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J Dent (Shiraz) 2020 Jun;21(2):153-157

Postgraduate student, Dept. of Endodontics, Faculty of Dentistry, Tehran Medical Science Islamic Azad University, Tehran, Iran.

Calcifying odontogenic cyst is an uncommon odontogenic lesion that represents less than 2% of all odontogenic cysts and tumors. It usually occurs in incisor and canine areas during the second to fourth decades of life. It can be associated with other lesions like odontoma, ameloblastic fibroma, ameloblastoma, adenomatoid odontogenic tumors, odontoameloblastoma, and odontogenic myxoma. Read More

J Am Vet Med Assoc 2020 Jun;256(12):1359-1367

Objective: To characterize clinical, radiographic, and histologic features of canine furcation cysts (CFCs) in dogs and to propose possible mechanisms of CFC development.

Animals: 20 client-owned dogs with CFCs biopsied between January 1, 2013, and December 31, 2017.

Procedures: Medical records of the Center for Comparative Oral and Maxillofacial Pathology at the University of Wisconsin-Madison were retrospectively searched to identify records of dogs that had surgical biopsy specimens of mandibular or maxillary cavitary lesions diagnosed as odontogenic cysts and that met additional inclusion criteria. Read More

Ned Tijdschr Tandheelkd 2020 Feb;127(2):97-101

A 67-year-old man presented with a swelling on the right side of the mandible. Histopathological investigation of a biopsy revealed a peripheral dentogenic ghost cell tumour. Treatment consisted of thorough excochleation of the abnormality and 2 years after treatment, the patient was free of recurrence. Read More

Curr Med Imaging 2020 Feb 5. Epub 2020 Feb 5.

Istanbul University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology, Istanbul, Turkey.

Background: Impacted teeth are commonly asymptomatic and not associated with any pathologic lesions for years. Any change in the size of the follicle associated with impacted teeth may result in odontogenic cysts or tumors. CBCT plays an important role in determining the radiographic features of a lesion and therefore, is very helpful for accurate diagnosis and treatment planning. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):35-42

Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To investigate the clinicopathologic features and prognostic factors in odontogenic keratocyst (OKC), and to provide new reference for clinic treatment and management of these patients.

Methods: Clinicopathological data of 844 cases initially diagnosed as or associated with OKC at Department of Oral Pathology, Peking University Hospital of Stomatology from 2000 to 2018 were collected. The cases were divided into 4 groups: sporadic OKCs (intraosseous, cystic lesion irrelevant to nevoid basal cell carcinoma syndrome), syndromic OKCs, solid OKCs and peripheral OKCs. Read More

Int J Surg Case Rep 2020 27;67:239-244. Epub 2020 Jan 27.

School of Dentistry, Federal University of Pará (UFPA), Belém, PA, Brazil. Electronic address:

Introduction: Odontogenic pathological lesions can generally be divided into cysts and tumors. Calcifying odontogenic cyst (COC) is a non-aggressive odontogenic cyst, however, in a few occasions, COC can show excessive growth and destruction. This study describes an uncommon aggressive presentation of a large COC and discusses the treatment strategies used to achieve a favorable result. Read More

Dermatol Online J 2019 Nov 15;25(11). Epub 2019 Nov 15.

Department of Dermatology, Wake Forest Baptist Medical Center, Winston Salem, NC.

Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome, is a rare autosomal dominant disorder that is characterized by multiple basal cell carcinomas developing at a young age, keratocystic odontogenic tumors of the jaw, palmar or plantar pits, calcification of the falx cerebri, and skeletal abnormalities. Nevoid basal cell carcinoma syndrome is caused by mutations in the PTCH1 or SUFU genes. Our patient with Fitzpatrick skin type VI was diagnosed with Gorlin syndrome based on the presentation of multiple major diagnostic characteristics. Read More

Curr Med Imaging Rev 2020 Feb 5. Epub 2020 Feb 5.

Istanbul University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology, Istanbul, Turkey.

