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J Oral Pathol Med 2022 May 15. Epub 2022 May 15.

Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing, PR China.

Background: Orthokeratinized odontogenic cyst (OOC), a newly designated entity of odontogenic cysts, is an intraosseous jaw cyst that is entirely or predominantly lined by orthokeratinized squamous epithelium. The aim of this study was to report a large series of OOC to substantiate its clinicopathologic profiles and to investigate PTCH1 mutations in OOCs.

Method: The clinicopathologic features of 167 OOCs from 159 patients were analyzed and the immunohistochemical expression of markers related to cell differentiation and proliferation was evaluated. Read More

Cureus 2021 Dec 26;13(12):e20701. Epub 2021 Dec 26.

Oral and Maxillofacial Surgery, Saveetha Dental College and Hospital, Chennai, IND.

The glandular odontogenic cyst (GOC) is a rare odontogenic cyst that can develop in the maxillofacial region with aggressive behavior. It tends to develop into enormous proportions with high recurrence rates. The mandibular anterior area is the common site of occurrence of GOC, and it appears as an asymptomatic slow-growing swelling. Read More

Case Rep Dent 2022 22;2022:3118998. Epub 2022 Jan 22.

Marmara University, Istanbul, Turkey.

Eruption of tooth into place other than tooth-bearing region is defined as ectopic eruption. Although ectopic eruption of tooth is rare, there have been cases in the maxillary sinus, mandibular condyle, nasal cavity, chin, palate, and orbital floor. Due to ectopic teeth's rarity and lack of consensus for ıts treatment, incidence was entitled to be added to literature and discussed. Read More

World J Surg Oncol 2022 Jan 27;20(1):25. Epub 2022 Jan 27.

Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.

Background: Primary intraosseous carcinoma (PIOC) is a rare malignant odontogenic tumor that predominantly occurs in males older than 50 years. PIOC can be misdiagnosed as odontogenic cyst because it occasionally shows a well-defined border on radiography. In this study, related literatures of pediatric and adolescent PIOC cases were analyzed under strict PRISMA guidelines along with an adolescent case who was provisionally misdiagnosed as an odontogenic cyst. Read More

Front Oral Health 2021 18;2:677731. Epub 2021 Jun 18.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Aging is not a matter of choice; it is our fate. The "time-dependent functional decline that affects most living organisms" is coupled with several alterations in cellular processes, such as cell senescence, epigenetic alterations, genomic instability, stem cell exhaustion, among others. Age-related morphological changes in dental follicles have been investigated for decades, mainly motivated by the fact that cysts and tumors may arise in association with unerupted and/or impacted teeth. Read More

Diagn Pathol 2021 Oct 17;16(1):91. Epub 2021 Oct 17.

Medical University of Graz, Neue Stiftingtalstraße 6, 8036, Graz, Austria.

Background: The rarity of juvenile psammomatoid ossifying fibroma (JPOF) and lack of cytogenetic studies prompted us to report a novel SETD2 gene mutation in a benign odontogenic tumour.

Case Presentation: A 21-year-old man presented with a hard, expanded mandibular cortex. Computed tomography revealed multilocular radiopacity in the mandible; this was reconstructed via segmental mandibulectomy using a vascularised iliac crest flap. Read More

Minerva Dent Oral Sci 2022 Feb 11;71(1):48-52. Epub 2021 Oct 11.

Division of Pathology, Hospital of Vercelli, Vercelli, Italy.

Introduction: The aim of the present article was to review and depict the main radiological features of odontogenic keratocysts (OKCs), thus helping the differential diagnoses from other odontogenic cysts and neoplasms.

Evidence Acquisition: A review of articles published between January 2000 and October 2020 using Medline and the MeSH Term "odontogenic keratocyst" in combination with the following terms "imaging," "radiology," "panoramic radiograph," and "computed tomography," was performed.

Evidence Synthesis: Radiographically, OKCs are well-defined unilocular or multilocular radiolucencies bounded by corticated margins. Read More

J Craniomaxillofac Surg 2022 Jan 4;50(1):1-6. Epub 2021 Oct 4.

Division of Dentistry, Vercelli Hospital, Vercelli, Italy.

The objective of the present study was to assess the epidemiology including demographic variables, diagnostic features, and the management of odontogenic keratocyst (OKCs) at several European departments of maxillofacial and oral surgery. This study is based on a systematic computer-assisted database that allowed the recording of data from treated OKCs. The following data were recorded for each patient: gender, age, voluptuary habits, comorbidities, site, size, radiographic features, treatment of OKCs, length of hospital stay, complications, recurrence, management and complications of eventual recurrence. Read More

J Craniofac Surg 2022 May 23;33(3):870-874. Epub 2021 Sep 23.

