371 results match your criteria Malignant Vulvar Lesions


Prevention of Human Papillomavirus Infection. Beyond Cervical Cancer: A Brief Review.

Acta Med Port 2020 Mar 2;33(3):198-201. Epub 2020 Mar 2.

Department of Gynaecology. Hospital and University Centre of Coimbra. Coimbra. Department of Gynaecology. Faculty of Medicine. University of Coimbra. Coimbra. Portugal.

Introduction: Human papillomavirus is responsible for almost all cases of cervical cancer, an important portion of anogenital and oropharyngeal invasive and preinvasive lesions, as well as genital warts (condyloma acuminatum) and recurrent respiratory papillomatosis. Currently, three prophylactic vaccines against high-risk Human papillomavirus are commercialized in many countries worldwide.

Methods: To this non-systematic review the authors searched in MEDLINE/PubMed for systematic reviews, meta-analysis and randomized controlled trials, published in the last six years, using the terms "HPV", "non-cervical cancer" and "vaccine". Read More

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http://dx.doi.org/10.20344/amp.12259DOI Listing

Granular cell tumor a study of 42 cases and systemic review of the literature.

Pathol Res Pract 2020 Apr 12;216(4):152865. Epub 2020 Feb 12.

Department of Pathology, North Hospital, University Hospital of St-Etienne, France.

Background: Granular cell tumor (GCT) remains a diagnostic clinicopathologic problem because the exact frequency of its detailed morphological and clinical characteristics is unknown as most observations are collected from small series or isolated cases. Herein, our aim is to highlight the frequency of all clinicopathological characteristics of this rare tumor based in our series and the available medical (PubMed) literature.

Material And Methods: 42 cases were evaluated for: tissue layers involved by the tumor (in skin and mucosae), growth pattern, nuclear pleomorphism, mitotic index, necrosis, spindling, calcification, hyalinization, and pustule-ovoid bodies of Milian, as well as perineural and vascular invasion, and the presence of adjacent epithelium changes, and lymphocytes and eosinophils infiltration. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152865DOI Listing

Potential targets for tumor-specific imaging of vulvar squamous cell carcinoma: A systematic review of candidate biomarkers.

Gynecol Oncol 2020 Mar 9;156(3):734-743. Epub 2020 Jan 9.

Centre for Human Drug Research, Zernikedreef 8, 2333CL Leiden, the Netherlands; Department of Gynecology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands. Electronic address:

Introduction: Vulvar squamous cell carcinoma (VSCC) is a rare malignancy with an increasing incidence, especially in young women. Surgical treatment of VSCC is associated with significant morbidity and high recurrence rates, which is related to the limited ability to distinguish (pre)malignant from healthy tissue. There is a need for new tools for specific real-time detection of occult tumor lesions and localization of cancer margins in patients with VSCC. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.12.030DOI Listing

Incorporation of differentiated dysplasia improves prediction of oral leukoplakia at increased risk of malignant progression.

Mod Pathol 2020 Jan 2. Epub 2020 Jan 2.

Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Department of Oral and Maxillofacial Surgery/Oral Pathology, Cancer Center Amsterdam, de Boelelaan, 1117, Amsterdam, The Netherlands.

Oral leukoplakia is the most common oral potentially malignant disorder with a malignant transformation rate into oral squamous cell carcinoma of 1-3% annually. The presence and grade of World Health Organization defined dysplasia is an important histological marker to assess the risk for malignant transformation, but is not sufficiently accurate to personalize treatment and surveillance. Differentiated dysplasia, known from differentiated vulvar intraepithelial neoplasia, is hitherto not used in oral dysplasia grading. Read More

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http://dx.doi.org/10.1038/s41379-019-0444-0DOI Listing
January 2020

[Progressive necrosis of lipid: A case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Dec;51(6):1182-1184

Department of Rheumatology and Immunology, Shanxi Bethune Hospital, Taiyuan 030032, China.

A 61-year-old woman was referred to our department with a 11-year-erythra. In the anterior tibia of both lower extremities, we could see large dark red infiltrating erythema, waxy luster, clear boundary, slight central atrophy, depression and capillary dilatation. He was diagnosed with "dermatitis contusiformis" in local hospitals, but the treatment of traditional Chinese medicine and external drugs was not effective. Read More

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December 2019

Primitive neuroectodermal tumors of the abdominal wall and vulva in children: Report of two cases and review of the literature.

World J Clin Cases 2019 Nov;7(21):3671-3682

Department of Pediatric Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.

Background: Primitive neuroectodermal tumors are rare, highly malignant small round cell tumors belonging to the Ewing sarcoma family. The purpose of this article is to present clinical manifestation, histology, treatment, and prognosis of two primitive neuroectodermal tumors (PNETs) in extremely rare anatomic locations, the abdominal wall and vulva.

