22,975 results match your criteria Malignant Tumors of the Larynx


On the Merits of Using Angled Fiber Tips in Office-based Laser Surgery of the Vocal Folds.

Proc SPIE Int Soc Opt Eng 2021 Feb 15;11598. Epub 2021 Feb 15.

Dept. of Robotics Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.

Office-based endoscopic laser surgery is an increasingly popular option for the treatment of many benign and pre-malignant tumors of the vocal folds. While these procedures have been shown to be generally safe and effective, recent clinical studies have revealed that there are a number of challenging locations inside the larynx where laser light cannot be easily delivered due to line-of-sight limitations. In this paper, we explore whether these challenges can be overcome through the use of side-firing laser fibers. Read More

View Article and Full-Text PDF
February 2021

Supracricoid laryngectomy: the impact of senescence on swallowing safety.

Einstein (Sao Paulo) 2021 10;19:eAO5715. Epub 2021 May 10.

Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA, Rio de Janeiro, RJ, Brazil.

Objective: To investigate the association between aging and the functional aspects of swallowing (laryngeal penetration and laryngotracheal aspiration) in individuals who underwent supracricoid laryngectomy in the late period and without complaints.

Methods: A total of 70 patients, 56 (80%) aged >60 years and 14 (20%) <60 years, under outpatient follow-up, after cancer treatment and with no complaints of swallowing, performed functional evaluation using the swallowing videofluoroscopy. Image classification was performed using the penetration-aspiration scale developed by Rosenbek. Read More

View Article and Full-Text PDF

Association Between Smoking And Cancers Among Women: Results From The FRiCaM Multisite Cohort Study.

J Cancer 2021 31;12(11):3136-3144. Epub 2021 Mar 31.

Epidemiology Unit, Agency for Health Protection of Milan, Corso Italia 52, 20122, Milan, Italy.

Smoking is one of the leading causes of death worldwide, and it is strongly associated with several human cancers. However, the differential effects of cigarette smoke on the development and progression of different types of cancer remain unclear, and related data are limited. In this longitudinal cohort study conducted among 75,324 women aged 41-76 years, we aimed to evaluate the effect of exposure to tobacco smoke on cancer development. Read More

View Article and Full-Text PDF

The genetic diversity of human papillomavirus types from the species Gammapapillomavirus 15: HPV135, HPV146, and HPV179.

PLoS One 2021 6;16(5):e0249829. Epub 2021 May 6.

Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Ljubljana, Slovenia.

Objectives: To determine the prevalence, viral load, tissue tropism, and genetic variability of novel human papillomavirus (HPV) type 179, which is etiologically associated with sporadic cases of common warts in immunocompromised patients, and phylogenetically related HPV types 135 and 146.

Methods: The representative collection of 850 HPV-associated clinical samples (oral/nasopharyngeal/anal, archival specimens of oral/oropharyngeal/conjunctival/cervical/skin cancer, benign lesions of the larynx/conjunctiva/skin, and eyebrows), obtained from immunocompetent individuals, was tested for the presence of HPV179, HPV135, and HPV146 using type-specific real-time PCRs. To assess the genetic diversity of the HPVs investigated in the non-coding long control region (LCR), several highly sensitive nested PCR protocols were developed for each HPV type. Read More

View Article and Full-Text PDF

A novel surgical approach for hypopharyngeal carcinoma resection via the paraglottic space.

BMC Surg 2021 May 3;21(1):230. Epub 2021 May 3.

Department of Otorhinolaryngology, Qilu Hospital of Shandong University, NHC Key Laboratory of Otorhinolaryngology (Shandong University), 107 Wenhua Xilu, Jinan, 250012, Shandong, China.

Background: Conservative surgery has proven advantageous in controlling hypopharyngeal squamous cell carcinoma (HSCC) and preserving speech and swallowing function in carefully selected patients, typically with early T-stages diseases. A variety of modified surgical procedures or techniques have been proposed.

Methods: In this study, we present a novel surgical approach for hypopharyngeal carcinoma resection utilizing the paraglottic space. Read More

View Article and Full-Text PDF

[A clinical observation of laryngeal ossifying fibromyxoid tumor].

Vestn Otorinolaringol 2021 ;86(2):82-84

Voronezh regional pathoanatomical bureau, Voronezh, Russia.

A rare observation of ossifying fibromyxoid tumor of the larynx in a 23-year-old young man is presented. Surgical intervention, performed in two stages, provided a positive result. With dynamic observation of this patient for three years, continued growth and tumor recurrence were not observed. Read More

View Article and Full-Text PDF

Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas.