Background: Impacted teeth are commonly asymptomatic and not associated with any pathologic lesions for years. Any change in the size of the follicle associated with impacted teeth may result in odontogenic cysts or tumors. CBCT plays an important role in determining the radiographic features of a lesion and therefore, is very helpful for accurate diagnosis and treatment planning. Read More

Diagnostics (Basel) 2019 Dec 20;10(1). Epub 2019 Dec 20.

Laboratory of Oral and Maxillofacial Pathology, Unit of Oral Medicine & Oral Maxillofacial Pathology, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, CUMD, 1206 Geneva, Switzerland.

The objective of the study is to present the clinico-pathological features of cystic and classic adenomatoid odontogenic tumors (AOTs) in order to identify the differences between the two variants of AOT.

Materials And Method: The study sample comprised of 41 AOTs, which were categorized into cystic and classic AOTs. Cystic AOTs are diagnosed as such when macroscopic and microscopic evidence of a cyst is present together with histopathological criteria of AOT (WHO-2017). Read More

Indian J Dent Res 2019 Sep-Oct;30(5):751-754

Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: Dentigerous cyst (DC) is the most common type of developmental odontogenic cysts which apparently develops via accumulation of fluid between the reduced enamel epithelium and crown of the tooth. The aim of this study is to analyze the frequency of DC in Iranian population.

Materials And Methods: The files of oral pathology, Shahid Beheshti University of Medical Sciences, served as the source of the materials from 1992 to 2012 for this study. Read More

Dent Clin North Am 2020 01 18;64(1):121-138. Epub 2019 Oct 18.

474 Golf Valley Court, Douglasville, GA 30135, USA.

Odontogenic tumors are a group of neoplastic growths that originate from the tissues responsible for tooth formation and the periodontal apparatus of the jaw. Odontogenic tumors usually present as radiolucent defect, which makes diagnosis somewhat confusing while differentiating them from cysts. Although cystic lesions are surrounded by sclerotic borders, few odontogenic tumors share similar features. Read More

Dent Med Probl 2019 Oct-Dec;56(4):433-436

Division of Dental Surgery, Department of Craniomaxillofacial Surgery and Oral Surgery, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Bytom, Poland.

Based on a literature review, we analyzed the World Health Organization (WHO) classification and the treatment algorithm for the odontogenic keratocyst (OKC), formerly referred to as keratocystic odontogenic tumor (KCOT). The KCOT reclassification from benign odontogenic tumors to odontogenic developmental cysts resulted from the emergence of new evidence regarding their morphogenesis and biological behavior. The authors of the most recent 2017 classification do not provide specific guidelines for OKC. Read More

J Dent (Shiraz) 2019 Sep;20(3):145-151

Dept. of Oral and Maxillofacial Surgery, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Various treatment modalities have been reported for keratocystic odontogenic tumors (KOT), with different recurrence rates. Marsupialization and decompression are two different conservative surgical techniques for the treatment of KOTs. This study aimed at comparing the recurrence rate between marsupialization and decompression in the treatment of KOTs with or without adjunctive treatments. Read More

J Biol Regul Homeost Agents 2019 May-Jun;33(3 Suppl. 1):169-172

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

Mandibular third molars (MM3s) are responsible for pericoronitis, primary and/or secondary crowding of the dentition, odontogenic tumors and cysts, periodontal defects associated with the posterior part of mandibular second molars. Tooth extraction is indicated for prophylactic and therapeutic purpose in patients with problems caused by impacted teeth. Common postoperative complications associated with third molar extraction are alveolitis (0. Read More

Pan Afr Med J 2018 27;31:208. Epub 2018 Nov 27.

Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, University of the Western Cape and Tygerberg Hospital, Cape Town, South Africa.

Introduction: Ameloblastic carcinoma is a rare malignant odontogenic neoplasm that exhibits histological features of ameloblastoma in combination with cytological atypia. It may arise de novo or secondarily through malignant de-differentiation of pre-existing ameloblastoma or odontogenic cyst. Secondary ameloblastic carcinomas often results from repeated surgical intervention, which is a mainstay of odontogenic tumor management in resource limited settings. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Aug;54(8):546-552

Department of Pathology, School and Hospital of Stomatology, Jilin University, Changchun 130021, China.

