5,438 results match your criteria Malignant Tumors of the Palate


Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases.

J Clin Med 2020 04 18;9(4). Epub 2020 Apr 18.

Department of Emergency and Organ Transplantation - Section of Pathological Anatomy, University of Bari Aldo Moro, Italy, Piazza G. Cesare, 11, 70124 Bari, Italy.

Aims: To report on the clinico-pathological features of a series of 14 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth.

Materials And Methods: All mucoepidermoid carcinomas diagnosed in the period 1990–2012 were retrieved; the original histological preparations were reviewed to confirm the diagnosis and from selected cases, showing exclusive intra-cystic neoplastic components, additional sections were cut at three subsequent 200 m intervals and stained with Hematoxylin–Eosin, PAS, Mucicarmine and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Additionally, pertinent findings collected from the clinical charts and follow-up data were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9041157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231055PMC

Trends in Incidence of Cancers of the Oral Cavity and Pharynx - United States 2007-2016.

MMWR Morb Mortal Wkly Rep 2020 Apr 17;69(15):433-438. Epub 2020 Apr 17.

Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC.

Cancers of the oral cavity and pharynx account for 3% of cancers diagnosed in the United States* each year. Cancers at these sites can differ anatomically and histologically and might have different causal factors, such as tobacco use, alcohol use, and infection with human papillomavirus (HPV) (1). Incidence of combined oral cavity and pharyngeal cancers declined during the 1980s but began to increase around 1999 (2,3). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15585/mmwr.mm6915a1DOI Listing

Pathogenesis and Treatment of Pancreatic Cancer Related Pain.

Anticancer Res 2020 Apr;40(4):1789-1796

Center for Therapeutic Innovation, Miller School of Medicine, University of Miami, Miami, FL, U.S.A.

Pancreatic cancer is often diagnosed due to the patient seeking medical attention for abdominal pain. It is among the most painful cancers, with pain severity strongly correlating with prognosis. Perineural invasion is a prominent feature of pancreatic cancer and often the first route of metastasis resulting in neuropathic pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.14133DOI Listing

Epithelial-Myoepithelial Carcinoma of the Palate: Report of a Case and Review of the Literatures.

Iran J Pathol 2020 26;15(2):144-150. Epub 2019 Dec 26.

Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Epithelial-myoepithelial carcinoma (EMC) is considered as a rare malignant salivary gland neoplasm with good prognosis, low recurrence rate and rare metastasis. Here we present a case of epithelial-myoepithelial carcinoma in a 42-year-old female with a swelling of 3-year duration in her palate. Histopathologic evaluation of the lesion demonstrated a well-circumscribed, biphasic salivary gland tumor composed of double-layered ductal/glandular structures, composed of small luminal eosinophilic cells and abluminal larger clear myoepithelial cells, and luminal cells were positive for pan-cytokeratin, while the abluminal cells exhibited strong immunoreactivity for p63. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.30699/ijp.2020.105039.2076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081763PMC
December 2019

CCL18 overexpression predicts a worse prognosis in oral squamous cell carcinoma (OSCC).

Neoplasma 2020 May 24;67(3):700-706. Epub 2020 Mar 24.

Department of Oral and Maxillofacial Surgery, Capital Medical University School of Stomatology, Capital Medical University, Beijing, China.

Oral squamous cell carcinoma (OSCC) presents severe morbidity and high mortality owing to local recurrence or remote metastasis. Molecular markers, including chemokines, might provide more efficient prognostic information or even therapeutic targets for the treatment of OSCC. Using quantitative RT-qPCR, we found that CCL18 was dramatically overexpressed in 30 OSCC tissues at the mRNA level in comparison with their adjacent non-cancerous oral mucosa tissues and 15 oral mucosa tissues from non-malignant patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4149/neo_2020_190821N802DOI Listing

Symptomatic oral squamous papilloma of the uvula - a rare incidental finding.

Malays Fam Physician 2019 31;14(3):74-76. Epub 2019 Dec 31.

MD (UKM) MMed (ORL-HNS)(UKM) Hospital Tuanku Ja'afar Seremban Malaysia.

