Search Our Scientific Publications & Authors

Cancer Causes Control 2019 May 21;30(5):465-475. Epub 2019 Mar 21.

Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Purpose: Lung cancer is common and lethal, and can occur in survivors of previous cancers. We sought to describe the incidence and mortality attributable to second primary lung cancers (SPLC) among survivors of other cancers, and to identify survivors at highest risk.

Methods: We identified adults diagnosed with a localized malignancy from non-pulmonary cancer sites from surveillance, epidemiology, and end results (SEER) data from 1992 to 2008. Read More

Medicine (Baltimore) 2019 Mar;98(11):e14836

Department of Ophthalmology, The Second Xiangya Hospital.

Rationale: Extranodal natural killer T-cell lymphoma nasal type (ENKL) is an extremely rare tumor with a very low survival rate. In recent decades, only a few ENKL cases have been published. Presenting a special ENKL case lead the authors to emphasize the primary features of ENKL in early diagnosis and therapy. Read More

BJGP Open 2018 Dec 17;2(4):bjgpopen18X101608. Epub 2018 Oct 17.

Consultant Surgeon and Head of Specialty School Surgery, Wales Post Graduate Medical and Dental Education Deanery School of Surgery, Cardiff University, Cardiff, UK.

Background: Risk profile assessment and corrective interventions using optimisation of health status and prehabilitation represent an important strategy in the management of patients with a suspected cancer diagnosis.

Aim: To determine the feasibility of pre-treatment optimisation and prehabilitation commenced at index primary care consultation, to improve patients' preparation for treatment by maximising the time available.

Design & Setting: Between January 2015 and May 2016, 195 patients presenting to 12 GP practices were deemed eligible to enter the study, of which 189 (96. Read More

Int J Pediatr Otorhinolaryngol 2019 Mar 28;118:160-164. Epub 2018 Dec 28.

University of Central Florida College of Medicine, Orlando, FL, USA; Division of Otolaryngology, Nemours Children's Hospital, Orlando, FL, USA. Electronic address:

Objective: To examine the survival of pediatric tonsillar cancer patients and review a rare case of pediatric tonsillar cancer.

Methods: Pediatric patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of tonsillar malignancy using the ICD O-3 tonsil primary site codes of: C09.0, C09. Read More

Medicine (Baltimore) 2019 Jan;98(1):e14009

Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu.

Rationale: Lymphangiomatous polyps of the palatine tonsils are benign tumors that are rare in both adults and children. Most patients suffering from this disease present with nonspecific symptoms similar to those of chronic tonsillitis.

Patient Concern: We report a case of a 21-year-old male miner who presented with a chronic history of a foreign body sensation in the oropharynx and an intermittently sore throat. Read More

Int J Pediatr Otorhinolaryngol 2019 Feb 1;117:171-174. Epub 2018 Dec 1.

Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel; Department of Otolaryngology - Head and Neck Surgery, Galilee Medical Center, Nahariya, Israel. Electronic address:

Objective: To evaluate the incidence of tonsil and adenoid malignancy in pediatric patients in Israel compared to the known literature and to revisit the common practice of routine histopathologic examination of tonsils and adenoids.

Methods: Analysis of the Israel National Cancer Registry data on pediatric tonsil and adenoid malignancies between the years 2005 and 2015, and a systematic literature review of all relevant articles that reported on malignancies amongst pediatric patients who underwent tonsillectomy with or without adenoidectomy.

Results: Only seven cases of tonsillar malignancies were documented out of 152,352 (0. Read More

BMC Cancer 2018 Dec 4;18(1):1209. Epub 2018 Dec 4.

Department of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Hodgkin's lymphoma (HL) is characterized by a high background of inflammatory cells which play an important role for the pathogenesis of the disease. T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory immune checkpoint receptor and a putative target for novel immunotherapies. To study patterns of TIGIT expression in the T cell background surrounding malignant cells including Hodgkin cells, Reed-Sternberg cells and histiocytic cells, a microenvironment (ME) tissue microarray (TMA) was constructed from tissue punches measuring 2 mm in diameter obtained from formalin-fixed tissue samples of Hodgkin's lymphoma lymph nodes (n = 40) and normal human tonsil (n = 2). Read More

Biopreserv Biobank 2018 Oct 31. Epub 2018 Oct 31.

