Search Our Scientific Publications & Authors

J Contemp Brachytherapy 2019 Feb 28;11(1):28-34. Epub 2019 Feb 28.

Department of Radiation Oncology, Peking University Third Hospital, Beijing.

Purpose: The aim of this study was to evaluate the efficacy and safety of interstitial permanent low-dose-rate ultrasound-guided I seeds implantation of local head and neck recurrent tumors.

Material And Methods: Sixty-four consecutive patients, with 81 lesions in total, underwent permanent implantation of I seeds under ultrasound guidance. Post-operative dosimetry was performed for all patients. Read More

Braz Oral Res 2018 Dec 6;32:e123. Epub 2018 Dec 6.

Hospital General de México "Eduardo Liceaga", Department of Pathology, México City, México.

This study aims to evaluate the clinicopathological features, TNM status, AJCC staging and behavior of squamous cell carcinoma of the tongue (SCCT) in patients older than 45 years. The files of the Department of Pathology of the Hospital General de México were reviewed and all cases of SCCT in patients older than 45 years were selected. Clinicopathological features, treatment, follow-up, microscopic diagnosis, and IJCC and TNM staging were retrieved. Read More

Yale J Biol Med 2018 09 21;91(3):215-223. Epub 2018 Sep 21.

Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, UCLA, Los Angeles, CA.

Oral and head and neck squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide. The primary management of OSCC relies on complete surgical resection of the tumor. Margin-free resection, however, is difficult given the devastating effects of aggressive surgery. Read More

Acta Otorhinolaryngol Ital 2018 Jun;38(3):175-180

Department of Otolaryngology, Head and Neck Surgery, Fondazione IRCCS, Istituto Nazionale dei Tumori di Milano, University of Milan, Italy.

Summary: A recent reduction in the number of smoke-related tumours has been observed thanks to the diffusion of anti-tobacco campaigns carried out in the majority of developed countries. Nevertheless, as demonstrated by recent global epidemiologic studies, squamous cell carcinoma of the mobile tongue appears to be progressively increasing in incidence, particularly among young adults and especially in females. The driving mechanism responsible for such changes is still to be precisely defined. Read More

J Oral Pathol Med 2018 Sep 27;47(8):764-772. Epub 2018 May 27.

Research Program Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland.

Background: Certain periodontopathogenic bacteria have been linked to cancers. Treponema denticola (Td) is associated with severe periodontitis. Chymotrypsin-like proteinase (CTLP), a major virulence factor of Td, can degrade various host proteins and peptides, and modulate inflammatory responses. Read More

J Surg Oncol 2018 Apr 12;117(5):1092-1099. Epub 2018 Feb 12.

Maxillo-Facial Surgery Unit, AOU-Careggi, Florence, Italy.

Background And Objectives: Reconstruction of tongue cancer defects is challenging due to the complex anatomy and physiology of the tongue. Here, we classify patterns of tongue tissue loss and describe a treatment algorithm for achieving good functional and oncologic outcomes.

Methods: We retrospectively reviewed 50 tongue squamous-cell carcinomas surgically treated between January 2010-June 2015. Read More

Dysphagia 2018 06 2;33(3):345-357. Epub 2017 Nov 2.

Department of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine, University of Alberta, 8205 114St 2-70 Corbett Hall, Edmonton, AB, T6R 3T5, Canada.

Mobile health (mHealth) technologies may offer an opportunity to address longstanding clinical challenges, such as access and adherence to swallowing therapy. Mobili-T is an mHealth device that uses surface electromyography (sEMG) to provide biofeedback on submental muscles activity during exercise. An automated swallow-detection algorithm was developed for Mobili-T. Read More

PLoS One 2017 19;12(9):e0184201. Epub 2017 Sep 19.

Department of Medical Biosciences, Umeå University, Umeå, Sweden.

