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BMJ Case Rep 2020 Oct 30;13(10). Epub 2020 Oct 30.

Radiology Department, Instituto Português de Oncologia Lisboa Francisco Gentil, Lisboa, Portugal

Mucinous cystadenocarcinoma of minor salivary glands is an extremely rare entity that has only recently been described, with a few published cases in the English literature. A 42-year-old woman with a history of a surgically excised mucinous cystadenoma of the oral tongue, presented with a painful swelling in the oral tongue slowly growing for 1 month. On clinical examination, there was a firm, relatively well-circumscribed mass in the left posterior border of the mobile tongue. Read More

J Med Internet Res 2020 10 26;22(10):e21238. Epub 2020 Oct 26.

Department of Communication Science, Amsterdam School of Communication Research/ASCoR, University of Amsterdam, Amsterdam, Netherlands.

Background: Older migrant patients with cancer face many language- and culture-related barriers to patient participation during medical consultations. To bridge these barriers, an eHealth tool called Health Communicator was developed in the Netherlands. Essentially used as a digital translator that can collect medical history information from patients, the Health Communicator did not include an oncological module so far, despite the fact that the prevalence of Dutch migrant patients with cancer is rising. Read More

Virchows Arch 2020 Dec 30;477(6):865-872. Epub 2020 Jun 30.

Department of Medical Biology, UiT The Arctic University of Norway, Tromsø, Norway.

We wanted to evaluate the prognostic value of common histopathological variables in a large cohort of patients with cancer in the mobile tongue as such information can be important for treatment stratification of the individual patient, especially for patients with low-stage disease. In addition, we wanted to investigate whether an alternative scoring model with fewer options would compromise the prognostic value. One hundred fifty patients with oral tongue squamous cell carcinomas that were treated in curative intent and with available HE-stained tumor sections were included. Read More

J Formos Med Assoc 2021 Jan 3;120(1 Pt 2):361-370. Epub 2020 Jun 3.

Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Oral & Maxillofacial Imaging Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Oral & Maxillofacial Surgery, Kaohsiung Medical University Hospital Kaohsiung, Taiwan. Electronic address:

Background/purpose: Due to the rarity of oral lymphoma (OL), we aimed to evaluate the clinical features of OL and discuss these findings in light of the literature.

Methods: English language literature (1980-2019) related to OL was searched in two electronic databases. Patients (2000-2019) diagnosed with OL were also selected from the database of the Oral Pathology Department in our institution. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Feb;52(1):30-34

Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To investigate the incidence and clinicopathologic features of cervical lymph node metastasis in salivary gland adenoid cystic carcinoma (AdCC).

Methods: Retrospective analysis was made in 798 AdCC patients who underwent tumor resection during January, 2001 to January, 2019 in Peking University School and Hospital of Stomatology, especially the clincopathologic characteristics of 82 cases with lymph node metastasis.

Results: In the study, 82 of the 798 patients were identified with cervical lymph node metastasis, which was confirmed by histopathological examination. Read More

J Biomed Opt 2019 10;24(10):1-8

The University of Arizona, College of Optical Sciences, Tucson, Arizona, United States.

Oral cancer is a growing health issue in low- and middle-income countries due to betel quid, tobacco, and alcohol use and in younger populations of middle- and high-income communities due to the prevalence of human papillomavirus. The described point-of-care, smartphone-based intraoral probe enables autofluorescence imaging and polarized white light imaging in a compact geometry through the use of a USB-connected camera module. The small size and flexible imaging head improves on previous intraoral probe designs and allows imaging the cheek pockets, tonsils, and base of tongue, the areas of greatest risk for both causes of oral cancer. Read More

Pan Afr Med J 2018 22;31:199. Epub 2018 Nov 22.

Service de Médecine Interne B, Hôpital Charles Nicolle, Université de Tunis El Manar, Faculté de Médecine de Tunis, Tunisie.

The diagnosis of granuloma of the oral cavity can favour the detection of several diseases such as sarcoidosis, Crohn's disease, tuberculosis, syphilis and malignant tumors. In Melkerson Rosenthal syndrome it has an idiopathic origin. In this regard, we here report an original case of idiopathic granuloma of the tongue not secondary to Melkerson Rosenthal syndrome and being part of benign tumors of the oral cavity. Read More

Medicine (Baltimore) 2019 Apr;98(16):e15250

Department of Head and Neck Cancer Center.

