364 results match your criteria Management of the N0 Neck


Meta-analysis of risk of occult lymph node metastasis in the irradiated, clinically N0 neck.

Head Neck 2020 May 19. Epub 2020 May 19.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California, USA.

Background: Recurrent head and neck squamous cell carcinoma (HNSCC) after radiation is associated with poor survival, and management of the clinically negative (N0) neck during salvage surgery is controversial.

Methods: Studies were selected according to preferred reporting items for systematic reviews and meta-analyses guidelines. Inclusion criteria were patients with HNSCC, prior radiation to the lateral neck nodal basin, undergoing salvage surgery for local recurrence, persistence or second primary, and N0 at time of salvage. Read More

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http://dx.doi.org/10.1002/hed.26248DOI Listing

Sentinel lymph node biopsy in clinically node negative patients with papillary thyroid carcinoma.

J BUON 2020 Jan-Feb;25(1):376-382

Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.

Purpose: The incidence of histologically proven lymph node metastases (LNM) in papillary thyroid carcinoma (PTC) reaches 80%. According to different guidelines surgical management in clinically N0 (cN0) patients with PTC remains controversial. The purpose of this study was to investigate if sentinel lymph node biopsy (SLNb) using methylene blue dye is accurate in the detection of LNM in the lateral neck compartment in cN0 patients with PTC. Read More

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Transoral resection with buccinator flap reconstruction vs. pull-through resection and free flap reconstruction for the management of T1/T2 cancer of the tongue and floor of the mouth.

J Craniomaxillofac Surg 2020 May 24;48(5):514-520. Epub 2020 Feb 24.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.

Aim: To compare the most important techniques usually used in these patients.

Materials And Methods: A multicentric retrospective evaluation on patients treated for cT1/2 N0 OTFOM SCC was conducted; patients in group A were treated by transoral approach and miomucosal local flap while those in group B were treated by pull-through and free flap reconstruction. Oncologic, functional and quality of life evaluation was assessed. Read More

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http://dx.doi.org/10.1016/j.jcms.2020.02.010DOI Listing

Elective neck dissection for salvage total laryngectomy: A systematic review, meta-analysis and "decision-to-treat" approach.

Clin Otolaryngol 2020 Jul 7;45(4):558-573. Epub 2020 Apr 7.

Department of ENT Surgery, Poole Hospitals NHS Foundation Trust, Poole, UK.

Introduction: The authors provide an updated, systematic and comprehensive summary of the literature concerning management of the N0 neck in patients for whom primary irradiation for squamous cell carcinoma of the larynx has been unsuccessful and salvage surgery in the form of total laryngectomy (TL) advocated.

Methods: Bibliographic databases MEDLINE, Cochrane, PubMed and Embase were searched from inception to April 2019, with no language restrictions. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Read More

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http://dx.doi.org/10.1111/coa.13520DOI Listing

Neck nodal recurrence and survival of clinical T1-2 N0 oral squamous cell carcinoma in comparison of elective neck dissection versus observation: A meta-analysis.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Apr 5;129(4):296-310. Epub 2019 Nov 5.

Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:

Objective: The clinical management of patients with T1-2 oral squamous cell carcinoma (OSCC) and clinically node-negative neck (cN0) continues to be controversial. We performed a systematic review of the literature to assess the effect of elective neck dissection (END) and neck observation (OBS) on the prognosis of patients with cT1-2 N0 OSCC.

Study Design: PubMed, Embase, and Cochrane Library were searched for studies related to END and OBS in patients with cT1-2 N0 OSCC. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.10.012DOI Listing

Modified in-continuity resection is advantageous for prognosis and as a new surgical strategy for management of oral tongue cancer.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 May 14;129(5):453-460. Epub 2019 Oct 14.

Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: The aim of this study was to explore the application value of modified in-continuity resection compared with traditional in-continuity resection and discontinuous resection for patients with cT2 N0 M0 oral tongue squamous cell carcinoma.

Study Design: This was a retrospective cohort study. The predictor was surgical management. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.09.016DOI Listing

Sentinel lymph node biopsy with preoperative CT lymphography and intraoperative indocyanine green fluorescence imaging for N0 early tongue cancer: A long-term follow-up study.

J Craniomaxillofac Surg 2020 Mar 25;48(3):217-222. Epub 2020 Jan 25.

Department of Oral and Maxillofacial Surgery/Orthodontics, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.

Purpose: This study evaluated the usefulness of sentinel lymph node (SLN) biopsy with preoperative computed tomographic lymphography (CTL) and intraoperative indocyanine green (ICG) fluorescence imaging for N0 early tongue cancer.