Department of Plastic Surgery, University of Kansas Medical Center.

Background: Although pathology in the maxillary and mandibular bones is rare in young patients, the differential diagnosis is broad. The World Health Organization (WHO) updated its classification of maxillofacial bone pathology in 2017. Using these updated guidelines, a systematic review of common maxillofacial bone lesions in the pediatric population was performed. Read More

J Craniofac Surg 2022 May 17;33(3):e294-e298. Epub 2021 Sep 17.

Department for Oral and Craniomaxillofacial and Plastic Surgery, University Hospital Cologne and Faculty of Medicine, University of Cologne, Germany.

Purpose: The authors conducted this study to provide morphological and volumetric data of recurrent odontogenic keratocysts of the upper and lower jaw to emphasize risk factors in accordance with their radiological appearance and guide clinical decisions for jeopardized patients.

Methods: By applying the open-source software "ITK-Snap" on cone-beam computed tomography images, volumetric measurements of histopathologically diagnosed recurrent odontogenic keratocysts could be performed. For statistical investigations, descriptive statistics and independent Student t test were performed. Read More

J Oral Pathol Med 2022 Jan 20;51(1):5-12. Epub 2021 Sep 20.

Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Brazil.

Background: Hybrid odontogenic lesions combine histopathological characteristics of two or more odontogenic cysts and/or tumours. The aim of this study was to evaluate the available data on hybrid odontogenic lesions (HOL) and to analyse their epidemiological/clinical features and biological behaviour.

Methods: An electronic search was done in January 2021 using multiple databases. Read More

Oral Maxillofac Surg 2022 Jun 29;26(2):291-298. Epub 2021 Jul 29.

Oral and Maxillofacial Surgery Residency Program, School of Dental Medicine, University of Puerto Rico - Medical Sciences Campus, Paseo Dr. José Celso Barbosa, San Juan, 00921, Puerto Rico.

Aim: The purpose of this study was to compare the histopathologic findings of pre- and post-active decompression of odontogenic keratocyst and to establish if such findings were consistent.

Materials And Methods: A retrospective case series from a group of patients diagnosed with odontogenic keratocyst who underwent active decompression and distraction sugosteogenesis followed by final enucleation was designed and implemented. The dependent variable was changed in histologic diagnosis, as evaluated by an oral and maxillofacial pathologist. Read More

PLoS One 2021 20;16(7):e0254997. Epub 2021 Jul 20.

Daegyeong Division, Korea Institute of Industrial Technology, Daegu, Republic of Korea.

This study aimed to develop a high-performance deep learning algorithm to differentiate Stafne's bone cavity (SBC) from cysts and tumors of the jaw based on images acquired from various panoramic radiographic systems. Data sets included 176 Stafne's bone cavities and 282 odontogenic cysts and tumors of the mandible (98 dentigerous cysts, 91 odontogenic keratocysts, and 93 ameloblastomas) that required surgical removal. Panoramic radiographs were obtained using three different imaging systems. Read More

J Stomatol Oral Maxillofac Surg 2022 06 16;123(3):e57-e61. Epub 2021 Jul 16.

Université de Paris, Paris, France; Service de chirurgie maxillofaciale et chirurgie plastique, 149 rue de Sèvres, 75015 Paris, France; Centre de Références de Maladies Rares des fentes et malformations faciales. Electronic address:

Objectives: Nevoid Basal Cell Carcinoma Syndrome (NBCS) is a rare genetic condition affecting multiple organs including the maxillofacial and dental region. The surgical removal of the odontogenic keratocystic tumors (OKT), the high rate of recurrence leads to a iatrogenic tooth loss requiring dental care. The aim of this study is therefore to describe the dental and orthodontic management, and to assess the impact of surgery on facial growth and oral development. Read More

Diagn Pathol 2021 Jul 11;16(1):61. Epub 2021 Jul 11.

Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Faculty of Dentistry, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkoucho-dori, Chuo-ku, 951-8514, Niigata, Japan.

Background: Central mucoepidermoid carcinoma (MEC) is a rare salivary gland tumor that affects the jawbone. Glandular odontogenic cyst (GOC) is also a rare odontogenic developmental cyst with glandular differentiation. GOC shares some histological features with central MEC, and a pre-existing GOC can develop into central MEC. Read More

Oral Maxillofac Surg 2022 Jun 28;26(2):239-245. Epub 2021 Jun 28.