1 Ohio Consortium , Cooperative Human Tissue Network (CHTN) Midwestern Division, Columbus, Ohio.

Background: The Cooperative Human Tissue Network, Midwestern Division, is a National Cancer Institute-funded program that provides quality research biospecimens to qualified investigators. Consented human tissues are procured according to researcher specifications for weight (size) and preservation type; weights of samples in significant demand and limited supply are negotiated. Weights of procured tissues are entered into a dedicated biospecimen database. Read More

Turk Arch Otorhinolaryngol 2018 Sep 1;56(3):139-144. Epub 2018 Sep 1.

Department of Head and Neck Surgery and Otorhinolaryngology, A. C. Camargo Cancer Center, São Paulo, Brazil.

Objective: We aimed to evaluate the pattern of neck metastasis in patients with primary tonsillar carcinoma treated by primary surgery and neck dissection. Impact of the extent of neck dissection and level of metastatic nodes on survival were also evaluated.

Methods: We evaluated 163 consecutive patients with tonsillar squamous cell carcinoma submitted for neck dissection and staged as cN0-1. Read More

J Cancer Res Ther 2018 Sep;14(Supplement):S815-S817

Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala, India.

Malignant melanoma (MM) has a high potential of lymphatic and hematogeneous spread, and metastatic disease is always incurable with a high mortality. We present a rare phenomenon of MM metastasizing to the palatine tonsil. Read More

Med Phys 2018 Oct 19;45(10):4329-4344. Epub 2018 Sep 19.

Department of Medical Physics, Faculty of Medicine and Health, Örebro University, 70182, Örebro, Sweden.

Purpose: To evaluate two commercial CT metal artifact reduction (MAR) algorithms for use in proton treatment planning in the head and neck (H&N) area.

Methods: An anthropomorphic head phantom with removable metallic implants (dental fillings or neck implant) was CT-scanned to evaluate the O-MAR (Philips) and the iMAR (Siemens) algorithms. Reference images were acquired without any metallic implants in place. Read More

Ci Ji Yi Xue Za Zhi 2018 Jul-Sep;30(3):181-184

Department of Otolaryngology, Andaman and Nicobar Islands Institute of Medical Sciences, Port Blair, Andaman and Nicobar Islands, India.

Objective: Waldeyer's lymphatic ring consists of group of tonsils located over the posterior oropharyngeal wall. The palatine tonsils are largest tonsil. The present study was aimed to evaluate the significance of lymphoid hyperplasia, lymphocyte infiltration with and without defect in the surface epithelium in chronic tonsillitis (CT) and chronic adenotonsillar hypertrophy (CAH) in resected tonsillectomy and adenotonsillectomy specimens. Read More

J Clin Exp Hematop 2018 Sep 14;58(3):122-127. Epub 2018 Jul 14.

Recently, an in situ hybridization (ISH) and immunohistochemical study demonstrated that Epstein-Barr virus (EBV) infection may be involved in tonsillar hypertrophy and recurrent tonsillitis in children and young adolescents. The present study was based on 630 consecutive specimens from tonsillectomies performed at the Dokkyo University School of Medicine between 2002 and May 2017. Clinical findings were obtained from hospital records. Read More

Nat Commun 2018 07 2;9(1):2570. Epub 2018 Jul 2.

Institut Curie, PSL Research University, INSERM, U932, 26 rue d'Ulm, 75005, Paris, France.

Presentation of exogenous antigens on MHC-I molecules, termed cross-presentation, is essential for cytotoxic CD8 T cell responses. In mice, dendritic cells (DCs) that arise from monocytes (mo-DCs) during inflammation have a key function in these responses by cross-presenting antigens locally in peripheral tissues. Whether human naturally-occurring mo-DCs can cross-present is unknown. Read More

BMC Med Imaging 2018 06 18;18(1):19. Epub 2018 Jun 18.

Department of Pathology, Beykent University Medical Faculty, Istanbul, Turkey.

Background: Malignant plasma cell proliferation may present as a disseminated disease (multiple myeloma), a solitary plasmacytoma of bone, or an extramedullary plasmacytoma of soft tissue. The latter plasmacytomas represent approximately 3% of all plasma cell proliferations, and 80% develop in the head-and-neck region. The unexpected clinical presentation of such masses may be present. Read More

Pathology 2018 Aug 8;50(5):524-529. Epub 2018 Jun 8.

