21,815 results match your criteria Malignant Tumors of the Larynx


[Clinical features of mucosa-associated lymphoid tissue lymphoma in head and neck].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):362-366

To summarize the clinical features, diagnosis and treatment of mucosa-associated lymphoid tissue(MALT) lymphoma in head and neck. The clinical data of 22 hospitalizedpatients with MALT lymphoma in head and neck during the recent 18 years were analyzed retrospectively. Among the 22 cases, 13 patients showed salivary gland lesions, 4 showed larynx and trachea lesions,3 showed nasopharynx lesions and 2 showed thyroid gland lesions. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.018DOI Listing
April 2019
7 Reads

Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings.

Braz J Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

Erciyes University Medical Faculty, Department of Radiology, Kayseri, Turkey.

Introduction: Squamous cell carcinoma is the most common laryngeal neoplasm and accounts for approximately 95% of all malignant neoplams of the larynx. However, various benign and malignant tumors and inflammatory diseases may affect the larynx.

Objective: The purpose of this study is to analyze the clinical and imaging findings of non-squamous cell neoplasms and inflammatory diseases of the larynx. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18088694183022
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http://dx.doi.org/10.1016/j.bjorl.2019.02.003DOI Listing
March 2019
6 Reads

Comparative efficacy of six therapies for Hypopharyngeal and laryngeal neoplasms: a network meta-analysis.

BMC Cancer 2019 Mar 29;19(1):282. Epub 2019 Mar 29.

Department of Otorhinolaryngology, Binzhou Medical University Hospital, No. 661 Second Huanghe Road, Binzhou, 256603, Shandong, China.

Background: Hypopharyngeal and laryngeal neoplasms are both fatal and hard to catch in early stages. Yet which treatment is the most efficacious one still remain unanswered. This network meta-analysis (NMA) was conducted to investigate effectiveness of six therapies being utilized in clinical practice nowadays. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5412-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439970PMC
March 2019
4 Reads

Chondroma of laryngeal cartilage mimicking thyroid tumor: A case report.

Medicine (Baltimore) 2019 Mar;98(13):e15005

Departments of Otolaryngology-Head and Neck Surgery.

Rationale: Cartilaginous tumors of the larynx are rare. This report describes an atypical case with chondroma of laryngeal cartilage presenting as cervical mass, which was misdiagnosed as a thyroid tumor.

Patient Concern: A 73-year-old Chinese man with a 1-month history of cervical mass. Read More

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http://dx.doi.org/10.1097/MD.0000000000015005DOI Listing
March 2019
1 Read

Second primary lung cancer in United States Cancer Survivors, 1992-2008.

Cancer Causes Control 2019 May 21;30(5):465-475. Epub 2019 Mar 21.

Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Purpose: Lung cancer is common and lethal, and can occur in survivors of previous cancers. We sought to describe the incidence and mortality attributable to second primary lung cancers (SPLC) among survivors of other cancers, and to identify survivors at highest risk.

Methods: We identified adults diagnosed with a localized malignancy from non-pulmonary cancer sites from surveillance, epidemiology, and end results (SEER) data from 1992 to 2008. Read More

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http://dx.doi.org/10.1007/s10552-019-01161-7DOI Listing
May 2019
1 Read

Increased risk of larynx cancer in patients with gastroesophageal reflux disease from a national sample cohort.

Clin Otolaryngol 2019 Mar 18. Epub 2019 Mar 18.

Department of Otorhinolaryngology-Head& Neck Surgery, Hallym University College of Medicine, Anyang, Korea.

Objectives: The present study evaluated the associations between gastroesophageal reflux disease (GERD) and head and neck cancer using a national sample cohort of the Korean population.

Design: We designed two studies using data collected from patients aged ≥ 40 years in the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013.

Main Outcome Measures: Study I included participants with GERD matched 1:2 with controls and analyzed the incidences of lip and oral cavity, oropharynx, hypopharynx, and larynx cancers. Read More

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http://dx.doi.org/10.1111/coa.13328DOI Listing
March 2019
2 Reads

Transient vocal fold lesion and hoarseness associated with the use of ramucirumab: Case report.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 12. Epub 2019 Mar 12.

Department of Medical Oncology, AC Camargo Cancer Center, São Paulo, SP, Brazil.

Introduction: Gastric cancer (GC) is among the leading neoplasms with highest morbidity and mortality in the world. Tumor angiogenesis represents one of important targets of antineoplastic treatment, as it has an important role in cell development and growth.

Case Report: Ramucirumab, an IgG1 monoclonal antibody (MoAb), inhibits the angiogenesis pathway by blocking the VEGFR-2 activation. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.08.017DOI Listing
March 2019
1 Read

Glottic Carcinoma in Young Patients.