Squamous cell carcinoma of the head and neck (SCCHN) comprises a large group of cancers in the oral cavity and nasopharyngeal area that typically arise in older males in association with alcohol/tobacco usage. Within the oral cavity, the mobile tongue is the most common site for tumour development. The incidence of tongue squamous cell carcinoma (TSCC) is increasing in younger people, which has been suggested to associate with a viral aetiology. Read More

Acta Otolaryngol 2017 Oct 2;137(10):1121-1126. Epub 2017 Jul 2.

b Department of Pathology , Saitama Medical University International Medical Center , Hidaka , Saitama , Japan.

Objectives: The objectives were to determine the prevalence of human papillomavirus (HPV) in mobile tongue cancer (MTC) and evaluate associations and survival.

Materials And Methods: Patients who underwent surgical resection as primary treatment for MTC (n = 127) were retrospectively evaluated. Formalin-fixed paraffin-embedded (FFPE) specimens were assessed for p16 and p53 by immunohistochemistry; for HPV DNA by nested multiplex polymerase chain reaction (PCR) using two pairs of consensus primers (MY09-MY11 and GP5+-GP6+); and for E6 and E7 oncogenes from 13 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 52, 56, 58, 59, 66, and 68) by real-time reverse transcription PCR (RT-PCR). Read More

Eur J Cancer 2017 09 24;82:115-127. Epub 2017 Jun 24.

Department of Oral and Maxillofacial Surgery and Oral Pathology, VU University Medical Center/Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands. Electronic address:

Head and neck squamous cell carcinoma (HNSCC) is typically regarded as a disease of elderly people. However, increasing numbers of patients worldwide with HNSCC at younger age (defined as <45 years old) have been reported in recent years. To assess geographical variations and trends worldwide in incidence of oral and oropharyngeal cancer in young patients, a systematic review was conducted in PubMed and Google scholar databases from 1975 to June 2016. Read More

Phys Med 2017 Sep 28;41:13-19. Epub 2017 Apr 28.

Medical Physics Laboratory, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: To investigate the biological significance of introducing time-resolved dose rate distributions (TR-DRD) in brachytherapy.

Materials And Methods: The treatment plan of a head and neck patient treated with pulsed-dose-rate (PDR) brachytherapy was considered. The TR-DRD was calculated on the basis of a Monte Carlo generated single source dose rate matrix taking into account the dose rate per source dwell position. Read More

J Oral Pathol Med 2017 Nov 9;46(10):967-971. Epub 2017 May 9.

Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.

Background: c-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. Read More

Acta Otolaryngol 2017 Aug 30;137(8):877-882. Epub 2017 Mar 30.

a Department of Surgical Science , Uppsala University , Uppsala , Sweden.

Objective: To investigate whether the extent of expression of hyaluronan (HA) and epidermal growth factor receptor (EGFR) in squamous cell carcinoma of the mobile tongue can predict the risk of cervical metastasis and survival.

Study Design: Retrospective histopathologic study.

Methods: Surgical specimens from 64 patients who had undergone surgery for squamous cell carcinoma of the mobile tongue were assessed using immunohistochemistry to investigate the expression of HA and EGFR in the primary tumours, and the data were then correlated to cervical metastasis and survival. Read More

Anticancer Res 2017 03;37(3):1313-1319

Department of Pathology, Curie Institute, Paris, France.

Background/aim: The focal adhesion kinase (FAK)/SRC phosphorylation cascade and its downstream target paxillin have been implicated in malignant transformation, tumor growth and progression, together with metastasis. The present study aimed to evaluate the clinical significance of concomitant FAK/SRC and p-paxillin expression in mobile tongue squamous cell carcinoma (SCC).

Materials And Methods: FAK, SRC and phospho-paxillin expression in 48 mobile tongue SCC tissue samples was assessed immunohistochemically and analyzed with respect to clinicopathological characteristics and patient survival. Read More

Head Neck Pathol 2017 Mar 28;11(1):33-40. Epub 2017 Feb 28.

Emory University School of Medicine, Atlanta Oral Pathology, 2701 N. Decatur Road, Decatur, GA, 30033, USA.

