5,794 results match your criteria Malignant Tumors of the Temporal Bone


Middle ear adenomatous neuroendocrine tumors: suggestion for surgical strategy.

Braz J Otorhinolaryngol 2020 Jun 15. Epub 2020 Jun 15.

The Second Affiliated Hospital of Nanchang University, Department of Otolaryngology Head and Neck Surgery, Nanchang, China; Jiangxi Biomedical Engineering Research Center for Auditory Research, Nanchang, China. Electronic address:

Introduction: Middle ear adenomatous neuroendocrine tumors are extremely rare neoplasms with epithelial and neuroendocrine differentiation, accounting for fewer than 2% of all middle and inner ear tumors. Universal standard surgical procedures for different stages of these tumors remain elusive due to the limitation of the small number of case reports or investigations.

Objective(s): This study intends to investigate proper surgical strategies for patients with middle ear adenomatous neuroendocrine tumors. Read More

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http://dx.doi.org/10.1016/j.bjorl.2020.05.011DOI Listing

Tentorial Peeling: Surgical Extradural Navigation to Protect the Temporal Lobe in the Focused Combined Transpetrosal Approach.

Oper Neurosurg (Hagerstown) 2020 Jun 15. Epub 2020 Jun 15.

Skull Base Surgery Center, Baylor University Medical Center, Dallas, Texas.

Background: Transpetrosal approaches have been used for treatment of tumors in the petroclival region for many years. Injury to the temporal lobe, however, has been a potential drawback of the techniques described to date.

Objective: To describe modifications of the transpetrosal surgical technique, which allows extradural manipulation of the temporal lobe during the focused combined transpetrosal approach. Read More

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http://dx.doi.org/10.1093/ons/opaa162DOI Listing

Increasing incidence of cancer and stage migration towards advanced disease in children and young adolescents in the Netherlands, 1990-2017.

Eur J Cancer 2020 Jul 7;134:115-126. Epub 2020 Jun 7.

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands; Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands. Electronic address:

Background: This is the first national study on trends in cancer incidence for children and young adolescents in the Netherlands, including stage at diagnosis as a potential marker of early diagnosis and better staging.

Methods: All neoplasms in patients younger than 18 years, diagnosed between 1990 and 2017 (N = 15,233), were derived from the Netherlands Cancer Registry. Incidence rates and the average annual percentage change with 95% CIs were calculated for all cancers combined and diagnostic (sub)groups. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.04.011DOI Listing

[Surgical treatment of epilepsy in children with gloneuronal brain tumors: morphology, MRI semiology and factors affecting the outcome].

Zh Vopr Neirokhir Im N N Burdenko 2020 ;84(1):6-22

Burdenko Neurosurgical Center, Moscow, Russia.

Introduction: Glioneuronal tumors (GNT) are usually found in children (less than 1.5% of all neoplasms of the brain). With rare exceptions, they are benign and usually manifest only by epilepsy, which is quite often resistant to treatment with AE drugs. Read More

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http://dx.doi.org/10.17116/neiro2020840116DOI Listing
January 2020

Temporal subtraction of low-dose and relatively thick-slice CT images with large deformation diffeomorphic metric mapping and adaptive voxel matching for detection of bone metastases: A STARD-compliant article.

Medicine (Baltimore) 2020 Mar;99(12):e19538

Department of Diagnostic Radiology and Nuclear Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu City, Shizuoka, Japan.

To evaluate the improvement of radiologist performance in detecting bone metastases at follow up low-dose computed tomography (CT) by using a temporal subtraction (TS) technique based on an advanced nonrigid image registration algorithm.Twelve patients with bone metastases (males, 5; females, 7; mean age, 64.8 ± 7. Read More

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http://dx.doi.org/10.1097/MD.0000000000019538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220493PMC

Chondromyxoid fibroma of the temporal bone: A rare case report.

Medicine (Baltimore) 2020 Mar;99(11):e19487

Department of Otorhinolaryngology, Beijing Tongren Hospital.

Rationale: Chondromyxoid fibroma (CMF) is a rare form of benign bone tumor and easily misdiagnosed as fibrosarcoma. Hence, to explore the clinical manifestations, diagnostic tests, and therapeutic procedures for temporal bone cartilage myxoid fibroma, it is important to optimize patient treatment and avoid overtreatment. Previous research has discussed cases of CMF, but this paper presents a systematic, complete, and comprehensive introduction of this disease based on this case and related literature. Read More

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http://dx.doi.org/10.1097/MD.0000000000019487DOI Listing
March 2020
5.723 Impact Factor

Clinical response to pazopanib in a patient with endolymphatic sac tumor not associated with von Hippel-Lindau syndrome.

