22,457 results match your criteria Malignant Tumors of the Larynx


The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database.

Clin Transl Oncol 2020 May 21. Epub 2020 May 21.

Division of Hematology/Oncology, Department of Internal Medicine, Creighton University Medical Center, Omaha, NE, USA.

Purpose: Basaloid squamous cell carcinoma (BSCC) of the head and neck is an aggressive and highly malignant variant of squamous cell carcinoma that accounts for 2% of head and neck cancers. Previous studies have not analyzed the significance of adjuvant chemoradiation and anatomical site within BSCC subtype and its impact on survival.

Methods: A cohort of 1999 patients with BSCC of the head and neck was formed from the National Cancer Database and analyzed with descriptive studies, median survival and 5- and 10-year survival. Read More

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http://dx.doi.org/10.1007/s12094-020-02370-2DOI Listing

Well-Differentiated/Dedifferentiated Liposarcoma Arising in the Upper Aerodigestive Tract: 8 Cases Mimicking Non-adipocytic Lesions.

Head Neck Pathol 2020 May 14. Epub 2020 May 14.

Anatomic Pathology - Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA.

Well-differentiated (WDL) and dedifferentiated liposarcomas (DL) of the pharynx, larynx and oral cavity are rare, often mimicking benign lipomatous neoplasms or non-lipogenic mesenchymal tumors. Cases of WDL/DL arising in the upper aerodigestive tract, exclusive of the cervical esophagus, were reviewed. Morphologic features, ancillary studies, including fluorescence in situ hybridization (FISH) studies for CPM/MDM2, and clinical data was catalogued. Read More

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http://dx.doi.org/10.1007/s12105-020-01171-xDOI Listing

Simultaneous Malignant and Benign Nonepithelial Neoplasms of the Larynx-A Case Report and Literature Review.

Ear Nose Throat J 2020 May 8:145561320925567. Epub 2020 May 8.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Warsaw, Poland.

Nonepithelial tumors of the larynx are relatively rare neoplasms of the head and neck. The chondrosarcoma, which develops commonly from cricoid and thyroid cartilage, stands for 0.2% of the laryngeal malignant neoplasms. Read More

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http://dx.doi.org/10.1177/0145561320925567DOI Listing

Surgical Considerations for an Awake Tracheotomy During the COVID-19 Pandemic.

J Laparoendosc Adv Surg Tech A 2020 May 20;30(5):477-480. Epub 2020 Apr 20.

Department of Otolaryngology-Head and Neck Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.

The current global COVID-19 pandemic is caused by the novel coronavirus Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). Given that SARS-CoV-2 is highly transmissible, surgical societies have recommended that procedures with a high risk of aerosolization be avoided or delayed. However, some high-risk procedures, such as those related to head and neck malignancies, cannot always be delayed. Read More

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http://dx.doi.org/10.1089/lap.2020.0239DOI Listing

Prognostic Potential of the Expression of Podoplanin (D2-40) Within Cells of Squamous Cell Carcinoma of the Larynx and Hypopharynx.

World J Oncol 2020 Apr 29;11(2):65-71. Epub 2020 Mar 29.

Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital of Wuerzburg, Josef-Schneider-Str. 2, D-97080 Wuerzburg, Germany.

Background: Podoplanin (D2-20) stains immunohistochemically lymphatic vessels, regular mesothelium and tumor cells of different tumors, e.g. malignant mesothelioma or seminoma. Read More

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http://dx.doi.org/10.14740/wjon1259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141162PMC

Research Progress Regarding Surgical Margins, Molecular Margins, and Prognosis of Laryngeal Carcinoma.

Ear Nose Throat J 2020 Apr 3:145561320903146. Epub 2020 Apr 3.

Department of Otorhinolaryngology and Maxillofacial Oncology, Laboratory of Cancer Cell Biology, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.

Background: Laryngeal carcinoma is one of the most common malignant tumors of the head and neck. Researchers have refined the study of surgical margin in the anatomical subarea of the larynx to determine the most appropriate distance of the surgical margin for laryngeal carcinoma, to achieve accurate resection of laryngeal carcinoma and to improve the possibility of retention of laryngeal function.

