3,003 results match your criteria Malignant Tumors of the Tonsil


Tuberculous Tonsillitis in a Patient Treated with an Anti-TNF Agent.

Eur J Case Rep Intern Med 2017 28;4(8):000690. Epub 2017 Jul 28.

Centro Hospitalar de S. João, Serviço de Medicina Interna, Porto, Portugal.

Tuberculosis remains a concern in patients receiving anti-TNF therapy as these individuals have a higher incidence of extrapulmonary and disseminated tuberculosis. Tuberculous tonsillitis is an unusual presentation of extrapulmonary tuberculosis, which is diagnosed mostly in immunodeficient patients. We report the case of a 33-year-old woman, diagnosed with Behçet's syndrome, immunosuppressed with adalimumab, cyclosporine and prednisolone. Read More

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http://dx.doi.org/10.12890/2017_000690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346858PMC

Fit for Cancer Treatment: a prospective feasibility study of primary care initiated prehabilitation for patients with suspected cancer.

BJGP Open 2018 Dec 17;2(4):bjgpopen18X101608. Epub 2018 Oct 17.

Consultant Surgeon and Head of Specialty School Surgery, Wales Post Graduate Medical and Dental Education Deanery School of Surgery, Cardiff University, Cardiff, UK.

Background: Risk profile assessment and corrective interventions using optimisation of health status and prehabilitation represent an important strategy in the management of patients with a suspected cancer diagnosis.

Aim: To determine the feasibility of pre-treatment optimisation and prehabilitation commenced at index primary care consultation, to improve patients' preparation for treatment by maximising the time available.

Design & Setting: Between January 2015 and May 2016, 195 patients presenting to 12 GP practices were deemed eligible to enter the study, of which 189 (96. Read More

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http://dx.doi.org/10.3399/bjgpopen18X101608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348330PMC
December 2018
2 Reads

A CARE-compliant article: Lymphangiomatous polyps of the palatine tonsils in a miner: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e14009

Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu.

Rationale: Lymphangiomatous polyps of the palatine tonsils are benign tumors that are rare in both adults and children. Most patients suffering from this disease present with nonspecific symptoms similar to those of chronic tonsillitis.

Patient Concern: We report a case of a 21-year-old male miner who presented with a chronic history of a foreign body sensation in the oropharynx and an intermittently sore throat. Read More

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http://dx.doi.org/10.1097/MD.0000000000014009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344164PMC
January 2019

Acceptable Weight Ranges for Research Tissue Procurement and Biorepositories, 2015-2017.

Biopreserv Biobank 2018 Oct 31. Epub 2018 Oct 31.

1 Ohio Consortium , Cooperative Human Tissue Network (CHTN) Midwestern Division, Columbus, Ohio.

Background: The Cooperative Human Tissue Network, Midwestern Division, is a National Cancer Institute-funded program that provides quality research biospecimens to qualified investigators. Consented human tissues are procured according to researcher specifications for weight (size) and preservation type; weights of samples in significant demand and limited supply are negotiated. Weights of procured tissues are entered into a dedicated biospecimen database. Read More

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http://dx.doi.org/10.1089/bio.2018.0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308276PMC
October 2018
3 Reads

Distribution of Metastatic Nodes in N0-1 Patients with Tonsillar Squamous Cell Carcinoma and Its Implications for Selective Neck Dissection.

Turk Arch Otorhinolaryngol 2018 Sep 1;56(3):139-144. Epub 2018 Sep 1.

Department of Head and Neck Surgery and Otorhinolaryngology, A. C. Camargo Cancer Center, São Paulo, Brazil.

Objective: We aimed to evaluate the pattern of neck metastasis in patients with primary tonsillar carcinoma treated by primary surgery and neck dissection. Impact of the extent of neck dissection and level of metastatic nodes on survival were also evaluated.

Methods: We evaluated 163 consecutive patients with tonsillar squamous cell carcinoma submitted for neck dissection and staged as cN0-1. Read More

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http://dx.doi.org/10.5152/tao.2018.3420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177493PMC
September 2018
1 Read

Malignant melanoma metastasizing to tonsil: A rare presentation.

J Cancer Res Ther 2018 Sep;14(Supplement):S815-S817

Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala, India.

Malignant melanoma (MM) has a high potential of lymphatic and hematogeneous spread, and metastatic disease is always incurable with a high mortality. We present a rare phenomenon of MM metastasizing to the palatine tonsil. Read More

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http://dx.doi.org/10.4103/0973-1482.206863DOI Listing
September 2018
2 Reads

Evaluation of two commercial CT metal artifact reduction algorithms for use in proton radiotherapy treatment planning in the head and neck area.