Case Summary: Case 1 was a 66-month-old girl with lesions on the abdominal wall; tumor size was about 3. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i21.3671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854414PMC
November 2019

Oral and Vulvar Lichen Sclerosus.

Acta Dermatovenerol Croat 2019 Sep;27(3):195-197

Ivana Škrinjar, MD, Department of Oral Medicine, University Hospital Center Zagreb, Gundulićeva 5, 10000 Zagreb, Croatia;

Lichen sclerosus (LS) is a chronic, inflammatory, mucocutaneous disorder of genital and extragenital skin (1). Simultaneous involvement of the oral mucosa is extremely rare, but it may be the only affected area (2). A 55-year-old woman was referred to the Department of Oral Medicine, School of Dental Medicine University of Zagreb due to whitish lesions on the right ventrolateral part of the tongue and buccal mucosa with desquamative gingivitis (Figure 1, a-c). Read More

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September 2019
3 Reads

Tumors of the reproductive tract of sheep and goats: A review of the current literature and a report of vaginal fibroma in an Awassi ewe.

Vet World 2019 Jun 11;12(6):778-782. Epub 2019 Jun 11.

Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Aims: This study aimed to provide a summary of all online available literature of published clinical and histopathological data regarding tumors affecting the reproductive tract of female sheep and goats. In addition, a detailed description of the clinical history, clinical findings, and gross and histopathological findings of one case of vaginal fibroma in an adult Awassi sheep is provided for the first time.

Materials And Methods: Internet search engines such as PubMed, ResearchGate, Scopus, ScienceDirect, and Google Scholar were used to collect all published articles in refereed journals from 2000 to 2018 regarding tumors and tumor-like lesions involving the reproductive tract of ewes and does. Read More

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http://dx.doi.org/10.14202/vetworld.2019.778-782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661476PMC
June 2019
6 Reads

Vulvovaginal Manifestations in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Prevention and Treatment.

J Am Acad Dermatol 2019 Aug 19. Epub 2019 Aug 19.

Department of Dermatology, MedStar Washington Hospital Center, Washington, DC. Electronic address:

The prevalence of acute vulvovaginal involvement in toxic epidermal necrolysis may be as high as 70%; up to 28% of females will also develop chronic vulvovaginal sequelae. There is little consensus regarding prevention and treatment of the gynecological sequelae of both Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). We review acute and chronic sequelae including erosions, scar formation, chronic skin changes, urethral complications, adenosis and malignant transformation, vulvodynia and dyspareunia. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.08.031DOI Listing
August 2019
4 Reads

No. 385-Indications for Pelvic Examination.

J Obstet Gynaecol Can 2019 Aug;41(8):1221-1234

Winnipeg, MB (GOC).

Objective: The primary objective of this document is to clarify the indications for pelvic examination.

Intended Users: Physicians, including gynaecologists, obstetricians, family physicians, and emergency physicians; nurses, including registered nurses and nurse practitioners; midwives, including midwives in clinical practice and midwifery trainees; medical trainees, including medical students, residents, and fellows; and all other health care providers who care for women.

Target Population: This publication provides evidence and expert-based recommendations for pelvic examination in adult women (18 years and older) both with and without gynaecologic symptoms. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.12.007DOI Listing
August 2019
7 Reads

[Verneuil's disease: a diagnosis that should be taken into consideration in patients with vulvar and perineal tumor-like lesion].

Pan Afr Med J 2018 3;31:76. Epub 2018 Oct 3.

Service de Gynécologie Obstétrique, Centre Hospitalo-Universitaire Fattouma Bourguiba de Monastir, Rue du 1 Juin 1955, Monastir 5000, Tunisie.

We here report the case of a 58-year old nulliparous patient with a history of Niemann-Pick disease who presented with vulvoperineal, fluctuant, fistulized swelling measuring 10 cm associated with ulceration. The patient was febrile with impaired general state This mass caused some concern about necrotic and infected malignant tumor of the vulva associated with chronic dermatosis. Incision and purulent drainage associated with multiple biopsies excluded the presence of a neoplastic process. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.76.17107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457728PMC
April 2019
10 Reads

Giant Fibroepithelial Polyp of Vulva: A Case Report and Review of Literature.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):127-130

Department of Gynecology and Obstetrics, Clinical Hospital, Tetovo, Republic of Macedonia.

Fibroepithelial stromal polyps of vulva are the type of mesenchymal lesion that typically occurs in women of reproductive period. They are common, usually small and hystologically benign. Larger lesions are rare and likely arise from proliferation of mesenchymal cells within the hormonally sensitive subepithelial stromal layer of the lower genital tract. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0051DOI Listing
December 2018
17 Reads

Adaptation of Alpha-Papillomavirus over Millennia.