Methods: A comprehensive review of the primary literature was performed from 2009 to 2019 utilizing keywords laryngeal carcinoma, surgical margin, molecular margin, and prognostic factor. Read More

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http://dx.doi.org/10.1177/0145561320903146DOI Listing
April 2020
0.881 Impact Factor

Benign and Malignant Granular Cell Tumor of the Hypopharynx: Two Faces of a Rare Entity.

Head Neck Pathol 2020 Apr 2. Epub 2020 Apr 2.

University of Miami Hospital, Miller School of Medicine, 1400 NW 12th Avenue, Room 4078, Miami, FL, 33136, USA.

Granular cell tumors (GCT) are rare soft tissue tumors that involve the head and neck in 50% of patients. Two distinct variants of GCT, one benign (bGCT) and the other malignant (mGCT), involving the hypopharynx, a subsite of the larynx, are presented here. The clinical presentations, radiographic features, pathologic diagnosis in these two variants of GCT are discussed. Read More

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http://dx.doi.org/10.1007/s12105-020-01157-9DOI Listing

[Analysis of Collision Carcinoma of Larynx Between Moderately Differentiated Squamous Cell Carcinoma and Poorly Differentiated Neuroendocrine Carcinoma from One Case].

Sichuan Da Xue Xue Bao Yi Xue Ban 2020 Mar;51(2):261-263

Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.

A 75-year-old male patient was hospitalized in hoarseness for 2 months. Laryngoscopy showed a mass protruding in right laryngeal chamber and covering the middle part of right vocal cord. Since tumor biopsy showed low differentiation cancer, he received total laryngectomy, and post-operative pathological result found composite carcinoma, which containing medium differentiated squamous cell carcinoma (about 5%) and low differentiated neuroendocrine carcinoma (about 95%). Read More

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http://dx.doi.org/10.12182/20200360202DOI Listing

Opium Use and Head and Neck Cancers: A Matched Case-Control Study in Iran.

Asian Pac J Cancer Prev 2020 03 1;21(3):783-790. Epub 2020 Mar 1.

Department of Otorhinolaryngology Head and Neck Surgery, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.

Background: Head and Neck (H and N) cancers include malignant tumors of the nasal cavity, pharynx, paranasal sinuses, oral cavity, larynx and salivary glands. Opium use might be related to these cancers. The aim of this study was to investigate the relation between Opium and its Derivatives (O and D) use and the incidence of H and N cancers. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.3.783DOI Listing
March 2020
1.500 Impact Factor

[A Case Report on Larynx-Preserving Surgery with Tracheal Resection of an Advanced Esophageal Cancer with Tracheal Invasion].

Gan To Kagaku Ryoho 2019 Dec;46(13):2530-2532

Dept. of Gastroenterological Surgery, Graduate School of Medicine, Osaka University.

We present the case of a 69-year-old man who was diagnosed with ascending colon cancer. Preoperative CT revealed 2 advanced esophageal cancers, both at T4; thus, a diagnosis of esophageal cancer(Ut-Ce, cT4b[Tr]N2M0, Stage ⅣA/Mt, cT4b[Lt-Br]N2M0, Stage ⅣA)was made. The patient received chemotherapy(DTX/CDDP/5-FU), and as the second-line treatment, he received chemoradiotherapy(40 Gy with DTX/CDDP/5-FU). Read More

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December 2019

Imaging features of non-epithelial tumours of the larynx.

Clin Radiol 2020 Feb 21. Epub 2020 Feb 21.

Department of Radiology, Cumberland Infirmary, Carlisle, CA2 7HY, UK.

Neoplasms of the head and neck most commonly seen within the larynx are likely malignant and epithelial in origin. Although uncommon, non-epithelial types are occasionally encountered in clinical practice. Owing to the rare nature of these entities, they can lead to diagnostic and treatment uncertainty. Read More

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http://dx.doi.org/10.1016/j.crad.2020.01.013DOI Listing
February 2020

Granular cell tumor a study of 42 cases and systemic review of the literature.

Pathol Res Pract 2020 Apr 12;216(4):152865. Epub 2020 Feb 12.

Department of Pathology, North Hospital, University Hospital of St-Etienne, France.