There have been several additions and deletions in Chapter 4 on Tumours of the oral cavity and mobile tongue in the 2017 fourth edition of the World Health Organization Classification of Tumours of the Head and Neck. This chapter excludes the oropharynx, which now is a stand-alone chapter acknowledging the uniqueness of the oropharynx from the oral cavity. New entries in Chapter 4 include rhabdomyoma, haemangioma, schwannoma, neurofibroma and myofibroblastic sarcoma in the section titled Soft tissue and neural tumours. Read More

Head Neck Pathol 2017 Mar 28;11(1):68-77. Epub 2017 Feb 28.

Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.

The 4th edition of the World Health Organization's Classification of Head and Neck Tumours was published in January of 2017. This article provides a summary of the changes to Chapter 4 Tumours of the oral cavity and mobile tongue and Chapter 8 Odontogenic and maxillofacial bone tumours. Odontogenic cysts which were eliminated from the 3rd 2005 edition were included in the 4th edition as well as other unique allied conditons of the jaws. Read More

J Craniomaxillofac Surg 2017 Apr 25;45(4):589-594. Epub 2017 Jan 25.

Department of Oral Maxillofacial-Head Neck Oncology, Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology (Head: Pro. Chenping Zhang), 639 Zhizaoju Road, Luwan District, Shanghai 200011, PR China.

Purpose: Primary tongue adenoid cystic carcinoma (ACC) is extremely rare. The relationship between the patient's prognosis and the tumor's clinicopathological characteristics is uncertain. The aim of this study was to identify the prognostic factors and analyze the overall outcomes for patients with tongue ACC. Read More

Med Oral Patol Oral Cir Bucal 2016 Nov 1;21(6):e658-e664. Epub 2016 Nov 1.

Departamento de Medicina y Cirugía Bucofacial, Facultad de Odontología, Universidad Complutense de Madrid, Avda. Ramón y Cajal s/n, 28040 Madrid, Spain,

Background: The cancer which appears in the mobile portion of the tongue is the most common neoplasm of the oral cavity. The objective of this study was to analyse oral tongue cancer epidemiology in a population of 610 patients diagnosed between 1990 and 2008 and detailed in the Tumour Registry of the Madrid region.

Material And Methods: A retrospective analysis based on the following variables provided in the Tumour Registry was achieved: age, gender, histology, stage, location, treatment. Read More

J Oral Maxillofac Surg 2017 Mar 27;75(3):632-640. Epub 2016 Aug 27.

Senior Researcher, Department of Pathology, Institute Curie, Paris, France.

Purpose: Phosphorylated epidermal growth factor receptor (pEGFR) activates several signaling pathways, resulting in tumor-promoting cellular activities, and has been implicated in malignant transformation and disease progression. The present study evaluated the clinical significance of pEGFR protein expression in mobile tongue squamous cell carcinoma (SCC).

Materials And Methods: The present cohort study included 48 patients with mobile tongue SCC. Read More

Gen Dent 2016 Sep-Oct;64(5):25-9

Vascular anomalies such as hemangiomas or vascular malformations can produce negative esthetic effects in the maxillofacial region. These negative effects are the main complaints of patients. The clinical therapeutic efficacy of cryotherapy and sclerotherapy in the treatment of these lesions was evaluated in 10 patients who were clinically diagnosed with vascular lesions. Read More

JAMA Otolaryngol Head Neck Surg 2016 09;142(9):857-65

Department of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv, Israel.

Importance: The elective management of no clinical or radiologic evidence of lymph node metastasis in the neck (cN0) in early stage T1-T2 oral tongue squamous cell carcinoma (OTSCC) has been the subject of much debate during the past 3 decades and continues to be controversial.

Objective: To systematically review the literature and carry out a meta-analysis of studies that compared elective neck dissection (END) with observation in patients with early-stage T1-T2 OTSCC and cN0 neck.

Data Sources: The MEDLINE, Scopus, Google scholar, and Cochrane databases were systematically searched for articles published between January 1, 1970, and June 1, 2015. Read More

J Robot Surg 2016 Dec 20;10(4):347-352. Epub 2016 Jun 20.

Department of Otolaryngology-Head and Neck Surgery, James P. Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Ave, Box 629, Rochester, NY, 14642, USA.