School of Medical Diagnostic and Translational Sciences, College of Health Sciences, Old Dominion University, Norfolk, VA, United States. Electronic address:

Interest into the cellular biology of human tonsillar crypts has grown in recent years because it is now known to be the site of origin of most human papilloma virus (HPV) induced oropharyngeal squamous cell carcinomas (OPSCC). Despite the interest, still relatively little is known regarding the cellular hierarchy and dynamics of this anatomical subsite. Here we evaluate normal tonsillar crypts for expression of putative stem cell markers. Read More

World J Surg Oncol 2018 Jun 5;16(1):104. Epub 2018 Jun 5.

Department of Surgical Oncology, Medias Klinikum GmbH & Co KG, Krankenhausstr. 3a, 84489, Burghausen, Germany.

Background: Chemoradiotherapy has a dominant role in therapy for head and neck cancers. However, impressive results are often disturbed by adverse events such as dysphagia, xerostomia, and functional speech and hearing loss. To avoid exceeding toxicity limits in patients with primary and recurrent cancers of the tonsils, chemotherapy was administered intra-arterially via implantable Jet-Port-Allround catheters. Read More

Int J Pediatr Otorhinolaryngol 2018 Jul 1;110:57-60. Epub 2018 May 1.

Otolaryngology Department, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool, L12 2AP, UK.

Introduction: Diagnostic tonsillectomy is performed to exclude malignancy. It is associated with a post-operative hemorrhage rate of 3.5%, (1) which is more dangerous in small children. Read More

Surgeon 2019 Feb 26;17(1):6-14. Epub 2018 May 26.

Department of Otolaryngology and Head and Neck Surgery, Nepean Hospital, Sydney, NSW, Australia; University of Sydney, Sydney, NSW, Australia. Electronic address:

Objective: The objective of our study was to assess whether HPV-positive TSCC had better survival and prognosis rates, when compared to HPV-negative TSCC.

Method: A systematic review and meta-analysis was performed comparing HPV status in TSCC patients. TSCC was confirmed with histopathology and HPV status was confirmed with PCR, immunohistochemistry and/or in-situ-hybridisation. Read More

J Pediatr 2018 06;197:3-4

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Aug;31(16):1298-1299

We describe a case of a 55-year-old man who presented with sore throat for two days, while neck swelling for one day, and was found to have a fistula in his left tonsil and an abscess in his left lateral pharyngeal wall with the lower bound to the upper border of the cricoid cartilage by ultrasonography and enhanced CT. The fistula from tonsillar fossa to hypopharynx was detected followed by left tonsillectomy, and then anterior wall of the fistula and mucosa covering it was resected. He was eventually diagnosed with incomplete second branchial fistula with infection, and was followed up for five years with no recurrence. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Nov;31(22):1705-1710

Department of Otorhinolaryngology Head and Neck Surgery, Peking University First Hospital, Beijing, 100034, China.

To evaluate the feasibility and effectiveness of coblation assisted transoral surgery for the treatment of oral and oropharyngeal malignancy. 19 patients who suffered from oral or oropharyngeal malignant tumors underwent coblation assisted transoral surgery from August 2008 to August 2017 were studied. According to the tumor sites and pathological results, there were four oral squamous cell carcinoma (SCC) (two tongue carcinoma and two mouth floor carcinoma), eleven oropharygneal SCC (five tonsillar carcinoma, four soft palate carcinoma, one tongue base cartinama and one multiple carcinoma invading both soft palatine and hypopharynx), and four lymphatic and hematopoietic malignancies (three tonsillar tumors and one tumor invading both tonsil and tongue base). Read More

Otolaryngol Pol 2018 Apr;72(2):30-35

Department of Otorhinolaryngology, Head and Neck Surgery, Leer, Germany.

Objective: The aim of this study was to compare QoL of oropharyngeal cancer survivors who had received different treatments.

Subjects And Methods: We contacted 954 survivors. Each survivor received the QoL questionnaires EORTC QLQ-C30 and EORTC QLQ-H&N35. Read More

Zhonghua Yi Xue Za Zhi 2018 Apr;98(16):1256-1260

Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.

To explore the value of Positron-Emission Tomography/Computed Tomography (PET/CT) in the prognosis of extranodal NK/T cell lymphoma. The patients of NK/T cell lymphoma diagnosed from January 2007 to July 2016 in Department of Pathology of Beijing Tongren Hospital were enrolled in this study. Seventy-two in-hospital patients were examined on the invasion of adjecent tissue or organ by PET/CT. Read More

Mult Scler Relat Disord 2018 Jul 2;23:24-26. Epub 2018 May 2.