Methods: Twenty-seven patients with N0 early oral tongue cancer underwent CTL with a 128-slice multi-detector row CT scanner to detect SLN on the day before resection of primary tumor and SLN biopsy under ICG fluorescence guidance. We identified the location and number of SLNs mapped by CTL and evaluated whether CTL-enhanced SLNs could be identified intraoperatively as ICG fluorescent lymph nodes. Read More

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http://dx.doi.org/10.1016/j.jcms.2020.01.007DOI Listing

Development and validation of a multivariable prediction model for the identification of occult lymph node metastasis in oral squamous cell carcinoma.

Head Neck 2020 Feb 14. Epub 2020 Feb 14.

Department of Otolaryngology - Head and Neck Surgery, Geneva University Hospital and Faculty of Medecine of the University of Geneva, Geneva, Switzerland.

Background: There have been few recent advances in the identification of occult lymph node metastases (OLNM) in oral squamous cell carcinoma (OSCC). This study aimed to develop, compare, and validate several machine learning models to predict OLNM in clinically N0 (cN0) OSCC.

Methods: The biomarkers CD31 and PROX1 were combined with relevant histological parameters and evaluated on a training cohort (n = 56) using four different state-of-the-art machine learning models. Read More

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http://dx.doi.org/10.1002/hed.26105DOI Listing
February 2020

Squamous Cell Carcinoma of a Thyroglossal Duct Cyst and the Role of a Level IA Neck Dissection.

ORL J Otorhinolaryngol Relat Spec 2020;82(3):163-167. Epub 2020 Feb 4.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA,

Squamous cell carcinoma of a thyroglossal duct cyst is exceedingly rare, with less than 30 cases reported across the literature. Herein, we present a case of squamous cell carcinoma (SCC) of a thyroglossal duct cyst (TGDC) and discuss the utility of a level IA neck dissection in these cases. In 2018, a 62-year-old female presented to a university-affiliated otolaryngologist with symptoms of dysphagia and a palpable anterior midline neck mass. Read More

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http://dx.doi.org/10.1159/000505374DOI Listing
February 2020

Management of the irradiated N0-neck during salvage pharyngo-laryngeal surgery.

Eur J Surg Oncol 2020 Jun 9;46(6):1059-1065. Epub 2020 Jan 9.

Department of Surgery, University Cancer Institute Toulouse - Oncopôle, University Hospital of Toulouse, Toulouse, France. Electronic address:

Background: Salvage surgeries are challenging procedures, with an associated poor prognosis. Management of the N0 neck in those situations remains controversial. We aim to compare oncologic outcomes regarding neck management after surgery for N0 pharyngo-laryngeal carcinoma occurring after loco-regional radiotherapy. Read More

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http://dx.doi.org/10.1016/j.ejso.2020.01.011DOI Listing

Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis.

Head Neck 2020 May 10;42(5):1057-1066. Epub 2020 Jan 10.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University Vienna, Vienna, Austria.

Sinonasal undifferentiated carcinomas (SNUCs), being an aggressive malignancy with dismal survival outcome, have given limited consideration regarding management of regional failures. A total of 12 studies, published between 1999 and 2019, met inclusion criteria. We performed a meta-analysis assessing regional (neck) relapse after elective neck treatment compared to observation in clinically node negative (N0) necks. Read More

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http://dx.doi.org/10.1002/hed.26077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217044PMC

High serum CCL18 predicts a poor prognosis in patients with laryngeal squamous cell carcinoma.

J Cancer 2019 17;10(27):6910-6914. Epub 2019 Nov 17.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China.

CCL18 is a cytokine secreted by M2 type tumor associated macrophages, which frequently over-expressed in diverse human cancers. However, the clinical significance of serum CCL18 in patients with laryngeal squamous cell carcinoma (LSCC) remains unknown. In this study, serum CCL18 was initially quantified by enzyme-linked immunosorbent assay (ELISA) in 146 patients with LSCC, 25 patients with precancerous lesions and 72 healthy volunteers. Read More

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http://dx.doi.org/10.7150/jca.37515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909940PMC
November 2019

Neck management in patients with olfactory neuroblastoma.

Oral Oncol 2020 02 10;101:104505. Epub 2019 Dec 10.

Department of Oncology, 920(th) Hospital of Joint Logistics Support Force, 212 Daguan Road, Kunming 650032, China. Electronic address:

Objective: Optimal neck management in patients with olfactory neuroblastoma (ONB), a rare malignancy, remains uncertain. This study aimed to analyse patterns of cervical lymph node metastases and corresponding clinical outcomes and to investigate the value of elective neck irradiation (ENI) in this population.

Methods And Materials: This study retrospectively reviewed clinical records, imaging findings, nodal metastasis features and treatment data of 217 patients with ONB treated at our hospital during 1991-2019. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.104505DOI Listing
February 2020
5 Reads
3.607 Impact Factor

Early tongue carcinomas (clinical stage I and II): echo-guided three-dimensional diode laser mini-invasive surgery with evaluation of histological prognostic parameters. A study of 85 cases with prolonged follow-up.

Lasers Med Sci 2020 Apr 13;35(3):751-758. Epub 2019 Dec 13.

