333 results match your criteria Management of the N0 Neck


Clinico-radiological Co-relation of Carcinoma Larynx and Hypopharynx: A Prospective Study.

Indian J Otolaryngol Head Neck Surg 2019 Mar 22;71(1):22-28. Epub 2017 Jul 22.

Department of Otorhinolaryngology, Government Medical College, Kozhikode, Kerala 673008 India.

The successful management of laryngeal and hypopharyngeal cancers requires accurate diagnosis, staging, assessment of patient wishes, and the selection of the most appropriate treatment for the individual patient. Imaging plays an important complementary role to clinical examination and endoscopy in the evaluation of laryngeal and hypopharyngeal cancers. The combined information allows the disease to be staged accurately. Read More

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http://link.springer.com/10.1007/s12070-017-1175-5
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http://dx.doi.org/10.1007/s12070-017-1175-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401033PMC
March 2019
2 Reads

Neck dissection for salivary gland malignancies.

Oper Tech Otolayngol Head Neck Surg 2018 Sep 3;29(3):157-161. Epub 2018 Jul 3.

Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065.

Salivary gland carcinomas are diverse, and their biological behavior and surgical management are also variable and somewhat controversial. Cervical lymph node status is an important prognostic variable for salivary gland malignancies. Neck dissection should be undertaken if there is clinical or radiographic evidence of associated nodal metastasis in the neck. Read More

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http://dx.doi.org/10.1016/j.otot.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405234PMC
September 2018
1 Read

Management of clinically N0 neck in oropharyngeal carcinoma.

Eur Arch Otorhinolaryngol 2019 Apr 7;276(4):1205-1210. Epub 2019 Feb 7.

Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, P.O. Box 263, 00029 HUS, Helsinki, Finland.

Purpose: Only a minority of patients with oropharyngeal squamous cell carcinoma (OPSCC) are diagnosed without regional metastasis (cN0). Studies focusing on the management of cN0 neck in OPSCC are scarce.

Methods: We reviewed all OPSCC patients treated at our institution with cN0 neck between 2000 and 2009. Read More

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http://link.springer.com/10.1007/s00405-019-05314-x
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http://dx.doi.org/10.1007/s00405-019-05314-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426801PMC
April 2019
3 Reads

Controversies in relation to neck management in N0 early oral tongue cancer.

Jpn J Clin Oncol 2019 Apr;49(4):297-305

Department of Head and Neck Surgery, National Cancer Center Hospital East, Chiba, Japan.

The standard local treatment for early-stage tongue cancer with no clinical lymph node metastases is partial glossectomy. The frequency of occult lymph node metastasis is ~20-30%. Thus, whether prophylactic neck dissection with glossectomy or glossectomy alone should be performed has been a controversial issue since the 1980s. Read More

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http://dx.doi.org/10.1093/jjco/hyy196DOI Listing
April 2019
1 Read

Impact of lymph node sampling on survival in cN0 major salivary gland adenoid cystic carcinoma.

Head Neck 2019 Jan 8. Epub 2019 Jan 8.

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.

Background: The role of elective neck dissection in the management of major salivary gland adenoid cystic carcinoma is unclear.

Methods: Data were retrospectively extracted from the National Cancer Center Database. The study cohort included 1504 patients with adenoid cystic carcinoma of major salivary glands with clinical N0 necks who were treated with surgery between 2004 and 2014. Read More

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http://dx.doi.org/10.1002/hed.25628DOI Listing
January 2019
2 Reads

Association of neck dissection with survival for early stage N0 tongue cancer: A SEER population-based study.

Authors:
Yufei Xie Gang Shen

Medicine (Baltimore) 2018 Dec;97(51):e13633

Department of Orthodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology.

The management of the node negative neck in patients with tongue cancer remains a complex and controversial issue, especially in those with early stage tumors. Patients with negative cervical lymph nodes generally have a good prognosis. However, in patients without neck dissection, neck recurrences may occur after excision of the primary tumor due to occult cervical metastases. Read More

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http://dx.doi.org/10.1097/MD.0000000000013633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320122PMC
December 2018

Management of N0 neck in early oral squamous cell carcinoma: A systematic review and meta-analysis.

Laryngoscope 2018 Dec 20. Epub 2018 Dec 20.

Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center, Boston, Massachusetts, U.S.A.

Objective: The role of elective neck dissection (END) in patients with stage I (T1N0) and II (T2N0) squamous cell carcinoma of the oral cavity remains a controversial topic. We investigate the need for END by establishing a true incidence of occult nodal disease as a function of T stage DATA SOURCES: MEDLINE, Google Scholar, Scopus.