Med Phys 2018 Oct 19;45(10):4329-4344. Epub 2018 Sep 19.

Department of Medical Physics, Faculty of Medicine and Health, Örebro University, 70182, Örebro, Sweden.

Purpose: To evaluate two commercial CT metal artifact reduction (MAR) algorithms for use in proton treatment planning in the head and neck (H&N) area.

Methods: An anthropomorphic head phantom with removable metallic implants (dental fillings or neck implant) was CT-scanned to evaluate the O-MAR (Philips) and the iMAR (Siemens) algorithms. Reference images were acquired without any metallic implants in place. Read More

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http://dx.doi.org/10.1002/mp.13115DOI Listing
October 2018
1 Read

Study of adenotonsillectomy specimens: An institutional experience.

Ci Ji Yi Xue Za Zhi 2018 Jul-Sep;30(3):181-184

Department of Otolaryngology, Andaman and Nicobar Islands Institute of Medical Sciences, Port Blair, Andaman and Nicobar Islands, India.

Objective: Waldeyer's lymphatic ring consists of group of tonsils located over the posterior oropharyngeal wall. The palatine tonsils are largest tonsil. The present study was aimed to evaluate the significance of lymphoid hyperplasia, lymphocyte infiltration with and without defect in the surface epithelium in chronic tonsillitis (CT) and chronic adenotonsillar hypertrophy (CAH) in resected tonsillectomy and adenotonsillectomy specimens. Read More

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http://dx.doi.org/10.4103/tcmj.tcmj_133_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047327PMC
August 2018
18 Reads

Characteristic Histological Findings of Asymptomatic EBV-associated Lymphoproliferative Disorders in Tonsils.

J Clin Exp Hematop 2018 Sep 14;58(3):122-127. Epub 2018 Jul 14.

Recently, an in situ hybridization (ISH) and immunohistochemical study demonstrated that Epstein-Barr virus (EBV) infection may be involved in tonsillar hypertrophy and recurrent tonsillitis in children and young adolescents. The present study was based on 630 consecutive specimens from tonsillectomies performed at the Dokkyo University School of Medicine between 2002 and May 2017. Clinical findings were obtained from hospital records. Read More

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https://www.jstage.jst.go.jp/article/jslrt/58/3/58_18017/_ar
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http://dx.doi.org/10.3960/jslrt.18017DOI Listing
September 2018
4 Reads

Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway.

Nat Commun 2018 07 2;9(1):2570. Epub 2018 Jul 2.

Institut Curie, PSL Research University, INSERM, U932, 26 rue d'Ulm, 75005, Paris, France.

Presentation of exogenous antigens on MHC-I molecules, termed cross-presentation, is essential for cytotoxic CD8 T cell responses. In mice, dendritic cells (DCs) that arise from monocytes (mo-DCs) during inflammation have a key function in these responses by cross-presenting antigens locally in peripheral tissues. Whether human naturally-occurring mo-DCs can cross-present is unknown. Read More

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http://dx.doi.org/10.1038/s41467-018-04985-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028641PMC
July 2018
4 Reads

ALDH1A1 positive cells are a unique component of the tonsillar crypt niche and are lost along with NGFR positive stem cells during tumourigenesis.

Pathology 2018 Aug 8;50(5):524-529. Epub 2018 Jun 8.

School of Medical Diagnostic and Translational Sciences, College of Health Sciences, Old Dominion University, Norfolk, VA, United States. Electronic address:

Interest into the cellular biology of human tonsillar crypts has grown in recent years because it is now known to be the site of origin of most human papilloma virus (HPV) induced oropharyngeal squamous cell carcinomas (OPSCC). Despite the interest, still relatively little is known regarding the cellular hierarchy and dynamics of this anatomical subsite. Here we evaluate normal tonsillar crypts for expression of putative stem cell markers. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.03.002DOI Listing
August 2018
18 Reads

Is tonsillectomy mandatory for asymmetric tonsils in children? A review of our diagnostic tonsillectomy practice and the literature.

Int J Pediatr Otorhinolaryngol 2018 Jul 1;110:57-60. Epub 2018 May 1.

Otolaryngology Department, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool, L12 2AP, UK.

Introduction: Diagnostic tonsillectomy is performed to exclude malignancy. It is associated with a post-operative hemorrhage rate of 3.5%, (1) which is more dangerous in small children. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.04.027DOI Listing
July 2018
5 Reads

Survival outcome of tonsillar squamous cell carcinoma (TSCC) in the context of human papillomavirus (HPV): A systematic review and meta-analysis.