Background: Granular cell tumor (GCT) remains a diagnostic clinicopathologic problem because the exact frequency of its detailed morphological and clinical characteristics is unknown as most observations are collected from small series or isolated cases. Herein, our aim is to highlight the frequency of all clinicopathological characteristics of this rare tumor based in our series and the available medical (PubMed) literature.

Material And Methods: 42 cases were evaluated for: tissue layers involved by the tumor (in skin and mucosae), growth pattern, nuclear pleomorphism, mitotic index, necrosis, spindling, calcification, hyalinization, and pustule-ovoid bodies of Milian, as well as perineural and vascular invasion, and the presence of adjacent epithelium changes, and lymphocytes and eosinophils infiltration. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152865DOI Listing

[Voice analysis of early glottic carcinoma treated by carbon dioxide laser].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;34(2):162-165

Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery(Capital Medical University),Ministry of Education,Beijing,100730,China.

The aim of this study is to investigate the effect of CO2 laser cordectomy on the voice of early glottic carcinoma. A retrospective analysis of 40 patients who underwent CO2 laser treatment early glottis preoperative clinical data of postoperative laryngeal cancer patients, patients with postoperative recurrence rate, survival rate, and the postoperative complications of patients with preoperative and postoperative laryngoscopy, voice disorders index(voice handicap index, VHI) simplified Chinese version(VHI 13) rating scale, affecting the stability sound quality postoperatively in patients with laryngeal cancer were discussed. All patients underwent voice reexamination 8-97 months after surgery, and the survival rate was 100%, no local recurrence and no obvious postoperative complications. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2020.02.015DOI Listing
February 2020

Complications and predisposing factors from a decade of total laryngectomy.

J Laryngol Otol 2020 Mar 21;134(3):256-262. Epub 2020 Feb 21.

Department of Otolaryngology, Head and Neck Surgery, Edinburgh Cancer Centre, Western General Hospital, Scotland, UK.

Background: Total laryngectomy is often utilised to manage squamous cell carcinoma of the larynx or hypopharynx. This study reports on surgical trends and outcomes over a 10-year period.

Method: A retrospective review of patients undergoing total laryngectomy for squamous cell carcinoma was performed (n = 173), dividing patients into primary and salvage total laryngectomy cohorts. Read More

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http://dx.doi.org/10.1017/S0022215120000341DOI Listing

[Meta-analysis of comparison for efficacies between surgical plus radio(chemo)therapy and non-surgery chemoradiotherapy treatment strategies for advanced hypopharyngeal cancer].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;55(2):144-149

the First Clinical College of Shanxi Medical University, Taiyuan 030001, China.

Meta-analysis was used to compare the long-term efficacy and laryngeal function preservation rate of patients with advanced hypopharyngeal cancer treated with surgery plus radio(chemo)therapy (SRT) or non-surgery chemoradiotherapy (CRT). We searched publicly published articles on case-control studies of surgical and non-surgical comprehensive treatment of advanced hypopharyngeal cancer in PubMed, the Cochrane Library, Wanfang Database, Chinese Journal Full-text Database, and Chinese Science and Technology Periodical Database. The search language was limited to Chinese and English, and the period was from 1990 to 2018. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2020.02.011DOI Listing
February 2020

Cell-type-specific signaling networks in heterocellular organoids.

Nat Methods 2020 03 17;17(3):335-342. Epub 2020 Feb 17.

Cell Communication Lab, Department of Oncology, University College London Cancer Institute, London, UK.

Despite the widespread adoption of organoids as biomimetic tissue models, methods to comprehensively analyze cell-type-specific post-translational modification (PTM) signaling networks in organoids are absent. Here, we report multivariate single-cell analysis of such networks in organoids and organoid cocultures. Simultaneous analysis by mass cytometry of 28 PTMs in >1 million single cells derived from small intestinal organoids reveals cell-type- and cell-state-specific signaling networks in stem, Paneth, enteroendocrine, tuft and goblet cells, as well as enterocytes. Read More

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http://dx.doi.org/10.1038/s41592-020-0737-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060080PMC
March 2020
32.072 Impact Factor

Effect of the sense of coherence and associated factors in the quality of life of head and neck cancer patients.

Braz Oral Res 2020 7;34:e009. Epub 2020 Feb 7.

