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Head Neck Pathol 2021 May 12. Epub 2021 May 12.

Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.

Microsecretory adenocarcinoma (MSA) is a recently described salivary gland tumor with a characteristic histologic and immunophenotypic profile and recurrent MEF2C-SS18 fusions. Because only six cases of MSA have been published, its complete clinicopathologic spectrum is unclear, and its biologic behavior has not been documented. Here, we present an updated and expanded experience of 24 MSA cases. Read More

Autops Case Rep 2021 Apr 15;11:e2021244. Epub 2021 Apr 15.

Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba, Departamento de Diagnóstico Oral, Piracicaba, SP, Brasil.

Necrotizing sialometaplasia (NS) is a benign, self-limiting inflammatory entity that mainly affects the minor salivary glands located in the hard palate. Classically, NS is characterized as a nodule that evolves to a central ulcer. The most widely recognized triggering factor is an ischemic event. Read More

Pan Afr Med J 2021 9;38:146. Epub 2021 Feb 9.

Département d´Odontologie Chirurgicale, Faculté de Médecine Dentaire de Rabat, Université Mohammed V, Rabat, Maroc.

Pleomorphic adenoma is a benign mixed tumor, which is composed of myoepithelial and epithelial cells. A fibrous capsule separates these cells from the surrounding tissues. Pleomorphic adenoma is the most common salivary gland tumour accounting for 40-70% of all major and minor salivary gland tumours. Read More

Pan Afr Med J 2021 19;38:61. Epub 2021 Jan 19.

Department of Otorhinolaryngology, Giannitsa General Hospital, Pella, Greece.

Fibromas are benign tumors of connective tissue common in the oral cavity but rare on hard palate. This paper reports on an asymptomatic, slowly growing mass on the hard palate of a 90-year-old lady, with a reported use of denture for two decades. The patient presented with a 2. Read More

Case Rep Dent 2021 24;2021:8853649. Epub 2021 Mar 24.

Dept. of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India.

Background: Polymorphous low-grade adenocarcinoma (PLGA) is a slow growing malignant tumor of minor salivary glands and is generally of indolent nature. However, according to the most recent WHO Classification of Salivary Gland Tumors (2017), the cancer is classified as Polymorphous AdenoCarcinoma (PAC). PAC presents as a less aggressive tumor, though it could on rare occasions demonstrate distant metastasis. Read More

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Oral and Maxillofacial Surgery, Pinderfields Hospital, Mid Yorkshire Hospitals NHS Trust, Wakefield, UK.

Neurofibromas are defined as benign tumours arising from peripheral nerve sheaths. Few intraoral palatal cases have been reported. Neurofibromas can occur as part of neurofibromatosis, type 1 (NF1) or type 2 (NF2). Read More

Int J Environ Res Public Health 2021 03 24;18(7). Epub 2021 Mar 24.

School of Medicine, Vita-Salute San Raffaele University, 20100 Milano, Italy.

Mucosal melanomas of the head and neck region are uncommon pathologies that can affect the oral cavity, and are characterized by a high rate of mortality. Considering the lack of knowledge regarding risk and prognostic factors, current best clinical practice is represented by a large surgical excision with disease-free margins, eventually associated with a reconstructive flap. Indeed, given the frequent necessity of postoperative radiotherapy and fast healing process, a reconstruction of the surgical gap is advisable. Read More

BMJ Case Rep 2021 Mar 25;14(3). Epub 2021 Mar 25.

Department of Oral & Maxillofacial Surgery, Amrita Vishwa Vidyapeetham, Amrita School of Dentistry, Kochi, Kerala, India.

Salivary gland tumours can arise in any location in the oral cavity but are rather rare in the retromolar region. The majority of the salivary neoplasms arising here are malignant in nature. Mucoepidermoid carcinoma is more commonly seen in the palate. Read More

BMJ Case Rep 2021 Mar 24;14(3). Epub 2021 Mar 24.

Department of Otolaryngology/ Head and Neck Surgery, University Hospital Waterford, Waterford, Republic of Ireland.

Nasal-type Natural Killer/T-cell Lymphoma (NKTL) is a rare form of extranodal non-Hodgkin's lymphoma, typically arising in the nasopharynx and displaying an aggressive and ultimately fatal clinical course. The disease is linked to Epstein-Barr virus infection and is endemic to Asia and South America, but extremely few cases have been reported in Europe. We present two cases of nasal NKTL unexpectedly diagnosed in elderly patients, following very different presentations to our otolaryngology service. Read More

Pan Afr Med J 2020 16;37:350. Epub 2020 Dec 16.

Department of Otorhinolaryngology, University Hospital Center Mohammed VI, Marrakesh, Morocco.