Surgeon 2019 Feb 26;17(1):6-14. Epub 2018 May 26.

Department of Otolaryngology and Head and Neck Surgery, Nepean Hospital, Sydney, NSW, Australia; University of Sydney, Sydney, NSW, Australia. Electronic address:

Objective: The objective of our study was to assess whether HPV-positive TSCC had better survival and prognosis rates, when compared to HPV-negative TSCC.

Method: A systematic review and meta-analysis was performed comparing HPV status in TSCC patients. TSCC was confirmed with histopathology and HPV status was confirmed with PCR, immunohistochemistry and/or in-situ-hybridisation. Read More

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http://dx.doi.org/10.1016/j.surge.2018.04.009DOI Listing
February 2019
17 Reads
2.210 Impact Factor

Asymmetric tonsils or tonsillar cancer?

Authors:
Paul G Fisher

J Pediatr 2018 06;197:3-4

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http://dx.doi.org/10.1016/j.jpeds.2018.04.018DOI Listing
June 2018
14 Reads

[Transoral resection of partial fistula wall to treat incomplete second branchial fistula: a case report].

Authors:
G C Zhu D J Xiao

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Aug;31(16):1298-1299

We describe a case of a 55-year-old man who presented with sore throat for two days, while neck swelling for one day, and was found to have a fistula in his left tonsil and an abscess in his left lateral pharyngeal wall with the lower bound to the upper border of the cricoid cartilage by ultrasonography and enhanced CT. The fistula from tonsillar fossa to hypopharynx was detected followed by left tonsillectomy, and then anterior wall of the fistula and mucosa covering it was resected. He was eventually diagnosed with incomplete second branchial fistula with infection, and was followed up for five years with no recurrence. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2017.16.020DOI Listing

[Clinical observation of coblation assisted transoral microsurgery for the treatment of oral and oropharygneal malignancy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Nov;31(22):1705-1710

Department of Otorhinolaryngology Head and Neck Surgery, Peking University First Hospital, Beijing, 100034, China.

To evaluate the feasibility and effectiveness of coblation assisted transoral surgery for the treatment of oral and oropharyngeal malignancy. 19 patients who suffered from oral or oropharyngeal malignant tumors underwent coblation assisted transoral surgery from August 2008 to August 2017 were studied. According to the tumor sites and pathological results, there were four oral squamous cell carcinoma (SCC) (two tongue carcinoma and two mouth floor carcinoma), eleven oropharygneal SCC (five tonsillar carcinoma, four soft palate carcinoma, one tongue base cartinama and one multiple carcinoma invading both soft palatine and hypopharynx), and four lymphatic and hematopoietic malignancies (three tonsillar tumors and one tumor invading both tonsil and tongue base). Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2017.22.001DOI Listing
November 2017
5 Reads

Health-related quality of life in oropharyngeal cancer survivors - a population-based study.

Otolaryngol Pol 2018 Apr;72(2):30-35

Department of Otorhinolaryngology, Head and Neck Surgery, Leer, Germany.

Objective: The aim of this study was to compare QoL of oropharyngeal cancer survivors who had received different treatments.

Subjects And Methods: We contacted 954 survivors. Each survivor received the QoL questionnaires EORTC QLQ-C30 and EORTC QLQ-H&N35. Read More

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http://dx.doi.org/10.5604/01.3001.0011.7249DOI Listing
April 2018
2 Reads

[Value of PET/CT in the prognosis of extranodal NK/T cell lymphoma].

Zhonghua Yi Xue Za Zhi 2018 Apr;98(16):1256-1260

Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.

To explore the value of Positron-Emission Tomography/Computed Tomography (PET/CT) in the prognosis of extranodal NK/T cell lymphoma. The patients of NK/T cell lymphoma diagnosed from January 2007 to July 2016 in Department of Pathology of Beijing Tongren Hospital were enrolled in this study. Seventy-two in-hospital patients were examined on the invasion of adjecent tissue or organ by PET/CT. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.16.014DOI Listing
April 2018
1 Read

HPV-related papillary squamous cell carcinoma of the tonsil during treatment with fingolimod.

Mult Scler Relat Disord 2018 Jul 2;23:24-26. Epub 2018 May 2.

