384 results match your criteria Management of the N0 Neck


The Role of Elective Neck Treatment in the Management of Sinonasal Carcinomas: A Systematic Review of the Literature and a Meta-Analysis.

Cancers (Basel) 2021 Apr 13;13(8). Epub 2021 Apr 13.

Department of Otorhinolaryngology, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.

The impact of elective neck treatment (ENT), whether by irradiation or dissection, on the prognosis of patients with cN0 sinonasal carcinomas (SNCs) remains an understudied issue. METHODS: A systematic review and meta-analysis of the literature were performed according to PRISMA guidelines in order to assess regional nodal relapse rate after ENT compared to observation in cN0 SNCs patients. Twenty-six articles for a total of 1178 clinically N0 patients were analyzed. Read More

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Research on neck dissection for oral squamous-cell carcinoma: a bibliometric analysis.

Int J Oral Sci 2021 04 1;13(1):13. Epub 2021 Apr 1.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Neck dissection for oral squamous-cell carcinoma (OSCC) is a clinically controversial issue and has therefore been the subject of abundant research. However, no one has performed a bibliometric study on this topic to date. The aim of this study was to assess the development of research on neck dissection for OSCC in terms of the historical evolution, current hotspots and future directions, particularly including research trends and frontiers from 2010 to 2019. Read More

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Life Expectancy and Treatment Patterns in Elderly Patients With Low-Risk Papillary Thyroid Cancer: A Population-Based Analysis.

Endocr Pract 2021 Mar 14;27(3):228-235. Epub 2020 Dec 14.

Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York. Electronic address:

Objective: Guidelines endorse active surveillance for low-risk papillary thyroid carcinoma (PTC), but this is not commonly utilized. Those with limited life expectancy due to age and comorbidity may be best suited for active surveillance given their higher likelihood of other-cause mortality compared to disease-specific mortality.

Methods: Surveillance, epidemiology, and end results-Medicare was queried for patients >65 years with T1, N0, M0 PTC who received surgery. Read More

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Improved survival after pancreatic re-resection of positive neck margin in pancreatic cancer patients. A systematic review and network meta-analysis.

Eur J Surg Oncol 2021 Jun 13;47(6):1258-1266. Epub 2021 Jan 13.

Vita Salute San Raffaele University Milan, Italy; Division of Pancreatic Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy.

The oncological benefit of achieving a negative pancreatic neck margin through re-resection after a positive frozen section (FS) is debated. Aim of this network meta-analysis is to evaluate the survival benefit of re-resection after intraoperative FS neck margin examination following pancreatectomy for ductal adenocarcinoma. A systematic search of studies comparing different strategies for the management of positive FS was performed. Read More

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High Expression of KLF10 Is Associated with Favorable Survival in Patients with Oral Squamous Cell Carcinoma.

Medicina (Kaunas) 2020 Dec 28;57(1). Epub 2020 Dec 28.

School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Background And Objectives: Krüppel-like transcription factor 10 (KLF10) plays a vital role in regulating cell proliferation, including the anti-proliferative process, activation of apoptosis, and differentiation control. KLF10 may also act as a protective factor against oral cancer. We studied the impact of KLF10 expression on the clinical outcomes of oral cancer patients to identify its role as a prognostic factor in oral cancer. Read More

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December 2020

Occult Nodal Metastasis in Oral Cavity Cancers.

Cureus 2020 Nov 23;12(11):e11640. Epub 2020 Nov 23.

Otolaryngology and Head and Neck Surgery, Aga Khan University Hospital, Karachi, PAK.

Introduction:  In squamous cell carcinoma (SCC) of the oral cavity, there is always a risk of occult metastasis to neck nodes in the clinically and radiologically negative neck (N0). Therefore, elective neck dissection (END) has ever been under discussion since the beginning of their routine use for the management of neck for oral carcinomas. The purpose of the current study is to identify the percentage of occult nodal metastasis to neck levels I-V in the cases of oral carcinoma who were treated for the N0 with END. Read More

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November 2020

Attempting to define sentinel node micrometastasis in oral squamous cell carcinoma.

Fukushima J Med Sci 2020 Dec 2;66(3):143-147. Epub 2020 Dec 2.

Department of Head and Neck Surgery and Otolaryngology, Asahi University Hospital.