To investigate the incidence and constituent ratio of odontogenic tumors or odontogenic cysts in School and Hospital of Stomatology, Jilin University and to provide the reference for the clinical treatment. According to the WHO 2017 histological classification criteria, the pathological data of 4181 patients diagnosed as odontogenic tumors or odontogenic cysts in the Department of Pathology, Jilin University Stomatological Hospital from January 1961 to December 2017 were collected. Statistical analysis of the pathological types, gender, age and location of various tumors and cysts was conducted. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Oct 6;128(4):424-430. Epub 2019 Jun 6.

Professor, Department of Oral and Maxillofacial Radiology, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.

Objective: The aim of this study was to investigate whether a deep learning object detection technique can automatically detect and classify radiolucent lesions in the mandible on panoramic radiographs.

Study Design: Panoramic radiographs of patients with mandibular radiolucent lesions of 10 mm or greater, including ameloblastomas, odontogenic keratocysts, dentigerous cysts, radicular cysts, and simple bone cysts, were included. Lesion labels, including region of interest coordinates, were created in text format. Read More

Imaging Sci Dent 2019 Jun 24;49(2):87-95. Epub 2019 Jun 24.

School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: The aim of this study was to review the common conditions associated with mandibular canal widening.

Materials And Methods: General search engines and specialized databases including Google Scholar, PubMed, PubMed Central, Science Direct, and Scopus were used to find relevant studies by using the following keywords: "mandibular canal," "alveolar canal," "inferior alveolar nerve canal," "inferior dental canal," "inferior mandibular canal," "widening," "enlargement," "distension," "expansion," and "dilation."

Results: In total, 130 articles were found, of which 80 were broadly relevant to the topic. Read More

Imaging Sci Dent 2019 Jun 24;49(2):79-86. Epub 2019 Jun 24.

Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: This study reviewed the common conditions associated with displacement of inferior alveolar nerve canal.

Materials And Methods: General search engines and specialized databases including Google Scholar, Pub Med, Pub Med Central, Science Direct, and Scopus were used to find relevant studies by using keywords such as "mandibular canal", "alveolar canal", "inferior alveolar nerve canal", "inferior dental canal", "inferior mandibular canal" and "displacement".

Results: About 120 articles were found, of which approximately 70 were broadly relevant to the topic. Read More

Med Oral Patol Oral Cir Bucal 2019 Jul 1;24(4):e491-e501. Epub 2019 Jul 1.

School, and Hospital of Stomatology, Wuhan University, Wuhan, China, Wuhan 430079, China,

Background: To describe epidemiological features of 565 Chinese patients with odontogenic keratocysts (OKC), to investigate possible prognostic factors related to recurrence, and to analyse features of recurrent OKC (rOKC).

Material And Methods: A retrospective chart review of 565 cases of OKC treated between 2003 and 2015 was undertaken. The probability of recurrence related to prognostic factors including large size, cortical perforation combined with involved teeth in the lumen of the cyst, inflammation, sites of the involved lesion, sex, and daughter cyst variables were analysed. Read More

J Oral Maxillofac Pathol 2019 Jan-Apr;23(1):140-143

Department of Dentistry, S.R.T.R. Government Medical College, Ambajogai, Maharashtra, India.

Clear cells are associated with numerous physiological and pathological conditions. Odontogenic cysts and tumors can arise from physiological clear cells like rests of dental lamina. One such clear cell neoplasm is clear cell odontogenic carcinoma (CCOC) that is associated with aggressive clinical behavior, metastasis and low survival rate. Read More

Ann Diagn Pathol 2019 Jun 24;40:105-135. Epub 2019 Apr 24.