CNS Oncol 2020 Mar 6;9(1):CNS50. Epub 2020 Mar 6.

Division of Molecular Pathology, Department of Pathology, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.

Endolymphatic sac tumors (ELSTs) are rare, locally invasive, vascular tumors of the temporal bone. These lesions are associated with von Hippel-Lindau syndrome but may arise sporadically. Early surgical intervention is recommended to prevent permanent neurologic deficits; however, many ELSTs are unresectable or are subtotally resected due to neurovascular compromise. Read More

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http://dx.doi.org/10.2217/cns-2019-0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163403PMC

Primary Paraganglioma of the Facial Canal: An Evidence-Based Approach.

Otolaryngol Head Neck Surg 2020 Apr 25;162(4):458-468. Epub 2020 Feb 25.

Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois, USA.

Objectives: To perform an evidence-based review evaluating presenting symptoms, imaging, and management for primary paragangliomas of the facial canal (PPFCs).

Data Sources: PubMed/MEDLINE, Embase, Cochrane Library, and Web of Science.

Review Methods: Studies were assessed for quality of evidence and bias with the Cochrane bias tool, GRADE, and MINORS criteria. Read More

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http://dx.doi.org/10.1177/0194599820907303DOI Listing

Clinical features and treatment of endolymphatic sac tumor.

Acta Otolaryngol 2020 Jun 18;140(6):433-437. Epub 2020 Feb 18.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Endolymphatic sac tumor (ELST) is an extremely rare disease that does not have established clinical guidelines. To provide guidance for the diagnosis and management of ELSTs. We retrospectively reviewed the medical records of patients who were suspected to have a lesion in the location of endolymphatic sac. Read More

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http://dx.doi.org/10.1080/00016489.2020.1722855DOI Listing

Combining Rotation and V-Y Design for Lower Forehead and Temporal Region Reconstruction With Myocutaneous Frontal Flap: Our Experience on 27 Consecutive Cases.

Ann Plast Surg 2020 Feb 7. Epub 2020 Feb 7.

From the Plastic and Reconstructive Surgery Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.

Background: Because of direct sun exposure, lower forehead and temporal area are anatomical regions with frequently observed skin tumors. The resulting defects after oncological ablations are usually treated, especially in older patients, by split thickness skin grafting or A-to-T and O-to-T flaps if facing small defects. On specific sites that expose bone or periosteum as well as when a skin graft is best avoided for cosmetic reasons, alternative reconstructive procedures should be considered. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002256DOI Listing
February 2020
1.458 Impact Factor

Myeloid sarcoma on the temporal region before the onset of the acute myeloid leukemia: an extremely rare case report.

Oral Maxillofac Surg 2020 Jun 22;24(2):251-254. Epub 2020 Jan 22.

Department of Oral & Maxillofacial Surgery, Traumatology and Prosthesis, Faculty of Dentistry, University of São Paulo, Av Prof. Lineu Prestes 2227 Butantã, São Paulo, State of São Paulo, 05508-000, Brazil.

Purpose: Myeloid sarcoma (MS) is a rare malignant tumor that arises outside the bone marrow and usually occurs concomitantly or after the acute myeloid leukemia (AML). The aim of the present study is to report an extremely rare case of a patient with an MS arising in the maxillofacial region before the onset of AML to serve as a guide on how to conduct the initial assessment and diagnosis of similar cases.

Materials And Methods: A 29-year-old healthy man complained of a "swelling on the head," which was rapidly increasing. Read More

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http://dx.doi.org/10.1007/s10006-020-00833-yDOI Listing

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.

Nat Commun 2020 01 16;11(1):307. Epub 2020 Jan 16.

University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK.

Autophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to ageing. A decrease in autophagy is associated with increasing age, yet it is unknown if this is causal in the ageing process, and whether autophagy restoration can counteract these ageing effects. Here we demonstrate that systemic autophagy inhibition induces the premature acquisition of age-associated phenotypes and pathologies in mammals. Read More

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http://dx.doi.org/10.1038/s41467-019-14187-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965206PMC
January 2020

Tumors of the temporal bone.