Department of Otorhinolaryngology, Bussolengo Hospital, Verona, Italy. Electronic address:

Fingolimod is a commonly used treatment for highly active relapsing-remitting multiple sclerosis (MS). We describe the case of a 50-year old man on fingolimod since 2011 who presented, in April 2017, with a voluminous swelling of the left tonsil. A left tonsillectomy was performed, and histological exam disclosed a papillary squamous cell carcinoma of the palatine tonsil, with an in situ hybridization positive for human papillomavirus (HPV)-16 DNA. Read More

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http://dx.doi.org/10.1016/j.msard.2018.04.018DOI Listing
July 2018
4 Reads

Primary tonsillar mast cell tumour in a dog.

Aust Vet J 2018 May;96(5):184-187

QML Vetnostics, Murrarie, QLD, Australia.

Case Report: A 6-year-old speyed female Bull Arab-cross dog was found to have a small tonsillar nodule. Histological examination revealed a well-differentiated mast cell tumour (MCT). At initial staging, no evidence of concurrent cutaneous or visceral MCTs was found on a complete blood count, a single lateral thoracic radiograph, abdominal ultrasound or cytology of the spleen and regional lymph nodes. Read More

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http://dx.doi.org/10.1111/avj.12693DOI Listing
May 2018
3 Reads

Tonsillar Small Cell Carcinoma: Potential Contribution of Human Papillomavirus.

Am J Case Rep 2018 Apr 24;19:482-485. Epub 2018 Apr 24.

Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

BACKGROUND Extrapulmonary small cell carcinoma (SmCC) is a relatively rare clinical entity constituting only 2.5-5% of SmCCs. Recently, evidence has emerged that high-risk types of human papillomavirus (HPV) might play an etiologic role in oropharyngeal SmCC, similar to squamous cell carcinoma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937212PMC
April 2018
3 Reads

Surveillance of Tonsillar Cancer Incidence Rates in Minority Groups vs Non-Hispanic Whites in Large US Metropolitan Areas.

J Registry Manag 2017 ;44(2):54-61

BACKGROUND: For oropharyngeal (OP) cancers at anatomical sites regarded as related to human papillomavirus (HPV), surveillance using population-based cancer registries has shown that age-standardized incidence rates are higher in US non-Hispanic whites (NHWs) vs minority groups. Surveillance in large racially-ethnically diverse urban areas also should be considered. METHODS: Using the US Cancer Statistics database, age-standardized incidence rates per year were obtained for 2003–2013 for carcinomas of the tonsil, the OP site most strongly associated with HPV. Read More

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April 2018
14 Reads

Growth of the Epidemic of Human Papillomavirus-Related Oropharyngeal Carcinomas in Whites in Selected US Metropolitan and Nonmetropolitan Counties, 1992-2013.

J Registry Manag 2017 ;44(1):4-10

BACKGROUND: Age-standardized incidence rates (ASIRs) for US non-Hispanic whites (NHWs) have been increasing since 1999 for squamous cell carcinomas (SCC) at oropharyngeal (OP) anatomic sites strongly associated with human papillomavirus (HPV), as also reported from certain European countries. ASIRs declined slightly, however, from 2000–2006 to 2007–2012 in Stockholm County, Sweden (an urban area) for SCC of the tonsil (TSCC) but not base of tongue (BTSCC). For the United States, this study examined the growth of the epidemic of these cancers in 1992–2013. Read More

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April 2018
6 Reads

[Clinicopathologic characteristics and prognositic indicators of tonsillar mantle cell lymphoma].

Zhonghua Bing Li Xue Za Zhi 2018 Mar;47(3):158-162

Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

To investigate clinicopathological features and prognosis of tonsillar mantle cell lymphoma(TMCL). Clinical data of 25 patients with TMCL at Beijing Friendship Hospital, Capital Medical University from 2002 to 2016 were included. All the cases were reviewed microscopically. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.03.002DOI Listing
March 2018
1 Read

Marginal zone lymphoma of palatine tonsil with prominent plasmacytic differentiation: A CARE-compliant article and review of literature.

Medicine (Baltimore) 2018 Jan;97(2):e9648

Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.

Rationale: The palatine tonsil is an important component of Waldeyer's ring and a site commonly involved by lymphoma. Interestingly, although it is a site of mucosa-associated lymphoid tissue (MALT), primary MALT lymphoma of the palatine tonsil is rare, especially with prominent plasmacytic differentiation.

Patient Concerns: A 59-year-old woman presented to the hospital with a 1-month history of odynophagia. Read More

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http://Insights.ovid.com/crossref?an=00005792-201801120-0005
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000009648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943870PMC
January 2018
4 Reads

De novo mast cell leukemia without CD25 expression and KIT mutations: a rare case report in a 13-year-old child.

