27,145 results match your criteria Manitoba RN Journal [Journal]


Investigating the Association Between Baseline Characteristics (HbA1c and Body Mass Index) and Clinical Outcomes of Fast-Acting Insulin Aspart in People with Diabetes: A Post Hoc Analysis.

Diabetes Ther 2018 Dec 13. Epub 2018 Dec 13.

Clinical and Experimental Endocrinology, University Hospital Leuven, Catholic University of Leuven, Leuven, Belgium.

Introduction: The aim of this study was to investigate the association between baseline characteristics [HbA1c and body mass index (BMI)] and the effect of mealtime fast-acting insulin aspart (faster aspart) relative to insulin aspart (IAsp) or basal-only insulin therapy on several efficacy and safety outcomes in people with diabetes.

Methods: Post hoc analysis of three randomised phase 3a trials in people with type 1 diabetes (T1D; onset 1) and type 2 diabetes (T2D; onset 2 and 3). Participants (N = 1686) were stratified according to baseline BMI (< 25 kg/m, 25-< 30 kg/m, ≥ 30 kg/m) or HbA1c (≤ 58 mmol/mol, > 58-< 64 mmol/mol, ≥ 64 mmol/mol; ≤ 7. Read More

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December 2018

Public housing and healthcare use: an investigation using linked administrative data.

Can J Public Health 2018 Dec 13. Epub 2018 Dec 13.

Department of Community Health Sciences, University of Manitoba, S113-750 Bannatyne Ave, Winnipeg, Manitoba, R3E 0W3, Canada.

Objective: This study investigated whether a move to public housing affects people's use of healthcare services.

Method: Using administrative data from Manitoba, the number of hospitalizations, general practitioner (GP), specialist and emergency department (ED) visits, and prescription drugs dispensed in the years before and after the housing move-in date (2012/2013) were measured for a public housing and matched cohort. Generalized linear models with generalized estimating equations tested for differences between the cohorts in utilization trends. Read More

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December 2018

Dynamics of Biofilm Formation by Salmonella Typhimurium and Beef Processing Plant Bacteria in Mono- and Dual-Species Cultures.

Microb Ecol 2018 Dec 13. Epub 2018 Dec 13.

Agriculture and Agri-Food Canada Lacombe Research and Development Centre, 6000 C & E Trail, Lacombe, Alberta, T4L 1W1, Canada.

This study aimed to determine the impact of bacteria from a beef plant conveyor belt on the biofilm formation of Salmonella in dual-species cultures. Beef plant isolates (50) including 18 Gram-negative aerobes (GNA), 8 Gram-positive aerobes (GPA), 5 lactic acid bacteria (LAB), 9 Enterobacteriaceae (EB), and 10 generic Escherichia coli (GEC) were included for developing biofilms in mono- and co-culture with S. Typhimurium at 15 °C for 6 days. Read More

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December 2018

Genetic drivers of cerebral blood flow dysfunction in TBI: a speculative synthesis.

Nat Rev Neurol 2018 Dec 13. Epub 2018 Dec 13.

Division of Anaesthesia, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

Cerebral autoregulatory dysfunction after traumatic brain injury (TBI) is strongly linked to poor global outcome in patients at 6 months after injury. However, our understanding of the drivers of this dysfunction is limited. Genetic variation among individuals within a population gives rise to single-nucleotide polymorphisms (SNPs) that have the potential to influence a given patient's cerebrovascular response to an injury. Read More

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December 2018
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Quantitative Model for Ion Transport and Cytoplasm Conductivity of Chinese Hamster Ovary Cells.

Sci Rep 2018 Dec 13;8(1):17818. Epub 2018 Dec 13.

Department of Electrical and Computer Engineering, University of Manitoba, Winnipeg, R3T 2N2, Canada.

In mammalian cells cytoplasm ion concentrations and hence cytoplasm conductivity is an important indicator of their physiological state. Changes in the cytoplasm conductivity has been associated with physiological changes such as progression of cancer and apoptosis. In this work, a model that predicts the effects of physiological changes in ion transport on the cytoplasm conductivity of Chinese hamster ovary (CHO) cells is demonstrated. Read More

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December 2018

New Cancer Drug Approvals From the Perspective of a Universal Healthcare System: Analyses of the Pan-Canadian Oncology Drug Review Recommendations.

J Natl Compr Canc Netw 2018 Dec;16(12):1460-1466

CancerCare Manitoba, and University of Manitoba, Winnipeg, Manitoba, Canada.