Cas Lek Cesk 2019 ;158(6):248-252

Temporal bone tumors are rare entities. Histologically these pathologies represent heterogeneous group of diseases. The most common tumors of the temporal bone are vestibular schwannoma, tympanojugular paragangliomas and temporal bone carcinomas. Read More

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January 2020

[Primary Ewing's sarcoma of the temporal bone: a rare case].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Nov;33(11):1105-1108

Ewing's sarcoma is a malignant, round cell tumor arising from the bones and primarily affecting children and adolescent. Involvement of the skull bones is rarely reported, constituting 1%-6% of the total Ewing's sarcoma cases. We describe a 33 years old male patient having Ewing sarcoma of the mastoid and petrous parts of temporal bone, whose clinical presentation mimicked mastoiditis with facial nerve palsy. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.11.024DOI Listing
November 2019

Value of Routine Magnetic Resonance Imaging for the Preoperative Assessment of Cochlear Implant Candidates.

Cureus 2019 Dec 3;11(12):e6279. Epub 2019 Dec 3.

Otolaryngology, Neurotology and Skull Base Surgery, King Saud University, Riyadh, SAU.

Background The selection of an appropriate imaging technique for assessment before cochlear implantation is critical for precise diagnosis and management. While magnetic resonance imaging (MRI) is used for the diagnosis of several conditions, such as labyrinthitis ossificans, cochlear nerve deficiency, and neoplasms, high-resolution computed tomography (HRCT) provides excellent details of the temporal bone. However, it remains unclear whether routine MRI provides any additional benefits over HRCT. Read More

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http://dx.doi.org/10.7759/cureus.6279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939976PMC
December 2019

Giant Cell Tumour of Temporal Bone and Infratemporal Fossa: A Rare Case.

Head Neck Pathol 2020 Jun 28;14(2):503-506. Epub 2019 Nov 28.

Department of Pathology, GB Pant Hospital, New Delhi, India.

Giant cell tumours (GCT) of the bone are uncommon primary bone neoplasms that occur mainly in the epiphysis of long bones. GCT of the skull is rarely encountered, particularly of the temporal bone. We report a rare case of giant cell tumour of the squamous portion of the temporal bone extending to the infratemporal fossa in a 38-year old male. Read More

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http://dx.doi.org/10.1007/s12105-019-01105-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235106PMC

Transcanal Transpromontorial Approach to Lateral Skull Base: Maximal Area of Exposure and Surgical Extensions.

World Neurosurg 2020 Mar 26;135:e181-e186. Epub 2019 Nov 26.

Department of Otolaryngology Head and Neck Surgery, Inselspital University Hospital and University of Bern, Bern, Switzerland; Hearing Research Laboratory, ARTORG Center for Biomedical Engineering, University of Bern, Bern, Switzerland.

Objective: To determine the possible surgical extensions and maximal area of exposure (AOE) achievable through the transcanal transpromontorial approach (TTA) to the internal auditory canal (IAC) and cerebellopontine angle. We hypothesize a possible extension of indication for this minimally invasive approach to the lateral skull base.

Methods: In this experimental anatomic study, the expanded TTA was first carried out in 4 temporal bones to define the anatomic boundaries of the maximal exposure, from 2 perspectives, the middle ear and the porus of the IAC. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.11.102DOI Listing

Fibrous dysplasia mimicking a pediatric endolymphatic sac tumor.

Int J Pediatr Otorhinolaryngol 2020 Feb 19;129:109785. Epub 2019 Nov 19.

Department of Otolaryngology - Head & Neck Surgery, Division of Pediatric Otology & Hearing Program, Nationwide Children's Hospital, Columbus, OH, USA; Department of Otolaryngology - Head & Neck Surgery, Division of Otology, Neurotology & Cranial Base Surgery, The Ohio State University, Columbus, OH, USA. Electronic address:

A 15-year-old female presented for evaluation of progressive hearing loss over a year. Computed tomographic imaging revealed a 11 x 6 × 6 mm osseous lesion with 'groundglass' appearance within the left posterior petrous bone lateral to vestibular aqueduct suspicious for an endolymphatic sac tumor. Surgical excision revealed fibrous dysplasia on histological analysis. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.109785DOI Listing
February 2020

Evaluation of Lateral Temporal Bone Resection in Locally Advanced Tumours of the Parotid Gland.