Ann Otol Rhinol Laryngol 2019 Mar;128(3_suppl):25S-32S

3 Department of Surgery, Harvard Medical School, Boston, MA, USA.

Introduction:: Recent reported evidence indicates that vocal cord carcinoma is evolving similarly to oropharyngeal cancer with an increasing number of patients without a smoking history having human papillomavirus (HPV) disease. Observations also suggest that an increasing number of patients who present with glottic carcinoma are younger than has been reported in the past. Therefore, an investigation was done to examine the incidence of glottic carcinoma in patients 30 years old (y/o) or younger. Read More

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http://dx.doi.org/10.1177/0003489418818852DOI Listing
March 2019
1 Read

Digital Analysis of BCL2 Expression in Laryngeal Squamous Cell Carcinoma.

Anticancer Res 2019 Mar;39(3):1253-1257

First ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.

Background: Deregulation of apoptosis is critical regarding the development and progression of malignancies, including laryngeal squamous cell carcinoma (LSCC). B-Cell lymphoma 2 (BCL2) (gene locus:18q21.33), located on the outer mitochondrial membrane, acts mainly as an anti-apoptotic factor suppressing and blocking apoptotic signal transduction. Read More

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http://dx.doi.org/10.21873/anticanres.13235DOI Listing
March 2019
4 Reads

[Relationship between morphological characteristics and prognosis of non-nasopharyneal EBV-associated carcinoma].

Zhonghua Bing Li Xue Za Zhi 2019 Mar;48(3):209-214

Department of Pathology, Zhejiang Chinese Medical University Affiliated Zhejiang Cancer Hospital, Hangzhou 310022, China.

To analyze the pathological features and their influence on the clinical outcome of non-nasopharyngeal EBV-associated carcinomas. One hundred and twenty cases of non-nasopharyngeal EBV-associated carcinoma confirmed by in situ hybridization were identified at Zhejiang Cancer Hospital from January 1, 2006 to May 1, 2018, and the clinicopathological data were collected and analyzed using Kaplan-Meier survival analysis, Cox univariate and multivariate analysis. One hundred and twenty cases were involved in the study; the male to female ratio was 1∶1; patients' age range was 24 to 89 years (median 50 years). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.03.008DOI Listing
March 2019
4 Reads

Volumetric modulated arc therapy with robust optimization for larynx cancer.

Phys Med 2019 Feb 25;58:54-58. Epub 2019 Jan 25.

Hiroshima High-Precision Radiotherapy Cancer Center, Hiroshima, Japan; Department of Radiation Oncology, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, Japan.

Purpose: The aim of this study was to perform a comparison between robust optimization and planning target volume (PTV)-based optimization plans using volumetric modulated arc-therapy (VMAT) by evaluating perturbed doses induced by localization offsets for setup uncertainties in larynx cancer radiation therapy.

Methods: Ten patients with early-stage (T1-2N0) glottis carcinoma were selected. The clinical target volume (CTV), carotid arteries, and spinal cord were contoured by a radiation oncologist. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11201797193001
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http://dx.doi.org/10.1016/j.ejmp.2019.01.012DOI Listing
February 2019
6 Reads

[Therapeutic effect of low-temperature radiofrequency coblation on early-stage laryngeal cancer].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;33(2):143-147

Department of Otorhinolaryngology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, China.

To evaluate the safety,efficacy and prognosis of low-temperature plasma radiofrequency coblation for early-stage laryngeal cancer(Tis, T1 and T2). A retrospective analysis of 202 patients with early-stage laryngeal cancer who underwent the low-temperature radiofrequency coblation surgery, including 34 cases of Tis(16.83%), 49 cases of stage T1aN0M0(24. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2019.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.02.012DOI Listing
February 2019
4 Reads

Salvage radiotherapy for recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) after first-line treatment with surgery alone: a 10-year single-centre experience.

Radiat Oncol 2019 Feb 19;14(1):34. Epub 2019 Feb 19.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Purpose: Salvage surgery of recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) results in limited local control and survival rates. As a result of recent technological progress, radiotherapy (RT) has become a valuable, potentially curative therapeutic option. Thus, we aimed to determine prognostic factors for survival outcome in order to optimize patient selection for salvage radiotherapy after failure of first-line treatment with surgery alone in this special patient cohort. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
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http://dx.doi.org/10.1186/s13014-019-1238-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381740PMC
February 2019
4 Reads

A case report of application of posterior pharyngeal flap in resection and reconstruction of posterior pharyngeal wall carcinomas located at the level of the cricoid cartilage.