Oral squamous papillomas are benign neoplasms of the oral cavity that occur commonly on the palate. Albeit benign and often asymptomatic, they may still cause concern due to their appearance, which may mimic other malignant oral pathologies. Human papillomavirus (HPV) is usually implicated in papilloma pathogenesis. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067511PMC
December 2019

A case report of squamous papilloma of the hard palate in a pediatric patient.

J Indian Soc Pedod Prev Dent 2020 Jan-Mar;38(1):91-93

Department of Pedodontics, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India.

Oral squamous papillomas are benign proliferating lesions induced by human papillomavirus. These lesions are painless and slowly-growing masses. As an oral lesion, it raises concern because of its clinical appearance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/JISPPD.JISPPD_71_18DOI Listing

Head and Neck Cancer Patients' Quality of Life: Analysis of Three Instruments.

J Dent (Shiraz) 2020 Mar;21(1):31-41

Postgraduate Program in Dental Science, Cuiabá Dental School, Universidade de Cuiabá, Cuiabá, MT, Brazil.

Statement Of The Problem: Head and neck cancer treatment has provided better cure and survival rates but the patient's quality of life is still an issue.

Purpose: To verify the correlation between the three most used instruments for evaluating the quality of life of head and neck cancer patients.

Materials And Method: This cross-sectional study evaluated patients treated for head and neck cancer at the Mato Grosso Cancer Hospital, Cuiabá, MT, Brazil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.30476/DENTJODS.2019.77677.0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036356PMC

Clinicopathologic Analysis of Oral and Maxillofacial Solitary Fibrous Tumor.

Am J Clin Pathol 2020 Mar 5. Epub 2020 Mar 5.

Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil.

Objectives: The aim of this systematic review was to provide an overview of the oral and maxillofacial solitary fibrous tumor (SFT) in order to determine its clinicopathologic characteristics and biological behavior.

Methods: We conducted a systematic review in May 2019 in multiple databases. Cases diagnosed as SFT in the oral cavity and maxillofacial complex were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa027DOI Listing

A rare case of long-standing mucoepidermoid carcinoma of minor salivary glands of the palate.

Stomatologija 2019 ;21(3):92-96

Oral Medicine and Radiology, A B Shetty Memorial Institute of Dental Sciences. Nitte University, Deralakatte, Mangalore, 575018 India.

Salivary gland carcinomas are the uncommon and clinically diverse group of neoplasms with mucoepidermoid carcinoma (MEC) being the most common among them. MEC accounts for 5% of all salivary gland tumors. As the name implies, the tumor is composed of both mucus secreting cells and epidermoid type cells in varying proportions. Read More

View Article

Download full-text PDF

Source

A Case of Fibrolipoma of the Hard Palate.

Bull Tokyo Dent Coll 2020 Mar 20;61(1):53-60. Epub 2020 Feb 20.

Department of Oral and Maxillofacial Surgery, Tokyo Dental College Chiba Dental Center.

An extremely rare case of fibrolipoma in the hard palate is presented and discussed with reference to the literature. An 85-year-old woman visited the Tokyo Dental College Chiba hospital in September 2016 with the chief complaint of a mass in the hard palate. The patient had first become aware of this mass several years earlier. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2209/tdcpublication.2019-0010DOI Listing

[Cervical lymph node metastasis in adenoid cystic carcinoma of the salivary glands: A clinicopathologic study].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):30-34

Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To investigate the incidence and clinicopathologic features of cervical lymph node metastasis in salivary gland adenoid cystic carcinoma (AdCC).

Methods: Retrospective analysis was made in 798 AdCC patients who underwent tumor resection during January, 2001 to January, 2019 in Peking University School and Hospital of Stomatology, especially the clincopathologic characteristics of 82 cases with lymph node metastasis.

Results: In the study, 82 of the 798 patients were identified with cervical lymph node metastasis, which was confirmed by histopathological examination. Read More

View Article

Download full-text PDF

Source
February 2020

Soft tissue reconstruction with anterior pedicled inferior turbinate flap in conjunction with palatal flap for standard inferior maxillectomy with hard palate resection.