Rationale: Adenoid cystic carcinoma (ACC) is an infrequent malignant neoplasm of the salivary glands. The clinical and pathological characteristics include slow growth, perineural invasion, and local recurrence. ACC of the mobile tongue is rarely reported in the literature. Read More

J Contemp Brachytherapy 2019 Feb 28;11(1):28-34. Epub 2019 Feb 28.

Department of Radiation Oncology, Peking University Third Hospital, Beijing.

Purpose: The aim of this study was to evaluate the efficacy and safety of interstitial permanent low-dose-rate ultrasound-guided I seeds implantation of local head and neck recurrent tumors.

Material And Methods: Sixty-four consecutive patients, with 81 lesions in total, underwent permanent implantation of I seeds under ultrasound guidance. Post-operative dosimetry was performed for all patients. Read More

Int J Oral Maxillofac Surg 2019 Jul 7;48(7):851-856. Epub 2019 Feb 7.

Department of Cranio-Maxillo-Facial and Oral Surgery, University Hospital of Zurich, Zurich, Switzerland.

This study was performed to report the outcomes of patients with oral squamous cell carcinoma (OSCC) of the tongue over a 10-year period with the aim of testing the hypothesis that the lymph node ratio (LNR) has a significant influence on loco-regional recurrence. The charts of 227 patients with OSCC of the mobile tongue treated at the University Hospital of Zurich from 2003 to 2012 were screened. Following the application of the exclusion criteria (prior chemotherapy, radiotherapy, or surgery, perioperative death, N3 disease, unresectable disease, synchronous second primary, no signed informed consent, and follow-up <3years), prospective data were collected and a retrospective analysis performed for 88 of these patients who were treated with selective neck dissection. Read More

Braz Oral Res 2018 Dec 6;32:e123. Epub 2018 Dec 6.

Hospital General de México "Eduardo Liceaga", Department of Pathology, México City, México.

This study aims to evaluate the clinicopathological features, TNM status, AJCC staging and behavior of squamous cell carcinoma of the tongue (SCCT) in patients older than 45 years. The files of the Department of Pathology of the Hospital General de México were reviewed and all cases of SCCT in patients older than 45 years were selected. Clinicopathological features, treatment, follow-up, microscopic diagnosis, and IJCC and TNM staging were retrieved. Read More

Radiol Oncol 2018 11 12;52(4):461-467. Epub 2018 Nov 12.

Center of Radiotherapy, National Institute of Oncology, Budapest, Hungary.

Background The aim of the study was to present dosimetric comparison of image guided high-dose-rate brachytherapy (IGBT) with volumetric modulated arc therapy (VMAT) for head and neck cancer regarding conformity of dose distribution to planning target volume (PTV) and doses to organs at risk (OARs). Patients and methods Thirty-eight consecutive patients with T1-4 mobile tongue, floor of mouth and base of tongue cancer treated with IGBT were selected. For these patients additional VMAT treatment plans were also prepared using identical computed tomography data. Read More

Ann Chir Plast Esthet 2019 Feb 24;64(1):98-105. Epub 2018 Sep 24.

Institut Gustave-Roussy, department of plastic surgery, Gustave-Roussy, 114 rue Édouard-Vaillant, 94805 Villejuif, France.

Clear cell sarcomas (SCC), also called "soft-tissue melanoma", are rare and aggressive tumors that preferentially affect the lower limbs (tendons and fasciae) and which have also been described in head and neck localizations. Their clinical and immunohistochemical mimicry with melanoma makes it difficult to diagnose sarcomas. SCC treatment is mainly focused on large-scale resection surgery with adjuvant radiotherapy because of their low chemo-sensitivity and extreme lymphophilia. Read More

Yale J Biol Med 2018 09 21;91(3):215-223. Epub 2018 Sep 21.

Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, UCLA, Los Angeles, CA.

Oral and head and neck squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide. The primary management of OSCC relies on complete surgical resection of the tumor. Margin-free resection, however, is difficult given the devastating effects of aggressive surgery. Read More

Acta Otorhinolaryngol Ital 2018 Jun;38(3):175-180

Department of Otolaryngology, Head and Neck Surgery, Fondazione IRCCS, Istituto Nazionale dei Tumori di Milano, University of Milan, Italy.

