Search Our Scientific Publications & Authors

Medicine (Baltimore) 2021 Apr;100(14):e25136

Department of Gastroenterology, Jiangjin District Central Hospital, Chongqing, China, 402260.

Background: Proton pump inhibitors (PPIs) decrease the rate of rebleeding following endoscopic hemostatic therapy in patients with bleeding peptic ulcers. This study compares the efficacy of oral omeprazole vs intravenous omeprazole in decrease of rebleeding of peptic ulcer patients.

Method: The present study was authorized by the local research ethics committee of Jiangjin District Central Hospital (2020120987) and informed consent was obtained from all patients. Read More

Vasc Endovascular Surg 2021 Jul 8;55(5):510-514. Epub 2021 Feb 8.

Cardiovascular Intervention Research Center, 158776Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Intramural hematoma of the esophagus (IHE) represents a rare condition on the spectrum of esophageal injuries. The most common symptoms are hematemesis, epigastric pain or retrosternal chest pains, odynophagia, and dysphagia. Early recognition of IHE is important as it may mimic other diseases such as myocardial infarction, pulmonary embolism, Mallory-Weiss tears, Boerhaave's syndrome, ruptured aortic aneurysms, and aortic dissection. Read More

Cureus 2020 Dec 24;12(12):e12256. Epub 2020 Dec 24.

Emergency Medicine, Swedish Hospital - Part of NorthShore University HealthSystem, Chicago, USA.

Emergency departments (EDs) are the primary driver for hospital admissions in the United States (US), and that trend is likely to continue through the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. As the US continues to experience rampant community spread, coronavirus disease 2019 (COVID-19) will likely present in increasingly variable ways to the EDs. We present a case of Mallory-Weiss tear and esophageal perforation, which was likely caused by COVID-19 pneumonia. Read More

Cureus 2020 Dec 3;12(12):e11862. Epub 2020 Dec 3.

Internal Medicine Department, University of Tabuk, Tabuk, SAU.

Introduction Upper gastrointestinal bleeding (UGIB) is defined as any blood loss originating from the esophagus, stomach or the proximal duodenum above the ligament of Treitz. Ethnic trends regarding the causes of UGIB have been reported. The aim of this study was to identify the most common causes of UGIB among patients residing in Tabuk city, Saudi Arabia. Read More

Int J Emerg Med 2020 Nov 30;13(1):56. Epub 2020 Nov 30.

Department of Emergency and Disaster Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: Spontaneous esophageal rupture, or Boerhaave syndrome, is a fatal disorder caused by an elevated esophageal pressure owing to forceful vomiting. Patients with Boerhaave syndrome often present with chest pain, dyspnea, and shock. We report on two patients of Boerhaave syndrome with different severities that was triggered by excessive alcohol consumption and was diagnosed immediately in the emergency room. Read More

Nihon Shokakibyo Gakkai Zasshi 2020 ;117(11):985-991

Department of Gastroenterology and Hepatology, Tokyo Medical University Hospital.

An 86-year-old man was transferred to the Tokyo Medical University Hospital because of a temporary loss of consciousness and melena. We performed upper gastrointestinal endoscopy, which revealed Mallory-Weiss syndrome caused by a strong vomiting reflex. After an examination, he complained of abdominal pain, and his blood pressure decreased. Read More

Clin Endosc 2020 Nov 12. Epub 2020 Nov 12.

Department of Gastroenterology, Osaka City General Hospital, Osaka, Japan.

Mallory-Weiss tears (MWT) are occasionally encountered during endoscopic procedures. Esophageal endoscopic submucosal dissection (ESD) is widely performed under general anesthesia to avoid unexpected body movements. We present the case of a 68-year-old woman with squamous cell carcinoma. Read More

GE Port J Gastroenterol 2020 Aug 8;27(5):356-360. Epub 2020 Jan 8.

Department of Gastroenterology, T.N.M.C. and B.Y.L. Nair Charitable Hospital, Mumbai, India.

Esophageal mucosal bridge is an elastic stretchable structure, connecting across the lumen, extending either obliquely or horizontally, more commonly seen in the mid or lower esophagus. It can be either congenital or secondary (acquired). Acquired ones are secondary to reflux esophagitis, corrosive esophageal injury, drug-induced esophagitis, radiation esophagitis, Crohn's disease, Mallory-Weiss syndrome, malignant tumors, and infections like candidiasis, HSV, CMV, or tuberculosis. Read More

Am Fam Physician 2020 03;101(5):294-300

Medical College of Georgia at Augusta University, Augusta, GA, USA.