Acta Cytol 2019 13;63(2):97-99. Epub 2018 Dec 13.

Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil,

Papillomaviruses (PVs) are a group of small DNA viruses that, with around 350 million years of evolution, acquired the capacity of infecting a broad range of vertebrates, including humans. To date, more than 300 PV types have been isolated. Viruses that have a long common evolutionary history with their host typically cause unapparent infections. Read More

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https://www.karger.com/Article/FullText/492658
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http://dx.doi.org/10.1159/000492658DOI Listing
May 2019
33 Reads

Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands.

Int J Urol 2019 03 3;26(3):353-357. Epub 2018 Dec 3.

Department of Urology, University Medical Center Utrecht, Utrecht, the Netherlands.

Objective: To determine the incidence of penile intraepithelial neoplasia in the Netherlands using a nationwide histopathology registry and to discuss the nomenclature of premalignant penile lesions.

Methods: Data from patients in the Netherlands diagnosed with a premalignant penile lesion between January 1998 and December 2007 were collected from the nationwide histopathology registry (PALGA); this database covers all pathology reports of inhabitants in the Netherlands. The premalignant lesions included were erythroplasia of Queyrat; Bowen's disease; bowenoid papulosis; mild, moderate and severe dysplasia; and carcinoma in situ of the penis. Read More

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http://dx.doi.org/10.1111/iju.13871DOI Listing
March 2019
40 Reads
1.798 Impact Factor

Successful treatment of high-grade vulval intra-epithelial neoplasia with imiquimod 5% in a renal transplant recipient.

Int J STD AIDS 2019 02 4;30(2):198-200. Epub 2018 Oct 4.

3 Department of GU Medicine, Solent NHS Trust, Southampton, UK.

Organ transplant recipients are at a higher risk of pre-malignant human papillomavirus-associated lesions due to immunosuppression. The efficacy of immunomodulants such as imiquimod 5% is not yet fully evaluated in this population. We describe a case of vulval intra-epithelial neoplasia in a renal transplant recipient which was successfully treated with topical imiquimod. Read More

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http://dx.doi.org/10.1177/0956462418797244DOI Listing
February 2019
3 Reads

Quality of Life and Sexual Functioning After Vulvar Reconstruction With the Lotus Petal Flap.

Int J Gynecol Cancer 2018 11;28(9):1728-1736

Department of Plastic Surgery.

Objective: Resection of (pre) malignant lesions in the vulvoperineal area may result in large defects that cannot be closed primarily. The lotus petal flap technique is widely used for reconstruction. The aim of this study was to evaluate both quality of life (QoL) and sexual functioning of patients who underwent the lotus petal flap procedure, because no data are available on this topic. Read More

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http://dx.doi.org/10.1097/IGC.0000000000001340DOI Listing
November 2018
48 Reads

Low-grade endometrial stromal sarcoma presenting as multiple pulmonary nodules: A potential pitfall in fine needle aspiration and core biopsy specimens - A Cytological - Pathological Correlation.

Ann Diagn Pathol 2018 Oct 30;36:38-43. Epub 2018 Jun 30.

Weill Cornell Medical College, Department of Pathology and Laboratory Medicine, 1300 York Ave, New York, NY 10065, United States of America. Electronic address:

Low-grade endometrial stromal sarcoma (LGESS) is the second most common malignant mesenchymal tumor of the uterus. The most common location is the uterine corpus, but it can also primarily arise in a variety of extrauterine locations such as pelvis, ovary, abdominal cavity, vagina, and vulva. We are reporting a case of a 47-year-old female with no significant medical history who presented with multiple pulmonary nodules. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.06.004DOI Listing
October 2018
17 Reads

Evaluation of large clinically atypical vulvar pigmentation with RCM: atypical melanosis or early melanoma?

J Eur Acad Dermatol Venereol 2019 Jan 12;33(1):84-92. Epub 2018 Jul 12.

Dermatology Department, Centre Hospitalier de Lyon Sud, Hospices civils de Lyon, Université Claude Bernard Lyon 1, Pierre Bénite, France.

Background: Vulvar melanosis can occasionally be clinically challenging by mimicking an early melanoma.

Objective: To report our experience of initial evaluation and follow-up in this peculiar subset of vulvar melanosis using reflectance confocal microscopy (RCM).

Methods: We retrospectively evaluated 18 consecutive cases referred for atypical vulvar pigmentation or for which melanoma was considered and that underwent both RCM examination and histopathological assessment. Read More

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http://dx.doi.org/10.1111/jdv.15141DOI Listing
January 2019
33 Reads

Repeated Use of Gluteal Fold Flaps for Post-Oncologic Vulvoperineal Reconstruction.