Review Methods: Studies were selected using a set of inclusion and exclusion criteria. Read More

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http://dx.doi.org/10.1002/lary.27627DOI Listing
December 2018
2 Reads

De-intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV-positive oropharyngeal carcinoma.

Cochrane Database Syst Rev 2018 12 14;12:CD012939. Epub 2018 Dec 14.

ENT Department, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK, CB2 0QQ.

Background: More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV). HPV-positive OPSCC patients are often younger and have significantly improved survival relative to HPV-negative patients. Read More

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http://dx.doi.org/10.1002/14651858.CD012939.pub2DOI Listing
December 2018
2 Reads

What Is the Role of Elective Neck Dissection in the Management of Patients With Buccal Squamous Cell Carcinoma and Clinically Negative Neck?

J Oral Maxillofac Surg 2019 Mar 7;77(3):641-647. Epub 2018 Nov 7.

Associate Professor and Chair, Department of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI.

Purpose: Buccal squamous cell carcinoma (BSCC) is rare in the United States. Given its location, few anatomic barriers to spread exist and it has been found to have a high locoregional recurrence rate. The role of elective neck dissection (END) in patients with clinically negative neck (N0) is not clear. Read More

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http://dx.doi.org/10.1016/j.joms.2018.10.021DOI Listing
March 2019
7 Reads

Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial.

Lancet 2019 01 15;393(10166):40-50. Epub 2018 Nov 15.

Department of Radiation Oncology, Stanford University, Stanford, CA, USA.

Background: Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma have high survival when treated with radiotherapy plus cisplatin. Whether replacement of cisplatin with cetuximab-an antibody against the epidermal growth factor receptor-can preserve high survival and reduce treatment toxicity is unknown. We investigated whether cetuximab would maintain a high proportion of patient survival and reduce acute and late toxicity. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32779-XDOI Listing
January 2019
15 Reads

Update 2018: 18F-FDG PET/CT and PET/MRI in Head and Neck Cancer.

Clin Nucl Med 2018 Dec;43(12):e439-e452

R.D.N. is a Nuclear Medicine Physician, Kaiser Permanente, Santa Clara, CA.

There are recent advances, namely, a standardized method for reporting therapy response (Hopkins criteria), a multicenter prospective cohort study with excellent negative predictive value of F-FDG PET/CT for N0 clinical neck, a phase III multicenter randomized controlled study establishing the value of a negative posttherapy F-FDG PET/CT for patient management, a phase II randomized controlled study demonstrating radiation dose reduction strategies for human papilloma virus-related disease, and Food and Drug Administration approval of nivolumab for treatment of recurrent head and neck squamous cell carcinoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002247DOI Listing
December 2018
12 Reads
3.931 Impact Factor

Melanoma & nuclear medicine: new insights & advances.

Melanoma Manag 2018 Jun 28;5(1):MMT06. Epub 2018 Jun 28.

Nuclear Medicine Section & Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Centre, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands.

The contribution of nuclear medicine to management of melanoma patients is increasing. In intermediate-thickness N0 melanomas, lymphoscintigraphy provides a roadmap for sentinel node biopsy. With the introduction of single-photon emission computed tomography images with integrated computed tomography (SPECT/CT), 3D anatomic environments for accurate surgical planning are now possible. Read More

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http://dx.doi.org/10.2217/mmt-2017-0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122522PMC
June 2018
15 Reads

Decreased gastrostomy tube incidence and weight loss after transoral robotic surgery for low- to intermediate-risk oropharyngeal squamous cell carcinoma.

Head Neck 2018 Nov 13;40(11):2507-2513. Epub 2018 Aug 13.

Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Functional outcomes after treatment for oropharyngeal squamous cell carcinoma (SCC) are increasingly prioritized. The purpose of this study was to investigate the incidence of gastrostomy tube placement and weight loss in patients with oropharyngeal SCC who may be eligible for either transoral robotic surgery (TORS) or nonsurgical management.

Methods: We conducted a retrospective review of previously untreated T1 to T2 and N0 to N2b oropharyngeal SCC to determine the rates of gastrostomy tube placement and weight loss according to Common Terminology Criteria for Adverse Events (CTCAE) criteria. Read More

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http://dx.doi.org/10.1002/hed.25382DOI Listing
November 2018
1 Read

Preoperative ultrasonography for tumor thickness evaluation in guiding management in patients with early oral tongue squamous cell carcinoma.

Indian J Radiol Imaging 2018 Apr-Jun;28(2):140-145

Department of Radiology, Amrita Institute of Medical Science, Kochi, Kerala, India.

Objectives: (1) To assess the statistical correlation between the tumor thickness (TT) by ultrasonography (USG) and microscopic measurement in cases of early oral tongue squamous cell carcinoma (OTSCC). (2) To assess the predictive capacity of TT by ultrasound in detecting nodal metastasis.