Diagn Pathol 2018 Feb 20;13(1):14. Epub 2018 Feb 20.

Department of Pathology, Peking University First Hospital, 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Background: Mast cell leukemia (MCL) is a very rare form of systemic mastocytosis (SM) and accounts for less than 0.5% of all mastocytosis. The diagnosis of MCL requires the presence of SM criteria, accompanied by leukemic infiltrating of atypical mast cells (MCs) in bone marrow (BM), peripheral blood as well as extracutaneous organs. Read More

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http://dx.doi.org/10.1186/s13000-018-0691-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819157PMC
February 2018
49 Reads

Neuroectodermally Derived Neoplasm of Tonsil: Difficulty in Histomorphological Diagnosis.

Indian J Otolaryngol Head Neck Surg 2018 Mar 21;70(1):159-161. Epub 2017 Jul 21.

Department of Pathology, Kovai Medical Center and Hospital, Coimbatore, Tamilnadu India.

Esthesioneuroblastomas are rare neuroectodermally derived neoplasms occurring in the upper nasal septum or cribriform plate. They have been rarely reported in other sites, when they are called ectopic esthesioneuroblastomas. Due to the scarcity of reports, publications and molecular/genetic studies of these tumours, their diagnosis is likely to be missed when they are ectopic. Read More

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http://dx.doi.org/10.1007/s12070-017-1172-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807285PMC
March 2018
2 Reads

Base of tongue cancer-is it tongue cancer located at the base of the tongue, or is it a type of lingual tonsil cancer? The perspective from a genomic analysis.

Int J Oral Maxillofac Surg 2018 Jul 13;47(7):846-853. Epub 2018 Feb 13.

Department of Otolaryngology-Head and Neck Surgery, Hallym University Medical Centre, Seoul, Republic of Korea. Electronic address:

The aim of this study was to determine whether base of tongue (BOT) cancer is tongue cancer located at the base of the tongue or lingual tonsil cancer originating from tonsil tissue. This was a retrospective study using data from The Cancer Genome Atlas (TCGA). The genomic patterns of three primary cancers (BOT, oral tongue, and tonsil) were compared to determine their similarities and differences. Read More

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http://dx.doi.org/10.1016/j.ijom.2018.01.017DOI Listing
July 2018
4 Reads

Hodgkin lymphoma involving the tonsil misdiagnosed as tonsillar carcinoma: A case report and review of the literature.

Medicine (Baltimore) 2018 Feb;97(7):e9761

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.

Rationale: Primary Hodgkin lymphoma (HL) involving the tonsil is extremely rare. Only about 20 such cases with verification of biopsy and immunohistochemistry have been reported. Because of its rarity and unremarkable clinical presentation, a timely correct diagnosis is very challenging. Read More

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http://dx.doi.org/10.1097/MD.0000000000009761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839833PMC
February 2018
3 Reads

Trend of oral and pharyngeal cancer mortality in Brazil in the period of 2002 to 2013.

Rev Saude Publica 2018 Feb 5;52:10. Epub 2018 Feb 5.

Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Epidemiologia. São Paulo, SP, Brasil.

Objective: To analyze the trend of oral and pharyngeal cancer mortality rates in the period of 2002 to 2013 in Brazil according to sex, anatomical site, and macroregion of the country.

Methods: The mortality data were obtained from the Mortality Information System and the population data were obtained from the Brazilian Institute of Geography and Statistics. The trend of the rates standardized by sex and age was calculated using the Prais-Winsten estimation, and we obtained the annual percentage change and the respective 95% confidence intervals, analyzed according to sex, macroregion, and anatomical site. Read More

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http://dx.doi.org/10.11606/S1518-8787.2018052000251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802649PMC
February 2018
1 Read

Role of narrow-band imaging in detection of head and neck unknown primary squamous cell carcinoma.

Laryngoscope 2018 09 2;128(9):2060-2066. Epub 2018 Feb 2.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Genoa, Genoa, Italy.

Objectives/hypothesis: There is no general consensus on what kind of examination to include in an optimal detection strategy for head and neck squamous cell carcinomas of unknown primary (SCCUPs). This study investigates the role of narrow-band imaging (NBI) in their identification.

Study Design: Case series. Read More

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http://dx.doi.org/10.1002/lary.27098DOI Listing
September 2018
5 Reads

The prevalence of human papillomavirus in pediatric tonsils: a systematic review of the literature.

