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Oral Oncol 2020 May 21;108:104806. Epub 2020 May 21.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Objectives: To find out the role of resection margin involvement in surgically managed HPV-positive tonsil cancer.

Materials And Methods: The study included 94 subjects with HPV-positive tonsil cancer undergoing surgical treatment. We evaluated the relationships between the resection margin status, clinicopathological factors, and oncological outcome. Read More

Medicine (Baltimore) 2020 May;99(18):e19793

Department of Otorhinolaryngology - Head and Neck Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, South Korea.

Rationale: Many previous studies have investigated the necessity of routine histopathological analysis of tonsillectomy specimen, and most recent studies have suggested that such an analysis is not justified in asymptomatic patients or those with no risk factors for malignancy.

Patient Concerns: A 59-year-old man diagnosed with obstructive sleep apnea underwent surgery, including tonsillectomy; a tonsil specimen was sent to the department of pathology.

Diagnosis: Although the patient did not exhibit any tonsil-related signs or symptoms, nor did the appearance of the tonsil appear to be pathological, the right tonsil specimen was diagnosed with squamous cell carcinoma, with detection of human papilloma virus 16. Read More

Vet Comp Oncol 2020 Apr 30. Epub 2020 Apr 30.

Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, USA.

Tonsillar metastasis from distant primary tumours has not been described in dogs, and reports are rare in humans. The aims of this study were to determine whether tumour metastasis occurs to the canine palatine tonsils and evaluate whether afferent lymphatics drain to the palatine tonsils via skull indirect computed tomography lymphangiography (ICTL). Retrospective review of the diagnostic laboratory tonsillar histopathology submissions was performed. Read More

MMWR Morb Mortal Wkly Rep 2020 Apr 17;69(15):433-438. Epub 2020 Apr 17.

Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC.

Cancers of the oral cavity and pharynx account for 3% of cancers diagnosed in the United States* each year. Cancers at these sites can differ anatomically and histologically and might have different causal factors, such as tobacco use, alcohol use, and infection with human papillomavirus (HPV) (1). Incidence of combined oral cavity and pharyngeal cancers declined during the 1980s but began to increase around 1999 (2,3). Read More

Zhonghua Zhong Liu Za Zhi 2020 Mar;42(3):247-251

Medical Affairs Office, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To investigate the causes and influencing factors of unplanned reoperation in head and neck neoplasms. A retrospective analysis was conducted on the clinical data of the operation treated patients with head and neck neoplasm in Cancer Hospital Chinese Academy of Medical Sciences from 2016 to 2018. Among 15 113 cases of head and neck neoplasms, 122 cases underwent unplanned reoperation, with an incidence of 0. Read More

J Laryngol Otol 2020 Apr 1;134(4):369-371. Epub 2020 Apr 1.

Department of Otolaryngology, Royal Devon and Exeter NHS Foundation Trust, UK.

Objective: This paper presents a case of an isolated pituitary fossa metastasis on a background of a previously treated tonsillar squamous cell carcinoma.

Case Report: A 64-year-old male, diagnosed with a primary p16-negative squamous cell carcinoma in the right tonsil, was treated with a course of chemoradiotherapy with curative intent. Positron emission tomography/computed tomography, performed at six months post-treatment, revealed a good local response and no distant metastases. Read More

Otolaryngol Head Neck Surg 2020 May 10;162(5):693-701. Epub 2020 Mar 10.

Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA.

Objective: Extranodal extension (ENE) is known to be associated with poor outcomes in head and neck squamous cell carcinoma. The objective of this study is to examine the impact of extent of ENE on survival in oropharyngeal carcinoma in the human papillomavirus (HPV) era.

