Search Our Scientific Publications & Authors

J Oral Biosci 2021 May 16. Epub 2021 May 16.

Departmento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional. Mexico City, Mexico. Electronic address:

Objectives: Ameloblastoma is an odontogenic neoplasm of the mandible and maxilla with various histological types and subtypes. It has been reported that some ameloblastomas could arise from dentigerous cyst walls; thus, the development of ameloblastoma from dentigerous cysts may be due to differential protein expression. Our aim was to identify a membrane protein that is differentially expressed in ameloblastomas with respect to dentigerous cysts. Read More

Head Neck Pathol 2021 Apr 21. Epub 2021 Apr 21.

Department of Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA.

Dentigerous cysts, also known as follicular cysts, are among the most common developmental cysts of the gnathic bones. The majority of cases are clinically asymptomatic and discovered incidentally on panographic radiographs during routine dental care. The cyst appears as a radiolucency, classically unilocular, associated with the crown of an unerupted or impacted tooth. Read More

Indian J Dent Res 2020 Nov-Dec;31(6):987-990

Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Karnataka, India.

Unicytic ameloblastoma is a variant of ameloblastoma encompassing about 6% of ameloblastomas. They represent cystic lesions that reveal clinical and radiographic features of a cyst, but the histopathological features demonstrate a typical ameloblastomatous epithelium lining the cyst. Plexiform unicystic ameloblastoma, a variant of unicystic ameloblastoma refers to the pattern of proliferation where one or more nodules of ameloblastomatous epithelium project from the cystic lining into the lumen demonstrating an edematous plexiform pattern. Read More

Niger J Clin Pract 2021 Mar;24(3):355-361

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Emek-Ankara, Turkey.

Aim: The aims of this study are to investigate the prevalence of odontogenic cysts and tumors occurred in a sample of Turkish population in the last 10 years and to compare the data with latest reports.

Methods And Material: The present retrospective study was carried out at Gazi University, School of Dentistry (GUSD) in Ankara, Turkey. All the data was retrieved from the GUSD archive on patients treated for various oral and maxillofacial lesions between 2008 and 2018. Read More

J Clin Exp Dent 2021 Mar 1;13(3):e278-e286. Epub 2021 Mar 1.

MD, DDS, MS, PhD, EBOS, OMFS. Chairman of Oral and Maxillofacial Surgery. University of Barcelona Dental School. Barcelona, Spain. Director of the Master of Oral Surgery and Buccofacial Implantology of the EFHRE International University / FUCSO. Coordinator / Researcher of the "Dental and Maxillofacial Diseases and Therapeutics" group of the Bellvitge Biomedical Research Institute (IDIBELL).

Background: A literature review was made to determine when third molar (3M) extraction is recommended in symptomatic patients and when it is not recommended.

Material And Methods: A Medline (PubMed) and EMBASE search was made for articles related to indications for the extraction of 3Ms, published in the last 10 years and up until September 2018.

Results: The electronic search yielded 175 articles. Read More

Dentomaxillofac Radiol 2021 Feb 22:20200586. Epub 2021 Feb 22.

Department of Oral Pathology and Oral Biology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Objective: Calcifying odontogenic cysts (COCs) exhibit diverse clinical behaviours and may be associated with other benign odontogenic tumours. In this study, the clinical and radiological features of COCs were analysed according to subtypes based on the classification by Praetorius et al. Emphasis was placed on cases exhibiting atypical or aggressive radiological appearances. Read More

J Oral Maxillofac Surg 2021 May 1;79(5):1081.e1-1081.e9. Epub 2021 Jan 1.

Clinical Instructor, Oral & Maxillofacial Surgery Department, Thomas Jefferson University Hospital, Philadelphia, PA.

Purpose: To assess the prognostic findings of the carcinomatous transformation of odontogenic keratocyst (OKC).

Methods: A systematic review of all cases of carcinomatous transformation of OKC was completed, and a case report was included.

Results: A total of 679 publications were screened, and 37 cases met inclusion criteria. Read More

Indian J Dent Res 2020 Sep-Oct;31(5):803-806

Department of Oral Pathology, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India.