Objective: The aim of this supplemental study of a sentinel node (SN) biopsy (SNB) trial for oral squamous cell carcinoma (OSCC) was to assess the effectiveness in identifying micrometastasis and determining whether elective neck dissection (END) is necessary.

Materials And Methods: Twenty-three patients with pathologically positive SNs were included. The sizes of the metastatic lesions in positive SNs (SMSNs) were classified and the rates of occult metastasis of non-SNs were compared. Read More

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December 2020

Predictive factors of cervical nodal metastases in N0 squamous cell carcinomas of the mobile tongue - A cohort study.

Ann Med Surg (Lond) 2020 Dec 10;60:403-407. Epub 2020 Nov 10.

Department of Otorhinolaryngology, Head and Neck Surgery, Ibn Rochd Hospital, King Hassan II University, Morocco.

Squamous cell carcinoma (SCC) of the tongue is one of the most common cancers in the oral region, most frequently associated with lymph nodes metastases which influence the most the prognosis. The identification of predictive factors of occult cervical nodal metastases for N0 tumors will allow to adapt the treatment to the patient, avoiding over or under management. From 2014 to 2019, a cohort of 26 patients with SCC of the mobile tongue was reviewed by analysing the medical history, the epidemiological and clinical parameters, the tumor sites, aspects, diameters, depths of invasion, pathological degree, degree of differentiation, T classification and results of neck dissections. Read More

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December 2020

Adjuvant management of locally advanced oral squamous cell carcinoma - real-world challenges and opportunities.

Br J Oral Maxillofac Surg 2020 Aug 20. Epub 2020 Aug 20.

Head and Neck Unit, Aintree University Hospital NHS Foundation Trust, Longmoor Lane, Fazakerly, Liverpool, L9 7AL, United Kingdom; Liverpool Head & Neck Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool Cancer Research Centre, University of Liverpool, Liverpool, L69 3BX, United Kingdom.

Patients with locally advanced oral squamous cell cancer (LAOSCC) are treated with adjuvant radiotherapy (RT) or chemoradiotherapy (CRT) following surgical ablation. This depends on the pathological risk factors and aims to reduce the risk of local recurrence and improve survival. Delivery of these aggressive treatments is, however, challenging particularly following major surgery. Read More

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Impact of submandibular gland preservation in neck management of early-stage buccal squamous cell carcinoma on locoregional control and disease-specific survival.

BMC Cancer 2020 Oct 27;20(1):1034. Epub 2020 Oct 27.

Department of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, People's Republic of China.

Background: The feasibility of submandibular gland (SMG) preservation in oral squamous cell carcinoma (SCC) has occasionally been analyzed, but the differences in survival associated with the presence or absence of SMG preservation remain unknown. We aimed to prospectively evaluate the oncologic results of SMG preservation in cT1-2 N0 buccal SCC.

Methods: This was a prospective, non-randomized cohort study. Read More

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October 2020

Long-term outcomes of patients with papillary thyroid cancer who did not undergo prophylactic central neck dissection.

J Cancer Res Ther 2020 Sep;16(5):1077-1081

Department of Head and Neck Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Aims: The role of prophylactic central neck dissection (CND) in the management of papillary thyroid carcinoma (PTC) is controversial. This study reports outcomes of an observational approach in PTC patients without clinical evidence of lymph node metastasis.

Materials And Methods: Patients with PTC who had surgery (without prophylactic CND) between January 2000 and December 2008 were included in this study. Read More

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September 2020

Indications and outcomes of superselective neck dissection: A review and analysis of the literature.

Laryngoscope Investig Otolaryngol 2020 Aug 25;5(4):672-676. Epub 2020 Jun 25.

Department of Otolaryngology-Head and Neck Surgery Emory University Atlanta Georgia USA.

Superselective neck dissection, defined as dissection of two or less contiguous neck levels, has recently been introduced to reduce surgical morbidity of neck dissection while maintaining favorable oncologic outcomes. The purpose of this review is to report the results of superselective neck dissection when applied to specific settings: the management of regional disease after chemoradiation, head and neck squamous cell carcinoma with clinical N0 necks, and high risk papillary thyroid carcinoma. Read More

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Accuracy of the preoperative diagnostic workup in patients with head and neck cancers undergoing neck dissection in terms of nodal metastases.