PGY2, Oral and Maxillofacial Surgery Residency Program, School of Dental Medicine, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico.

Purpose: The aim of this paper is to describe active decompression and distraction sugosteogenesis as an alternative for the management of odontogenic cystic lesions. The technique, demographics, success rate, and complications will be presented.

Patients And Methods: A retrospective case series study design was implemented. Read More

Head Neck Pathol 2022 Mar 28;16(1):248-256. Epub 2021 Jun 28.

Homi Bhabha National Institute, Mumbai, 400012, India.

Ossifying fibromas of the head and neck region are classified as cemento-ossifying fibroma (COF) (odontogenic origin), and two types of juvenile ossifying fibromas: juvenile trabecular ossifying fibroma (JTOF), and juvenile psammomatous ossifying fibroma (JPOF). The potential for recurrence in JTOF and JPOF and the discovery of newer molecular signatures necessitates accurate histological classification. Over 12 years (2005-2017), a total of 45 patients with 51 tumours were retrieved and reviewed for clinic-pathological features from the archives of a tertiary care oncology centre. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 09 27;132(3):e82-e85. Epub 2021 Feb 27.

Oral and Maxillofacial Surgery, St. George's Hospital, London, United Kingdom.

Odontogenic keratocysts (OKCs) are a commonly occurring, benign cystic intraosseous lesion thought to arise from the cell rests of the dental lamina. Most instances of OKC are commonly found in the posterior aspect of the mandible. In rare instances, there have been reported cases of OKCs arising in the peripheral gingiva, but these cases are few and far between. Read More

J Oral Biosci 2021 09 16;63(3):271-277. Epub 2021 May 16.

Departmento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico. Electronic address:

Objectives: Ameloblastoma is an odontogenic neoplasm of the mandible and maxilla with various histological types and subtypes. It has been reported that some ameloblastomas could arise from dentigerous cyst walls; thus, the development of ameloblastoma from dentigerous cysts may be due to differential protein expression. Our aim was to identify a membrane protein that is differentially expressed in ameloblastomas with respect to dentigerous cysts. Read More

J Oral Maxillofac Surg 2021 Sep 24;79(9):1874-1881. Epub 2021 Mar 24.

Raymond P. White Distinguished Professor and Chair of Oral and Maxillofacial Surgery, UNC Adams School of Dentistry Division of Craniofacial and Surgical Services, UNC Adams School of Dentistry, Chapel Hill, NC.

Purpose: Carnoy's solution (CS), the gold standard for adjunctive chemical cautery in treatment of odontogenic keratocysts (OKCs), has been banned for 7 years, leading to substitution with the non-chloroform containing modified Carnoy's solution (MC) without data to support its effectiveness. We performed this study to compare the earlier data with CS to the more current outcomes with MC.

Methods: A retrospective cohort study was conducted on patients diagnosed with OKC and treated by a single surgeon (GHB) with enucleation and curettage (EC), peripheral ostectomy, and application of CS or MC. Read More

Head Neck Pathol 2021 Dec 21;15(4):1261-1264. Epub 2021 Apr 21.

Department of Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA.

Dentigerous cysts, also known as follicular cysts, are among the most common developmental cysts of the gnathic bones. The majority of cases are clinically asymptomatic and discovered incidentally on panographic radiographs during routine dental care. The cyst appears as a radiolucency, classically unilocular, associated with the crown of an unerupted or impacted tooth. Read More

Med Oral Patol Oral Cir Bucal 2021 Jul 1;26(4):e502-e509. Epub 2021 Jul 1.

Post graduation Program in Dentistry, Estácio de Sá University Av. Alfredo Baltazar da Silveira, 580 cobertura CEP 22790-701, Recreio dos Bandeirantes, Rio de Janeiro/RJ, Brazil

Background: Several nonendodontic diseases can occur in the periapical region, resembling endodontic inflammatory conditions. Therefore, the aim of the present study was to determine the frequency of nonendodontic periapical lesions diagnosed in a Brazilian population.

Material And Methods: The files of two Oral Pathology laboratories were reviewed and all cases including at least one clinical diagnosis of endodontic periapical lesions were selected for the study. Read More

Indian J Dent Res 2020 Nov-Dec;31(6):987-990

Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Karnataka, India.