Ameloblastoma is a true benign neoplasm of odontogenic epithelial origin mostly seen in the mandible. After odontoma, it is the second most commonly seen odontogenic neoplasm. Ameloblastoma comprises of several clinical, radiological and histological varieties, making it the most significant odontogenic neoplasm. Read More

Stomatologiia (Mosk) 2020 ;99(6):33-37

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.

Aim: The aim of the study was to improve the types of surgical intervention when performing biopsy of large-sized cystic formations of the lower jaw by cystotomy.

Material And Methods: 44 patients were examined and surgeries were performed: 12 patients with ameloblastoma, 14 - with keratoxystone tumor, 18 - with dentigerous cyst. All patients had a retained tooth in the cyst cavity. Read More

Oral Radiol 2020 Nov 27. Epub 2020 Nov 27.

Department of Oral Pathology and Oral Biology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Ghost cell odontogenic carcinoma (GCOC) is a rare malignant neoplasm, representing 3% of all ghost cell lesions of the jaws. They can arise de novo or from a pre-existing calcifying odontogenic cyst (COC) or dentinogenic ghost cell tumour (DGCT). A systematic review of the literature reported only 12 cases of a GCOC arising from a pre-existing COC. Read More

Int J Surg Case Rep 2020 7;77:371-377. Epub 2020 Nov 7.

Oral and Maxillofacial Surgery Department, Faculty of Dentistry, University of Khartoum, Sudan. Electronic address:

Introduction: Ameloblastoma is a benign neoplasm of odontogenic origin with local invasive characteristics and a high recurrence rate. It compromised 1% of the jaw's cysts and tumors with only 10-15% in children.

Presentation Of Case: A 14-year-old boy sought treatment for a painless swelling involving the right side of the face started one year ago. Read More

Braz Dent J 2020 Sep-Oct;31(5):557-561

Oral Maxillofacial Surgery and Traumatology Department, UFU - Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.

Lesions denominated fibro-osseous lesions of the jaw constitute a diversified group of disorders, in which the normal bone architecture is replaced by fibroblasts, collagen fibers and immature bone. At present, the World Health Organization recognizes four variants of these lesions, namely: bone-cement dysplasia, fibrous dysplasia, ossifying fibroma and Familial gigantiform cementoma. Fibrous dysplasia may present in the monostotic form, affecting one single bone or an isolated craniofacial region; and in the Polyostotic form, involving two or more bones of the skeleton, and eventual association with syndromic conditions. Read More

Contemp Clin Dent 2020 Jan-Mar;11(1):39-45. Epub 2020 Jul 13.

Department of Oral and Maxillofacial Surgery, Saraswati Dental College, Lucknow, Uttar Pradesh, India.

Objective: This study was undertaken to investigate the prevalence of intraosseous jaw lesions among pediatrics (0-15 years of age) in a rural health-care center of Maharashtra and to determine the most common types of lesions and their distribution according to gender and anatomical site involved.

Study Design: Histopathological data were collected from a database of lesions classified as intraosseous jaw lesions dated between January 1, 2005, and December 31, 2015, from the archives of the Department of Oral and Maxillofacial Surgery, Rural Dental College, Maharashtra, India. All the cases of jaw cysts and tumors among children under 16 years of age group were segregated and scrutinized further under the headings of type of pathologies, anatomical locations where they are most commonly seen, and the age/gender most pertinent to these pathologies. Read More

Contemp Clin Dent 2020 Jan-Mar;11(1):20-27. Epub 2020 Jul 13.

Department of Oral Medicine and Radiology, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.

Background: The clinical feature and radiographic appearance of orthokeratinized odontogenic keratocyst (OKC) are not characteristic, which may lead to the misdiagnosis. The radiographic appearance of OKC may range from a small unilocular radiolucency to a large multilocular radiolucency, resembling other odontogenic cysts and tumors.

Aim: The aim was to illustrate the characteristic feature of OKC presented on the digital panoramic radiograph and cone-beam computed tomography (CBCT), which may provide great value for the differential diagnosis and the treatment planning and also to compare the various radiographic features of OKC in CBCT and digital panoramic radiograph. Read More

Minerva Dent Oral Sci 2021 Feb 23;70(1):26-31. Epub 2020 Oct 23.

Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy.

