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Blood 2022 Jun;139(23):3450

University of Texas Medical Branch.

Zhonghua Bing Li Xue Za Zhi 2022 Jun;51(6):506-511

Department of Pathology, Xuzhou Medical University, Xuzhou 221000, China Department of Pathology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China.

To investigate the clinicopathological features and misdiagnosis factors of ALK positive large B-cell lymphoma (ALKLBCL). The clinicopathological data of 3 patients with ALKLBCL in the Department of Pathology, the Affiliated Hospital of Xuzhou Medical University from 2010 to 2021 were collected retrospectively. Immunohistochemistry (IHC) was used for immunophenotyping, in-situ hybridization (ISH) for EBV-encoded RNA (EBER) detection, in-situ fluorescence hybridization (FISH, break-apart probes) for ALK, MYC, and CCND1 translocations. Read More

Zhonghua Bing Li Xue Za Zhi 2022 Jun;51(6):494-499

Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To investigate the clinical, histologic, immunohistochemical (IHC) and molecular genetic features of clear cell carcinoma (CCC) of salivary gland in the head and neck regions. Seven cases of CCC diagnosed in the Department of Pathology, the First Affiliated Hospital of Nanjing Medical University from 2018 to 2021 were included. The clinical and pathologic data, HE sections and IHC staining were reviewed, and EWSR1 gene translocation was detected by fluorescence in situ hybridization (FISH). Read More

World J Clin Cases 2022 May;10(14):4648-4653

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 23000, Anhui Province, China.

Background: Pleomorphic adenoma (PA) is the most common type of salivary gland tumor, and its common sites are parotid gland, sinus, nasal septum and cleft palate. PA is an uncommon benign type of tumor occurring in the breast, and there are few reports of cases in Asia.

Case Summary: An 84-year-old woman found a mass in the upper outer quadrant of the right breast > 1 year ago. Read More

Cancer Cytopathol 2022 May 31. Epub 2022 May 31.

Department of Pathology, The Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA.

Background: Mucoepidermoid carcinoma (MEC) is the most common salivary gland (SG) malignancy. In this study, the author undertook analysis of a large collection of MEC cytologic cases.

Materials And Methods: Cytopathology files were searched for MEC cases with histopathologic confirmation. Read More

J Oral Maxillofac Res 2022 Jan-Mar;13(1):e5. Epub 2022 Mar 31.

Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of AthensGreece.

Background: Oral melanocytic nevi are relatively rare in comparison to their cutaneous counterparts. The aim of this manuscript is to present a case of acquired compound oral melanocytic nevi on the hard palatal mucosa of a child.

Methods: A 5-year-old female girl was referred for evaluation of a pigmented lesion on the hard palate. Read More

Anticancer Res 2022 May;42(5):2771-2774

Department of Oral and Maxillofacial Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background/aim: Handgrip strength has been used to evaluate the potential of elderly patients to survive different medical conditions or procedures, or to predict the nutritional status and length of hospitalization. The aim of this study was to evaluate the use of handgrip strength as a predictor of the length of hospitalization and need for prolonged intensive care in patients with oral malignancies requiring surgical resection and simultaneous primary reconstruction with microvascular free flap.

Patients And Methods: This is a retrospective study of 37 head and neck carcinoma patients operated between 2012 and 2014 who had undergone a handgrip force test. Read More

J Med Case Rep 2022 Apr 29;16(1):178. Epub 2022 Apr 29.

Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, 3311-1 Yakushiji , Shimotsuke-shi, Tochigi, 329-0498, Japan.

Background: It is very important to determine the indication of mold radiotherapy for the radical treatment of oral cancer. We investigated eight patients with oral squamous cell carcinoma who were treated by radical irradiation with mold radiotherapy using a customized device.

Methods: The subject is a case of curable superficial oral cancer of a few millimeters, or cancer of a size that can be cured by the placement of the radiation source. Read More

Malays J Pathol 2022 Apr;44(1):121-127

Universiti Malaya, Faculty of Dentistry, Department of Oral and Maxillofacial Clinical Sciences, Kuala Lumpur, Malaysia.

