127 results match your criteria Management of the N3 Neck


Neck management in head and neck squamous cell carcinomas: where do we stand?

Med Oncol 2019 Mar 27;36(5):40. Epub 2019 Mar 27.

Radiation Oncology Department, François Baclesse Center/ARCHADE, Normandy University, 3 Avenue du Général Harris, 14000, Caen, France.

Head and neck squamous-cell carcinomas (HNSCCs) have a significant lymph node tropism. This varies considerably depending on the primary tumor site and the Human Papillomavirus (HPV) status of the disease. The best therapeutic option, between up-front lymph node dissection and chemoradiotherapy (CRT) +/- followed by lymph node dissection in case of persistent lymphadenopathy or regional relapse, remains unclear. Read More

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http://dx.doi.org/10.1007/s12032-019-1265-1DOI Listing
March 2019
1 Read

Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial.

Lancet 2019 01 15;393(10166):40-50. Epub 2018 Nov 15.

Department of Radiation Oncology, Stanford University, Stanford, CA, USA.

Background: Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma have high survival when treated with radiotherapy plus cisplatin. Whether replacement of cisplatin with cetuximab-an antibody against the epidermal growth factor receptor-can preserve high survival and reduce treatment toxicity is unknown. We investigated whether cetuximab would maintain a high proportion of patient survival and reduce acute and late toxicity. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32779-XDOI Listing
January 2019
15 Reads

Primary Penile Cancer: The Role of Adjuvant Radiation Therapy in the Management of Extranodal Extension in Lymph Nodes.

Eur Urol Focus 2018 Oct 13. Epub 2018 Oct 13.

Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL, USA.

Background: In head and neck cancer, the presence of extranodal extension (ENE) in lymph nodes (LNs) has been shown prospectively to require adding chemotherapy to postoperative radiation therapy (RT). Limited data exist regarding ENE in LNs from primary penile cancer (PeCa).

Objective: To determine the association of RT and ENE in PeCa. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24054569183030
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http://dx.doi.org/10.1016/j.euf.2018.10.007DOI Listing
October 2018
5 Reads

PET and Neck Ultrasound for the Detection of Cervical Lymphadenopathy in Patients with Lung Cancer and Mediastinal Lymphadenopathy.

Respiration 2018 4;96(2):138-143. Epub 2018 Jul 4.

Interventional Respiratory Unit, Galway University Hospital, Galway, Ireland.

Background: Cervical lymph nodes are frequently involved in patients with lung cancer and indicate inoperability. Some guidelines recommend neck ultrasound (NUS) in patients with bulky mediastinal lymphadenopathy. Positron emission tomography (PET) is indicated for patients with potentially curable disease. Read More

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https://www.karger.com/Article/FullText/487957
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http://dx.doi.org/10.1159/000487957DOI Listing
December 2018
9 Reads

Induction chemotherapy followed by concurrent chemoradiation versus concurrent chemoradiation alone in the definitive management of p16-positive oropharyngeal squamous cell carcinoma with low-neck or N3 disease.

Oral Oncol 2018 Mar 20;78:151-155. Epub 2018 Feb 20.

Southern California Permanente Medical Group, Department of Radiation Oncology, Los Angeles, CA, United States. Electronic address:

Objective: The addition of induction chemotherapy (ICT) to concurrent chemoradiation (CCRT) has been investigated as a method of improving outcomes among patients with locally advanced head and neck squamous cell carcinoma. Previous studies have consisted of heterogeneous populations with both p16-positive and p16-negative disease and varying extent of nodal disease burden. We evaluated the role of ICT in p16-positive oropharyngeal squamous cell carcinoma (OPSCC) at high-risk of distant failure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183004
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http://dx.doi.org/10.1016/j.oraloncology.2018.01.031DOI Listing
March 2018
7 Reads

Importance of lymph node ratio for locoregional recurrence of squamous cell carcinoma of the buccal mucosa.

Head Neck 2017 12 5;39(12):2488-2493. Epub 2017 Oct 5.

Department of Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Cologne, Germany.

Background: There is no published study on the influence of lymph node ratio on locoregional recurrence of squamous cell carcinoma (SCC) of the buccal mucosa. Therefore, we focused in our study on this specific anatomic subsite.

Methods: We conducted a retrospective chart review of 95 patients from 2003-2013 with treatment-naive SCC of the buccal mucosa. Read More

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http://dx.doi.org/10.1002/hed.24922DOI Listing
December 2017
19 Reads

[Management of T3 supraglottic carcinoma: a retrospective study].

Zhonghua Zhong Liu Za Zhi 2017 Aug;39(8):613-617

Department of Head and Neck Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

To discuss the strategy of therapeutic management of T3 supraglottic carcinoma. A retrospective analysis of 459 patients with T3 supraglottic carcinoma treated in our hospital was performed. We evaluated the results of different managements, including surgery alone, preoperative radiotherapy, postoperative radiotherapy and radiotherapy alone. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2017.08.010DOI Listing
August 2017
7 Reads

Clinical outcomes for patients presenting with N3 head and neck squamous cell carcinoma: Analysis of the National Cancer Database.