FDA approvals do not consider cost, but they set the tone for regulatory approvals worldwide, including in countries with universal healthcare where cost-effectiveness, utility, and adoption feasibility are considered rigorously. Data from the pan-Canadian Oncology Drug Review (pCODR), a national drug review system that makes evidence-based funding recommendations to Canada's provinces and territories, were collected. Our objectives were to assess (1) temporal trends in cost and efficacy of drugs reviewed, (2) correlations among magnitude of benefits, cost, and pCODR decisions, and (3) predictors of approvals. Read More

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December 2018

Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes.

Mol Metab 2018 Nov 28. Epub 2018 Nov 28.

Division of Neurodegenerative Disorders, St Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada; Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada. Electronic address:

Objective: Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of diabetic patients leading to significant morbidity. There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochondrial function in dorsal root ganglia (DRG) of animal models of type 1 and type 2 diabetes. We hypothesized that sub-optimal insulin-like growth factor 1 (IGF-1) signaling in diabetes drives loss of AMPK activity and mitochondrial function, both contributing to development of DSPN. Read More

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November 2018
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A comparative study of the gut microbiota in immune-mediated inflammatory diseases-does a common dysbiosis exist?

Microbiome 2018 Dec 13;6(1):221. Epub 2018 Dec 13.

University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada.

Background: Immune-mediated inflammatory disease (IMID) represents a substantial health concern. It is widely recognized that IMID patients are at a higher risk for developing secondary inflammation-related conditions. While an ambiguous etiology is common to all IMIDs, in recent years, considerable knowledge has emerged regarding the plausible role of the gut microbiome in IMIDs. Read More

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December 2018

RVFV Infection in Goats by Different Routes of Inoculation.

Viruses 2018 Dec 12;10(12). Epub 2018 Dec 12.

Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada.

Rift Valley fever virus (RVFV) is a zoonotic arbovirus of the Phenuiviridae family. Infection causes abortions in pregnant animals, high mortality in neonate animals, and mild to severe symptoms in both people and animals. There is currently an ongoing effort to produce safe and efficacious veterinary vaccines against RVFV in livestock to protect against both primary infection in animals and zoonotic infections in people. Read More

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December 2018

Molecular hydrogen (H2): Potential in mitigating oxidative stress-induced cardiotoxicity.

Can J Physiol Pharmacol 2018 Dec 13. Epub 2018 Dec 13.

Slovak Academy of Sciences, Centre of Experimental Medicine, Institute for Heart Research, Bratislava, Slovakia ;

Uncontrolled production of oxygen and nitrogen radicals results in oxidative (OS) and nitrosative (NS) stresses that impair cellular functions and have been regarded as causative common denominators of many pathological processes. In this review, we report on the beneficial effects of molecular hydrogen (H2) in scavenging radicals in an artificial system of ●OH formation. As a proof of principle, we also demonstrate that in rat hearts in vivo, administration of H2 led to a significant increase in SOD as well as pAKT, a cell survival signaling molecule. Read More

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December 2018

Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections.

Clin Microbiol Rev 2019 Jan 12;32(1). Epub 2018 Dec 12.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada

SUMMARYRespiratory viral infections are associated with a wide range of acute syndromes and infectious disease processes in children and adults worldwide. Many viruses are implicated in these infections, and these viruses are spread largely via respiratory means between humans but also occasionally from animals to humans. This article is an American Society for Microbiology (ASM)-sponsored Practical Guidance for Clinical Microbiology (PGCM) document identifying best practices for diagnosis and characterization of viruses that cause acute respiratory infections and replaces the most recent prior version of the ASM-sponsored Cumitech 21 document, , published in 1986. Read More

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January 2019

Equine-origin immunoglobulin fragments protects nonhuman primates from Ebola virus disease.

J Virol 2018 Dec 12. Epub 2018 Dec 12.

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

Ebola virus (EBOV) infections result in aggressive hemorrhagic fever in humans with fatality rates reaching 90%, with no licensed, specific therapeutics to treat ill patients. Advances over the past 5 years have firmly established monoclonal antibody (mAb)-based products as the most promising therapeutics for treating EBOV infections, but production is costly, quantities are limited, and thus mAbs are not the best candidates for mass use in the case of an epidemic. To address this need, we generated EBOV-specific polyclonal immunoglobulin fragments F(ab') from horses hyperimmunized with an EBOV vaccine. Read More

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December 2018

Il faut des spécialistes de l’exercice dans nos équipes de soins de santé.

