27,587 results match your criteria Manitoba RN Journal [Journal]


Assessing image artifacts from radiotherapy electromagnetic transponders with metal-artifact reduction imaging.

Magn Reson Imaging 2019 Feb 17. Epub 2019 Feb 17.

Department of Physics & Astronomy, University of Manitoba, Canada; Medical Physics, CancerCare Manitoba, Canada.

Image artifacts due to 14 gauge radiotherapy electromagnetic (EM) transponders were assessed on conventional spin echo images, and corrected using metal artifact reduction techniques: high bandwidth, view angle tilting (VAT), and slice encoding for metal artifact correction (SEMAC). Large areas of signal loss and/or pile-up were produced in an area extending up to 15.3 mm in radius for 14G transponders in standard imaging. Read More

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http://dx.doi.org/10.1016/j.mri.2019.02.005DOI Listing
February 2019

Research Citation Analysis of Canadian Nursing Academics: 9-year Follow-Up.

J Adv Nurs 2019 Feb 20. Epub 2019 Feb 20.

Red Deer College, Red Deer, Alberta, Canada.

The present study is a follow-up to an analysis of research citations of nursing academics in Canada that was conducted in 2009 (Hack et al., 2010). The goal of this earlier research was to describe the research publication productivity of these individuals using citation analysis, and in so doing, both honour these individuals and promote nursing research scholarship. Read More

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http://dx.doi.org/10.1111/jan.13977DOI Listing
February 2019

Evaluating Information Quality of Revised Patient Education Information on Colonoscopy: It Is New But Is It Improved?

Interact J Med Res 2019 Feb 20;8(1):e11938. Epub 2019 Feb 20.

Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada.

Background: Previous research indicates that patients and their families have many questions about colonoscopy that are not fully answered by existing resources. We developed revised forms on colonoscopy bowel preparation and on the procedure itself.

Objective: As the goal of the revised materials is to have improved information relative to currently available information, we were interested in how revised information compared with what is currently available in terms of information quality and patient preference. Read More

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http://dx.doi.org/10.2196/11938DOI Listing
February 2019

Role of thoracic consolidation radiation in extensive stage small cell lung cancer: A systematic review and meta-analysis of randomised controlled trials.

Eur J Cancer 2019 Feb 18;110:110-119. Epub 2019 Feb 18.

Department of Radiation Oncology, CancerCare Manitoba and University of Manitoba, Winnipeg, Manitoba, Canada.

Extensive stage small cell lung cancer (ES-SCLC) carries a poor prognosis, and the thoracic progression is common. Consolidation radiation to thoracic disease (cRT) could improve progression-free survival (PFS) and overall survival (OS). We conducted an electronic search of PubMed and Embase with no language, year or publication status restrictions and evaluated randomised controlled trials (RCTs) addressing the role of cRT in ES-SCLC. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.01.003DOI Listing
February 2019

Report of a KPC-producing Pseudomonas aeruginosa isolate in Canada.

J Antimicrob Chemother 2019 Feb 19. Epub 2019 Feb 19.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

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http://dx.doi.org/10.1093/jac/dkz064DOI Listing
February 2019

Molecular basis for the potent inhibition of the emerging carbapenemase VCC-1 by avibactam.

Antimicrob Agents Chemother 2019 Feb 19. Epub 2019 Feb 19.

Department of Microbiology, University of Manitoba, Winnipeg, Canada, R3T 2N2

In 2016 we identified a new class A carbapenemase, VCC-1, in nontoxigenic that had been isolated from retail shrimp imported into Canada for human consumption. Shortly thereafter, seven additional VCC-1 producing were isolated along the German coastline. These isolates appear to have acquired the VCC-1 gene () independently from the Canadian isolate, suggesting is mobile and widely distributed. Read More

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http://dx.doi.org/10.1128/AAC.02112-18DOI Listing
February 2019

Dairy product consumption and development of cancer: an overview of reviews.

BMJ Open 2019 Jan 25;9(1):e023625. Epub 2019 Jan 25.

The George & Fay Yee Center for Healthcare Innovation, University of Manitoba, Winnipeg, Manitoba, Canada.

Objectives: To provide a comprehensive systematic overview of current evidence from pooled analyses/meta-analyses and systematic reviews (PMASRs) pertaining to dairy consumption and incident cancer and/or all-cause or cancer-specific mortality.

Design: Overview of reviews.

Setting: Community setting. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023625DOI Listing
January 2019

Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health.