Head Neck 2020 May 5;42(5):1110-1114. Epub 2020 Feb 5.

Department of Otolaryngology, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.

Background: The defect after surgical resection of sinonasal malignant tumors is normally reconstructed using free flaps obtained from donor sites. There is no report of using the palatal island flap to reconstruct defects after surgery. We aimed to describe our technique of soft tissue reconstruction through anterior pedicled inferior turbinate (APIT) flap in conjunction with palatal flap for standard inferior maxillectomy with hard palate resection and its outcomes and to discuss its advantages and disadvantages compared with free-flap reconstruction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.26091DOI Listing

The role of immune restoration using highly active antiretroviral therapy in the management of AIDS-related Kaposi's sarcoma coexisting with pulmonary tuberculosis.

Niger Postgrad Med J 2020 Jan-Mar;27(1):63-66

Department of Medicine, Infectious Disease Unit, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.

A 35-year-old highly active antiretroviral therapy (HAART)-naïve woman diagnosed 2 years earlier presented with complaints of cough, fever and progressive weight loss of 5 months and skin rashes of 2 months. Clinical examination revealed a chronically ill-looking young woman who was wasted and pale, with purplish flat-topped papules and nodules on the skin of her neck, trunk, forearms and thighs. She also had a single lesion on the hard palate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/npmj.npmj_102_19DOI Listing

Utility of Fine Needle Aspiration in Diagnosis of Intraoral Minor Salivary Gland Tumors.

J Cytol 2020 Jan-Mar;37(1):53-57. Epub 2019 Dec 23.

Department of ENT, Maulana Azad Medical College, New Delhi, India.

Objective: To evaluate the utility of intraoral fine-needle aspiration cytology (FNAC) in diagnosis of minor salivary gland neoplasms (MSGN) with application of Milan system of reporting salivary gland cytopathology; keeping histopathology as gold standard and to detail the cytological findings of MSGNs.

Method: Retrospective study between Jan 2008 and June 2017 (appro × 10 years) on the cytology of the minor salivary gland tumor along with the histopathological correlation. The relevant clinical data was collected from the medical record. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/JOC.JOC_62_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947729PMC
December 2019

[Genetic analysis of a family of Van der Woude syndrome].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2019 Jun;48(4):378-383

Key Laboratory of Reproductive Genetics, Ministry of Education, Department of Reproductive Genetics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.

Objective: To analyze clinical and genetic features of a family affected with Van der Woude syndrome.

Methods: The umbilical cord blood of the proband and the peripheral blood of the parents were used for the whole exon sequencing to find the candidate gene.Peripheral blood of 9 members of the family were collected for Sanger sequencing verification, bioinformatics analysis and genotype-phenotype correlation analysis. Read More

View Article

Download full-text PDF

Source

Clinical course and survival in patients with squamous cell carcinoma of the maxillary alveolus and hard palate: Results from a single-center prospective cohort.

J Craniomaxillofac Surg 2020 Jan 13;48(1):111-116. Epub 2019 Dec 13.

Department Oral and Maxillofacial Surgery, University Hospital of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.

Objectives: Operative management of squamous cell carcinoma of the maxillary alveolus and hard palate (MHSCC) is still a controversial issue, especially for cN0 cases. We report the survival outcomes in patients with MHSCC, including the rate of cervical occult metastasis for UICC stages I/II and survival after elective neck dissection (END).

Methods: 77 patients with primary MHSCC were followed-up from 2 months to 14. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcms.2019.12.008DOI Listing
January 2020

Primary Epithelial Minor Salivary Gland Tumors in South Africa: A 20-Year Review.

Head Neck Pathol 2019 Dec 23. Epub 2019 Dec 23.

Department of Oral Pathology, Faculty of Health Sciences, University of the Witwatersrand, Private Bag 3, WITS, 2050, Johannesburg, South Africa.

Minor salivary gland tumours represent 9-25% of all salivary gland tumours. South African epidemiological reports on minor salivary gland tumours are lacking. This study aims to evaluate the frequency, epidemiology and histology of minor salivary gland tumours in a defined South African population from 1997 to 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12105-019-01111-4DOI Listing
December 2019

Unique Patterns of Distant Metastases in HPV-Positive Head and Neck Cancer.