Indian J Otolaryngol Head Neck Surg 2019 Nov 30;71(Suppl 2):1402-1407. Epub 2018 Aug 30.

1Department of Otorhinolaryngology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

This study evaluated the effects of lateral temporal bone resection (LTBR) on local tumour control in patients with locally advanced parotid gland tumours. The medical records of seven patients treated with radical parotidectomy combined with LTBR for locally advanced primary parotid tumour at the Otolaryngology Department of Dokuz Eylul University between January 1995 and December 2016 were retrospectively evaluated. Demographic variables, tumour characteristics, treatment properties, postoperative complications, follow-up durations and local, regional and distant recurrences were analysed. Read More

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http://dx.doi.org/10.1007/s12070-018-1483-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841771PMC
November 2019

CT and MRI features of calvarium and skull base osteosarcoma (CSBO).

Br J Radiol 2020 Jan 28;93(1105):20190653. Epub 2019 Nov 28.

Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Objective: This study aims to assess the CT and MRI features of calvarium and skull base osteosarcoma (CSBO).

Methods: The CT and MRI features and pathological characteristics of 12 cases of pathologically confirmed CSBO were analyzed retrospectively.

Results: 12 patients (age range 9-67 years; 3 male, 9 female) were included in the study. Read More

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http://dx.doi.org/10.1259/bjr.20190653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948075PMC
January 2020

Interaction of arsenic trioxide and etoposide in Ewing sarcoma cell lines.

Oncol Rep 2020 Jan 20;43(1):337-345. Epub 2019 Nov 20.

Department of Orthopaedic Surgery, Eberhard Karls University Tuebingen, D‑72076 Tuebingen, Germany.

Ewing sarcomas (ES) are highly malignant mesenchymal tumors, which most often occur in children and adolescents. The current treatment of choice comprises wide resection in combination with multimodal chemotherapy including etoposide (Eto). Due to the serious side effects associated with common chemotherapeutics and prevalent multidrug resistance in recurrent and metastatic ES, there is a growing demand for alternative strategies and add‑on drugs. Read More

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http://dx.doi.org/10.3892/or.2019.7409DOI Listing
January 2020

From the Occipital Condyle to the Sphenoid Sinus: Extradural Extension of the Far Lateral Transcondylar Approach with Endoscopic Assistance.

World Neurosurg 2020 Feb 14;134:e771-e782. Epub 2019 Nov 14.

Department of Neurosurgery, Lariboisière Hospital, Paris VII-Diderot University, Paris, France.

Background: Surgical management of extensive skull base tumors, such as chordoma and chondrosarcoma, remains very challenging. The need for gross total removal to improve survival must be weighed against the risk of injury to neurovascular structures and the loss of stability at the craniovertebral junction. In cases of tumors that are already compromising craniovertebral junction stability, the occipital condyle can be exploited as a deep keyhole to reach the clivus, petrous apex, and sphenoid sinus. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.10.190DOI Listing
February 2020

Trends of temporal bone cancer: SEER database.

Am J Otolaryngol 2020 Jan - Feb;41(1):102297. Epub 2019 Sep 12.

Drexel University College of Medicine, United States of America. Electronic address:

Objective: This retrospective review aims to analyze epidemiological trends related to temporal bone cancer, and primarily of the squamous cell subtype. Potential trends analyzed included age, gender, and geographical location.

Data Sources: This retrospective review analyzed data found in the National Cancer Institute's SEER Database for cases of carcinomas of the middle ear. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.102297DOI Listing

Primary carcinoid tumor in the external auditory canal.

J Pathol Transl Med 2020 Mar 13;54(2):184-187. Epub 2019 Nov 13.

Department of Pathology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

A 39-year-old man visited the department of otolaryngology due to an ongoing hearing disturbance that had lasted for 1 year. Temporal bone computed tomography revealed soft tissue density nearly obliterating the left external auditory canal (EAC). The mass was composed of sheets of round tumor cells containing moderate amounts of fine granular cytoplasm and salt and pepper chromatin. Read More

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http://dx.doi.org/10.4132/jptm.2019.11.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093287PMC

The endoscopic anatomy of the cochlear hook region and fustis: surgical implications.

Acta Otorhinolaryngol Ital 2019 Oct;39(5):353-357

Department of Otolaryngology Head and Neck Surgery, University Hospital of Modena, Italy.