Authors:
C Dawes D T W Wong

J Dent Res 2019 Feb;98(2):133-141

2 Center for Oral/Head and Neck Oncology Research, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA, USA.

The objective of this article was to provide an account of some of the developments related to saliva over the first 100 years of the Journal of Dental Research and to outline some of the many biomarkers identified in saliva in the last few years. The first section covers findings in salivary physiology, biochemistry, calcium phosphate chemistry related to saliva, microbiology, and the role of saliva in maintaining oral health. The second section highlights salivary diagnostics, salivaomics, and saliva exosomics in the context of the emerging theme of personalized and precision medicine. Read More

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http://dx.doi.org/10.1177/0022034518816961DOI Listing
February 2019

The Journal of Dental Research: A Century of Shaping the Dental, Oral, and Craniofacial Sciences.

J Dent Res 2019 Jan;98(1):5-6

5 School of Dentistry, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1177/0022034518817720DOI Listing
January 2019

Induced Resistance to Blackleg (Leptosphaeria maculans) Disease of Canola (Brassica napus) Caused by a Weakly Virulent Isolate of Leptosphaeria biglobosa.

Plant Dis 2006 Aug;90(8):1059-1064

Department of Plant Science, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.

Blackleg of canola is a disease complex of at least two fungal species: Leptosphaeria maculans and L. biglobosa. Isolates of L. Read More

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http://dx.doi.org/10.1094/PD-90-1059DOI Listing

First Report of "Candidatus Phytoplasma asteris"-Related Strains in Brassica rapa in Saskatchewan, Canada.

Plant Dis 2006 Jun;90(6):832

AAFC-ECORC, Ottawa, ON, K1A OC6 Canada.

"Candidatus phytoplasma asteris" and related strains (i.e., aster yellows group 16SrI) have been associated with diseases of numerous plant species worldwide. Read More

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http://dx.doi.org/10.1094/PD-90-0832CDOI Listing

First Report on the Presence of Phoma Blackleg Pathogenicity Group 1 (Leptosphaeria biglobosa) on Brassica napus (Canola/Rapeseed) in Iran.

Plant Dis 2007 Apr;91(4):465

Agricultural and Natural Resources Research Center of Golestan Province of Iran, Gorgan, Iran.

Canola/rapeseed (Brassica napus L.) is a new crop in Iran, grown since 1996. In 2006, 180,000 ha were planted. Read More

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http://dx.doi.org/10.1094/PDIS-91-4-0465ADOI Listing

First Report of Pathogenicity Group-3 of Leptosphaeria maculans on Winter Rape in Hungary.

Plant Dis 2006 May;90(5):684

Department of Plant Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

Blackleg, caused by Leptosphaeria maculans, is an increasing threat to winter rape (Brassica napus L.) in Hungary. The winter rape acreage has been increasing, and the occurrence and severity of the disease has become widespread in all rapeseed-growing regions throughout Hungary in a very short time. Read More

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http://dx.doi.org/10.1094/PD-90-0684CDOI Listing

Genetic Diversity of Gibberella zeae Isolates from Manitoba.

Plant Dis 2006 Oct;90(10):1337-1342

Cereal Research Centre, Agriculture and Agri-Food Canada, Winnipeg, MB R3T 2M9, Canada.

Gibberella zeae (anamorph Fusarium graminearum) causes Fusarium head blight, one of the most important diseases of cereals in the Canadian prairies for the last decade. In 2002, 60 isolates of G. zeae were collected and single spored from naturally infected spikes of wheat from Carman and Winnipeg in Manitoba. Read More

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http://dx.doi.org/10.1094/PD-90-1337DOI Listing
October 2006

Virulence Diversity in the Population of Bipolaris sorokiniana.

Authors:
H Ghazvini A Tekauz

Plant Dis 2007 Jul;91(7):814-821

Cereal Research Centre, Agriculture and Agri-Food Canada, 195 Dafoe Road, Winnipeg, MB R3T 2M9, Canada.

Spot blotch, caused by Bipolaris sorokiniana, is a damaging disease of barley in Canada, especially in the prairie region (Manitoba, Saskatchewan, and Alberta) where most of Canadian crops are produced. Considerable interaction between isolates of the pathogen and barley genotypes necessitates the evaluation of the virulence diversity in the B. sorokiniana population in order to deploy effective resistance against the pathogen. Read More

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http://dx.doi.org/10.1094/PDIS-91-7-0814DOI Listing

Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer.

Cells 2019 Feb 16;8(2). Epub 2019 Feb 16.

Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.

Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes such as gene transcription and DNA damage repair. Importantly, the cellular machinery regulating histone ubiquitination is frequently altered in cancers. Moreover, aberrant histone ubiquitination can drive oncogenesis by altering the expression of tumor suppressors and oncogenes, misregulating cellular differentiation and promoting cancer cell proliferation. Read More

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http://dx.doi.org/10.3390/cells8020165DOI Listing
February 2019

Detecting Chromosome Instability in Cancer: Approaches to Resolve Cell-to-Cell Heterogeneity.

Cancers (Basel) 2019 Feb 15;11(2). Epub 2019 Feb 15.

Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.

Chromosome instability (CIN) is defined as an increased rate of chromosome gains and losses that manifests as cell-to-cell karyotypic heterogeneity and drives cancer initiation and evolution. Current research efforts are aimed at identifying the etiological origins of CIN, establishing its roles in cancer pathogenesis, understanding its implications for patient prognosis, and developing novel therapeutics that are capable of exploiting CIN. Thus, the ability to accurately identify and evaluate CIN is critical within both research and clinical settings. Read More

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http://dx.doi.org/10.3390/cancers11020226DOI Listing
February 2019

Detection of municipalities at-risk of Lyme disease using passive surveillance of Ixodes scapularis as an early signal: A province-specific indicator in Canada.

PLoS One 2019 19;14(2):e0212637. Epub 2019 Feb 19.

Policy Integration and Zoonoses Division, Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint-Hyacinthe, Québec, Canada.

Lyme disease, the most commonly reported vector-borne disease in North America, is caused by the spirochete Borrelia burgdorferi sensu stricto, which is transmitted by Ixodes scapularis in eastern Canada and Ixodes pacificus in western Canada. Recently, the northward range expansion of I. scapularis ticks, in south-eastern Canada, has resulted in a dramatic increase in the incidence of human Lyme disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212637PLOS
February 2019
1 Read

Effects of spinal immobilization and spinal motion restriction on head-neck kinematics during ambulance transport.

Prehosp Emerg Care 2019 Feb 19:1-12. Epub 2019 Feb 19.

g University of Winnipeg , Gupta Faculty of Kinesiology and Applied Health , 515 Portage Avenue , Winnipeg , Manitoba , R3B 2E9 Canada.

Objective: To determine the influence of ambulance motion on head-neck (H-N) kinematics and to compare the effectiveness of two spinal precaution (SP) protocols: spinal immobilization (SI) and spinal motion reduction (SMR).

Methods: Eighteen healthy volunteers (7 females) underwent a series of standardized ambulance transport tasks, across various speeds, under the two SP protocols in a balanced order (n = 12 drivers, n = 7 ambulances). Inertial measurement units were placed on participants' heads and sternums, with another affixed to the stretcher mattress frame. Read More

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http://dx.doi.org/10.1080/10903127.2019.1584833DOI Listing
February 2019

Higher fat stores contribute to persistence of little brown bat populations with white-nose syndrome.

J Anim Ecol 2019 Feb 18. Epub 2019 Feb 18.

Department of Ecology and Evolutionary Biology, University of California, UC Santa Cruz, California.

The persistence of populations declining from novel stressors depends, in part, on their ability to respond by trait change via evolution or plasticity. White-nose syndrome (WNS) has caused rapid declines in several North America bat species by disrupting hibernation behaviour, leading to body fat depletion and starvation. However, some populations of Myotis lucifugus now persist with WNS by unknown mechanisms. Read More

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http://dx.doi.org/10.1111/1365-2656.12954DOI Listing
February 2019

An Examination of Comorbid Psychiatric Disorders in Disordered Gamblers Versus Other Substance-Related Disorders.

J Gambl Stud 2019 Feb 18. Epub 2019 Feb 18.

Departments of Psychiatry, Psychology, and Community Health Sciences, University of Manitoba, Winnipeg, Canada.

Substantial changes were made with the creation of the Substance Related and Addictive Disorders category in the fifth edition of the Diagnostic and Statistical Manual (DSM-5; APA in Diagnostic and statistical manual of mental disorders, 5th edn, American Psychiatric Publishing, Arlington, 2013a), including the addition of gambling disorder to the category and a reduction in the minimum threshold of diagnostic criteria required for a gambling disorder. As gambling shares many similarities with substance use disorders, it stands to reason that comorbidity rates of other psychiatric disorders would be similar among gambling and substance use disorders. The current study examines whether changes in gambling diagnostic criteria from DSM-IV to DSM-5 correspond to changes in prevalence of comorbid psychiatric disorders among disordered gamblers that result in prevalence rates more similar to those observed in alcohol and cannabis use disorders. Read More

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http://dx.doi.org/10.1007/s10899-019-09839-yDOI Listing
February 2019

Silver nanoparticles present high intracellular and extracellular killing against Staphylococcus aureus.