Medicine (Baltimore) 2019 Feb;98(7):e14412

Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Rationale: posterior pharyngeal wall carcinomas located at the level of the cricoid cartilage is a rare occurrence. Surgical treatment is a dilemma owing to the retention of laryngeal function PATIENT CONCERNS:: A 56-year-old man underwent a "resection of left cervical tumor" at another hospital. Postoperative pathological report noted a left metastatic squamous cell carcinoma of the neck. Read More

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http://dx.doi.org/10.1097/MD.0000000000014412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408051PMC
February 2019
2 Reads

The impact of reducing alcohol consumption in Australia: An estimate of the proportion of potentially avoidable cancers 2013-2037.

Int J Cancer 2019 Feb 12. Epub 2019 Feb 12.

Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.

The International Agency for Research on Cancer first concluded that alcohol causes cancer in humans in 1988. The World Cancer Research Fund has declared that alcohol causes cancer of the oral cavity, pharynx, larynx, oesophagus (squamous cell carcinoma), female breast, colon, rectum, stomach and liver. It recommended that alcohol be avoided altogether to prevent cancer. Read More

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http://dx.doi.org/10.1002/ijc.32204DOI Listing
February 2019
6 Reads

Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy.

Auris Nasus Larynx 2019 Feb 7. Epub 2019 Feb 7.

Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

As has been well recognized, methotrexate (MTX) leads to a state of immunosuppression and can provide a basis for the development of lymphoproliferative disorders (LPDs). MTX-associated LPDs can affect nodal sites as well as extranodal sites, though the manifestation of an LPD in the form of multiple pulmonary nodules is rare. Here, we report two cases of MTX-associated LPD with multiple bilateral pulmonary nodules, which was a finding suggestive of lung cancer, and bilateral cervical lymphadenopathy. Read More

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http://dx.doi.org/10.1016/j.anl.2019.01.010DOI Listing
February 2019
2 Reads

Do CO and oxidative stress induce cancer?: a brief study about the evaluation of PON 1, CAT, CA and XO enzyme levels on head and neck cancer patients.

J Enzyme Inhib Med Chem 2019 Dec;34(1):459-464

c Department of Medical Biology, Faculty of Medicine , Ankara Yildirim Beyazit University, Bilkent Campus , Ankara , Turkey.

Head and neck cancer (HNC) is one of the most common malignancies in the world. HNC is a group of cancers that starts in the mouth, nose, throat, larynx, sinuses, or salivary glands. According to this section of the body parts; induction of cancer can be associated with CO and oxidative stress. Read More

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http://dx.doi.org/10.1080/14756366.2018.1555157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327982PMC
December 2019
4 Reads

Prevalence of Fatigue in Head and Neck Cancer Survivors.

Ann Otol Rhinol Laryngol 2019 May 30;128(5):413-419. Epub 2019 Jan 30.

2 Supportive Care Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Introduction: In head and neck cancer (HNC) patients, fatigue is present throughout the course of treatment and during follow-up. There are limited data about the prevalence and factors associated with fatigue in HNC survivors. The objectives of this study were to assess the prevalence of fatigue and its interference with daily life activities and examine the association between fatigue and gender, age, primary tumour site, Human Papillomavirus (HPV) status, previous oncologic therapy, and time since end of treatment. Read More

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http://dx.doi.org/10.1177/0003489419826138DOI Listing
May 2019
21 Reads
1.054 Impact Factor

Free bipaddled anterolateral thigh flap for simultaneous reconstruction of large larynx and prelaryngeal skin defects after resection of the local recurrent laryngeal cancer invading the cricoid cartilage and prelaryngeal skin: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14199

Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

Rationale: After total or near-total laryngectomy and resection of prelaryngeal skin, laryngeal defects and prelaryngeal skin defects often remain a great challenge for head and neck surgeons when considering simultaneous reconstruction of. In this case report, a free bipaddled anterolateral thigh (ALT) was used for such defects reconstruction.

Patient Concerns: For this 50-year-old male patient whose recurrent tumor invaded the cricoid cartilage and the prelaryngeal skin, supracricoid partial laryngectomy with a cricohyoidepiglottopexy would no longer be an option. Read More

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http://dx.doi.org/10.1097/MD.0000000000014199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358393PMC
January 2019
2 Reads
5.723 Impact Factor

Prevalence of human papillomavirus-related diseases in the Republic of Korea: a cross-sectional study.

Sex Transm Infect 2019 Jan 24. Epub 2019 Jan 24.

Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea

Objective: We aimed to evaluate trends in the prevalence of human papillomavirus (HPV)-related diseases in the era before the introduction of organised HPV vaccination programmes in the Republic of Korea.

