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Diagn Pathol 2022 May 30;17(1):48. Epub 2022 May 30.

Department of Pathological Anatomy, FMPM-UCA-CHU Mohamed VI, 40000, Marrakech, Morocco.

Introduction: Malignant schwannoma is a malignant tumor of differentiation of Schwann cells or perineural cells.

Observation: The patient was a 74-year-old woman with no particular pathological history. She presented swallowing difficulty of solids and odynophagia, evolving for 1 year. Read More

Medicine (Baltimore) 2022 May 20;101(20):e29246. Epub 2022 May 20.

Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea.

Rationale: Lymphoepithelial cyst of the oral cavity is very rare. Most intraoral lymphoepithelial cysts are observed in the floor of the mouth and very few cases have been reported of its occurrence in the palatine tonsil.

Patient Concerns: A 37-year-old healthy woman with no remarkable medical history visited our department with a complaint of frequent tonsillitis. Read More

Cureus 2022 Apr 4;14(4):e23815. Epub 2022 Apr 4.

Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, USA.

Thermoplastic masks are commonly used in radiation therapy to immobilize a patient's head and neck during treatment. They are primarily composed of non-toxic polyester compounds that can be manipulated with heat to mold the shape of a patient's head and neck. There is little previously reported evidence of these masks causing allergic contact dermatitis. Read More

J Vet Diagn Invest 2022 May 10;34(3):564-567. Epub 2022 Apr 10.

Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.

Given its unusual lymphatic drainage system, the tonsil is a rare site of metastasis, with few reports in the human and veterinary literature. Prognosis in cases of tonsillar metastasis is reportedly poor. We describe here a unique case of urinary bladder urothelial carcinoma (UC) with metastasis to the tonsil in an 11-y-old, spayed female, mixed-breed dog. Read More

J Otolaryngol Head Neck Surg 2022 Apr 6;51(1):14. Epub 2022 Apr 6.

Division of Otolaryngology - Head and Neck Surgery, Nova Scotia Health Authority, 5820 University Ave, Halifax, NS, Canada.

Background: Tonsillectomy is a commonly performed procedure in Canada. The rate of occult malignancy is rare in adult and pediatric populations. At present, no guidelines exist surrounding the need for routine histopathological evaluation of tonsil specimens when no malignancy is suspected. Read More

Acta Otolaryngol 2022 Mar-Apr;142(3-4):345-349. Epub 2022 Apr 5.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: Patients with locally advanced HPV-positive tonsil cancer would benefit from prophylactic contralateral neck dissection (pCND).

Aims/objectives: The aim of this study was to analyze rates of contralateral lymph node metastases (LNM) and their prognostic effects on locally advanced HPV-positive tonsillar squamous cell carcinoma.

Materials And Methods: Medical records of 54 patients who underwent upfront primary surgery and pCND were retrospectively reviewed. Read More

Asian Pac J Cancer Prev 2022 Mar 1;23(3):781-787. Epub 2022 Mar 1.

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are associated with head and neck cancer, including tonsil cancer (TC) in the oropharyngeal area. Increasing incidence of HPV and EBV infection in different cancer tissues of oropharynx in both epithelial and lymphoid tissues, have been reported. However, little is known about association of these tumor viruses with TC in the Thai population. Read More

DEN open 2022 Apr 1;2(1):e34. Epub 2021 Sep 1.

Department of Gastroenterohepatology Tokyo Teishin Hospital Tokyo Japan.

Rectal tonsils are localized hyperplastic lymphoid tissues in the rectum, and the initial endoscopic findings are consistent with those for neoplastic lesions. However, rectal tonsils are benign entities, and the diagnosis should be made cautiously. A 70-year-old man presented with pain on defecation with rectal bleeding. Read More

Oncologist 2022 02;27(1):48-56

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Objectives: The eighth edition American Joint Committee on Cancer (AJCC) Staging incorporates significant changes to the seventh edition in the staging of oropharyngeal squamous cell carcinomas (OPSCC). An important change was the inclusion of OPSCC associated with the human papilloma virus (HPV). Our goal is to compare the performance of both staging systems for patients with HPV-selected and unselected clinical characteristics for OPSCC. Read More

Cancer Epidemiol 2022 Jun 15;78:102140. Epub 2022 Mar 15.