Unicytic ameloblastoma is a variant of ameloblastoma encompassing about 6% of ameloblastomas. They represent cystic lesions that reveal clinical and radiographic features of a cyst, but the histopathological features demonstrate a typical ameloblastomatous epithelium lining the cyst. Plexiform unicystic ameloblastoma, a variant of unicystic ameloblastoma refers to the pattern of proliferation where one or more nodules of ameloblastomatous epithelium project from the cystic lining into the lumen demonstrating an edematous plexiform pattern. Read More

Head Neck Pathol 2021 Mar 15;15(1):107-112. Epub 2021 Mar 15.

Emory University School of Medicine, Atlanta Oral Pathology, Decatur, GA, 30033, USA.

Odontogenic cysts are categorized as inflammatory and developmental. Of the developmental odontogenic cysts, the dentigerous cyst is the most common and by definition is attached to the cervical region of an unerupted tooth. The cyst envelops the crown forming a sac. Read More

Niger J Clin Pract 2021 Mar;24(3):355-361

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Emek-Ankara, Turkey.

Aim: The aims of this study are to investigate the prevalence of odontogenic cysts and tumors occurred in a sample of Turkish population in the last 10 years and to compare the data with latest reports.

Methods And Material: The present retrospective study was carried out at Gazi University, School of Dentistry (GUSD) in Ankara, Turkey. All the data was retrieved from the GUSD archive on patients treated for various oral and maxillofacial lesions between 2008 and 2018. Read More

Oral Dis 2022 May 21;28(4):1198-1206. Epub 2021 Mar 21.

Health Care Department, Metropolitan Autonomous University-Xochimilco, Mexico City, Mexico.

Objective: The aim of this study is to present and discuss the salient clinicopathological features, differential diagnosis and epithelial immunohistochemical profile of three additional cases of peripheral odontogenic keratocyst (POKC) and to present a review of the literature. POKC is a locally aggressive odontogenic lesion. The peripheral variant of the odontogenic keratocyst is rare and more frequently located in anterior gingiva. Read More

J Clin Exp Dent 2021 Mar 1;13(3):e278-e286. Epub 2021 Mar 1.

MD, DDS, MS, PhD, EBOS, OMFS. Chairman of Oral and Maxillofacial Surgery. University of Barcelona Dental School. Barcelona, Spain. Director of the Master of Oral Surgery and Buccofacial Implantology of the EFHRE International University / FUCSO. Coordinator / Researcher of the "Dental and Maxillofacial Diseases and Therapeutics" group of the Bellvitge Biomedical Research Institute (IDIBELL).

Background: A literature review was made to determine when third molar (3M) extraction is recommended in symptomatic patients and when it is not recommended.

Material And Methods: A Medline (PubMed) and EMBASE search was made for articles related to indications for the extraction of 3Ms, published in the last 10 years and up until September 2018.

Results: The electronic search yielded 175 articles. Read More

Int J Oral Maxillofac Surg 2021 Sep 2;50(9):1168-1176. Epub 2021 Mar 2.

Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India. Electronic address:

The objective of this study was to describe the authors' long-term experience with the management of odontogenic keratocysts (OKCs). All OKC cases treated at the study centre between 1999 and 2015, with a minimum of 5 years of follow-up by December 2019, were reviewed retrospectively. Operative procedures including decompression/marsupialization, enucleation (E), E+Carnoy's solution (CS), E+CS+peripheral ostectomy (PO), and resection were assessed for complete resolution, partial resolution, and recurrence rates. Read More

Dentomaxillofac Radiol 2021 Sep 22;50(6):20200586. Epub 2021 Feb 22.

Department of Oral Pathology and Oral Biology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Objective: Calcifying odontogenic cysts (COCs) exhibit diverse clinical behaviours and may be associated with other benign odontogenic tumours. In this study, the clinical and radiological features of COCs were analysed according to subtypes based on the classification by Praetorius et al. Emphasis was placed on cases exhibiting atypical or aggressive radiological appearances. Read More

J Oral Maxillofac Surg 2021 May 1;79(5):1081.e1-1081.e9. Epub 2021 Jan 1.

Clinical Instructor, Oral & Maxillofacial Surgery Department, Thomas Jefferson University Hospital, Philadelphia, PA.

Purpose: To assess the prognostic findings of the carcinomatous transformation of odontogenic keratocyst (OKC).

Methods: A systematic review of all cases of carcinomatous transformation of OKC was completed, and a case report was included.

Results: A total of 679 publications were screened, and 37 cases met inclusion criteria. Read More