Ann Plast Surg 2018 Jun;80(6):648-652

Gynecologic Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

Background And Aim: Because of the associated high recurrence rate, future reconstructive options should be reckoned with during surgical treatment of primary or recurrent (pre)malignant vulvoperineal lesions. One of the claimed advantages of the gluteal fold flap is the possibility of repeated use of the flap in case of recurrence. We present our experience with such reuse of gluteal fold flaps to illustrate this possibility. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001445DOI Listing
June 2018
10 Reads

Para - And Intraurethral Penile Tumor - Like Condilomatosis.

Open Access Maced J Med Sci 2018 Jan 13;6(1):110-111. Epub 2018 Jan 13.

"Onkoderma"- Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.

Condyloma acuminata represents an epidermal manifestation, associated with the epidermotropic human papillomavirus (HPV). They have been reported as the most common sexually transmitted disease, with prevalence exceeding 50%, increased up to 4 times, within the last two decades, as the most common side of affection are the penis, vulva, vagina, cervix, perineum, and perianal area, with increased prevalence in young, sexually active individuals. Increased attention should be focused on lesions, caused by types, with moderate (33, 35, 39, 40, 43, 45, 51-56, 58) or high risk potential (types 16, 18) for malignant transformation, leading to further development of cancers of anus, vagina, vulva and penis, as well as cancers of the head and neck. Read More

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http://dx.doi.org/10.3889/oamjms.2018.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816275PMC
January 2018
15 Reads

Postpartum Genital Melanoma - A Case Report.

Rev Bras Ginecol Obstet 2018 Mar 23;40(3):163-167. Epub 2018 Feb 23.

Faculdade de Medicina, Universidade do Oeste Paulista, Presidente Prudente, São Paulo, Brazil.

Melanomas of the female genital tract may occur in the vulva, the vagina, the ovary or the cervix. Pregnancy has been considered an aggravating factor in the evolution and prognosis of melanoma. A 35-year-old female presented with vaginal bleeding 2 months after a term cesarean delivery. Read More

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http://dx.doi.org/10.1055/s-0038-1624578DOI Listing
March 2018
20 Reads

Pediatric Granular Cell Tumors of the Vulva: A Report of 4 Cases and a Review of the Literature.

J Pediatr Adolesc Gynecol 2018 Jun 3;31(3):311-314. Epub 2018 Jan 3.

Department of Gynecology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts.

Background: Granular cell tumors (GCTs) are rare soft tissue lesions that can involve the female genital tract, including the vulva. Although malignant tumors are aggressive and uncommon, benign and atypical lesions still have associated risks, including recurrence and multisite development.

Cases: Four cases of pediatric vulvar GCT are presented, including 1 atypical and 3 benign tumors. Read More

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http://dx.doi.org/10.1016/j.jpag.2017.12.010DOI Listing
June 2018
27 Reads

Robot-assisted anterior pelvic exenteration in vulvovaginal malignant melanoma.

Gynecol Oncol 2018 02 21;148(2):430-431. Epub 2017 Dec 21.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: Melanomas of the vulva and vagina are rare, and surgery is the gold standard of treatment [1, 2]. Since recent studies have reported pelvic exenteration by using robotic surgical system [3, 4], we showed the surgical procedures of robot-assisted anterior pelvic exenteration (rAPE) with ileal conduit urinary diversion for vulvovaginal malignant melanoma.

Methods: A 55-year-old woman who received vaginal wall resection due to vaginal malignant melanoma 8months before was referred. Read More

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http://dx.doi.org/10.1016/j.ygyno.2017.12.022DOI Listing
February 2018
25 Reads

Comparison of F-FDG PET/MRI and MRI alone for whole-body staging and potential impact on therapeutic management of women with suspected recurrent pelvic cancer: a follow-up study.

Eur J Nucl Med Mol Imaging 2018 04 21;45(4):622-629. Epub 2017 Nov 21.

Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, D-45147, Essen, Germany.

Purpose: To evaluate the diagnostic performance of F-FDG PET/MRI for whole-body staging and potential changes in therapeutic management of women with suspected recurrent pelvic cancer in comparison with MRI alone.

Methods: Seventy-one consecutive women (54 ± 13 years, range: 25-80 years) with suspected recurrence of cervical (32), ovarian (26), endometrial (7), vulvar (4), and vaginal (2) cancer underwent PET/MRI including a diagnostic contrast-enhanced MRI protocol. PET/MRI and MRI datasets were separately evaluated regarding lesion count, localization, categorization (benign/malignant), and diagnostic confidence (3-point scale; 1-3) by two physicians. Read More

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http://dx.doi.org/10.1007/s00259-017-3881-3DOI Listing
April 2018
41 Reads

Solitary fibrous tumour of the female genital tract: a clinicopathological analysis of 25 cases.