This study describes a novel exposure technique for base of tongue trans-oral robotic surgery (BOT TORS) and early experience with it. The technique discussed involves placement of a suture through the mobile tongue with distraction and suspension of the tongue to the operating table. TORS is then performed per previously described techniques. Read More

PLoS One 2016 29;11(4):e0154226. Epub 2016 Apr 29.

Department of Oral and Maxillofacial Radiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.

Purpose: To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients.

Methods: First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations. Read More

Cancer Radiother 2016 Apr 8;20(2):91-7. Epub 2016 Mar 8.

Département de radiothérapie, Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France.

Purpose: Squamous cell carcinomas of the oral cavity occurring in young people represent a specific entity. Its management and prognosis are controversial. We performed a retrospective chart review of all patients aged less than 40 years old and treated at Gustave-Roussy Cancer Centre for a squamous cell carcinomas of the oral cavity between 1999 and 2011. Read More

Stomatologija 2015 ;17(2):67-72

Department of cytopathology, Regional Hospital of Chania, Crete, Greece.

Background: Lesions of the tongue have a broad differential diagnosis ranging from benign idiopathic processes to infections, cancers, and infiltrative disorders. An important thing to remember is that most tongue lesions will resolve spontaneously or with simple therapy within a week, if not, they should be biopsied or evaluated further for a definitive diagnosis of a potentially serious disorder. Some tongue lesions may be clues to other underlying illnesses which require further evaluation Tongue lesions are traditionally evaluated by surgical biopsy. Read More

Radiother Oncol 2016 07 9;120(1):92-7. Epub 2016 Feb 9.

Medical Physics Laboratory, Medical School, National and Kapodistrian University of Athens, Greece. Electronic address:

Purpose: To study the effect of finite patient dimensions and tissue heterogeneities in head and neck high dose rate brachytherapy.

Methods And Materials: The current practice of TG-43 dosimetry was compared to patient specific dosimetry obtained using Monte Carlo simulation for a sample of 22 patient plans. The dose distributions were compared in terms of percentage dose differences as well as differences in dose volume histogram and radiobiological indices for the target and organs at risk (mandible, parotids, skin, and spinal cord). Read More

J Craniofac Surg 2015 Oct;26(7):e622-4

*Department of Stomatology and Maxillofacial Surgery, Gunma University Graduate School of Medicine, Kobe †Department of Plastic Surgery, Kobe University Graduate School of Medicine, Gunma, Japan.

The double free flap procedure is a preferred treatment for extensive composite defects of the oromandibular area. In this procedure, the choice and use of the flaps are both important. Flaps with adequate soft tissue are required to fill the extensive dead space for huge oromandibular defects. Read More

Tumour Biol 2016 Mar 12;37(3):3647-56. Epub 2015 Oct 12.

Department of Pathology, Institut Curie, Paris, France.

Cannabinoid receptors (CB1R and CB2R) constitute essential members of the endocannabinoid system (ECS) which participates in many different functions indispensable to homeostatic regulation in several tissues, exerting also antitumorigenic effects. The present study aimed to assess the clinical significance of CB1R and CB2R protein expression in mobile tongue squamous cell carcinoma (SCC). CB1R and CB2R expression was assessed immunohistochemically on 28 mobile tongue SCC tissue samples and was analyzed in relation with clinicopathological characteristics and overall and disease-free patients' survival. Read More

World J Surg Oncol 2015 Aug 28;13:263. Epub 2015 Aug 28.

Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.

Background: Reports of synchronous multiple primary cancers in patients with oral cancer have recently been increasing because of progress in radiographic diagnostic techniques. Multiple primary cancers in patients with oral cavity cancer mainly occur in the head and neck region, lung, and esophagus. 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography is usually used to identify synchronous multiple primary cancers. Read More

Anticancer Res 2015 Jul;35(7):4235-41

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea Sheikh Khalifa Specialty Hospital, Ras Al Khaimah, United Arab Emirates

Aim: The goal of the present study was to evaluate the effects of celecoxib on treatment outcomes of squamous cell carcinoma of the mobile tongue.