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http://dx.doi.org/10.14639/0392-100X-2388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843579PMC
October 2019

Surgical Management of a Recurrent Odontogenic Keratocyst With Orbital and Temporal Fossa Invasion.

Ophthalmic Plast Reconstr Surg 2019 Nov/Dec;35(6):e151-e154

Orbital and Ophthalmic Plastic Surgery, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Wauwatosa, Wisconsin, U.S.A.

Odontogenic keratocyst is a benign locally aggressive odontogenic cyst with a high recurrence rate. This report presents an unusual case of a recurrent odontogenic keratocyst with zygomatic bone involvement and orbital and temporal extension resulting in globe compression. Odontogenic keratocyst is reviewed, and surgical management of the cyst is discussed. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001477DOI Listing
January 2020
1 Read

Superiority of intensity-modulated radiation therapy in nasopharyngeal carcinoma with skull-base invasion.

J Cancer Res Clin Oncol 2020 Feb 1;146(2):429-439. Epub 2019 Nov 1.

Department of Radiation Oncology, Affiliated Hospital of Guilin Medical University, 15 Lequn Road, Guilin, 541001, People's Republic of China.

Purpose: To compare the clinical results and functional outcomes between two-dimensional conventional radiation therapy (2DRT) and intensity-modulated radiation therapy (IMRT) in nasopharyngeal carcinoma (NPC) with skull-base invasion.

Methods: A total of 1258 patients were subclassified into two groups: mild skull-base invasion group (792; 63%) and severe skull-base invasion group (466; 37%). Patients were pair matched (1:1 ratio) using six clinical factors into 2DRT or IMRT groups. Read More

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http://dx.doi.org/10.1007/s00432-019-03067-yDOI Listing
February 2020

Primary Ewing's sarcoma of the temporal bone: a rare entity and review of the literature.

BMJ Case Rep 2019 Oct 23;12(10). Epub 2019 Oct 23.

Surgical Oncology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Ewing's sarcoma (ES) is the second most common malignant primary bone tumour in children and adolescents. It primarily affects the diaphysis of long bones and pelvis. ES arising from temporal bone is extremely rare. Read More

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http://dx.doi.org/10.1136/bcr-2019-230768DOI Listing
October 2019

Combined Endoscopic and Microscopic Surgery for Perilabyrinthine Lesions: Feasibility and Technique.

Otol Neurotol 2019 12;40(10):1306-1312

Department of Otorhinolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China.

Objectives: To determine the feasibility of endoscopic-assisted surgery for lesions involving the perilabyrinthine recesses, and develop and validate a technique for this kind of lesions that increases the possibility of preserving the labyrinth and cochlea.

Study Design: Observational study.

Setting: Referral center. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002399DOI Listing
December 2019
1.598 Impact Factor

Recidivism After Endoscopic Treatment of Cholesteatoma.

Otol Neurotol 2019 12;40(10):1313-1321

Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

Objective: To investigate the recidivism rate of cholesteatoma treated via endoscopic ear surgery (EES), either via transcanal endoscopic ear surgery or endoscopic assisted tympanomastoidectomy compared with a microscopic postauricular approach.

Study Design: Retrospective chart review.

Setting: Academic otology practice. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002395DOI Listing
December 2019
1 Read

Biochemical Recurrence in Prostate Cancer and Temporal Association to Bone Metastasis.

Am J Case Rep 2019 Oct 16;20:1521-1525. Epub 2019 Oct 16.

Department of Pathology, University of Cincinnati, Cincinnati, OH, USA.

BACKGROUND Prostate cancer is a common cancer in men. Radical prostatectomy, i.e. Read More

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http://dx.doi.org/10.12659/AJCR.918569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818640PMC
October 2019
1 Read

"Endolymphatic sac tumour": A case report with review of literature.

Indian J Pathol Microbiol 2019 Oct-Dec;62(4):608-610

Department of Neurosurgery, Xcellent Care Hospital, Chennai, Tamil Nadu, India.

Endolymphatic sac tumour (ELST) is a non-metastasizing low grade adenocarcinoma of endolymphatic sac origin. It is also known as Heffner tumour, low grade adenocarcinoma of endolymphatic sac origin and aggressive papillary middle ear tumour. These tumours are closely associated with Von Hippel Lindau (VHL) disease. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_345_18DOI Listing
February 2020
1 Read

Ewing sarcoma with myxoid stroma: Case report of an unusual histological variant.