Universidade Federal de Santa Maria (UFSM), School of Dentistry, Department of Pathology, Santa Maria, RS, Brazil.

The sense of coherence (SOC) is a measure of global orientation regarding the ability of individuals to cope with stressful situations. The aim of the present study was to evaluate the association between SOC and quality of life (QoL) and clinical and sociodemographic characteristics among survivors of oral, oropharynx, hypopharynx, or larynx cancer. A cross-sectional study was conducted with 90 cancer patients in follow up at the Santa Maria University Hospital in southern Brazil who had completed conformal 3D radiotherapy at least three months earlier. Read More

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http://dx.doi.org/10.1590/1807-3107bor-2020.vol34.0009DOI Listing
February 2020

[LARYNGEAL MALIGNANCIES IN ISRAEL - THE DIAGNOSIS, CLASSIFICATION AND TREATMENT OF NEUROENDOCRINE TUMORS].

Harefuah 2020 Feb;159(1):83-87

Department of Otolaryngology / Head and Neck Surgery, Hadassah University Hospital, Jerusalem, Israel.

Introduction: The larynx is the most common site of neuroendocrine tumors in the head and neck region. Tumors are divided morphologically into epithelial-derived tumors (carcinomas) and neural-derived tumors (paragangliomas). The classification of neuroendocrine tumors has evolved over the past two decades. Read More

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February 2020

[EARLY LARYNGEAL CANCER - TREATMENT OUTCOMES OF TRANSORAL LASER MICROSURGERY].

Harefuah 2020 Feb;159(1):77-82

Department of Otolaryngology Head and Neck Surgery, Carmel Medical Center, Haifa, Israel.

Aims: To evaluate predictive factors for local control, larynx preservation and overall survival in patients with early laryngeal cancer, who were treated with endoscopic transoral CO2 laser microsurgery.

Background: Transoral laser microsurgery (TLM) is the treatment of choice for early laryngeal cancer. The current study aimed to assess the outcomes and validity of carbon dioxide (CO2) laser microsurgery in patients with early larynx cancer and to determine predictors for outcomes. Read More

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February 2020

Prognostic implications of human papillomavirus type 16 status in non-oropharyngeal head and neck cancer: a propensity score matching analysis.

Ann Transl Med 2019 Dec;7(23):759

Department of Otolaryngology-Head and Neck Surgery, China.

Background: The purpose of this study was to investigate the association between HPV 16 status and survival outcomes in patients with non-oropharyngeal squamous carcinoma (non-OPSCC).

Methods: Patients with non-OPSCC diagnosed between 2006 and 2016 were included in this study. The presence of HPV 16 DNA was confirmed by quantitative real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.21037/atm.2019.11.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989993PMC
December 2019

Estimation of Occupational Exposure to Asbestos in Italy by the Linkage of Mesothelioma Registry (ReNaM) and National Insurance Archives. Methodology and Results.

Int J Environ Res Public Health 2020 02 6;17(3). Epub 2020 Feb 6.

Unit of Medical Statistics and Cancer Epidemiology, Department of Translational Medicine, University of Eastern Piedmont, Novara, CPO-Piedmont, 28100 Novara, Italy.

The identification and monitoring of occupational cancer is an important aspect of occupational health protection. The Italian law on the protection of workers (D. Leg. Read More

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http://dx.doi.org/10.3390/ijerph17031020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037801PMC
February 2020

Long-term outcomes of living donor liver transplantation in patients with a prior history of nonhepatic malignancy.

Biosci Trends 2020 Mar 5;14(1):42-47. Epub 2020 Feb 5.

Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

Posttransplant malignancy has become a significant cause of mortality. Data on the long-term outcomes of patients with pretransplant nonhepatic malignancy (PTM) after living donor liver transplantation (LDLT) are scarce, although the recipients of other organs with PTM have been reported to have a poor survival. Fifteen patients with PTM (4. Read More

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http://dx.doi.org/10.5582/bst.2019.01313DOI Listing

Topoisomerase IIa Protein Expression Patterns in Laryngeal Squamous Cell Carcinoma.