Head Neck 2017 11 24;39(11):2159-2170. Epub 2017 Jul 24.

Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Background: There is a paucity of data regarding head and neck squamous cell carcinomas (HNSCCs) and N3 nodal disease.

Methods: Retrospective analysis of patients with N3 HNSCC identified in the National Cancer Database (NCDB) was performed.

Results: We identified 4867 patients with N3 HNSCC treated with primary surgery or chemoradiotherapy (CRT). Read More

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http://dx.doi.org/10.1002/hed.24881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647211PMC
November 2017
4 Reads

Prognostic factors for head and neck cancer of unknown primary including the impact of human papilloma virus infection.

J Otolaryngol Head Neck Surg 2017 Jun 10;46(1):45. Epub 2017 Jun 10.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Gothenburg, Sahlgrenska University Hospital, Göteborg, Sweden.

Background: Head and neck cancer of unknown primary (HNCUP) is rare and prospective studies are lacking. The impact of different prognostic factors such as age and N stage is not completely known, the optimal treatment is not yet established, and the reported survival rates vary. In the last decade, human papilloma virus (HPV) has been identified as a common cause of and important prognostic factor in oropharyngeal cancer, and there is now growing interest in the importance of HPV for HNCUP. Read More

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http://journalotohns.biomedcentral.com/articles/10.1186/s404
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http://dx.doi.org/10.1186/s40463-017-0223-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466757PMC
June 2017
10 Reads

PP2A deactivation is a common event in oral cancer and reactivation by FTY720 shows promising therapeutic potential.

J Cell Physiol 2018 Feb 12;233(2):1300-1311. Epub 2017 Jun 12.

Environment-Omics-Diseases Research Center, China Medical University Hospital, Taichung, Taiwan.

Protein phosphatase 2A (PP2A) is a tumor suppressor gene, that has been frequently deactivated in many types of cancer. However, its molecular and clinical relevance in oral squamous cell carcinoma (OSCC) remain unclear. Here we show that, PP2A deactivation is a common event in oral cancer cells and hyperphosphorylation in its tyrosine-307 (Y307) residue contributes to PP2A deactivation. Read More

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http://dx.doi.org/10.1002/jcp.26001DOI Listing
February 2018
39 Reads

PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography-computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer.

Health Technol Assess 2017 04;21(17):1-122

Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.

Background: Planned neck dissection (ND) after radical chemoradiotherapy (CRT) for locally advanced nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) remains controversial. Thirty per cent of ND specimens show histological evidence of tumour. Consequently, a significant proportion of clinicians still practise planned ND. Read More

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http://dx.doi.org/10.3310/hta21170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410631PMC
April 2017
55 Reads
5.027 Impact Factor

Unknown primary head and neck squamous cell carcinoma in the era of fluorodeoxyglucose-positron emission tomography/CT and intensity-modulated radiotherapy.

Head Neck 2017 07 28;39(7):1382-1391. Epub 2017 Mar 28.

Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Background: The diagnosis and treatment of head and neck carcinoma of unknown primary (CUP) have changed with the introduction of fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT and intensity-modulated radiotherapy (IMRT), with potential implications for outcome.

Methods: We conducted a retrospective analysis of 80 patients with head and neck CUP who were PET-staged and treated with curative intention using IMRT between 2006 and 2016 in the Netherlands Cancer Institute. Patient, tumor, and treatment demographics were recorded and oncologic outcomes were analyzed. Read More

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http://dx.doi.org/10.1002/hed.24762DOI Listing
July 2017
2 Reads

Survival impact of induction chemotherapy in advanced head and neck cancer: A National Cancer Database analysis.

Head Neck 2017 06 16;39(6):1113-1121. Epub 2017 Mar 16.

Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado.

Background: Adding induction chemotherapy to concurrent chemotherapy and radiotherapy (RT) has generally not improved the overall survival (OS) in randomized trials of patients with head and neck cancer. This failure may stem from inadequate power or inappropriate patient selection, prompting this National Cancer Data Base analysis.

Methods: 8031 patients with T4 or N2b to N3 disease undergoing RT and chemotherapy were divided into induction chemotherapy and concurrent chemotherapy cohorts. Read More

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http://dx.doi.org/10.1002/hed.24739DOI Listing
June 2017
13 Reads

Therapeutic Management of Pyriform Sinus Cancer.

Otolaryngol Head Neck Surg 2017 03 10;156(3):498-503. Epub 2017 Jan 10.

1 ENT and Head and Neck Surgery Department, University Hospital of Amiens, Amiens, France.

Objective To analyze the survival rate of a nonselected pyriform sinus cancer population. Study Design Case series with chart review. Setting University hospital. Read More

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http://dx.doi.org/10.1177/0194599816686335DOI Listing
March 2017
6 Reads

Laryngeal cancer: United Kingdom National Multidisciplinary guidelines.