J Antimicrob Chemother 2019 Feb 18. Epub 2019 Feb 18.

Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV, USA.

Objectives: Bone and joint infections caused by Staphylococcus aureus are becoming increasingly difficult to treat due to rising antibiotic resistance, resilient biofilms and intracellular survival of S. aureus. It has been challenging to identify and develop antimicrobial agents that can be used to kill extracellular and intracellular bacteria while having limited toxicity towards host cells. Read More

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http://dx.doi.org/10.1093/jac/dkz053DOI Listing
February 2019

A Cholesterol Analog Induces an Oligomeric Reorganization of VDAC.

Biophys J 2019 Feb 1. Epub 2019 Feb 1.

Departments of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada; Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

The oligomeric organization of the voltage-dependent anion-selective channel (VDAC) and its interactions with hexokinase play integral roles in mitochondrially mediated apoptotic signaling. Various small to large assemblies of VDAC are observed in mitochondrial outer membranes, but they do not predominate in detergent-solubilized VDAC samples. In this study, a cholesterol analog, cholesteryl-hemisuccinate (CHS), was shown to induce the formation of detergent-soluble VDAC multimers. Read More

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http://dx.doi.org/10.1016/j.bpj.2019.01.031DOI Listing
February 2019

The Second Victim Phenomenon: Perspective of Canadian Radiation Therapists.

J Med Imaging Radiat Sci 2019 Mar 24;50(1):87-97. Epub 2018 Aug 24.

Head and Medical Director, Radiation Oncology Program, CancerCare Manitoba, University Manitoba, Winnipeg, Manitoba, Canada.

Introduction: Clinical incidents are an unfortunate reality in the health care system. Patients and their families are the first victims of these incidents. The health care providers involved in the error are considered the second victims. Read More

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http://dx.doi.org/10.1016/j.jmir.2018.07.004DOI Listing

Attitudes faced by young adults using assistive technology as depicted through photovoice.

Disabil Rehabil Assist Technol 2019 Feb 19:1-8. Epub 2019 Feb 19.

a Department of Occupational Therapy, College of Rehabilitation Sciences, Rady Faculty of Health Sciences , University of Manitoba , Winnipeg , Canada.

Purpose: To explore how the attitudinal environment influences the participation experiences of young adults with disabilities who use assistive technology.

Methods: In this qualitative study, twenty young adults using assistive technology completed individual interviews before and after engaging in a photovoice process. Ten of the participants then took part in a focus group. Read More

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https://www.tandfonline.com/doi/full/10.1080/17483107.2019.1
Publisher Site
http://dx.doi.org/10.1080/17483107.2019.1571118DOI Listing
February 2019
1 Read

Arthroscopic Hill-Sachs Remplissage with Bankart Repair: Strategy and Technique.

JBJS Essent Surg Tech 2014 Mar 26;4(1):e4. Epub 2014 Feb 26.

Department of Orthopaedics and Traumatology, University of Bern, Inselspital, 3010 Bern, Switzerland.

Introduction: Arthroscopic Hill-Sachs remplissage describes the fixation of the posterior aspect of the capsule and the infraspinatus tendon into a posterosuperior humeral head impaction fracture in cases of recurrent anteroinferior glenohumeral instability.

Step 1 Anterior Capsulolabral Mobilization And Glenoid Preparation: Perform diagnostic arthroscopy through a standard posterior portal to rule out additional pathology and document the "engaging" nature of the Hill-Sachs defect.

Step 2 Preparation Of The Hill-sachs Defect: With the camera remaining in the posterior portal, the assistant provides visualization of the Hill-Sachs defect by translating the humeral head anteriorly over the glenoid rim with direct pressure on the proximal part of the humerus. Read More

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http://dx.doi.org/10.2106/JBJS.ST.M.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355037PMC

Vehicle routing for a mid-day meal delivery distribution system.

Heliyon 2019 Jan 29;5(1):e01158. Epub 2019 Jan 29.

Indian Institute of Management Jammu, Canal Road, Jammu, 180016, India.