Department of Otorhinolaryngology, Bussolengo Hospital, Verona, Italy. Electronic address:

Fingolimod is a commonly used treatment for highly active relapsing-remitting multiple sclerosis (MS). We describe the case of a 50-year old man on fingolimod since 2011 who presented, in April 2017, with a voluminous swelling of the left tonsil. A left tonsillectomy was performed, and histological exam disclosed a papillary squamous cell carcinoma of the palatine tonsil, with an in situ hybridization positive for human papillomavirus (HPV)-16 DNA. Read More

Aust Vet J 2018 May;96(5):184-187

QML Vetnostics, Murrarie, QLD, Australia.

Case Report: A 6-year-old speyed female Bull Arab-cross dog was found to have a small tonsillar nodule. Histological examination revealed a well-differentiated mast cell tumour (MCT). At initial staging, no evidence of concurrent cutaneous or visceral MCTs was found on a complete blood count, a single lateral thoracic radiograph, abdominal ultrasound or cytology of the spleen and regional lymph nodes. Read More

Am J Case Rep 2018 Apr 24;19:482-485. Epub 2018 Apr 24.

Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

BACKGROUND Extrapulmonary small cell carcinoma (SmCC) is a relatively rare clinical entity constituting only 2.5-5% of SmCCs. Recently, evidence has emerged that high-risk types of human papillomavirus (HPV) might play an etiologic role in oropharyngeal SmCC, similar to squamous cell carcinoma. Read More

J Formos Med Assoc 2019 Jan 7;118(1 Pt 1):203-208. Epub 2018 Apr 7.

Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Background: The incidence of HPV positive oropharyngeal cancer is increasing in Taiwan. Given this, it is critical to understand the prevalence of oral HPV infection since this cancer is potentially preventable. A community-based study was conducted to evaluate the prevalence of oral HPV infection and sexual behavior changes. Read More

J Pediatr 2018 06 28;197:309-309.e1. Epub 2018 Mar 28.

Department of Otolaryngology and Communication Enhancement Boston Children's Hospital; Department of Otolaryngology Harvard Medical School Boston, Massachusetts.

J Registry Manag 2017 ;44(2):54-61

BACKGROUND: For oropharyngeal (OP) cancers at anatomical sites regarded as related to human papillomavirus (HPV), surveillance using population-based cancer registries has shown that age-standardized incidence rates are higher in US non-Hispanic whites (NHWs) vs minority groups. Surveillance in large racially-ethnically diverse urban areas also should be considered. METHODS: Using the US Cancer Statistics database, age-standardized incidence rates per year were obtained for 2003–2013 for carcinomas of the tonsil, the OP site most strongly associated with HPV. Read More

J Registry Manag 2017 ;44(1):4-10

BACKGROUND: Age-standardized incidence rates (ASIRs) for US non-Hispanic whites (NHWs) have been increasing since 1999 for squamous cell carcinomas (SCC) at oropharyngeal (OP) anatomic sites strongly associated with human papillomavirus (HPV), as also reported from certain European countries. ASIRs declined slightly, however, from 2000–2006 to 2007–2012 in Stockholm County, Sweden (an urban area) for SCC of the tonsil (TSCC) but not base of tongue (BTSCC). For the United States, this study examined the growth of the epidemic of these cancers in 1992–2013. Read More

J Pediatr 2018 06 21;197:255-261.e1. Epub 2018 Mar 21.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, MA; Department of Otolaryngology, Harvard Medical School, Boston, MA.

Objective: To evaluate childhood and adolescent tonsil cancer incidence and to identify the clinical characteristics indicative of those patients who would benefit from urgent operative intervention.

Study Design: The Surveillance, Epidemiology and End Results 18 database, inclusive of national cancer statistics from 1973 to 2013, provided quantitative tonsil cancer incidence data. An institutional retrospective chart review of pediatric patients diagnosed with tonsil malignancy from January 2013 to January 2017 identified supplementary qualitative clinical presentation information. Read More

Zhonghua Bing Li Xue Za Zhi 2018 Mar;47(3):158-162

Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

To investigate clinicopathological features and prognosis of tonsillar mantle cell lymphoma(TMCL). Clinical data of 25 patients with TMCL at Beijing Friendship Hospital, Capital Medical University from 2002 to 2016 were included. All the cases were reviewed microscopically. Read More

Medicine (Baltimore) 2018 Jan;97(2):e9648

Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.