Can Fam Physician 2018 Dec;64(12):889-891

Professeur agrégé au Département de médecine familiale de l'Université du Manitoba, et directeur, Certification et Examens, au Collège des médecins de famille du Canada.

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December 2018

Exercise specialists should be members of our health care team.

Can Fam Physician 2018 Dec;64(12):879-880

Associate Professor in the Department of Family Medicine at the University of Manitoba and Director of Certification and Examinations for the College of Family Physicians of Canada.

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December 2018

: An emerging tick-borne disease of importance in Canada.

IDCases 2018 28;14:e00472. Epub 2018 Nov 28.

Rady Faculty of Health Sciences, Max Rady College of Medicine, Department of Internal Medicine, Section of Medical Oncology and Hematology, University of Manitoba, Winnipeg, MB, Canada.

Human Granulocytic Anaplasmosis (HGA) is an infection caused by the intracellular bacterium . As a tick-borne disease, the public health impact of HGA continues to increase with range expansion of the disease vector. The clinical presentation of HGA is often a non-specific febrile illness. Read More

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November 2018

"Still learning and evolving in our approaches": patient and stakeholder engagement among Canadian community-based primary health care researchers.

Res Involv Engagem 2018 3;4:47. Epub 2018 Dec 3.

1C.T. Lamont Primary Health Care Research Centre, Bruyère Research Institute, Ottawa, ON Canada.

Plain English Summary: Increasingly, health researchers are conducting their research in partnership with non-researchers such as patients and caregivers, advocacy groups, clinicians, and policymakers. The idea behind this partnership is to make research more relevant and appropriate. However, so far there is not much evidence about how this partnership or engagement actually affects research. Read More

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December 2018

Older Men's Definitions of Frailty - The Manitoba Follow-up Study.

Can J Aging 2018 Dec 7:1-8. Epub 2018 Dec 7.

Centre on Aging,University of Manitoba.

ABSTRACTBackground: There is little empirical research into lay definitions of frailty.

Objectives: (1) To explore the definitions of frailty among older men, and (2) to explore if these definitions match commonly used clinical definitions of frailty.

Methods: Analysis of open-ended questions to survey data from a prospective cohort study of older airmen. Read More

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December 2018

Using a Flexible Diary Method Rigorously and Sensitively With Family Carers.

Qual Health Res 2018 Dec 6:1049732318816081. Epub 2018 Dec 6.

3 Carleton University, Ottawa, Ontario, Canada.

Health and social science researchers are increasingly interested in the range of new possibilities and benefits associated with diary methods, particularly using digital devices. In this article, we explore how a flexible diary method, which enables participants to choose the device (i.e. Read More

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December 2018

Bioprosthetic aortic valve replacement: A high standard of comparison for transcatheter aortic valve implantation.

J Thorac Cardiovasc Surg 2018 Nov 8. Epub 2018 Nov 8.

Department of Surgery, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; Cardiac Sciences Program, St Boniface Hospital, Winnipeg, Manitoba, Canada. Electronic address:

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November 2018

Extremists on the Left and Right Use Angry, Negative Language.

Pers Soc Psychol Bull 2018 Dec 11:146167218809705. Epub 2018 Dec 11.

3 The University of Illinois at Chicago, USA.

We propose that political extremists use more negative language than moderates. Previous research found that conservatives report feeling happier than liberals and yet liberals "display greater happiness" in their language than do conservatives. However, some of the previous studies relied on questionable measures of political orientation and affective language, and no studies have examined whether political orientation and affective language are nonlinearly related. Read More

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December 2018

The 3D Cancer Nucleus.

Authors:
Sabine Mai

Genes Chromosomes Cancer 2018 Dec 9. Epub 2018 Dec 9.

Cell Biology, Research Institute for Oncology and Hematology, CancerCare Manitoba, The University of Manitoba, Winnipeg, Canada.

Research into the three-dimensional (3D) organization of the cancer cell genome started over 100 years ago. We follow an exciting avenue of research in this field, from Hansemann's early observations of aberrant mitoses and nuclei in cancer cells in the late 19 century to Boveri's theory of the cancer cell in the early 20 century, to current views of nuclear organization and its changes in cancer. Molecular and imaging methods go hand in hand with providing us with a better understanding of the spatial nature of the cancer cell genome. Read More

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December 2018
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A Comparison of U.S. and Canadian Osteoporosis Screening and Treatment Strategies in Postmenopausal Women.