Pathol Res Pract 2019 Dec 24;215(12):152665. Epub 2019 Sep 24.

Department of Pathology, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, 251 East Huron St, Feinberg 7-342A, Chicago, IL 60611, United States.

We describe the case of a Ewing sarcoma with prominent myxoid stroma of the temporal bone in a 26-year-old female. Histologically, the tumor exhibited a fascicular growth pattern of round to spindled cells with a minimal amount of pale eosinophilic to clear cytoplasm and oval or spindled nuclei with finely dispersed chromatin and small nucleoli. Myxoid changes were prominent (>50%), with reticular or pseudoacinar growth of the loosely cohesive cells. Read More

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http://dx.doi.org/10.1016/j.prp.2019.152665DOI Listing
December 2019

Renal Medullary Carcinoma With Metastasis to the Temporal Fossa and Orbit.

Ophthalmic Plast Reconstr Surg 2019 Nov/Dec;35(6):e149-e151

Department of Ophthalmology, Columbia University Medical Center.

A 22-year-old Hispanic man with sickle cell trait presented with blurred vision, double vision, and pain with OD movement. MRI demonstrated an extra-axial mass centered around the temporal bone with extension into the middle cranial fossa and lateral aspect of the extra-conal right orbit, and mass effect on the lateral rectus muscle. Biopsy of the lesion was consistent with renal medullary carcinoma. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001478DOI Listing
January 2020
1 Read
0.914 Impact Factor

[Giant cell reparative granuloma of the temporal bone: A case report].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Aug;44(8):935-940

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Giant cell reparative granuloma (GCRG) is a type of non-neoplastic lesion that can be rarely found in clinical practices. Due to the lack of specificity in symptoms, signs and auxiliary examinations, it is likely to be misdiagnosed, and thereby affecting the treatment and prognosis. In July 2018, a GCRG patient who was described with "4 years of hearing loss in the left ear, accompanied by 2 months of preauricular swelling" as the first symptom was admitted in our hospital. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2019.190055DOI Listing
August 2019
1 Read

A patient with conventional and follicular variant papillary thyroid microcarcinoma and Eagle's syndrome, Langlais type III, with hyoid bone variation.

Ann Ital Chir 2019 09 19;90. Epub 2019 Sep 19.

Aim: Presenting an extraordinary case of Eagle's syndrome (ES) with the classical and follicular variant of papillary thyroid microcarcinoma (PTmC) and an uncommon stylohyoid ligament calsification, aside from O'Carroll's System.

Case Report: A 52-year-old Turkish man with an histopathology of the follicular variant of PTmC (FVPTmC) of his right lobe and conventional PTmC of his left lobe of the thyroid with an adjuvant 100 mCi radioactive iodine (RAI) ablation was admitted. On the routine follow-up of the present case, a lineer structure at the 3rd compartment of neck in his ultrasonography, a styloid ligament calsification in his noncontrast computed tomography (CT), and a left styloid process of the temporal bone of 29 mm in size in his three-dimensional (3D) CT scanning had been revealed. Read More

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September 2019
2 Reads

Intraorbital, Infratemporal And Intracranial Extensions As The First Presentation Of Follicular Thyroid Carcinoma.

J Ayub Med Coll Abbottabad 2019 Jul-Sep;31(3):461-463

Department of Otorhinolaryngology, Khyber Teaching Hospital, Peshawar, Pakistan.

Metastatic skull deposits from follicular thyroid carcinoma are rare, and let alone this being the primary presenting symptom with no history of thyroid cancer is exceptionally rarer. A 40-yearold female patient presented with a mass in the temporal and occipital region of the skull. Fine needle aspiration cytology confirmed multiple fragments of a neoplasm composed of variably sized follicles lined by tumour cells having pleomorphic hyperchromatic nuclei. Read More

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December 2019
2 Reads

[A rare pathology of the petrous part of the temporal bone: adenoma of the middle ear].

HNO 2020 Jan;68(1):55-58

Klinik für Hals‑, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Medizinische Fakultät OWL, Klinikum Bielefeld, Universität Bielefeld, Teutoburger Str. 50, 33604, Bielefeld, Deutschland.