Methods: This cross-sectional study used National Health Insurance Service data from 2002 to 2015 and included participants who were diagnosed with the following HPV-related diseases (codes from the International Classification of Diseases, 10th Revision): genital warts (A63.0); cancer in the head and neck (C00-C10), anus (C21), vulva (C51), vagina (C52), cervix uteri (C53) and penis (C60); carcinoma in situ (CIS) of the lip/oral cavity/pharynx (D00. Read More

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http://sti.bmj.com/lookup/doi/10.1136/sextrans-2018-053742
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http://dx.doi.org/10.1136/sextrans-2018-053742DOI Listing
January 2019
11 Reads

Cluster of differentiation 8 T-cell population in the laryngeal mucosa of smokers with laryngeal cancer.

J Laryngol Otol 2018 Dec;132(12):1134-1137

Department of Otolaryngology,Cairo Police Hospital,Egypt.

Objective: To study the cluster of differentiation 8 population in the laryngeal mucosa of patients with laryngeal carcinoma. To our knowledge this is the first paper to address this issue.

Methods: The study group included 40 patients with known laryngeal cancer who were scheduled for laryngectomy. Read More

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http://dx.doi.org/10.1017/S0022215118002244DOI Listing
December 2018

[Primary mucinous adenocarcinoma of the larynx: a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;33(1):80-81

Mucinous adenocarcinoma is most commonly found in the digestive tract,and the prognosis is poor.We present here a case of primary mucinous adenocarcinoma of the larynx, which is an extremely rare entity and very few have been reported in the literature.A 72-year-old male complained of intermittent hoarseness for over 2 months of duration. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.01.017DOI Listing
January 2019
1 Read

Long-term Survival in Head and Neck Cancer: Impact of Site, Stage, Smoking, and Human Papillomavirus Status.

Laryngoscope 2019 Jan 13. Epub 2019 Jan 13.

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri, U.S.A.

Objectives/hypothesis: Literature examining long-term survival in head and neck squamous cell carcinoma (HNSCC) with human papillomavirus (HPV) status is lacking. We compare 10-year overall survival (OS) rates for cases to population-based controls.

Study Design: Prospective cohort study. Read More

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http://doi.wiley.com/10.1002/lary.27807
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http://dx.doi.org/10.1002/lary.27807DOI Listing
January 2019
23 Reads

Genome-Wide Analysis of Head and Neck Squamous Cell Carcinomas Reveals HPV, TP53, Smoking and Alcohol-Related Allele-Based Acquired Uniparental Disomy Genomic Alterations.

Neoplasia 2019 02 4;21(2):197-205. Epub 2019 Jan 4.

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR; Precision Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.

Smoking and alcohol intake are major risk factors in head and neck squamous cell carcinomas (HNSCCs). Although the link between TP53 mutation and smoking has been well established, very little is known about the link between acquired uniparental disomy (aUPD) and smoking and/or alcohol consumption or other clinical characteristics. We used TCGA genomic data to investigate whether smoking, alcohol intake, clinical and demographic variables, HPV status and TP53 mutation are associated with aUPD at specific chromosomal regions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14765586183060
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http://dx.doi.org/10.1016/j.neo.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321975PMC
February 2019
2 Reads

A new approach to vocal cord leukoplakia and evaluation of proton pump ınhibitor treatment.

Eur Arch Otorhinolaryngol 2019 Feb 3;276(2):467-471. Epub 2019 Jan 3.

Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.

Purpose: Our aim is identify a new approach to vocal cord leukoplakia treatment and detect to efficiency of proton pump inhibitors.

Study Design: Prospective, nonrandomized experimental clinical trial.

Methods: A 'First Assessment Scale' was prepared. Read More

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http://dx.doi.org/10.1007/s00405-018-05273-9DOI Listing
February 2019
2 Reads

Impact of age at diagnosis of head and neck cancer on incidence of metachronous cancer.

BMC Cancer 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Head and Neck Surgery, Osaka International Cancer Institute, Osaka, Japan.

Background: Metachronous cancer in patients with head and neck cancer (HNC) is common and is associated with a poor prognosis. We aimed to evaluate the incidence of metachronous cancer at different sites according to age at diagnosis of index HNC.

Methods: We collected data on 2011 patients with oral cancer, oropharynx cancer, hypopharyngeal cancer, and laryngeal cancer as index cancers using the Osaka International Cancer Institute Cancer Registry database between 2005 and 2016. Read More

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http://dx.doi.org/10.1186/s12885-018-5231-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318848PMC
January 2019
2 Reads

Dual-energy computed tomography for prediction of loco-regional recurrence after radiotherapy in larynx and hypopharynx squamous cell carcinoma.

Eur J Radiol 2019 Jan 5;110:1-6. Epub 2018 Nov 5.

Radiation Oncology Department, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.

Purpose: To investigate the role of quantitative pre-treatment dual-energy computed tomography (DECT) for prediction of loco-regional recurrence (LRR) in patients with larynx/hypopharynx squamous cell cancer (L/H SCC).