Anticancer Res 2020 Feb;40(2):807-811

First Department of Otorhinolaryngology, Head and Neck Surgery, Hippocration Hospital, University of Athens, Athens, Greece.

Background/aim: Topoisomerase II alpha (TopoIIa) is a critical gene associated with response to chemo-therapeutic agents, such as anthracyclines, especially in breast adenocarcinoma. The aim of this study was to investigate the role of aberrant TopoIIa protein expression in laryngeal squamous cell carcinoma (LSCC).

Materials And Methods: Fifty (n=50) LSCC cases were enrolled in the study. Read More

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http://dx.doi.org/10.21873/anticanres.14012DOI Listing
February 2020

Evaluating for disparities in place of death for head and neck cancer patients in the United States utilizing the CDC WONDER database.

Oral Oncol 2020 Jan 29;102:104555. Epub 2020 Jan 29.

Department of Radiation Oncology, Duke University Medical Center, DUMC Box 3085, Durham, NC 27710, USA. Electronic address:

Objective: Evaluate trends in place of death for patients with head and neck cancers (HNC) in the U.S. from 1999 to 2017 based on the CDC WONDER (Wide-ranging Online Data for Epidemiologic Research) database. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.104555DOI Listing
January 2020

[Angiolytic laser applications for the larynx : Phonosurgical concepts for transoral laser microsurgery].

HNO 2020 Jan;68(1):59-68

Deutsche Stimmklinik, Martinistr. 64, 20251, Hamburg, Deutschland.

Transoral laser microsurgery (TLM) for treatment of laryngeal cancer has reduced temporary tracheotomies, increased organ preservation rates, and improved functional results. Gold standard for laser-based transoral resection of laryngeal cancer is the application of CO lasers. Oncologically safe radical resection and postoperative voice outcome must be weighed up individually. Read More

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http://dx.doi.org/10.1007/s00106-019-00801-3DOI Listing
January 2020

Head and neck cancer in Styria : An epidemiologic and clinical audit.

Wien Klin Wochenschr 2020 Jan 15. Epub 2020 Jan 15.

Department of Otorhinolaryngology, Head and Neck surgery, Medical University of Graz, Auenbruggerplatz 26, 8036, Graz, Austria.

Background: The outcome of patients with cancer of the head and neck is significantly improved by increased interdisciplinary cooperation. The main focus of this study was a comparison of epidemiologic factors (age, sex, origin, staging) of patients with head and neck cancer in Styria, with those for patients throughout Austria.

Methods: A retrospective data analysis of collected archived tumor board protocols of the Comprehensive Cancer Center (CCC) Graz included the patient's age, sex, area of residence, TNM stage, reasons for inoperability, comorbidities and performance status by ECOG (Eastern Cooperative Oncology Group), was performed. Read More

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http://dx.doi.org/10.1007/s00508-019-01591-yDOI Listing
January 2020

[The progress of narrow band imaging endoscopy in diagnosis of vocal cord leukoplakia].

Authors:
B G Zhang X G Ni

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Nov;33(11):1113-1116

The appearances of vocal cord leukoplakia are largely identical in the macroscopic examination even though the pathological character may differ. This makes it difficult for physicians to evaluate the extent of dysplasia of vocal cord leukoplakia and detect the occurrence of canceration using the conventional laryngoscopy, which might result in overtreatment or undertreatment of vocal cord leukoplakia in different patients. Therefore, an accurate preoperative assessment of the pathological character of vocal cord leukoplakia shows clinical significance in the selection of an appropriate treatment plan and predicting the prognosis of a patient. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.11.027DOI Listing
November 2019

[The progress on diagnosis and treatment of larynx cancer].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Nov;33(11):1017-1021

Laryngeal cancer remains one of the most common tumors of head and neck. While significant advancements have been made over the last several decades, diagnosis and treatment of laryngeal cancer presents an unique challenge given its complexity. It is essential to perform a thorough preoperative assessment by the dedicated multidisciplinary team(MDT), including confirmed diagnosis, accurate staging, surgical selection, rehabilitation and reconstruction, supportive care and postoperative follow-up. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.11.003DOI Listing
November 2019

[Canceration of inflammatory myofibroblastic tumor of the larynx:a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Dec;33(12):1211-1213