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong, China; Kirby Institute, The University of New South Wales, Sydney, NSW, Australia. Electronic address:

Background: Oropharynx is the anatomical site with the highest human papillomavirus (HPV) infection in head and neck. Many studies on HPV prevalence and p16 positivity in oropharyngeal cancer have been published in recent years. We aimed to update the global burden estimates of oropharyngeal cancer attributable to HPV with the latest data and estimate global burden of tonsillar cancer and base of tongue cancer attributable to HPV by region and country. Read More

Front Oncol 2022 1;12:816903. Epub 2022 Mar 1.

College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, China.

Follicular dendritic cell sarcoma (FDCS) is a rare malignant neoplasm that was classified by the World Health Organization (WHO) under histiocytic and dendritic cell neoplasms in the 2016 revision. Considering the rarity of this tumor, there is no standardized treatment. It is usually treated by complete surgical resection. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Feb;36(2):130-135

1Department of Otolaryngology Head and Neck Surgery，the Second Affiliated Hospital of Xi'an Jiaotong University，Xi'an，710004，China.

The aim of this study is to analyze the application value of NBI endoscopy in finding the concealed primary lesions of misdiagnosis of oropharyngeal cancer. The clinical data of patients with missed oropharyngeal cancer treated in the Department of Otolaryngology Head and neck surgery, the Second Affiliated Hospital of Xi'an Jiaotong University from May 2018 to June 2021, were retrospectively studied, and the missed diagnosis was also analyzed combined with results of NBI endoscopy. In 31 cases of misdiagnosis of oropharyngeal cancer patients, including 25 males and 6 females, there was no significant difference in age, BMI index, course of disease and TNM stage （> 0. Read More

J Pak Med Assoc 2021 Jan;71(1(B)):352-355

Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.

The case of a 69-year-old man with bilateral synchronous tonsillar carcinoma is reported. The patient complained of nasal closure, strange voice, and discomfort in his pharynx when he was admitted to the Department of Otolaryngology Head and Neck Surgery at Wakayama Medical University, Wakayama, Japan, in March 2017. The palatine tonsils were enlarged and the surface was irregular. Read More

Iran J Otorhinolaryngol 2022 Jan;34(120):35-44

Health Human Resources Research Centre, School of Health Management and Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: The present study aimed to investigate the necessity or unnecessity of sending all tonsillectomy specimens for pathological examinations in Shiraz, Iran; moreover, it examined malignancies, cost-saving, causes, and the ways to prevent sending all specimens.

Materials And Methods: In the first retrospective phase of the study, a checklist was used to gather demographic, clinical, and cost information of 18,437 tonsillectomy specimens during 2004-2018 in Shiraz, Iran. In order to estimate the cost of each pathology specimen, the cost components, including human resources costs and consumables, were collected in the private and public sectors separately and divided by the number of cases performed. Read More

Head Neck 2022 04 9;44(4):989-997. Epub 2022 Feb 9.

Department of Radiation Oncology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.

Background: To evaluate the efficacy and safety of reducing target volume in definitive radiotherapy for HPV-associated tonsil cancer.

Methods: A single-institution cohort of 90 patients with human papillomavirus (HPV)-associated tonsil cancer who received definitive radiotherapy with a 5-mm expansion from the gross tumor volume to clinical target volume between 2008 and 2019 were included. The overlapping volume of initial planning target volume and the recurrent tumor was calculated and categorized as one of three failure types: in-field: ≥95%; marginal-field: 50%-94%; and out-field: <50%. Read More

Radiother Oncol 2022 04 1;169:1-7. Epub 2022 Feb 1.