J Otolaryngol Head Neck Surg 2018 Jan 30;47(1). Epub 2018 Jan 30.

Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St, London, N6A 5C1, ON, Canada.

Background: HPV-related head and neck cancer rates have been increasing in recent years, with the tonsils being the most commonly affected site. However, the current rate of HPV infection in the pediatric population remains poorly defined. The objective of this study was to systematically review and evaluate the prevalence and distribution of HPV in the tonsils of pediatric patients undergoing routine tonsillectomy. Read More

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http://dx.doi.org/10.1186/s40463-018-0255-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789580PMC
January 2018
8 Reads

Reader performance in the ultrasonographic evaluation of oropharyngeal carcinoma.

Oral Oncol 2018 Feb 4;77:105-110. Epub 2018 Jan 4.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States. Electronic address:

Objective: To examine reader performance in evaluating oropharyngeal anatomy on ultrasonography.

Materials And Methods: Ultrasound images of the oropharynx comprising normal and malignant anatomic variants were organized into slideshows. Slideshows were administered to 6 readers blinded to participant tumor status and with varying experience reading oropharyngeal sonograms. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2017.12.012DOI Listing
February 2018
8 Reads

Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.

Semin Cancer Biol 2018 10 31;52(Pt 2):228-240. Epub 2018 Jan 31.

Department of Medical Oncology, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3052, Australia.

Head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous group of tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and hypopharynx. While many HNSCCs are related to classical etiologic factors of smoking and alcohol, a clinically, genomically, and immunologically distinct subgroup of tumors arise from the epithelium of the tonsil and the base of tongue as a result of infection with Human Papilloma Virus (HPV). In this review we describe the genomic and immunologic landscape of HNSCC, highlighting differences between HPV-positive and HPV-negative HNSCC. Read More

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http://dx.doi.org/10.1016/j.semcancer.2018.01.008DOI Listing
October 2018
7 Reads

Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma.

PLoS One 2018 16;13(1):e0190709. Epub 2018 Jan 16.

Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Background: Radiation-therapy (RT) induces mucositis, a clinically challenging condition with limited prophylactic interventions and no predictive tests. In this pilot study, we applied global gene-expression analysis on serial human oral mucosa tissue and blood cells from patients with tonsil squamous cell cancer (TSCC) to identify genes involved in mucositis pathogenesis.

Methods And Findings: Eight patients with TSCC each provided consecutive buccal biopsies and blood cells before, after 7 days of RT treatment, and 20 days following RT. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190709PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770028PMC
February 2018
3 Reads

Mouse model of postsurgical primary tumor recurrence and regional lymph node metastasis progression in HPV-related head and neck cancer.

Int J Cancer 2018 06 21;142(12):2518-2528. Epub 2018 Jan 21.

Department of Otolaryngology - Head and Neck Surgery, CHUV, University of Lausanne, Lausanne, Switzerland.

HPV-positive head and neck squamous cell carcinoma (HNSCC) is increasingly frequent. Management is particularly debated in the case of postsurgical high-risk features, that is, positive surgical margins and extracapsular spread (ECS). In this increasingly complex emerging framework of HNSCC treatment, representative preclinical models are needed to support future clinical trials and advances in personalized medicine. Read More

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http://dx.doi.org/10.1002/ijc.31240DOI Listing
June 2018
25 Reads

Targeted Tonsillar Biopsy for Unilateral Tonsillar Enlargement.

Ann Otol Rhinol Laryngol 2018 Feb 25;127(2):113-117. Epub 2017 Dec 25.

2 Department of Otolaryngology, Royal Children's Hospital, Melbourne, VIC, Australia.

Background: Unilateral tonsillar enlargement (UTE) is not an uncommon incidental finding. Lymphoma is the most common malignancy of the tonsils in children and presents with tonsillar enlargement.

Methods: This is a retrospective case series of all cases of histopathological analysis of tonsillectomy specimens at a single pediatric tertiary hospital between 1996 and 2015. Read More

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http://dx.doi.org/10.1177/0003489417749252DOI Listing
February 2018
10 Reads

Association of Marek's Disease induced immunosuppression with activation of a novel regulatory T cells in chickens.

PLoS Pathog 2017 12 21;13(12):e1006745. Epub 2017 Dec 21.

The Pirbright Institute, Ash Road, Woking, United Kingdom.

