6,154 results match your criteria Malignant Tumors of the Temporal Bone

The impact of industrialization on malignant neoplastic disease of bone in England: A study of medieval and industrial samples.

Int J Paleopathol 2022 Jun 23;38:32-40. Epub 2022 Jun 23.

Forensic and Archaeological Sciences, University of Bradford, Bradford BD7 1DP, UK. Electronic address:

Objective: The increasing prevalence of malignant disease has been associated with shifts in environmental, socioeconomic, and lifestyle risk factors as well as increased adult lifespan. We examine the relationship between malignant neoplasms affecting bone, age and industrialization.

Materials: Pre-existing skeletal data from 11 medieval (1066-1547, n = 8973) and 14 industrial (1700-1890, n = 4748) cemeteries (N = 13,721) from England. Read More

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Hyperostosis in orbital rhabdomyosarcoma.

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Department of Ophthalmology and Visual Sciences, Philippine General Hospital, Manila, Philippines.

Rhabdomyosarcoma is the most common soft-tissue sarcoma in paediatric patients and may arise as a primary orbital neoplasm. Imaging studies show a unilateral solitary orbital lesion. With larger tumours, erosion of the adjacent orbital walls is a common accompanying bony change. Read More

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Anti-SARS-CoV2 antibody-mediated cytokine release syndrome in a patient with acute promyelocytic leukemia.

BMC Infect Dis 2022 Jun 13;22(1):537. Epub 2022 Jun 13.

Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität and Humboldt Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.

Background: Passive immunization against SARS-CoV-2 limits viral burden and death from COVID-19; however, it poses a theoretical risk of disease exacerbation through antibody-dependent enhancement (ADE). ADE after anti-SARS-CoV2 antibody treatment has not been reported, and therefore the potential risk and promoting factors remain unknown.

Case Presentation: A 75-year-old female was admitted to the emergency room with recurrent, unexplained bruises and leukocytopenia, anemia, and thrombocytopenia. Read More

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Infra-Temporal and Pterygo-Palatine Fossae Tumors: A Frontier in Endoscopic Endonasal Surgery-Description of the Surgical Anatomy of the Approach and Report of Illustrative Cases.

Int J Environ Res Public Health 2022 May 25;19(11). Epub 2022 May 25.

Programma Neurochirurgia Ipofisi-Pituitary Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.

Infratemporal and pterygopalatine fossae (ITF and PPF) represent two complex paramedian skull base areas, which can be defined as jewelry boxes, containing a large number of neurovascular and osteomuscular structures of primary importance. They are in close communication with many craniofacial areas, such as nasal/paranasal sinuses, orbit, middle cranial fossa, and oral cavities. Therefore, they can be involved by tumoral, infective or inflammatory lesions spreading from these spaces. Read More

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[The Anterior Transpetrosal Approach].

No Shinkei Geka 2022 May;50(3):614-624

Department of Neurosurgery, Keio University School of Medicine.

The Anterior transpetrosal approach is a skull base surgical procedure that can provide a wide operative view of the petroclival and the prepontine region. This approach requires one to accurately understand the anatomy of the anterior part of the temporal bone and the histological structure of the dura mater. In addition, it is necessary to learn operative techniques for venous preservation, accurate hemostasis at each step, and prevention of cerebrospinal fluid leakage. Read More

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[History of Skull Base Surgery].

Akio Morita

No Shinkei Geka 2022 May;50(3):496-507

Department of Neurological Surgery, Nippon Medical School.

Skull base surgery is a surgical field that involves the cooperation of multiple surgical and medical specialties, including neurosurgery, head-neck surgery, plastic-reconstructive surgery, radiation oncology, as well as multiple medical supporting teams. This field has been developed with the collaborative efforts of these medical specialties, and its history can be divided into five phases: Beginning of surgery(Prior to 1940); Early skull base surgery driven by the ENT-HN surgery group(1940-70); Conventional skull base surgery development based on anatomical, physiological knowledge and microsurgical equipment and technique(1970-90); Reflection and consolidation of the surgical dimension(1995-2005); and Evolution of endoscopic and new skull base surgical techniques(2005-). Several topics and advancements have improved this surgical field, such as access to the cavernous sinus, petrosal-temporal bone, and foramen magnum; concepts of minimally invasive surgical techniques; advanced endoscopic instruments; knowledge of biological assessments; and development of surgical robotics. Read More

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Giant Cell Tumour Of The Occipital Bone In A 13-Year Old Male.

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):378-380

3Department of Radiology, Mayo Clinic, Florida, USA.

Giant Cell Tumours (GCT) are usually found at the extremities of the long bones and their presence in the skull being less than 1%. In the skull, sphenoidal bone and temporal bone are the commonest sites. There have been very few reports of GCTs of the occipital bone. Read More

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Temporal Bone Squamous Cell Carcinoma: Molecular Markers Involved in Carcinogenesis, Behavior, and Prognosis: A Systematic Review.