Inflammatory myofibroblastic tumor(IMT) is a rare spindle neoplasm with malignant potentials of local invasion, recurrence and metastasis. Here, we present an extremely unusual case of the larynx IMT that was recurred three times and transformed into laryngeal squamous cell carcinoma. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.12.025DOI Listing
December 2019

[Three cases of head and neck carcinosarcoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Dec;33(12):1209-1211

Head and neck carcinosarcoma leads to kinds of manifestations because of different original tumor sites, such as hoarseness and dyspnea in larynx, pharyngalgia and dysphagia in pharynx and compression in neck. Imaging examinations show specific occupying tumor sites and sometimes discover peripheral invasion. Pathological examination reveals both malignant squamous epithelium and interstitial tissue in these tumors,and therefore we diagnose these tumors as carcinosarcoma. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.12.024DOI Listing
December 2019

[Vocal cords myxoma misdiagnosed as vocal cord polyp:a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Dec;33(12):1206-1206;1208

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.12.022DOI Listing
December 2019

[Curative effect observation of application of the snare in epiglottic cystectomy by arc-shaped laryngoscopy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Dec;33(12):1162-1164

Department of Otolaryngology Head and Neck Surgery,Peking University Third Hospital,Beijing,100191,China.

To evaluate the effect of the epiglottic cystectomy by arc-shaped video laryngoscopy combined with snare. The clinical data of 42 patients with epiglottic cysts were retrospectively analyzed. Forty-two patients with epiglottis cyst were treated by arc-shaped video laryngoscopy combined with snare. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.12.011DOI Listing
December 2019

Head and neck verrucous carcinoma: A population-based analysis of incidence, treatment, and prognosis.

Medicine (Baltimore) 2020 Jan;99(2):e18660

School of Nursing, Hubei University of Science and Technology, Xianning, China.

Verrucous carcinoma is a rare variant of squamous cell carcinoma. The oral cavity, genitals, larynx, esophagus, and skin are usually affected, and the head and neck regions are the most affected areas. Few studies reported about head and neck verrucous carcinoma (VC) in the literature. Read More

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http://dx.doi.org/10.1097/MD.0000000000018660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959962PMC
January 2020

Rehabilitation of a Head and Neck Cancer Survivor With a Functionally and Biomechanically Challenged Dentition.

Compend Contin Educ Dent 2020 01;41(1):42-49

Private Practice, Mason, Ohio.

Radiation therapy for patients with head and neck cancer can have damaging effects on oral health, including reduced salivary flow. In this case report, a 58-year-old patient had previously undergone radiation therapy for stage II squamous cell carcinoma of the larynx. Symptoms of xerostomia persisted, and her dentition suffered as a result. Read More

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January 2020

[TREATMENT AND PREVENTION OF METASTASIS TO THE PRE- AND PARATRACHEAL LYMPH NODES IN CANCER OF THE LARYNX WITH SPREAD TO THE SUBGLOTTIC SECTION].

Georgian Med News 2019 Nov(296):12-15

Oncological Research Center of Georgia; Tbilisi Satate Medical Universtity, Institute of Medical Biotechnology, Georgia.

Based on the specificity of the subglottic cancer, the basic method of treatment is surgical, because many years of experience have shown the ineffectiveness of chemotherapy and the low effectiveness of radiation therapy. We have developed and introduced in practice the method of extended-combined laryngectomy is effective not only in terms of treating the underlying disease, but also for preventive purposes, reducing the risk of metastases in pre- and paratracheal lymphatic zones. The method of extended-combined laryngectomy includes mobilization of the larynx and its removal at level V or VI of the tracheal rings, lymph node dissection at level VI, both on the affected side and prophylactically from the opposite side, as well as removal of either the thyroid gland on the side of the lesion subglottic cancer, or at its circulatory location total removal of the gland. Read More

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November 2019

Prospective assessment of the clinical benefit of a tailored cancer gene set built on a next-generation sequencing platform in patients with recurrent or metastatic head and neck cancer.

Med Oncol 2019 Dec 21;37(2):12. Epub 2019 Dec 21.

Division of Medical Oncology, Washington University School of Medicine, 660 South Euclid, Campus Box 8056, St. Louis, MO, 63110, USA.