This paper considers the distribution system of a school feeding program (mid-day meals), wherein a set of delivery vehicles transfer cooked food from a kitchen facility to various schools within a specified delivery deadline. The food is required to be delivered before the lunch period, which is consistent across all the schools. A delay in food delivery can deprive students of their lunch, and, therefore, designing the vehicle routes for such distribution systems and maintaining a strict delivery deadline becomes critical. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356091PMC
January 2019

A recombinant vesicular stomatitis-based Lassa fever vaccine elicits rapid and long-term protection from lethal Lassa virus infection in guinea pigs.

NPJ Vaccines 2019 8;4. Epub 2019 Feb 8.

1Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB Canada.

The World Health Organization has identified Lassa virus (LASV) as one of the top five pathogens to cause a severe outbreak in the near future. This study assesses the ability of a leading vaccine candidate, recombinant Vesicular stomatitis virus expressing LASV glycoprotein (VSVΔG/LASVGPC), and its ability to induce rapid and long-term immunity to lethal guinea pig-adapted LASV (GPA-LASV). Outbred guinea pigs were vaccinated with a single dose of VSVΔG/LASVGPC followed by a lethal challenge of GPA-LASV at 7, 14, 25, 189, and 355 days post-vaccination. Read More

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http://dx.doi.org/10.1038/s41541-019-0104-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368541PMC
February 2019

Health-related quality of life worsens by school age amongst children with food allergy.

Clin Transl Allergy 2019 7;9:10. Epub 2019 Feb 7.

1The Centre for Allergy Research, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden.

Background: Food allergy is negatively associated with health-related quality of life (HRQL). Although differences exist between parents and children, less is known about age-specific differences amongst children. As such, we aimed to identify if age, as well as other factors, are associated with food allergy-specific HRQL in an objectively defined population of children. Read More

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http://dx.doi.org/10.1186/s13601-019-0244-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366088PMC
February 2019

Clinical Characteristics and Prognosis of Primary Tracheal Cancer: A Single Institution Experience.

Int J Hematol Oncol Stem Cell Res 2018 Oct;12(4):298-302

Department of Radiation Oncology, Cancer Care Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada.

Primary tracheal cancers (PTCs) are rare and current evidence-based understanding is limited to retrospective reports and national databases. We present single institutional study of a historical cohort of PTC from Canadian provincial cancer registry database. After institutional research ethics board approval, all PTC patients diagnosed from 1980 to 2014 were identified through the Canadian provincial cancer registry. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375374PMC
October 2018
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Diets Enriched with Conventional or High-Oleic Acid Canola Oils Lower Atherogenic Lipids and Lipoproteins Compared to a Diet with a Western Fatty Acid Profile in Adults with Central Adiposity.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Departments of Food and Human Nutritional Sciences, Winnipeg, MB, Canada.

Background: Novel oils high in monounsaturated fatty acids (MUFAs) and low in saturated fatty acids (SFAs) are an alternative to partially hydrogenated oils high in trans-unsaturated fatty acids. There is widespread use of high-MUFA oils across the food industry; however, limited knowledge of their cardiovascular impact exists.

Objectives: We investigated the effects of diets containing canola oil, high-oleic acid canola oil (HOCO), and a control oil blend (diet formulated to emulate a Western fat profile) on lipids, lipoproteins, and apolipoproteins (apos), as secondary outcomes of the trial. Read More

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http://dx.doi.org/10.1093/jn/nxy307DOI Listing
February 2019

Events Within the First Year of Life, but not the Neonatal Period, Affect Risk for Later Development of Inflammatory Bowel Diseases.

Gastroenterology 2019 Feb 14. Epub 2019 Feb 14.

Manitoba Centre for Health Policy; Department of Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Background & Aims: We performed a population-based study to determine whether there was an increased risk of inflammatory bowel diseases (IBD) in persons with critical events at birth and within 1 year of age.

Methods: We collected data from the University of Manitoba IBD Epidemiology Database, which contains records on all Manitobans diagnosed with IBD from 1984 through 2010 and matched controls. From 1970 individuals' records can be linked with those of their mothers, so we were able to identify siblings. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.02.004DOI Listing
February 2019
1 Read

Mortinaissance attribuable à l'ulcération du cordon ombilical.

J Obstet Gynaecol Can 2019 Feb 13. Epub 2019 Feb 13.

Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynaecology, and Reproductive Sciences, University of Manitoba, Winnipeg, MB.