Int J Mol Sci 2022 Apr 20;23(9). Epub 2022 Apr 20.

Department of Neuroscience-DNS, Otolaryngology Section, University of Padova, 35128 Padova, Italy.

Temporal bone squamous cell carcinoma (TBSCC) is an uncommon malignancy with a poor prognosis in advanced cases. The dismal outcome of advanced TBSSC cases is largely due to the cancer's local aggressiveness and the complex anatomy of this region, as well as to persistent pitfalls in diagnosis and treatment. Molecular changes occur in malignancies before any morphological changes become visible, and are responsible for the disease's clinical behavior. Read More

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Skull Base Tumor Mimics.

Neuroimaging Clin N Am 2022 May;32(2):327-344

Department of Radiology, NYU Langone Health, 222 East 41st Street, 5th Floor Radiology, New York, NY 10017, USA. Electronic address:

Many different benign and malignant processes affect the central skull base and petrous apices. Clinical evaluation and tissue sampling are difficult because of its deep location, leaving imaging assessment the primary means for lesion evaluation. Skull base lesions demonstrate a variety of confusing appearances on imaging, creating diagnostic dilemmas. Read More

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Posterior-Anterior Cephalometric Study of Neurofibromatosis Type 1 Patients With Facial Plexiform Neurofibroma: Analysis of Skeletal Symmetry Concerning Midfacial and Skull Base Reference Points (Zygomatic Arch, Mastoid, and Juga).

Anticancer Res 2022 May;42(5):2607-2623

Department of Orthodontics, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.

Background/aim: Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome that is also characterized by skeletal abnormalities. In the cranial region, skeletal dysplasia is observed that is associated with a characteristic peripheral nerve sheath tumor, the plexiform neurofibroma (PNF). The aim of the study was to determine PNF-associated skeletal asymmetries of the mid-skull and skull base as an indicator of local tumor development. Read More

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Osteomas of temporal bone: a rare presentation.

BMJ Case Rep 2022 Apr 22;15(4). Epub 2022 Apr 22.

ENT, Head and Neck Surgery, Sri Ramachandra University Medical College, Chennai, India.

Osteoma of the temporal bone is an unusual benign slow-growing tumour composed of mature lamellar bone. It is a single pedunculated mass that often occurs unilaterally. Osteomas of external auditory canal are more common than in the other parts of temporal bone. Read More

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Simultaneous monitoring of disease and microbe dynamics through plasma DNA sequencing in pediatric patients with acute lymphoblastic leukemia.

Sci Adv 2022 04 20;8(16):eabj1360. Epub 2022 Apr 20.

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94304, USA.

Treatment of acute lymphoblastic leukemia (ALL) necessitates continuous risk assessment of leukemic disease burden and infections that arise in the setting of immunosuppression. This study was performed to assess the feasibility of a hybrid capture next-generation sequencing panel to longitudinally measure molecular leukemic disease clearance and microbial species abundance in 20 pediatric patients with ALL throughout induction chemotherapy. This proof of concept helps establish a technical and conceptual framework that we anticipate will be expanded and applied to additional patients with leukemia, as well as extended to additional cancer types. Read More

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[Endoscopic transnasal approach in surgical treatment of petrous temporal bone cholesteatoma extending towards the clivus. Three clinical observations and literature review].

Zh Vopr Neirokhir Im N N Burdenko 2022 ;86(2):97-102

Burdenko Neurosurgical Center, Moscow, Russia.

Petrous temporal bone Cholesteatoma is widely described in the literature and accounts for up to 9% of all neoplasms of this localization. These cholesteatomas rarely spread towards the clivus. Isolated clival cholesteatomas are described only as single cases. Read More

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Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumours of the Ear.

Ann Sandison

Head Neck Pathol 2022 Mar 9;16(1):76-86. Epub 2022 Apr 9.

Guy's & St Thomas' NHS Foundation Trust, King's College London, London, UK.

In the recently published 5th Edition of the World Health Organisation Classification of Head and Neck Tumours, there are relatively few changes to report in terms of nomenclature in lesions of ear and temporal bone and fewer developments in molecular pathogenesis in comparison to other sites, particularly in sinonasal tract. Ear and temporal bone tumours are rare and biopsy material is limited. As a result, resources in the literature are scarce with few large series, no controlled clinical trials and the approaches to staging and management are not standardised. Read More

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Lutetium-177 Dotatate-Induced Hemolytic Anemia and Myelodysplastic Syndrome.

Cureus 2022 Feb 19;14(2):e22392. Epub 2022 Feb 19.

Pediatrics, Woodhull Medical Center, New York, USA.