Oral & Maxillofacial Surgery, Commanding Officer Military Dental Centre (Gough Lines), Secunderabad, India. Electronic address:

Introduction: Large Unilocular radiolucent lesions of the jaws often present a dilemma to both, the Oral Pathologist and the Maxillofacial surgeon with regards to their accurate diagnosis as well as their most appropriate treatment modality. A precise identification as to whether the lesion is a cyst or a tumor is imperative before any treatment is instituted. Once the correct diagnosis and likely prognosis are established, a management protocol can be planned which will completely eliminate the lesion, while at the same time, ensure least possible morbidity for the patient, such as pathological jaw fractures, persisting neurological deficits, esthetic deformity, functional debility, recurrence/persistence of the lesion, etc. Read More

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Oral & Maxillofacial Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

Mucoepidermoid carcinoma (MEC) can be rarely found as a primarily intraosseous lesion and mistaken for other intraosseous or odontogenic pathology. A 65-year-old man had a poorly defined radiolucency distal to the left mandibular second molar root. Periapical radiographs demonstrated a minor radiolucency from 2. Read More

Diagn Pathol 2019 Apr 4;14(1):28. Epub 2019 Apr 4.

Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.

Background: Orthokeratinized Odontogenic Cyst (OOC) is a rare, developmental odontogenic cyst which was considered in the past to be a variant of Odontogenic keratocyst (OKC) later renamed as keratocystic odontogenic tumor (KCOT). The treatment of OOC is by enucleation and the prognosis, following enucleation is excellent with a recurrence rate of less than 2%. On the other hand, OKC has a recurrence rate between 8 and 25% after enucleation. Read More

Gan To Kagaku Ryoho 2019 Mar;46(3):558-560

Dept. of Oral and Maxillofacial Surgery, Matsue City Hospital.

Ameloblastoma is a benign odontogenic tumor that rarely undergoes malignant transformation and metastasis but may be locally invasive and recurrent. Fenestration is used to reduce maxillary odontogenic cysts. Here, we report a case ofameloblastoma that developed in the wall of an odontogenic cyst and was treated with fenestration before curative surgery. Read More

Indian J Dent Res 2019 Jan-Feb;30(1):144-148

Department of Oral and Maxillofacial Pathology, Kamineni Institute of Dental Sciences, Nalgonda, Telangana, India.

Calcifying odontogenic cysts (COCs) represent a heterogeneous group of lesions that exhibits a variety of clinical, behavioral, and histological features. COC or Gorlin's cyst is now classified by the World Health Organization as a tumor. Calcifying cystic odontogenic tumor (CCOT) is an uncommon developmental odontogenic lesion that demonstrates histopathologic diversity. Read More

Ann Plast Surg 2019 04;82(4):469-477

Department of Oral Surgery, Truman VA, Columbia, MO.

Odontogenic cysts and tumors are mandibular and maxillary lesions that occur across all patient demographics across age, sex, race, and social economic status, as altered remnants of dental development. They may be incidental findings from routine imaging in any office or found through workup for craniofacial surgery or injury. Many of these patients present with asymptomatic lesions, whereas others may be symptomatic. Read More

Oral Maxillofac Surg 2019 Jun 2;23(2):133-147. Epub 2019 Mar 2.

Department of Oral & Maxillofacial Surgery, Traumatology and Prosthesis, Faculty of Dentistry of the University of São Paulo, Av Prof. Lineu Prestes 2227, Butantã, São Paulo, 05508-000, Brazil.

Purpose: This study was conducted in order to gain insight in the actual ratio of odontogenic keratocysts occurring in the tooth-bearing area as compared to the posterior region of the jaws in order to come up with reliable data to base upon a rational treatment policy.

Methods: We searched MEDLINE, Web of Science, Scopus, and Cochrane databases for studies reporting on the location of mandibular and maxillary odontogenic keratocysts. All records were independently assessed and a meta-analysis was performed. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Apr 14;127(4):282-288. Epub 2018 Dec 14.

Associate Professor, Departments of Surgery and Pediatrics, Division of Oral and Maxillofacial Surgery, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA.

Objective: The aim of this study was to answer the following clinical questions: Among patients treated for odontogenic keratocysts (OKCs), what is the overall 5-year disease-free rate, and what factors are associated with disease recurrence?

Study Design: We implemented a multicenter retrospective cohort study composed of patients presenting for the evaluation and management of previously untreated OKCs. The predictor variables were grouped into demographic, medical, radiographic, and operative categories. The primary outcome variable was time to lesion recurrence. Read More

Head Neck Pathol 2019 Dec 13;13(4):587-596. Epub 2019 Feb 13.