Materials And Methods: Prospective analysis was performed in 24 patients for a period of 2 years from 2012 to 2013. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_151_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038222PMC
July 2018
2 Reads

Survival benefits of adjuvant radiation in the management of early tongue cancer with depth of invasion as the indication.

Head Neck 2018 Oct 26;40(10):2263-2270. Epub 2018 Jun 26.

Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi-85, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Background: With the introduction of new American Joint Committee on Cancer (AJCC) classifications for head and neck cancers few cases are upgraded from T2 to T3 based only on depth of invasion. The role of adjuvant therapy in this particular subset of patients is still not defined.

Methods: This is a retrospective analysis of data from 2009 to 2015, of patients with histopathology of pT1, T2, and N0. Read More

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http://dx.doi.org/10.1002/hed.25329DOI Listing
October 2018
6 Reads
2.641 Impact Factor

Depth of invasion on pathological outcomes in clinical low-stage oral tongue cancer patients.

Oral Dis 2018 Oct 29;24(7):1198-1203. Epub 2018 May 29.

Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.

Objectives: Depth of invasion was added to the eighth edition American Joint Committee on Cancer guidelines for T staging of HPV-negative oral cavity squamous cell carcinoma. Our aim was to determine the impact of depth of invasion on pathological variables and outcomes in low-stage tongue cancer patients. We also examine the impact of tumor thickness and tumor clinical staging for comparison. Read More

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http://dx.doi.org/10.1111/odi.12887DOI Listing
October 2018
42 Reads

Impact of age on survival of locoregional nasopharyngeal carcinoma: An analysis of the Surveillance, Epidemiology, and End Results program database, 2004-2013.

Clin Otolaryngol 2018 10 4;43(5):1209-1218. Epub 2018 Jun 4.

Department of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.

Objectives: To determine the impact of age at diagnosis and other factors on survival in nasopharyngeal carcinoma (NPC).

Design, Setting And Participants: A retrospective, population-based cohort study of 3103 patients are selected, whose records were submitted to the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2013. We evaluated the demographic and clinical characteristics of patients who were 20 years or older with a diagnosis of primary, non-metastatic NPC. Read More

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http://dx.doi.org/10.1111/coa.13124DOI Listing
October 2018
3 Reads

Validation of the 8th edition of the AJCC/UICC TNM staging system for tongue squamous cell carcinoma.

Int J Clin Oncol 2018 Oct 19;23(5):844-850. Epub 2018 Apr 19.

Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.

Background: The revised 8th edition of the AJCC/UICC staging system was released in January 2017, and depth of invasion (DOI) was added to the new criteria for T classification in oral cavity cancer. In this study, we evaluated whether the 8th edition presents the prognosis and risk of nodal metastasis in patients with squamous cell carcinoma of tongue more accurately than did the 7th edition.

Methods: The data for 112 patients were obtained and reclassified based on the criteria presented in the 8th edition. Read More

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http://dx.doi.org/10.1007/s10147-018-1276-5DOI Listing
October 2018
4 Reads

Clinicopathological Factors of Cervical Nodal Metastasis and the Concept of Selective Lateral Neck Dissection in the Surgical Management of Carcinoma Larynx and Hypopharynx and Its Outcome.

Indian J Surg Oncol 2018 Mar 9;9(1):24-27. Epub 2017 May 9.

Department of Surgical Oncology, Regional Cancer Center, Thiruvanathapuram, India.

To study the clinicopathological and molecular factors which correlate with nodal metastasis in laryngeal and hypopharyngeal carcinoma, a retrospective analysis of 170 patients who underwent surgery for laryngeal and hypopharyngeal carcinoma at RCC, Trivandrum from 2006 to 2010 was done. The pathological nodal stage and levels of involvement were correlated with the clinicopathologic features of the primary disease. Neck node positivity was significantly more for lesions of pyriform sinus lesion (61%), with thyroid cartilage erosion (56%) and with base tongue involvement (88%). Read More

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http://dx.doi.org/10.1007/s13193-017-0666-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856687PMC
March 2018
8 Reads

Operable Oral Tongue Squamous Cell Cancer: 15 Years Experience at a Tertiary Care Center in North India.

Indian J Surg Oncol 2018 Mar 11;9(1):15-23. Epub 2017 May 11.

4Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 110029 India.

The aim of the present study was to provide insight into various demographic, clinical, and management profile of Indian patients with oral tongue squamous cell cancer (OTSCC). All the OTSCC patients who had undergone surgical treatment during 1995 to 2010 at a tertiary care center in North India were considered for the present study. The details of the patients were retrieved from a prospectively maintained computerized database. Read More

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http://link.springer.com/10.1007/s13193-017-0658-x
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http://dx.doi.org/10.1007/s13193-017-0658-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856685PMC
March 2018
10 Reads

A Clinical, Radiological, and Histopathological Correlation of Neck Nodes in Patients Undergoing Neck Dissection.