Upper gastrointestinal (GI) bleeding is defined as hemorrhage from the mouth to the ligament of Treitz. Common risk factors for upper GI bleeding include prior upper GI bleeding, anticoagulant use, high-dose nonsteroidal anti-inflammatory drug use, and older age. Causes of upper GI bleeding include peptic ulcer bleeding, gastritis, esophagitis, variceal bleeding, Mallory-Weiss syndrome, and cancer. Read More

Int J Clin Exp Pathol 2019 1;12(7):2758-2762. Epub 2019 Jul 1.

Lung Cancer Center, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University Chengdu, Sichuan, China.

The presence of Mallory-Weiss syndrome (MWS) in patients with small-cell lung cancer (SCLC) is uncommon. MWS is characterized by longitudinal superficial mucosal laceration at the esophagogastric junction and can be caused by a variety of causes, with upper digestive tract hemorrhage as the primary manifestation. SCLC is the most invasive histological subtype of lung cancer, and approximately a quarter of all SCLC patients undergo paraneoplastic syndrome of inappropriate antidiuretic hormone secretion, such as hyponatremia. Read More

World J Clin Cases 2019 Dec;7(24):4407-4413

Department of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, Changchun 130031, Jilin Province, China.

Background: Upper gastrointestinal bleeding (UGIB) after an acute myocardial infarction (AMI) is not an uncommon complication. Acute UGIB caused by Mallory-Weiss syndrome (MWS) is usually a dire situation with massive bleeding and hemodynamic instability. Acute UGIB caused by MWS after an AMI has not been previously reported. Read More

Middle East J Dig Dis 2019 Oct 5;11(4):225-229. Epub 2019 Nov 5.

Department of Internal Medicine, Shahid Beheshti Medical University, Tehran, Iran.

Polycythemia vera (PV) is classified as a myeloproliferative disorder (MPD). Such patients are prone to both thrombotic and hemorrhagic events. Although gastrointestinal (GI) bleeding is not a prominent manifestation of PV, it would be life threatening and necessitating hospital admission and blood transfusion if it occurs. Read More

Cureus 2019 Sep 11;11(9):e5623. Epub 2019 Sep 11.

Gastroenterology, State University of New York Upstate Medical University, Syracuse, USA.

Intramural esophageal hematoma (IEH) is a rare cause of submucosal esophageal bleeding and it is on the spectrum of esophageal wall injury along with mucosal tears (Mallory-Weiss syndrome) and full thickness perforation (Boerhaave's syndrome). Its risk factors include coagulopathy, trauma (foreign body ingestion or esophageal instrumentation) or it can happen spontaneously. It presents with a triad of chest pain, dysphagia, and hematemesis; however, the triad is only present in 35% of patients. Read More

World J Gastroenterol 2019 Sep;25(34):5174-5184

Department of Gastroenterology and Hepatology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Adverse events during endoscopic submucosal dissection (ESD) of superficial esophageal neoplasms, such as perforation and bleeding, have been well-documented. However, the Mallory-Weiss Tear (MWT) during esophageal ESD remains under investigation.

Aim: To investigate the incidence and risk factors of the MWT during esophageal ESD. Read More

Chirurg 2019 Aug;90(8):607-613

Universitätsklinik für Allgemeine, Viszeral- und Transplantationschirurgie, Universitätsklinikum Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Deutschland.

Background: Nonvariceal upper gastrointestinal bleeding (UGIB) has a high mortality. Hematemesis sometimes with melena are the leading clinical symptoms. Peptic ulcers and (erosive) inflammation are common, whereas Mallory-Weiss syndrome, neoplasms, angiodysplasia and diffuse UGIB are less common. Read More

Dig Dis Sci 2020 01 31;65(1):225-231. Epub 2019 Jul 31.

Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.

Background/aims: Spontaneous retrograde migration of nasoenteral feeding tubes is common in clinical practice. The aim of the present study was to evaluate the effectiveness of nasoenteral feeding tube tip fixation with hemoclips to prevent tube dislodgement.

Methods: We retrospectively reviewed patients who underwent insertion of an endoscopic nasoenteral feeding tube with or without tube tip fixation with hemoclips at the Asan Medical Center in Korea from January 2016 to December 2017. Read More

Clin Endosc 2020 Jan 8;53(1):90-93. Epub 2019 Jul 8.

Division of Gastroenterology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.

Peptic ulcer disease is the most common cause of acute gastrointestinal bleeding, followed by variceal bleeding, Mallory-Weiss syndrome, and malignancy. On the contrary, acquired hemophilia A is a very rare hemorrhagic disease, which usually manifests with musculocutaneous bleeding, caused by autoantibodies against coagulation factor VIII. A 78-year-old man presented to the Emergency Department with melena. Read More

Frontline Gastroenterol 2019 Apr 2;10(2):112-154. Epub 2018 Nov 2.

Gastroenterology Unit, Valduce Hospital, Como, Italy.