Summary: A recent reduction in the number of smoke-related tumours has been observed thanks to the diffusion of anti-tobacco campaigns carried out in the majority of developed countries. Nevertheless, as demonstrated by recent global epidemiologic studies, squamous cell carcinoma of the mobile tongue appears to be progressively increasing in incidence, particularly among young adults and especially in females. The driving mechanism responsible for such changes is still to be precisely defined. Read More

J Oral Pathol Med 2018 Sep 27;47(8):764-772. Epub 2018 May 27.

Research Program Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland.

Background: Certain periodontopathogenic bacteria have been linked to cancers. Treponema denticola (Td) is associated with severe periodontitis. Chymotrypsin-like proteinase (CTLP), a major virulence factor of Td, can degrade various host proteins and peptides, and modulate inflammatory responses. Read More

Br Dent J 2018 04 20;224(8):611-9. Epub 2018 Apr 20.

Consultant in Restorative Dentistry, Central Manchester University Teaching Hospitals NHS Foundation Trust, Manchester, M15 6FH.

Surgical resection of an oral tumour (and the associated free flap reconstruction) can significantly alter the oral anatomy. The lack of sulcus depth, alveolar ridge, presence of a mobile flap and limited tongue movement can make it impossible for patients to control a removable prosthesis. To help this cohort of patients, dental implants can be invaluable. Read More

J Surg Oncol 2018 Apr 12;117(5):1092-1099. Epub 2018 Feb 12.

Maxillo-Facial Surgery Unit, AOU-Careggi, Florence, Italy.

Background And Objectives: Reconstruction of tongue cancer defects is challenging due to the complex anatomy and physiology of the tongue. Here, we classify patterns of tongue tissue loss and describe a treatment algorithm for achieving good functional and oncologic outcomes.

Methods: We retrospectively reviewed 50 tongue squamous-cell carcinomas surgically treated between January 2010-June 2015. Read More

Dysphagia 2018 06 2;33(3):345-357. Epub 2017 Nov 2.

Department of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine, University of Alberta, 8205 114St 2-70 Corbett Hall, Edmonton, AB, T6R 3T5, Canada.

Mobile health (mHealth) technologies may offer an opportunity to address longstanding clinical challenges, such as access and adherence to swallowing therapy. Mobili-T is an mHealth device that uses surface electromyography (sEMG) to provide biofeedback on submental muscles activity during exercise. An automated swallow-detection algorithm was developed for Mobili-T. Read More

PLoS One 2017 19;12(9):e0184201. Epub 2017 Sep 19.

Department of Medical Biosciences, Umeå University, Umeå, Sweden.

Squamous cell carcinoma of the head and neck (SCCHN) comprises a large group of cancers in the oral cavity and nasopharyngeal area that typically arise in older males in association with alcohol/tobacco usage. Within the oral cavity, the mobile tongue is the most common site for tumour development. The incidence of tongue squamous cell carcinoma (TSCC) is increasing in younger people, which has been suggested to associate with a viral aetiology. Read More

Acta Otolaryngol 2017 Oct 2;137(10):1121-1126. Epub 2017 Jul 2.

b Department of Pathology , Saitama Medical University International Medical Center , Hidaka , Saitama , Japan.

Objectives: The objectives were to determine the prevalence of human papillomavirus (HPV) in mobile tongue cancer (MTC) and evaluate associations and survival.

Materials And Methods: Patients who underwent surgical resection as primary treatment for MTC (n = 127) were retrospectively evaluated. Formalin-fixed paraffin-embedded (FFPE) specimens were assessed for p16 and p53 by immunohistochemistry; for HPV DNA by nested multiplex polymerase chain reaction (PCR) using two pairs of consensus primers (MY09-MY11 and GP5+-GP6+); and for E6 and E7 oncogenes from 13 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 52, 56, 58, 59, 66, and 68) by real-time reverse transcription PCR (RT-PCR). Read More

Eur J Cancer 2017 09 24;82:115-127. Epub 2017 Jun 24.

Department of Oral and Maxillofacial Surgery and Oral Pathology, VU University Medical Center/Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands. Electronic address:

Head and neck squamous cell carcinoma (HNSCC) is typically regarded as a disease of elderly people. However, increasing numbers of patients worldwide with HNSCC at younger age (defined as <45 years old) have been reported in recent years. To assess geographical variations and trends worldwide in incidence of oral and oropharyngeal cancer in young patients, a systematic review was conducted in PubMed and Google scholar databases from 1975 to June 2016. Read More

Phys Med 2017 Sep 28;41:13-19. Epub 2017 Apr 28.