Oncology 2020 17;98(3):179-185. Epub 2019 Dec 17.

Division of Hematology and Oncology, UT Southwestern Medical Center, Dallas and Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas, USA,

Background: HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC) demonstrates favorable outcomes compared to HPV-negative SCC, but distant metastases (DM) still occur. The pattern of DM in HPV+ HNSCC is unclear.

Methods: 1,494 HNSCC patients were treated from 2006 to 2012. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000504651DOI Listing

Salivary Gland Tumors: A Clinicopathologic Analysis From Taipei Veterans General Hospital.

Ann Plast Surg 2020 Jan;84(1S Suppl 1):S26-S33

Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Background: The aim of this study was to investigate the epidemiological and clinical characteristics of salivary gland tumors (SGTs) in a Taiwanese population and to provide data for comparison with other studies in various locations and racial populations.

Methods: We retrospectively analyzed the medical records of 559 patients with tumors of the salivary glands who were surgically treated from 2002 to 2017 at a single institution.

Results: There were 430 benign and 129 malignant tumors with a mean age of 53. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SAP.0000000000002178DOI Listing
January 2020

Clinical difference between benign and malignant tumors of the hard palate.

Eur Arch Otorhinolaryngol 2020 Mar 11;277(3):903-907. Epub 2019 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, 322, Seoyang-ro, Hwasun, Jeonnam, 58128, South Korea.

Objective: To determine the clinical characteristics and treatment results of benign and malignant tumors of the hard palate in our hospital.

Patients And Methods: A total of 25 patients who underwent surgical treatment for hard palate tumors between 2008 and 2018 were included in this study. Their demographic characteristics, smoking status, alcohol consumption, symptoms, duration of symptoms, size and localization of hard palate tumor, status of mucosal surface, radiologic examinations, surgery, reconstruction method, histopathologic results, treatment outcomes, oral intake start time, adjuvant treatment, postoperative complications, and recurrence were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-019-05759-0DOI Listing
March 2020
1.608 Impact Factor

Nasopharyngeal Hyalinizing Clear Cell Carcinoma: A Case Report and Review of the Literature.

Allergy Rhinol (Providence) 2019 Jan-Dec;10:2152656719889030. Epub 2019 Nov 20.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors which most often arise from the minor salivary glands primarily in palate and tongue but can arise in any location with minor salivary glands including the nasopharynx.

Methods: A case report of primary nasopharyngeal HCCC is presented. Because of the rarity of this tumor and location, a literature search was conducted to determine the most common presenting symptoms, treatment strategies, and outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2152656719889030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883668PMC
November 2019

Oral mucosal melanoma in four Nigerian teaching hospitals.

Niger J Clin Pract 2019 Dec;22(12):1752-1757

Oral Pathology Unit, Department of Oral and Maxillofacial Surgery, Clinical Dental Services, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.

Background: Oral mucosal melanoma (OMM) is a malignant lesion of melanocytes of oral epithelium. The prevalence in four Nigerian teaching hospitals is reported.

Aims: This study shows the hospital based prevalence and the clinicopathologic features of OMM in four Nigerian teaching hospitals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/njcp.njcp_176_19DOI Listing
December 2019

Differences between the oral changes presented by patients with solid and hematologic tumors during the chemotherapeutic treatment.

J Appl Oral Sci 2020 25;28:e20190020. Epub 2019 Nov 25.

Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil.

Objective: This study sought to identify the differences between the oral changes presented by patients with solid and hematologic tumors during chemotherapeutic treatment.

Methodology: This is an observational, prospective and quantitative study using direct documentation by follow-up of 105 patients from 0 to 18 years using the modified Oral Assessment Guide (OAG). Of the 105 patients analyzed, 57 (54. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1678-7757-2019-0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882646PMC
January 2020

Mature Nasopharyngeal Teratoma in a Neonate: Case Report and a Review of Literature.

Indian J Otolaryngol Head Neck Surg 2019 Nov 28;71(Suppl 3):1775-1778. Epub 2017 Apr 28.