Department of Interdisciplinary Medicine, University of Bari, Piazza G. Cesare, 11, 70124, Bari, Italy.

The management of patients with early stage (cT1-T2) tongue squamous cell carcinoma without clinicoradiologic evidence of neck node metastasis (cN0) has been widely debated over the last 3 decades and still remains controversial. Nevertheless, the identification of patients with low-stage tumours at high-risk for occult cervical metastases is imperative before planning treatments of primary tumours, as well as that of prognostic markers which may possibly select those patients who may benefit of additional workup after surgery in view of the high metastatic potential of the primary tumour. The pre-surgical evaluation of tongue malignant primary tumour (for assessing lateral and deep margins) along with diode laser surgery (with accurate incision, bleeding-free and with reduced/absent post-surgical complications) may lead to a more conservative but equally decisive surgical treatment, also with a greater patient compliance. Read More

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http://dx.doi.org/10.1007/s10103-019-02932-zDOI Listing

An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland.

Expert Rev Anticancer Ther 2019 10 8;19(10):899-908. Epub 2019 Oct 8.

Coordinator of the International Head and Neck Scientific Group , Padua , Italy.

: Management of clinically negative neck (cN0) in patients with parotid gland cancer is controversial. Treatment options can include observation, elective neck dissection or elective radiotherapy. : We addressed the treatment options for cN0 patients with parotid gland cancer. Read More

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http://dx.doi.org/10.1080/14737140.2019.1674143DOI Listing
October 2019
3 Reads
2.249 Impact Factor

Extensive lymphatic spread of papillary thyroid microcarcinoma is associated with an increase in expression of genes involved in epithelial-mesenchymal transition and cancer stem cell-like properties.

Cancer Med 2019 11 9;8(15):6528-6537. Epub 2019 Sep 9.

Department of Surgery, Yonsei University Health System, Seoul, Republic of Korea.

Background: Active surveillance is an alternative management for patents with low-risk papillary thyroid microcarcinoma (PTMC); however, there is an absence of specific molecular markers that predict its progression. We compared gene expression patterns between PTMC with lateral neck-node metastasis (N1b) and PTMC-lacking nodal metastasis (N0).

Methods: We performed oligonucleotide microarray analysis in three PTMCs without cervical lymph-node metastases (N0), and five PTMCs with lateral neck-node metastasis (N1b) at initial diagnosis, using an Illumina HumanHT-12 v4. Read More

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http://dx.doi.org/10.1002/cam4.2544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825983PMC
November 2019
1 Read

Preoperative Ultrasonographic Staging of Papillary Thyroid Carcinoma With the Eighth American Joint Committee on Cancer Tumor-Node-Metastasis Staging System.

Ultrasound Q 2020 Jun;36(2):158-163

Department of Ultrasound, Ruijin Hospital.

Objective: The purpose of this study was to evaluate the performance of preoperative ultrasonography (US) in the staging of papillary thyroid carcinoma (PTC) according to the eighth AJCC TNM classification system, to determine the effect of the preoperative US staging in the management of PTC.

Patients And Methods: Preoperative US was performed by 2 highly trained sonographers in 665 consecutive patients with PTC, and the T and N categories were determined preoperatively. The accuracy of preoperative US in clinical staging was evaluated based on the histopathological specimens according to the eighth AJCC TNM classification. Read More

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http://dx.doi.org/10.1097/RUQ.0000000000000469DOI Listing
June 2020
2 Reads

Current thinking in the management of adenoid cystic carcinoma of the head and neck.

Br J Oral Maxillofac Surg 2019 10 14;57(8):716-721. Epub 2019 Aug 14.

Department of Oral and Maxillofacial Surgery, Queen Victoria Hospital NHS Foundation Trust, Holtye Road, East Grinstead, RH19 3DZ. Electronic address:

Adenoid cystic carcinoma (ACC) is an aggressive, rare, malignant tumour that accounts for about 1% of all head and neck neoplasms and 10% of all salivary gland tumours. It is characterised by frequent local recurrences and distant metastases. Growth is slow but relentless, and progression poses a challenge to head and neck clinicians. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.07.021DOI Listing
October 2019
1 Read

Assessment of the prognostic value and N1b changes of the eighth TNM/AJCC staging system for differentiated thyroid carcinoma.

Int J Clin Oncol 2020 Jan 14;25(1):59-66. Epub 2019 Aug 14.

Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, West Huanhu Rd, Tianjin, 300060, People's Republic of China.

Background: The aim of this study was to evaluate the prognostic veracity for disease-specific survival (DSS) of the eighth edition of the American Joint Committee on Cancer/Union for International Cancer Control tumor-node-metastasis staging system (TNM-8) compared with the seventh edition (TNM-7) in a Chinese population of patients with differentiated thyroid carcinoma (DTC) and to evaluate the impact of N1b redefinition and reclassification on prediction of survival.

Methods: A total of 569 DTC patients who underwent thyroid surgery in two Chinese hospitals were included in analysis to assess the predictive accuracy and N1b changes of TNM-8. Data from the Surveillance, Epidemiology and End Results (SEER) program were applied to validate the findings on N1b changes of TNM-8. Read More

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http://dx.doi.org/10.1007/s10147-019-01522-xDOI Listing
January 2020
4 Reads

Cutaneous Squamous Cell Carcinoma Tumour Size is Associated with Sentinel Lymph Node Metastasis in a Cohort of 69 Patients.

Acta Derm Venereol 2019 Dec;99(13):1241-1245

Department of ENT-Head and Neck Surgery, University Cancer Institute Toulouse and Toulouse University Hospital, Hôpital Larrey, FR-31400 Toulouse, France.

Ten to fifty percent of high-risk cutaneous squamous cell carcinoma may potentially metastasize. However, the concept of sentinel lymph node biopsy remains controversial for cutaneous squamous cell carcinoma. The aim of this study was to identify prognostic factors associated with sentinel lymph node positivity. Read More

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http://www.medicaljournals.se/acta/content/abstract/10.2340/
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http://dx.doi.org/10.2340/00015555-3293DOI Listing
December 2019
4 Reads

Oncologic outcome of marginal mandibulectomy in squamous cell carcinoma of the lower gingiva.

BMC Cancer 2019 Aug 6;19(1):775. Epub 2019 Aug 6.

Department of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan Province, People's Republic of China.

Background: There is a large amount of controversy about the best management of the mandible in oral squamous cell carcinoma (SCC), mainly owing to the inability to acquire accurate bone invasion status. Therefore, our goal was to analyse the oncologic safety in patients undergoing marginal mandibulectomy (MM) for cT1-2 N0 SCC of the lower gingiva.

Methods: Patients undergoing MM for untreated cT1-2 N0 SCC of the lower gingiva were retrospectively enrolled. Read More

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http://dx.doi.org/10.1186/s12885-019-5999-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683491PMC
August 2019
3 Reads

Medullary Thyroid Cancer with Paraganglioma-Like Pattern Diagnosed During Pregnancy: A Case Report and Literature Revision.

Endocr Metab Immune Disord Drug Targets 2020 ;20(2):295-302

Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, University of Bari "Aldo Moro", Bari, Italy.

Introduction: Medullary thyroid carcinoma (MTC) is an infrequent thyroid malignancy rarely observed and managed during pregnancy. An accurate diagnostic workup is extremely important in this clinical setting to correctly diagnose and treat the disease, avoiding both maternal and fetal complications.

Objective: We report our experience in managing an MTC incidentally diagnosed during pregnancy in a 28-year female, highlighting critical aspects through the diagnostic workup. Read More

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http://dx.doi.org/10.2174/1871530319666190802142634DOI Listing
January 2020
5 Reads

Staging and Response Evaluation to Neo-Adjuvant Chemoradiation in Esophageal Cancers Using 18FDG PET/ CT with Standardized Protocol.

Asian Pac J Cancer Prev 2019 07 1;20(7):2003-2008. Epub 2019 Jul 1.

Dow Medical College, Dow University of Health Sciences (DUHS), Karachi, Pakistan.

Background: Precise staging of esophageal cancer (EC) is important for selection of optimal treatment option and prognostication. Aim of this study was to assess the role of 18FDG PET/CT in staging and response evaluation to neoadjuvant chemoradiation (nCR) in EC patients using standardized imaging protocol. Material and methods: This prospective study was conducted at PET/CT Section of Department of Radiology, Aga Khan University Hospital Karachi, Pakistan from July 2017 till February 2018. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.7.2003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745203PMC
July 2019
2 Reads
1.500 Impact Factor

Management of the N0 neck in patients with laryngeal squamous cell carcinoma.

Acta Otolaryngol 2019 Oct 25;139(10):908-912. Epub 2019 Jul 25.

Department of Otolaryngology, Eye and ENT Hospital, Fudan University , Shanghai , China.

Neck lymph node status is the chief prognostic index in patients with head and neck squamous cell carcinoma (SCC), yet the management of a clinically negative neck in this setting is still controversial, especially in patients with laryngeal SCC (LSCC). To evaluate the efficacy of selective neck dissection (SND) to control occult disease in patients with LSCC and clinically negative (cN0) necks. Medical records of 1476 patients with cN0 LSCC were analyzed. Read More

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http://dx.doi.org/10.1080/00016489.2019.1641219DOI Listing
October 2019
8 Reads

Descriptive Study of Nasopharyngeal Carcinoma and Treatment Outcomes: An Eight Years Experience in Hadhramout National Cancer Centre, Yemen.

Gulf J Oncolog 2019 May;1(30):61-66

Department of Surgical Specialties, Division of ENT, College of Medicine, Hadhramout University, Mukalla, Hadhramout Province, Yemen.