Medical Physics Laboratory, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: To investigate the biological significance of introducing time-resolved dose rate distributions (TR-DRD) in brachytherapy.

Materials And Methods: The treatment plan of a head and neck patient treated with pulsed-dose-rate (PDR) brachytherapy was considered. The TR-DRD was calculated on the basis of a Monte Carlo generated single source dose rate matrix taking into account the dose rate per source dwell position. Read More

J Oral Pathol Med 2017 Nov 9;46(10):967-971. Epub 2017 May 9.

Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.

Background: c-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. Read More

Acta Otolaryngol 2017 Aug 30;137(8):877-882. Epub 2017 Mar 30.

a Department of Surgical Science , Uppsala University , Uppsala , Sweden.

Objective: To investigate whether the extent of expression of hyaluronan (HA) and epidermal growth factor receptor (EGFR) in squamous cell carcinoma of the mobile tongue can predict the risk of cervical metastasis and survival.

Study Design: Retrospective histopathologic study.

Methods: Surgical specimens from 64 patients who had undergone surgery for squamous cell carcinoma of the mobile tongue were assessed using immunohistochemistry to investigate the expression of HA and EGFR in the primary tumours, and the data were then correlated to cervical metastasis and survival. Read More

Anticancer Res 2017 03;37(3):1313-1319

Department of Pathology, Curie Institute, Paris, France.

Background/aim: The focal adhesion kinase (FAK)/SRC phosphorylation cascade and its downstream target paxillin have been implicated in malignant transformation, tumor growth and progression, together with metastasis. The present study aimed to evaluate the clinical significance of concomitant FAK/SRC and p-paxillin expression in mobile tongue squamous cell carcinoma (SCC).

Materials And Methods: FAK, SRC and phospho-paxillin expression in 48 mobile tongue SCC tissue samples was assessed immunohistochemically and analyzed with respect to clinicopathological characteristics and patient survival. Read More

Head Neck Pathol 2017 Mar 28;11(1):33-40. Epub 2017 Feb 28.

Emory University School of Medicine, Atlanta Oral Pathology, 2701 N. Decatur Road, Decatur, GA, 30033, USA.

There have been several additions and deletions in Chapter 4 on Tumours of the oral cavity and mobile tongue in the 2017 fourth edition of the World Health Organization Classification of Tumours of the Head and Neck. This chapter excludes the oropharynx, which now is a stand-alone chapter acknowledging the uniqueness of the oropharynx from the oral cavity. New entries in Chapter 4 include rhabdomyoma, haemangioma, schwannoma, neurofibroma and myofibroblastic sarcoma in the section titled Soft tissue and neural tumours. Read More

Head Neck Pathol 2017 Mar 28;11(1):68-77. Epub 2017 Feb 28.

Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.

The 4th edition of the World Health Organization's Classification of Head and Neck Tumours was published in January of 2017. This article provides a summary of the changes to Chapter 4 Tumours of the oral cavity and mobile tongue and Chapter 8 Odontogenic and maxillofacial bone tumours. Odontogenic cysts which were eliminated from the 3rd 2005 edition were included in the 4th edition as well as other unique allied conditons of the jaws. Read More

J Craniomaxillofac Surg 2017 Apr 25;45(4):589-594. Epub 2017 Jan 25.

Department of Oral Maxillofacial-Head Neck Oncology, Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology (Head: Pro. Chenping Zhang), 639 Zhizaoju Road, Luwan District, Shanghai 200011, PR China.

Purpose: Primary tongue adenoid cystic carcinoma (ACC) is extremely rare. The relationship between the patient's prognosis and the tumor's clinicopathological characteristics is uncertain. The aim of this study was to identify the prognostic factors and analyze the overall outcomes for patients with tongue ACC. Read More

Med Oral Patol Oral Cir Bucal 2016 Nov 1;21(6):e658-e664. Epub 2016 Nov 1.

Departamento de Medicina y Cirugía Bucofacial, Facultad de Odontología, Universidad Complutense de Madrid, Avda. Ramón y Cajal s/n, 28040 Madrid, Spain,

Background: The cancer which appears in the mobile portion of the tongue is the most common neoplasm of the oral cavity. The objective of this study was to analyse oral tongue cancer epidemiology in a population of 610 patients diagnosed between 1990 and 2008 and detailed in the Tumour Registry of the Madrid region.

Material And Methods: A retrospective analysis based on the following variables provided in the Tumour Registry was achieved: age, gender, histology, stage, location, treatment. Read More