Amelanotic malignant melanoma is an extremely rare and aggressive oral tumor. Herein we report the case of a 42-year-old woman presented with a painful growth in anterior maxillary region. Intra-oral examination showed a non-pigmented exophytic mass occupying the anterior maxillary sector. Read More

Gland Surg 2021 Feb;10(2):721-728

Department of Otorhinolaryngology-Head & Neck Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background: Accurate diagnosis of malignancy in the parotid gland before surgery is often challenging. Various clues should be used to increase the index of suspicion for malignancy. We hypothesized that malignant lesions of the parotid gland are located at the superior part of the gland compared to benign ones. Read More

J Clin Exp Dent 2021 Mar 1;13(3):e240-e249. Epub 2021 Mar 1.

PhD, Department of Dentistry, Unichristus, Fortaleza, Ceará, Brazil.

Background: Retrospectively to evaluate the influence of radiochemotherapy (RCT) in the treatment of surgically and non-surgically treated Oral Squamous Cell Carcinoma (OSCC).

Material And Methods: We analysed 934 patients treated in Hospital Haroldo Juaçaba (2000-2014; 15 years of study) by extraction of data type of cancer, localization of tumour, sex, age, race, education level, risk factors (smoking and alcohol use), year of diagnosis, TNM stage, therapeutic approach, health system used (public or private) and overall survival (OS). Surgically and non-surgically treated OSCC were compared by chi-square and Fisher's exact tests, and their prognostic factors were analysed by log-rank Mantel-Cox plus Cox regression tests (SPSS 20. Read More

Head Neck Pathol 2021 Mar 3. Epub 2021 Mar 3.

Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.

Secretory carcinoma (SC) is an uncommon salivary gland neoplasm of the oral cavity that microscopically may mimic acinic cell carcinoma (ACC) and mucoepidermoid carcinoma (MEC). This study describes a series of SC in minor glands with a literature review. We performed a retrospective search for oral SC, within the archives of the University of Florida, Oral Pathology and Surgical Pathology Biopsy services from 2010 to 2018. Read More

J Int Med Res 2021 Feb;49(2):300060521996873

Department of Otorhinolaryngology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Pharyngeal teratomas are very rare congenital tumours derived from pluripotent stem cells. Surgical resection is the main treatment to avoid breathing and feeding difficulties. This current case report describes two newborn infants with congenital oropharyngeal teratomas. Read More

In Vivo 2021 Mar-Apr;35(2):947-953

Department of Oral and Maxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.

The aim of this case report was to detail diagnosis and therapy in a case of implant-associated peripheral giant cell granuloma (IA-PGCG) of the jaw. Case Report: The 41-year-old female attended the outpatient clinic for treatment of recurrent mandibular IA-PGCG. The lesion was excised and the defect was closed with a connective tissue graft of the palate. Read More

Am J Case Rep 2021 Feb 22;22:e929674. Epub 2021 Feb 22.

Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

BACKGROUND Neurofibromas are benign tumors of neurological origin caused by the proliferation of Schwann cells and fibroblasts; they often occur in the skin and nerves as a symptom of von Recklinghausen disease. Solitary neurofibromas are also known to occur on their own, but solitary development in the hard palate is extremely rare and difficult to distinguish from schwannomas. The neural origin of solitary neurofibromas is also difficult to determine intraoperatively, and there have been no reports that clearly identify the neural origin of neurofibromas in the hard palate. Read More

BMJ Case Rep 2021 Feb 19;14(2). Epub 2021 Feb 19.

Oral & Maxillofacial Department, St George's University Hospitals NHS Foundation Trust, London, UK.

Schwannomas or neurilemmomas are slow-growing, benign and often firm lumps that are typically painless. They are extremely rare in the oral cavity, with the tongue and the palate being the most common intraoral sites. This is a case report of this pathology in the floor of the mouth. Read More

J Oral Biosci 2021 03 11;63(1):1-7. Epub 2021 Feb 11.

Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Faculty of Dental Medicine, Hokkaido University, Kita 13 Nishi 7 Kita-ku, Sapporo 060-8586, Japan.

Background: The Journal of Oral Biosciences is devoted to the advancement and dissemination of fundamental knowledge concerning every aspect of oral biosciences.

Highlight: This review featured the review articles in the fields of "Microbiology," "Palate," "Stem Cells," "Mucosal Diseases," "Bone Cell Biology," "MicroRNAs," "TRPV1 Cation Channels," and "Interleukins" in addition to the review article by prize-winners of the "Rising Members Award" ("DKK3 expression and function in head and neck squamous cell carcinoma and other cancers"), presented by the Japanese Association for Oral Biology.

Conclusion: These reviews in the Journal of Oral Biosciences have inspired the readers of the journal to broaden their knowledge regarding the various aspects of oral biosciences. Read More

BMJ Case Rep 2021 Feb 9;14(2). Epub 2021 Feb 9.

Ent Head and Neck Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Dentigerous cyst is one of the most common developmental cyst of the jaw which accounts for approximately 20%-30% of bone cyst in the head and neck region. Most common site is the third molar of the mandible. However, maxillary involvement is not uncommon. Read More

Ann Med Surg (Lond) 2021 Feb 5;62:37-42. Epub 2021 Jan 5.