J Laryngol Otol 2016 May;130(S2):S75-S82

Department of ENT-Head and Neck Surgery,Derby Royal Hospitals NHS Foundation Trust,Derby,UK.

This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. Significantly new data have been published on laryngeal cancer management since the last edition of the guidelines. This paper discusses the evidence base pertaining to the management of laryngeal cancer and provides updated recommendations on management for this group of patients receiving cancer care. Read More

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http://dx.doi.org/10.1017/S0022215116000487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873912PMC
May 2016
3 Reads

Reevaluation of postoperative radiation dose in the management of human papillomavirus-positive oropharyngeal cancer.

Head Neck 2016 11 6;38(11):1643-1649. Epub 2016 May 6.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.

Background: The purpose of this study was to compare outcomes of patients with p16-positive oropharyngeal squamous cell carcinoma (SCC) treated with postoperative intensity-modulated radiotherapy (IMRT) before and after an institutional dose reduction policy effective on February 2009.

Methods: Between 1998 and 2013, 175 consecutive patients with p16-positive oropharyngeal SCC with extracapsular extension (ECE) and/or close or positive margins were treated postoperatively to 66 Gy (n = 109) or 60 Gy (n = 66) in 2 Gy/fx.

Results: Between the 66 and 60 Gy groups, there was no difference in tumor classification (pT4 vs pT1-T3; p = . Read More

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http://dx.doi.org/10.1002/hed.24486DOI Listing
November 2016
12 Reads

Increasing use of nonsurgical therapy in advanced-stage oral cavity cancer: A population-based study.

Head Neck 2017 01 19;39(1):82-91. Epub 2016 Sep 19.

Otolaryngology Head and Neck Surgery, The University of Utah School of Medicine, Salt Lake City, Utah.

Background: National guidelines support surgical-based treatment and offer nonsurgical therapy as an alternative for advanced-stage oral cavity squamous cell carcinoma (SCC). There are limited data evaluating current utilization of these therapies and their survival outcomes.

Methods: A total of 5856 patients were found in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2008 with resectable advanced-stage oral cavity SCC tumors. Read More

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http://dx.doi.org/10.1002/hed.24542DOI Listing
January 2017
7 Reads

Oncologic outcomes of selective neck dissection in HPV-related oropharyngeal squamous cell carcinoma.

Laryngoscope 2017 03 16;127(3):623-630. Epub 2016 Sep 16.

Head and Neck Surgery Center of Florida, Celebration Hospital, Celebration, Florida, U.S.A.

Objectives: To examine outcomes of selective neck dissection (SND) in patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) who present with clinical neck disease.

Study Design: Multi-institutional retrospective review.

Methods: Two institutional databases of patients with HPV-related OPSCC were reviewed to identify patients with clinical (c) N1-N3 neck disease who underwent SND ± adjuvant therapy. Read More

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http://dx.doi.org/10.1002/lary.26272DOI Listing
March 2017
10 Reads

Prognostic Value of p16 Status on the Development of a Complete Response in Involved Oropharynx Cancer Neck Nodes After Cisplatin-Based Chemoradiation: A Secondary Analysis of NRG Oncology RTOG 0129.

Int J Radiat Oncol Biol Phys 2016 10 28;96(2):362-371. Epub 2016 May 28.

Stanford University Medical Center, Stanford, California.

Purpose: To determine the relationship between p16 status and the regional response of patients with node-positive oropharynx cancer treated on NRG Oncology RTOG 0129.

Methods And Materials: Patients with N1-N3 oropharynx cancer and known p16 status who underwent treatment on RTOG 0129 were analyzed. Pathologic complete response (pCR) rates in patients treated with a postchemoradiation neck dissection (with p16-positive or p16-negative cancer) were compared by Fisher exact test. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078986PMC
http://dx.doi.org/10.1016/j.ijrobp.2016.05.026DOI Listing
October 2016
20 Reads

PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer.

N Engl J Med 2016 Apr 23;374(15):1444-54. Epub 2016 Mar 23.

From the Institute of Head and Neck Studies and Education, University of Birmingham (H.M.), and University Hospitals Birmingham (A.G.J.H.), Birmingham, Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood (W.-L.W.), Warwick Clinical Trials Unit, University of Warwick, Coventry (C.C.M., J.K.R., J.D.), Newcastle University, Newcastle upon Tyne (Max Robinson), Royal Marsden Hospital, London (C.N.), Cardiff University, Cardiff (N.P.), Bristol Haematology and Oncology Centre, Bristol (H.A.-B.), Weston Park Hospital, Sheffield (Martin Robinson), Western General Hospital, Edinburgh (E.J.), Beatson West of Scotland Cancer Centre, Glasgow (M. Rizwanullah), University of Liverpool, Liverpool (H.W.), and the Academic Unit of Health Economics, University of Leeds, Leeds (C.H., A.F.S., P.H.) - all in the United Kingdom; and the Pathology Department, Universidade Federal do Espírito Santo, Vitória, Brazil (S.V.Z.).