Histopathology 2018 Apr 26;72(5):749-759. Epub 2018 Jan 26.

Division of Women's & Perinatal Pathology, Department of Pathology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

Aims: Solitary fibrous tumour (SFT) is an uncommon spindle cell neoplasm of fibroblastic origin, first described as a tumour of the pleura and now well established at extrapleural sites. However, SFT in the female genital tract is rare and therefore not fully characterised. Here, we describe a series of 25 SFTs arising throughout the gynaecological tract, including the vulva (14 cases), vagina (one), cervix (one), uterus (six), ovary (two), and fallopian tube (one). Read More

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http://doi.wiley.com/10.1111/his.13430
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http://dx.doi.org/10.1111/his.13430DOI Listing
April 2018
14 Reads

Leptomeningeal metastasis of pulmonary large-cell neuroendocrine carcinoma: A case report and review of the literature.

Oncol Lett 2017 Oct 26;14(4):4282-4286. Epub 2017 Jul 26.

Department of Radiation-Oncology, Tumor Hospital of Jilin, Changchun, Jilin 130000, P.R. China.

Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare and malignant form of lung cancer with a poor prognosis for patients. The common sites of metastases are the liver, adrenal glands, bone and brain. LCNEC rarely metastasizes to the small intestine, ovaries, tonsils, mandible, vulva or spine. Read More

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http://dx.doi.org/10.3892/ol.2017.6676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605966PMC
October 2017
57 Reads

Therapeutic startegies for human papillomavirus infection and associated cancers.

Front Biosci (Elite Ed) 2018 Jan 1;10:15-73. Epub 2018 Jan 1.

Molecular Oncology Laboratory, Department of Zoology, University of Delhi, Delhi 110007, India.

Human papillomavirus (HPV) infection is linked to development of cancer of cervix, vagina, vulva, penis, ano-genital and non-genital oro-pharyngeal sites. HPV being a sexually transmitted virus infects both genders equally but with higher chances of pathological outcome in women. In the absence of organized screening programs, women report HPV-infected lesions at relatively advanced stages where they are subjected to standard treatments that are not HPV-specific. Read More

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http://dx.doi.org/10.2741/e808DOI Listing
January 2018
16 Reads

Nodular Hyperplasia of the Bartholin Gland, A Benign Mimicker of Aggressive Angiomyxoma: A Case Series and Literature Review.

Int J Gynecol Pathol 2018 Nov;37(6):554-558

Department of Pathology and Microbiology (Y.A.T.), University of Nebraska Medical Center, Omaha, Nebraska; Department of Pathology and Laboratory Medicine (Y.A.T., W.D.L., S.E.S.), The Warren Alpert Medical School of Brown University and Women & Infants Hospital, Providence, Rhode Island.

Nodular hyperplasia (NH) of the Bartholin gland is an exceedingly rare benign solid lesion of the female genital tract that can mimic the Bartholin gland cyst clinically. The histologic criteria for NH were established in 1998 by Koenig and Tavassoli. In this case series, we describe 4 cases of NH from Women and Infants Hospital in Rhode Island. Read More

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http://Insights.ovid.com/crossref?an=00004347-900000000-9925
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http://dx.doi.org/10.1097/PGP.0000000000000456DOI Listing
November 2018
27 Reads

Clinician's Update on the Benign, Premalignant, and Malignant Skin Tumours of the Vulva: The Dermatologist's View.

Int Sch Res Notices 2017 25;2017:2414569. Epub 2017 Jul 25.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

Correct and rapid diagnosis of skin tumours often requires biopsy and histopathological examination to differentiate benign lesions such as seborrhoeic keratoses or melanocytic naevi from premalignant and malignant lesions such as malignant melanoma. Particularly, to the untrained eye, any benign skin tumour-pigmented or nonpigmented-is easily mistaken for a malignant lesion. Qualified clinical evaluation is paramount in order to reduce the frequency of unwarranted skin biopsies. Read More

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http://dx.doi.org/10.1155/2017/2414569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547714PMC
July 2017
15 Reads

Vulvar Neoplasms, Benign and Malignant.

Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352

Bethesda Dermpath Laboratory, 1730 Elton Road, Suite 11, Silver Spring, MD 20903, USA; Anne Arundel Dermatology, Towson, MD 21204, USA; Pathology, Johns Hopkins University, 4940 Bayview Medical Center, Eastern Avenue, Baltimore, MD 21224, USA. Electronic address:

Cutaneous vulvar neoplasms are commonly encountered at gynecology visits, with 2% of women having a benign vulvar melanocytic nevus and 10% to 12% of nevi being vulvar. High-grade squamous intraepithelial lesions (vulvar intraepithelial neoplasia 2 or 3) occurs in 5 per 100,000 women, with increasing incidence in the past 30 years. The recognition of these lesions and differentiation between benign, premalignant, and malignant stages are crucial for adequate diagnosis, clinical monitoring, and treatment. Read More

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http://dx.doi.org/10.1016/j.ogc.2017.04.002DOI Listing
September 2017
48 Reads

Urologic Dermatology: a Review.

Curr Urol Rep 2017 Aug;18(8):62

Virginia Mason Medical Center, Seattle, WA, USA.

Purpose Of Review: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic. Read More

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http://dx.doi.org/10.1007/s11934-017-0712-9DOI Listing
August 2017
84 Reads

Role of Human Papillomavirus in Vulvar Cancer.

Adv Anat Pathol 2017 Jul;24(4):201-214

Departments of *Pathology †Obstetrics and Gynecology, Hospital Clínic ‡Faculty of Medicine, University of Barcelona §ISGlobal, Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain.

Human papillomavirus (HPV) is involved in one of the at least 2 pathways leading to vulvar squamous cell carcinoma (VSCC). Inactivation of p53 and retinoblastoma by the viral products E6 and E7 is involved in malignant transformation. The percentage of HPV-positive VSCCs ranges from 18% to 75%, depending on the geographical area. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000155DOI Listing
July 2017
98 Reads

Comparison of V-Y Advancement Flap Versus Lotus Petal Flap for Plastic Reconstruction After Surgery in Case of Vulvar Malignancies: A Retrospective Single Center Experience.

Ann Plast Surg 2017 Aug;79(2):186-191

From the *Division of Plastic Surgery, San Gerardo Hospital; and †Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, University of Milano-Bicocca, Monza, Italy.

Vulvoperineal defects after demolitive surgery for preneoplastic or malignant vulvar lesions require a reconstruction to restore good sexual functions and to offer a satisfactory cosmetic result. Several techniques of reconstruction have been described in the past, leading to a more conservative and localized treatment. This study retrospectively reviewed patients with primary or recurrent vulvar malignancies that had undergone vulvoperineal reconstruction between 2010 and 2016 using the V-Y advancement flap and the 2 variant of the lotus petal flap (LPF) in terms of surgical outcome and postoperative complications. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001094DOI Listing
August 2017
75 Reads

Bilateral Giant Fibroepithelial Labial Mass: A Case Report.

J Obstet Gynaecol Can 2017 Jul 6;39(7):564-566. Epub 2017 May 6.

Sir Sanusi Specialist Hospital, Kano, Nigeria.

Background: Fibro-epithelial polyps are benign soft tissue lesions that occur in a wide variety of sites, including the lower female genital tract. They exhibit a wide range of morphologic appearances and can be misinterpreted as malignant. These polyps therefore pose adiagnostic challenge to both the clinician and the pathologist. Read More

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http://dx.doi.org/10.1016/j.jogc.2017.02.008DOI Listing
July 2017
17 Reads

Vascular lesions of the female genital tract: Clinicopathologic findings and application of the ISSVA classification.

Pathophysiology 2017 Sep 23;24(3):161-167. Epub 2017 Apr 23.

Department of Pathology, North Hospital, University Hospital of St-Etienne, France.

Introduction: Vascular lesions of the female genital tract are extremely rare and their nomenclature does not widely follow the International Society for the Study of Vascular Anomalies (ISSVA) classification.

Aim Of The Study: To describe the clinicopathologic characteristics of vascular lesions of the female genital tract and to apply the ISSVA classification.

Material And Methods: 19 vascular lesions were diagnosed during a 20 year period. Read More

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http://dx.doi.org/10.1016/j.pathophys.2017.04.002DOI Listing
September 2017
46 Reads

Study of Selected BRCA1, BRCA2, and PIK3CA Mutations in Benign and Malignant Lesions of Anogenital Mammary-Like Glands.

Am J Dermatopathol 2017 May;39(5):358-362

*Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint-Petersburg, Russia; ‡Department of Pathology, Saint-Petersburg Medico-Social Institute, Saint Petersburg, Russia; Departments of §Pathology, and ¶Tumor Growth Biology, Petrov's Research Institute of Oncology, Saint Petersburg, Russia; ‖Department of Medical Genetics, Saint Petersburg Pediatric Medical University, Saint Petersburg, Russia; **Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; and ††Bioptical Laboratory, Pilsen, Czech Republic.