Department of Oral Medicine and Pathology, Department of Dentistry, School of Health Sciences, National and Kapodistrian University of Athens, 2 Thivon Str, 11527, Goudi, Athens, Greece.

The aim of the present study is to report the demographic and clinical characteristics of all jaw cysts diagnosed in a single Oral Pathology Department. 5294 cases of jaw cysts diagnosed during a 38-year period were retrospectively collected and classified according to the latest classification of Head and Neck Tumors of the World Health Organization. The patients' gender and age, as well as the main clinical features of the cysts were retrieved from biopsy report forms. Read More

Cureus 2018 Oct 10;10(10):e3437. Epub 2018 Oct 10.

Otolaryngology, Aga Khan University Hospital, Karachi, PAK.

Introduction Ameloblastoma is a locally destructive tumor with a propensity for recurrence if not entirely excised. Management of ameloblastoma poses a challenge for all involved in the field of head and neck surgery because successful treatment requires not only adequate resection but also a functional and aesthetically acceptable reconstruction of the residual defect. Methods Patients who had histologically proven ameloblastoma between 1991 and 2009 were identified from the database of Aga Khan University Hospital. Read More

Br J Oral Maxillofac Surg 2018 12 3;56(10):979-981. Epub 2018 Dec 3.

Bülent Ecevit University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Zonguldak, Turkey.

Conservative treatment of odontogenic tumours with decompression or marsupialisation is not common, but can be done successfully in those with a cystic pattern. We present a calcifying epithelial odontogenic tumour that was treated by tube decompression and subsequent enucleation. Read More

Cureus 2018 Sep 18;10(9):e3323. Epub 2018 Sep 18.

Oral and Maxillofacial Surgery, Vishnu Dental College, Bhimavaram, IND.

Impacted teeth may not only interfere with function, but also can act as a source of many pathological lesions such as odontogenic cysts and tumors. One of the most prevalent types of odontogenic cysts associated with erupted, developing or impacted tooth is dentigerous cyst. Multiple impacted teeth with dentigerous cysts in both the maxillary and mandibular arches without the association of any syndromes is a very rare occurrence. Read More

Spec Care Dentist 2019 Jan 15;39(1):45-50. Epub 2018 Nov 15.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.

Eosinophilic granuloma is the most common form of Langerhans cell histiocytosis and corresponds with bone lesions characterized by pain, rapid growth, and high tendency of recurrence after inadequate curettage. It is a rare disease that is difficult to diagnose clinically and radiographically because it mimics other odontogenic cysts and tumors. In this report, the reconstruction of an osseous defect with an iliac graft and a modified implant-supported hybrid prosthesis after surgical excision of an eosinophilic granuloma in the mandible of a 27-year-old male patient was described. Read More

Diagn Cytopathol 2018 11 23;46(11):983-984. Epub 2018 Oct 23.

Department of Oncosurgery, Kalinga Hospitals and Research Centre, Bhubaneswar, Odisha, India.

Saudi Dent J 2018 Jan 31;30(1):94-96. Epub 2017 Oct 31.

Department of Oral and Maxillofacial Surgery, Government Dental College, Aurangabad, India.

Adenomatoid odontogenic tumour (AOT) is an uncommon, hamartomatous, benign epitheial lesion of odontogenic origin. The current World Health Organisation (WHO) classification of odontogenic tumors defines AOT as being composed of the odontogenic epithelium in a variety of histoarchitectural patterns, embedded in mature connective tissue stroma, and characterized by slow, but progressive growth. The aim of this paper is to present three rare cases of intraosseous AOTs with varied clinical and radiographic features imposing the fact that AOT should be included in differential diagnosis of routine odontogenic cysts and tumours. Read More

Int J Pediatr Otorhinolaryngol 2018 Sep 30;112:121-125. Epub 2018 Jun 30.