Department of Otolaryngology and Head Neck Surgery, Children's Airway and Swallowing Centre, Manipal Hospitals, 98, HAL Airport Road, Bengaluru, India.

Teratomas are true neoplasms that contain tissues foreign to the site in which they arise. They are derived from germ cells with components of the three embryonic layers (ectoderm, mesoderm and endoderm). The present report is about a 10 day old neonate with teratoma arising from the nasopharyngeal surface of the soft palate, which was successfully removed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12070-017-1123-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848549PMC
November 2019

Surgical Management of the Palatal Pleomorphic Adenoma.

Authors:
Seong-Yong Moon

J Craniofac Surg 2019 Sep;30(6):e580-e582

Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, Oral and Maxillofacial Surgery, Gwangju, South Korea.

Introduction: Surgical excision is the basic treatment option of the palatal pleomorphic adenoma (PA), it is generally accepted to prevent for recurrence. The purpose of this study was to determine the decision criteria for the management of the palatal PA through evaluating the postoperative results of palatal PA correlation with the clinical appearance.

Materials And Methods: All of patients were evaluated the mucosal ulceration, palatal erosion, and size with CT images in all 18 palatal PAs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SCS.0000000000005608DOI Listing
September 2019

The prognostic significance of the lymph node ratio in oral cancer differs for anatomical subsites.

Int J Oral Maxillofac Surg 2020 May 16;49(5):558-563. Epub 2019 Nov 16.

Department of Oral and Craniomaxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany; Department of Oral and Craniomaxillofacial Surgery, Saarland University Hospital, Homburg, Germany.

The aim of this study was to validate the prognostic significance of the lymph node ratio (LNR) in patients suffering from oral squamous cell carcinoma in regard to different anatomical subsites. A cohort of 430 patients was investigated to determine the rates of primary metastasis and local and regional disease recurrence. Correlation analysis of the LNR with relevant clinical and pathological parameters was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijom.2019.10.015DOI Listing

Salivary Gland Diseases.

Authors:
Orrett E Ogle

Dent Clin North Am 2020 01 10;64(1):87-104. Epub 2019 Oct 10.

University of The West Indies, Kigston, Jamaica. Electronic address:

A variety of diseases ranging from obstructions, infections, to benign and malignant tumors occur in salivary glands. The most common problem is painful blockage of ducts by stones that prevents drainage of saliva. Sialadenitis can be due to either infectious or noninfectious factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cden.2019.08.007DOI Listing
January 2020

SMARCB1 (INI-1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center.

Head Neck 2020 Mar 15;42(3):374-384. Epub 2019 Nov 15.

Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Background: SMARCB1 (INI-1)-deficient carcinomas and NUT carcinomas are aggressive neoplasms, often affecting the sinonasal region. Not uncommonly, their diagnoses are made retrospectively.

Methods: Through SMARCB1 (INI-1) and NUT immunomarkers, 643 head and neck carcinomas were assessed retrospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.26008DOI Listing

NF1 microdeletion syndrome: case report of two new patients.

Ital J Pediatr 2019 Nov 8;45(1):138. Epub 2019 Nov 8.

Unit of Pediatrics and Pediatric Emergency, University Hospital "Policlinico-Vittorio Emanuele", Catania, Italy.

Background: 17q11.2 microdeletions, which include the neurofibromatosis type 1 (NF1) gene region, are responsible for the NF1 microdeletion syndrome, observed in 4.2% of all NF1 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13052-019-0718-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839219PMC
November 2019

Meta-Analysis of Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways.

Genes (Basel) 2019 10 31;10(11). Epub 2019 Oct 31.

Department of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC, 3086, Australia.

The () and vertebrate - () transcription factors are among the most critical genes for epithelial development, maintenance and homeostasis, and are remarkably well conserved from fungi to humans. Mutations affecting function lead to a myriad of developmental and adult onset epithelial disease, such as aberrant skin barrier formation, facial/palatal clefting, impaired neural tube closure, age-related hearing loss, ectodermal dysplasia, and importantly, cancers of epithelial origin. Recently, mutations in the family member have been shown to lead to both syndromic and non-syndromic facial and palatal clefting in humans, particularly the genetic disorder Van Der Woude Syndrome (VWS), as well as spina bifida, whereas mutations in mammalian lead to exencephaly and facial clefting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes10110876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896185PMC
October 2019

The Role of Biofilms and Material Surface Characteristics in Microbial Adhesion to Maxillary Obturator Materials: A Literature Review.