Cancers (Basel) 2021 Apr 15;13(8). Epub 2021 Apr 15.

Laboratório de Interações Celulares, Instituto de Ciências Biomédicas, Prédio de Ciências da Saúde-Cidade Universitária, Universidade Federal do Rio de Janeiro-UFRJ, Ilha do Fundão, A. Carlos Chagas, 373-bloco F, sala 26, Rio de Janeiro 21941-902, Brazil.

Head and neck squamous cell carcinomas (HNSCC) are among the most common and lethal tumors worldwide, occurring mostly in oral cavity, pharynx, and larynx tissues. The squamous epithelia homeostasis is supported by the extracellular matrix (ECM), and alterations in this compartment are crucial for cancer development and progression. Laminin is a fundamental component of ECM, where it represents one of the main components of basement membrane (BM), and data supporting its contribution to HNSCC genesis and progression has been vastly explored in oral cavity squamous cell carcinoma. Read More

View Article and Full-Text PDF

Serum Hypoxia Inducible Factor-2: A Candidate Prognostic Biomarker for Laryngeal Cancer.

Clin Otolaryngol 2021 Apr 28. Epub 2021 Apr 28.

Dokuz Eylül University, Institute of Oncology, Izmir, Turkey.

Objectives: To determine the serum hypoxia inducible factor-1, -2 and -3 (HIF-1, -2 and -3) levels in patients with laryngeal neoplasm, and to investigate their role in differential diagnosis, prediction of tumor characteristic and extension, and prognosis and survival.

Study Design: Prospective, cohort study at a tertiary referral center.

Settings: The study was conducted in a tertiary medical centre. Read More

View Article and Full-Text PDF

Estimated incidence of juvenile-onset recurrent respiratory papillomatosis in Korea.

Epidemiol Health 2021 10;43:e2021019. Epub 2021 Mar 10.

Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea.

Objectives: Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 and 11 and is potentially preventable through vaccination. This study estimated the incidence of juvenile-onset RRP before the implementation of the national HPV vaccination program in Korea.

Methods: We conducted a cohort study using claims data provided by a mandatory insurance program to estimate the incidence of RRP and associated healthcare use. Read More

View Article and Full-Text PDF

[Prediction and investigation of the potential risk factors for the upper mediastinal metastasis of papillary thyroid carcinoma].

Zhonghua Zhong Liu Za Zhi 2021 Apr;43(4):477-483

Department of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To predict and investigate the potential risk factors for the upper mediastinal metastasis of papillary thyroid carcinoma (PTC). This study was a prospective cohort study. The admission criteria were patients with untreated thyroid cancer diagnosed in Cancer Hospital, Chinese Academy of Medical Sciences from December 2013 to December 2015, and positive lymph node (cN1, including cN1a and cN1b) was diagnosed by ultrasound. Read More

View Article and Full-Text PDF

Molecular Identification of Human Papillomavirus DNA in Thyroid Neoplasms: Association or Serendipity?

Cureus 2021 Apr 20;13(4):e14578. Epub 2021 Apr 20.

Biomedical Research Unit 02, Specialties Hospital - Western National Medical Center, Mexican Institute of Social Security, Guadalajara, MEX.

Background: Human papillomavirus (HPV) is recognized as the most important cofactor in the etiology of cancers of the cervix, esophagus, larynx, and nasopharynx. Experimental evidence suggests that HPV could have an oncogenic influence on thyroid follicular cells; however, to the best of our knowledge, there is no record of its role in human thyroid gland neoplasms.

Objective: The purpose of this study is to describe the frequency and the types of HPV present in neoplastic thyroid tissue by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Read More

View Article and Full-Text PDF

Epstein-Barr Virus-Associated Smooth Muscle Tumors of Larynx: A Clinicopathologic Study and Comprehensive Literature Review of 12 Cases.

Head Neck Pathol 2021 Apr 23. Epub 2021 Apr 23.

Department of Pathology, Southern California Permanente Medical Group, 5601 De Soto Avenue, Woodland Hills, CA, 91365, USA.

Laryngeal mesenchymal neoplasms are rare, with smooth muscle tumors comprising a small subset. Specifically, Epstein-Barr virus (EBV)-associated smooth muscle tumors are exceptionally rare, lacking a comprehensive evaluation of their clinical and histologic features. Two patients (a 59 year old male and 51 year old female) had received renal transplants 156 and 240 months, respectively prior to onset of laryngeal symptoms. Read More

View Article and Full-Text PDF

Vocal-cord Only vs. Complete Laryngeal radiation (VOCAL): a randomized multicentric Bayesian phase II trial.