Background: The role of image-guided surveillance as compared with planned neck dissection in the treatment of patients with squamous-cell carcinoma of the head and neck who have advanced nodal disease (stage N2 or N3) and who have received chemoradiotherapy for primary treatment is a matter of debate.

Methods: In this prospective, randomized, controlled trial, we assessed the noninferiority of positron-emission tomography-computed tomography (PET-CT)-guided surveillance (performed 12 weeks after the end of chemoradiotherapy, with neck dissection performed only if PET-CT showed an incomplete or equivocal response) to planned neck dissection in patients with stage N2 or N3 disease. The primary end point was overall survival. Read More

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http://dx.doi.org/10.1056/NEJMoa1514493DOI Listing
April 2016
28 Reads
28 Citations
55.873 Impact Factor

Increase in primary surgical treatment of T1 and T2 oropharyngeal squamous cell carcinoma and rates of adverse pathologic features: National Cancer Data Base.

Cancer 2016 05 11;122(10):1523-32. Epub 2016 Mar 11.

Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: There has been increasing interest in the primary surgical treatment of patients with early T classification (T1-T2) oropharyngeal squamous cell carcinoma (OPSCC), with the stated goal of de-escalating or avoiding adjuvant treatment. Herein, the authors sought to determine the degree to which this interest has translated into changes in practice patterns, and the rates of adverse postoperative pathologic features.

Methods: Patients with T1 to T2 OPSCC in the National Cancer Data Base who were treated from 2004 through 2013 were categorized as receiving primary surgical or primary radiation-based treatment. Read More

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http://dx.doi.org/10.1002/cncr.29938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860079PMC
May 2016
33 Reads

Residual neck disease management in squamous-cell carcinoma of the head and neck treated with radiotherapy plus cetuximab.

Clin Transl Oncol 2016 Nov 10;18(11):1140-1146. Epub 2016 Mar 10.

Medical Oncology Department, Institut Català Oncologia, Avinguda de la Granvia de l'Hospitalet, 199-203, 08908, Hospitalet de Llobregat, Spain.

Purpose: Management of residual neck disease (RND) is one of the unsolved points after bio-radiotherapy (BRT) in loco-regional advanced squamous-cell carcinoma of the head and neck (SCCHN). The aims of the study were to characterize the radiological pattern of response by computed tomography (CT) and to assess the role of positron-emission tomography (PET)/CT in this setting for a better decision-making in the indication of neck dissection (ND).

Methods: We retrospectively reviewed 202 patients consecutively diagnosed with node-positive SCCHN (N1: 24; N2: 152; N3: 26) who had been treated with concomitant radiotherapy and cetuximab with or without previous induction chemotherapy between 2006 and 2013. Read More

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http://dx.doi.org/10.1007/s12094-016-1496-yDOI Listing
November 2016
3 Reads

Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) association with lymph node metastasis predicts poor survival in oral squamous cell carcinoma patients.

Oncotarget 2016 Mar;7(10):10879-90

Environment-Omics-Diseases Research, China Medical University Hospital, Taichung, Taiwan.

Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) is a multifunctional protein aberrantly expressed in various types of cancers. However, its expression pattern and clinical significance in oral squamous cell carcinoma (OSCC) remains unclear. In this study, we immunohistochemically investigated the expression pattern of ANP32A in 259 OSCC patients and the results were correlated with clinicopathological factors using Allred, Klein and Immunoreactive scoring (IRS) system. Read More

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http://dx.doi.org/10.18632/oncotarget.7681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905446PMC
March 2016
7 Reads

Hypopharyngeal squamous cell carcinoma: Three-dimensional or Intensity-modulated radiotherapy? A single institution's experience.

Laryngoscope 2016 Mar 24;126(3):620-6. Epub 2015 Nov 24.

Department of Radiation Oncology.

Objectives/hypothesis: Compare outcomes of hypopharyngeal carcinoma that received conventional radiotherapy versus intensity-modulated radiotherapy (IMRT).

Study Design: Retrospective single-institution trial.

Methods: Between April 1990 and May 2011, 100 patients with hypopharyngeal cancer underwent curative radiotherapy (RT) at our institution: 50 with IMRT and 50 with conventional RT. Read More

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http://dx.doi.org/10.1002/lary.25509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940128PMC
March 2016
20 Reads

Proposal for the 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy.

Cancer 2016 Feb 20;122(4):546-58. Epub 2015 Nov 20.

Clinical Oncology Center, University of Hong Kong-Shenzhen Hospital, Shenzhen, China.

Background: An accurate staging system is crucial for cancer management. Evaluations for continual suitability and improvement are needed as staging and treatment methods evolve.