Lutetium-177 (Lu) dotatate is a type of peptide receptor radioligand therapy (PRRT) using radiolabeled somatostatin for patients with progressive somatostatin receptor-positive gastrointestinal neuroendocrine tumors. While cases of therapy-related myeloid neoplasms (t-MN) have been described as a consequence of Lu dotatate, there are no reports of hemolytic anemia associated with therapy. We present a case of a 68-year-old woman with metastatic low-grade neuroendocrine tumor who presented four weeks after the second dose of Lu dotatate with progressive fatigue and dyspnea. Read More

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February 2022

Metastatic cancer along ancient Silk Road: A possible case from Xinjiang (China).

Int J Paleopathol 2022 06 30;37:23-29. Epub 2022 Mar 30.

School of Ethnology and Sociology, Minzu University of China, Beijing 100081, China. Electronic address:

Objective: Palaeopathological evidence of cancer, especially metastatic cancer, is rare in China. This paper describes and diagnoses a cranium with multiple lytic lesions recovered from the Sampula cemetery in Xinjiang, attempting to diagnose the type of disease that could have caused the pathological lesions observed.

Material: A cranium from an adult male (#00106) was recovered from the Sampula cemetery (dated to 55 BCE to 335 CE) located in the Luopu County, the Hotan River oasis on the southern edge of the Tarim Basin in southern Xinjiang. Read More

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Letter to the Editor Regarding "Functional Prognosis Following Temporal Bone Chondroblastoma Resection: A Systematic Review and Case Illustration".

Keyi Guo Yufei Li

World Neurosurg 2022 Apr;160:118

School of Medicine and Department of Surgery, School of Medicine, Hunan Normal University, Changsha, Hunan, China. Electronic address:

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A Mass in the Infratemporal Fossa.

JAMA Otolaryngol Head Neck Surg 2022 05;148(5):484-485

Department of Otolaryngology-Head & Neck Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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Human vestibular schwannoma reduces density of auditory nerve fibers in the osseous spiral lamina.

Hear Res 2022 05 7;418:108458. Epub 2022 Feb 7.

Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, MA, USA; Eaton Peabody Laboratories and Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA; Department of Otolaryngology, Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

Hearing loss in patients with vestibular schwannoma (VS) is commonly attributed to mechanical compression of the auditory nerve, though recent studies suggest that this retrocochlear pathology may be augmented by cochlear damage. Although VS-associated loss of inner hair cells, outer hair cells, and spiral ganglion cells has been reported, it is unclear to what extent auditory-nerve peripheral axons are damaged in VS patients. Understanding the degree of damage VSs cause to auditory nerve fibers (ANFs) is important for accurately modeling clinical outcomes of cochlear implantation, which is a therapeutic option to rehabilitate hearing in VS-affected ears. Read More

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Thyroid eye disease with concurrent orbital lymphoma: a radiological surprise.

Endocrinol Diabetes Metab Case Rep 2022 Mar 1;2022. Epub 2022 Mar 1.

Department of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Summary: Thyroid eye disease (TED) is the most common extra-thyroidal manifestation in Graves' disease (GD). Additional/concurrent/synchronous pathologies may be present, especially in elderly patients who present with atypical features such as non-axial (or eccentric) proptosis, absence of lid lag and restricted superior extra-ocular movements. A 70-year-old female presented with progressive proptosis of her left eye and diplopia. Read More

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3-T magnetic resonance-guided high-intensity focused ultrasound (3 T-MR-HIFU) for the treatment of pain from bone metastases of solid tumors.

Support Care Cancer 2022 Jul 24;30(7):5737-5745. Epub 2022 Mar 24.

Osteoncology and Rare Tumors Center (CDO-TR), IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST ) "Dino Amadori", Via P. Maroncelli 40, 47014, Meldola, Italy.

Introduction: Bone metastases (BM) are still the main cause of morbidity and mortality in cancer patients, not only because of their complications, defined as skeletal-related events (SREs), but also because of the negative impact bone pain has on quality of life (QoL) and survival, especially when opioid analgesics and locoregional treatments fail.

Materials And Methods: A single-center prospective study was carried out on 12 patients with symptomatic BM treated with MRI-guided focused ultrasound (MR-HIFU). The primary endpoint was the effectiveness of MR-HIFU in reducing current and breakthrough cancer pain (BTCP) scores. Read More

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Temporal changes in incidence of relapse and outcome after relapse of childhood acute lymphoblastic leukemia over three decades; a Nordic population-based cohort study.

Leukemia 2022 05 21;36(5):1274-1282. Epub 2022 Mar 21.

Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.

Relapse remains the main obstacle to curing childhood acute lymphoblastic leukemia (ALL). The aims of this study were to compare incidence of relapse, prognostic factors, and survival after relapse between three consecutive Nordic Society of Pediatric Hematology and Oncology trials. Relapse occurred as a primary event in 638 of 4 458 children (1. Read More

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Anterior Petrosal Approach to Petrous Apex Meningioma: Climbing the Rock-Two-Dimensional Operative Video.