Int J Appl Basic Med Res 2018 Jan-Mar;8(1):9-13

Department of ENT and Head and Neck Surgery, SRMS IMS, Bareilly, Uttar Pradesh, India.

Objectives: Management of neck metastases in terms of diagnosis and treatment has always been a controversial issue in patients of head and neck malignancy. The main area of debate in case of diagnosis lies with the fact that whether we should rely on ultrasound, as a diagnostic modality for diagnosing micrometastases in the neck in head and neck malignancy patients? The second controversial issue is the management of N0 neck, whether to be radical or conservative?

Materials And Methods: This study was conducted on 70 diagnosed patients of head and neck carcinoma who were planned for resection of the primary. An appropriate neck dissection was performed in all the patients, and their clinical, ultrasonography, and postoperative histopathological neck findings were correlated. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_391_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846226PMC

Treatment of early stage Supraglottic squamous cell carcinoma: meta-analysis comparing primary surgery versus primary radiotherapy.

J Otolaryngol Head Neck Surg 2018 Mar 5;47(1):19. Epub 2018 Mar 5.

Department of Otolaryngology - Head & Neck Surgery, Schulich Medicine & Dentistry, London Health Sciences Centre, Western University, Victoria Hospital, London, ON, Canada.

Objectives: For early stage supraglottic squamous cell carcinoma (SCC), single modality treatment either in the form of primary organ preservation surgery alone or radiation alone is recommended. Thus, a definite treatment strategy for early stage supraglottic SCC remains undefined. The primary objective of this study was to conduct a systematic review and meta-analysis comparing the oncologic outcomes of surgery and radiotherapy in early stage (Stage I and II) T1 N0 and T2 N0 supraglottic SCC. Read More

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http://dx.doi.org/10.1186/s40463-018-0262-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839014PMC
March 2018
4 Reads

Tumor Infiltration Depth as a Prognostic Parameter for Nodal Metastasis in Oral Squamous Cell Carcinoma.

Int J Appl Basic Med Res 2017 Oct-Dec;7(4):252-257

Department of Oral and Maxillofacial Pathology, A.B. Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India.

Oral squamous cell carcinoma (OSCC) has locoregional evolution, with frequent neck involvement. Significant number of studies have been undertaken to assess the parameters for treatment of N0 neck patients with a high likelihood of harboring occult node metastases. Many studies have indicated tumor infiltration depth (or tumor thickness) as one of the most important criteria in determining the further management. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_66_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752811PMC
January 2018
33 Reads

Reconstruction of oral cavity defect using versatile buccinator myomucosal flaps in the treatment of cT2-3, N0 oral cavity squamous cell carcinoma: Feasibility, morbidity, and functional/oncological outcomes.

Oral Oncol 2017 12 9;75:95-99. Epub 2017 Nov 9.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Objectives: To evaluate the results of oral cavity reconstruction using various types of buccinator myomucosal flap (BMMF) for the treatment of cT2-3 oral cavity squamous cell carcinoma (OCSCC).

Materials And Methods: Twenty-two consecutive patients who underwent surgical management for OCSCC and reconstruction using various types of BMMF were enrolled. Surgical results, complications, speech/swallowing outcomes, and recurrence were evaluated. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2017.11.007DOI Listing
December 2017
6 Reads

The role of elective neck dissection in the treatment of maxillary sinus squamous cell carcinoma.

Laryngoscope 2018 08 29;128(8):1835-1841. Epub 2017 Nov 29.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, U.S.A.

Objective: This study is designed to analyze the survival benefits of elective neck dissection (END) in the treatment of squamous cell carcinoma of the maxillary sinus (MS-SCC) with clinically negative neck lymph nodes (N0) and no metastasis (M0).

Study Design: The aim of this study was to evaluate whether END improves survival in patients with MS-SCC.

Methods: This study is a population-based, concurrent retrospective database analysis of patients diagnosed with N0M0 MS-SCC from 2004 to 2013. Read More

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http://dx.doi.org/10.1002/lary.27009DOI Listing
August 2018
17 Reads

Diagnostic and prognostic value of 18F-FDG PET, CT, and MRI in perineural spread of head and neck malignancies.

Eur Radiol 2018 Apr 30;28(4):1761-1770. Epub 2017 Oct 30.

Département d'imagerie médicale, Institut Gustave-Roussy, 94805, Villejuif, France.