Background: Odontogenic keratocyst (OKC) can be classified as an oral lesion representing the third most common cyst of the jaws characterized by a high rate of recurrence. OKC was accepted as a neoplastic lesion in the 2005 WHO classification and it was called keratocystic odontogenic tumor (KCOT). However, in the 2017 classification of odontogenic tumors, OKC was moved back into the cyst category. Read More

J Oral Maxillofac Surg 2021 Mar 12;79(3):585-597. Epub 2020 Sep 12.

Professor, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital Harvard School of Dental Medicine, Boston, MA. Electronic address:

Purpose: To review the demographic data, presenting symptoms, location, radiographic findings, treatment, and prognosis of pediatric jaw lesions in children treated at a single academic institution.

Patients And Methods: A retrospective medical record review was undertaken of patients younger than 18 years who presented to the Massachusetts General Hospital for Children between 2006 and 2018 with a primary jaw lesion.

Results: About 164 patients were identified. Read More

BMC Oral Health 2020 10 9;20(1):276. Epub 2020 Oct 9.

Department of Oral and Maxillofacial Pathology, Daejeon Dental Hospital, Wonkwang University College of Dentistry, Daejeon, South Korea.

Background: Concomitant cemento-osseous dysplasia (COD) and aneurysmal bone cyst (ABC) are rare in the head and neck region. In our search of the English language literature, we found only one case report describing the simultaneous occurrence of COD and ABC in the head and neck region. Here, we report a case of COD associated with ABC. Read More

Diagn Cytopathol 2021 Mar 25;49(3):E93-E98. Epub 2020 Aug 25.

Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Ameloblastomas are rarely encountered in clinical practice, accounting for only 1% of tumors and cysts of the jaw although they are one of the most common odontogenic neoplasms. The cytological features are described in a few case reports only. The aim of this study was to describe the morphological features of ameloblastoma in fine-needle aspiration cytology (FNAC) and highlight the contribution of cell blocks in their diagnosis. Read More

J Cancer Res Ther 2020 Apr-Jun;16(3):683-685

Department of Oral and Maxillofacial Surgery, JSS Dental College and Hospital, Mysore, Karnataka, India.

Squamous cell carcinomas of the oral cavity are quite common, but primary intraosseous squamous cell carcinomas (PIOSCCs) are rare. Their origin from lining of different odontogenic cysts has been documented. More than 50% of such cases have been reported to occur in periapical inflammatory cysts, and less than 10 cases are reported to arise from odontogenic keratocyst (OKC). Read More

J Cancer Res Ther 2020 Apr-Jun;16(3):641-646

Department of Oral Pathology, A. J. Institute of Dental Sciences, Mangalore, Karnataka, India.

Schwannoma, a benign nerve sheath tumor, is quite rare and more so in jawbones. We report a rare case of a plexiform variant of mandibular schwannoma in a 12-year-old female with a swelling in the left mandible. Clinical features were suggestive of dentigerous cyst as a result of missing premolars and canine. Read More

Med Oral Patol Oral Cir Bucal 2020 Sep 1;25(5):e616-e625. Epub 2020 Sep 1.

Universidade Federal de Uberlândia Faculdade de Odontologia - Área de Patologia Av. Pará, 1720 - Campus Umuarama CEP 38400-902 - Uberlândia / MG, Brazil

Background: The aim of this study was to describe the relative frequency and the main demographic and clinic-radiographic features related to patients diagnosed with Simple bone cyst (SBC) in an Oral Diagnosis Service in Southeast Brazil and present a review and discussion of international literature on this topic.

Material And Methods: SBC cases from our service encompassing the period between 1978 and 2017 were selected. In addition, a literature search was performed in the Pubmed/MEDLINE online electronic database published between 1951 and 2019. Read More

Oral Maxillofac Surg 2021 Mar 17;25(1):89-97. Epub 2020 Jul 17.

Research Department, School of Dentistry, Institución Universitaria Colegios de Colombia, Bogotá, Colombia.

The calcifying odontogenic cyst is as a benign, rare developmental odontogenic cyst with a wide range of histologic characteristics. It may present along with other odontogenic pathologies such as odontoma, ameloblastoma, adenomatoid odontogenic tumor, ameloblastic fibroma, and ameloblastic fibro-odontoma. Clinically, it can be an either intra- or extraosseous painless swelling that can produce cortical expansion. Read More

Clin Pract 2020 May 22;10(2):1205. Epub 2020 Jun 22.