Methods: This was a retrospective study of 1609 patients with nasopharyngeal carcinoma investigated by magnetic resonance imaging, staged with the 7th edition of the American Joint Committee on Cancer (AJCC)/International Union Against Cancer (UICC) staging system, and irradiated by intensity-modulated radiotherapy at 2 centers in Hong Kong and mainland China. Read More

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http://dx.doi.org/10.1002/cncr.29795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968037PMC
February 2016
35 Reads

The Evolution of and Risk Factors for Neck Muscle Atrophy and Weakness in Nasopharyngeal Carcinoma Treated With Intensity-Modulated Radiotherapy: A Retrospective Study in an Endemic Area.

Medicine (Baltimore) 2015 Aug;94(31):e1294

From the Department of Radiation Oncology (L-LZ, Y-PM, G-QZ, L-LT, Z-YQ, LL, J-JY, JM, YS), State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University; and Department of Medical Statistics and Epidemiology (A-HL), School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China.

The aim of this study was to investigate the evolution of sternocleidomastoid muscle (SCM) atrophy in nasopharyngeal carcinoma (NPC) patients following intensity-modulated radiotherapy (IMRT), and the relationship between SCM atrophy and neck weakness.Data were retrospectively analyzed from 223 biopsy-proven NPC patients with no distant metastasis who underwent IMRT with or without chemotherapy. The volume of SCM was measured on pretreatment magnetic resonance imaging (MRI), and MRIs were conducted 1, 2, and 3 years after the completion of IMRT. Read More

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http://dx.doi.org/10.1097/MD.0000000000001294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616570PMC
August 2015
10 Reads

Treatment of T3 laryngeal cancer in the Netherlands: a national survey.

Radiat Oncol 2015 Jun 26;10:134. Epub 2015 Jun 26.

Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Background: Treatment strategies for T3 laryngeal carcinoma include radiotherapy (RT) with or without chemotherapy (CT) and sometimes surgery. We conducted a national survey to determine how T3 laryngeal carcinoma is currently being managed in the Netherlands.

Methods: A questionnaire on general treatment policy, also inquiring details on RT and CT, was sent to all 13 radiotherapy departments accredited for treatment of head and neck cancer (HNC) in the Netherlands. Read More

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http://dx.doi.org/10.1186/s13014-015-0440-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480981PMC
June 2015
2 Reads

Complications of neck dissection at a tertiary level hospital: study of 30 cases.

Mymensingh Med J 2014 Oct;23(4):658-66

Dr Mostafa Kamal Masud, Registrar, Department of ENT, Mymensingh Medical college Hospital, Mymensingh, Bangladesh.

Metastatic dissemination into lymph nodes of neck occurs frequently in head neck cancers which down grade the patient's curability and survival. Neck dissection is a curable option for its management. To evaluate the complications following different types of neck dissection. Read More

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October 2014
1 Read

Obstructive sleep apnea and pulmonary function in patients with severe obesity before and after bariatric surgery: a randomized clinical trial.

Multidiscip Respir Med 2014 9;9(1):43. Epub 2014 Aug 9.

Sleep Laboratory; Master's and PhD Degree Pos Graduation Programs in Rehabilitation Sciences, Nove de Julho University (UNINOVE), Rua Vergueiro 235, Liberdade CEP 01504-001, Sao Paulo, SP, Brazil.

Background: The increasing prevalence of obesity in both developed and developing countries is one of the most serious public health problems and has led to a global epidemic. Obesity is one of the greatest risk factors of obstructive sleep apnea (OSA), which is found in 60 to 70% of obese patients mainly due to the buildup of fat tissue in the upper portion of the thorax and neck. The aim of the present randomized clinical trial is to assess daytime sleepiness, sleep architecture and pulmonary function in patients with severe obesity before and after bariatric surgery. Read More

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http://dx.doi.org/10.1186/2049-6958-9-43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135715PMC
August 2014
24 Reads

[Results of total laryngectomy as treatment for locally advanced laryngeal cancer in the organ-preservation era].

Acta Otorrinolaringol Esp 2015 May-Jun;66(3):132-8. Epub 2014 Aug 4.

Servicio de Otorrinolaringología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España; Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, España.

Introduction And Objectives: Total laryngectomy (TL) and postoperative radiotherapy (RT), when indicated, have proven to be effective in treating cases of locally advanced laryngeal cancer. The aim of this study was to analyse the oncological outcomes of this procedure in patients with laryngeal cancer classified T3 and T4a.

Methods: We studied 80 patients (51 T3 and 29 T4a) with primary squamous cell carcinoma of the larynx who underwent TL between 1998 and 2006. Read More

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http://dx.doi.org/10.1016/j.otorri.2014.06.001DOI Listing
December 2016
10 Reads

Role of concomitant chemoradiation in locally advanced head and neck cancers.

Asian Pac J Cancer Prev 2014 ;15(10):4147-52

Department of Otorhinolaryngology and Head and Neck Surgery, Father Muller Medical College, Mangalore, India E-mail :

Standard therapy for advanced head and neck cancer consists of a combination of surgery and radiation. However, survival of this patient population has not improved during the past 20 years. Many different multimodality treatment schedules have been proposed, and chemotherapy is often used with the intent of organ preservation. Read More

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May 2015
2 Reads

Should elective neck dissection be routinely performed in patients undergoing salvage total laryngectomy?