Objectives: We assessed whether quantitative imaging biomarkers derived from fluorodeoxyglucose-positron emission tomography (18F-FDG PET) could be extracted from perineural spread (PNS) in head and neck malignancies (HNM) to improve patient risk stratification.

Methods: A case-control exploratory study (1:2 ratio) enrolled 81 patients with FDG-avid HNM. The case-group comprised 28 patients with documented PNS (reference: expert consensus), including 14 squamous cell carcinomas (SCC). Read More

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http://dx.doi.org/10.1007/s00330-017-5063-xDOI Listing
April 2018
32 Reads

Efficacy of laryngectomy alone for treatment of locally advanced laryngeal cancer: A stage- and subsite-specific survival analysis.

Clin Otolaryngol 2018 04 21;43(2):544-552. Epub 2017 Nov 21.

Department of Otolaryngology, Division of Head and Neck Surgery, University of California Davis, Sacramento, CA, USA.

Objective: Total laryngectomy is a well-established treatment for locally advanced laryngeal cancer. Evidence for the benefit of post-operative radiotherapy after laryngectomy in patients with locally advanced primaries and N0 or N1 nodal disease is limited. This study aimed to determine whether total laryngectomy alone is adequate therapy for certain patient subgroups with locally advanced laryngeal cancer. Read More

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http://dx.doi.org/10.1111/coa.13018DOI Listing
April 2018
5 Reads

Metastatic Squamous Cell Carcinoma of the Lower Lip: Analysis of the 5-Year Survival Rate.

Arch Craniofac Surg 2017 Jun 26;18(2):105-111. Epub 2017 Jun 26.

Department of Plastic and Reconstructive Surgery, Centro Chirurgico San Paolo, Pistoia, Italy.

Objectives: The author analyse the impact of extracapsular lymph node spread and bone engagement in the ipsilateral neck of patients suffering squamous cell carcinoma (SCC) of the lower lip.

Methods: The data of 56 neck dissections performed in patients suffering SCC of the lower lip between January 2000 and December 2008 were retrospectively analysed. Statistical analysis was performed with the Kaplan-Meier life table method, and the survival rate was investigated with the log rank statistic and significance test. Read More

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http://dx.doi.org/10.7181/acfs.2017.18.2.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556890PMC
June 2017
17 Reads

Sentinel lymph node biopsy for oral squamous cell carcinoma. Where are we now?

Br J Oral Maxillofac Surg 2017 Oct 30;55(8):757-762. Epub 2017 Aug 30.

Department of Oral and Maxillofacial Surgery, University College London Hospital, 235 Euston Road, Fitzrovia, London NW1 2BU.

Recent data have confirmed that elective surgical management of the cN0 neck improves survival in patients with early (T1-T2) oral squamous cell carcinoma (SCC), and is better than watchful waiting. However, elective neck dissection (END) may not always be necessary. Sentinel node biopsy (SNB), which is a reliable staging test for patients with early disease and a radiologically N0 neck, can detect occult metastases with a sensitivity of 86%-94%. Read More

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http://dx.doi.org/10.1016/j.bjoms.2017.07.007DOI Listing
October 2017
21 Reads

[Management of T3 supraglottic carcinoma: a retrospective study].

Zhonghua Zhong Liu Za Zhi 2017 Aug;39(8):613-617

Department of Head and Neck Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

To discuss the strategy of therapeutic management of T3 supraglottic carcinoma. A retrospective analysis of 459 patients with T3 supraglottic carcinoma treated in our hospital was performed. We evaluated the results of different managements, including surgery alone, preoperative radiotherapy, postoperative radiotherapy and radiotherapy alone. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2017.08.010DOI Listing
August 2017
7 Reads

Site-specific gene expression patterns in oral cancer.

Head Face Med 2017 May 10;13(1). Epub 2017 May 10.

Department of Cranio- and Maxillofacial Surgery, Marienhospital Stuttgart, Stuttgart, Germany.

Background: Squamous cell carcinomas (SCCs) are the most prevalent malignant tumours within the head and neck. Evidence exists that distinct genes are differentially regulated in SCCs of the oral cavity compared to other head and neck regions. Given this background, the aim of this study was to investigate whether such tumour site-specific gene expression can also be observed in different localizations within the oral cavity. Read More

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http://dx.doi.org/10.1186/s13005-017-0138-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424406PMC
May 2017
24 Reads

Radiation therapy for oropharyngeal squamous cell carcinoma: Executive summary of an ASTRO Evidence-Based Clinical Practice Guideline.

Pract Radiat Oncol 2017 Jul - Aug;7(4):246-253. Epub 2017 Apr 17.

Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.

Purpose: To present evidence-based guidelines for the treatment of oropharyngeal squamous cell carcinoma (OPSCC) with definitive or adjuvant radiation therapy (RT).