Department of Medical and Surgical Sciences, Division of Plastic Surgery, University of Modena and Reggio Emilia, Policlinico of Modena, Largo Pozzo 71, 41124, Modena, Italy.

Since the introduction of fibula flap as a reconstructive technique, an evolution of indications has been observed. Our first report of a traumatic mandibular reconstruction using fibula flap was in 1992. The vast majority of indications for surgery, are: malignant tumors, benign neoplasms, osteoradionecrosis and traumas. Read More

Zhongguo Fei Ai Za Zhi 2021 Jan;24(1):63-68

Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu 610041, China.

NUT carcinoma is a rare, high lethal cancer which feature as the rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14, and its pathogenesis and treatment is not yet clear, the prognosis is poor. Due to NUT carcinoma often occurred on the middle position of the body, such as eyes, nose and palate, mediastinum, so it is also called NUT midline carcinoma (NMC). In this case, we report a 70 years old man who was diagnosed as primary pulmonary NUT carcinoma in the Department of Thoracic Oncology, West China Hospital of Sichuan University. Read More

Vestn Otorinolaringol 2020 ;85(6):37-40

Medical Radiological Research Centre - branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia.

According to statistical data given in the article the incidence of oropharyngeal cancer increases, despite the ease of access to the maxillofacial area and the possibility to make visual and manual examination of this site. It should be stressed that locally advanced oropharyngeal cancer of the III-IV stages was the first diagnosis in 82.9% of patients. Read More

Gan To Kagaku Ryoho 2020 Dec;47(13):1774-1776

Dept. of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine.

Treatment of oral cancer is based on radical resection and reconstructive surgery. Surgery causes impairment of maxillofacial morphology and function, including chewing and eating difficulties, and dysarthria. It is necessary to restore the maxillofacial morphology and function by reconstructive surgery and use of prostheses. Read More

Dtsch Arztebl Int 2020 Oct;117(44):751

Int J Surg Case Rep 2021 Jan 16;78:228-234. Epub 2020 Dec 16.

Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Casablanca University Hospital, Casablanca, Morocco.

Introduction: Cancer of the hard palate is a fairly rare malignant tumor. Different histological types have been described in the hard palate, and that can affect its different structures. Diagnosis is based on biopsy with histological examination and possibly on immunohistochemical markers to confirm the diagnosis and exclude other diagnostic hypotheses. Read More

Autops Case Rep 2020 May 6;10(2):e2020156. Epub 2020 May 6.

Ascension St. John Hospital, Department of Pathology. Detroit, Michigan, USA.

Hyalinizing clear cell carcinoma (HCCC), also known as clear cell carcinoma, not otherwise specified [CCC, (NOS)], is a rare minor salivary gland tumor characterized by proliferation of clear cells, organized in trabecular cords, or solid nests within loose to densely hyalinized stroma. It is considered a diagnosis of exclusion by the World Health Organization (WHO) because other salivary tumors may also have a clear cell component. Hence, there is a wide differential diagnosis. Read More

Med Oral Patol Oral Cir Bucal 2021 May 1;26(3):e379-e386. Epub 2021 May 1.

Oral Pathology Section, Department of Oral Diagnosis Piracicaba Dental School, University of Campinas (UNICAMP) Av. Limeira 901, P.O. Box. 52, Piracicaba, São Paulo 1314-903, Brazil

Background: Melanoma is an aggressive malignant tumor, rarely observed in the oral cavity. The aim of this study was to describe the clinicopathologic features of a series of oral melanomas.

Material And Methods: A retrospective descriptive study was performed. Read More

Int J Mol Sci 2020 Dec 8;21(24). Epub 2020 Dec 8.

Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei 11221, Taiwan.

Head and neck squamous cell carcinoma (HNSCC), including oral squamous cell carcinoma (OSCC), ranks sixth in cancer incidence worldwide. To generate OSCC cells lines from human or murine tumors, greatly facilitates investigations into OSCC. This study describes the establishing of a mouse palatal carcinoma cell line (designated MPC-1) from a spontaneous tumor present in a heterozygous gene loss C57BL/6 mouse. Read More

J Vet Diagn Invest 2021 Mar 8;33(2):379-383. Epub 2020 Dec 8.

Clinical Veterinary Science.

A 27-y-old Anglo-Arabian gelding with bay coat color was presented with a swelling of the left maxillary region. Fenestration on the left maxilla revealed that the left maxillary sinus was filled with black-red tissue. A portion of the tissue was excised and diagnosed histologically as malignant melanoma. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Oct;34(10):937-941

Department of Otorhinolaryngology，the First Affiliated Hospital of Chongqing Medical University，Chongqing，400012，China.

To analyze the imaging features of parapharyngeal space tumors, and to guide the choice of treatment. A retrospective analysis of 75 cases' clinical data of parapharyngeal space tumor was carried out. All patients underwent enhanced CT and/or enhanced MRI, those tumors closely related to blood vessels and vascular tumors were examined by CTA or MRA, those closely related to peripheral nerves were examined by MRN. Read More