Anogenital mammary-like glands (AGMLGs) are nowadays considered a normal component of the anogenital area. Lesions involving AGMLGs are histopathologically very similar to their mammary counterparts, but the information on molecular biological mechanisms in these vulvar/perianal tumors is scarce. Mutations in the PI3K-AKT cascade have been found in hidradenoma papilliferum. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000725DOI Listing
May 2017
61 Reads

A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal Wall.

Case Rep Obstet Gynecol 2017 18;2017:5656340. Epub 2017 Jan 18.

Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama, Japan.

Malignant melanoma (MM) in the female genital tract accounts for less than 2% of all melanomas, and the vast majority associated occur in the vulva and vagina. Primary MM of the uterine cervix is extremely rare and its prognosis is very poor. We report a case of primary MM of the cervix with dissemination throughout the vaginal wall. Read More

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http://dx.doi.org/10.1155/2017/5656340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286487PMC
January 2017
51 Reads

Vulvar and gastric involvement in plasmablastic lymphoma.

Eur J Gynaecol Oncol 2017 ;38(2):308-310

Plasmablastic lymphoma is highly malignant and invasive. It is most commonly found in gastrointestinal tract and is strongly asso- ciated with human immunodeficiency virus (HIV). The authors report a case of a 37-year-old HIV-positive African American woman with a vulvar mass diagnosed as plasmablastic lymphoma. Read More

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July 2018
13 Reads

Detection of Human Papillomavirus Infection in Patients with Vaginal Intraepithelial Neoplasia.

PLoS One 2016 1;11(12):e0167386. Epub 2016 Dec 1.

Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany.

Introduction: Vaginal intraepithelial neoplasia (VAIN) is a pre-malignant lesion, potentially leading to vaginal cancer. It is a rare disease, representing less than 1% of all intraepithelial neoplasia of the female genital tract. Similar to cervical intraepithelial neoplasia (CIN), there are three different grades of VAIN. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167386PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132291PMC
July 2017
29 Reads

[Current knowledge about HPV infection].

Ceska Gynekol Fall 2016;81(5):369-375

Objective: Overview of current data on HPV infection.

Design: Review article.

Setting: Clinic of Gynecology and Obstetrics, University Hospital in Ostrava, Clinic of Obstetrics and Gynecology, University Hospital in Hradec Králové, Clinic of Gynecology and Obstetrics, General University Hospital in Prague. Read More

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June 2017
18 Reads

[Vulvar squamous precancerous lesions History and current state of the topic].

Ceska Gynekol Summer 2016;81(3):172-176

This review article discribes the genesis and development of vulvar squamous precancerous lesions terminology and discusses the consensus of the International Society for the Study of Vulvovaginal Disease, the American Society for Colposcopy and Cervical Pathology, College of American Pathologists and the World Health Organization on the current terminology. The article describes the different types of vulvar squamous precancerous lesions, according to their etiology, incidence and malignant potential. Read More

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October 2018
16 Reads

Giant Condyloma (Buschke-Loewenstein Tumor) in a 16-year-old Patient: Case Report.

Rev Bras Ginecol Obstet 2016 Sep 27;38(9):471-476. Epub 2016 Oct 27.

Gynecology and Obstetrics Department, Ribeirão Preto Faculty of Medicine, USP, Ribeirão Preto, SP, Brazil.

The Buschke-Loewenstein tumor is characterized by excessive growth of verrucous lesions on the genitals and/or perianal region. It is considered benign despite the high rate of recurrence and the possibility of malignant transformation. It is commonly associated with subtypes 6 and 11 of the human papillomavirus (HPV), and host's immunity plays an important role in the development of the disease. Read More

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http://dx.doi.org/10.1055/s-0036-1593776DOI Listing
September 2016
37 Reads

Vulvar granular cell tumor.

Indian J Pathol Microbiol 2016 Jul-Sep;59(3):389-91

Department of Pathology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Granular cell tumors (GCTs) are rare and approximately half of the all lesions arise from head and neck, especially from the tongue. However, they are rarely seen in the vulva. They can occur in patients of any age, but peak age incidence is in the fourth to sixth decades. Read More

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http://dx.doi.org/10.4103/0377-4929.188134DOI Listing
March 2017
59 Reads

Presentation of a patient with in situ amelanotic melanoma of the vulva.

Eur J Gynaecol Oncol 2016 08;37(4):578-580

Amelanotic malignant melanoma of the vulva is extremely rare. The authors describe here a case of amelanotic malignant melanoma of the vulva, occurring in a 71-year-old woman without any clinical symptoms. The woman had a small nodular lesion in the left labia majora. Read More

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August 2016
9 Reads

Vulvar and Vaginal Cancer, Vulvar Intraepithelial Neoplasia 3 and Vaginal Intraepithelial Neoplasia 3: Experience of a Referral Institute.