Methods And Materials: The American Society for Radiation Oncology convened the OPSCC Guideline Panel to perform a systematic literature review investigating the following key questions: (1) When is it appropriate to add systemic therapy to definitive RT in the treatment of OPSCC? (2) When is it appropriate to deliver postoperative RT with and without systemic therapy following primary surgery for OPSCC? (3) When is it appropriate to use induction chemotherapy in the treatment of OPSCC? (4) What are the appropriate dose, fractionation, and volume regimens with and without systemic therapy in the treatment of OPSCC?

Results: Patients with stage IV and stage T3 N0-1 OPSCC treated with definitive RT should receive concurrent high-dose intermittent cisplatin. Patients receiving adjuvant RT following surgical resection for positive surgical margins or extracapsular extension should be treated with concurrent high-dose intermittent cisplatin, and individuals with these risk factors who are intolerant of cisplatin should not routinely receive adjuvant concurrent systemic therapy. Read More

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http://dx.doi.org/10.1016/j.prro.2017.02.002DOI Listing
March 2018
30 Reads

Management of Recurrent and Metastatic HPV-Positive Oropharyngeal Squamous Cell Carcinoma after Transoral Robotic Surgery.

Otolaryngol Head Neck Surg 2017 07 4;157(1):69-76. Epub 2017 Apr 4.

1 Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, USA.

Objective To describe management and oncologic outcomes for patients who develop locoregional recurrence (LRR) or distant metastasis (DM) following transoral robotic surgery for human papilloma virus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC). Study Design Case series with chart review. Setting Tertiary care referral center. Read More

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http://dx.doi.org/10.1177/0194599817696304DOI Listing
July 2017
19 Reads

Predictive Significance of Tumor Depth and Budding for Late Lymph Node Metastases in Patients with Clinical N0 Early Oral Tongue Carcinoma.

Head Neck Pathol 2017 Dec 3;11(4):477-486. Epub 2017 Apr 3.

Department of Otolaryngology Head and Neck Surgery, Yokohama City University, Yokohama, Kanagawa, Japan.

In clinical N0 early oral tongue carcinoma, treatment of occult lymph node metastasis is controversial. The purpose of this study was to assess the histopathological risk factors for predicting late lymph node metastasis in early oral tongue carcinoma. We retrospectively reviewed 48 patients with early oral tongue squamous cell carcinoma. Read More

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http://dx.doi.org/10.1007/s12105-017-0814-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677061PMC
December 2017
13 Reads

Features of papillary thyroid microcarcinoma associated with lateral cervical lymph node metastasis.

Clin Endocrinol (Oxf) 2017 Jun 30;86(6):845-851. Epub 2017 Mar 30.

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objectives: Papillary thyroid microcarcinoma (PTMC) has an excellent prognosis with an indolent disease course. However, some PTMCs have an aggressive course with lateral cervical lymph node (LCLN) metastasis or distant metastasis. This study aimed to evaluate the pre-operative features of PTMC associated with LCLN metastasis. Read More

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http://dx.doi.org/10.1111/cen.13322DOI Listing
June 2017
12 Reads

Management of the clinically node negative neck in squamous cell carcinoma of the maxilla.

Oral Oncol 2017 03 21;66:87-92. Epub 2017 Jan 21.

Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:

Objective: The management of the clinically node negative (N0) neck in patients with squamous cell carcinoma of the maxilla (MSCC) is a matter of debate. In this retrospective cohort study the incidence of occult metastases is determined in clinically N0 MSCCs, as well as histopathological factors associated with occult metastases.

Patients And Methods: 95 patients with clinically N0 MSCCs had maxillectomy. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2016.12.027DOI Listing
March 2017
13 Reads

Therapeutic Management of Pyriform Sinus Cancer.

Otolaryngol Head Neck Surg 2017 03 10;156(3):498-503. Epub 2017 Jan 10.

1 ENT and Head and Neck Surgery Department, University Hospital of Amiens, Amiens, France.

Objective To analyze the survival rate of a nonselected pyriform sinus cancer population. Study Design Case series with chart review. Setting University hospital. Read More

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http://dx.doi.org/10.1177/0194599816686335DOI Listing
March 2017
6 Reads

Management of the neck in early oral cancers: Is the verdict out?

J Cancer Res Ther 2016 Jul-Sep;12(3):1114-1116

Department of Surgical Oncology, St. John's Medical College, Bengaluru, Karnataka, India.