J Bone Miner Res 2018 Dec 7. Epub 2018 Dec 7.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.

The optimal approach to osteoporosis screening and treatment in postmenopausal women is unclear. We compared 1) the United States Preventive Services Task Force (USPSTF) and Osteoporosis Canada osteoporosis screening strategies; and 2) the National Osteoporosis Foundation (NOF) and Canadian treatment strategies. We used data from the prospective Women's Health Initiative Observational Study and Clinical Trials of women aged 50-79 years at baseline (n = 117,707 followed for self-reported fractures; n = 8,134 in bone mineral density [BMD] subset). Read More

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December 2018

Association of Informal Caregiver Distress with Health Outcomes of Community-Dwelling Dementia Care Recipients: A Systematic Review.

J Am Geriatr Soc 2018 Dec 10. Epub 2018 Dec 10.

Division of Geriatric Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Background: Most dementia care occurs in the community with support from informal caregivers who are often distressed. Dementia caregiver distress is known to be hazardous to the caregiver's health, but the impact on the dementia care recipient is not well known.

Methods: We searched the Medline, Embase, PsycINFO, CINAHL, and Cochrane databases from inception until June 2017 for studies investigating the association of informal caregiver distress with health outcomes of community-dwelling dementia care recipients. Read More

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December 2018

CRAX: A simple cardiovascular risk assessment tool to predict risk of acute myocardial infarction or death.

J Nucl Cardiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Nuclear Medicine, University of Manitoba, 820 Sherbrook Street GC321, Winnipeg, MB, R3A 1R9, Canada.

Background: Determining the risk of cardiovascular events is essential to optimize patient management.

Methods And Results: 5842 individuals underwent SPECT myocardial perfusion imaging (MPI) with 4.4 ± 1. Read More

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December 2018

Whole-Genome Sequences of Propionibacterium australiense NML (LCDC) 98A072 and NML (LCDC) 98A078, Associated with Granulomatous Bovine Lesions.

Microbiol Resour Announc 2018 Nov 21;7(20). Epub 2018 Nov 21.

National Microbiology Laboratory (NML)-CSCHAH Site, Public Health Agency of Canada, Winnipeg, Canada.

Draft genome sequences of Propionibacterium australiense isolates NML 98A072 and NML 98A078, derived from granulomatous lesions of infected bovines, were assembled and studied. Respectively, the genome sizes were 2.99 and 3. Read More

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November 2018

Complete Genome and Plasmid Sequences of 32 Salmonella enterica Strains from 30 Serovars.

Microbiol Resour Announc 2018 Nov 1;7(17). Epub 2018 Nov 1.

National Microbiology Laboratory, Public Health Agency of Canada, Toronto, Ontario, Canada.

We report here 32 completed closed genome sequences of strains representing 30 serotypes of Salmonella. These genome sequences will provide useful references for understanding the genetic variation within Salmonella enterica serotypes, particularly as references to aid in comparative genomics studies, as well as providing information for improving serotyping accuracy. Read More

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November 2018

Role of traditional Chinese medicine in the management of patients with hepatocellular carcinoma.

World J Hepatol 2018 Nov;10(11):799-806

Section of Hepatology, Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 3P4, Canada.

Traditional Chinese Medicines (TCMs) have been employed for centuries in the treatment of patients with hepatocellular carcinoma (HCC). Previous reviews of this topic have focused on certain aspects of TCM treatment rather than an overall assessment of their value and mechanisms of action. Both the Chinese and English medical literatures were reviewed to identify where TCM might be of value in the treatment of HCC and the justification for such treatment. Read More

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November 2018

Pheromone-Induced Odor Associative Fear Learning in Rats.

Sci Rep 2018 Dec 7;8(1):17701. Epub 2018 Dec 7.

Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, A1B 3V6, Canada.

Alarm pheromones alert conspecifics to the presence of danger. Can pheromone communication aid in learning specific cues? Such facilitation has an evident evolutionary advantage. We use two associative learning paradigms to test this hypothesis. Read More

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December 2018
5.078 Impact Factor

Nitrogen handling in the elasmobranch gut: a role for microbial urease.

J Exp Biol 2018 Dec 10. Epub 2018 Dec 10.

Bamfield Marine Sciences Centre, 100 Pachena Road, Bamfield, BC, V0R 1B0, Canada.