Methods: Patients with L/H SCC treated with curative intent loco-regional radiotherapy and that underwent treatment planning with contrast-enhanced DECT of the neck were included. Primary and nodal gross tumor volumes (GTVp and GTVn) were contoured and transferred into a Matlab® workspace. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.11.005DOI Listing
January 2019
2 Reads

Mortality among workers exposed to asbestos at the shipyard of Genoa, Italy: a 55 years follow-up.

Environ Health 2018 12 29;17(1):94. Epub 2018 Dec 29.

Clinical Epidemiology, Ospedale Policlinico San Martino-IRCCS, Istituto di Ricovero e Cura a Carattere Scientifico per l'Oncologia, Genoa, Italy.

Background: Exposure to asbestos remains a global issue due to its massive use in the twentieth century and its long environmental persistence. Exposure to asbestos still occurs during dismantling of ships and vessels, buildings renovation, mining operations, and is reported in developing countries. Current estimate report exposure of hundreds of million people in occupational settings in countries where its use remains unregulated. Read More

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http://dx.doi.org/10.1186/s12940-018-0439-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310930PMC
December 2018
5 Reads

Salivary MicroRNAs for Early Detection of Head and Neck Squamous Cell Carcinoma: A Case-Control Study in the High Altitude Mestizo Ecuadorian Population.

Biomed Res Int 2018 21;2018:9792730. Epub 2018 Nov 21.

Centro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Avenue Mariscal Sucre, 170129 Quito, Ecuador.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with the highest incidence worldwide. HNSCC is often diagnosed at advanced stages, incurring significant high mortality and morbidity. The use of saliva, as a noninvasive tool for the diagnosis of cancer, has recently increased. Read More

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http://dx.doi.org/10.1155/2018/9792730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280231PMC
April 2019
2 Reads

Squamous cell carcinoma of the head and neck in children.

Int J Pediatr Otorhinolaryngol 2019 Feb 20;117:131-137. Epub 2018 Nov 20.

Department of Otolaryngology & Communication Enhancement, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, United States; Department of Otolaryngology, Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, United States. Electronic address:

Objective: To discuss the presentation, evaluation, and management of squamous cell carcinoma of the head and neck in the pediatric population.

Methods: Medical records of pediatric (≤20 years) patients treated for squamous cell carcinoma of the head and neck between 1996 and 2016 were reviewed. Data pertaining to clinical presentation, diagnostic methods, treatment plan, complications, recurrence, follow-up, or outcome were collected. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.11.019DOI Listing
February 2019
1 Read

Case of metastatic small cell carcinoma of the oropharynx successfully treated with image-guided volumetric modulated arc therapy (IG-VMAT): pushing the limits of technology to match treatment intent.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Department of Radiation Oncology, Batra Hospital & Medical Research Centre, New Delhi, Delhi, India.

Extrapulmonary small cell carcinomas (EPSCC) are a rare subtype of neuroendocrine tumours which have been documented to arise from a multitude of sites and treatment outcomes are disappointing. The most common site involved in the head and neck region is the larynx and the oropharynx as a primary site has been infrequently reported. The patient presented with bilateral neck swelling and an ulcerated lesion was noted in the base of tongue (BOT). Read More

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http://www.bmj.com/lookup/doi/10.1136/bcr-2018-226522
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http://dx.doi.org/10.1136/bcr-2018-226522DOI Listing
December 2018
9 Reads

Double pyramid technique of transoral laser partial laryngectomy for radiorecurrent laryngeal cancer.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Department of Otorhinolaryngology, Ninewells Hospital, NHS Tayside, Dundee, UK.

Management of recurrent head and neck cancer is challenging. Surgical treatments for residual or radiorecurrent laryngeal cancer include total laryngectomy, open partial laryngectomy and transoral laser microsurgery (TLM). TLM has been shown to achieve good oncological and functional outcomes in radiorecurrent laryngeal cancer. Read More

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http://dx.doi.org/10.1136/bcr-2018-224915DOI Listing
November 2018
2 Reads

Organ-preservation (chemo)radiotherapy for T4 laryngeal and hypopharyngeal cancer: is the effort worth?

Eur Arch Otorhinolaryngol 2019 Feb 18;276(2):575-583. Epub 2018 Dec 18.

Department of Head and Neck Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Purpose: We aimed to analyze the oncological and functional outcomes of chemoradiation for T4 laryngeal and hypopharyngeal cancer.