Objective: To describe the histological patterns, and to evaluate the long-term outcomes of non surgical treatment of nasopharyngeal carcinoma (NPC) in patients registered at Hadhramout National Cancer Centre (HNCC) in Mukalla City, in Hadhramout Province, Yemen.

Methods: Non-randomized descriptive cancer registrybased study of patients with different WHO types of nasopharyngeal cancer and different non surgical treatment modality. Data was obtained from the medical records of patients seen and followed-up at HNCC. Read More

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May 2019
3 Reads

Management of orbital invasion in esthesioneuroblastoma: 14 years' experience.

Radiat Oncol 2019 Jun 13;14(1):107. Epub 2019 Jun 13.

Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Xuhui, Shanghai, 200031, People's Republic of China.

Background: There is a scarcity of data about the prognostic value of orbital invasion in esthesioneuroblastoma (ENB), as well as about its management strategies. Indications for the preservation of orbital contents remain controversial, and the evaluation of orbital invasion has been ill defined.

Methods: This retrospective analysis contained 60 ENB patients with orbital invasion who underwent radiotherapy with or without surgery over the past 14 years. Read More

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http://dx.doi.org/10.1186/s13014-019-1313-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567903PMC
June 2019
7 Reads
2.546 Impact Factor

Occult contralateral nodal disease in oropharyngeal squamous cell carcinoma patients undergoing primary TORS with bilateral neck dissection.

Oral Oncol 2019 06 1;93:96-100. Epub 2019 May 1.

University of Toronto, Department of Otolaryngology - Head & Neck Surgery, Princess Margaret Cancer Center, 610 University Avenue, 3-955, Toronto, ON M5G 2M9, United States; Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada. Electronic address:

Background: Knowledge of the rate of occult contralateral nodal disease for oropharynx cancers (OPSCC) in the era of Human Papillomavirus-dominated disease would inform practitioners as to who may be a candidate for unilateral neck management. The objective of this study was to determine the rate of pathologic contralateral positive nodes in patients in OPSCC patients with pT1 and pT2 disease treated with TORS and bilateral neck dissections (BND).

Methods: Retrospective review of medical records was performed at Princess Margaret Cancer Center, Toronto; Icahn School of Medicine at Mount Sinai, New York City; and Montefiore Medical Center, New York City. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.04.017DOI Listing
June 2019
14 Reads

Sentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinoma.

J Surg Oncol 2019 Aug 16;120(2):101-108. Epub 2019 May 16.

Department of Head and Neck and Plastic Surgery, Erie County Medical Center, SUNY Buffalo, Buffalo, New York.

Background And Objectives: The management of the clinically N0 (cN0) neck is controversial for early stage squamous cell carcinoma of the oral cavity (OSCC). This paper represents a single institution series analyzing the efficacy of sentinel lymph node biopsy (SNB) for early stage oral cavity cancers.

Methods: From 2005 to 2017, 108 patients with cN0 OSCC were treated with primary resection and SNB. Read More

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http://dx.doi.org/10.1002/jso.25494DOI Listing
August 2019
11 Reads

Assessment of the Rate of Skip Metastasis to Neck Level IV in Patients With Clinically Node-Negative Neck Oral Cavity Squamous Cell Carcinoma: A Systematic Review and Meta-analysis.

JAMA Otolaryngol Head Neck Surg 2019 06;145(6):542-548

Department of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Importance: The rate of skip metastasis to neck level IV in patients with clinically node-negative neck (cN0) oral cavity squamous cell carcinoma (OCSCC) remains controversial.

Objective: To provide a high level of evidence using a meta-analysis on the rate of skip metastasis to level IV in this subset of patients.

Data Sources: The Embase, PubMed, and Google Scholar databases were searched for articles published during the period of January 1, 1970, through December 31, 2017, using the following key terms: neck dissection, N0 neck, squamous cell carcinoma, skip metastasis, radical neck dissection, lymph node management, neck metastasis, oral cavity cancer, and tongue cancer. Read More

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http://dx.doi.org/10.1001/jamaoto.2019.0784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512277PMC
June 2019
7 Reads

Clinico-radiological Co-relation of Carcinoma Larynx and Hypopharynx: A Prospective Study.

Indian J Otolaryngol Head Neck Surg 2019 Mar 22;71(1):22-28. Epub 2017 Jul 22.

Department of Otorhinolaryngology, Government Medical College, Kozhikode, Kerala 673008 India.

The successful management of laryngeal and hypopharyngeal cancers requires accurate diagnosis, staging, assessment of patient wishes, and the selection of the most appropriate treatment for the individual patient. Imaging plays an important complementary role to clinical examination and endoscopy in the evaluation of laryngeal and hypopharyngeal cancers. The combined information allows the disease to be staged accurately. Read More

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http://link.springer.com/10.1007/s12070-017-1175-5
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http://dx.doi.org/10.1007/s12070-017-1175-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401033PMC
March 2019
18 Reads

Neck dissection for salivary gland malignancies.