Isr Med Assoc J 2016 May;18(5):286-9

Background: Vulvar and vaginal malignant and premalignant lesions are uncommon and are clinically heterogeneous diseases with two pathways of carcinogenesis: human papillomavirus (HPV) induced or non-HPV induced.

Objectives: To evaluate the demographic and clinical characteristics associated with vulvar or vaginal cancer and vulvar and vaginal intraepithelial neoplasia 3 (VIN3, VAIN3).

Methods: We conducted a retrospective chart review of 148 women with vulvar and vaginal malignancy and pre-malignancy for the period October 2004 to October 2012, and identified 59 and 19 patients with vulvar and vaginal cancer respectively, and 57 and 13 patients with VIN3 and VAIN3 respectively

Results: The median age of vulvar cancer patients was 30 years older than that of VIN3 patients. Read More

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May 2016
16 Reads

MALDI Mass Spectrometry Imaging Reveals Decreased CK5 Levels in Vulvar Squamous Cell Carcinomas Compared to the Precursor Lesion Differentiated Vulvar Intraepithelial Neoplasia.

Int J Mol Sci 2016 Jul 8;17(7). Epub 2016 Jul 8.

Adelaide Proteomics Centre, School of Biological Sciences, The University of Adelaide, Adelaide 5005, Australia.

Vulvar cancer is the fourth most common gynecological cancer worldwide. However, limited studies have been completed on the molecular characterization of vulvar squamous cell carcinoma resulting in a poor understanding of the disease initiation and progression. Analysis and early detection of the precursor lesion of HPV-independent vulvar squamous cell carcinoma (VSCC), differentiated vulvar intraepithelial neoplasia (dVIN), is of great importance given dVIN lesions have a high level of malignant potential. Read More

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http://dx.doi.org/10.3390/ijms17071088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964464PMC
July 2016
30 Reads

Literature Review of Periclitoral Cysts in the Prepubertal Population.

J Pediatr Adolesc Gynecol 2016 Dec 27;29(6):558-561. Epub 2016 May 27.

Obstetrics and Gynecology, Pediatric Gynecology, University of Calgary, The Alberta Children's Hospital, Calgary, Alberta, Canada.

Study Objective: Clitoral cysts in the pediatric population are rare conditions that require careful evaluation. In this review of the literature we discuss the evaluation of clitoral abnormalities in the pediatric population, the development of clitoral cysts, and how to differentiate benign from malignant tumors. In addition, a summary of relevant cases of clitoral tumors in the literature are discussed. Read More

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http://dx.doi.org/10.1016/j.jpag.2016.05.005DOI Listing
December 2016
39 Reads

Fibroadenoma in Axillary Supernumerary Breast in a 17-Year-Old Girl: Case Report.

J Pediatr Adolesc Gynecol 2016 Oct 13;29(5):e79-e81. Epub 2016 May 13.

Chief of Pediatric Surgery, Department of Pediatric Surgery, Emergency Children's Hospital, Cluj-Napoca, Romania.

Background: Supernumerary breast or polymastia is a well documented anomaly of the breast, and commonly presents along the embryonic milk line extending between the axilla and groin. However, cases of polymastia have been recorded in the face, vulva, and perineum. The clinical significance of these anomalies include their susceptibility to inflammatory and malignant changes, and their association with other congenital anomalies of the urinary and cardiovascular systems. Read More

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http://dx.doi.org/10.1016/j.jpag.2016.04.008DOI Listing
October 2016
53 Reads

Malignancies in a renal transplant population: The St. Michael's Hospital experience.

Urol Ann 2016 Apr-Jun;8(2):163-7

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Introduction: Previous publications have shown an increased incidence of various malignancies amongst renal transplant populations. The objective of this study was to analyze the rate and types of malignancies occurring in the St. Michael's Hospital renal transplant population and to determine whether our results were comparable to those previously published. Read More

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http://dx.doi.org/10.4103/0974-7796.165712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839232PMC
May 2016
43 Reads

Squamous precursor lesions of the vulva: current classification and diagnostic challenges.

Pathology 2016 Jun 23;48(4):291-302. Epub 2016 Apr 23.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Marie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Growing evidence has established two major types of vulvar intraepithelial neoplasia (VIN), which correspond to two distinct oncogenic pathways to vulvar squamous cell carcinoma (VSCC). While the incidence of VSCC has remained relatively stable over the last three decades, the incidence of VIN has increased. VIN of usual type (uVIN) is human papillomavirus (HPV)-driven, affects younger women and is a multicentric disease. Read More

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http://dx.doi.org/10.1016/j.pathol.2016.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518939PMC
June 2016
41 Reads