Study Design: Retrospective database review. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;34(2):183-185

Sarcomatoid carcinoma, a malignant tumor containing both epithelial-derived malignant cells and malignant mesenchymal cells. Microscopically, cancer cells and sarcoma cells migrate to each other, and CK and Vimentin are simultaneously expressed. A rare case of tonsillar sarcomatoid carcinoma is discussed in our department with dysphagia as the first symptom. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;55(2):109-115

Department of Otorhinolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

To evaluate the indication, safety and effectiveness of transoral robotic surgery (TORS) for oropharyngeal cancer based on our preliminary experience. Twelve patients, including six with tonsil cancer, five with tongue base cancer and one with posterior pharyngeal wall cancer, who underwent TORS with Da Vinci Si surgical system from March 2017 to October 2018 at Tongji Hospital of Huazhong University of Science Technology were respectively analyzed. And the surgical time, intraoperative blood loss, postoperative local bleeding, dyspnea, nerve function injury, oral intake time, whether or not to receive chemoradiotherapy were analyzed. Read More

Rinsho Ketsueki 2020 ;61(1):33-38

Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University.

CD20 antigen is an important marker for diagnosis of B-cell neoplasms that is highly expressed on the surface of neoplastic B lymphocytes. Patients with rheumatoid arthritis (RA) have an increased risk of developing malignant lymphoma, of which diffuse large B-cell lymphoma (DLBCL) is the most common type. We report an unusual case of CD20-negative DLBCL complicated by rheumatoid arthritis. Read More

Medicine (Baltimore) 2020 Jan;99(2):e18670

Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.

This retrospective study is to explore the clinicopathologic, immunophenotypic, and molecular genetic features of Waldeyer ring B-cell lymphoma (WR-BCL).Tissue arrays from 65 WR-BCL cases were subjected to pathologic and immunophenotypic detections. Expression of Epstein-Barr virus-encoded small RNA (EBER) was detected by in situ hybridization. Read More

Oncology 2020 17;98(3):179-185. Epub 2019 Dec 17.

Division of Hematology and Oncology, UT Southwestern Medical Center, Dallas and Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas, USA,

Background: HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC) demonstrates favorable outcomes compared to HPV-negative SCC, but distant metastases (DM) still occur. The pattern of DM in HPV+ HNSCC is unclear.

Methods: 1,494 HNSCC patients were treated from 2006 to 2012. Read More

Chest 2019 12;156(6):e121-e126

Division of Pulmonary and Critical Care Medicine, Weill Department of Medicine, Weill Cornell Medicine, New York, NY. Electronic address:

Case Presentation: A man in his 20s presented to the ED after several months of progressive dyspnea, dry cough, and night sweats. He had no chest pain, fevers, weight loss, or sick contacts. He was previously healthy and took no medications. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 11;54(11):863-864

Department of Pathology, Zhuji People's Hospital of Zhejiang Province, Zhuji 311800, China.

Vestn Otorinolaringol 2019 ;84(5):73-75

Otorhinolaryngology department of the pediatric department of Pirogov Russian National Research Medical University, Moscow, Russia, 117997.

Lymphangiomatous polyps of palatine tonsils are a rare condition, which is diagnosed with patomorphological study. About cases in total are reported in the literature, mostly with one-sided lesions. We managed to find only two reports of lymphangiomatous polyps of palatine tonsils in the available literature. Read More

Vestn Otorinolaringol 2019 ;84(5):32-37

The Sverzhevskiy's Otorhinolaryngology Healthcare Research Institute, Moscow, Russia, 117152.

The authors studied the reporting documentation of otorhinolaryngological hospitals of the city of Moscow on the surgical treatment of pharyngeal pathology in adults from 2002 to 2017. It was found that for 16 years surgical treatment of 290 362 patients with ENT-diseases was performed: 181.206 (62. Read More

Oral Oncol 2020 01 22;100:104475. Epub 2019 Nov 22.

Massachusetts Eye and Ear, Boston, MA, United States; Harvard Medical School, Boston, MA, United States. Electronic address:

Objectives: HPV mediated head and neck squamous cell carcinoma (HPVmHNSCC) is increasing in prevalence in the United States, as are reports of patients with multiple HPVmHNSCCs. The prevalence, demographics, and treatment implications of this emerging clinical entity are poorly understood.