J Laryngol Otol 2014 Mar 17;128(3):279-83. Epub 2014 Mar 17.

Department of Otorhinolaryngology Head and Neck Surgery, Guy's and St. Thomas' NHS Foundation Trust, London, UK.

Background: The prevalence of occult neck metastasis in patients undergoing salvage total laryngectomy remains unclear, and there is controversy regarding whether elective neck dissection should routinely be performed.

Method: A retrospective case note review of 32 consecutive patients undergoing salvage total laryngectomy in a tertiary centre was performed, in order to correlate pre-operative radiological staging with histopathological staging.

Results: The median patient age was 61 years (range, 43-84 years). Read More

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http://search.proquest.com/openview/bd80bf1003b09a229044cab3
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http://www.journals.cambridge.org/abstract_S0022215114000425
Publisher Site
http://dx.doi.org/10.1017/S0022215114000425DOI Listing
March 2014
3 Reads

Number of tumor foci as predictor of lateral lymph node metastasis in papillary thyroid carcinoma.

Head Neck 2015 May 10;37(5):650-4. Epub 2014 Apr 10.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.

Background: The purpose of this study was to determine the clinicopathologic characteristics of patients with papillary thyroid carcinoma (PTC) by the number of tumor foci.

Methods: A retrospective analysis of 2095 patients with PTC was performed. The study population was divided into 4 groups based on the number of tumor foci: N1 (1 tumor focus), N2 (2 foci), N3 (3 foci), and N4 (4 or more foci). Read More

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http://dx.doi.org/10.1002/hed.23650DOI Listing
May 2015
6 Reads

Refining risk stratification for locoregional failure after chemoradiotherapy in human papillomavirus-associated oropharyngeal cancer.

Oral Oncol 2014 May 22;50(5):513-9. Epub 2014 Feb 22.

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States. Electronic address:

Background: To determine whether the addition of molecular and imaging biomarkers to established clinical risk factors could help predict locoregional failure (LRF) after chemoradiation in human papillomavirus (HPV)-related (+) oropharyngeal cancer (OPC) and improve patient selection for locoregional treatment de-intensification.

Methods: HPV status was determined for 198 consecutive patients with stage III/IV OPC treated with definitive chemoradiation from 5/2003 to 10/2010. The impact of pre-therapy epidermal growth factor receptor (EGFR) overexpression; imaging biomarkers including primary tumor and nodal maximum standardized uptake values on FDG-PET, gross tumor volumes, and matted nodes; and clinical factors on LRF (including residual disease at adjuvant neck dissection) was assessed. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2014.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086868PMC
May 2014
11 Reads

Lymph node ratio for postoperative staging of laryngeal squamous cell carcinoma with lymph node metastasis.

PLoS One 2014 27;9(1):e87037. Epub 2014 Jan 27.

Department of Head & Neck Surgery, Cancer Hospital, Fudan University, Shanghai, China ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Background: Lymph node metastasis has a significant impact on laryngeal cancer prognosis. The role of lymph node ratio (LNR, ratio of metastatic to examined nodes) in the staging of laryngeal cancer was not reported.

Patients And Methods: Records of laryngeal cancer patients with lymph node involvement from Surveillance, Epidemiology, and End Results database (SEER, training set, N = 1963) and Fudan University Shanghai Cancer Center (FDSCC, validating set, N = 27) were analyzed for the prognostic value of LNR. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087037PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903600PMC
September 2014
8 Reads

Outcomes after primary chemoradiotherapy for N3 (>6 cm) head and neck squamous cell carcinoma after an FDG-PET--guided neck management policy.

Head Neck 2014 Aug 19;36(8):1200-6. Epub 2013 Oct 19.

Princess Alexandra Hospital, Head and Neck Radiation Oncology Cancer Service, Brisbane, Queensland, Australia; University of Queensland, St. Lucia, Queensland, Australia.

Background: The purpose of this study was to assess whether a positron emission tomography (PET)-directed policy remains appropriate for managing neck nodes (N3; >6 cm) in head and neck squamous cell carcinoma (HNSCC).

Methods: All patients with N3 (>6 cm) HNSCC treated with definitive chemoradiotherapy (CRT) at our institution between 2005 and 2012 were included in the analysis. Patients underwent PET assessment before and 12 weeks after CRT. Read More

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http://dx.doi.org/10.1002/hed.23434DOI Listing
August 2014
4 Reads

Outcomes following chemoradiotherapy for N3 head and neck squamous cell carcinoma without a planned neck dissection.

Oral Oncol 2013 Jan 1;49(1):55-9. Epub 2012 Aug 1.

Department of Clinical Oncology, St. James's Institute of Oncology, Beckett Street, Leeds LS9 7TF, United Kingdom.

Objectives: The optimal management of the N3 neck in head and neck squamous cell carcinoma (HNSCC) remains controversial. We report the outcomes of patients with N3 disease treated with a strategy of concurrent chemo-radiotherapy (CRT)±induction chemotherapy (ICT) without a planned neck dissection.