BMC Cancer 2021 Apr 22;21(1):446. Epub 2021 Apr 22.

Radiation Oncology Department, Western University, London, Ontario, Canada.

Background: Radiotherapy, along with laser surgery, is considered a standard treatment option for patients with early glottic squamous cell cancer (SCC). Historically, patients have received complete larynx radiotherapy (CL-RT) due to fear of swallowing and respiratory laryngeal motion and this remains the standard approach in many academic institutions. Local control (LC) rates with CL-RT have been excellent, however this treatment can carry significant toxicities include adverse voice and swallowing outcomes, along with increased long-term risk of cerebrovascular morbidity. Read More

View Article and Full-Text PDF

Prevalence of hyposalivation and associated factors in survivors of head and neck cancer treated with radiotherapy.

J Appl Oral Sci 2021 19;29:e20200854. Epub 2021 Apr 19.

Universidade Federal de Santa Maria, Faculdade de Odontologia, Departamento de Patologia, Santa Maria, RS, Brasil.

Hyposalivation and sensation of dry mouth (xerostomia) are one of the most common adverse effects in the treatment of patients with head and neck cancer.

Objective: This study evaluates the prevalence of late hyposalivation and associated factors in survivors of squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx treated with radiotherapy with or without concomitant chemotherapy.

Methodology: A cross-sectional study was conducted with 88 patients who had concluded radiotherapy at least three months before the study, at a referral center for the treatment of head and neck cancer in the Southern region of Brazil. Read More

View Article and Full-Text PDF

Coverage of the hospital-based cancer registries and the designated cancer care hospitals in Japan.

Jpn J Clin Oncol 2021 Apr 14. Epub 2021 Apr 14.

Center for Cancer Registries, Center for Cancer Control and Information Services, National Cancer Center, Japan.

Background: Hospital-based cancer registries were developed to describe and improve clinical care for cancer patients. We described the hospital-based cancer registry coverage as a reference for the users, including researchers, policymakers and clinicians.

Methods: The hospital-based cancer registry coverage was defined as the proportion of new cases registered in the hospital-based cancer registry to the National Cancer Registry as the denominator. Read More

View Article and Full-Text PDF

Sublingual administration of 5-aminolevulinic acid for laser-induced photodiagnostics and photodynamic therapy of oral cavity and larynx cancers.

Photodiagnosis Photodyn Ther 2021 Apr 8;34:102289. Epub 2021 Apr 8.

Prokhorov General Physics Institute of the Russian Academy of Sciences, ul. Vavilova 38, Moscow, 119991, Russia; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute MEPhI), Kashirskoye shosse 31, Moscow, 115409, Russia. Electronic address:

Background: The study aimed to develop a method for sublingual administration of 5-aminolevulinic acid to patients and evaluate its effectiveness in fluorescence diagnostics and photodynamic therapy of neoplasms of the oral cavity and larynx.

Methods: The boundaries of the neoplasms were established by the video-fluorescence diagnostics and clarified using spectral-fluorescent diagnosis before and after photodynamic therapy.

Results: The fluorescence diagnostics demonstrated a high accumulation of protoporphyrin IX, induced by sublingual administration of 5-aminolevulinic acid to patients before the photodynamic therapy and photobleaching of protoporphyrin IX in pathologically altered tissues after the photodynamic therapy. Read More

View Article and Full-Text PDF

Primary laryngeal T-cell lymphoma: A case report and review of the literature.

Int J Surg Case Rep 2021 Apr 2;82:105858. Epub 2021 Apr 2.

University Hassan II Casablanca, Morocco.

Introduction: Primary lymphoma of the larynx is extremely rare, representing less than 1% of all primary laryngeal neoplasms. It consists mainly of non-Hodgkin lymphomas (NHLs), represented particularly by diffuse large B-cell. Extranodal natural killer/T-cell lymphoma, presented in larynx is a rare condition that accounts for less than 11% of all lymphomas without distinctive clinicopathologic features, as well as challenging pathologic diagnosis. Read More

View Article and Full-Text PDF

[Complications of Da Vinci robot thyroid surgery by bilateral axillo-breast approach].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Apr;56(4):363-368

Department of Thyroid and Breast Surgery, the 960th Hospital of the People's Liberation Army of China, Jinan 250031, China.