Eur Arch Otorhinolaryngol 2021 Jun 29;278(6):2041-2046. Epub 2020 Aug 29.

Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Szigony Str. 36, Budapest, 1083, Hungary.

Purpose: The presence of cervical lymph node metastases is one of the most influential prognostic factors in head and neck squamous cell carcinomas. The management of clinically N0 neck in patients with head and neck cancer remains controversial: elective neck dissection has relatively high morbidity, adversely affecting the quality of life, however, abandoning elective neck dissection is known to compromise overall survival in numerous primaries. The purpose of this study was to evaluate the accuracy of the conventional imaging modalities (CT, MRI, US) and fine-needle aspiration cytology (FNAC) in the detection of lymph node metastases in the neck. Read More

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Management of the clinically N neck in early-stage oral squamous cell carcinoma (OSCC). An EACMFS position paper.

J Craniomaxillofac Surg 2020 Aug 2;48(8):711-718. Epub 2020 Jul 2.

Department of Head & Neck Surgery, University College London Hospital, London, UK. Electronic address:

Metastasis of oral squamous cell carcinoma (OSCC) to the cervical lymph nodes has a significant impact on prognosis. Accurate staging of the neck is important in order to deliver appropriate treatment for locoregional control of the disease and for prognosis. The management of the neck in early, low volume disease (clinically T/T oral cavity tumours) has long been debated. Read More

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A rare coexistence of papillary carcinoma and anaplastic carcinoma of thyroid in multinodular goitre: Case report and literature review.

Ann Med Surg (Lond) 2020 Aug 27;56:161-164. Epub 2020 Jun 27.

Otorhinolaryngology Head and Neck Surgery, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.

Introduction: Multinodular goiter is defined as multiple discrete nodules in the thyroid gland. The incidence of Papillary carcinoma thyroid was found to be highest out of total Multinodular Goiter cases while that of Anaplastic carcinoma was the least. We report a rare coexistence of Papillary carcinoma and Anaplastic carcinoma in adult patient with a long-standing Multinodular Goiter. Read More

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Evaluation of metastatic lymph nodes in cN0 thoracic esophageal cancer patients with inconsistent pathological lymph node diagnosis.

World J Surg Oncol 2020 May 29;18(1):111. Epub 2020 May 29.

Department of Thoracic Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.

Background: Preoperative clinical diagnosis of lymph node (LN) metastasis and subsequent pathological diagnosis are often not in agreement. Detection of false-negative LNs is essential in selecting an optimal treatment strategy, and most importantly, the presence of false-negative LN is itself a significant prognostic indicator. Therefore, at present, there is an urgent need to establish more accurate and individualized evaluation methods for LN metastasis. Read More

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Meta-analysis of risk of occult lymph node metastasis in the irradiated, clinically N0 neck.

Head Neck 2020 09 19;42(9):2355-2363. Epub 2020 May 19.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California, USA.

Background: Recurrent head and neck squamous cell carcinoma (HNSCC) after radiation is associated with poor survival, and management of the clinically negative (N0) neck during salvage surgery is controversial.

Methods: Studies were selected according to preferred reporting items for systematic reviews and meta-analyses guidelines. Inclusion criteria were patients with HNSCC, prior radiation to the lateral neck nodal basin, undergoing salvage surgery for local recurrence, persistence or second primary, and N0 at time of salvage. Read More

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September 2020

Sentinel lymph node biopsy in clinically node negative patients with papillary thyroid carcinoma.

J BUON 2020 Jan-Feb;25(1):376-382

Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.

Purpose: The incidence of histologically proven lymph node metastases (LNM) in papillary thyroid carcinoma (PTC) reaches 80%. According to different guidelines surgical management in clinically N0 (cN0) patients with PTC remains controversial. The purpose of this study was to investigate if sentinel lymph node biopsy (SLNb) using methylene blue dye is accurate in the detection of LNM in the lateral neck compartment in cN0 patients with PTC. Read More

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December 2020

Transoral resection with buccinator flap reconstruction vs. pull-through resection and free flap reconstruction for the management of T1/T2 cancer of the tongue and floor of the mouth.