We present an uncommon case of a patient presenting at the emergency department for severe vomiting, persisting for at least 12 hours, without nausea or abdominal pain. She initially referred vomiting food eaten several hours earlier and eventually a single episode of haematemesis with emission of a small amount of red blood and clots. She also reported the occurrence of acute dysphagia for solid food. Read More

Medicine (Baltimore) 2019 May;98(22):e15751

Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Mallory-Weiss syndrome (MWS) is a relatively less common cause of nonvariceal upper gastrointestinal bleeding. There is limited data on whether scoring systems could be used to predict the clinical outcomes in patients with bleeding due to MWS. The aim of our study is to evaluate whether the Glasgow-Blatchford score (GBS), AIMS65, and shocking index are effective in predicting the clinical outcomes of MWS. Read More

Eur J Gastroenterol Hepatol 2019 Jul;31(7):781-785

Department of Emergency Medicine, Asan Medical Center, College of Medicine, University of Ulsan.

Objective: Risk assessment in nonvariceal upper gastrointestinal bleeding (UGIB) is not well validated and remains unclear in hemodynamically stable patients at emergency department admission. We compared the prognostic value of risk-scoring systems for predicting adverse outcomes in patients with nonvariceal UGIB and normotension.

Participants And Methods: A single-center prospective observational study was carried out. Read More

Am Surg 2019 Mar;85(3):e179-e181

BMJ Case Rep 2019 Mar 22;12(3). Epub 2019 Mar 22.

Hepatology, Bristol Royal Infirmary, Bristol, UK.

Wideochir Inne Tech Maloinwazyjne 2019 Jan 30;14(1):133-136. Epub 2018 May 30.

Department of Gastroenterology, Chinese PLA 153 Hospital, Zhengzhou, China.

There are no previous reports of Mallory-Weiss tears occurring as complications during esophageal endoscopic submucosal dissection (ESD). We present 3 cases of Mallory-Weiss tears occurring during treatment of superficial squamous cell neoplasms through ESD. Carbon dioxide was used for air insufflation, and the patient was adequately sedated without retching or struggling during the operation. Read More

Dig Dis Sci 2019 02;64(2):349-352

Division of Gastroenterology and Hepatology, Department of Medicine, University of New Mexico School of Medicine, 1 University of New Mexico, MSC10-5550, Albuquerque, NM, 87131, USA.

Medicine (Baltimore) 2018 Dec;97(49):e13191

Department of Legal and Forensic Medicine, University of Genova, Genova.

Rationale: Spontaneous esophageal rupture (Boerhaave syndrome) is a rare, though frequently fatal, event. It is generally caused by a sudden increase in pressure inside the esophagus. In some cases, full-thickness perforations of the esophagus may develop from previous lesions that initially involve only the esophageal mucosa (Mallory-Weiss syndrome) and which, following further triggering events, give rise to a transmural lesion. Read More

ACG Case Rep J 2018 26;5:e66. Epub 2018 Sep 26.

Division of Epidemiology and Biostatistics, Western Michigan University, MD Homer Stryker School of Medicine, Kalamazoo, MI.

Spontaneous intramural esophageal rupture (SIER) is a form of acute esophageal trauma defined as an injury deeper than a Mallory-Weiss tear but not extending completely through the muscular propria as in Boerhaave syndrome. SIER is a rare complication of eosinophilic esophagitis (EoE); after extensive literature review, we found 7 case reports of SIER complicating EoE. We present a case of SIER complicating EoE in a 46-year-old man with an atypical presentation requiring endoscopic clipping to achieve successful hemostasis. Read More

Dig Dis Sci 2018 12 21;63(12):3253-3261. Epub 2018 Aug 21.

Kyungpook National University Hospital, Daegu, South Korea.

Background And Aims: Compared with ulcer bleeding (UB) in non-variceal upper gastrointestinal bleeding (NVUGIB), non-ulcer bleeding (NUB) is often considered to have a low risk of poor outcomes and is treated less intensively without any risk stratification. We conducted this study to assess the predictability of scoring systems for NUB and compare the outcomes of NUB and UB.

Methods: A total of 1831 UGIB patients were registered in the database during the period from February 2011 to December 2013. Read More

Gastrointest Endosc Clin N Am 2018 Jul 17;28(3):291-306. Epub 2018 Apr 17.

Division of Gastroenterology, University of California, 9500 Gilman Drive #0956, La Jolla, CA 92093-0956, USA.

Nonvariceal, nonulcer upper gastrointestinal hemorrhage (UGIH) is a less common cause for acute upper gastrointestinal bleeding. However, nonvariceal, nonulcer UGIH is an important entity to identify and treat appropriately to prevent bleeding-related morbidity and mortality. Over the past 40 years, there has been a revolution in gastrointestinal endoscopy and a similar revolution in the management of UGIH. Read More

J Vasc Nurs 2018 06;36(2):91-93

Franciscan Health - Michigan City, Michigan City, Indiana. Electronic address: