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Acta Med Port 2020 Mar 2;33(3):198-201. Epub 2020 Mar 2.

Department of Gynaecology. Hospital and University Centre of Coimbra. Coimbra. Department of Gynaecology. Faculty of Medicine. University of Coimbra. Coimbra. Portugal.

Introduction: Human papillomavirus is responsible for almost all cases of cervical cancer, an important portion of anogenital and oropharyngeal invasive and preinvasive lesions, as well as genital warts (condyloma acuminatum) and recurrent respiratory papillomatosis. Currently, three prophylactic vaccines against high-risk Human papillomavirus are commercialized in many countries worldwide.

Methods: To this non-systematic review the authors searched in MEDLINE/PubMed for systematic reviews, meta-analysis and randomized controlled trials, published in the last six years, using the terms "HPV", "non-cervical cancer" and "vaccine". Read More

Pathol Res Pract 2020 Apr 12;216(4):152865. Epub 2020 Feb 12.

Department of Pathology, North Hospital, University Hospital of St-Etienne, France.

Background: Granular cell tumor (GCT) remains a diagnostic clinicopathologic problem because the exact frequency of its detailed morphological and clinical characteristics is unknown as most observations are collected from small series or isolated cases. Herein, our aim is to highlight the frequency of all clinicopathological characteristics of this rare tumor based in our series and the available medical (PubMed) literature.

Material And Methods: 42 cases were evaluated for: tissue layers involved by the tumor (in skin and mucosae), growth pattern, nuclear pleomorphism, mitotic index, necrosis, spindling, calcification, hyalinization, and pustule-ovoid bodies of Milian, as well as perineural and vascular invasion, and the presence of adjacent epithelium changes, and lymphocytes and eosinophils infiltration. Read More

Gynecol Oncol 2020 Mar 9;156(3):734-743. Epub 2020 Jan 9.

Centre for Human Drug Research, Zernikedreef 8, 2333CL Leiden, the Netherlands; Department of Gynecology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands. Electronic address:

Introduction: Vulvar squamous cell carcinoma (VSCC) is a rare malignancy with an increasing incidence, especially in young women. Surgical treatment of VSCC is associated with significant morbidity and high recurrence rates, which is related to the limited ability to distinguish (pre)malignant from healthy tissue. There is a need for new tools for specific real-time detection of occult tumor lesions and localization of cancer margins in patients with VSCC. Read More

Mod Pathol 2020 Jan 2. Epub 2020 Jan 2.

Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Department of Oral and Maxillofacial Surgery/Oral Pathology, Cancer Center Amsterdam, de Boelelaan, 1117, Amsterdam, The Netherlands.

Oral leukoplakia is the most common oral potentially malignant disorder with a malignant transformation rate into oral squamous cell carcinoma of 1-3% annually. The presence and grade of World Health Organization defined dysplasia is an important histological marker to assess the risk for malignant transformation, but is not sufficiently accurate to personalize treatment and surveillance. Differentiated dysplasia, known from differentiated vulvar intraepithelial neoplasia, is hitherto not used in oral dysplasia grading. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Dec;51(6):1182-1184

Department of Rheumatology and Immunology, Shanxi Bethune Hospital, Taiyuan 030032, China.

A 61-year-old woman was referred to our department with a 11-year-erythra. In the anterior tibia of both lower extremities, we could see large dark red infiltrating erythema, waxy luster, clear boundary, slight central atrophy, depression and capillary dilatation. He was diagnosed with "dermatitis contusiformis" in local hospitals, but the treatment of traditional Chinese medicine and external drugs was not effective. Read More

World J Clin Cases 2019 Nov;7(21):3671-3682

Department of Pediatric Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.

Background: Primitive neuroectodermal tumors are rare, highly malignant small round cell tumors belonging to the Ewing sarcoma family. The purpose of this article is to present clinical manifestation, histology, treatment, and prognosis of two primitive neuroectodermal tumors (PNETs) in extremely rare anatomic locations, the abdominal wall and vulva.

Case Summary: Case 1 was a 66-month-old girl with lesions on the abdominal wall; tumor size was about 3. Read More

Acta Dermatovenerol Croat 2019 Sep;27(3):195-197

Ivana Škrinjar, MD, Department of Oral Medicine, University Hospital Center Zagreb, Gundulićeva 5, 10000 Zagreb, Croatia;

Lichen sclerosus (LS) is a chronic, inflammatory, mucocutaneous disorder of genital and extragenital skin (1). Simultaneous involvement of the oral mucosa is extremely rare, but it may be the only affected area (2). A 55-year-old woman was referred to the Department of Oral Medicine, School of Dental Medicine University of Zagreb due to whitish lesions on the right ventrolateral part of the tongue and buccal mucosa with desquamative gingivitis (Figure 1, a-c). Read More

Vet World 2019 Jun 11;12(6):778-782. Epub 2019 Jun 11.

Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Aims: This study aimed to provide a summary of all online available literature of published clinical and histopathological data regarding tumors affecting the reproductive tract of female sheep and goats. In addition, a detailed description of the clinical history, clinical findings, and gross and histopathological findings of one case of vaginal fibroma in an adult Awassi sheep is provided for the first time.

Materials And Methods: Internet search engines such as PubMed, ResearchGate, Scopus, ScienceDirect, and Google Scholar were used to collect all published articles in refereed journals from 2000 to 2018 regarding tumors and tumor-like lesions involving the reproductive tract of ewes and does. Read More

J Am Acad Dermatol 2019 Aug 19. Epub 2019 Aug 19.

Department of Dermatology, MedStar Washington Hospital Center, Washington, DC. Electronic address:

The prevalence of acute vulvovaginal involvement in toxic epidermal necrolysis may be as high as 70%; up to 28% of females will also develop chronic vulvovaginal sequelae. There is little consensus regarding prevention and treatment of the gynecological sequelae of both Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). We review acute and chronic sequelae including erosions, scar formation, chronic skin changes, urethral complications, adenosis and malignant transformation, vulvodynia and dyspareunia. Read More

J Obstet Gynaecol Can 2019 Aug;41(8):1221-1234

Winnipeg, MB (GOC).

Objective: The primary objective of this document is to clarify the indications for pelvic examination.

Intended Users: Physicians, including gynaecologists, obstetricians, family physicians, and emergency physicians; nurses, including registered nurses and nurse practitioners; midwives, including midwives in clinical practice and midwifery trainees; medical trainees, including medical students, residents, and fellows; and all other health care providers who care for women.

Target Population: This publication provides evidence and expert-based recommendations for pelvic examination in adult women (18 years and older) both with and without gynaecologic symptoms. Read More

Pan Afr Med J 2018 3;31:76. Epub 2018 Oct 3.

Service de Gynécologie Obstétrique, Centre Hospitalo-Universitaire Fattouma Bourguiba de Monastir, Rue du 1 Juin 1955, Monastir 5000, Tunisie.

We here report the case of a 58-year old nulliparous patient with a history of Niemann-Pick disease who presented with vulvoperineal, fluctuant, fistulized swelling measuring 10 cm associated with ulceration. The patient was febrile with impaired general state This mass caused some concern about necrotic and infected malignant tumor of the vulva associated with chronic dermatosis. Incision and purulent drainage associated with multiple biopsies excluded the presence of a neoplastic process. Read More

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):127-130

Department of Gynecology and Obstetrics, Clinical Hospital, Tetovo, Republic of Macedonia.

Fibroepithelial stromal polyps of vulva are the type of mesenchymal lesion that typically occurs in women of reproductive period. They are common, usually small and hystologically benign. Larger lesions are rare and likely arise from proliferation of mesenchymal cells within the hormonally sensitive subepithelial stromal layer of the lower genital tract. Read More

Acta Cytol 2019 13;63(2):97-99. Epub 2018 Dec 13.

Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil,

Papillomaviruses (PVs) are a group of small DNA viruses that, with around 350 million years of evolution, acquired the capacity of infecting a broad range of vertebrates, including humans. To date, more than 300 PV types have been isolated. Viruses that have a long common evolutionary history with their host typically cause unapparent infections. Read More

Int J Urol 2019 03 3;26(3):353-357. Epub 2018 Dec 3.

Department of Urology, University Medical Center Utrecht, Utrecht, the Netherlands.

Objective: To determine the incidence of penile intraepithelial neoplasia in the Netherlands using a nationwide histopathology registry and to discuss the nomenclature of premalignant penile lesions.

Methods: Data from patients in the Netherlands diagnosed with a premalignant penile lesion between January 1998 and December 2007 were collected from the nationwide histopathology registry (PALGA); this database covers all pathology reports of inhabitants in the Netherlands. The premalignant lesions included were erythroplasia of Queyrat; Bowen's disease; bowenoid papulosis; mild, moderate and severe dysplasia; and carcinoma in situ of the penis. Read More

Int J STD AIDS 2019 02 4;30(2):198-200. Epub 2018 Oct 4.

3 Department of GU Medicine, Solent NHS Trust, Southampton, UK.

Organ transplant recipients are at a higher risk of pre-malignant human papillomavirus-associated lesions due to immunosuppression. The efficacy of immunomodulants such as imiquimod 5% is not yet fully evaluated in this population. We describe a case of vulval intra-epithelial neoplasia in a renal transplant recipient which was successfully treated with topical imiquimod. Read More

Int J Gynecol Cancer 2018 11;28(9):1728-1736

Department of Plastic Surgery.

Objective: Resection of (pre) malignant lesions in the vulvoperineal area may result in large defects that cannot be closed primarily. The lotus petal flap technique is widely used for reconstruction. The aim of this study was to evaluate both quality of life (QoL) and sexual functioning of patients who underwent the lotus petal flap procedure, because no data are available on this topic. Read More

Ann Diagn Pathol 2018 Oct 30;36:38-43. Epub 2018 Jun 30.

Weill Cornell Medical College, Department of Pathology and Laboratory Medicine, 1300 York Ave, New York, NY 10065, United States of America. Electronic address:

Low-grade endometrial stromal sarcoma (LGESS) is the second most common malignant mesenchymal tumor of the uterus. The most common location is the uterine corpus, but it can also primarily arise in a variety of extrauterine locations such as pelvis, ovary, abdominal cavity, vagina, and vulva. We are reporting a case of a 47-year-old female with no significant medical history who presented with multiple pulmonary nodules. Read More

J Eur Acad Dermatol Venereol 2019 Jan 12;33(1):84-92. Epub 2018 Jul 12.

Dermatology Department, Centre Hospitalier de Lyon Sud, Hospices civils de Lyon, Université Claude Bernard Lyon 1, Pierre Bénite, France.

Background: Vulvar melanosis can occasionally be clinically challenging by mimicking an early melanoma.

Objective: To report our experience of initial evaluation and follow-up in this peculiar subset of vulvar melanosis using reflectance confocal microscopy (RCM).

Methods: We retrospectively evaluated 18 consecutive cases referred for atypical vulvar pigmentation or for which melanoma was considered and that underwent both RCM examination and histopathological assessment. Read More

Ann Plast Surg 2018 Jun;80(6):648-652

Gynecologic Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

Background And Aim: Because of the associated high recurrence rate, future reconstructive options should be reckoned with during surgical treatment of primary or recurrent (pre)malignant vulvoperineal lesions. One of the claimed advantages of the gluteal fold flap is the possibility of repeated use of the flap in case of recurrence. We present our experience with such reuse of gluteal fold flaps to illustrate this possibility. Read More

Open Access Maced J Med Sci 2018 Jan 13;6(1):110-111. Epub 2018 Jan 13.

"Onkoderma"- Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.

Condyloma acuminata represents an epidermal manifestation, associated with the epidermotropic human papillomavirus (HPV). They have been reported as the most common sexually transmitted disease, with prevalence exceeding 50%, increased up to 4 times, within the last two decades, as the most common side of affection are the penis, vulva, vagina, cervix, perineum, and perianal area, with increased prevalence in young, sexually active individuals. Increased attention should be focused on lesions, caused by types, with moderate (33, 35, 39, 40, 43, 45, 51-56, 58) or high risk potential (types 16, 18) for malignant transformation, leading to further development of cancers of anus, vagina, vulva and penis, as well as cancers of the head and neck. Read More

Rev Bras Ginecol Obstet 2018 Mar 23;40(3):163-167. Epub 2018 Feb 23.

Faculdade de Medicina, Universidade do Oeste Paulista, Presidente Prudente, São Paulo, Brazil.

Melanomas of the female genital tract may occur in the vulva, the vagina, the ovary or the cervix. Pregnancy has been considered an aggravating factor in the evolution and prognosis of melanoma. A 35-year-old female presented with vaginal bleeding 2 months after a term cesarean delivery. Read More

J Pediatr Adolesc Gynecol 2018 Jun 3;31(3):311-314. Epub 2018 Jan 3.

Department of Gynecology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts.

Background: Granular cell tumors (GCTs) are rare soft tissue lesions that can involve the female genital tract, including the vulva. Although malignant tumors are aggressive and uncommon, benign and atypical lesions still have associated risks, including recurrence and multisite development.

Cases: Four cases of pediatric vulvar GCT are presented, including 1 atypical and 3 benign tumors. Read More

Gynecol Oncol 2018 02 21;148(2):430-431. Epub 2017 Dec 21.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: Melanomas of the vulva and vagina are rare, and surgery is the gold standard of treatment [1, 2]. Since recent studies have reported pelvic exenteration by using robotic surgical system [3, 4], we showed the surgical procedures of robot-assisted anterior pelvic exenteration (rAPE) with ileal conduit urinary diversion for vulvovaginal malignant melanoma.

Methods: A 55-year-old woman who received vaginal wall resection due to vaginal malignant melanoma 8months before was referred. Read More

Eur J Nucl Med Mol Imaging 2018 04 21;45(4):622-629. Epub 2017 Nov 21.

Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, D-45147, Essen, Germany.

Purpose: To evaluate the diagnostic performance of F-FDG PET/MRI for whole-body staging and potential changes in therapeutic management of women with suspected recurrent pelvic cancer in comparison with MRI alone.

Methods: Seventy-one consecutive women (54 ± 13 years, range: 25-80 years) with suspected recurrence of cervical (32), ovarian (26), endometrial (7), vulvar (4), and vaginal (2) cancer underwent PET/MRI including a diagnostic contrast-enhanced MRI protocol. PET/MRI and MRI datasets were separately evaluated regarding lesion count, localization, categorization (benign/malignant), and diagnostic confidence (3-point scale; 1-3) by two physicians. Read More

Histopathology 2018 Apr 26;72(5):749-759. Epub 2018 Jan 26.

Division of Women's & Perinatal Pathology, Department of Pathology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

Aims: Solitary fibrous tumour (SFT) is an uncommon spindle cell neoplasm of fibroblastic origin, first described as a tumour of the pleura and now well established at extrapleural sites. However, SFT in the female genital tract is rare and therefore not fully characterised. Here, we describe a series of 25 SFTs arising throughout the gynaecological tract, including the vulva (14 cases), vagina (one), cervix (one), uterus (six), ovary (two), and fallopian tube (one). Read More

Oncol Lett 2017 Oct 26;14(4):4282-4286. Epub 2017 Jul 26.

Department of Radiation-Oncology, Tumor Hospital of Jilin, Changchun, Jilin 130000, P.R. China.

Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare and malignant form of lung cancer with a poor prognosis for patients. The common sites of metastases are the liver, adrenal glands, bone and brain. LCNEC rarely metastasizes to the small intestine, ovaries, tonsils, mandible, vulva or spine. Read More

Front Biosci (Elite Ed) 2018 Jan 1;10:15-73. Epub 2018 Jan 1.

Molecular Oncology Laboratory, Department of Zoology, University of Delhi, Delhi 110007, India.

Human papillomavirus (HPV) infection is linked to development of cancer of cervix, vagina, vulva, penis, ano-genital and non-genital oro-pharyngeal sites. HPV being a sexually transmitted virus infects both genders equally but with higher chances of pathological outcome in women. In the absence of organized screening programs, women report HPV-infected lesions at relatively advanced stages where they are subjected to standard treatments that are not HPV-specific. Read More

Int J Gynecol Pathol 2018 Nov;37(6):554-558

Department of Pathology and Microbiology (Y.A.T.), University of Nebraska Medical Center, Omaha, Nebraska; Department of Pathology and Laboratory Medicine (Y.A.T., W.D.L., S.E.S.), The Warren Alpert Medical School of Brown University and Women & Infants Hospital, Providence, Rhode Island.

Nodular hyperplasia (NH) of the Bartholin gland is an exceedingly rare benign solid lesion of the female genital tract that can mimic the Bartholin gland cyst clinically. The histologic criteria for NH were established in 1998 by Koenig and Tavassoli. In this case series, we describe 4 cases of NH from Women and Infants Hospital in Rhode Island. Read More

Int Sch Res Notices 2017 25;2017:2414569. Epub 2017 Jul 25.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

Correct and rapid diagnosis of skin tumours often requires biopsy and histopathological examination to differentiate benign lesions such as seborrhoeic keratoses or melanocytic naevi from premalignant and malignant lesions such as malignant melanoma. Particularly, to the untrained eye, any benign skin tumour-pigmented or nonpigmented-is easily mistaken for a malignant lesion. Qualified clinical evaluation is paramount in order to reduce the frequency of unwarranted skin biopsies. Read More

Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352

Bethesda Dermpath Laboratory, 1730 Elton Road, Suite 11, Silver Spring, MD 20903, USA; Anne Arundel Dermatology, Towson, MD 21204, USA; Pathology, Johns Hopkins University, 4940 Bayview Medical Center, Eastern Avenue, Baltimore, MD 21224, USA. Electronic address:

Cutaneous vulvar neoplasms are commonly encountered at gynecology visits, with 2% of women having a benign vulvar melanocytic nevus and 10% to 12% of nevi being vulvar. High-grade squamous intraepithelial lesions (vulvar intraepithelial neoplasia 2 or 3) occurs in 5 per 100,000 women, with increasing incidence in the past 30 years. The recognition of these lesions and differentiation between benign, premalignant, and malignant stages are crucial for adequate diagnosis, clinical monitoring, and treatment. Read More

Curr Urol Rep 2017 Aug;18(8):62

Virginia Mason Medical Center, Seattle, WA, USA.

Purpose Of Review: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic. Read More

Adv Anat Pathol 2017 Jul;24(4):201-214

Departments of *Pathology †Obstetrics and Gynecology, Hospital Clínic ‡Faculty of Medicine, University of Barcelona §ISGlobal, Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain.

Human papillomavirus (HPV) is involved in one of the at least 2 pathways leading to vulvar squamous cell carcinoma (VSCC). Inactivation of p53 and retinoblastoma by the viral products E6 and E7 is involved in malignant transformation. The percentage of HPV-positive VSCCs ranges from 18% to 75%, depending on the geographical area. Read More

Ann Plast Surg 2017 Aug;79(2):186-191

From the *Division of Plastic Surgery, San Gerardo Hospital; and †Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, University of Milano-Bicocca, Monza, Italy.

Vulvoperineal defects after demolitive surgery for preneoplastic or malignant vulvar lesions require a reconstruction to restore good sexual functions and to offer a satisfactory cosmetic result. Several techniques of reconstruction have been described in the past, leading to a more conservative and localized treatment. This study retrospectively reviewed patients with primary or recurrent vulvar malignancies that had undergone vulvoperineal reconstruction between 2010 and 2016 using the V-Y advancement flap and the 2 variant of the lotus petal flap (LPF) in terms of surgical outcome and postoperative complications. Read More

J Obstet Gynaecol Can 2017 Jul 6;39(7):564-566. Epub 2017 May 6.

Sir Sanusi Specialist Hospital, Kano, Nigeria.

Background: Fibro-epithelial polyps are benign soft tissue lesions that occur in a wide variety of sites, including the lower female genital tract. They exhibit a wide range of morphologic appearances and can be misinterpreted as malignant. These polyps therefore pose adiagnostic challenge to both the clinician and the pathologist. Read More

Pathophysiology 2017 Sep 23;24(3):161-167. Epub 2017 Apr 23.

Department of Pathology, North Hospital, University Hospital of St-Etienne, France.

Introduction: Vascular lesions of the female genital tract are extremely rare and their nomenclature does not widely follow the International Society for the Study of Vascular Anomalies (ISSVA) classification.

Aim Of The Study: To describe the clinicopathologic characteristics of vascular lesions of the female genital tract and to apply the ISSVA classification.

Material And Methods: 19 vascular lesions were diagnosed during a 20 year period. Read More

Am J Dermatopathol 2017 May;39(5):358-362

*Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint-Petersburg, Russia; ‡Department of Pathology, Saint-Petersburg Medico-Social Institute, Saint Petersburg, Russia; Departments of §Pathology, and ¶Tumor Growth Biology, Petrov's Research Institute of Oncology, Saint Petersburg, Russia; ‖Department of Medical Genetics, Saint Petersburg Pediatric Medical University, Saint Petersburg, Russia; **Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; and ††Bioptical Laboratory, Pilsen, Czech Republic.

Anogenital mammary-like glands (AGMLGs) are nowadays considered a normal component of the anogenital area. Lesions involving AGMLGs are histopathologically very similar to their mammary counterparts, but the information on molecular biological mechanisms in these vulvar/perianal tumors is scarce. Mutations in the PI3K-AKT cascade have been found in hidradenoma papilliferum. Read More

Case Rep Obstet Gynecol 2017 18;2017:5656340. Epub 2017 Jan 18.

Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama, Japan.

Malignant melanoma (MM) in the female genital tract accounts for less than 2% of all melanomas, and the vast majority associated occur in the vulva and vagina. Primary MM of the uterine cervix is extremely rare and its prognosis is very poor. We report a case of primary MM of the cervix with dissemination throughout the vaginal wall. Read More

Eur J Gynaecol Oncol 2017 ;38(2):308-310

Plasmablastic lymphoma is highly malignant and invasive. It is most commonly found in gastrointestinal tract and is strongly asso- ciated with human immunodeficiency virus (HIV). The authors report a case of a 37-year-old HIV-positive African American woman with a vulvar mass diagnosed as plasmablastic lymphoma. Read More

PLoS One 2016 1;11(12):e0167386. Epub 2016 Dec 1.

Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany.

Introduction: Vaginal intraepithelial neoplasia (VAIN) is a pre-malignant lesion, potentially leading to vaginal cancer. It is a rare disease, representing less than 1% of all intraepithelial neoplasia of the female genital tract. Similar to cervical intraepithelial neoplasia (CIN), there are three different grades of VAIN. Read More

Ceska Gynekol Fall 2016;81(5):369-375

Objective: Overview of current data on HPV infection.

Design: Review article.

Setting: Clinic of Gynecology and Obstetrics, University Hospital in Ostrava, Clinic of Obstetrics and Gynecology, University Hospital in Hradec Králové, Clinic of Gynecology and Obstetrics, General University Hospital in Prague. Read More

Ceska Gynekol Summer 2016;81(3):172-176

This review article discribes the genesis and development of vulvar squamous precancerous lesions terminology and discusses the consensus of the International Society for the Study of Vulvovaginal Disease, the American Society for Colposcopy and Cervical Pathology, College of American Pathologists and the World Health Organization on the current terminology. The article describes the different types of vulvar squamous precancerous lesions, according to their etiology, incidence and malignant potential. Read More

Rev Bras Ginecol Obstet 2016 Sep 27;38(9):471-476. Epub 2016 Oct 27.

Gynecology and Obstetrics Department, Ribeirão Preto Faculty of Medicine, USP, Ribeirão Preto, SP, Brazil.