Cleft Palate Craniofac J 2020 Apr 30;57(4):487-498. Epub 2019 Oct 30.

School of Dentistry and Oral Health, Griffith University, Queensland, Australia.

Background: Maxillofacial prosthetics includes restoration of maxillary defects resulting from resection of palate and nasosinus neoplasms with obturator prostheses which may be colonized by microorganisms and function as a reservoir of infection. Patients with neoplasms commonly also require radiotherapy that can result in changes in saliva quality and quantity and changes in the oral microbial flora. The altered flora, in individuals immunocompromised from cancer therapy, increases their risk of prosthesis-related infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1055665619882555DOI Listing
April 2020
4 Reads

Maxillary reconstruction using tunneling flap technique with 3D custom-made titanium mesh plate and particulate cancellous bone and marrow graft: a case report.

Maxillofac Plast Reconstr Surg 2019 Dec 17;41(1):43. Epub 2019 Oct 17.

1Department of Oral and Maxillofacial Surgery, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo, 101-0061 Japan.

Background: Reconstructive surgery is often required for tumors of the oral and maxillofacial region, irrespective of whether they are benign or malignant, the area involved, and the tumor size. Recently, three-dimensional (3D) models are increasingly used in reconstructive surgery. However, these models have rarely been adapted for the fabrication of custom-made reconstruction materials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40902-019-0228-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797690PMC
December 2019

Warthin-like mucoepidermoid carcinoma of the parotid gland: a diagnostic and therapeutic dilemma.

Autops Case Rep 2019 Oct-Dec;9(4):e2019122. Epub 2019 Sep 30.

All India Institute of Medical Sciences, Department of Surgical Oncology. Bhubaneswar, Sijua, Orissa, India.

Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. Although the parotid gland is the most common site of involvement, other major salivary glands and the minor salivary glands-most commonly of the palate-also can be involved. The management of mucoepidermoid carcinoma depends on the grade of the tumor and the adequacy of resection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4322/acr.2019.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771442PMC
September 2019
1 Read

Clinicopathologic analysis of verrucous hyperplasia, verrucous carcinoma and squamous cell carcinoma as part of the clinicopathologic spectrum of oral proliferative verrucous leukoplakia: A literature review and analysis.

Pathol Res Pract 2019 Dec 25;215(12):152670. Epub 2019 Sep 25.

Rambam medical center, Department of pathology, HaAliya HaShniya St 8, Haifa, 3109601, Haifa, Israel; Technion school of medicine, HaAliya HaShniya St 8, Haifa, 3109601, Haifa, Israel.

Objective: Proliferative verrucous leukoplakia is classified as a potentially malignant disorder because of its high rate of malignant transformation. PVL progresses in a series of clinical stages where the early stage represents multiple, multifocal leukoplakias with a high recurrence rate. The intermediate and late stages are clinically exophytic lesion, diagnosed microscopically as verrucous hyperplasia that often progresses into verrucous carcinoma and/or squamous cell carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prp.2019.152670DOI Listing
December 2019
1 Read

EBV positive mucocutaneous ulcer of palate: A mimicker of malignancy.

Indian J Pathol Microbiol 2019 Oct-Dec;62(4):632-634

Department of Head and Neck Surgery, Fortis Hospitals, New Delhi, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/IJPM.IJPM_51_19DOI Listing

Cavernous hemangioma of uvula: A rare site.

Indian J Pathol Microbiol 2019 Oct-Dec;62(4):631-632

Department of Pathology, Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, Maharashtra, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/IJPM.IJPM_435_18DOI Listing
April 2020
1 Read

Sphenopalatine Ganglion Blocks in the Management of Head and Neck Cancer-Related Pain: A Case Series.