We performed a prospective trial to assess the clinical benefit of a tailored gene set built on a next-generation sequencing (NGS) platform in patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Archived tumor tissue obtained from patients with recurrent or metastatic HNSCC was analyzed for variants by a tailored Comprehensive Cancer Gene set of 40 genes (CCG-40) performed on a NGS platform. These data were provided to clinicians to inform treatment decisions. Read More

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http://dx.doi.org/10.1007/s12032-019-1336-3DOI Listing
December 2019

Metastatic retroperitoneal tumor from a non-functional neuroendocrine neoplasia of the left ethmoid-nose-orbitary region: Case report and short review of literature.

Int J Surg Case Rep 2020 14;66:169-173. Epub 2019 Dec 14.

General and Emergency Surgery, St. Camillo-Forlanini Hospital, Rome, Italy.

Introduction: NeuroEndocrine Neoplasms (NENs) are rare and can originate from any epithelial organ. We describe a very rare case of retroperitoneal metastasis from a non-functioning neuroendocrine tumor of the ethmoid region and focus on the various issues related to NENs, from their nosological classification up to the most recent acquisitions in the diagnostic and therapeutic field.

Presentation Of Case: A woman presented with a mass in the right retroperitoneal area that infiltrated liver and kidney. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928331PMC
December 2019

Laryngeal adenoid cystic carcinoma: Three cases reports.

Medicine (Baltimore) 2019 Dec;98(51):e18177

Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin, P.R. China.

Introduction: Laryngeal adenoid cystic carcinoma (LACC) is an extremely rare malignant neoplasm. The etiology of LACC remains unknown, and it is characterized by multiple recurrences, slow progression, and late distant metastasis. This study aimed to provide more information regarding the characteristics, diagnosis, and treatment of LACC by analyzing 3 clinical cases and reviewing the literature on this topic. Read More

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http://dx.doi.org/10.1097/MD.0000000000018177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940171PMC
December 2019

Feasibility of single vocal cord irradiation as a treatment strategy for T1a glottic cancer.

Head Neck 2020 May 19;42(5):854-859. Epub 2019 Dec 19.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.

Background: Generally, radiotherapy for patients with early glottic cancer includes treatment of the whole larynx. This study was conducted to evaluate the treatment outcomes and toxicity in patients who received single vocal cord irradiation (SVCI) for T1a classification glottic cancer.

Methods: A total of 34 patients diagnosed with clinical T1aN0M0 classification squamous cell carcinoma of the glottis who received radiotherapy to the single vocal cord were included for analysis. Read More

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http://dx.doi.org/10.1002/hed.26052DOI Listing

Unique Patterns of Distant Metastases in HPV-Positive Head and Neck Cancer.

Oncology 2020 17;98(3):179-185. Epub 2019 Dec 17.

Division of Hematology and Oncology, UT Southwestern Medical Center, Dallas and Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas, USA,

Background: HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC) demonstrates favorable outcomes compared to HPV-negative SCC, but distant metastases (DM) still occur. The pattern of DM in HPV+ HNSCC is unclear.

Methods: 1,494 HNSCC patients were treated from 2006 to 2012. Read More

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http://dx.doi.org/10.1159/000504651DOI Listing

Patterns of Care and Outcomes of Intensity-Modulated Radiotherapy and 3D Conformal Radiotherapy for Early Stage Glottic Cancer: A National Cancer Database Analysis.

Cancers (Basel) 2019 Dec 12;11(12). Epub 2019 Dec 12.

Department of Radiation and Cellular Oncology, University of Chicago Medical Center, Chicago, IL 60637, USA.

Early stage glottic cancer has traditionally been treated with 3D conformal radiotherapy (3DCRT). However, intensity-modulated radiotherapy (IMRT) has been recently adopted as an alternative to decrease toxicity. Here, we compared the usage and outcomes of IMRT and 3DCRT for patients with early stage squamous cell carcinoma (SCC) of the glottic larynx. Read More

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http://dx.doi.org/10.3390/cancers11121996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966448PMC
December 2019

Prognostic significance of surgical margins after transoral laser microsurgery for early-stage glottic cancer.

Oral Oncol 2020 01 10;100:104511. Epub 2019 Dec 10.