Oncologic Surgery Department, Centre Léon Bérard, Lyon, France. Electronic address:

Keratocystic odontogenic tumors (KCOT) are exceptional in children and adolescents as they usually occur in the third decade. The present study reports the case of a 15 years old girl who was diagnosed with a KCOT that underwent malignant transformation. KCOT diagnostic was based on clinical, radiological, histopathological and immunohistochemical findings. Read More

J Korean Assoc Oral Maxillofac Surg 2018 Jun 26;44(3):107-111. Epub 2018 Jun 26.

Institute of Translational Dental Sciences, Pusan National University, Yangsan, Korea.

Objectives: A keratocystic odontogenic tumor (KOT) is a type of odontogenic tumor that mainly occurs in the posterior mandible. Most KOTs appear as solitary lesions; however, they sometimes occur as multiple cysts. This study analyzed the clinical features of multiple KOTs. Read More

J Clin Exp Dent 2018 Jun 1;10(6):e542-e547. Epub 2018 Jun 1.

DDS, PhD, Professor, Postgraduate Program in Dentistry, School of Dentistry, Universidade de Pernambuco, Camaragibe, PE, Brazil.

Background: To identify the prevalence and clinicopathological profile of calcifying odontogenic cysts (COC) stored at an oral pathology service, and to analyze the immunoexpression of cyclooxygenase 2 (COX-2) and cyclin D1 (CD1) in these cysts.

Material And Methods: After a retrospective analysis (1990-2016) carried out to identify cases of COC, a sample of 12 cases was selected for immunohistochemical analysis of COX-2 and CD1 by the immunoperoxidase technique. Protein expression was evaluated semiquantitatively by attributing a score of 0 to 3 (0 = no staining; 1 = 1-25%; 2 = 26-50%, and 3 = >51% immunopositive cells). Read More

Gerodontology 2018 Dec 1;35(4):325-332. Epub 2018 Jun 1.

Postgraduate Program in Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Norte, Natal, Brazil.

Objective: The aim of this study was to investigate the frequency and some characteristics of odontogenic tumours, odontogenic cysts and non-odontogenic cysts in an elderly population (≥60 years).

Background: Few studies describe the distribution of oral lesions in older people.

Materials And Methods: A retrospective descriptive cross-sectional study was performed. Read More

Dentomaxillofac Radiol 2018 Oct 5;47(7):20170288. Epub 2018 Jun 5.

1 Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP) , Campinas , Brazil.

Objectives:: The purpose of this study was to describe and compare the main imagenological features of mandibular ameloblastomas and odontogenic keratocyst (OKC) using panoramic radiograph (PR) and CT.

Methods:: The sample consisted of nine cases of ameloblastomas and nine cases of OKC. PR and CT images were analyzed according to shape, internal structure, borders, associated unerupted tooth, root resorption, expansion and perforation of cortical bones. Read More

J Oral Pathol Med 2018 Sep 25;47(8):721-730. Epub 2018 May 25.

Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Background: The aim of this study was to integrate the available data published on calcifying odontogenic cyst (COC), dentinogenic ghost cell tumor (DGCT), and ghost cell odontogenic carcinomas (GCOCs) into a comprehensive analysis of their clinicoradiological features, treatment, and recurrence.

Materials And Methods: An electronic search with no publication date restriction was undertaken in October 2017 in the following databases: PubMed, Medline Ovid, Web of Science, and Scopus. Eligibility criteria included publications containing enough clinical, radiological, and histopathological information to confirm a definite diagnosis of these lesions. Read More

Indian J Dent Res 2018 Mar-Apr;29(2):238-243

Department of Oral Pathology and Microbiology, Government Dental College, Kozhikode, Kerala, India.

Ghost cell odontogenic carcinoma (GCOC) is a malignant odontogenic epithelial tumor which is an exceedingly rare, highly aggressive, rapidly growing, and infiltrative tumor forming the malignant counterpart of long-standing benign cystic lesions coming in the spectrum of calcifying odontogenic cysts. To date, only a few cases have been reported in the medical literature. A case of unusual presentation of GCOC is presented and the clinical, histopathological, and immunohistochemical features are discussed along with a literature review. Read More

J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S20-S23

Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Sangli, Maharashtra, India.