Oper Tech Otolayngol Head Neck Surg 2018 Sep 3;29(3):157-161. Epub 2018 Jul 3.

Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065.

Salivary gland carcinomas are diverse, and their biological behavior and surgical management are also variable and somewhat controversial. Cervical lymph node status is an important prognostic variable for salivary gland malignancies. Neck dissection should be undertaken if there is clinical or radiographic evidence of associated nodal metastasis in the neck. Read More

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http://dx.doi.org/10.1016/j.otot.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405234PMC
September 2018
7 Reads

Management of clinically N0 neck in oropharyngeal carcinoma.

Eur Arch Otorhinolaryngol 2019 Apr 7;276(4):1205-1210. Epub 2019 Feb 7.

Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, P.O. Box 263, 00029 HUS, Helsinki, Finland.

Purpose: Only a minority of patients with oropharyngeal squamous cell carcinoma (OPSCC) are diagnosed without regional metastasis (cN0). Studies focusing on the management of cN0 neck in OPSCC are scarce.

Methods: We reviewed all OPSCC patients treated at our institution with cN0 neck between 2000 and 2009. Read More

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http://link.springer.com/10.1007/s00405-019-05314-x
Publisher Site
http://dx.doi.org/10.1007/s00405-019-05314-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426801PMC
April 2019
8 Reads

Controversies in relation to neck management in N0 early oral tongue cancer.

Jpn J Clin Oncol 2019 Apr;49(4):297-305

Department of Head and Neck Surgery, National Cancer Center Hospital East, Chiba, Japan.

The standard local treatment for early-stage tongue cancer with no clinical lymph node metastases is partial glossectomy. The frequency of occult lymph node metastasis is ~20-30%. Thus, whether prophylactic neck dissection with glossectomy or glossectomy alone should be performed has been a controversial issue since the 1980s. Read More

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http://dx.doi.org/10.1093/jjco/hyy196DOI Listing
April 2019
6 Reads

Impact of lymph node sampling on survival in cN0 major salivary gland adenoid cystic carcinoma.

Head Neck 2019 06 8;41(6):1903-1907. Epub 2019 Jan 8.

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.

Background: The role of elective neck dissection in the management of major salivary gland adenoid cystic carcinoma is unclear.

Methods: Data were retrospectively extracted from the National Cancer Center Database. The study cohort included 1504 patients with adenoid cystic carcinoma of major salivary glands with clinical N0 necks who were treated with surgery between 2004 and 2014. Read More

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http://dx.doi.org/10.1002/hed.25628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202936PMC
June 2019
4 Reads

Association of neck dissection with survival for early stage N0 tongue cancer: A SEER population-based study.

Authors:
Yufei Xie Gang Shen

Medicine (Baltimore) 2018 Dec;97(51):e13633

Department of Orthodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology.

The management of the node negative neck in patients with tongue cancer remains a complex and controversial issue, especially in those with early stage tumors. Patients with negative cervical lymph nodes generally have a good prognosis. However, in patients without neck dissection, neck recurrences may occur after excision of the primary tumor due to occult cervical metastases. Read More

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http://dx.doi.org/10.1097/MD.0000000000013633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320122PMC
December 2018
6 Reads

Management of N0 neck in early oral squamous cell carcinoma: A systematic review and meta-analysis.

Laryngoscope 2019 08 20;129(8):E284-E298. Epub 2018 Dec 20.

Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center, Boston, Massachusetts, U.S.A.

Objective: The role of elective neck dissection (END) in patients with stage I (T1N0) and II (T2N0) squamous cell carcinoma of the oral cavity remains a controversial topic. We investigate the need for END by establishing a true incidence of occult nodal disease as a function of T stage DATA SOURCES: MEDLINE, Google Scholar, Scopus.

Review Methods: Studies were selected using a set of inclusion and exclusion criteria. Read More

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http://dx.doi.org/10.1002/lary.27627DOI Listing
August 2019
5 Reads

De-intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV-positive oropharyngeal carcinoma.

Cochrane Database Syst Rev 2018 12 14;12:CD012939. Epub 2018 Dec 14.

ENT Department, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK, CB2 0QQ.

Background: More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV). HPV-positive OPSCC patients are often younger and have significantly improved survival relative to HPV-negative patients. Read More

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http://dx.doi.org/10.1002/14651858.CD012939.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517188PMC
December 2018
5 Reads

What Is the Role of Elective Neck Dissection in the Management of Patients With Buccal Squamous Cell Carcinoma and Clinically Negative Neck?

J Oral Maxillofac Surg 2019 Mar 7;77(3):641-647. Epub 2018 Nov 7.

Associate Professor and Chair, Department of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI.