Methods: Patients treated between 2008 and 2015 with chemoradiation (n = 39) were retrospectively analyzed for oncological and functional (laryngo-esophageal dysfunction-free survival, LED-FS) outcomes and compared with 32 consecutive patients treated primarily with total laryngectomy (TL). LED was scored as event in case of local failure, TL for any reason, persistent tracheotomy and/or feeding tube dependency 2 years after chemoradiation. Read More

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http://dx.doi.org/10.1007/s00405-018-5241-8DOI Listing
February 2019
2 Reads

Variation in Nordic Work-Related Cancer Risks after Adjustment for Alcohol and Tobacco.

Int J Environ Res Public Health 2018 12 6;15(12). Epub 2018 Dec 6.

Department of Research, Cancer Registry of Norway, N-0304 Oslo, Norway.

: Alcohol and tobacco strongly increases the risk of cancers of the tongue, mouth, pharynx, larynx, and oesophagus, and are also established risk factors for cancer of the liver, colon, and rectum. It is well documented that these habits are unequally distributed among occupational groups. Most occupational cohort studies lack information on these potentially important confounders, and may therefore be prone to bias. Read More

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http://dx.doi.org/10.3390/ijerph15122760DOI Listing
December 2018
1 Read

Adenoid cystic carcinoma in ventricle of larynx: An interesting case.

Medicine (Baltimore) 2018 Dec;97(50):e13622

Department of Otolaryngology, First Affiliated Hospital, College of Medicine, Zhe Jiang University, Hangzhou.

Rationale: Adenoid cystic carcinomas (ACCs) are malignant tumors and occur in the major and the minor salivary glands. ACCs are rare in the larynx.

Patient Concerns: A 55-year-old female patient who presented with a 12 months history of paraesthesia pharynges and hoarseness for 4 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000013622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320204PMC
December 2018
3 Reads

The management of mid & proximal oesophageal squamous cell carcinoma.

Authors:
Ian Wong Simon Law

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:85-90. Epub 2018 Nov 30.

Division of Esophageal and Upper Gastrointestinal Surgery, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong. Electronic address:

Despite the rise in incidence of adenocarcinoma, squamous cell cancer of the oesophagus remains the commonest cell type worldwide and is predominant in the East. Except for very early tumours where endoscopic therapy can be performed with curative intent, in more advanced but potentially curative cancers, treatment for mid and upper third tumours is primarily surgery with extended lymphadenectomy, together with multimodal therapies such as preoperative chemotherapy or chemoradiotherapy. Definitive chemoradiotherapy is utilized in those who decline surgery or in those who are unfit for major procedures. Read More

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http://dx.doi.org/10.1016/j.bpg.2018.11.012DOI Listing
January 2019
3.478 Impact Factor

[Advances in prevention of pharyngocutaneous fistula after total laryngectomy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1917-1922

Total laryngectomy is a common method for the treatment of malignant tumors of the pharynx and larynx in China, but pharyngocutaneous fistula often happens after surgery, which burdens patients and affects postoperative recovery. At present, there are many measures to prevent pharyngocutaneous fistula, including strengthening nutrition pre-operative and post-operative, testing related indicators, controlling comorbidities, rational use of drugs, regular oral care, optimal selection of incision closure, and using of flaps and special materials during operation, etc. However, the choice of specific program needs to take care of the patient's condition, surgeon's skills and hospital conditions, and often requires multiple programs to be used together throughout the perioperative period. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.24.018DOI Listing
December 2018
10 Reads

Phonosurgical Resection Using Submucosal Infusion Technique for Early Glottic Lesions: Diagnostic and Therapeutic Procedure?

Ann Otol Rhinol Laryngol 2019 Apr 14;128(4):277-285. Epub 2018 Dec 14.

1 Clinic of Otolaryngology, Head and Neck Surgery, Department of Translational Surgery and Medicine, Careggi University Hospital, Florence, Italy.

Objectives:: The aim of this study was to assess the feasibility of the submucosal infusion combined with microflap dissection via laser CO2 as both a diagnostic and therapeutic procedure for superficial glottic lesions. To define a safe surgical procedure in terms of local control, a morphometric study of surgical margins was performed.

Methods:: From January 2011 to January 2016, we treated 122 patients with early glottic lesions with phonomicrosurgery. Read More

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http://dx.doi.org/10.1177/0003489418819544DOI Listing
April 2019
2 Reads

Symmetrical Apophyses on the Posterior Margins of the Thyroid Cartilage: A Previously Undescribed Anatomical Variation With Potential Forensic Implications.

Am J Forensic Med Pathol 2019 Mar;40(1):84-88

Departamento de Anatomía y Embriología Humana Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.