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http://dx.doi.org/10.1016/j.jogc.2019.01.005DOI Listing
February 2019

Stillbirth Due to Umbilical Cord Erosion.

J Obstet Gynaecol Can 2019 Feb 13. Epub 2019 Feb 13.

Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynaecology, and Reproductive Sciences, University of Manitoba, Winnipeg, MB.

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http://dx.doi.org/10.1016/j.jogc.2018.11.006DOI Listing
February 2019

Somatotopic organization of the human spinothalamic tract: in vivo computed tomography-guided mapping in awake patients undergoing cordotomy.

J Neurosurg Spine 2019 Feb 15:1-7. Epub 2019 Feb 15.

3Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.

OBJECTIVEThe location of the human spinothalamic tract (STT) in the anterolateral spinal cord has been known for more than a century. The exact nature of the neuronal fiber lamination within the STT, however, remains controversial. After correlating in vivo macrostimulation-induced pain/temperature sensation during percutaneous cervical cordotomy with simultaneous CT imaging of the electrode tip location, the authors present a modern description of the somatotopy of the human cervical STT. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE18172DOI Listing
February 2019

Genome-wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood.

Am J Phys Anthropol 2019 Feb 16. Epub 2019 Feb 16.

Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada.

Objectives: Socioeconomic status (SES) is a powerful determinant of health, but the underlying biological mechanisms are poorly understood. This study investigates whether levels of DNA methylation at CpG sites across the genome are associated with SES in a cohort of young adults in the Philippines.

Methods: DNA methylation was assayed with the Illumina HumanMethylation450 Bead Chip, in leukocytes from 489 participants in the Cebu Longitudinal Health and Nutrition Survey (mean age = 20. Read More

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http://dx.doi.org/10.1002/ajpa.23800DOI Listing
February 2019
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Weak effects of geolocators on small birds: a meta-analysis controlled for phylogeny and publication bias.

J Anim Ecol 2019 Feb 16. Epub 2019 Feb 16.

The Czech Academy of Sciences, Institute of Vertebrate Biology, Květná 8, 603 65, Brno, Czech Republic.

Currently, the deployment of tracking devices is one of the most frequently used approaches to study movement ecology of birds. Recent miniaturisation of light-level geolocators enabled studying small bird species whose migratory patterns were widely unknown. However, geolocators may reduce vital rates in tagged birds and may bias obtained movement data. Read More

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http://dx.doi.org/10.1111/1365-2656.12962DOI Listing
February 2019
1 Read

Evaluating the properties of a frailty index and its association with mortality risk among patients with systemic lupus erythematosus.

Arthritis Rheumatol 2019 Feb 16. Epub 2019 Feb 16.

Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Center and Dalhousie University, Halifax, Nova Scotia, Canada.

Objective: To evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in SLE.

Methods: For this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/ACR Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36]) were assessed. The SLICC-FI was constructed using baseline data. Read More

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http://doi.wiley.com/10.1002/art.40859
Publisher Site
http://dx.doi.org/10.1002/art.40859DOI Listing
February 2019
2 Reads

Validation of an algorithm for identifying MS cases in administrative health claims datasets.

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Veterans Affairs Post Deployment Health Services (W.J.C., M.T.W.), Multiple Sclerosis Center of Excellence; University of Maryland (W.J.C.), Baltimore; Departments of Internal Medicine and Community Health Sciences (R.A.M., S.L.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Neurology Department (A.L.-G., L.H.C.), Kaiser Permanente Southern California, Los Angeles; Georgetown University School of Medicine (M.T.W.), Washington, DC; University of Colorado (J.C.), Denver; Stanford University School of Medicine (L.M.N.), CA; McKing Consulting Corp (W.E.K., L.W.), Atlanta, GA; Faculty of Medicine (Neurology) and Centre for Brain Health (H.T.), University of British Columbia, Vancouver; College of Pharmacy and Nutrition (C.E.), University of Saskatchewan; Health Quality Council (Saskatchewan) (S.Y.), Saskatoon, Canada; and National Multiple Sclerosis Society (N.G.L.), New York, NY.

Objective: To develop a valid algorithm for identifying multiple sclerosis (MS) cases in administrative health claims (AHC) datasets.

Methods: We used 4 AHC datasets from the Veterans Administration (VA), Kaiser Permanente Southern California (KPSC), Manitoba (Canada), and Saskatchewan (Canada). In the VA, KPSC, and Manitoba, we tested the performance of candidate algorithms based on inpatient, outpatient, and disease-modifying therapy (DMT) claims compared to medical records review using sensitivity, specificity, positive and negative predictive values, and interrater reliability (Youden J statistic) both overall and stratified by sex and age. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007043DOI Listing
February 2019

The prevalence of MS in the United States: A population-based estimate using health claims data.