The management of patients with the clinically negative neck (N0) in early oral cancers awaits a clear mandate despite growing evidence favoring elective neck dissection. Having a general policy of operating all N0 neck may indeed increase the number of unnecessary neck dissection in the true pathological N0 necks, a more commonly encountered scenario. This controversy needs to be looked beyond statistical evidence to address a larger question to "does the neck truly harbor disease," thus, refining the early age old debate. Read More

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http://dx.doi.org/10.4103/0973-1482.164705DOI Listing
March 2017
9 Reads

Minimally invasive surgery versus radiotherapy/chemoradiotherapy for small-volume primary oropharyngeal carcinoma.

Cochrane Database Syst Rev 2016 12 11;12:CD010963. Epub 2016 Dec 11.

Head and Neck Unit, Royal Marsden Hospital, Fulham Road, London, UK, SW3 6JJ.

Background: More than 400,000 cases of oropharyngeal squamous cell carcinoma (OPSCC) are diagnosed each year worldwide and the incidence is rising, partly as a result of human papillomavirus. Human papillomavirus-associated OPSCC affects younger patients and often presents at a higher stage; however, it is associated with a better prognosis.Until recently, first-line management of OPSCC involved chemoradiotherapy, as research had demonstrated comparable survival outcomes when compared with open surgery, with significantly decreased morbidity. Read More

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http://dx.doi.org/10.1002/14651858.CD010963.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463943PMC
December 2016
64 Reads
2 Citations

Is it time to reconsider lobectomy in low-risk paediatric thyroid cancer?

Clin Endocrinol (Oxf) 2017 Apr 12;86(4):591-596. Epub 2017 Jan 12.

Division of Paediatric Endocrinology, Hospital for Sick Children, Toronto, Ontario, Canada.

Objective: Current guidelines recommend total thyroidectomy for nearly all children with well-differentiated thyroid cancer (WDTC). These guidelines, however, derive from older data accrued prior to current high-resolution imaging. We speculate that there is a subpopulation of children who may be adequately treated with lobectomy. Read More

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http://dx.doi.org/10.1111/cen.13287DOI Listing
April 2017
12 Reads

Sentinel Lymph Node Biopsy in N0 Neck for Squamous Cell Carcinoma of Oral Cavity: a Prospective Study.

Indian J Surg Oncol 2016 Dec 22;7(4):375-379. Epub 2016 Sep 22.

Department of Surgical Oncology, St Johns' Medical College, Bangalore, India.

Oral cancers in India are very common. SLNB (sentinel lymph node biopsy) for the management of the cN0 neck provides proper staging with less morbidity. The study aims at assessment of the technical feasibility and accuracy of SLNB. Read More

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http://dx.doi.org/10.1007/s13193-016-0560-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097774PMC
December 2016
8 Reads

Management of neck metastases in head and neck cancer: United Kingdom National Multidisciplinary Guidelines.

J Laryngol Otol 2016 May;130(S2):S161-S169

Department of Clinical Oncology,St James's Institute of Oncology,Leeds,UK.

This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. A rational plan to manage the neck is necessary for all head and neck primaries. With the emergence of new level 1 evidence across several domains of neck metastases, this guideline will identify the evidence-based recommendations for management. Read More

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http://dx.doi.org/10.1017/S002221511600058XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873907PMC
May 2016
19 Reads

Recurrent head and neck cancer: United Kingdom National Multidisciplinary Guidelines.

J Laryngol Otol 2016 May;130(S2):S181-S190

University Hospital Birmingham,UK.

This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. Recurrent cancers present some of the most challenging management issues in head and neck surgical and oncological practice. This is rendered even more complex by the poor evidence base to support management options, the substantial implications that treatments can have on the function and quality of life, and the difficult decision-making considerations for supportive care alone. Read More

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http://dx.doi.org/10.1017/S002221511600061XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873924PMC
May 2016
15 Reads

Non-melanoma skin cancer: United Kingdom National Multidisciplinary Guidelines.

J Laryngol Otol 2016 May;130(S2):S125-S132

Department of Otolaryngology-Head and Neck Surgery,Manchester Royal Infirmary,Oxford Road,Manchester,UK.

This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. This paper provides consensus recommendations on the management of cutaneous basal cell carcinoma and squamous cell carcinoma in the head and neck region on the basis of current evidence. Recommendations • Royal College of Pathologists minimum datasets for NMSC should be adhered to in order to improve patient care and help work-force planning in pathology departments. Read More

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http://dx.doi.org/10.1017/S0022215116000554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873942PMC
May 2016
9 Reads

Oropharyngeal cancer: United Kingdom National Multidisciplinary Guidelines.

J Laryngol Otol 2016 May;130(S2):S90-S96

Department of Cellular Pathology,The Newcastle upon Tyne Hospitals NHS Foundation Trust,Oral Health Research Group,Newcastle University,Newcastle upon Tyne,UK.

