3,704 results match your criteria Mallet Fracture


A Modified Pull-out Wire Technique for Acute Mallet Fracture of the Finger.

Indian J Orthop 2018 Nov-Dec;52(6):611-615

Orthopaedic Surgery Department, Section of Hand Surgery, Changhua Christian Hospital, Changhua, Taiwan, ROC.

Background: A variety of surgical techniques for treating mallet fracture finger has been reported with different outcomes and complications. However, the optimal procedure remains controversial. This study describes surgical outcomes of mallet fractures of the finger with distal phalanx treated by modified pull-out wire fixation with Kirschner wire (K-wire) stabilization of the DIP joint in hyperextension. Read More

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December 2018

Letter to the Editor: "Characterization of the CYP11A1 Non-synonymous Variant p.E314K in Children Presenting with Adrenal Insufficiency".

J Clin Endocrinol Metab 2018 Nov 30. Epub 2018 Nov 30.

Laboratoire de Biochimie et Biologie Moléculaire Grand Est, UM Pathologies Endocriniennes Rénales Musculaires et Mucoviscidose, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France.

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November 2018
4 Reads

Treatment of tendinous mallet fingers using a Stack splint versus a dorsal glued splint.

Eur J Orthop Surg Traumatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Hand Surgery, SOS Main, CCOM, Icube CNRS, 7357, University Hospital of Strasbourg, FMTS, University of Strasbourg, 10 Avenue Baumann, 67400, Illkirch, France.

The goal of this study was to compare the results of a Stack splint compared to a dorsal glued splint in the treatment of tendinous mallet fingers. Our series included 100 patients, aged 47 years in average, among which 40 are women, with a 9-week follow-up. The first 50 patients (group I) were treated with a dorsal glued splint, and the 50 following patients (group II) were treated with a Stack splint. Read More

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November 2018
3 Reads

Alternative facts: a reconsideration of putatively natural interspecific hybrid specimens in the genus Heliconius (Lepidoptera: Nymphalidae).

Zootaxa 2018 Oct 12;4499(1):1-87. Epub 2018 Oct 12.

Evolution and Ecology Group, Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132 USA..

Mallet et al. (2007 BMC Evolutionary Biology, 7, 28) employed a database of putative interspecific hybrid specimens of the genus Heliconius to advance a hypothesis of "the species boundary as a continuum." Here, each of those specimens, as well as subsequently documented specimens, is individually reassessed regarding its phenotype, potential parentage and chain of custody in collections. Read More

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October 2018
1 Read

Crazy'App: A web survey on representations and attitudes toward mental disorders using video testimonies.

Encephale 2018 Nov 20. Epub 2018 Nov 20.

Cermes3 - Centre de recherche médecine, sciences, santé, santé mentale et société, université Paris Descartes, 7, rue Guy-Môquet, BP 8, 94801 Villejuif cedex, France.

In the international context of efforts to combat the stigmatization of people with mental health problems, representations and attitudes about these illnesses have not to date been widely investigated in France. However, new technologies offer an unprecedented opportunity to collect such information on a large scale and to deploy more efficient action against stigma.

Objectives: The Crazy'App survey was designed as an instrument for studying potentially stigmatizing representations and attitudes towards mental disorders. Read More

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November 2018
1 Read

Apolipoprotein D Upregulation in Alzheimer's Disease but Not Frontotemporal Dementia.

J Mol Neurosci 2018 Nov 22. Epub 2018 Nov 22.

Central Clinical School and Brain and Mind Centre, Faculty of Medicine and Health Sciences, The University of Sydney, 94 Mallet Street, Camperdown, NSW, Australia.

Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are the two common forms of dementia. FTD syndromes are characterized by lobar atrophy (frontotemporal lobar degeneration or FTLD) and the presence of either cellular TDP43 (FTLD-TDP), tau (FTLD-tau), or FUS aggregates, while extracellular β-amyloid plaques and hyperphosphorylated tau tangles develop in AD. Oxidative stress can induce these pathological modifications in disease models, and is thought to play a role in these syndromes. Read More

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November 2018

Are elderly patients presenting with squamous cell carcinoma of the oral cavity given the appropriate treatment?

Surg Oncol 2018 Dec 2;27(4):715-721. Epub 2018 May 2.

Universitary Hospital Pitié Salpêtrière, AP-HP, Department of Maxillo-facial Surgery, 47-83 boulevard de l'hôpital, 75 651 Paris Cedex 13, France; Pierre & Marie Curie University, 4 Place Jussieu 75252 Paris Cedex 05, France.

Objectives: There is no consensus for the specific management of elderly patients presenting with oral cavity squamous cell carcinomas (OC SCC). We report our findings in the treatment of primary OC SCC, for patients of 70 years of age or more, in a French university hospital center.

Patients And Methods: One hundred and twenty five patients diagnosed between 2000 and 2010, were included retrospectively. Read More

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December 2018
3 Reads

Metagenomic Next-Generation Sequencing Reveals Individual Composition and Dynamics of Anelloviruses during Autologous Stem Cell Transplant Recipient Management.

Viruses 2018 Nov 14;10(11). Epub 2018 Nov 14.

Laboratoire Commun de Recherche HCL-bioMerieux, Centre Hospitalier Lyon Sud, 69495 Pierre-Bénite, France.

Over recent years, there has been increasing interest in the use of the anelloviruses, the major component of the human virome, for the prediction of post-transplant complications such as severe infections. Due to an important diversity, the comprehensive characterization of this viral family over time has been poorly studied. To overcome this challenge, we used a metagenomic next-generation sequencing (mNGS) approach with the aim of determining the individual anellovirus profile of autologous stem cell transplant (ASCT) patients. Read More

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November 2018
6 Reads

Inflammatory DEpression Advances in Schizophrenia (IDEAS): A precision medicine approach of the national FACE-SZ cohort.

J Affect Disord 2018 Nov 6;245:468-474. Epub 2018 Nov 6.

Fondation FondaMental, Créteil, France; CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69 63003, Clermont-Ferrand Cedex 1, France.

Background: Major Depressive Disorder (MDD) is a therapeutic challenge in schizophrenia (SZ). Untangling different forms of MDD appears as the best current strategy to improve remission to treatment in the so-called precision medicine approach.

Aims: The objectives of the present study were to determine (i) the prevalence of Inflammatory Depression (ID) in stabilized SZ outpatients (ii) if ID was associated with clinical or cognitive profiles that may help clinicians detecting ID (iii) if antidepressants were effective in ID and (iv) the biological correlates of ID that may orientate personalized treatments. Read More

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November 2018
8 Reads

Assimilation of mobile phone measurements for noise mapping of a neighborhood.

J Acoust Soc Am 2018 Sep;144(3):1279

INRIA, 2 rue Simone Iff, 75012 Paris, France.

Noise maps are a key asset in the elaboration of urban noise mitigation policies. However, simulation-based noise maps are subject to high uncertainties, and the estimation of population exposition to noise pollution generally relies on static averages over an extended period of time. This paper introduces a method to produce hourly noise maps based on temporally averaged simulation maps and mobile phone audio recordings. Read More

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September 2018
5 Reads

Dermatological manifestations in Noonan syndrome: A prospective multicentric study of 129 mutation-positive patients.

Br J Dermatol 2018 Nov 12. Epub 2018 Nov 12.

Department of Genetic Biochemistry, Robert-Debré Hospital, AP-HP and University of Paris-Diderot, Paris, France.

Background: Data on dermatological manifestations of Noonan syndrome (NS) remain heterogeneous and based on little dermatological expertise.

Objectives: To describe the dermatological manifestations of NS, compare them with the literature findings, and test for dermatological phenotype-genotype correlations with or without the presence of PTPN11 mutations.

Methods: We performed a large, 4-year, prospective, multicentric, collaborative dermatological and genetic study. Read More

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November 2018
2 Reads

Accurate control of the covalent functionalization of single-walled carbon nanotubes for the electro-enzymatically controlled oxidation of biomolecules.

Beilstein J Nanotechnol 2018 26;9:2750-2762. Epub 2018 Oct 26.

SRSMC, UMR CNRS-Université de Lorraine 7565, Campus Victor Grignard, Faculté des Sciences et Technologies, F-54506 Vandoeuvre-lès-Nancy, France.

Single-walled carbon nanotubes (SWCNTs) were functionalized by ferrocene through ethyleneglycol chains of different lengths (FcETGn) and the functionalized SWCNTs (f-SWCNTs) were characterized by different complementary analytical techniques. In particular, high-resolution scanning electron transmission microscopy (HRSTEM) and electron energy loss spectroscopy (EELS) analyses support that the outer tubes of the carbon-nanotube bundles were covalently grafted with FcETGn groups. This result confirms that the electrocatalytic effect observed during the oxidation of the reduced form of nicotinamide adenine dinucleotide (NADH) co-factor by the f-SWCNTs is due to the presence of grafted ferrocene derivatives playing the role of a mediator. Read More

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October 2018

Plantar Plate Injury and Angular Toe Deformity.

Foot Ankle Clin 2018 Dec 25;23(4):703-713. Epub 2018 Sep 25.

Orthopaedic Surgery, Tri-State Specialist, LLC, Suite 300, 2730 Pierce Street, Sioux City, IA 51104, USA.

Lesser toe plantar plate injuries at the metatarsophalangeal (MTP) joint are a common source of metatarsalgia. The second MTP joint is the most commonly affected digit. The fibrocartilaginous plantar plate is the most important static stabilizer of the MTP joint; high loading with weight bearing can lead to attritional plantar plate injuries. Read More

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December 2018
15 Reads

Supplemental Method for Reduction of Irreducible Mallet Finger Fractures by the 2-Extension Block Technique: The Dorsal Counterforce Technique.

J Hand Surg Am 2018 Nov 5. Epub 2018 Nov 5.

Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Korea.

Purpose: We suggest a method to achieve anatomical reduction in mallet finger fractures that are insufficiently treated by the 2-extension block wire technique.

Methods: We performed a retrospective review of 18 patients who were found to have an irreducible dorsal fragment and distal interphalangeal joint incongruence owing to rotation of the dorsal fragment in the sagittal plane. In these cases, we additionally employed a dorsal counterforce technique to supplement the 2-extension block technique. Read More

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November 2018
1 Read

Can microtubule motors use every available track?

Authors:
Prachee Avasthi

J Cell Biol 2018 Dec 7;217(12):4055-4056. Epub 2018 Nov 7.

Department of Anatomy and Cell Biology and Department of Ophthalmology, University of Kansas Medical Center, Kansas City, KS

Flagellar assembly and function depend on cargo traveling via motors on microtubule doublets. Bertiaux, Mallet et al. (2018. Read More

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December 2018
1 Read

Mental disorders associated with recent cancer diagnosis: Results from a nationally representative survey.

Eur J Cancer 2018 Dec 30;105:10-18. Epub 2018 Oct 30.

AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, France; INSERM U894, Institute of Psychiatry and Neurosciences of Paris, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Faculty of Medicine, Paris, France.

Background: Receiving a diagnosis of cancer may be associated with increased risk of mental disorders. Yet, in this context, no factor predicts the onset of a mental disorder besides the diagnosis of cancer itself. If patients with a history of mental disorder are at particular risk is unknown. Read More

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December 2018
2 Reads

Immune Functional Assays, From Custom to Standardized Tests for Precision Medicine.

Front Immunol 2018 16;9:2367. Epub 2018 Oct 16.

EA7426 Pathophysiology of Injury-Induced Immunosuppression, Université Claude Bernard Lyon 1-Hospices Civils de Lyon-bioMérieux, Lyon, France.

The immune response is a dynamic system that maintains the integrity of the body, and more specifically fight against infections. However, an unbalanced host immune response is highlighted in many diseases. Exacerbated responses lead to autoimmune and allergic diseases, whereas, low or inefficient responses favor opportunistic infections and viral reactivations. Read More

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October 2018
6 Reads

Interactive Effects of Pesticides and Nutrients on Microbial Communities Responsible of Litter Decomposition in Streams.

Front Microbiol 2018 17;9:2437. Epub 2018 Oct 17.

Laboratoire Microorganismes: Génome et Environnement, CNRS, Université Clermont Auvergne, Clermont-Ferrand, France.

Global contamination of streams by a large variety of compounds, such as nutrients and pesticides, may exert a high pressure on aquatic organisms, including microbial communities and their activity of organic matter decomposition. In this study, we assessed the potential interaction between nutrients and a fungicide and herbicide [tebuconazole (TBZ) and S-metolachlor (S-Met), respectively] at realistic environmental concentrations on the structure (biomass, diversity) and decomposition activity of fungal and bacterial communities (leaf decay rates, extracellular enzymatic activities) associated with () leaves. A 40-day microcosm experiment was used to combine two nutrient conditions (mesotrophic and eutrophic) with four pesticide treatments at a nominal concentrations of 15 μg L (control, TBZ and S-Met, alone or mixed) following a 2 × 4 full factorial design. Read More

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October 2018

Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting.

Nat Commun 2018 10 25;9(1):4450. Epub 2018 Oct 25.

Pathogenesis of Vascular Infections Unit, INSERM, Institut Pasteur, Paris, 75015, France.

The shape of cellular membranes is highly regulated by a set of conserved mechanisms that can be manipulated by bacterial pathogens to infect cells. Remodeling of the plasma membrane of endothelial cells by the bacterium Neisseria meningitidis is thought to be essential during the blood phase of meningococcal infection, but the underlying mechanisms are unclear. Here we show that plasma membrane remodeling occurs independently of F-actin, along meningococcal type IV pili fibers, by a physical mechanism that we term 'one-dimensional' membrane wetting. Read More

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October 2018
4 Reads

Stimulation or inhibition: Leaf microbial decomposition in streams subjected to complex chemical contamination.

Sci Total Environ 2019 Jan 17;648:1371-1383. Epub 2018 Aug 17.

Université Clermont-Auvergne, CNRS, Laboratoire Microorganismes: Génome et Environnement, F-63000 Clermont-Ferrand, France.

Leaf litter decomposition is a key mechanism in headwater streams, allowing the transfer of nutrients and energy into the entire food web. However, chemical contamination resulting from human activity may exert a high pressure on the process, possibly threatening the structure of heterotrophic microbial communities and their decomposition abilities. In this study, the rates of microbial Alnus glutinosa (Alnus) leaf decay were assessed in six French watersheds displaying different land use (agricultural, urbanized, forested) and over four seasons (spring, summer, autumn, winter). Read More

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January 2019

An 11-year-old with mallet finger.

Emerg Med J 2018 Nov;35(11):679-680

Department of Emergency Medicine, University Hospital Waterford, Waterford, Ireland.

An 11-year-old girl presented with pain and deformity in her right little finger distal interphalangeal joint (DIPJ). She was active in several sports including hurling and had a history of dyspraxia with frequent minor soft tissue injuries which had not required hospital assessment. Her mother was concerned about the possibility of a recent injury. Read More

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November 2018
5 Reads

Current Perspectives on High-Throughput Sequencing (HTS) for Adventitious Virus Detection: Upstream Sample Processing and Library Preparation.

Viruses 2018 10 16;10(10). Epub 2018 Oct 16.

Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.

A key step for broad viral detection using high-throughput sequencing (HTS) is optimizing the sample preparation strategy for extracting viral-specific nucleic acids since viral genomes are diverse: They can be single-stranded or double-stranded RNA or DNA, and can vary from a few thousand bases to over millions of bases, which might introduce biases during nucleic acid extraction. In addition, viral particles can be enveloped or non-enveloped with variable resistance to pre-treatment, which may influence their susceptibility to extraction procedures. Since the identity of the potential adventitious agents is unknown prior to their detection, efficient sample preparation should be unbiased toward all different viral types in order to maximize the probability of detecting any potential adventitious viruses using HTS. Read More

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October 2018
12 Reads

[The 10-year findings from the FondaMental Academic Center of Expertise for Schizophrenia (FACE-SZ): Review and recommendations for clinical practice].

Encephale 2018 Oct 13. Epub 2018 Oct 13.

Fondation FondaMental, 94000 Créteil, France; EA 7280 faculté de médecine, université d'Auvergne, CHU, CMP B, BP 69, 63003 Clermont-Ferrand cedex 1, France.

Objectives: The present article is a synthesis of the first 10 years of follow-up of the FondaMental Academic Center of Expertise for Schizophrenia (FACE-SZ) cohort.

Methods: More than 700 community-dwelling stabilized subjects have been recruited and evaluated to date. The mean age was 32 years with 75 % males, the mean illness duration was 11 years, the mean age at illness onset was 21 years, the mean duration of untreated psychosis was 1. Read More

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October 2018
2 Reads

Claw toe.

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:126

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

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October 2018
2 Reads

Comparison of Surgical Outcome after Impacted Third Molar Surgery Using Piezotome and a Conventional Rotary Handpiece.

Contemp Clin Dent 2018 Sep;9(Suppl 2):S318-S324

Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Mangalore, Karnataka, India.

Background And Aim: One of the most commonly performed surgical procedures by oral and maxillofacial surgeons all over the world is the removal of impacted teeth. The most critical and important steps in third molar extraction are bone cutting or osteotomy. Many techniques are used for this purpose including chisels and mallet, rotary instruments, and ultrasonic-based bone cutting instruments. Read More

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September 2018
1 Read

Oral health and microbiota status in professional rugby players: A case-control study.

J Dent 2018 Dec 5;79:53-60. Epub 2018 Oct 5.

INSERM U1048, F-31432 Toulouse, France, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), F-31432 Toulouse, France; Université Paul Sabatier III (UPS), F-31432 Toulouse, France; CHU Toulouse, Service d'Odontologie Toulouse, F-3100, France. Electronic address:

Objective: Elite athletes are prone to develop oral diseases, which could increase the risk for injuries. The aim of this study was to evaluate the oral health and the composition of oral microbiota of elite rugby players compared to the general population.

Methods: We set up a case-control study by screening 24 professional rugby players (PRG) and 22 control patients (CG) for dental and gingival examinations and performed a taxonomic analysis and a predicted functional analysis of oral microbiota. Read More

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December 2018
3 Reads

Incidence of grade 3-4 liver injury under immune checkpoints inhibitors: A retrospective study.

J Hepatol 2018 Dec 3;69(6):1396-1397. Epub 2018 Oct 3.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Cochin, Hepatology Service, France; Institut Pasteur, Inserm, Unité 1223, Paris, France. Electronic address:

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December 2018
1 Read

Tobacco Smoking and Psychotic-Like Experiences in a General Population Sample.

J Clin Psychiatry 2018 Oct 2;79(6). Epub 2018 Oct 2.

AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, France.

Objective: Recent findings suggest an association between tobacco and psychosis, but whether this association is mediated by confounding factors is unknown. Psychosis-like experiences (PLEs) are a subclinical expression of psychosis. To disentangle the association of tobacco with PLEs, we examined data from a large US population-based, nationally representative sample. Read More

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October 2018
12 Reads

Brain metabolism and related connectivity in patients with acrophobia treated by virtual reality therapy: an F-FDG PET pilot study sensitized by virtual exposure.

EJNMMI Res 2018 Oct 1;8(1):93. Epub 2018 Oct 1.

Aix-Marseille Université, CNRS, Ecole Centrale Marseille, UMR 7249, Institut Fresnel, Marseille, France.

Background: The aim of this pilot study is to investigate the impact of virtual reality exposure therapy (VRET) on brain metabolism and connectivity. Eighteen patients with acrophobia were assessed by an F-FDG PET scan sensitized by virtual exposure before treatment, and nine of them were assessed again after eight sessions of VRET. Statistical Parametric Mapping was used to study the correlations between metabolism and pretherapeutic clinical scores and to compare metabolism before and after VRET (p voxel < 0. Read More

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October 2018
5 Reads

Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum.

J Cell Biol 2018 Dec 1;217(12):4284-4297. Epub 2018 Oct 1.

Trypanosome Cell Biology Unit, INSERM U1201, Institut Pasteur, Paris, France

Intraflagellar transport (IFT) is the rapid bidirectional movement of large protein complexes driven by kinesin and dynein motors along microtubule doublets of cilia and flagella. In this study, we used a combination of high-resolution electron and light microscopy to investigate how and where these IFT trains move within the flagellum of the protist Focused ion beam scanning electron microscopy (FIB-SEM) analysis of trypanosomes showed that trains are found almost exclusively along two sets of doublets (3-4 and 7-8) and distribute in two categories according to their length. High-resolution live imaging of cells expressing mNeonGreen::IFT81 or GFP::IFT52 revealed for the first time IFT trafficking on two parallel lines within the flagellum. Read More

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December 2018
12 Reads

Metabolic Syndrome and Illness Severity Predict Relapse at 1-Year Follow-Up in Schizophrenia: The FACE-SZ Cohort.

J Clin Psychiatry 2018 Sep 18;79(6). Epub 2018 Sep 18.

FondaMental Fondation, Créteil, France.

Objective: Predicting relapse is a major challenge in schizophrenia from a clinical and medico-economic point of view. During recent decades, major psychiatric disorders have been found to be extensively associated with metabolic disorders, even before the illness onset, with a prevalence estimated to be 35% in this population. However, no study to date has, to our knowledge, explored the potential impact of metabolic syndrome (MetS) on relapse. Read More

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September 2018
8 Reads
5.500 Impact Factor

Assessment of Metacognition and Reversal Learning in Parkinson's Disease: Preliminary Results.

Front Hum Neurosci 2018 11;12:343. Epub 2018 Sep 11.

Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Reversal learning (RL) has been widely used for assessment of behavioral adaptation, impulsivity, obsession, and compulsion in healthy controls as well as people suffering from psychiatric and neurological disorders such as Parkinson's disease (PD). Nevertheless, studies addressing high cognitive functions such as metacognition in PD are scarce. Here, we address for the first time the effect of levodopa and PD on metacognition within the framework of a RL paradigm. Read More

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September 2018
7 Reads

Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

Psychiatry Res 2018 Dec 13;270:104-110. Epub 2018 Sep 13.

Fondation FondaMental, Créteil, France; CMP B, CHU, EA 7280 Faculté de Médecine, Université d'Auvergne, BP 69 63003, Clermont-Ferrand Cedex 1, France.

Objective: Hypovitaminosis D has been associated with respectively major depressive disorder, schizophrenia (SZ) and cognitive disorders in the general population, and with positive and negative symptoms and metabolic syndrome in schizophrenia. The objectives were (i) to determine the prevalence of hypovitaminosis D and associated factors (with a focus on depression and cognition) in a national non-selected multicentric sample of community-dwelling SZ subjects (ii) to determine the rate of SZ patients being administered vitamin D supplementation and associated factors.

Methods: A comprehensive 2 daylong clinical and neuropsychological battery was administered in 140 SZ subjects included between 2015 and 2017 in the national FondaMental Expert Center (FACE-SZ) Cohort. Read More

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December 2018
9 Reads

[Caregivers faced with painful events, testimonials].

Soins Pediatr Pueric 2018 Sep - Oct;39(304):34-36

Hôpital Raymond Poincaré, AP-HP, 104 boulevard Raymond-Poincaré, 92380 Garches, France.

Whatever the profession of caregivers, their activity involves supporting patients and families who are suffering. Doctors and nurses, in particular, talk of the strong emotions which they feel but which they find difficult to express. Being aware of them is essential for being able to accept them and limit their consequences. Read More

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September 2018
1 Read

Kinematic differences between children with obstetric brachial plexus palsy and healthy controls while performing activities of daily living.

Clin Biomech (Bristol, Avon) 2018 Nov 5;59:143-151. Epub 2018 Sep 5.

Royal College of Surgeons, 123 St Stephen's Green, Dublin 2, Ireland.

Background: Residual shoulder dysfunction and deformity impacts on functional performance in children with obstetric brachial plexus palsy. Clinical understanding of upper limb dynamic movement patterns is difficult with observation alone. This case-control study describes the significant kinematic differences between children with obstetric brachial plexus palsy compared to typically developing children while performing tasks of the modified Mallet Scale. Read More

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November 2018

Performance analysis of automated evaluation of antinuclear antibody indirect immunofluorescent tests in a routine setting.

Auto Immun Highlights 2018 Sep 21;9(1). Epub 2018 Sep 21.

Central Diagnostic Laboratory, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

Purpose: Indirect immunofluorescence (IIF) on the human epithelial cell-line HEp-2 (or derivatives) serves as the gold standard in antinuclear antibody (ANA) screening. IIF, and its evaluation, is a labor-intensive method, making ANA testing a major challenge for present clinical laboratories. Nowadays, several automated ANA pattern recognition systems are on the market. Read More

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September 2018
8 Reads

Aberrant Splicing Is the Pathogenicity Mechanism of the p.Glu314Lys Variant in Gene.