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Veterans Affairs Multiple Sclerosis Center of Excellence (M.T.W., W.J.C.); Georgetown University School of Medicine (M.T.W.), Washington, DC; University of Maryland (W.J.C.), Baltimore; University of Colorado (J.D.C., P.D.), Aurora; Stanford University School of Medicine (L.M.N., B.T.), CA; Southern California Permanente Medical Group (A.L.-G., L.H.C.), Pasadena; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; University of Alabama at Birmingham (G.R.C.); McKing Consulting Corp (W.E.K., L.W.), Atlanta, GA; Faculty of Medicine (Neurology) and Centre for Brain Health (H.T.), University of British Columbia, Vancouver, Canada; Brown University (S.L.B.), Providence, RI; and National Multiple Sclerosis Society (N.G.L.), New York, NY.

Objective: To generate a national multiple sclerosis (MS) prevalence estimate for the United States by applying a validated algorithm to multiple administrative health claims (AHC) datasets.

Methods: A validated algorithm was applied to private, military, and public AHC datasets to identify adult cases of MS between 2008 and 2010. In each dataset, we determined the 3-year cumulative prevalence overall and stratified by age, sex, and census region. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007035DOI Listing
February 2019
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A new way to estimate neurologic disease prevalence in the United States: Illustrated with MS.

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Division of Epidemiology, Department of Health Research and Policy (L.M.N.), Stanford University School of Medicine, Stanford, CA; Department of Veterans Affairs Multiple Sclerosis Center of Excellence (VA MSCoE) and Georgetown University School of Medicine (M.T.W.), Washington, DC; Department of Internal Medicine (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; VA MS Center of Excellence and University of Maryland (W.J.C.), Baltimore; Neurology Department (A.L.-G.), Kaiser Permanente Southern California, Los Angeles; University of Colorado (J.C.), Denver; Brown University (S.B.), Providence, RI; University of British Columbia (H.T.), Vancouver, Canada; University of Alabama at Birmingham (G.C.); McKing Consulting Corporation (W.K., L.W.), Atlanta, GA; and National Multiple Sclerosis Society (N.G.L.), New York, NY.

Objective: Considerable gaps exist in knowledge regarding the prevalence of neurologic diseases, such as multiple sclerosis (MS), in the United States. Therefore, the MS Prevalence Working Group sought to review and evaluate alternative methods for obtaining a scientifically valid estimate of national MS prevalence in the current health care era.

Methods: We carried out a strengths, weaknesses, opportunities, and threats (SWOT) analysis for 3 approaches to estimate MS prevalence: population-based MS registries, national probability health surveys, and analysis of administrative health claims databases. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007044DOI Listing
February 2019

Access to Hematopoietic Stem Cell Transplantation among Pediatric Patients with Acute Lymphoblastic Leukemia: A Population-based Analysis.

Biol Blood Marrow Transplant 2019 Feb 12. Epub 2019 Feb 12.

Division of Hematology/Oncology, Hospital for Sick Children, Toronto, Ontario.

Introduction: Access to hematopoietic stem cell transplantation (HSCT) in pediatric acute lymphoblastic leukemia (ALL) is primarily dependent on disease-related factors but may be influenced by social and economic determinants.

Methods: We included all children < 15 years old with newly diagnosed ALL in Canada between 2001 and 2018 using the Cancer in Young People in Canada (CYP-C) national registry. We examined factors potentially associated with the likelihood of receiving HSCT using univariate and multivariable logistic regression models. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10838791193013
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http://dx.doi.org/10.1016/j.bbmt.2019.02.009DOI Listing
February 2019
3 Reads

Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease.

Free Radic Biol Med 2019 Feb 12;134:567-580. Epub 2019 Feb 12.

Regenerative Medicine Program and Spinal Cord Research Centre, Canada; Dept. Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada. Electronic address:

Recent reports in pathophysiology of neurodegenerative diseases (ND) have linked nuclear lamina degradation/deficits to neuronal cell death. Lamin-B1 damage is specifically involved in this process leading to nuclear envelope invagination and heterochromatin rearrangement. The underlying mechanisms involved in these events are not yet defined. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.02.010DOI Listing
February 2019
4 Reads

The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses.