Rationale: The palatine tonsil is an important component of Waldeyer's ring and a site commonly involved by lymphoma. Interestingly, although it is a site of mucosa-associated lymphoid tissue (MALT), primary MALT lymphoma of the palatine tonsil is rare, especially with prominent plasmacytic differentiation.

Patient Concerns: A 59-year-old woman presented to the hospital with a 1-month history of odynophagia. Read More

Diagn Pathol 2018 Feb 20;13(1):14. Epub 2018 Feb 20.

Department of Pathology, Peking University First Hospital, 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Background: Mast cell leukemia (MCL) is a very rare form of systemic mastocytosis (SM) and accounts for less than 0.5% of all mastocytosis. The diagnosis of MCL requires the presence of SM criteria, accompanied by leukemic infiltrating of atypical mast cells (MCs) in bone marrow (BM), peripheral blood as well as extracutaneous organs. Read More

Am J Pathol 2018 05 17;188(5):1289-1299. Epub 2018 Feb 17.

Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

miRNAs are small noncoding RNAs involved in the posttranscriptional regulation of gene expression. Deregulated miRNA levels have been linked to Burkitt lymphoma (BL) pathogenesis. To date, the number of known pathogenesis-related miRNA-target gene interactions is limited. Read More

Indian J Otolaryngol Head Neck Surg 2018 Mar 21;70(1):159-161. Epub 2017 Jul 21.

Department of Pathology, Kovai Medical Center and Hospital, Coimbatore, Tamilnadu India.

Esthesioneuroblastomas are rare neuroectodermally derived neoplasms occurring in the upper nasal septum or cribriform plate. They have been rarely reported in other sites, when they are called ectopic esthesioneuroblastomas. Due to the scarcity of reports, publications and molecular/genetic studies of these tumours, their diagnosis is likely to be missed when they are ectopic. Read More

Int J Oral Maxillofac Surg 2018 Jul 13;47(7):846-853. Epub 2018 Feb 13.

Department of Otolaryngology-Head and Neck Surgery, Hallym University Medical Centre, Seoul, Republic of Korea. Electronic address:

The aim of this study was to determine whether base of tongue (BOT) cancer is tongue cancer located at the base of the tongue or lingual tonsil cancer originating from tonsil tissue. This was a retrospective study using data from The Cancer Genome Atlas (TCGA). The genomic patterns of three primary cancers (BOT, oral tongue, and tonsil) were compared to determine their similarities and differences. Read More

Medicine (Baltimore) 2018 Feb;97(7):e9761

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.

Rationale: Primary Hodgkin lymphoma (HL) involving the tonsil is extremely rare. Only about 20 such cases with verification of biopsy and immunohistochemistry have been reported. Because of its rarity and unremarkable clinical presentation, a timely correct diagnosis is very challenging. Read More

Rev Saude Publica 2018 Feb 5;52:10. Epub 2018 Feb 5.

Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Epidemiologia. São Paulo, SP, Brasil.

Objective: To analyze the trend of oral and pharyngeal cancer mortality rates in the period of 2002 to 2013 in Brazil according to sex, anatomical site, and macroregion of the country.

Methods: The mortality data were obtained from the Mortality Information System and the population data were obtained from the Brazilian Institute of Geography and Statistics. The trend of the rates standardized by sex and age was calculated using the Prais-Winsten estimation, and we obtained the annual percentage change and the respective 95% confidence intervals, analyzed according to sex, macroregion, and anatomical site. Read More

Laryngoscope 2018 09 2;128(9):2060-2066. Epub 2018 Feb 2.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Genoa, Genoa, Italy.

Objectives/hypothesis: There is no general consensus on what kind of examination to include in an optimal detection strategy for head and neck squamous cell carcinomas of unknown primary (SCCUPs). This study investigates the role of narrow-band imaging (NBI) in their identification.

Study Design: Case series. Read More

J Otolaryngol Head Neck Surg 2018 Jan 30;47(1). Epub 2018 Jan 30.

Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St, London, N6A 5C1, ON, Canada.

Background: HPV-related head and neck cancer rates have been increasing in recent years, with the tonsils being the most commonly affected site. However, the current rate of HPV infection in the pediatric population remains poorly defined. The objective of this study was to systematically review and evaluate the prevalence and distribution of HPV in the tonsils of pediatric patients undergoing routine tonsillectomy. Read More

Oral Oncol 2018 Feb 4;77:105-110. Epub 2018 Jan 4.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States. Electronic address:

Objective: To examine reader performance in evaluating oropharyngeal anatomy on ultrasonography.