Differential diagnosis between normal/variant anatomy and pathological/traumatic findings represents one of the main matters of investigation of the so-called forensic clinical anatomy. In the literature, many anatomical variations of the laryngeal thyroid cartilage have been reported, with potential implications in forensic pathology. They include triticeal cartilages, foramen thyroideum, asymmetry, segmentation or agenesis of the superior thyroid horns, bone connections with the hyoid bone, absence of cricothyroid facets, hypertrophy of the inferior thyroid tubercle, and asymmetries in the thyroid notch, isthmus, or length of the inferior horn. Read More

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http://Insights.ovid.com/crossref?an=00000433-900000000-9917
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http://dx.doi.org/10.1097/PAF.0000000000000452DOI Listing
March 2019
4 Reads

Outcomes of Treating Early Glottic Neoplasms With a Potassium Titanyl Phosphate Laser.

Ann Otol Rhinol Laryngol 2019 Feb 11;128(2):85-95. Epub 2018 Dec 11.

2 Auckland City Hospital, Auckland, New Zealand.

Objectives:: The aim of this study was to assess the outcome of treating glottic dysplasia and early squamous cell carcinoma (SCC) with potassium titanyl phosphate (KTP) photoangiolytic laser ablation.

Methods:: Patient demographics, comorbidities, and tumor characteristics were recorded. Perceptual, patient-reported, and objective voice outcomes were assessed. Read More

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http://dx.doi.org/10.1177/0003489418806914DOI Listing
February 2019
10 Reads

Carbon Dioxide Laser Microsurgery versus Low-Temperature Plasma Radiofrequency Ablation for T1a Glottic Cancer: A Single-Blind Randomized Clinical Trial.

Biomed Res Int 2018 1;2018:4295960. Epub 2018 Nov 1.

Department of Otolaryngology, The Third Hospital of Wuhan City, Wuhan, Hubei Province, China.

Background: Very few studies have been conducted to compare carbon dioxide laser microsurgery (CO2-LS) with low-temperature plasma radiofrequency ablation (LTP-RFA) in treating T1a glottic cancer. Therefore, we conducted this study to compare the efficacy of CO2-LS and LTP-RFA to define a superior therapeutic modality for T1a glottic cancer.

Methods: Patients (n=131) with T1a glottic cancer were recruited between January 2010 and September 2014. Read More

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http://dx.doi.org/10.1155/2018/4295960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241367PMC
March 2019
3 Reads

Expression levels of miR-34-family microRNAs are associated with TP53 mutation status in head and neck squamous cell carcinoma.

Eur Arch Otorhinolaryngol 2019 Feb 4;276(2):521-533. Epub 2018 Dec 4.

Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Purpose: The majority of head and neck squamous cell carcinoma (HNSCC) cases in developing countries are associated with cigarette smoking and TP53 mutations. p53 is a transcription factor that activates downstream genes, including the hsa-miR-34a and hsa-miR-34b/c loci, to achieve cell-cycle arrest, senescence, and/or apoptosis. This study examined the differences in expression levels of miR-34 in HNSCC with or without TP53 mutations. Read More

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http://link.springer.com/10.1007/s00405-018-5223-x
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http://dx.doi.org/10.1007/s00405-018-5223-xDOI Listing
February 2019
9 Reads

Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study.

J Otolaryngol Head Neck Surg 2018 Dec 4;47(1):74. Epub 2018 Dec 4.

Department of Otolaryngology, Head and Neck Surgery, University of Ottawa, 501 Smyth Rd, Module S - Room M2566, Box 216, Ottawa, ON, K1H 8L6, Canada.

Background: We sought to expand upon preliminary data suggesting that metformin confers a survival benefit to patients with head and neck squamous cell carcinoma (HNSCC).

Methods: A large-scale retrospective cohort study of all patients in Ontario diagnosed with squamous cancer of the larynx, hypopharynx, and nasopharynx between Dec 1st 2007 to Dec 1st 2012 was undertaken. The Institute for Clinical and Evaluative Sciences was accessed to obtain patient demographic, treatment and outcome information. Read More

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http://dx.doi.org/10.1186/s40463-018-0322-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278022PMC
December 2018
2 Reads

Tuberculous neck lymphadenopathy: A diagnostic challenge.

J Stomatol Oral Maxillofac Surg 2018 Dec 1. Epub 2018 Dec 1.

Division of Maxillofacial Surgery, University of Eastern Piedmont, Novara, Italy.

Tuberculosis (TB) continues to be a major health problem for the developing world and a rise in the number of cases has been noted in the western hemisphere too. TB can affect most organs in the head and neck region, such as the lymph nodes, larynx, middle ear, oral cavity and pharynx. In particular, as for cervical tuberculosis lymphadenopathy, a predominant involvement of the posterior triangle, supraclavicular, and internal jugular group of nodes bilaterally can be observed. Read More

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http://dx.doi.org/10.1016/j.jormas.2018.11.012DOI Listing
December 2018
6 Reads

Prophylaxis with oral zinc sulfate against radiation-induced oropharyngeal mucositis in patients with head and neck cancer: Protocol for a meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2018 Nov;97(48):e13310

Department of Nursing, Peking University of Stomatology Hospital, Beijing.