Head and Neck Services, Tata Memorial Hospital, Dr E Borges Road, Parel, Mumbai 400012, India; Homi Bhabha National Institute, Mumbai, India.

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http://dx.doi.org/10.1016/j.oraloncology.2019.104511DOI Listing
January 2020

HPV infection and clinical profiles in laryngeal diseases. A preliminary study.

Ann Ital Chir 2019 ;90:398-403

Purpose: The study analysed the presence of HPV in samples tissue from laryngeal chronic hyperplastic inflammation, with and without pre-neoplastic potential, and from squamous cell carcinoma of the larynx. The aim of this analysis was to evaluate the presence/absence of different types of HPV and their relationship to the clinical profile of the patients studied (habit of smoking and drinking).

Methods: Sixty cases were randomly selected from patients undergoing surgical treatment of the larynx for inflammatory/ neoplastic lesions and of neck nodes. Read More

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Primary Sarcomas of the Larynx: A Single Institutional Experience with Ten Cases.

Head Neck Pathol 2019 Dec 7. Epub 2019 Dec 7.

Department of Pathology, University of Washington, 1959 NE Pacific Street, Box 356100, Seattle, WA, 98195, USA.

Sarcomas infrequently arise in the larynx where the vast majority of tumors are of epithelial origin. Given their rarity, studies of these lesions are limited in number. In this series, we describe our institutional experience with ten primary sarcomas of the larynx encountered over an 18 year period, comprising 1. Read More

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http://dx.doi.org/10.1007/s12105-019-01106-1DOI Listing
December 2019

Chondrom des Schildknorpels.

Authors:

Laryngorhinootologie 2019 Dec 6;98(12):844. Epub 2019 Dec 6.

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http://dx.doi.org/10.1055/a-0954-8067DOI Listing
December 2019

Concordance between sites of tumor development in humans and in experimental animals for 111 agents that are carcinogenic to humans.

J Toxicol Environ Health B Crit Rev 2019 ;22(7-8):203-236

McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Ottawa, Canada.

Since the inception of the in the early 1970s, this has developed 119 Volumes on more than 1000 agents for which there exists some evidence of cancer risk to humans. Of these, 120 agents were found to meet the criteria for classification as (Group 1). Volume 100 of the , compiled in 2008-2009 and published in 2012, provided a review and update of the 107 Group 1 agents identified as of 2009. Read More

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http://dx.doi.org/10.1080/10937404.2019.1642586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139235PMC

[Surgical interventions on the pharynx in the structure of otorhinolaryngological care to the population of the city of Moscow].

Vestn Otorinolaringol 2019 ;84(5):32-37

The Sverzhevskiy's Otorhinolaryngology Healthcare Research Institute, Moscow, Russia, 117152.

The authors studied the reporting documentation of otorhinolaryngological hospitals of the city of Moscow on the surgical treatment of pharyngeal pathology in adults from 2002 to 2017. It was found that for 16 years surgical treatment of 290 362 patients with ENT-diseases was performed: 181.206 (62. Read More

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http://dx.doi.org/10.17116/otorino20198405132DOI Listing
January 2020

[Pyogenic granuloma on the epiglottis].

Ugeskr Laeger 2019 Oct;181(44)

In this case report, a 78-year-old man presented with dyspnoea, globus sensation and haemoptysis. CT scan and fibre-optic laryngoscopy revealed a 2 × 3 cm tumour on the laryngeal surface of the epiglottis. The tumour was surgically removed by direct laryngoscopy and debulking. Read More

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October 2019

Outcomes of definitive radiotherapy for early laryngeal cancer in terms of survival and patterns of failure.

J Laryngol Otol 2019 Dec 3;133(12):1087-1091. Epub 2019 Dec 3.

Radiation Oncology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Background: Early laryngeal cancer treated with definitive radiotherapy or surgery has a high cure rate. This study evaluated the patterns of treatment failure and long-term results of early laryngeal cancers treated with definitive radiotherapy.

Method: From January 2002 to December 2014, a total of 242 patients with early-stage laryngeal cancers were treated with radical radiotherapy. Read More

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http://dx.doi.org/10.1017/S0022215119002433DOI Listing
December 2019