Materials And Methods: Ultrasound images of the oropharynx comprising normal and malignant anatomic variants were organized into slideshows. Slideshows were administered to 6 readers blinded to participant tumor status and with varying experience reading oropharyngeal sonograms. Read More

Semin Cancer Biol 2018 10 31;52(Pt 2):228-240. Epub 2018 Jan 31.

Department of Medical Oncology, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3052, Australia.

Head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous group of tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and hypopharynx. While many HNSCCs are related to classical etiologic factors of smoking and alcohol, a clinically, genomically, and immunologically distinct subgroup of tumors arise from the epithelium of the tonsil and the base of tongue as a result of infection with Human Papilloma Virus (HPV). In this review we describe the genomic and immunologic landscape of HNSCC, highlighting differences between HPV-positive and HPV-negative HNSCC. Read More

PLoS One 2018 16;13(1):e0190709. Epub 2018 Jan 16.

Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Background: Radiation-therapy (RT) induces mucositis, a clinically challenging condition with limited prophylactic interventions and no predictive tests. In this pilot study, we applied global gene-expression analysis on serial human oral mucosa tissue and blood cells from patients with tonsil squamous cell cancer (TSCC) to identify genes involved in mucositis pathogenesis.

Methods And Findings: Eight patients with TSCC each provided consecutive buccal biopsies and blood cells before, after 7 days of RT treatment, and 20 days following RT. Read More

Mod Pathol 2018 05 12;31(5):732-743. Epub 2018 Jan 12.

Department of Lymphoid Malignancies, Maria Sklodowska-Curie Institute-Oncology Center, Warsaw, Poland.

We previously described a subset of MYC translocation-negative aggressive B-cell lymphomas resembling Burkitt lymphoma, characterized by proximal gains and distal losses in chromosome 11. In the 2016 WHO classification, these MYC-negative lymphomas were recognized as a new provisional entity, 'Burkitt-like lymphoma with 11q aberration'. Here we present an immunophenotype analysis of Burkitt-like lymphomas with 11q aberration. Read More

Int J Cancer 2018 06 21;142(12):2518-2528. Epub 2018 Jan 21.

Department of Otolaryngology - Head and Neck Surgery, CHUV, University of Lausanne, Lausanne, Switzerland.

HPV-positive head and neck squamous cell carcinoma (HNSCC) is increasingly frequent. Management is particularly debated in the case of postsurgical high-risk features, that is, positive surgical margins and extracapsular spread (ECS). In this increasingly complex emerging framework of HNSCC treatment, representative preclinical models are needed to support future clinical trials and advances in personalized medicine. Read More

Head Neck Pathol 2018 Dec 4;12(4):481-487. Epub 2018 Jan 4.

Department of Pathology, University of Alabama at Birmingham, 1802 6th Ave S, NP 3545, Birmingham, AL, 35233-7331, USA.

T cell lymphoma (TCL) is a group of rare and aggressive diseases. TCL primary to head and neck organs often present as extranodal NK/T cell lymphoma, nasal type. Systemic TCL with initial head and neck presentation is extremely rare. Read More

Ann Otol Rhinol Laryngol 2018 Feb 25;127(2):113-117. Epub 2017 Dec 25.

2 Department of Otolaryngology, Royal Children's Hospital, Melbourne, VIC, Australia.

Background: Unilateral tonsillar enlargement (UTE) is not an uncommon incidental finding. Lymphoma is the most common malignancy of the tonsils in children and presents with tonsillar enlargement.

Methods: This is a retrospective case series of all cases of histopathological analysis of tonsillectomy specimens at a single pediatric tertiary hospital between 1996 and 2015. Read More

PLoS Pathog 2017 12 21;13(12):e1006745. Epub 2017 Dec 21.

The Pirbright Institute, Ash Road, Woking, United Kingdom.

Marek's Disease Virus (MDV) is an alphaherpesvirus that infects chickens, transforms CD4+ T cells and causes deadly lymphomas. In addition, MDV induces immunosuppression early during infection by inducing cell death of the infected lymphocytes, and potentially due to activation of regulatory T (Treg)-cells. Furthermore, immunosuppression also occurs during the transformation phase of the disease; however, it is still unknown how the disease can suppress immune response prior or after lymphoma formation. Read More