Patients And Methods: Among 158 patients who were diagnosed with mobile tongue cancer, 19 received celecoxib during the preoperative, postoperative, or post-recurrence phase. Differences in disease-specific survival (DSS) and recurrence-free survival (RFS) between patients who received celecoxib (study group) and those who did not (control group) were analyzed. Read More

Br J Cancer 2015 Jul 9;113(2):321-6. Epub 2015 Jun 9.

Department of Medical Biosciences, Umeå University, Umeå SE-901 85, Sweden.

Background: Tongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased.

Methods: Samples from 109 patients with primary TSCC were analysed for the presence of HPV16 by in situ hybridisation and for expression of its surrogate marker p16 and the HPV receptor syndecan-1 by immunhistochemistry. Read More

J Med Life 2015 Jan-Mar;8(1):64-7

Clinic of Plastic Surgery and Reconstructive Microsurgery, Bucharest Emergency Hospital, Bucharest, Romania ; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Background: Successful tongue reconstruction after total glossectomy for advanced tongue or base of tongue cancer should restore swallowing, speech function, and cosmesis.

Methods: The anterior lateral thigh flap sensitive myocutaneous (ALTF) with vastus lateralis muscle was used to reconstruct the oral defect in a patient undergoing total glossectomy with laryngeal preservation for T4 tongue cancer.

Results: Good functional outcomes, measured by independent feeding, speech and swallowing, were achieved. Read More

Stomatologiia (Mosk) 2015 ;94(1):25-29

Tverskaia gosudarstvennaia meditsinskaia akademiia Minzdrava Rossii, Tver'.

After the supervision over patients with cancer of mucous membrane of oral cavity (MMOC) admitted for treatment in the Tver Regional Clinical Oncological Hospital (TRCOH), the analysis of 427 primary revealed cases of cancer of mobile part of the tongue MPoT (S 02) was carried out. The study included retrospective analysis of case records of 237 patients treated from 1997 to 2013 with the diagnosis of MPoT and prospective examination of 190 patients treated by authors in specialized departments of TRCOH. On the basis of questioning of 67 III-IV stages tongue carcinoma patients at the age of 50-59 years clinical course features, cancer risk factors and oral care patterns were studied. Read More

J Craniofac Surg 2015 Jan;26(1):44-7

From the Departments of *Oral, Maxillofacial Surgery and †Plastic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Previous studies on postoperative long-term results in patients who underwent reconstructive free flap transfer following hemiglossectomy had some issues, including the heterogeneity of the patient population and the observation period. The present study aimed to evaluate changes of reconstructed tongues in patients who underwent radial forearm free flap (RFFF) after hemiglossectomy with long-term follow-up. We enrolled 23 patients who underwent RFFF after hemiglossectomy with a postoperative follow-up of 5 years or more. Read More

Brachytherapy 2015 Jan-Feb;14(1):71-6. Epub 2014 Nov 6.

Department of Radiation Oncology, Institut de Cancérologie de l'Ouest, St Herblain, France.

Purpose: To evaluate the efficiency and toxicity of postoperative brachytherapy (POBT) in the treatment of resectable mobile tongue squamous cell carcinoma.

Patients And Methods: This was a retrospective single-center study of patients with SSC of the mobile tongue who were treated between August 1992 and June 2013 by glossectomy and neck dissection followed by (192)Ir interstitial brachytherapy of the tumor bed. Endpoints were local control, cancer-specific survival (CSS), overall survival (OS), and morbidity. Read More

J Oral Pathol Med 2015 Sep 23;44(8):571-7. Epub 2014 Oct 23.

Medical Research Center Oulu, Oulu, Finland.

Background: Toll-like receptor 9 (TLR9) is a cellular receptor, which recognizes bacterial and host-derived DNA. Stimulation of TLR9 induces cellular invasion via matrix metalloproteinase 13 (MMP-13). The aim of this study was to evaluate the role of TLR9 in invasion of oral tongue squamous cell carcinoma (OTSCC). Read More

Int J Mol Sci 2014 Oct 17;15(10):18725-41. Epub 2014 Oct 17.

Department of Physiology, School of Medicine with the Division of Dentistry, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland.