Adenomas are very rare tumors of the middle ear. They are benign neoplasms originating from the glandular components of the mucous membrane of the middle ear. The middle ear adenoma was first described by Hyams and Michaels in 1976, which was named an adenomatous tumor. Read More

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http://dx.doi.org/10.1007/s00106-019-00753-8DOI Listing
January 2020
1 Read

Bone Marrow and Tumor Radiomics at F-FDG PET/CT: Impact on Outcome Prediction in Non-Small Cell Lung Cancer.

Radiology 2019 11 17;293(2):451-459. Epub 2019 Sep 17.

From the Department of Radiology, James H. Clark Center (S.A.M., A.N.C.L., S.N., V.S.N.), Division of Nuclear Medicine, Department of Radiology (G.A.D.), and Division of Thoracic Surgery, Department of Cardiothoracic Surgery (J.B., J.B.S.), Stanford University, 318 Campus Dr, Room S355, Stanford, CA 94305; Palo Alto VA Health Care System, Palo Alto, Calif (M.V.); California Pacific Medical Center, San Francisco, Calif (G.H.); and Section of Pulmonary & Critical Care Medicine, Moffitt Cancer Center & Research Institute; Morsani College of Medicine, University of South Florida, Tampa, Fla (V.S.N.).

Background Primary tumor maximum standardized uptake value is a prognostic marker for non-small cell lung cancer. In the setting of malignancy, bone marrow activity from fluorine 18-fluorodeoxyglucose (FDG) PET may be informative for clinical risk stratification. Purpose To determine whether integrating FDG PET radiomic features of the primary tumor, tumor penumbra, and bone marrow identifies lung cancer disease-free survival more accurately than clinical features alone. Read More

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http://dx.doi.org/10.1148/radiol.2019190357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822770PMC
November 2019
1 Read

Anterolateral thigh free flap in reconstruction of lateral skull base defects after oncological resection.

Eur Arch Otorhinolaryngol 2019 Dec 12;276(12):3487-3494. Epub 2019 Sep 12.

Department of Otolaryngology and Laryngological Oncology, Medical University of Lublin, Jaczewskiego 8, 20 954, Lublin, Poland.

Purpose: Evaluation of the utility of the free anterolateral thigh flap reconstruction of the defects resulting from radical temporal bone resection in the management of lateral skull base malignancies in a single institution.

Methods: An analysis of 17 en bloc subtotal petrosectomies for removal of malignant tumours was performed. There were 12 squamous cell carcinomas, 4 basal cell carcinomas and 1 adenoid cystic carcinoma. Read More

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http://dx.doi.org/10.1007/s00405-019-05627-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858904PMC
December 2019
3 Reads

Intracranial Malignant Nerve Sheath Tumor in the Middle Cranial Fossa: A Rare Case Report with Review of Literature.

Asian J Neurosurg 2019 Jul-Sep;14(3):922-926

Department of Neurosurgery, Neurosurgical Hospital, Vadodara, Gujarat, India.

Intracranial malignant nerve sheath tumors rarely arise in the central nervous system. They usually arise from the cranial nerves, though rare cases of intraparenchymal lesions have also been reported. We report a case of malignant nerve sheath tumor located in the right middle cranial fossa. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_59_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703013PMC
September 2019
1 Read

Real-Time and 3D Quantification of Cancer Cell Dynamics: Exploiting a Bioengineered Human Bone Metastatic Microtissue.

Methods Mol Biol 2019 ;2054:59-77

Faculty of Health, School of Biomedical Sciences, Australian Prostate Cancer Research Centre (APCRC-Q), Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, QLD, Australia.

The study of dynamic processes in the bone metastatic compartment has been challenged by the restrictive access and limited live imaging capabilities that in vivo bone models provide. In this protocol, we show the use of a human bone metastatic bioengineered microtissue for the quantitative investigation of cancer cells in an in vitro bone-like microenvironment. Using live cell epifluorescence microscopy, traditional- and spinning disc-confocal laser scanning microscopy, we demonstrate how to obtain multidimensional real-time data of fluorescently labeled cancer cells in the metastatic microenvironment. Read More

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http://dx.doi.org/10.1007/978-1-4939-9769-5_3DOI Listing

Intraosseous Petrous Apex Schwannoma: Case Report and Review of Literature.

World Neurosurg 2019 Dec 30;132:182-187. Epub 2019 Aug 30.

Department of Neurosurgery, NYU Langone Health, New York, New York, USA.

