586-019-1163-xDOI Listing
April 2019
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Identification of rare HIV-1-infected patients with extreme CD4+ T cell decline despite ART-mediated viral suppression.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Laboratory of Immunoregulation, HIV Pathogenesis Section, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.

Background: The goal of antiretroviral therapy (ART) is to suppress HIV-1 replication and reconstitute CD4+ T cells. Here, we report on HIV-infected individuals who had a paradoxical decline in CD4+ T cells despite ART-mediated suppression of plasma HIV-1 load (pVL). We defined such an immunological outcome as extreme immune decline (EXID). Read More

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http://dx.doi.org/10.1172/jci.insight.127113DOI Listing
April 2019
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Categorizing and assessing comprehensive drivers of provider behavior for optimizing quality of health care.

PLoS One 2019 17;14(4):e0214922. Epub 2019 Apr 17.

Surgo Foundation, Seattle, Washington, United States of America.

Inadequate quality of care in healthcare facilities is one of the primary causes of patient mortality in low- and middle-income countries, and understanding the behavior of healthcare providers is key to addressing it. Much of the existing research concentrates on improving resource-focused issues, such as staffing or training, but these interventions do not fully close the gaps in quality of care. By contrast, there is a lack of knowledge regarding the full contextual and internal drivers-such as social norms, beliefs, and emotions-that influence the clinical behaviors of healthcare providers. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214922PLOS

Brief interventions for problem gambling: A meta-analysis.

PLoS One 2019 17;14(4):e0214502. Epub 2019 Apr 17.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada.

Background: Brief interventions have been increasingly investigated to promote early intervention in gambling problems; an accurate estimate of the impact of these interventions is required to justify their widespread implementation. The goal of the current investigation was to evaluate the efficacy of in-person brief interventions for reducing gambling behaviour and/or problems, by quantifying the aggregate effect size associated with these interventions in the published literature to date.

Methods: Randomized controlled trials including the following design features were identified via systematic review: an adult sample experiencing problems associated with gambling; an in-person individual psychosocial intervention of brief duration (≤3 sessions); a control/comparison group; and an outcome related to gambling behaviour and/or problems. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214502PLOS
April 2019
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Screen-time is associated with inattention problems in preschoolers: Results from the CHILD birth cohort study.

PLoS One 2019 17;14(4):e0213995. Epub 2019 Apr 17.

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Background: Pre-school children spend an average of two-hours daily using screens. We examined associations between screen-time on pre-school behavior using data from the Canadian Healthy Infant Longitudinal Development (CHILD) study.

Methods: CHILD participant parents completed the Child Behavior Checklist (CBCL) at five-years of age. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213995PLOS
April 2019
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3.234 Impact Factor

Dignity Therapy Led by Nurses or Chaplains for Elderly Cancer Palliative Care Outpatients: Protocol for a Randomized Controlled Trial.

JMIR Res Protoc 2019 Apr 17;8(4):e12213. Epub 2019 Apr 17.

Center for Palliative Care Research and Education, College of Nursing, University of Florida, Gainesville, FL, United States.

Background: Our goal is to improve psychosocial and spiritual care outcomes for elderly patients with cancer by optimizing an intervention focused on dignity conservation tasks such as settling relationships, sharing words of love, and preparing a legacy document. These tasks are central needs for elderly patients with cancer. Dignity therapy (DT) has clear feasibility but inconsistent efficacy. Read More

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https://www.researchprotocols.org/2019/4/e12213/
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http://dx.doi.org/10.2196/12213DOI Listing
April 2019
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A retrospective cohort study comparing non-fatal self-harm emergency department visits between Canadian veterans living in Ontario and matched civilians.

Int Rev Psychiatry 2019 Apr 17:1-9. Epub 2019 Apr 17.

d IC/ES , Toronto , Canada.

This was a retrospective cohort study linking provincial administrative databases to compare rates of non-fatal self-harm between CAF and RCMP veterans living in Ontario and age-matched civilians. This study included male veterans who registered for provincial health insurance between 2002 and 2013. A civilian comparator group was matched 4:1 on age and sex. Read More

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http://dx.doi.org/10.1080/09540261.2019.1580685DOI Listing