Materials And Methods: Forty patients with HNSCC N3 disease treated between January 2004 and December 2010 were retrospectively identified. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2012.07.010DOI Listing
January 2013
13 Reads

Squamous cell carcinoma metastatic to cervical lymph nodes from unknown primary origin: the impact of chemoradiotherapy.

Chin J Cancer 2012 Oct 6;31(10):484-90. Epub 2012 Jun 6.

Northampton General Hospital, Northampton NN1 5BD, UK.

The management of cervical lymph node metastases of squamous cell carcinoma from an unknown primary site is still a therapeutic challenge. We report here our experience in treating these patients with chemoradiotherapy as a curative approach. Data from 40 patients were reviewed. Read More

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http://dx.doi.org/10.5732/cjc.012.10035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777450PMC
October 2012
2 Reads

Cancer of unknown primary: does treatment modality make a difference?

Laryngoscope 2012 Jun 26;122(6):1279-82. Epub 2012 Apr 26.

Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.

Objectives/hypothesis: We systematically reviewed the published experience on the treatment outcomes of patients with head and neck cancer of unknown primary (CUP) to determine if treatment modality affects survival outcomes.

Study Design: Meta-analysis.

Methods: A comprehensive literature search was performed for articles reporting survival outcomes for CUP in the head and neck published within the last 12 years. Read More

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http://dx.doi.org/10.1002/lary.22424DOI Listing
June 2012
11 Reads

[Long term results of partial laryngectomies in patients suffering from laryngeal cancer].

Otolaryngol Pol 2012 Jan-Feb;66(1):46-50

Katedra i Oddział Kliniczny Laryngologii w Zabrzu Śląskiego Uniwersytetu Medycznego w Katowicach.

Aim: The aim of the study was to evaluate the results of partial laryngectomies in patients with laryngeal cancer treated in the 2(nd) Clinical Department of Laryngology SUM in Zabrze in the years 1990-2000.

Materials And Methods: Retrospective clinical material includes 209 patients in whom surgery was a primary treatment method. No distant metastases (M1) or another malignant cancer were found. Read More

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http://dx.doi.org/10.1016/S0030-6657(12)70749-7DOI Listing
May 2012
5 Reads

Radio(chemo)therapy in the management of squamous cell carcinoma of cervical lymph nodes from an unknown primary site. A retrospective analysis.

Strahlenther Onkol 2012 Jan 23;188(1):56-61. Epub 2011 Dec 23.

Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany,

Purpose: The goal was to retrospectively review the outcome of patients with cervical lymph node metastases of squamuos cell carcinoma of unknown primary site (CUP) treated with radio(chemo)therapy.

Patients And Methods: A total of 65 patients with CUP N1-3, M0, treated between 1988 and 2009 were evaluated: 61 patients underwent surgical resection followed by postoperative radio(chemo)therapy, 4 patients received definitive radiochemotherapy. Radiotherapy of bilateral neck nodes + the parapharyngeal region (COMP-RT) was performed in 48 patients (80%) and a unilateral radiotherapy of lymph nodes (UL-RT) in 17 patients (20%). Read More

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http://dx.doi.org/10.1007/s00066-011-0017-8DOI Listing
January 2012
3 Reads

Management of the "violated neck" in the era of chemoradiation.

Laryngoscope 2011 Nov 12;121(11):2349-58. Epub 2011 Oct 12.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.

Objectives: To determine if patients who have undergone an open neck biopsy (a "violated" neck) have improved disease control and survival with completion neck dissection.

Materials And Methods: Retrospective review of patients who underwent open cervical biopsy for diagnosis prior to definitive treatment between February 1997 and February 2010 at two academic tertiary referral centers.

Results: Ninety-four patients met study criteria, with completion neck dissection performed in 53 patients (56%). Read More

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http://dx.doi.org/10.1002/lary.22186DOI Listing
November 2011
2 Reads

Salvage laryngectomy: oncological and functional outcome.

Oral Oncol 2011 Apr 26;47(4):296-301. Epub 2011 Feb 26.

Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, P.O. Box 7057, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

The purpose of the research was to evaluate postoperative complications, functional outcome and survival after salvage laryngectomy. Second, to evaluate the management of the neck in combination with a laryngectomy in this group of patients. A retrospective analysis of all patients who underwent total laryngectomy for residual or recurrent squamous cell laryngeal carcinoma after (chemo)radiotherapy between November 1990 and June 2007 was performed. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2011.02.002DOI Listing
April 2011
2 Reads

The role of computed tomography in the management of the neck after chemoradiotherapy in patients with head-and-neck cancer.

Int J Radiat Oncol Biol Phys 2012 Feb 9;82(2):567-73. Epub 2011 Feb 9.

Department of Radiation Oncology, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.