Department of Radiation Oncology, University Hospital Zürich, Switzerland. Electronic address:

Purpose/objective: Whereas the prevalence of lymph node level (LNL) involvement in head & neck squamous cell carcinomas (HNSCC) has been reported, the details of lymphatic progression patterns are insufficiently quantified. In this study, we investigate how the risk of metastases in each LNL depends on the involvement of upstream LNLs, T-category, HPV status and other risk factors.

Materials/methods: We retrospectively analyzed patients with newly diagnosed oropharyngeal squamous cell carcinoma (OPSCC) treated at a single institution, resulting in a dataset of 287 patients. Read More

J Med Chem 2022 02 26;65(3):2409-2433. Epub 2022 Jan 26.

Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.

We recently reported -substituted 3-methylcytidine-5'-α,β-methylenediphosphates as CD73 inhibitors, potentially useful in cancer immunotherapy. We now expand the structure-activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 ; = 0. Read More

Acta Oncol 2022 Feb 21;61(2):146-152. Epub 2022 Jan 21.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: To analyze the influence of radiation dose on late radiation-associated taste impairment in oropharyngeal cancer (OPC) patients treated with intensity-modulated radiotherapy (IMRT) using the taste bud bearing tongue mucosa as organ at risk.

Material And Methods: This study is part of an ongoing, prospective observational study. Cancer-free OPC survivors with at least 24 months from IMRT were included in this analysis. Read More

Rev Esp Enferm Dig 2022 05;114(5):299-300

Aparato Digestivo, Complejo Asistencial Universitario de León, España.

We present the case of a 77-year-old male patient with iron deficiency anemia. His personal medical history is: dyslipidemia, high-grade diffuse centrofollicular lymphoma localized in the tonsil in 1984 and metastatic prostate cancer treated with hormone therapy. Read More

Eur Arch Otorhinolaryngol 2022 Jul 14;279(7):3665-3669. Epub 2022 Jan 14.

Head and Neck Surgery, University Hospital of Leicester, Leicester, UK.

Objective: The literature is divided with regards to contralateral tonsillectomy in a known/suspected case of ipsilateral tonsillar malignancy. In this study, we evaluate the incidence of indolent synchronous contralateral tonsillar malignancy (SCTC) in patients with known ipsilateral tonsillar malignancy.

Methods: All patients diagnosed with ipsilateral tonsillar carcinoma (TC) at a tertiary teaching center between January 2016 and December 2019 were screened. Read More

Ear Nose Throat J 2022 Jan 10:1455613211072587. Epub 2022 Jan 10.

Department of Otorhinolaryngology-Head and Neck Surgery, 12390Zhongnan Hospital of Wuhan University, Wuhan, China.

Lipomas of the palatine tonsil are rare benign neoplasms in clinical practice. We present a case of palatine tonsillar fibroangiolipoma in a 50-year-old Chinese male with a history of multiple lipomas on the back and extremities. It was diagnosed based on histological examination and integrated analysis. Read More

Blood 2022 01;139(1):148

The University of Texas MD Anderson Cancer Center.

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jan;36(1):1-7

Department of Otolaryngology Head and Neck Surgery，the Second Affiliated Hospital of Xi'an Jiaotong University，Xi'an，710004，China.

To investigate the clinical features of diffuse large B-cell lymphoma （DLBCL） of head and neck. A retrospective study was conducted among patients with DLBCL in the Department of otolaryngology and head and neck surgery of the Second Affiliated Hospital of Xi'an Jiaotong University from July 2011 to September 2021. The disease location, clinical manifestations, diagnosis, treatment and prognosis of DLBCL patients in head and neck were analyzed retrospectively. Read More

Laryngoscope Investig Otolaryngol 2021 Dec 2;6(6):1395-1405. Epub 2021 Oct 2.

Department of Otorhinolaryngology, Head and Neck Surgery Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden.

Objective: To investigate if severe dysphagia following radiotherapy for head and neck cancer (HNC) could be predicted by patient and tumor characteristics, feeding tube use, weight factors, jaw opening function, and saliva secretion.