Marek's Disease Virus (MDV) is an alphaherpesvirus that infects chickens, transforms CD4+ T cells and causes deadly lymphomas. In addition, MDV induces immunosuppression early during infection by inducing cell death of the infected lymphocytes, and potentially due to activation of regulatory T (Treg)-cells. Furthermore, immunosuppression also occurs during the transformation phase of the disease; however, it is still unknown how the disease can suppress immune response prior or after lymphoma formation. Read More

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http://dx.doi.org/10.1371/journal.ppat.1006745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739506PMC
December 2017
7 Reads

Quality indicators of oropharyngeal cancer care in the elderly.

Laryngoscope 2018 Oct 15;128(10):2312-2319. Epub 2017 Dec 15.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at John Hopkins, Baltimore, Maryland, U.S.A.

Objective: To examine associations between quality of care, survival, and costs in elderly patients treated for oropharyngeal squamous cell cancer (OPSCC).

Study Design: Retrospective analysis of Surveillance, Epidemiology, and End Results-Medicare data.

Methods: We evaluated 666 patients diagnosed with OPSCC from 2004 to 2007 using multivariate regression and survival analysis. Read More

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http://dx.doi.org/10.1002/lary.27050DOI Listing
October 2018
8 Reads

Quantitative Analysis of a Multiplexed Immunofluorescence Panel in T-Cell Lymphoma.

SLAS Technol 2018 06 14;23(3):252-258. Epub 2017 Dec 14.

3 Cancer Science Institute of Singapore, National University of Singapore, Singapore.

Immunohistochemistry (IHC) provides clinically useful information on protein expression in cancer cells. However, quantification of colocalizing signals using conventional IHC and visual scores is challenging. Here we describe the application of quantitative immunofluorescence in angioimmunoblastic T-cell lymphoma (AITL), a peripheral T-cell lymphoma characterized by cellular heterogeneity that impedes IHC interpretation and quantification. Read More

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http://dx.doi.org/10.1177/2472630317747197DOI Listing
June 2018
16 Reads

High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization.

Immunity 2017 12 5;47(6):1037-1050.e6. Epub 2017 Dec 5.

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Given the limited efficacy of clinical approaches that rely on ex vivo generated dendritic cells (DCs), it is imperative to design strategies that harness specialized DC subsets in situ. This requires delineating the expression of surface markers by DC subsets among individuals and tissues. Here, we performed a multiparametric phenotypic characterization and unbiased analysis of human DC subsets in blood, tonsil, spleen, and skin. Read More

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http://dx.doi.org/10.1016/j.immuni.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738280PMC
December 2017
22 Reads

Interobserver reliability of computed tomographic contouring of canine tonsils in radiation therapy treatment planning.

Vet Radiol Ultrasound 2018 May 4;59(3):357-364. Epub 2017 Dec 4.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907.

In radiation therapy (RT) treatment planning for canine head and neck cancer, the tonsils may be included as part of the treated volume. Delineation of tonsils on computed tomography (CT) scans is difficult. Error or uncertainty in the volume and location of contoured structures may result in treatment failure. Read More

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http://dx.doi.org/10.1111/vru.12584DOI Listing
May 2018
1 Read

Multifocal human papillomavirus detection in palatine and pharyngeal tonsils.

Acta Otolaryngol 2018 May 29;138(5):483-486. Epub 2017 Nov 29.

b Department of Otolaryngology-Head and Neck Surgery , Kanazawa University , Kanazawa , Japan.

Background: Multifocal human papillomavirus (HPV) infection into the palatine and pharyngeal tonsils, which might be linked to a second primary tumor of HPV-positive oropharyngeal cancer (OPC), was investigated.

Patients And Methods: One hundred and five patients with various head and neck diseases including 14 patients with OPC were enrolled in this study. Swabs from the palatine and pharyngeal tonsils were collected in each individual, and auto-nested GP5+/GP6+ PCR for HPV DNA was performed. Read More

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http://dx.doi.org/10.1080/00016489.2017.1408143DOI Listing
May 2018
12 Reads

Tuberculosis of the tonsil simulating a cancer.

Lancet Infect Dis 2017 12;17(12):1317

Department of Otorhinolaryngology-Head and Neck Surgery, Habib Bourguiba University Hospital, Sfax Medical School, University of Sfax, Sfax, Tunisia.

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http://dx.doi.org/10.1016/S1473-3099(17)30315-8DOI Listing
December 2017
3 Reads

Comparison of the mRNA expression profile of B-cell receptor components in normal CD5-high B-lymphocytes and chronic lymphocytic leukemia: a key role of ZAP70.

Cancer Med 2017 Dec 10;6(12):2984-2997. Epub 2017 Nov 10.