Purpose: The aim of this study was to describe the outcome in patients with head-and neck-squamous cell carcinoma (HNSCC) followed up without neck dissection (ND) after concomitant chemoradiotherapy (CRT) based on computed tomography (CT) response. The second objective was to establish CT characteristics that can predict which patients can safely avoid ND.

Methods And Materials: Between 1998 and 2007, 369 patients with node-positive HNSCC were treated with primary CRT at our institution. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2010.11.066DOI Listing
February 2012
12 Reads

Relationship between radiation treatment time and overall survival after induction chemotherapy for locally advanced head-and-neck carcinoma: a subset analysis of TAX 324.

Int J Radiat Oncol Biol Phys 2011 Dec 6;81(5):e813-8. Epub 2011 Feb 6.

Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA 02115, USA.

Purpose: To analyze the relationship between overall survival (OS) and radiation treatment time (RTT) and overall treatment time (OTT) in a well-described sequential therapy paradigm for locally advanced head-and-neck carcinoma (LAHNC).

Methods And Materials: TAX 324 is a Phase III study comparing TPF (docetaxel, cisplatin, and fluorouracil) with PF (cisplatin and fluorouracil) induction chemotherapy (IC) in LAHNC patients; both arms were followed by carboplatin-based chemoradiotherapy (CRT). Prospective radiotherapy quality assurance was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016100366
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http://dx.doi.org/10.1016/j.ijrobp.2010.12.005DOI Listing
December 2011
3 Reads

When to address level I lymph nodes in neck dissections?

Otolaryngol Head Neck Surg 2010 Mar;142(3):355-8

Department of Otolaryngology-Head and Neck Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Comprehensive Cancer Center, the Ohio State University, Columbus, OH, USA.

Objective: To investigate the involvement of level I neck lymph node groups in head and neck carcinoma and compare the effect of primary tumor sites, such as oral cavity (OC), oropharynx (OP), hypopharynx (HP), and larynx (Lx), on level I lymph node metastasis.

Study Design: Case series with chart review.

Setting: Comprehensive Cancer Center. Read More

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http://journals.sagepub.com/doi/10.1016/j.otohns.2009.11.033
Publisher Site
http://dx.doi.org/10.1016/j.otohns.2009.11.033DOI Listing
March 2010
11 Reads

Propofol-induced sleep: polysomnographic evaluation of patients with obstructive sleep apnea and controls.

Otolaryngol Head Neck Surg 2010 Feb;142(2):218-24

Discipline of Otorhinolaryngology, University of São Paulo, São Paulo, Brazil.

Objective: The localization of upper airway obstruction in patients with obstructive sleep apnea (OSA) may optimize treatment. Nasoendoscopy during propofol sedation allows such an evaluation, but the effect of this drug on respiratory patterns and muscle relaxation is unknown. The objective of the present study was to determine through polysomnography whether propofol would change sleep parameters. Read More

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http://dx.doi.org/10.1016/j.otohns.2009.11.002DOI Listing
February 2010
8 Reads

Study of the length of hospital stay for free flap reconstruction of oral and pharyngeal cancer in the context of the new French casemix-based funding.

Oral Oncol 2010 Mar 8;46(3):190-4. Epub 2010 Jan 8.

Head and Neck Oncologic Surgery Unit, Institut Curie, 26 rue d'Ulm, 75005 Paris, France.

The French national health insurance reimbursement system has recently changed from a global hospital funding system to casemix-based funding. The authors studied the factors likely to influence the length of hospital stay for free flap reconstructions after surgery for cancers of the oral cavity or pharynx. Data concerning 207 oral cavity or pharynx free flap reconstructions were extracted from a prospective registration. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2009.12.002DOI Listing
March 2010
14 Reads

Docetaxel, ifosfamide and cisplatin (DIP) in squamous cell carcinoma of the head and neck.

Anticancer Res 2009 Dec;29(12):5137-42

Antwerp University Hospital, Department of Medical Oncology, Wilrijkstraat 10, 2650 Edegem, Belgium.

Background: Docetaxel, ifosfamide and cisplatin have all shown activity in squamous cell carcinoma of the head and neck (SCCHN). The optimal combination of the three drugs is, however, unknown. Considering the favorable results of taxane-containing triplets as induction chemotherapy in locally advanced (LA) SCCHN, DIP (docetaxel, ifosfamide, cisplatin) was studied in this setting as part of a phase I dose- and sequence-exploring study. Read More

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December 2009
5 Reads

Squamous cell carcinoma metastatic to cervical lymph nodes from an unknown primary site: the impact of radiotherapy.

Tumori 2009 Mar-Apr;95(2):185-90

Department of Radiation Oncology, Second Affiliated Hospital of Soochow University, Suzhou, China.

Aims And Background: Cervical lymph node metastases of squamous cell carcinoma from an unknown primary site constitute about 5% of the total head and neck cancer, cases. The management of these patients is still a therapeutic challenge. The aim of the present study was to analyze the prognosis in a series of patients and, in particular, the impact of different radiotherapy techniques on the prognosis. Read More

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July 2009
6 Reads