A A Pract 2019 Dec;13(12):450-453

From the Division of Pain Medicine, Department of Anesthesiology, University of Virginia, Charlottesville, Virginia.

Head and neck cancer can be painful, debilitating, and refractory to oral medications. Due to the association of the sphenopalatine ganglion (SPG) with maxillary nerve sensory fibers, SPG blocks may be used to treat the pain of the hard and soft palate, tonsils, nasal cavity, paranasal sinuses, oral gingiva, premaxillary soft tissue, maxilla, and orbital floor. We present the first case series of performing SPG blocks utilizing TX360 nasal atomizers or angiocatheters to treat head and neck cancer-related pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/XAA.0000000000001106DOI Listing
December 2019

Oral neural tumors: Clinicopathologic analysis of 157 cases and review of the literature.

J Clin Exp Dent 2019 Aug 1;11(8):e721-e731. Epub 2019 Aug 1.

MD, DDS, PhD, Professor, Head of Department of Oral Medicine and Pathology, Department of Dentistry, School of Health Sciences, National and Kapodistrian University of Athens, Greece.

Background: Oral neural tumors (ONTs) are rare lesions and represent reactive or neoplastic proliferations of nerve sheath cells. The purpose of the present study is to report the clinical, demographic and histopathologic features of 157 ONTs diagnosed in a single Oral Pathology Department and review the pertinent literature.

Material And Methods: 157 cases of ONTs diagnosed during a 44-year period were retrospectively collected and the diagnosis was reconfirmed by studying representative haematoxylin and eosin stained tissue sections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4317/jced.55944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776406PMC
August 2019
1 Read

The Phase 1/2 ACCEPT Trial: Concurrent Cetuximab and Intensity Modulated Radiation Therapy with Carbon Ion Boost for Adenoid Cystic Carcinoma of the Head and Neck.

Int J Radiat Oncol Biol Phys 2020 01 3;106(1):167-173. Epub 2019 Oct 3.

Department of Radiation Oncology, University Hospital Gießen and Marburg (UKGM), Marburg, Germany.

Purpose: The adenoid cystic carcinoma (ACC), Erbitux, and Particle Therapy (ACCEPT) phase 1/2 trial (NCT01192087) evaluated a combined-modality approach (concurrent cetuximab and intensity modulated radiation therapy with carbon ion boost) for newly diagnosed nonmetastatic head and neck ACC.

Methods And Materials: Twenty-three patients with ACC were enrolled between June 2012 and June 2017 after initial diagnosis or postoperatively. All received a 400 mg/m cetuximab loading dose a week before radiation therapy, followed by weekly 250 mg/m doses starting on the first day of radiation therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2019.09.036DOI Listing
January 2020
1 Read

Lymphangioma in the Buccal Mucosa.

J Craniofac Surg 2019 Nov-Dec;30(8):e696-e697

Assistant Professor, Izmir Katip Çelebi University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Turkey.

Lymphangiomas are benign hamartomatous tumors which are characterized by abnormal proliferation of lymphatic vessels. They are lymphatic malformations which are commonly localized to head and neck region. They are rare located in the oral cavity and tongue, lips, buccal mucosa, soft palate, floor of the mouth are mostly affected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SCS.0000000000005582DOI Listing
January 2020
2 Reads

The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function.

Nature 2019 10 2;574(7777):249-253. Epub 2019 Oct 2.

Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.

The integrity of the mammalian epidermis depends on a balance of proliferation and differentiation in the resident population of stem cells. The kinase RIPK4 and the transcription factor IRF6 are mutated in severe developmental syndromes in humans, and mice lacking these genes display epidermal hyperproliferation and soft-tissue fusions that result in neonatal lethality. Our understanding of how these genes control epidermal differentiation is incomplete. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1615-3DOI Listing
October 2019
2 Reads

Solitary plasmacytoma of maxillofacial bones: correlation of CT features with pathological findings.

Authors:
Yu Liu Kaicheng Li

Dentomaxillofac Radiol 2020 Jan 10;49(1):20190277. Epub 2019 Oct 10.

Department of Radiology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China.