Materials And Methods: We performed a multitiered assessment of patients with multiple HPVmHNSCC including: 1. Read More

Pan Afr Med J 2019 2;34. Epub 2019 Sep 2.

Department of Otorhinolaryngology and Head and Neck Surgery at "Fattouma Bourguiba" Hospital of Monastir, Tunisia.

Epidermoid cysts (ECs) are benign lesions that can be encountered throughout the body, but with a low incidence in the head and neck (1.6 to 7%). In oral cavity, the most common affected site is floor of the mouth, but tonsillar location remains extremely rare (less than 0. Read More

Gan To Kagaku Ryoho 2019 Nov;46(11):1775-1778

Dept. of Hematology, Kanto Rosai Hospital.

A woman in her early 60s noticed bilateral breast masses and visited a different hospital. Core needle biopsy showed diffuse large B-cell lymphoma of the right breast and invasive ductal carcinoma of the left breast. After referral to our department, PET-CT was performed. Read More

J Otolaryngol Head Neck Surg 2019 Nov 12;48(1):62. Epub 2019 Nov 12.

Department of Pathology, Anatomy and Laboratory Medicine, West Virginia University, 1 Medical Center Drive, Health Sciences North, Rm 4054, Morgantown, WV, 26506, USA.

Background: Transoral robotic and laser surgery is rising in popularity due to the increasing incidence of Human Papilloma Virus (HPV) related oropharyngeal cancer. However, adequate exposure of the tongue base remains a major hurdle in many cases. This study introduces a novel surgical technique called the Floor of Mouth Window, which can be used to improve tongue base exposure at the time of transoral surgery. Read More

Aerosp Med Hum Perform 2019 Nov;90(11):978-981

Although oropharyngeal squamous cell papilloma (OSCP) is not uncommon in the general population, reports of OSCP in aviators are rare. This case report serves as a call for flight surgeons to consider all oropharyngeal pathology as a potential source of airway compromise during flight, and highlights regional risk factors for developing malignancies of the oropharynx. A 24-yr-old male foreign national student aviator from a central Asian country was at Fort Rucker for flight training. Read More

Sci Adv 2019 10 9;5(10):eaax5851. Epub 2019 Oct 9.

Department of Pathology, Stanford University, Stanford, CA.

Understanding tissue structure and function requires tools that quantify the expression of multiple proteins while preserving spatial information. Here, we describe MIBI-TOF (multiplexed ion beam imaging by time of flight), an instrument that uses bright ion sources and orthogonal time-of-flight mass spectrometry to image metal-tagged antibodies at subcellular resolution in clinical tissue sections. We demonstrate quantitative, full periodic table coverage across a five-log dynamic range, imaging 36 labeled antibodies simultaneously with histochemical stains and endogenous elements. Read More

Br J Radiol 2019 Dec 15;92(1104):20190466. Epub 2019 Oct 15.

Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Objective: One approach to reduce treatment-related morbidity for human papilloma virus (HPV)-associated tonsil cancer is omitting radiotherapy to the contralateral neck. Pathologic risk factors for early contralateral neck disease, however, are poorly understood. We report on the risk contralateral neck failures from the time of pre-operative diagnostic imaging to time of planning for adjuvant radiation in a single institution series of HPV-associated tonsillar cancer patients undergoing surgery followed by radiotherapy (RT). Read More

Yonago Acta Med 2019 Sep 13;62(3):258-262. Epub 2019 Sep 13.

Division of Pathology, Tohoku Medical and Pharmaceutical University, Sendai 981-0905, Japan.

Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin cancer. To diagnose nodal MCC with an unknown primary disease is challenging, and it has to be separated from other nodal metastatic neoplasms. We report a unique case of nodal MCC in head and neck lesions with an unknown primary. Read More

J Oral Pathol Med 2020 Feb 29;49(2):145-149. Epub 2019 Sep 29.

Oral & Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.