Acinic cell carcinoma is an uncommon malignant salivary gland tumour accounting for approximately 6-7% of all salivary gland neoplasms. The key diagnostic feature of acinic cell carcinoma is the presence of acinar cell differentiation characterised by cytoplasmic zymogen secretory granules. This tumour shows a variety of growth patterns, including solid, microcystic, follicular and papillary cystic patterns. Read More

BMJ Case Rep 2022 Apr 8;15(4). Epub 2022 Apr 8.

Otolaryngology, Glangwili General Hospital, Carmarthen, UK.

We present a case report of a gentleman presenting with a globular lesion arising from his uvula. Although elective admission was planned, he presented with airway compromise, and emergency excision was required. The patient had a background of metastatic clear cell renal carcinoma; histology confirmed the uvula lesion as a further secondary deposit. Read More

BMC Oral Health 2022 04 8;22(1):114. Epub 2022 Apr 8.

Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.

Background: This prospective randomized clinical trial aimed to evaluate the immediate and short-term skeletal, dentoalveolar, and periodontal effects of rapid palatal expansion (RPE) and miniscrew-assisted RPE (MARPE) in adolescent and young adult patients.

Methods: This study followed a two-arm, parallel, randomized clinical trial design that recruited patients with transverse maxillary deficiency in a 1:1 allocation ratio. Forty patients (14 men and 26 women) requiring maxillary expansion were randomly allocated to the RPE (n = 20, age = 14. Read More

BMJ Case Rep 2022 Mar 30;15(3). Epub 2022 Mar 30.

Oral and Maxillofacial Pathology & Microbiology, Institute of Dental Sciences, Siksha 'O' Anusandhan deemed to be University, Bhubaneswar, Odisha, India

Primary amelanotic melanoma is an infrequent occurrence in the oral cavity. Owing to the high rate of local invasion and distant metastasis, oral amelanotic melanoma (OAM) carries a very poor prognosis. The absence of pathognomonic clinical and routine histological features in OAM is the reason for diagnosticdelay, which further worsens the prognosis. Read More

Clin Adv Periodontics 2022 Mar 30. Epub 2022 Mar 30.

Western Norway Familial Cancer Center, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.

Introduction: Patients with the PTEN hamartoma tumor syndrome (PHTS) have an 81%-90% cumulative lifetime risk of developing cancer. Around 90% of these patients have recognizable oral features. Receiving a diagnosis may save these patients' lives. Read More

Eur J Med Genet 2022 May 26;65(5):104472. Epub 2022 Mar 26.

Department of Dermatology, Medical Center - University of Freiburg, Freiburg, Germany. Electronic address:

Cutis marmorata telangiectatica congenita (CMTC) is characterized by coarse-meshed capillary malformations arranged in asymmetrically distributed patches. The disorder may be associated with hyper- or hypoplastic limbs, syndactyly, cleft palate, and glaucoma. Because the disease usually occurs sporadically, the concept of a lethal mutation surviving by mosaicism was proposed about 30 years ago. Read More

BMC Neurol 2022 Mar 24;22(1):118. Epub 2022 Mar 24.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, NICU, Milan, Italy.

Background: Pallister-Hall syndrome (OMIM #146510) is a rare autosomal dominant condition caused by a mutation in the GLI3 gene. The cardinal feature of Pallister-Hall syndrome is the presence of hypothalamic hamartomas, which may manifest with seizures, panhypopituitarism and visual impairment. In Pallister-Hall syndrome, dysplastic histogenetic processes responsible for hypothalamic hamartomas are thought to disrupt early craniofacial development. Read More

Oral Oncol 2022 04 18;127:105821. Epub 2022 Mar 18.

Dr. D.Y. Patil Dental College & Hospital, Dr. D.Y. Patil Vidyapeeth, Maharashtra State, Pune, India.