J Craniomaxillofac Surg 2020 May 24;48(5):514-520. Epub 2020 Feb 24.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.

Aim: To compare the most important techniques usually used in these patients.

Materials And Methods: A multicentric retrospective evaluation on patients treated for cT1/2 N0 OTFOM SCC was conducted; patients in group A were treated by transoral approach and miomucosal local flap while those in group B were treated by pull-through and free flap reconstruction. Oncologic, functional and quality of life evaluation was assessed. Read More

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Elective neck dissection for salvage total laryngectomy: A systematic review, meta-analysis and "decision-to-treat" approach.

Clin Otolaryngol 2020 07 7;45(4):558-573. Epub 2020 Apr 7.

Department of ENT Surgery, Poole Hospitals NHS Foundation Trust, Poole, UK.

Introduction: The authors provide an updated, systematic and comprehensive summary of the literature concerning management of the N0 neck in patients for whom primary irradiation for squamous cell carcinoma of the larynx has been unsuccessful and salvage surgery in the form of total laryngectomy (TL) advocated.

Methods: Bibliographic databases MEDLINE, Cochrane, PubMed and Embase were searched from inception to April 2019, with no language restrictions. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Read More

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Neck nodal recurrence and survival of clinical T1-2 N0 oral squamous cell carcinoma in comparison of elective neck dissection versus observation: A meta-analysis.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Apr 5;129(4):296-310. Epub 2019 Nov 5.

Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:

Objective: The clinical management of patients with T1-2 oral squamous cell carcinoma (OSCC) and clinically node-negative neck (cN0) continues to be controversial. We performed a systematic review of the literature to assess the effect of elective neck dissection (END) and neck observation (OBS) on the prognosis of patients with cT1-2 N0 OSCC.

Study Design: PubMed, Embase, and Cochrane Library were searched for studies related to END and OBS in patients with cT1-2 N0 OSCC. Read More

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Modified in-continuity resection is advantageous for prognosis and as a new surgical strategy for management of oral tongue cancer.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 May 14;129(5):453-460. Epub 2019 Oct 14.

Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: The aim of this study was to explore the application value of modified in-continuity resection compared with traditional in-continuity resection and discontinuous resection for patients with cT2 N0 M0 oral tongue squamous cell carcinoma.

Study Design: This was a retrospective cohort study. The predictor was surgical management. Read More

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Sentinel lymph node biopsy with preoperative CT lymphography and intraoperative indocyanine green fluorescence imaging for N0 early tongue cancer: A long-term follow-up study.

J Craniomaxillofac Surg 2020 Mar 25;48(3):217-222. Epub 2020 Jan 25.

Department of Oral and Maxillofacial Surgery/Orthodontics, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.

Purpose: This study evaluated the usefulness of sentinel lymph node (SLN) biopsy with preoperative computed tomographic lymphography (CTL) and intraoperative indocyanine green (ICG) fluorescence imaging for N0 early tongue cancer.

Methods: Twenty-seven patients with N0 early oral tongue cancer underwent CTL with a 128-slice multi-detector row CT scanner to detect SLN on the day before resection of primary tumor and SLN biopsy under ICG fluorescence guidance. We identified the location and number of SLNs mapped by CTL and evaluated whether CTL-enhanced SLNs could be identified intraoperatively as ICG fluorescent lymph nodes. Read More

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Development and validation of a multivariable prediction model for the identification of occult lymph node metastasis in oral squamous cell carcinoma.

Head Neck 2020 08 14;42(8):1811-1820. Epub 2020 Feb 14.

Department of Otolaryngology - Head and Neck Surgery, Geneva University Hospital and Faculty of Medecine of the University of Geneva, Geneva, Switzerland.

Background: There have been few recent advances in the identification of occult lymph node metastases (OLNM) in oral squamous cell carcinoma (OSCC). This study aimed to develop, compare, and validate several machine learning models to predict OLNM in clinically N0 (cN0) OSCC.

Methods: The biomarkers CD31 and PROX1 were combined with relevant histological parameters and evaluated on a training cohort (n = 56) using four different state-of-the-art machine learning models. Read More

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Squamous Cell Carcinoma of a Thyroglossal Duct Cyst and the Role of a Level IA Neck Dissection.