Background: Multiple squamous cell carcinoma (SCC) development within the oral cavity is an important consequence of mucosal field cancerization. We have previously profiled contemporaneous demographics and confirmed a rising incidence of oral cancer within the Hong Kong population. In this further study, we sought to characterize the presenting clinico-pathological features and clinical outcome consequent upon multiple primary tumour (PT) development. Read More

Zhonghua Bing Li Xue Za Zhi 2019 09;48(9):728-729

Department of Pathology, the First Hospital of Jilin University, Changchun 130021, China.

Cancer Sci 2019 Sep 28;110(9):2722-2733. Epub 2019 Aug 28.

Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

Mesothelin (MSLN) shows increased expression in various cancer cells. For clinical application of antibodies as a positron emission tomography (PET) imaging reagent, a human shortened antibody is essential both for avoiding redundant immune responses and for providing rapid imaging. Therefore, we cloned a single-chain fragment of variable regions (scFv) from a human-derived gene sequence. Read More

Cancer Cell 2019 09 22;36(3):237-249.e6. Epub 2019 Aug 22.

Department of Medicine, Division of Hematology, Miller School of Medicine, University of Miami, 1600 NW 10th Avenue/1475 NW 12th Avenue (D8-4), Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA; Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, Miami, FL, USA. Electronic address:

Deficiency in DNA double-strand break (DSB) repair mechanisms has been widely exploited for the treatment of different malignances, including homologous recombination (HR)-deficient breast and ovarian cancers. Here we demonstrate that diffuse large B cell lymphomas (DLBCLs) expressing LMO2 protein are functionally deficient in HR-mediated DSB repair. Mechanistically, LMO2 inhibits BRCA1 recruitment to DSBs by interacting with 53BP1 during repair. Read More

BMC Cancer 2019 Aug 14;19(1):801. Epub 2019 Aug 14.

Medical Oncologist, Mangalore Institute of Oncology, Mangalore, Karnataka, India.

Background: Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms. Solitary plasmacytomas are rarer entities accounting for less than 5% of all the plasma cell dyscrasias. They encompass three subtypes - Solitary Plasmacytoma of Bone (SPB) and Solitary Extramedullary Plasmacytoma (SEP) and multiple solitary plasmacytomas (MSP). Read More

BMJ Case Rep 2019 Aug 6;12(8). Epub 2019 Aug 6.

Pathology and Lab Medicine, All India Institute of Medical Sciences, Bhubaneswar, India.

Benign tumours of the tonsils are rare. Majority of these lesions are diagnosed as squamous papilloma. Hamartoma is a benign tumor-like malformation. Read More

N Engl J Med 2019 Jul;381(4):e8

University of Chicago, Chicago, IL

Arkh Patol 2019 ;81(3):12-18

Department of Oncology with Course of Thoracic Surgery, Faculty for Advanced Training and Professional Retraining of Specialists, Kuban State Medical University, Ministry of Health of Russia, Krasnodar, Russia; Prof. S.V. Ochapovsky Territorial Clinical Hospital One, Research Institute, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia.

Objective: To identify the expression of the molecular markers p53 and p16INK4A in head and neck squamous cell carcinoma (HNSCC) and to assess their impact on its clinical and morphological characteristics and overall survival (OS) rates in patients with HNSCC.

Material And Methods: Histological blocks were immunohistochemically studied using anti-p16 and p53 monoclonal antibodies in Krasnodar Clinical Oncology Dispensary One in 2011 to 2016. Overexpression of p16INK4A was established in the presence of 3 and 4 staining points (nuclear and/or cytoplasmic staining in 40% or more tumor cells). Read More

Vet Clin Pathol 2019 Sep 6;48(3):429-434. Epub 2019 Jul 6.

Synergy Animal General Hospital, Kawaguchi-shi, Saitama, Japan.

A 13-year-old spayed female Pomeranian dog was presented for persistent, severe hypoglycemia (37 mg/dL; reference interval [RI] 75-128 mg/dL). Progressive nonregenerative anemia (hematocrit 23.3%-15. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jun;54(6):466-468

Department of Imaging Diagnosis, Second Affiliated Hospital of Suzhou University, Suzhou 215008, China.