The Buschke-Loewenstein tumor is characterized by excessive growth of verrucous lesions on the genitals and/or perianal region. It is considered benign despite the high rate of recurrence and the possibility of malignant transformation. It is commonly associated with subtypes 6 and 11 of the human papillomavirus (HPV), and host's immunity plays an important role in the development of the disease. Read More

Indian J Pathol Microbiol 2016 Jul-Sep;59(3):389-91

Department of Pathology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Granular cell tumors (GCTs) are rare and approximately half of the all lesions arise from head and neck, especially from the tongue. However, they are rarely seen in the vulva. They can occur in patients of any age, but peak age incidence is in the fourth to sixth decades. Read More

Eur J Gynaecol Oncol 2016 08;37(4):578-580

Amelanotic malignant melanoma of the vulva is extremely rare. The authors describe here a case of amelanotic malignant melanoma of the vulva, occurring in a 71-year-old woman without any clinical symptoms. The woman had a small nodular lesion in the left labia majora. Read More

Isr Med Assoc J 2016 May;18(5):286-9

Background: Vulvar and vaginal malignant and premalignant lesions are uncommon and are clinically heterogeneous diseases with two pathways of carcinogenesis: human papillomavirus (HPV) induced or non-HPV induced.

Objectives: To evaluate the demographic and clinical characteristics associated with vulvar or vaginal cancer and vulvar and vaginal intraepithelial neoplasia 3 (VIN3, VAIN3).

Methods: We conducted a retrospective chart review of 148 women with vulvar and vaginal malignancy and pre-malignancy for the period October 2004 to October 2012, and identified 59 and 19 patients with vulvar and vaginal cancer respectively, and 57 and 13 patients with VIN3 and VAIN3 respectively

Results: The median age of vulvar cancer patients was 30 years older than that of VIN3 patients. Read More

Int J Mol Sci 2016 Jul 8;17(7). Epub 2016 Jul 8.

Adelaide Proteomics Centre, School of Biological Sciences, The University of Adelaide, Adelaide 5005, Australia.

Vulvar cancer is the fourth most common gynecological cancer worldwide. However, limited studies have been completed on the molecular characterization of vulvar squamous cell carcinoma resulting in a poor understanding of the disease initiation and progression. Analysis and early detection of the precursor lesion of HPV-independent vulvar squamous cell carcinoma (VSCC), differentiated vulvar intraepithelial neoplasia (dVIN), is of great importance given dVIN lesions have a high level of malignant potential. Read More

J Pediatr Adolesc Gynecol 2016 Dec 27;29(6):558-561. Epub 2016 May 27.

Obstetrics and Gynecology, Pediatric Gynecology, University of Calgary, The Alberta Children's Hospital, Calgary, Alberta, Canada.

Study Objective: Clitoral cysts in the pediatric population are rare conditions that require careful evaluation. In this review of the literature we discuss the evaluation of clitoral abnormalities in the pediatric population, the development of clitoral cysts, and how to differentiate benign from malignant tumors. In addition, a summary of relevant cases of clitoral tumors in the literature are discussed. Read More

J Pediatr Adolesc Gynecol 2016 Oct 13;29(5):e79-e81. Epub 2016 May 13.

Chief of Pediatric Surgery, Department of Pediatric Surgery, Emergency Children's Hospital, Cluj-Napoca, Romania.

Background: Supernumerary breast or polymastia is a well documented anomaly of the breast, and commonly presents along the embryonic milk line extending between the axilla and groin. However, cases of polymastia have been recorded in the face, vulva, and perineum. The clinical significance of these anomalies include their susceptibility to inflammatory and malignant changes, and their association with other congenital anomalies of the urinary and cardiovascular systems. Read More

Urol Ann 2016 Apr-Jun;8(2):163-7

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Introduction: Previous publications have shown an increased incidence of various malignancies amongst renal transplant populations. The objective of this study was to analyze the rate and types of malignancies occurring in the St. Michael's Hospital renal transplant population and to determine whether our results were comparable to those previously published. Read More

Pathology 2016 Jun 23;48(4):291-302. Epub 2016 Apr 23.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Marie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Growing evidence has established two major types of vulvar intraepithelial neoplasia (VIN), which correspond to two distinct oncogenic pathways to vulvar squamous cell carcinoma (VSCC). While the incidence of VSCC has remained relatively stable over the last three decades, the incidence of VIN has increased. VIN of usual type (uVIN) is human papillomavirus (HPV)-driven, affects younger women and is a multicentric disease. Read More