BMJ Case Rep 2022 Mar 16;15(3). Epub 2022 Mar 16.

Department of Odontostomatology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Catalonia, Spain

We report the case of a 3-year-old girl referred to our hospital dentistry service, from a public health centre, due to a 4-week-old swelling in the area of the hard palate, causing displacement of the deciduous tooth and the appearance of an interincisal diastema. The clinical characteristics suggested the possibility of a reactive fibroma and we decided to intervene surgically by means of an excisional biopsy. Histology confirmed the presumptive diagnosis. Read More

Head Face Med 2022 Mar 16;18(1):10. Epub 2022 Mar 16.

Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.

Background: This study evaluated the clinical outcomes of the patients with adenoid cystic carcinoma (ACC) of the minor salivary glands of the palate.

Methods: Forty-four patients with stage I-II disease and 14 patients with stage III-IV disease underwent radical excision and reconstruction with a facial-submental artery island flap (FSAIF) and titanium mesh plus a free anterolateral thigh flap (ALTF) and radiotherapy respectively. Patients with stage III-IV disease subsequently received cobalt Co 60 adjuvant radiotherapy. Read More

Niger J Clin Pract 2022 Mar;25(3):368-372

Department of Otorhinolaryngology, College of Medicine, University of Nigeria, Ituku- Ozalla, Enugu, Nigeria.

Background: Tumors of the minor salivary glands (MSGs) are rare. They constitute a wide range of histologic types despite their low frequency.

Aim: The aim of this study is to evaluate the clinical and pathological features of 11 different tumors of MSGs presented at the University of Nigeria Teaching Hospital Ituku-Ozalla, Enugu and to compare them with similar studies done elsewhere. Read More

J Oral Maxillofac Pathol 2021 Sep-Dec;25(3):470-477. Epub 2022 Jan 11.

Gnanam and Rajamurugan Dental Clinic, Venkatapuram, Ambattur, Chennai, Tamil Nadu, India.

Introduction: Oral malignancies account for about 4% in males and 2% in females among all malignant tumors. Tobacco use in the oral cavity can cause potentially malignant disorders such as oral submucous fibrosis (OSMF), leukoplakia and oral squamous cell carcinoma (OSCC). Factors such as lifestyle changes, habits and limited access to health care increase cancer development and morbidity. Read More

J Oral Maxillofac Pathol 2021 Sep-Dec;25(3):490-493. Epub 2022 Jan 11.

Department of Oral Pathology and Microbiology, M. A. Rangoonwala College of Dental Science and Research Centre, Pune, Maharashtra, India.

Background: Salivary gland tumors are rare and clinically represent a diverse group of neoplasms among which mucoepidermoid carcinoma (MEC) is a relatively common salivary gland tumor with varying potential for aggressive behavior. The purpose of the study was aimed at to analyze the relative frequency and correlate with age, sex, anatomical site and histological grade of MEC and compare the findings with epidemiological data from different geographic locations.

Materials And Methods: Twenty-five cases diagnosed with MEC during the period June 1985 to June 2004 (19 years) were retrieved from the Department of Pathology, Government Medical College and Hospital, Ambajogai, and clinical data were recorded and reviewed histopathologically. Read More

Oral Oncol 2022 04 7;127:105799. Epub 2022 Mar 7.

Oral Oncology Center, São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio St, SP 15050-015 Araçatuba, São Paulo, Brazil; Department of Diagnosis and Surgery, São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio St, SP 15050-015 Araçatuba, São Paulo, Brazil. Electronic address:

Tobacco and alcohol consumption are the main risk factors for head and neck cancer (HNC). However, some individuals do not have a history of addiction and even so they develop the disease. This study evaluated clinicopathological and prognostic features of non-smoking and non-drinking (NSND) HNC patients. Read More

Oral Dis 2022 Jul 22;28(5):1369-1386. Epub 2022 Mar 22.