World Neurosurg 2022 Jun 18;162:67. Epub 2022 Mar 18.

Department of Neurosurgery and Skull Base Surgery, Hospital Ernesto Dornelles, Porto Alegre, Brazil.

A 47-year-old woman was referred to the neurological surgery department after a self-limiting episode of dizziness and headache. Magnetic resonance imaging showed an extra-axial mass in the right petrous apex, suggesting a meningioma. We chose the anterior petrosal approach (APA) because meningioma is a benign tumor with brainstem compression, and our goal was total removal for potential cure of the disease. Read More

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The first case of myxoinflammatory fibroblastic sarcoma affecting the maxillary bone.

Int J Health Sci (Qassim) 2022 Mar-Apr;16(2):37-39

Department of Pathology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.

Myxoinflammatory fibroblastic sarcoma (MIFS) is rare and malignant soft-tissue neoplasms that typically present in the extremities. In the literature, MIFS has been reported in the groin, back, neck, nose, and temporal regions in addition to the extremities. We report a case of MIFS presenting with the complaints of nasal bleeding, purulent nasal discharge, and swelling on the right side of his face. Read More

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Paragangliomas da Cabeça e Pescoço: A Experiência de um Centro Oncológico do Sul da Europa.

Acta Med Port 2022 Mar 15. Epub 2022 Mar 15.

Serviço de Otorrinolaringologia. Instituto Português de Oncologia Francisco Gentil. Lisboa. Portugal.

Introduction: Paragangliomas are usually benign slow-growing tumors, but they are locally invasive and can cause significant morbidity. The aim of this study was to characterize the presenting symptoms, secretory status, genetics, imaging features, treatment modalities, post-treatment complications and survival of patients with head and neck paragangliomas treated at a single institution.

Material And Methods: We retrospectively reviewed the clinical records of patients managed at our center between 1997 and 2020. Read More

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Assessing the Prognostic Value of the ChOLE Classification in Predicting the Severity of Acquired Cholesteatoma.

Otol Neurotol 2022 04;43(4):472-480

Department of Otorhinolaryngology, Amsterdam UMC, location Academic Medical Center, University of Amsterdam, The Netherlands.

Objective: To assess the prognostic value of the ChOLE classification in predicting the severity of acquired cholesteatoma.

Method: A retrospective chart review of patients undergoing primary cholesteatoma surgery in our tertiary referral center. The primary outcome measures were analyzed in three groups of follow up (FU): residual cholesteatoma in group A, FU > 52 weeks after last-look surgery or MRI-DWI; recurrent cholesteatoma in group B, FU > 52 weeks after last outpatient visit; and adverse events (AE) in group C, FU > 12 weeks after surgery. Read More

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Gliosarcoma with osteosarcomatous component: A case report and short review illustration.

Pathol Res Pract 2022 Apr 7;232:153837. Epub 2022 Mar 7.

Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address:

Background: Gliosarcoma (GS) represents a rare variant of glioblastoma in the central nervous system, characterized by biphasic histopathological features of gliomatous and sarcomatous components. Here, we present an unusual case of GS, which also demonstrated osteosarcomatous differentiation.

Case Presentation: A 65-year-old female patient underwent gross total resection (GTR) of the right temporal lobe lesion. Read More

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A 41-Year-Old Woman with a Late Cerebral Metastasis 16 Years After an Initial Diagnosis of Cutaneous Melanoma.

Am J Case Rep 2022 Mar 8;23:e935728. Epub 2022 Mar 8.

Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China (mainland).

BACKGROUND Late cerebral metastasis more than 10 years after the diagnosis of cutaneous melanoma is very rare. This report is of a woman with late cerebral metastasis 16 years after an initial diagnosis of cutaneous melanoma. CASE REPORT A 41-year-old woman had been diagnosed with malignant melanoma 16 years prior from a biopsy of a dish-pattern tumor on the back, for which she received chemotherapy for 5 times (therapeutic regimen and medications were not available). Read More

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Unusual mimicker of odontogenic carcinoma: Primary synovial sarcoma of the temporomandibular joint- a critical role for molecular diagnosis.

Pathol Res Pract 2022 Apr 25;232:153824. Epub 2022 Feb 25.

Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

Background: Synovial sarcomas (SS) are malignant tumors originating from pluripotent mesenchymal cells, with predilection for periarticular areas, as deep-seated soft tissue tumors. Treatment of SS of the head and neck (HN) is usually radical local excision and additional radiation or (neo)adjuvant chemotherapy or both. SS are characterized by a specific SS18-SSX1/2/4 fusion gene. Read More

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