Ureotelic elasmobranchs require nitrogen for both protein growth and urea-based osmoregulation, and therefore are probably nitrogen-limited in nature. Mechanisms exist for retaining and/or scavenging nitrogen at gills, kidney, rectal gland, and gut, but as yet, the latter are not well characterized. Intestinal sac preparations of the Pacific spiny dogfish shark () incubated strongly reabsorbed urea from the lumen after feeding, but mucosal fluid ammonia concentrations increased with incubation time. Read More

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December 2018

Prescribing and testing by primary care providers to assess adherence to the Choosing Wisely Canada recommendations: a retrospective cohort study.

CMAJ Open 2018 Oct-Dec;6(4):E603-E610. Epub 2018 Dec 10.

Departments of Family Medicine (Singer, Kosowan, Katz, Jolin-Dahel, Appel) and Community Health Sciences (Katz, Lix), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba; Manitoba Primary Care Research Network (Singer); Manitoba Centre for Health Policy (Katz), Winnipeg, Man.; Centre Medical Seine (Jolin-Dahel), Ste. Anne, Man.; Seven Oaks Hospital (Appel), Winnipeg, Man.

Background: Choosing Wisely Canada is an initiative to reduce overprescribing and overtesting. This study assessed adherence to 4 Choosing Wisely Canada recommendations for interventions commonly performed in primary care: (a) antibiotic prescriptions for infections that are probably viral in origin, (b) routine vitamin D tests in low-risk adults, (c) annual screening blood tests and (d) prescriptions of antipsychotic medication to treat symptoms of dementia.

Methods: We conducted a retrospective cohort study of data from the electronic medical records of patients who had an encounter between 2014 and 2016 with a participating Manitoba Primary Care Research Network primary care provider in Manitoba, Canada. Read More

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December 2018

Recommendations on screening for breast cancer in women aged 40-74 years who are not at increased risk for breast cancer.

CMAJ 2018 Dec;190(49):E1441-E1451

Department of Medicine (Klarenbach), University of Alberta, Edmonton, Alta.; Department of Family Medicine (Lewin), University of Ottawa, Ottawa, Ont.; Departments of Internal Medicine and Community Health Sciences (Singh), University of Manitoba, Winnipeg, Man.; Department of Family Medicine (Thériault), McGill University, Montréal, Que.; Department of Medicine (Tonelli), University of Calgary, Calgary, Alta.; Public Health Agency of Canada (Sims-Jones, Courage, Doull, Jaramillo Garcia), Ottawa, Ont.; Department of Psychiatry (Thombs), McGill University, Montréal, Que.

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December 2018

Changes in thyroid function of nestling tree swallows (Tachycineta bicolor) in relation to polycyclic aromatic compounds and other environmental stressors in the Athabasca Oil Sands Region.

Environ Res 2018 Nov 22;169:464-475. Epub 2018 Nov 22.

Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta, Canada T2N 4Z6.

In the Canadian Athabasca Oil Sands Region (AOSR), nestling tree swallows (Tachycineta bicolor) raised near mining-related activities accumulated greater concentrations of polycyclic aromatic compounds (PACs) that contributed to their poorer condition, growth, and reproductive success. Here, we report changes in thyroid function of the same 14 day old (do) nestlings (N ≤ 68) at these mining-related sites (OS1, OS2) compared to reference nestlings (REF1), and in relation to multiple environmental stressors that influence avian thyroid function. Thyroid function was compromised for OS1 nestlings but generally comparable between OS2 and REF1 chicks. Read More

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November 2018

In vitro differentiation of tracheary elements is induced by suppression of Arabidopsis phytoglobins.

Plant Physiol Biochem 2018 Nov 29;135:141-148. Epub 2018 Nov 29.

Department of Plant Science, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada. Electronic address:

Differentiation of tracheary elements (TEs) in vitro was affected by the expression level of the Arabidopsis thaliana Col-0 phytoglobins (Pgbs). Over-expression of Pgb1 or Pgb2 (35S:Pgb1 or 35S:Pgb2 lines) reduced the differentiation process while suppression of either Pgb (Pgb1-RNAi or pgb2 lines) enhanced the production of TEs. The inductive effect of Pgb suppression on TE differentiation was linked to the reduced expression of the transcription factor MYC2. Read More

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November 2018

Interventions to help people understand community immunity: A systematic review.

Vaccine 2018 Dec 6. Epub 2018 Dec 6.