This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. There has been significant debate in the management of oropharyngeal cancer in the last decade, especially in light of the increased incidence, clarity on the role of the human papilloma virus in this disease and the treatment responsiveness of the human papilloma virus positive cancers. This paper discusses the evidence base pertaining to the management of oropharyngeal cancer and provides recommendations on management for this group of patients receiving cancer care. Read More

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http://dx.doi.org/10.1017/S0022215116000505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873902PMC
May 2016
6 Reads

Management of clinically negative nodes (N0) in supraglottic laryngeal carcinoma: A systematic review.

Authors:
Y H Liu Z W Du

Genet Mol Res 2016 Oct 17;15(4). Epub 2016 Oct 17.

Department of Otorhinolaryngology Head and Neck Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China.

The purpose of this study was to evaluate the treatment of clinically negative cervical lymph nodes in supraglottic carcinoma by a meta-analysis. The search words were "supraglottic carcinoma", "cervical lymph nodes negative/cN0", "radical neck dissection", and "radiotherapy". The databases included the Chinese biomedical literature database, Medline, Cochrane library, EMBASE database, journals, and theses, etc. Read More

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http://dx.doi.org/10.4238/gmr15048179DOI Listing
October 2016
8 Reads

Surgery in MEN 2A Patients Older Than 5 Years with Micro-MTC: Outcome at Long-term Follow-up.

Otolaryngol Head Neck Surg 2016 11 12;155(5):787-789. Epub 2016 Jul 12.

Department of Surgery and Translational Medicine, Medical School, and Regional Centre for Hereditary Endocrine Tumors, University of Florence, Florence, Italy.

In multiple endocrine neoplasia syndrome type 2A (MEN 2A), early total thyroidectomy (TT; performed before the age of 5 years) is the best option to prevent medullary thyroid carcinoma (MTC) development, but the management of MEN 2A patients diagnosed after childhood is still under debate. Seventeen consecutive patients diagnosed with MEN 2A after the age of 5 years (mean age, 23.3 years) with a pathologic diagnosis of micro-MTC without nodal involvement were enrolled. Read More

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http://dx.doi.org/10.1177/0194599816654856DOI Listing
November 2016
9 Reads

Sentinel node biopsy for oral cancer: A prospective multicenter Phase II trial.

Auris Nasus Larynx 2017 Jun 3;44(3):319-326. Epub 2016 Aug 3.

Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan. Electronic address:

Objective: A recent study identified a survival benefit with prophylactic neck dissection (ND) at the time of primary surgery as compared with watchful waiting followed by therapeutic neck dissection for nodal relapse, in patients with cN0 oral squamous cell carcinoma (OSCC). Alternative management of cN0 neck cancer is recommended to minimize the adverse effects of ND, indicating the need for sentinel node biopsy (SNB) and limited neck dissection. We conducted a multicenter Phase II study to examine the feasibility of SNB for clinically N0 OSCC. Read More

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http://dx.doi.org/10.1016/j.anl.2016.07.008DOI Listing
June 2017
12 Reads

Influence of previous treatment of oral squamous cell carcinoma on the geographic distribution of recurrent neck metastases: A case series of unusual level 4 metastases.

Am J Otolaryngol 2016 Sep-Oct;37(5):459-62. Epub 2016 Jul 12.

Thyroid, Head & Neck Cancer Foundation, New York, NY; Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Beth Israel, New York, NY.

Background: Cervical node management is vital for the successful treatment of oral squamous cell carcinoma (OSCC). Lymphatic spread from intra-oral malignancies usually follows a predictable path. We report on two patients with isolated level 4 recurrence following previous treatment for OSCC. Read More

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http://dx.doi.org/10.1016/j.amjoto.2016.07.002DOI Listing
March 2017
7 Reads

Elective Neck Dissection vs Observation in Early-Stage Squamous Cell Carcinoma of the Oral Tongue With No Clinically Apparent Lymph Node Metastasis in the Neck: A Systematic Review and Meta-analysis.

JAMA Otolaryngol Head Neck Surg 2016 09;142(9):857-65

Department of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv, Israel.

Importance: The elective management of no clinical or radiologic evidence of lymph node metastasis in the neck (cN0) in early stage T1-T2 oral tongue squamous cell carcinoma (OTSCC) has been the subject of much debate during the past 3 decades and continues to be controversial.

Objective: To systematically review the literature and carry out a meta-analysis of studies that compared elective neck dissection (END) with observation in patients with early-stage T1-T2 OTSCC and cN0 neck.

Data Sources: The MEDLINE, Scopus, Google scholar, and Cochrane databases were systematically searched for articles published between January 1, 1970, and June 1, 2015. Read More

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http://dx.doi.org/10.1001/jamaoto.2016.1281DOI Listing
September 2016
31 Reads