To evaluate the complications of Da Vinci robotic thyroid surgery by bilateral axillo-breast approach. A retrospective analysis of complications was conducted on 1, 198 cases of Da Vinci robotic thyroid surgery by bilateral axillo-breast approach of the 960 th Hospital of the People's Liberation Army from February 2014 to March 2020. There were 263 men and 935 women, age ranged from 9 to 68 years old, and included 288 benign lesions and 910 malignancies according to preoperative imaging examination, FNAC, and intraoperative frozen pathology. Read More

View Article and Full-Text PDF

Recovering records on cancer of the larynx from anonymous health information databases.

Rev Bras Epidemiol 2021 2;24:e210011. Epub 2021 Apr 2.

Fundação Jorge Duprat Figueiredo de Segurança e Medicina do Trabalho, Ministry of Economy - São Paulo (SP), Brazil.

Objective: To develop a linkage algorithm to match anonymous death records of cancer of the larynx (ICD-10 C32X), retrieved from the Mortality Information System (SIM) and the Hospital Information System of the Brazilian Unified National Health System (SIH-SUS) in Brazil.

Methodology: Death records containing ICD-10 C32X codes were retrieved from SIM and SIH-SUS, limited to individuals aged 30 years and over, between 2002 and 2012, in the state of São Paulo. The databases were linked using a unique key identifier developed with sociodemographic data shared by both systems. Read More

View Article and Full-Text PDF

[Applied value of color Doppler flow imaging in diagnosis of congenital subglottic haemangioma in infant].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Apr;35(4):321-324

Department of Otolaryngology,Qilu Children's Hospital of Shandong University,Ji'nan,250022,China.

To investigate the value of color Doppler flow imaging(CDFI) in the diagnosis of congenital subglottic hemangioma(CSH) in infants. The data of 18 children with CSH who underwent laryngeal CDFI examination were collected and analyzed retrospectively, and compared with those who underwent laryngeal ultrasound examination at the same time. The shape, size, blood flow characteristics of the tumor and its relationship with airway were observed. Read More

View Article and Full-Text PDF

[Pathologic tumor volume predicting survival outcomes of patients with local advanced glottic carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Apr;35(4):316-320

Department of Otolaryngology Head and Neck Surgery,Eye & ENT Hospital of Fudan University,Shanghai,200031,China.

The aim of this study was to evaluate the predicting role of tumor volume as evaluated by postoperative pathologic examination on overall survival(OS) and disease free survival(DFS) in patients with local advanced glottic carcinoma. In this study, the records of 406 consecutive patients with local advanced glottic carcinoma(T3-T4 stages) who underwent surgery ± chemoradiotherapy from January 2005 to December 2010 were retrospectively reviewed and followed up. The demographic characteristics, disease staging, and pathologic tumor volume were analyzed. Read More

View Article and Full-Text PDF

[Clinical analysis of 15 cases of laryngeal schwannoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Mar;35(3):256-259

Department of Otorhinolaryngology Head and Neck Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,450052,China.

To improve the diagnosis and treatment of laryngeal schwannoma. The clinical data of 15 patients with laryngeal schwannoma were retrospectively analyzed, including 5 male patients and 10 female patients. The tumors were located in aryepiglottic fold in 4 cases, arytenoid region in 4 cases, interarytenoid in 2 cases, false vocal cord in 2 cases, epiglottis in 1 case, vocal cord in 1 case, and subglottic region in 1 case. Read More

View Article and Full-Text PDF

Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.

Lancet Oncol 2021 04;22(4):450-462

Moores Cancer Center, UC San Diego Health, La Jolla, CA, USA.

Background: Chemoradiotherapy is the standard of care for unresected locally advanced squamous cell carcinoma of the head and neck. We aimed to assess if addition of avelumab (anti-PD-L1) to chemoradiotherapy could improve treatment outcomes for this patient population.

Methods: In this randomised, double-blind, placebo-controlled, phase 3 study, patients were recruited from 196 hospitals and cancer treatment centres in 22 countries. Read More

View Article and Full-Text PDF

Induction Chemotherapy Plus Simultaneous Modulated Accelerated Radiation Therapy in Non-operative Hypopharyngeal and Supraglottic Laryngeal Squamous Cell Carcinoma: Long-Term Outcome of a Prospective Phase 2 Study.

Front Oncol 2021 12;11:637978. Epub 2021 Mar 12.

Department of Radiation Oncology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.