UWA Dental School, University of Western Australia, Nedlands WA, Australia.

Odontogenic keratocyst (OKC) and ameloblastomas are distinct histopathologically diagnosed odontogenic lesions of the oral cavity. Both are primarily located in the posterior regions of the mandible, however, they can involve the maxilla as well. The occurrence of both an OKC and ameloblastoma in a patient is very uncommon. Read More

Oral Maxillofac Surg 2020 Dec 5;24(4):455-460. Epub 2020 Jul 5.

Oral Pathology, Department of Dentistry, Federal University of Rio Grande do Norte-UFRN, Av. Sen Salgado Filho, 1787, Lagoa Nova, Natal, RN, Brazil.

Purpose: Cripto-1 also known as teratoma-derived growth factor 1 (TDGF-1) belongs to the EGF-CFC family of growth factor-like molecules. Cripto-1 is involved with embryonic development and not expressed in adult tissue, but some tumours are accompanied by reactivation.

Methods: The aim of this study was to evaluate the immunohistochemical expression of Cripto-1 in most common odontogenic cysts and tumours. Read More

J Dent (Shiraz) 2020 Jun;21(2):153-157

Postgraduate student, Dept. of Endodontics, Faculty of Dentistry, Tehran Medical Science Islamic Azad University, Tehran, Iran.

Calcifying odontogenic cyst is an uncommon odontogenic lesion that represents less than 2% of all odontogenic cysts and tumors. It usually occurs in incisor and canine areas during the second to fourth decades of life. It can be associated with other lesions like odontoma, ameloblastic fibroma, ameloblastoma, adenomatoid odontogenic tumors, odontoameloblastoma, and odontogenic myxoma. Read More

J Am Vet Med Assoc 2020 Jun;256(12):1359-1367

Objective: To characterize clinical, radiographic, and histologic features of canine furcation cysts (CFCs) in dogs and to propose possible mechanisms of CFC development.

Animals: 20 client-owned dogs with CFCs biopsied between January 1, 2013, and December 31, 2017.

Procedures: Medical records of the Center for Comparative Oral and Maxillofacial Pathology at the University of Wisconsin-Madison were retrospectively searched to identify records of dogs that had surgical biopsy specimens of mandibular or maxillary cavitary lesions diagnosed as odontogenic cysts and that met additional inclusion criteria. Read More

Ned Tijdschr Tandheelkd 2020 Feb;127(2):97-101

A 67-year-old man presented with a swelling on the right side of the mandible. Histopathological investigation of a biopsy revealed a peripheral dentogenic ghost cell tumour. Treatment consisted of thorough excochleation of the abnormality and 2 years after treatment, the patient was free of recurrence. Read More

Curr Med Imaging 2020 ;16(10):1332-1339

Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.

Background: Impacted teeth are commonly asymptomatic and not associated with any pathologic lesions for years. Any change in the size of the follicle associated with impacted teeth may result in odontogenic cysts or tumors. CBCT plays an important role in determining the radiographic features of a lesion and therefore, is very helpful for accurate diagnosis and treatment planning. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):35-42

Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To investigate the clinicopathologic features and prognostic factors in odontogenic keratocyst (OKC), and to provide new reference for clinic treatment and management of these patients.

Methods: Clinicopathological data of 844 cases initially diagnosed as or associated with OKC at Department of Oral Pathology, Peking University Hospital of Stomatology from 2000 to 2018 were collected. The cases were divided into 4 groups: sporadic OKCs (intraosseous, cystic lesion irrelevant to nevoid basal cell carcinoma syndrome), syndromic OKCs, solid OKCs and peripheral OKCs. Read More

Int J Surg Case Rep 2020 27;67:239-244. Epub 2020 Jan 27.

School of Dentistry, Federal University of Pará (UFPA), Belém, PA, Brazil. Electronic address:

Introduction: Odontogenic pathological lesions can generally be divided into cysts and tumors. Calcifying odontogenic cyst (COC) is a non-aggressive odontogenic cyst, however, in a few occasions, COC can show excessive growth and destruction. This study describes an uncommon aggressive presentation of a large COC and discusses the treatment strategies used to achieve a favorable result. Read More