Purpose: Buccal squamous cell carcinoma (BSCC) is rare in the United States. Given its location, few anatomic barriers to spread exist and it has been found to have a high locoregional recurrence rate. The role of elective neck dissection (END) in patients with clinically negative neck (N0) is not clear. Read More

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http://dx.doi.org/10.1016/j.joms.2018.10.021DOI Listing
March 2019
23 Reads

Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial.

Lancet 2019 01 15;393(10166):40-50. Epub 2018 Nov 15.

Department of Radiation Oncology, Stanford University, Stanford, CA, USA.

Background: Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma have high survival when treated with radiotherapy plus cisplatin. Whether replacement of cisplatin with cetuximab-an antibody against the epidermal growth factor receptor-can preserve high survival and reduce treatment toxicity is unknown. We investigated whether cetuximab would maintain a high proportion of patient survival and reduce acute and late toxicity. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32779-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541928PMC
January 2019
48 Reads

Utilization of Transoral Robotic Surgery (TORS) in patients with Oropharyngeal Squamous Cell Carcinoma and its impact on survival and use of chemotherapy.

Oral Oncol 2018 11 15;86:75-80. Epub 2018 Sep 15.

Department of Radiation Oncology, Albert Einstein College of Medicine-Montefiore Medical Center, Bronx, NY, United States. Electronic address:

Objective: To determine whether patients with Oropharyngeal Squamous Cell Carcinoma (OPSCC) treated with Transoral Robotic Surgery (TORS) have similar survival to patients treated with definitive RT.

Materials And Methods: Using the National Cancer Database (NCDB) registry, we identified patients with newly diagnosed clinical T1-T2, N0-N2b OPSCC between 2010 and 2014. A multivariable logistic regression was utilized to determine the association between chemotherapy use and primary treatment modality (TORS vs definitive RT). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375183022
Publisher Site
http://dx.doi.org/10.1016/j.oraloncology.2018.06.009DOI Listing
November 2018
8 Reads

Update 2018: 18F-FDG PET/CT and PET/MRI in Head and Neck Cancer.

Clin Nucl Med 2018 Dec;43(12):e439-e452

R.D.N. is a Nuclear Medicine Physician, Kaiser Permanente, Santa Clara, CA.

There are recent advances, namely, a standardized method for reporting therapy response (Hopkins criteria), a multicenter prospective cohort study with excellent negative predictive value of F-FDG PET/CT for N0 clinical neck, a phase III multicenter randomized controlled study establishing the value of a negative posttherapy F-FDG PET/CT for patient management, a phase II randomized controlled study demonstrating radiation dose reduction strategies for human papilloma virus-related disease, and Food and Drug Administration approval of nivolumab for treatment of recurrent head and neck squamous cell carcinoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002247DOI Listing
December 2018
33 Reads
3.931 Impact Factor

Melanoma & nuclear medicine: new insights & advances.

Melanoma Manag 2018 Jun 28;5(1):MMT06. Epub 2018 Jun 28.

Nuclear Medicine Section & Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Centre, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands.

The contribution of nuclear medicine to management of melanoma patients is increasing. In intermediate-thickness N0 melanomas, lymphoscintigraphy provides a roadmap for sentinel node biopsy. With the introduction of single-photon emission computed tomography images with integrated computed tomography (SPECT/CT), 3D anatomic environments for accurate surgical planning are now possible. Read More

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http://dx.doi.org/10.2217/mmt-2017-0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122522PMC
June 2018
30 Reads

Decreased gastrostomy tube incidence and weight loss after transoral robotic surgery for low- to intermediate-risk oropharyngeal squamous cell carcinoma.

Head Neck 2018 11 13;40(11):2507-2513. Epub 2018 Aug 13.

Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Functional outcomes after treatment for oropharyngeal squamous cell carcinoma (SCC) are increasingly prioritized. The purpose of this study was to investigate the incidence of gastrostomy tube placement and weight loss in patients with oropharyngeal SCC who may be eligible for either transoral robotic surgery (TORS) or nonsurgical management.

Methods: We conducted a retrospective review of previously untreated T1 to T2 and N0 to N2b oropharyngeal SCC to determine the rates of gastrostomy tube placement and weight loss according to Common Terminology Criteria for Adverse Events (CTCAE) criteria. Read More

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http://dx.doi.org/10.1002/hed.25382DOI Listing
November 2018
8 Reads

Preoperative ultrasonography for tumor thickness evaluation in guiding management in patients with early oral tongue squamous cell carcinoma.

Indian J Radiol Imaging 2018 Apr-Jun;28(2):140-145

Department of Radiology, Amrita Institute of Medical Science, Kochi, Kerala, India.

Objectives: (1) To assess the statistical correlation between the tumor thickness (TT) by ultrasonography (USG) and microscopic measurement in cases of early oral tongue squamous cell carcinoma (OTSCC). (2) To assess the predictive capacity of TT by ultrasound in detecting nodal metastasis.