Department of Family and Emergency Medicine, Laval University, 1050 avenue de la Médecine, Pavillon Ferdinand-Vandry, Quebec City, QC G1V 0A6, Canada. Electronic address:

Background: Herd immunity, or community immunity, occurs when susceptible people in a population are indirectly protected from infection thanks to the pervasiveness of immunity within the population. In this study, we aimed to systematically review interventions designed to communicate what community immunity is and how community immunity works to members of the general public.

Methods: We searched PubMed, EMBASE, CINAHL, the Cochrane Central Register of Controlled Trials and Web of Science for peer-reviewed articles describing interventions with or without evaluations. Read More

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December 2018

Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells.

J Pharmacol Sci 2018 Nov 25. Epub 2018 Nov 25.

Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Integrative & Optimized Medicine Research Center, China-USA Institute for Acupuncture and Rehabilitation, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Background: Neuroinflammation plays a major role in the development of ischemic stroke, and regulation of the proinflammatory TLR4 signaling pathway in microglia stands to be a promising therapeutic strategy for stroke intervention. Recently, the homeostasis of mitochondrial dynamics has also been raised as a vital component in maintaining neuronal health, but its relevance in microglia hasn't been investigated. Schaftoside, a natural flavonoid compound and a promising treatment for inflammation, has demonstrated potency against LPS-induced lung inflammation in mice; however, its action on TLR4-induced neuroinflammation and mitochondrial dynamics in microglia is still unknown. Read More

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November 2018

Clinical faculty development initiative: Providing student feedback.

J Prof Nurs 2018 Nov - Dec;34(6):463-469. Epub 2018 Apr 3.

College of Nursing, Rady Faculty of Health Sciences, University of Manitoba, Canada.

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Canada's global health role - Authors' reply.

Lancet 2018 Dec;392(10162):2350-2351

Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Medicine and School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.

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December 2018

The Potential Dangers of Recruitment Maneuvers During One Lung Ventilation Surgery.

J Surg Res 2019 Feb 11;234:178-183. Epub 2018 Oct 11.

Division of Thoracic Surgery, Western University, London, Ontario, Canada.

Background: Existing evidence regarding lung-protective ventilation (LPV) during one-lung ventilation (OLV) focuses on surrogate outcomes. Our objective was to assess whether an LPV protocol during OLV surgery is associated with reduced respiratory complications.

Materials And Methods: This was a matched control retrospective cohort study of patients undergoing pulmonary resection at a tertiary Canadian hospital. Read More

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February 2019
2 Reads

Omega-3 supplementation with resistance training does not improve body composition or lower biomarkers of inflammation more so than resistance training alone in older men.

Nutr Res 2018 Dec 19;60:87-95. Epub 2018 Sep 19.

Department of Human Nutritional Sciences, Faculty of Agricultural and Food Sciences, University of Manitoba, W565 Duff Roblin Bldg, Winnipeg, Manitoba, Canada.

The purpose of this study was to evaluate the effectiveness of 3.0 g/d of omega-3 fatty acid (eicosapentaenoic acid and docosahexaenoic acid) supplementation combined with progressive resistance training to improve body composition and lower inflammatory cytokines in older men when compared to placebo and resistance training. We hypothesized that completing a 12-week omega-3 supplementation period along with whole body resistance exercise (3 times/wk) would result in a significantly greater improvement in lean tissue mass as well as a significant decrease in interleukin-6 and tumor necrosis factor-α when compared to placebo. Read More

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December 2018

Multimodality Imaging of a Giant Right Coronary Artery Aneurysm.

Can J Cardiol 2018 Dec 24;34(12):1688.e5-1688.e7. Epub 2018 Aug 24.

Section of Cardiology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

We describe a case of a 54-year-old woman who had a right cardiac mass found on coronary angiography. Echocardiography, computed tomography, and cardiac magnetic resonance imaging characterized it as a thrombosed giant right coronary artery aneurysm. This was confirmed on pathology. Read More

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December 2018

Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Update 2018.

Can J Cardiol 2018 Dec;34(12):1553-1563

Research Institute of the McGill University Health Centre, Royal Victoria Hospital, Montréal, Quebec, Canada; Department of Medicine, McGill University, Montréal, Quebec, Canada.