Ochsner J 2019 ;19(2):181-183

Department of Otolaryngology - Head and Neck Surgery, Tulane University School of Medicine, New Orleans, LA.

Metastatic melanoma to the mucosa of the upper aerodigestive tract is extremely rare, accounting for <0.6% of known metastasis to the head and neck region. We present a case of delayed metastatic melanoma to the pharyngeal tonsil. Read More

Head Neck 2019 09 28;41(9):3468-3469. Epub 2019 Jun 28.

GenesisCare Radiation Oncology, Division Radiation Oncology, St. Vincent's Hospital, Melbourne, Australia.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Sep 17;136(4):331-333. Epub 2019 Jun 17.

Service Hospitalo -Universitaire d'ORL et Chirurgie cervico-faciale, CHU de Grenoble - Alpes (CHUGA), France; Faculté de médecine, Universités des Alpes, Grenoble, France; UGA/UMR/CNRS 5309/Inserm 1209, Institut Albert-Bonniot, Grenoble, France.

Am J Otolaryngol 2019 Sep - Oct;40(5):673-677. Epub 2019 Jun 4.

Department of Radiation Medicine, College of Medicine, University of Kentucky, Lexington, KY, United States of America. Electronic address:

Purpose: Optimal treatment strategies for the management of oropharyngeal squamous cell carcinoma (OPSCC) remain unclear. The objective of this study is to examine the role of transoral robotic surgery (TORS) on functional and treatment outcomes.

Materials And Methods: A retrospective review of patients with OPSCC (tonsil/base of tongue) who underwent TORS with neck dissection± adjuvant therapy between January 2011 to December 2016 were compared to a stage matched cohort of patients treated with primary chemoradiation. Read More

Clin Nucl Med 2019 Oct;44(10):812-814

From the Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital.

A 70-year-old man with cerebellar syndromes was clinically diagnosed as paraneoplastic cerebellar degeneration and underwent whole-body F-FDG PET/CT imaging for screening primary tumor. Intensely elevated tracer uptake in both cerebellar hemispheres was revealed, whereas no abnormality was found in MRI. Increased tracer uptake and swelling of the left tonsil and a cervical lymph node were found at the same time, suggesting neoplasm in tonsil with lymph node metastasis. Read More

Cancer Epidemiol 2019 08 31;61:89-94. Epub 2019 May 31.

Department of Biopathology, University Hospital of Montpellier, France.

Background: France has one of the highest incidence of head and neck cancers in Europe. Despite this, the epidemiological impact of high-risk human papilloma virus (HR-HPV) remains poorly investigated.

Methods: We prospective assessed the proportion of oropharyngeal cancers due to HR-HPV in 15 hospitals throughout France. Read More

BMJ Case Rep 2019 May 30;12(5). Epub 2019 May 30.

Department of Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK.

A 34-year-old HIV-positive man presented in clinic with generalised erythroderma, having been lost to follow-up for the previous 3 years. He was CD4 lymphopenic (100×10/L) and was antiretroviral therapy naive. Initial histology from a skin punch biopsy was non-specific and he was treated with topical steroids and emollients for a suspected eczema. Read More

Medicine (Baltimore) 2019 May;98(22):e15763

Pathology Center, Chi Mei Medical Center, Tainan, Taiwan.

Rationale: Palatine tonsil is an extremely rare site for metastatic disease, accounting for 0.8% of malignant tonsillar neoplasms. To the best of our knowledge, this is the first report of metastatic adenocarcinoma in the tonsil treated with wide excision and targeted therapy, with no local recurrence 6 months postoperatively. Read More

Am J Otolaryngol 2019 Jul - Aug;40(4):567-572. Epub 2019 May 15.

Department of Otolaryngology - Head and Neck Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, United States of America.

Background: Since most HPV-associated disease occurs in the tonsillar-related areas (TRA) - palatine and lingual tonsils, the effect of HPV on survival in non-tonsillar oropharyngeal subsites (nTRA) is not well established. The objective of this study was to use a large population-based cohort to investigate the survival impact of HPV in nTRA subsites versus TRA subsites.