Front Endocrinol (Lausanne) 2018 5;9:491. Epub 2018 Sep 5.

Laboratoire de Biochimie et Biologie Moléculaire Grand Est, UM Pathologies Endocriniennes Rénales Musculaires et Mucoviscidose, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France.

The cholesterol side chain cleavage enzyme (CYP11A1) catalyzes the conversion of cholesterol to pregnenolone, the first rate-limiting step of steroidogenesis. mutations are associated with primary adrenal insufficiency (PAI) as well as disorders of sex development (DSD) in 46,XY patients. To define the pathogenicity mechanism for the p. Read More

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September 2018
1 Read

Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013-2016.

Emerg Infect Dis 2018 Oct;24(10):1850-1858

Congenital Zika virus syndrome consists of a large spectrum of neurologic abnormalities seen in infants infected with Zika virus in utero. However, little is known about the effects of Zika virus intrauterine infection on the neurocognitive development of children born without birth defects. Using a case-control study design, we investigated the temporal association of a cluster of congenital defects with Zika virus infection. Read More

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October 2018
1 Read

Loss of Midline Function in Brachial Plexus Birth Palsy Patients.

J Pediatr Orthop 2018 Sep 11. Epub 2018 Sep 11.

Shriners Hospital for Children, Philadelphia, PA.

Background: Loss of midline function impairs the child's ability to perform certain activities of daily living such as dressing, buttoning, and perineal care. The purpose of this study was to assess brachial plexus birth palsy (BPBP) patients with loss of midline function with respect to etiology and treatment.

Methods: A retrospective review of all BPBP patients with loss of midline function was performed. Read More

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September 2018
12 Reads

Arthroscopic versus open release of internal rotation contracture in the obstetrical brachial plexus paralysis (OBPP) sequela.

J Shoulder Elbow Surg 2018 Sep 6. Epub 2018 Sep 6.

Department of Orthopaedic Surgery and Traumatology, School of Medicine, Koç University, Istanbul, Turkey.

Background: Latissimus dorsi (LD) and teres major (TM) tendon transfers are effective surgical procedures to improve shoulder abduction and external rotation for children with obstetrical brachial plexus palsy (OBPP). Open pectoralis major (PM) tendon Z-plasty and arthroscopic subscapularis (SS) release are 2 options for the release of internal rotation contractures to enhance muscle transfers. This study compared the functional results of LD and TM tendon transfers with open PM tendon Z-plasty or arthroscopic SS release. Read More

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September 2018
6 Reads

Bone and joint infections in infants under three months of age.

Acta Paediatr 2018 Sep 6. Epub 2018 Sep 6.

Paediatric Department-Division of infectious disease, Armand Trousseau Hospital, AP-HP, Paris, France.

Aim: Studies on bone and joint infections (BJI) in infants under three months are rare. We described the clinical and paraclinical features and outcomes of infants hospitalised with BJI under three months of age.

Methods: The French National Hospital Discharge Database provided data on BJIs in infants under three months of age from January 2004 to 2015 in three Parisian Paediatric teaching hospitals. Read More

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September 2018
6 Reads

Combined diffusion tensor imaging and magnetic resonance spectroscopy to predict neurological outcome before transjugular intrahepatic portosystemic shunt.

Aliment Pharmacol Ther 2018 Oct 4;48(8):863-874. Epub 2018 Sep 4.

Brain-Liver Pitié-Salpêtrière Study Group (BLIPS), Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Paris, France.

Background: Hepatic encephalopathy (HE) may occur after transjugular intrahepatic portosystemic shunt (TIPSS) placement. Multimodal magnetic resonance imaging (MRI), combining anatomical sequences, diffusion tensor imaging (DTI) and H magnetic resonance spectroscopy, is modified in cirrhotic patients.

Aims: To describe multimodal MRI images before TIPSS, to assess if TIPSS induces changes in multimodal MRI, and to find predictors of HE after TIPSS in patients with cirrhosis. Read More

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October 2018
2 Reads

BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer.

J Exp Clin Cancer Res 2018 Aug 30;37(1):209. Epub 2018 Aug 30.