Objective: To explore the CT features of solitary plasmacytoma (SP) of maxillofacial bones and correlation with pathological findings.

Methods And Materials: We retrospectively reviewed the clinical, CT and pathological features of SP in the maxillofacial bones. 16 patients with clinically and histologically proven SP of maxillofacial bones were involved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1259/dmfr.20190277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957068PMC
January 2020

Pleomorphic adenoma: a rare presentation in buccal salivary gland with extensive squamous and mucous metaplasia.

Pan Afr Med J 2019 26;33:147. Epub 2019 Jun 26.

Department of Oral Medicine and Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Pleomorphic Adenoma (PA) is the most common salivary gland tumor and accounts for about 60% of all salivary gland neoplasms. Intraorally, the hard palate is the most common presenting site (50-60%) followed by upper lip (15-20%) and rarely buccal mucosa (8-10%). Histopathologically, PA shows diverse morphology resulting from amalgamation of cellular and stromal components. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2019.33.147.17550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754833PMC
October 2019
5 Reads

[Giant teratoma of nasopharynx with cleft palate and lingual hamartoma in the newborn: a case report].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Sep;54(9):695-697

Department of Otorhinolaryngology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.09.011DOI Listing
September 2019

Elective neck dissection (END) and cN0 hard palate and upper gingival cancers: A National Cancer Database analysis of factors predictive of END and impact on survival.

J Surg Oncol 2019 Dec 23;120(7):1259-1265. Epub 2019 Sep 23.

Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York.

Background And Objectives: The reported risk of nodal metastasis in hard palate and upper gingival squamous cell carcinoma (SCC) has been inconsistent with inadequate consensus regarding the utility of neck dissection in the clinically negative (cN0) neck.

Materials And Methods: Using the National Cancer Database, cN0 patients diagnosed with SCC of the head and neck with the subsites of the hard palate and upper gingiva were identified from 2004 to 2014.

Results: A total of 1830 patients were identified, and END was performed on 422 patients with cN0 tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25706DOI Listing
December 2019
2 Reads

High Grade Transformation in Mucoepidermoid Carcinoma of the Minor Salivary Gland with Polyploidy of the Rearranged MAML2 Gene.

Head Neck Pathol 2019 Sep 18. Epub 2019 Sep 18.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary gland. However, reports of high grade transformation in MEC are extremely rare, and only two cases have so far been described. Recent development of salivary gland pathology revealed recurrent gene rearrangements in many kinds of tumors, including MAML2 fusion of MEC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12105-019-01064-8DOI Listing
September 2019
3 Reads

A Myriad of Scleroma Presentations: The Usual and Unusual.

Head Neck Pathol 2019 Sep 16. Epub 2019 Sep 16.

Department of Otolaryngology, Alexandria University, 4 Kafr Abdou Street #605, Alexandria, 21529, Egypt.

To prospectively study a series of scleroma patients with a focus on socioeconomic status, clinical presentation, pathology, microbiology, and treatment. A total of 52 patients diagnosed with scleroma were included in the study. Demographic data of the patients were collected and clinical, radiographic, and histopathologic findings were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12105-019-01075-5DOI Listing
September 2019
8 Reads

Case of nasopharyngeal teratoma: challenges in the management.

BMJ Case Rep 2019 Sep 11;12(9). Epub 2019 Sep 11.

Neonatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Teratomas are tumour with tissue or organ components resembling normal derivatives of more than one germ layer. The most common site of congenital teratoma is sacrococcygeal region. Teratomas in head and neck region are rarer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2019-230105DOI Listing
September 2019

Hyperplastic Response Following Soft Tissue Augmentation in the Esthetic Zone.

Clin Adv Periodontics 2019 06 30;9(2):50-54. Epub 2018 Nov 30.

Department of Oral and Maxillofacial Pathology, University of the Western Cape, Cape Town, South Africa.

Introduction: The indications for augmentation of gingival tissue by connective tissue graft (CTG) are numerous. The techniques are widely adopted with extensive literature reporting high success. Harvest techniques include the mid to anterior palate, versus the posterior palate and tuberosity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cap.10047DOI Listing