Aging Cell 2019 Feb 15:e12916. Epub 2019 Feb 15.

Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Naked mole-rats (NMRs) are mouse-sized mammals that exhibit an exceptionally long lifespan (>30 vs. <4 years for mice), and resist aging-related pathologies such as cardiovascular and pulmonary diseases, cancer, and neurodegeneration. However, the mechanisms underlying this exceptional longevity and disease resistance remain poorly understood. Read More

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http://dx.doi.org/10.1111/acel.12916DOI Listing
February 2019
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Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee's Social Immune System.

Genome Biol Evol 2019 Feb 15. Epub 2019 Feb 15.

Department of Biology, York University, Toronto, Ontario, Canada.

Social organisms combat pathogens through individual innate immune responses or through social immunity -allobehaviours that limit pathogen transmission within groups. While we have a relatively detailed understanding of the genetics and evolution of the innate immunity in animals, we know little about social immunity. Addressing this knowledge gap is crucial for understanding how life-history traits influence immunity, and if trade-offs exist between innate and social immunity. Read More

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http://dx.doi.org/10.1093/gbe/evz018DOI Listing
February 2019

Storytelling: How We Learn.

Authors:
Anne Katz

Oncol Nurs Forum 2019 03;46(2):141-142

CancerCare Manitoba.

The best conference presentations tell a story with an interesting introduction, details in the middle, and a conclusion that leads to new research, questions or answers about practice, and perhaps further research on the topic. So, too, do journal articles, and this publication is dependent on the rigors of quality research to tell stories about our patients and their experiences and make suggestions on how we can effect change. Read More

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http://dx.doi.org/10.1188/19.ONF.141-142DOI Listing

A Review of Clinical Poster Presentations at the Sixth Biennial Pediatric Anesthesia Neurodevelopment Assessment (PANDA) Symposium.

J Neurosurg Anesthesiol 2019 Jan;31(1):166-169

Department of Anesthesiology.

Clinical researchers studying the long-term neurocognitive effects of anesthetic and sedative agents on children continue to struggle with identifying a phenotype for anesthetic neurotoxicity, the window of vulnerability, and the toxicity threshold in terms of concentration and duration. The Sixth Biennial Pediatric Anesthesia Neurodevelopment Assessment (PANDA) symposium at Columbia University included a moderated poster presentation session where 4 investigators presented their latest contributions to the landscape of clinical anesthetic neurotoxicity research. A lack of standardization in the design of clinical studies in terms of age at exposure, duration and type of exposure, and outcome measures assessed were highlighted by all the investigators. Read More

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http://dx.doi.org/10.1097/ANA.0000000000000543DOI Listing
January 2019

The role of sodium glucose cotransporter-2 (SGLT-2) inhibitors in heart failure and chronic kidney disease in type 2 diabetes.

Curr Med Res Opin 2019 Feb 15:1-13. Epub 2019 Feb 15.

e Division of Nephrology , St. Michael's Hospital , Toronto , Ontario , Canada.

Background: Heart failure (HF) and chronic kidney disease (CKD) are responsible for substantial morbidity and mortality in individuals with type 2 diabetes (T2D).

Methods: This review discusses the significance of these comorbidities of T2D and current options for managing them, with a focus on sodium-glucose cotransporter-2 (SGLT-2) inhibitors. Based on a focused literature search of cardiovascular outcomes trials (CVOTs), this review assessed the effects of SGLT-2 inhibitors in individuals with T2D with or without established cardiovascular disease (CVD). Read More

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http://dx.doi.org/10.1080/03007995.2019.1576479DOI Listing
February 2019
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Hepatitis B Virus Infection of Normal Hepatic Stem/Progenitor Cells.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):34-42. Epub 2018 Feb 16.

Section of Hepatology, Department of Medicine, University of Manitoba, Winnipeg, Canada.

Background/aims: Whether the hepatitis B virus (HBV) infects normal hepatic stem/progenitor cells (NSCs) and if so, whether such infections play a role in the pathogenesis of HBV-induced chronic liver disease (CLD) and/or hepatocellular carcinoma (HCC) remains to be determined. The objectives of this study were to determine whether HBV infects NSCs and whether such infections alter NSC activity in a manner likely to contribute to the development of CLD and/or HCC.

Methods: Liver biopsies from five hepatitis B surface antigen (HBsAg) positive patients were co-stained for HBcAg and HBx and the stem cell markers EpCAM, Oct-4 and Nanog. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363946PMC
February 2018
1 Read