Methods: Data was collected from 94 HNC patients 6 to 36 months post radiotherapy. Swallowing function was assessed by videofluroscopy (VFS). Read More

Head Neck 2022 02 3;44(2):359-371. Epub 2021 Dec 3.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.

Background: Intensity-modulated proton therapy (IMPT) demonstrates superior dose distribution over volumetric-modulated arc therapy (VMAT) for sparing organs-at-risk (OARs) in ipsilateral radiotherapy. To determine a clinical benefit, assessment of patient-reported outcomes (PRO) and physician-reported toxicities alongside a dosimetric analysis is needed.

Methods: Plans were analyzed for dosimetric differences. Read More

Eur J Haematol 2022 Mar 15;108(3):223-231. Epub 2021 Dec 15.

Institute of Pathology, University Hospital Ulm, Ulm, Germany.

Introduction: Accumulating studies show that the tumour suppressor SOCS1 is one of the most frequently mutated genes in lymphomas, often affecting the coding sequence of SOCS1 protein. Depending on the type of mutation and lymphoma concerned, SOCS1 mutations have different impacts on progression-free and overall survival. Two antibodies binding the N and C terminals of SOCS1 would be a suitable 'test pair' to identify truncated versions of SOCS1. Read More

Eur J Med Genet 2022 Jan 15;65(1):104399. Epub 2021 Nov 15.

Genome Instability and DNA Repair Syndromes Group, Sant Pau Biomedical Research Institute (IIB Sant Pau), Join Unit UAB-IR Sant Pau on Genomic Medicine, 08041, Barcelona, Spain; Genetics Department, Hospital de la Santa Creu I Sant Pau, 08041, Barcelona, Spain; Genetics and Microbiology Department, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER), Sant Pau Biomedical Research Institute (IIB Sant Pau), 08041, Barcelona, Spain.

Fanconi anemia is primarily inherited as an autosomal recessive genetic disorder with common delays in diagnosis and challenging treatments. Fanconi anemia patients have a high risk of developing solid tumors, particularly in the head and neck or anogenital regions. The diagnosis of Fanconi anemia is primarily based on the chromosomal breakage but FA gene sequencing is recommended in all patients with a positive chromosome fragility test. Read More

BMJ Case Rep 2021 Nov 11;14(11). Epub 2021 Nov 11.

Otolaryngology - Head and Neck Surgery, Weill Cornell Medical College, New York, New York, USA.

Infection with Epstein-Barr virus (EBV) has been linked to approximately 10%-15% of lymphomas diagnosed in the USA, including a small percentage of Natural Killer (NK)/T cell lymphomas, which are clinically aggressive, respond poorly to chemotherapy and have a shorter survival. Here, we present a case of a patient found to have EBV-induced NK/T cell lymphoma from a chronic EBV infection. While the EBV most commonly infects B cells, it can infect NK/T cells, and it is important for the clinician to be aware of the potential transformation to lymphoma as it is clinically aggressive, warranting early recognition and treatment. Read More

Pan Afr Med J 2021 27;39:276. Epub 2021 Aug 27.

Department of Otorhinolaryngology Head and Neck Surgery, Gennimatas General Hospital, Thessaloniki, Greece.

Fibroepithelial polyps represent a frequent cutaneous lesion of mesodermal origin, with a prevalence of 1.2% and are rarely located at palatine tonsils. We present a rare clinical report of a 70-year-old female patient with fibroepithelial polyp of palatine tonsil. Read More

Clin Nucl Med 2021 Dec;46(12):999-1001

Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, UOC di Otorinolaringoiatria.

Abstract: A 75-year-old woman had an occasional finding of a left tonsil mass for dysphagia, which resulted a high-grade squamous carcinoma. Therefore, the patient was sent to have a left pharyngectomy. After the pharyngectomy, the patient reported persistent swallowing disorders and nasal reflux. Read More