Methods: This SEER database study was conducted by stratifying the HPV-positive oropharyngeal cancer cohort into two primary groups, TRA and nTRA. Read More

Oral Oncol 2019 06 1;93:96-100. Epub 2019 May 1.

University of Toronto, Department of Otolaryngology - Head & Neck Surgery, Princess Margaret Cancer Center, 610 University Avenue, 3-955, Toronto, ON M5G 2M9, United States; Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada. Electronic address:

Background: Knowledge of the rate of occult contralateral nodal disease for oropharynx cancers (OPSCC) in the era of Human Papillomavirus-dominated disease would inform practitioners as to who may be a candidate for unilateral neck management. The objective of this study was to determine the rate of pathologic contralateral positive nodes in patients in OPSCC patients with pT1 and pT2 disease treated with TORS and bilateral neck dissections (BND).

Methods: Retrospective review of medical records was performed at Princess Margaret Cancer Center, Toronto; Icahn School of Medicine at Mount Sinai, New York City; and Montefiore Medical Center, New York City. Read More

Zhonghua Bing Li Xue Za Zhi 2019 May;48(5):358-363

Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

To investigate the clinicopathological features of long-term tumor-free survival in patients with untreated primary diffuse large B-cell lymphoma (DLBCL) of the tonsil. The study included 80 consultation cases of primary tonsillar DLBCL from April 2006 to July 2017 in the Department of Pathology, Beijing Friendship Hospital, Capital Medical University. The patients were divided into two groups: experimental groups of 10 untreated patients with long-term tumor-free survival, and 70 patients who had been treated (control group). Read More

Int J Cancer 2019 12 30;145(11):3152-3162. Epub 2019 May 30.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.

The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been increasing due to high-risk HPV infection. We explored the significance of genetic alterations in HPV-positive (HPV-P) and HPV-negative (HPV-N) OPSCC patients on long-term outcome. A total of 157 cases of primary resected OPSCC diagnosed from 1978 to 2005 were subjected to a targeted exome sequencing by MSK-IMPACT™ interrogating somatic mutations in 410 cancer-related genes. Read More

BMC Fam Pract 2019 05 14;20(1):62. Epub 2019 May 14.

The Copenhagen Primary Care Laboratory (CopLab) Database, Section of General Practice and The Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Background: General practitioners encounter the vast majority of patients with Epstein-Barr virus-related disease, i.e. infectious mononucleosis in children and adolescents. Read More

Otolaryngol Head Neck Surg 2019 09 14;161(3):536-538. Epub 2019 May 14.

1 Department of Otolaryngology-Head and Neck Surgery, Washington University, Saint Louis, Missouri, USA.

Soft palate (SP) reconstruction remains a challenge for the head and neck reconstructive surgeon. One favorable local flap option is the longus capitis muscle (LCM), a deep neck flexor with redundant muscle function, appropriate bulk, and a relatively straightforward surgical harvest. A retrospective review of 3 patients with T2 to T4 tonsil squamous cell carcinoma requiring SP resection and LCM reconstruction at a single institution was performed. Read More

World Neurosurg 2019 Aug 8;128:501-505. Epub 2019 May 8.

Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background: Chiari malformation results from a bony structural anomaly of the skull base. The structural defect causes downward displacement of the cerebellar tonsils through the foramen magnum. The herniated tonsils block the normal flow of cerebrospinal fluid, which causes a wide spectrum of clinical symptoms. Read More

J Oral Pathol Med 2019 Jul 22;48(6):483-490. Epub 2019 May 22.

Oral & Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, SAR China.

Background: Oral squamous cell carcinoma (SCC) is a lethal and deforming disease of rising incidence and global significance; 600 000 new cases are seen each year, including 40 000 in China. Despite advances in management, 50% of patients die within 5 years of diagnosis. Cancer is the leading cause of death in Hong Kong, with the Hong Kong Cancer Registry (HKCR) confirming a 2% increase in new cases each year, and oral SCC the tenth leading cause of cancer death in males. Read More