Stomatology Clinic, Dental School, State University of Montes Claros (UNIMONTES), Montes Claros, Brazil.

Objective: To summarize the clinical evidence on the relationship between cancer and non-syndromic oral cleft (NSOC).

Methods: The review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist, and a literature search was conducted in six databases and gray literature. Studies published in any language mentioning cancer in patients with NSOC and their relatives and NSOC in patients with cancer and their relatives were included. Read More

Head Neck Pathol 2022 Mar 7. Epub 2022 Mar 7.

Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.

Human papillomavirus (HPV)-related benign papillary epithelial neoplasms are common lesions affecting any region of the oral cavity. This study evaluated the trends in frequency, location, and demographics of these lesions over 20 years in a large biopsy service. Following IRB approval, the archives of UF Oral Pathology Biopsy Service between 1995 and 2015 were queried. Read More

Lasers Surg Med 2022 Jul 7;54(5):682-687. Epub 2022 Mar 7.

Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.

Objectives: This study aimed to review the results of oral leucoplakia (OL) using ablative fractional laser-assisted photodynamic therapy (AFL-PDT) and to further evaluate the risk factors for recurrence and malignant transformation.

Materials And Methods: Forty-eight patients diagnosed with OL using histopathology were enrolled in this study. All patients received one session of AFL-PDT. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Mar;36(3):194-197

Department of Head and Neck Surgery，Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya Medical School，Central South University，Changsha，410013，China.

To explore the value of nasal endoscopy assisting combined with transoral approach in resection of the carcinoma of the palate with the nasal cavity and sinuses invaded. A retrospective analysis of 21 patients with a primary malignant tumors of the palate was performed. Preoperative nasal endoscopy and CT and MRI scan showed that the primary tumors invading the nasal cavity and sinuses in all patients or skull base with varying degrees. Read More

Oral Oncol 2022 03 18;126:105779. Epub 2022 Feb 18.

Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.

Introduction: Sinonasal undifferentiated carcinoma (SNUC) is a rare tumor highly aggressive most frequently arise in the maxillary sinus and nasal cavity. Oral involvement is extremely rare.

Case Report: A 62-years-old male presents a large infiltrative mass involving the hard palate and left alveolar ridge. Read More

Oral Oncol 2022 03 17;126:105762. Epub 2022 Feb 17.

Department of Pathology, Federal University of Santa Catarina, Florianópolis, SC, Brazil.

Low-Grade Myofibroblastic sarcoma (LGMS) is categorized as an extremely rare malignant neoplasia of myofibroblasts, which has only recently become more widely studied. Our patient was referred for evaluation of a nodule involving the palate. The histopathological analysis showed a mesenchymal tumor formed for stellate-shaped cells. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Feb;36(2):130-135

1Department of Otolaryngology Head and Neck Surgery，the Second Affiliated Hospital of Xi'an Jiaotong University，Xi'an，710004，China.

The aim of this study is to analyze the application value of NBI endoscopy in finding the concealed primary lesions of misdiagnosis of oropharyngeal cancer. The clinical data of patients with missed oropharyngeal cancer treated in the Department of Otolaryngology Head and neck surgery, the Second Affiliated Hospital of Xi'an Jiaotong University from May 2018 to June 2021, were retrospectively studied, and the missed diagnosis was also analyzed combined with results of NBI endoscopy. In 31 cases of misdiagnosis of oropharyngeal cancer patients, including 25 males and 6 females, there was no significant difference in age, BMI index, course of disease and TNM stage （> 0. Read More

Einstein (Sao Paulo) 2022 14;20:eRC5724. Epub 2022 Feb 14.

Universidade Metropolitana de Santos, Santos, SP, Brazil.

Mammary analogue secretory carcinoma is a rare neoplasm usually confused with other neoplasms in the salivary glands region. It has great similarity with the breast carcinoma. We report a case of a patient who presented with gingival submucosal bleeding and lesion, with the initial histopathological examination revealing salivary gland neoplasm of low crane. Read More