ORL J Otorhinolaryngol Relat Spec 2020;82(3):163-167. Epub 2020 Feb 4.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA,

Squamous cell carcinoma of a thyroglossal duct cyst is exceedingly rare, with less than 30 cases reported across the literature. Herein, we present a case of squamous cell carcinoma (SCC) of a thyroglossal duct cyst (TGDC) and discuss the utility of a level IA neck dissection in these cases. In 2018, a 62-year-old female presented to a university-affiliated otolaryngologist with symptoms of dysphagia and a palpable anterior midline neck mass. Read More

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Management of the irradiated N0-neck during salvage pharyngo-laryngeal surgery.

Eur J Surg Oncol 2020 06 9;46(6):1059-1065. Epub 2020 Jan 9.

Department of Surgery, University Cancer Institute Toulouse - Oncopôle, University Hospital of Toulouse, Toulouse, France. Electronic address:

Background: Salvage surgeries are challenging procedures, with an associated poor prognosis. Management of the N0 neck in those situations remains controversial. We aim to compare oncologic outcomes regarding neck management after surgery for N0 pharyngo-laryngeal carcinoma occurring after loco-regional radiotherapy. Read More

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Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis.

Head Neck 2020 05 10;42(5):1057-1066. Epub 2020 Jan 10.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University Vienna, Vienna, Austria.

Sinonasal undifferentiated carcinomas (SNUCs), being an aggressive malignancy with dismal survival outcome, have given limited consideration regarding management of regional failures. A total of 12 studies, published between 1999 and 2019, met inclusion criteria. We performed a meta-analysis assessing regional (neck) relapse after elective neck treatment compared to observation in clinically node negative (N0) necks. Read More

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High serum CCL18 predicts a poor prognosis in patients with laryngeal squamous cell carcinoma.

J Cancer 2019 17;10(27):6910-6914. Epub 2019 Nov 17.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China.

CCL18 is a cytokine secreted by M2 type tumor associated macrophages, which frequently over-expressed in diverse human cancers. However, the clinical significance of serum CCL18 in patients with laryngeal squamous cell carcinoma (LSCC) remains unknown. In this study, serum CCL18 was initially quantified by enzyme-linked immunosorbent assay (ELISA) in 146 patients with LSCC, 25 patients with precancerous lesions and 72 healthy volunteers. Read More

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November 2019

Neck management in patients with olfactory neuroblastoma.

Oral Oncol 2020 02 10;101:104505. Epub 2019 Dec 10.

Department of Oncology, 920(th) Hospital of Joint Logistics Support Force, 212 Daguan Road, Kunming 650032, China. Electronic address:

Objective: Optimal neck management in patients with olfactory neuroblastoma (ONB), a rare malignancy, remains uncertain. This study aimed to analyse patterns of cervical lymph node metastases and corresponding clinical outcomes and to investigate the value of elective neck irradiation (ENI) in this population.

Methods And Materials: This study retrospectively reviewed clinical records, imaging findings, nodal metastasis features and treatment data of 217 patients with ONB treated at our hospital during 1991-2019. Read More

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February 2020

Early tongue carcinomas (clinical stage I and II): echo-guided three-dimensional diode laser mini-invasive surgery with evaluation of histological prognostic parameters. A study of 85 cases with prolonged follow-up.

Lasers Med Sci 2020 Apr 13;35(3):751-758. Epub 2019 Dec 13.

Department of Interdisciplinary Medicine, University of Bari, Piazza G. Cesare, 11, 70124, Bari, Italy.

The management of patients with early stage (cT1-T2) tongue squamous cell carcinoma without clinicoradiologic evidence of neck node metastasis (cN0) has been widely debated over the last 3 decades and still remains controversial. Nevertheless, the identification of patients with low-stage tumours at high-risk for occult cervical metastases is imperative before planning treatments of primary tumours, as well as that of prognostic markers which may possibly select those patients who may benefit of additional workup after surgery in view of the high metastatic potential of the primary tumour. The pre-surgical evaluation of tongue malignant primary tumour (for assessing lateral and deep margins) along with diode laser surgery (with accurate incision, bleeding-free and with reduced/absent post-surgical complications) may lead to a more conservative but equally decisive surgical treatment, also with a greater patient compliance. Read More

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