Background: Intraosseous petrous apex schwannomas are an exceedingly rare entity; little is known about their epidemiology, natural history, and postoperative outcomes.

Case Description: Here, we present the fourth known case of a primary intraosseous schwannoma of the petrous apex: a 68-year-old woman presenting with diplopia, facial numbness, progressive intermittent vertigo, tinnitus, diminished hearing, and ataxia. She underwent a transtemporal approach for subtotal resection of the tumor with subsequent stereotactic radiosurgery. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.08.157DOI Listing
December 2019

A rare case of primary inverted papilloma of the middle ear.

Pan Afr Med J 2019 22;33:49. Epub 2019 May 22.

Department of Otolaryngology-Head and Neck Surgery, Tahar Sfar Hospital, Mahdia, Tunisia.

Inverted papilloma (IP) of the middle ear as a primary lesion or as an extension of a sinonasal papilloma, is extremely rare. Only 23 cases of primary inverted papilloma of the middle ear have been reported in the literature. They are locally aggressive tumours, with a high rate of recurrence and associated malignancy. Read More

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http://dx.doi.org/10.11604/pamj.2019.33.49.18065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689846PMC
September 2019
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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.

Cell 2019 08;178(5):1088-1101.e15

Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation. Read More

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http://dx.doi.org/10.1016/j.cell.2019.07.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818271PMC

Clinical usefulness of temporal subtraction CT in detecting vertebral bone metastases.

Eur J Radiol 2019 Sep 19;118:175-180. Epub 2019 Jul 19.

Department of Radiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Purpose: The purpose of this study was to determine whether temporal subtraction (TS) computed tomography (CT) contributes to the detection of vertebral bone metastases.

Method: The calculation of TS CT was composed of bony landmark detection, bone segmentation with a multiatlas-based method, and spatial registration. Temporal increase and decrease of the CT values were visualized in blue and red, respectively. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.07.024DOI Listing
September 2019

Imaging of Third Window Lesions of the Temporal Bone.

Authors:
Gul Moonis

Semin Roentgenol 2019 Jul 12;54(3):276-281. Epub 2019 Apr 12.

Department of Radiology, Columbia University Irving Medical Center, New York, NY. Electronic address:

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http://dx.doi.org/10.1053/j.ro.2019.04.001DOI Listing

Large Intraosseous Schwannoma in Petrous Apex Presenting with Intratumoral Hemorrhage.

World Neurosurg 2019 Nov 31;131:53-57. Epub 2019 Jul 31.

Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Background: Intracranial schwannomas are rarely confined to the skull. We here report a large schwannoma localized in the petrous apex that presented with intratumoral hemorrhage.

Case Description: A 35-year-old woman with mild hearing disturbance and ear fullness underwent computed tomography scan and magnetic resonance imaging, which demonstrated a tumor accompanied with intratumoral hematoma in the right petrous apex. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.07.179DOI Listing
November 2019

Primary temporal bone chondrosarcoma: experience with 10 cases.

Acta Otolaryngol 2019 Oct 2;139(10):837-842. Epub 2019 Aug 2.

ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University , Shanghai , China.

Temporal bone chondrosarcoma (TBC) are uncommon primary temporal bone malignancies, and clinicians lack experience in its diagnosis and treatment. The optimal management of patients with tumor of TBC also remains a topic of debate and controversy. This article summarizes the experience of diagnosis and treatment of TBC, in order to improve the quality of life of cancer patients in the future. Read More

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http://dx.doi.org/10.1080/00016489.2019.1641220DOI Listing
October 2019
0.990 Impact Factor

Histological characteristics of intra-temporal facial nerve paralysis in temporal bone malignancies.

Laryngoscope 2020 May 1;130(5):E358-E367. Epub 2019 Aug 1.

Department of Otolaryngology, Massachusetts Eye and Ear, Boston, Massachusetts, U.S.A.

Objective: To describe the histopathologic findings and clinical presentation of intra-temporal facial nerve invasion in primary and metastatic malignancies of the human temporal bone (TB).

Materials And Methods: Retrospective analysis of all medical records of patients diagnosed with peripheral facial nerve palsy (PFnP) of a malignant origin was performed. Temporal bones underwent standard processing for histologic examination. Read More

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http://dx.doi.org/10.1002/lary.28212DOI Listing
May 2020
3 Reads