To evaluate the toxicities and long-term outcomes of induction chemotherapy (ICT) plus simultaneous modulated accelerated radiation therapy (SMART) in non-operative hypopharyngeal and supraglottic laryngeal squamous cell carcinoma (SCCH/L). This was a prospective phase 2 study. Patients diagnosed with SCCH/L, aged from 18 to 75, staged from III to IVB in accordance with the AJCC 2010 criteria, and refusing surgery were eligible. Read More

View Article and Full-Text PDF

Potassium-Titanyl-Phosphate (KTP) Laser Photocoagulation Combined with Resection Using an Ultrasonic Scalpel for Pharyngolaryngeal Hemangioma via a Transoral Approach: Case Report and Literature Review.

Am J Case Rep 2021 Mar 23;22:e931042. Epub 2021 Mar 23.

Department of Otorhinolaryngology-Head and Neck Surgery, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.

BACKGROUND Hemangiomas are relatively rare, slow-growing, benign neoplasms that can cause necrosis, ulceration, and infection leading to airway obstruction or intractable hemorrhage. Controversy persists regarding the treatment options for these tumors, which include active observation, corticosteroids, sclerotherapy, laser treatment, and surgical resection. CASE REPORT A 61-year-old man presented with a 6-month history of persistent throat clearing and foreign body sensation in the throat. Read More

View Article and Full-Text PDF

Pericardial metastasis of parotid mucoepidermoid carcinoma diagnosed by pericardial biopsy.

Auris Nasus Larynx 2021 Mar 6. Epub 2021 Mar 6.

Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1, Shinjuku-ku, Tokyo, Nishishinjuku 160-0023, Japan.

A 30-year-old man presented with swelling in the lower left ear. Close examination led to a diagnosis of parotid gland cancer, T4N0M0 Stage IVA, so total resection of the left parotid gland and left neck dissection were performed. Pathological examination led to a diagnosis of high-grade malignant-type mucoepidermoid, and chemoradiotherapy was performed as postoperative treatment. Read More

View Article and Full-Text PDF

[Neoplasms of the upper respiratory tract and ear].

Vestn Otorinolaringol 2021 ;86(1):96-102

Central Clinical Hospital No. 2 named after N.N. Semashko, Moscow, Russia.

Neoplasms of the upper respiratory tract and ear are tumors of visual localization; however, patients often go to specialized medical institutions in the presence of a widespread tumor process. This paper presents a brief overview of the most common benign and malignant tumors with localization in the oropharynx, nasopharynx, larynx and ear. The clinical picture, diagnosis and various treatment options are presented. Read More

View Article and Full-Text PDF

Early glottic cancer recurrence: A critical review on its current management.

Crit Rev Oncol Hematol 2021 Apr 11;160:103298. Epub 2021 Mar 11.

Department of Otorhinolaryngology, Careggi University Hospital, Largo Brambilla 3, 50134, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Introduction: Recurrent early glottic cancer (rEGC) poses several issues in terms of timely diagnosis, correct re-staging, and treatment. We want to critically review the latest evidence about rEGC considering its epidemiology, biology, diagnostic challenges, and treatment strategies.

Methods: A systematic search of the literature using PubMed from 1990 to October 31, 2020 was performed. Read More

View Article and Full-Text PDF

Lymph node yield in treatment naïve cases of head and neck squamous cell carcinoma: en bloc lymphadenectomy versus level-by-level dissection.

J Laryngol Otol 2021 Apr 15;135(4):359-366. Epub 2021 Mar 15.

Department of Pathology, Kasturba Medical College and Hospital, Manipal, Manipal Academy of Higher Education, Udupi, India.

Background: Lymph node yield is an important prognostic factor in head and neck squamous cell carcinoma. Variability in neck dissection sampling techniques has not been studied as a determinant of lymph node yield.

Methods: This retrospective study used lymph node yield and average nodes per level to compare level-by-level and en bloc neck dissection sampling methods, in primary head and neck squamous cell carcinoma cases operated between March 2017 and February 2020. Read More

View Article and Full-Text PDF

Perineural Invasion As the Sole Pathologic Risk Factor After Surgical Resection for Head and Neck Squamous Cell Carcinoma.

Cureus 2021 Feb 3;13(2):e13094. Epub 2021 Feb 3.

Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, USA.

Introduction Postoperative radiotherapy (PORT) is routinely recommended for patients with head and neck squamous cell carcinoma (HNSCC) based on pathologic risk factors (pRFs) such as perineural invasion (PNI). Patients with PNI as the sole pRF after resection of HNSCC are uncommon and their prognosis is less clear. The aim of this study is to assess the role of PNI as a sole risk factor in patients with otherwise pathologically low-risk HNSCC. Read More

View Article and Full-Text PDF
February 2021