Biological Department, M.V. Lomonosov Moscow State University, Moscow, Russia.

The B-cell receptor (BCR) signaling pathway is of great importance for B-cell survival and proliferation. The BCR expressed on malignant B-CLL cells contributes to the disease pathogenesis, and its signaling pathway is currently the target of several therapeutic strategies. Although various BCR alterations have been described in B-CLL at the protein level, the mRNA expression levels of tyrosine kinases in B-CLL compared to that in normal CD5-high and CD5-low B-lymphocytes remain unknown. Read More

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http://dx.doi.org/10.1002/cam4.1257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727315PMC
December 2017
21 Reads

40-year incidence trends for oropharyngeal squamous cell carcinoma in the United States.

Oral Oncol 2017 11 2;74:90-97. Epub 2017 Oct 2.

Department of Otolaryngology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States.

Objectives: To determine differences in oropharyngeal squamous cell carcinoma (OPSCC) incidence between 1975 and 2014 stratified by race, sex, and age.

Materials And Methods: We obtained age-adjusted OPSCC incidence rates for race and sex groups from 1975 to 2014 using the Surveillance, Epidemiology, and End Results 9 database. We defined OPSCC as cancers of the base of tongue, lingual/palatine tonsil, oropharynx, soft palate, uvula, and Waldeyer's ring. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2017.09.015DOI Listing
November 2017
8 Reads

Synchronous, bilateral tonsillar carcinomas: Patient characteristics and human papillomavirus genotypes.

Oral Oncol 2017 11 3;74:105-110. Epub 2017 Oct 3.

Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Denmark. Electronic address:

Introduction: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing, but data on the incidence of synchronous, bilateral tonsillar squamous cell carcinomas (BiTSCCs) is sparse. In this study, we report the incidence and tumour characteristics of BiTSCCs in a population-based, consecutive cohort of OPSCCs.

Methods: We identified all patients diagnosed with tonsillar squamous cell carcinoma (TSCC) in eastern Denmark during a 15-year period to detect the incidence of synchronous BiTSCCs. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2017.09.019DOI Listing
November 2017
16 Reads

Anti-PD1/PDL1 induced psoriasis.

Curr Probl Cancer 2017 Nov - Dec;41(6):407-412. Epub 2017 Oct 18.

Dermato Oncology Department, Cutaneous Toxicities Clinic, Andreas Sygros Hospital, University of Athens, Athens, Greece.

Background: Immune checkpoint inhibitors are novel agents approved for the treatment of late-stage malignancies. Despite its important clinical benefits, checkpoint inhibition is associated with a unique spectrum of side effects known as immune-related adverse events. Skin toxicities are the most frequent immune-related adverse events during anti-PD1 blockade therapies. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2017.10.003DOI Listing
July 2018
6 Reads

Critical Weight Loss in Patients With Oropharynx Cancer During Radiotherapy (± Chemotherapy).

Nutr Cancer 2017 Nov-Dec;69(8):1211-1218. Epub 2017 Oct 30.

a Department of Radiation Oncology , The Prince of Wales Hospital Cancer Centre , Randwick , New South Wales , Australia.

Critical weight loss (CWL) defined as ≥5% in one month, is common in patients with oropharynx cancer and identification of patients at risk is challenging. We aimed to investigate if predictors of CWL in this population exist to guide nutritional intervention. Data were collected retrospectively on 134 patients who had radiotherapy (RT) ± concurrent chemotherapy (CRT) ± surgery. Read More

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http://dx.doi.org/10.1080/01635581.2017.1367943DOI Listing

Cytokeratin7 expression in histologic and cytologic specimens of cystic neck metastasis from HPV positive squamous cell carcinoma of the tonsil: A case report.

Diagn Cytopathol 2018 Apr 19;46(4):331-335. Epub 2017 Oct 19.

Department of Pathology, Nowon Eulji Medical Center, Eulji University, Seoul, Korea.

The majority of cystic squamous cell carcinomas (SCCs) of the neck have been shown to be metastatic tumors from tonsillar SCCs associated with high-risk human papillomavirus (HR HPV). Recent studies have demonstrated cytokeratin (CK)7 involvement in the development of HPV positive SCC, but no report has been issued on its simultaneous expression in primary tonsillar and metastatic tumor with cystic change. We present a case of HPV positive tonsillar SCC of a 42-year-old male that initially manifested as a cystic neck mass expressing CK7, CK19, and p16 in primary and metastatic tumors. Read More

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http://dx.doi.org/10.1002/dc.23841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873402PMC
April 2018
7 Reads