Alcohol increases the risk of carcinoma originated from oral epithelium, but the biological effects of ultra-low doses of ethanol on existing carcinoma cells in combination with natural substances are still unclear. A role for ethanol (EtOH), taken in small amounts as an ingredient of some beverages or mouthwashes to change the growth behavior of established squamous cell carcinoma, has still not been examined sufficiently. We designed an in vitro study to determine the effect of caffeic acid (CFA) on viability and migration ability of malignant oral epithelial keratinocytes, exposed to ultra-low concentrations (maximum 100 mmol/L) EtOH. Read More

Refuat Hapeh Vehashinayim (1993) 2014 Apr;31(2):8-13, 84

Head and neck squamous cell carcinoma (HNSCC), the eighth most common cancer worldwide, accounts for approximately 600,000 new cases per year. The mobile tongue is the most common site for oral cancer and is associated with a poorer survival than other HNSCC sites. Standard therapeutic strategies have failed to significantly improve survival rates that have remained around 50% over the past four decades. Read More

Auris Nasus Larynx 2014 Dec 29;41(6):563-7. Epub 2014 Aug 29.

Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Japan.

Objective: Assessment of tongue function following tongue reconstruction is important to evaluate patient status. To assess tongue function in patients who had undergone tongue reconstruction, the surgical team used a simple, hand-held tongue pressure measurement device to measure tongue power.

Methods: Tongue power of 30 patients (25 males, 5 females; average age: 53. Read More

BMC Oral Health 2014 Aug 18;14:103. Epub 2014 Aug 18.

Department of Medical Biology - Tumour Biology Research Group, UiT The Arctic University of Norway, Tromsø, Norway.

Background: The main aim of the study was to evaluate if patients with oral squamous carcinomas in Northern Norway differ from patients in other countries with regard to clinicopathological characteristics and also study the influence of risk factors. Such a comparison is of demographical interest, and also important for the interpretation of result from studies on prognostic biomarkers.

Methods: We describe clinicopathological characteristics of 133 North Norwegian patients diagnosed with squamous cell carcinoma of the oral cavity in the period 1986-2002, and evaluate the significance of different risk factors. Read More

Br J Oral Maxillofac Surg 2014 Oct 1;52(8):761-3. Epub 2014 Jul 1.

Hospices civils de Lyon, Service ORL, Chirurgie cervico faciale, CHU Lyon Sud, Chemin du Grand Revoyet, 69495 Pierre Bénite, France.

Gustatory sweating (or chorda tympani syndrome) in the submandibular region is a rare complication of cervical surgery. We report a 66-year-old patient who had been referred for the management of a squamous cell carcinoma of the mobile tongue. She was treated by bilateral neck dissection and bilateral resection of the submandibular glands. Read More

J Oral Rehabil 2014 Oct 10;41(10):754-8. Epub 2014 Jun 10.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea.

There have been limited studies of subjective tongue function over long-term follow-up in spite of swallowing and articulation disorders are common complications of glossectomy. To assess long-term subjective swallowing and articulation function after partial glossectomy. A total of 63 patients with the mobile tongue cancer who underwent partial glossectomy without reconstruction were interviewed to score their swallowing and articulation function on a 100-point scale. Read More

Tumour Biol 2014 Jul 30;35(7):6455-65. Epub 2014 Mar 30.

Department of Pathology, Institut Curie, Paris, France,

Extracellular signal-regulated kinase (ERK) has been considered as a critical regulator of diverse cellular processes such as proliferation, survival and motility, being implicated in the malignant transformation in several tissue types. The present study aimed to evaluate the clinical significance of total ERK1 (t-ERK1) and phosphorylated ERK1/2 (p-ERK1/2) protein expression in mobile tongue squamous cell carcinoma (SCC). t-ERK1 and p-ERK1/2 protein expression in tumour cells and infiltrating the tumour microenvironment lymphoid cells was assessed immunohistochemically on 47 mobile tongue SCC tissue samples and was analyzed in relation with clinicopathological characteristics, overall and disease-free patients' survival. Read More

Int J Oral Maxillofac Surg 2014 Jul 28;43(7):795-801. Epub 2014 Feb 28.

Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil. Electronic address:

Although several histopathological parameters and grading systems have been described as predictive of the treatment response and outcome of oral squamous cell carcinoma (OSCC), none is universally accepted. A new scoring system, the histological risk model, was recently described to be a powerful predictive tool for recurrence and overall survival in OSCC. The aim of this study was to verify the predictive role of the histological risk model in a cohort of 202 patients at all stages of oral/mobile tongue squamous cell carcinoma (OTSCC). Read More

Laryngoscope 2014 Jun 18;124(6):1336-43. Epub 2013 Dec 18.

Department of Plastic and Reconstructive Surgery, Institut Gustave Roussy, 94805, Villejuif Cedex, France.

Objectives/hypothesis: The purpose of this study was to analyze our experience with the composed double skin paddle fibula free flap to reconstruct large mandibulofacial defects.

Study Design: Between 2006 and 2011, a total of 32 composed double skin paddle fibula free flap procedures were performed on 32 patients (mean age 54.4 ± 9. Read More

Pathol Oncol Res 2014 Apr 11;20(2):277-84. Epub 2013 Sep 11.

Department of Pathology, Institut Curie, Paris, France,

Ephrin receptors (Ephs) are frequently overexpressed in a wide variety of human malignant tumors, being associated with tumor growth, invasion, metastasis and angiogenesis. The present study aimed to evaluate the clinical significance of Eph-A1, -A2, -A4 and -A7 protein expression in mobile tongue squamous cell carcinoma (SCC). Eph-A1, -A2, -A4 and -A7 protein expression was assessed immunohistochemically on 37 mobile tongue SCC tissue samples and was analyzed in relation with clinicopathological characteristics, overall and disease-free patients' survival. Read More

Plast Reconstr Surg 2013 Sep;132(3):656-65

Plastic Surgery Unit , Sant'Andrea Hospital, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.

Background: Reconstruction of a functional tongue with proper motility and sensation after subtotal resection is a demanding procedure. The authors describe the reinnervated mushroom-shaped anterolateral thigh perforator flap for subtotal tongue reconstruction.

Methods: Thirteen patients (mean age, 54. Read More

PLoS One 2013 7;8(8):e70925. Epub 2013 Aug 7.

Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland.

Objectives: Cathepsin K, a lysosomal cysteine protease, is expressed in the tumor microenvironment (TME) of skin carcinoma, but nothing is known about cathepsin K in oral tongue squamous cell carcinoma (OTSCC). Our aim was to describe the expression of cathepsin K in invasive OTSCC in vitro and in a series of clinical cancer specimens.

Materials And Methods: OTSCC invasion in vitro was studied using invasive HSC-3 tongue carcinoma cells in 3D organotypic models. Read More

Jpn J Clin Oncol 2013 Oct 1;43(10):1012-7. Epub 2013 Aug 1.

*Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objectives: The aim of the study was to investigate the outcomes of high-dose-rate interstitial radiation therapy for patients with Stage I and II mobile tongue cancer retrospectively.

Methods: Sixty-seven patients with Stage I and II mobile tongue cancer were treated with high-dose-rate interstitial radiation therapy, with or without external beam radiation therapy, between 1997 and 2007. The median dose of interstitial radiation therapy was 50 Gy in 10 fractions over 6 days. Read More

J Plast Reconstr Aesthet Surg 2013 Nov 21;66(11):1464-9. Epub 2013 Jul 21.

Plastic Surgery Unit, Sant'Andrea Hospital, NESMOS Department, School of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.

Introduction: Combined hemiglossectomy and floor-of-the-mouth defects need accurate reconstructive planning to restore swallowing and speech function. The aim of this prospective study was to evaluate outcomes of the bilobed design applied to perforator free flaps for combined hemitongue and floor-of-the-mouth defects.

Patients And Methods: Twelve patients with a mean age of 71 years (range, 60-84) addressed to combined hemiglossectomy and floor-of-the-mouth resection and bilobed-shaped perforator free-flap reconstruction were prospectively enrolled. Read More