Materials And Methods: Prospective analysis was performed in 24 patients for a period of 2 years from 2012 to 2013. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_151_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038222PMC
July 2018
4 Reads

Survival benefits of adjuvant radiation in the management of early tongue cancer with depth of invasion as the indication.

Head Neck 2018 10 26;40(10):2263-2270. Epub 2018 Jun 26.

Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi-85, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Background: With the introduction of new American Joint Committee on Cancer (AJCC) classifications for head and neck cancers few cases are upgraded from T2 to T3 based only on depth of invasion. The role of adjuvant therapy in this particular subset of patients is still not defined.

Methods: This is a retrospective analysis of data from 2009 to 2015, of patients with histopathology of pT1, T2, and N0. Read More

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http://dx.doi.org/10.1002/hed.25329DOI Listing
October 2018
11 Reads
2.641 Impact Factor

Depth of invasion on pathological outcomes in clinical low-stage oral tongue cancer patients.

Oral Dis 2018 Oct 29;24(7):1198-1203. Epub 2018 May 29.

Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.

Objectives: Depth of invasion was added to the eighth edition American Joint Committee on Cancer guidelines for T staging of HPV-negative oral cavity squamous cell carcinoma. Our aim was to determine the impact of depth of invasion on pathological variables and outcomes in low-stage tongue cancer patients. We also examine the impact of tumor thickness and tumor clinical staging for comparison. Read More

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http://dx.doi.org/10.1111/odi.12887DOI Listing
October 2018
66 Reads

Impact of age on survival of locoregional nasopharyngeal carcinoma: An analysis of the Surveillance, Epidemiology, and End Results program database, 2004-2013.

Clin Otolaryngol 2018 10 4;43(5):1209-1218. Epub 2018 Jun 4.

Department of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.

Objectives: To determine the impact of age at diagnosis and other factors on survival in nasopharyngeal carcinoma (NPC).

Design, Setting And Participants: A retrospective, population-based cohort study of 3103 patients are selected, whose records were submitted to the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2013. We evaluated the demographic and clinical characteristics of patients who were 20 years or older with a diagnosis of primary, non-metastatic NPC. Read More

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http://dx.doi.org/10.1111/coa.13124DOI Listing
October 2018
6 Reads

Validation of the 8th edition of the AJCC/UICC TNM staging system for tongue squamous cell carcinoma.

Int J Clin Oncol 2018 Oct 19;23(5):844-850. Epub 2018 Apr 19.

Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.

Background: The revised 8th edition of the AJCC/UICC staging system was released in January 2017, and depth of invasion (DOI) was added to the new criteria for T classification in oral cavity cancer. In this study, we evaluated whether the 8th edition presents the prognosis and risk of nodal metastasis in patients with squamous cell carcinoma of tongue more accurately than did the 7th edition.

Methods: The data for 112 patients were obtained and reclassified based on the criteria presented in the 8th edition. Read More

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http://dx.doi.org/10.1007/s10147-018-1276-5DOI Listing
October 2018
8 Reads

Mature results of a prospective study of deintensified chemoradiotherapy for low-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma.

Cancer 2018 06 26;124(11):2347-2354. Epub 2018 Mar 26.

Department of Radiation Oncology, University of Florida Hospitals, Gainesville, Florida.

Background: The purpose of the current study was to determine quality of life and tumor control from a prospective phase 2 clinical trial evaluating deintensified chemoradiotherapy for favorable risk, human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma.

Methods: Patients with T0-T3, N0-N2c, M0, p16-positive disease and a minimal smoking history were treated with 60 grays of intensity-modulated radiotherapy with concurrent weekly intravenous cisplatin (30 mg/m ). The primary study endpoint was the pathologic complete response rate based on biopsy of the primary site and dissection of pretreatment positive lymph node regions. Read More

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http://doi.wiley.com/10.1002/cncr.31338
Publisher Site
http://dx.doi.org/10.1002/cncr.31338DOI Listing
June 2018
29 Reads

Clinicopathological Factors of Cervical Nodal Metastasis and the Concept of Selective Lateral Neck Dissection in the Surgical Management of Carcinoma Larynx and Hypopharynx and Its Outcome.

Indian J Surg Oncol 2018 Mar 9;9(1):24-27. Epub 2017 May 9.

Department of Surgical Oncology, Regional Cancer Center, Thiruvanathapuram, India.

To study the clinicopathological and molecular factors which correlate with nodal metastasis in laryngeal and hypopharyngeal carcinoma, a retrospective analysis of 170 patients who underwent surgery for laryngeal and hypopharyngeal carcinoma at RCC, Trivandrum from 2006 to 2010 was done. The pathological nodal stage and levels of involvement were correlated with the clinicopathologic features of the primary disease. Neck node positivity was significantly more for lesions of pyriform sinus lesion (61%), with thyroid cartilage erosion (56%) and with base tongue involvement (88%). Read More

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http://dx.doi.org/10.1007/s13193-017-0666-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856687PMC
March 2018
11 Reads