Background: Oropharyngeal mucositis is considered to be an inevitable and the most troubling side effect of head and neck irradiation, which is caused by the direct toxic action of radiation on oral mucosa. Several randomized controlled trials (RCTs) have investigated the efficacy of zinc sulfate in prevention of radiation-induced oropharyngeal mucositis in patients with head and neck cancer. However, the definite conclusions have not been confirmed. Read More

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http://dx.doi.org/10.1097/MD.0000000000013310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283232PMC
November 2018
16 Reads

Expression of Genes Encoding Cell Motility Proteins during Progression of Head and Neck Squamous Cell Carcinoma.

Bull Exp Biol Med 2018 Dec 28;166(2):250-252. Epub 2018 Nov 28.

Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences, Moscow, Russia.

The model of head and neck squamous cell carcinoma (HNSCC) was used to study the expression of genes encoding actin-binding proteins depending on the type of cell motility. The expression of SNAIL1 and CAPN2 mRNA in HNSCC tissue was higher than in specimens of dysplastic epithelium of the larynx and hypopharynx, which can be explained by activation of mesenchymal and amoeboid types of cell motility. In biopsy material of HNSCC patients with T1-2N0M0, expression of genes responsible for actin-binding proteins differed from that of patients with pretumor pathology of the larynx and hypopharynx: expression of FSCN was lower, while expressions of EZR and CAP1 were higher. Read More

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http://dx.doi.org/10.1007/s10517-018-4325-1DOI Listing
December 2018

A Comparative Study of Two Chemo-Radiation Regimens for the Cancer of Larynx

Asian Pac J Cancer Prev 2018 Nov 29;19(11):3265-3270. Epub 2018 Nov 29.

Department of Radiation Oncology, Super speciality Cancer Institute, Lucknow, India. Email:

The region of head and neck is critical for respiration, nutrition, and speech. The management of laryngeal tumours can stimulate mutilations and cosmetic deformities and worsen the life. A “non-operative approach” is preferred for patients to whom radiation following surgery, possibly, will direct severe functional destruction predominantly in advanced stage patients having a bulk of carcinoma larynx. Read More

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http://dx.doi.org/10.31557/APJCP.2018.19.11.3265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318399PMC
November 2018
9 Reads
1.500 Impact Factor

Laryngeal synovial sarcoma: Report of 2 cases.

J Egypt Natl Canc Inst 2018 Dec 24;30(4):173-176. Epub 2018 Nov 24.

ENT Department, Farhat Hached University Hospital, Sousse, Tunisia.

Synovial sarcoma is a malignant mesenchymal tumor. It most commonly occurs in the lower extremities of young adults. The head and neck are rare sites, accounting for less than 10%. Read More

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http://dx.doi.org/10.1016/j.jnci.2018.10.002DOI Listing
December 2018
20 Reads

Dosimetric impact of Acuros XB dose-to-water and dose-to-medium reporting modes on VMAT planning for head and neck cancer.

Phys Med 2018 Nov 15;55:107-115. Epub 2018 Nov 15.

Department of Medical Sciences, University of Girona, C/Emili Grahit 77, 17003 Girona, Spain; Department of Radiology, Clínica Girona, Institut de Diagnòstic per la Imatge, C/Lorenzana 36, 17002 Girona, Spain. Electronic address:

Purpose: To assess the dosimetric impact of switching from the Analytical Anisotropic Algorithm (AAA) to Acuros XB (AXB) for both dose-to-medium (Dm) and dose-to-water (Dw) in VMAT for H&N patients. To study whether it should be linked to a change in the dose prescriptions to the PTVs and in the constraints to the OARs.

Methods: 110H&N patients treated with VMAT were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11201797183131
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http://dx.doi.org/10.1016/j.ejmp.2018.10.024DOI Listing
November 2018
14 Reads

Long-Term Exposure to Air Pollutants and Cancer Mortality: A Meta-Analysis of Cohort Studies.

Int J Environ Res Public Health 2018 11 21;15(11). Epub 2018 Nov 21.

Department of Medicine, Graduate School of Yonsei University, 50-1 Yonsei-ro, Seodaemoon-gu, Seoul 03722, Korea.

The aim of this study was to examine the relationship between main air pollutants and all cancer mortality by performing a meta-analysis. We searched PubMed, EMBASE (a biomedical and pharmacological bibliographic database of published literature produced by Elsevier), and the reference lists of other reviews until April 2018. A random-effects model was employed to analyze the meta-estimates of each pollutant. Read More

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http://dx.doi.org/10.3390/ijerph15112608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266691PMC
November 2018