Orthokeratinized odontogenic cyst (OOC) is a relatively rare odontogenic cyst, distinct from odontogenic keratocyst (OKC). In the 4 edition of WHO Classification of Head and Neck Tumors (2017), OOC has been included as a separate entity in the category of developmental odontogenic cysts. It presents as a unilocular radiolucent lesion in the posterior mandible and is frequently related to impacted teeth, thus mimicking dentigerous cyst. Read More

Indian J Dent Res 2018 Jan-Feb;29(1):117-122

Department of Pathology, Graduate Program in Dentistry, Positivo University, Rua Professor Pedro Viriato Parigot de Souza, 5300 Campo Comprido, Curitiba, Paraná, Brazil.

Ameloblastoma is an aggressive odontogenic tumor which typically occurs between third and fourth decade of life that often needs resective approach. Immediate reconstruction may show better results. The treatment of multicystic ameloblastoma in the mandible being a rare case that occurred in the late second decade of life, which was surgically removed along with the affected teeth with safety margins, and the region was immediately reconstructed using a vascularized graft, removed from the fibula. Read More

J Craniomaxillofac Surg 2018 Mar 26;46(3):504-510. Epub 2017 Dec 26.

Department of Oral Surgery and Pathology, (Head: Dr. Henrique Pretti), School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:

Purpose: To integrate the available data published on squamous odontogenic tumors (SOT) and squamous odontogenic tumor-like proliferations in odontogenic cysts (SOT-LPOC) into a comprehensive analysis of their clinical/radiologic features.

Materials And Methods: An electronic search was undertaken in January 2017. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm a definite diagnosis. Read More

BMJ Case Rep 2018 Jan 3;2018. Epub 2018 Jan 3.

Unit of Pedodontics and Preventive Dentistry, Oral Health Sciences Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Keratocystic odontogenic tumour (KCOT) is considered one of the most aggressive odontogenic lesions presenting high recurrence rate which varies according to treatment modalities employed for management. The treatment rendered should have a lowest possible risk of recurrence and least morbidity while still eradicating the lesion. Although the radical treatment options like enucleation and en bloc resection are associated with lesser recurrences, these can lead to greater morbidity, especially in children with developing teeth and jaw bones, thus, emphasising need to consider more conservative treatment options like decompression and marsupialisation. Read More

Braz Oral Res 2017 Dec 18;31:e98. Epub 2017 Dec 18.

Universidade de São Paulo - USP, School of Dentistry, Department of Oral & Maxillofacial Surgery, Traumatology and Prosthesis, São Paulo, SP, Brazil.

The odontogenic keratocyst (OKC) is a recurrent cyst that has been recently reclassified from an odontogenic tumor to an odontogenic cyst. The aim of the present study was to investigate its treatment and address issues related to its association with nevoid basal cell carcinoma syndrome (NBCCS). Lesions from the cohort of patients included in the present study consisted of 40 OKCs, of which 27 lesions were treated by enucleation (GE) and 13 underwent decompression (GD). Read More

J Dent (Shiraz) 2017 Dec;18(4):259-264

Undergraduate Student, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Statement Of The Problem: It is necessary for surgeons and practitioners to know about relative incidence and clinicopathologic features of lesions for accurate diagnosis and approach of pathologic lesions. Data are limited about overall incidence of intra-osseous lesions of the jaws in Iranian patients.

Purpose: This study evaluated the clinicopathologic features of intra- osseous lesions of the jaws in an Iranian population, in a 22-year period. Read More

Quant Imaging Med Surg 2017 Oct;7(5):598-604

Jan Swasthya Sahyog, Hospital and Community Health Centre, Ganiyari, Bilaspur, Chhattisgarh, India.

Dentinogenic ghost cell tumors (DGCT) are very rare tumors considered as solid variants of calcifying epithelial odontogenic cysts (CEOC). They are locally invasive neoplasms and their main characteristic features are ameloblastoma like odontogenic epithelial proliferation, an aberrant keratinization in the form of ghost cells and dysplastic dentin. DGCT occur as two forms intraosseous (central) and extra osseous (peripheral), of which more aggressive intraosseous variety requires careful monitoring and aggressive local resection to prevent recurrence. Read More