Familial hypercholesterolemia (FH) is the most common monogenic disorder causing premature atherosclerotic cardiovascular disease. It affects 1 in 250 individuals worldwide, and of the approximately 145,000 Canadians estimated to have FH, most are undiagnosed. Herein, we provide an update of the 2014 Canadian Cardiovascular Society position statement on FH addressing the need for case identification, prompt recognition, and treatment with statins and ezetimibe, and cascade family screening. Read More

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December 2018
2 Reads

CHIPS-Child: Testing the developmental programming hypothesis in the offspring of the CHIPS trial.

Pregnancy Hypertens 2018 Oct 19;14:15-22. Epub 2018 May 19.

Obstetrics and Gynaecology, Universite de Sherbrooke, Canada. Electronic address:

Objectives: As a follow-up to the CHIPS trial (Control of Hypertension In Pregnancy Study) of 'less tight' (versus 'tight') control of maternal blood pressure in pregnancy, CHIPS-Child investigated potential developmental programming of maternal blood pressure control in pregnancy, by examining measures of postnatal growth rate and hypothalamic-pituitary adrenal (HPA) axis activation.

Methods: CHIPS follow-up was extended to 12 ± 2 months corrected post-gestational age for anthropometry (weight, length, head/waist circumference). For eligible children with consent for a study visit, we collected biological samples (hair/buccal samples) to evaluate HPA axis function (hair cortisol levels) and epigenetic change (DNA methylation analysis of buccal cells). Read More

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October 2018

Interactive effects of dietary fibre and lipid types modulate gastrointestinal flows and apparent digestibility of fatty acids in growing pigs.

Br J Nutr 2018 Dec 11:1-12. Epub 2018 Dec 11.

1Department of Animal Science,University of Manitoba,Winnipeg, MB, Canada R3T 2N2.

A total of eight ileal and caecal cannulated Yorkshire barrows were used to determine the interactions of dietary fibre (DF) and lipid types on apparent digestibility of DM and fatty acids (FA) and FA flows in gastrointestinal segments. Pigs were offered four diets that contained either pectin or cellulose with or without beef tallow or maize oil in two Youden square designs (n 6). Each period lasted 15 d. Read More

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December 2018
1 Read

Innate immune response in the pathogenesis of heart failure in survivors of myocardial infarction.

Am J Physiol Heart Circ Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Physiology and Pathophysiology, Institute of Cardiovascular Sciences, Canada.

Among different cardiovascular disease complications, atherosclerosis-induced myocardial infarction (MI) is the major contributor of heart failure (HF) and loss of life. This review presents short and long-term features of post-MI in human hearts and animal models. It is known that the heart does not regenerate, thus loss of cardiac cells after an MI event is permanent. Read More

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December 2018

Global Tudor-SN transgenic mice are protected from obesity-induced hepatic steatosis and insulin resistance.

FASEB J 2018 Dec 6:fj201801253RR. Epub 2018 Dec 6.

Key Laboratory of Immune Microenvironment and Disease, Ministry of Education, Tianjin Medical University, Tianjin, China.

In the current study, we explored the impact of Tudor-staphylococcal nuclease (SN) on obesity induced by a high-fat diet (HFD) in mice, because the functional involvement of Tudor-SN in lipid metabolism in vivo is unknown. HFD-transgenic (Tg) mice exhibited reductions in hepatic steatosis and systemic insulin resistance. There was no difference in hepatic lipid accumulation between chow-fed wild-type (WT) and chow-fed Tg mice; consistently, no difference in activation of the lipogenic pathway was detected. Read More

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December 2018
2 Reads

DHA supplementation during prenatal ethanol exposure alters the expression of fetal rat liver genes involved in oxidative stress regulation.

Appl Physiol Nutr Metab 2018 Dec 6. Epub 2018 Dec 6.

University of Manitoba, Food and Human Nutritional Sciences, Winnipeg, Manitoba, Canada.

Prenatal ethanol (EtOH) exposure is known to induce adverse effects on fetal brain development. Docosahexaenoic acid (DHA) has been shown to alleviate these effects by upregulating antioxidant mechanisms in the brain. The liver is the first organ to receive enriched blood after placental transport; therefore, it could be negatively affected by EtOH, but no studies have assessed the effects of DHA on fetal liver. Read More

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December 2018
1 Read

Cerebral oximetry monitoring. To guide physiology, avert catastrophe or both?

Authors:
Hilary P Grocott

Eur J Anaesthesiol 2019 Jan;36(1):82-83

From the Department of Anesthesiology, Perioperative & Pain Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

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January 2019