Univ. Grenoble Alpes, Inserm, CEA, BIG-Biologie du Cancer et de l'Infection, 38000, Grenoble, France.

Background: Angiogenesis has become an attractive target for cancer therapy. However, despite the initial success of anti-VEGF (Vascular endothelial growth factor) therapies, the overall survival appears only modestly improved and resistance to therapy often develops. Other anti-angiogenic targets are thus urgently needed. Read More

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August 2018
1 Read

Sex differences in the peripheral and central immune responses following lipopolysaccharide treatment in pubertal and adult CD-1 mice.

Int J Dev Neurosci 2018 Dec 27;71:94-104. Epub 2018 Aug 27.

School of Psychology, Faculty of Social Sciences, University of Ottawa, Canada. Electronic address:

Puberty is a critical developmental period that is characterized by significant brain development. Exposure to stress during this time can alter brain functioning setting the stage for long-lasting behavioural outcomes. The objective of this study was to investigate age and sex differences in the peripheral and central immune responses, along with sickness behaviour, following immune stress. Read More

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December 2018
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Inter-kingdom effect on epithelial cells of the N-Acyl homoserine lactone 3-oxo-C12:2, a major quorum-sensing molecule from gut microbiota.

PLoS One 2018 29;13(8):e0202587. Epub 2018 Aug 29.

Sorbonne Université, École normale supérieure, PSL University, CNRS, INSERM, APHP, Hôpital Saint-Antoine, Laboratoire des biomolécules, LBM, Paris, France.

Background And Aims: N-acyl homoserine lactones (AHLs), which are autoinducer quorum-sensing molecules involved in the bacterial communication network, also interact with eukaryotic cells. Searching for these molecules in the context of inflammatory bowel disease (IBD) is appealing. The aims of our study were to look for AHL molecules in faecal samples from healthy subjects (HS) and IBD patients to correlate AHL profiles with the microbiome and investigate the effect of AHLs of interest on epithelial cells. Read More

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August 2018
6 Reads
3.230 Impact Factor

Does Staphylococcus aureus nasal decontamination affect the rate of early surgical site infection in adolescent idiopathic scoliosis surgery?

Eur Spine J 2018 Oct 25;27(10):2543-2549. Epub 2018 Aug 25.

Pediatric Orthopedic Department, Robert Debré University Hospital, Paris Diderot University, 48 Boulevard Sérurier, 75019, Paris, France.

Purpose: Surgical site infection (SSI) is a main complication after adolescent idiopathic scoliosis (AIS) surgery. Nasal colonization with S. aureus is a known risk factor for developing nosocomial infections in cardiac surgery. Read More

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October 2018
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Effects of the Use of a Mallet during Bone Marrow Biopsy Collection on Specimen Quality: A Quality Improvement Project.

Ann Clin Lab Sci 2018 Jul;48(4):517-521

Department of Pathology and Laboratory Medicine, University of Texas McGovern Medical School at Houston, Houston, Texas, USA

Context: Avoiding procedure-related morphologic distortion such as fragmentation and crush artifact is critical in bone marrow diagnosis. Use of a hammer or mallet, although infrequent, is a known technique of advancing the biopsy needle during specimen collection.

Objectives: We performed a double-blinded, retrospective review of bone marrow biopsies collected by the Interventional Radiology department at our institution in order to assess specimen quality by using this technique. Read More

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July 2018
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Dermatological manifestations in cardiofaciocutaneous syndrome: a prospective multicentric study of 45 mutation-positive patients.

Br J Dermatol 2018 Aug 23. Epub 2018 Aug 23.

Department of Clinical Genetics, Arnaud de Villeneuve Hospital, University of Montpellier, Montpellier, France.

Background: Data on dermatological manifestations of cardiofaciocutaneous syndrome (CFCS) remain heterogeneous and almost without expert dermatological classification.

Objectives: To describe the dermatological manifestations of CFCS; to compare them with the literature findings; to assess those discriminating CFCS from other RASopathies, including Noonan syndrome (NS) and Costello syndrome (CS); and to test for dermatological phenotype-genotype correlations.

Methods: We performed a 4-year, large, prospective, multicentric, collaborative dermatological and genetic study. Read More

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August 2018
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