21,733 results match your criteria Malignant Tumors of the Larynx


The impact of reducing alcohol consumption in Australia: an estimate of the proportion of potentially avoidable cancers 2013-2037.

Int J Cancer 2019 Feb 12. Epub 2019 Feb 12.

Population Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland 4006, Australia.

The International Agency for Research on Cancer first concluded that alcohol causes cancer in humans in 1988. The World Cancer Research Fund has declared that alcohol causes cancer of the oral cavity, pharynx, larynx, oesophagus (squamous cell carcinoma), female breast, colon, rectum, stomach and liver. It recommended that alcohol be avoided altogether to prevent cancer. Read More

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http://dx.doi.org/10.1002/ijc.32204DOI Listing
February 2019
2 Reads

Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy.

Auris Nasus Larynx 2019 Feb 7. Epub 2019 Feb 7.

Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

As has been well recognized, methotrexate (MTX) leads to a state of immunosuppression and can provide a basis for the development of lymphoproliferative disorders (LPDs). MTX-associated LPDs can affect nodal sites as well as extranodal sites, though the manifestation of an LPD in the form of multiple pulmonary nodules is rare. Here, we report two cases of MTX-associated LPD with multiple bilateral pulmonary nodules, which was a finding suggestive of lung cancer, and bilateral cervical lymphadenopathy. Read More

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http://dx.doi.org/10.1016/j.anl.2019.01.010DOI Listing
February 2019

Prevalence of Fatigue in Head and Neck Cancer Survivors.

Ann Otol Rhinol Laryngol 2019 Jan 30:3489419826138. Epub 2019 Jan 30.

2 Supportive Care Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Introduction:: In head and neck cancer (HNC) patients, fatigue is present throughout the course of treatment and during follow-up. There are limited data about the prevalence and factors associated with fatigue in HNC survivors. The objectives of this study were to assess the prevalence of fatigue and its interference with daily life activities and examine the association between fatigue and gender, age, primary tumour site, Human Papillomavirus (HPV) status, previous oncologic therapy, and time since end of treatment. Read More

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http://dx.doi.org/10.1177/0003489419826138DOI Listing
January 2019
2 Reads

Free bipaddled anterolateral thigh flap for simultaneous reconstruction of large larynx and prelaryngeal skin defects after resection of the local recurrent laryngeal cancer invading the cricoid cartilage and prelaryngeal skin: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14199

Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

Rationale: After total or near-total laryngectomy and resection of prelaryngeal skin, laryngeal defects and prelaryngeal skin defects often remain a great challenge for head and neck surgeons when considering simultaneous reconstruction of. In this case report, a free bipaddled anterolateral thigh (ALT) was used for such defects reconstruction.

Patient Concerns: For this 50-year-old male patient whose recurrent tumor invaded the cricoid cartilage and the prelaryngeal skin, supracricoid partial laryngectomy with a cricohyoidepiglottopexy would no longer be an option. Read More

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http://dx.doi.org/10.1097/MD.0000000000014199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358393PMC
January 2019
1 Read
5.723 Impact Factor

Prevalence of human papillomavirus-related diseases in the Republic of Korea: a cross-sectional study.

Sex Transm Infect 2019 Jan 24. Epub 2019 Jan 24.

Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea

Objective: We aimed to evaluate trends in the prevalence of human papillomavirus (HPV)-related diseases in the era before the introduction of organised HPV vaccination programmes in the Republic of Korea.

Methods: This cross-sectional study used National Health Insurance Service data from 2002 to 2015 and included participants who were diagnosed with the following HPV-related diseases (codes from the International Classification of Diseases, 10th Revision): genital warts (A63.0); cancer in the head and neck (C00-C10), anus (C21), vulva (C51), vagina (C52), cervix uteri (C53) and penis (C60); carcinoma in situ (CIS) of the lip/oral cavity/pharynx (D00. Read More

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http://sti.bmj.com/lookup/doi/10.1136/sextrans-2018-053742
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http://dx.doi.org/10.1136/sextrans-2018-053742DOI Listing
January 2019
4 Reads

Cluster of differentiation 8 T-cell population in the laryngeal mucosa of smokers with laryngeal cancer.

J Laryngol Otol 2018 Dec;132(12):1134-1137

Department of Otolaryngology,Cairo Police Hospital,Egypt.

Objective: To study the cluster of differentiation 8 population in the laryngeal mucosa of patients with laryngeal carcinoma. To our knowledge this is the first paper to address this issue.

Methods: The study group included 40 patients with known laryngeal cancer who were scheduled for laryngectomy. Read More

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http://dx.doi.org/10.1017/S0022215118002244DOI Listing
December 2018

[Primary mucinous adenocarcinoma of the larynx: a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;33(1):80-81

Mucinous adenocarcinoma is most commonly found in the digestive tract,and the prognosis is poor.We present here a case of primary mucinous adenocarcinoma of the larynx, which is an extremely rare entity and very few have been reported in the literature.A 72-year-old male complained of intermittent hoarseness for over 2 months of duration. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.01.017DOI Listing
January 2019
1 Read

Long-term Survival in Head and Neck Cancer: Impact of Site, Stage, Smoking, and Human Papillomavirus Status.

Laryngoscope 2019 Jan 13. Epub 2019 Jan 13.

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri, U.S.A.

Objectives/hypothesis: Literature examining long-term survival in head and neck squamous cell carcinoma (HNSCC) with human papillomavirus (HPV) status is lacking. We compare 10-year overall survival (OS) rates for cases to population-based controls.

Study Design: Prospective cohort study. Read More

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http://doi.wiley.com/10.1002/lary.27807
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http://dx.doi.org/10.1002/lary.27807DOI Listing
January 2019
11 Reads

Genome-Wide Analysis of Head and Neck Squamous Cell Carcinomas Reveals HPV, TP53, Smoking and Alcohol-Related Allele-Based Acquired Uniparental Disomy Genomic Alterations.

Neoplasia 2019 02 4;21(2):197-205. Epub 2019 Jan 4.

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR; Precision Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.

Smoking and alcohol intake are major risk factors in head and neck squamous cell carcinomas (HNSCCs). Although the link between TP53 mutation and smoking has been well established, very little is known about the link between acquired uniparental disomy (aUPD) and smoking and/or alcohol consumption or other clinical characteristics. We used TCGA genomic data to investigate whether smoking, alcohol intake, clinical and demographic variables, HPV status and TP53 mutation are associated with aUPD at specific chromosomal regions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14765586183060
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http://dx.doi.org/10.1016/j.neo.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321975PMC
February 2019
1 Read

Mortality among workers exposed to asbestos at the shipyard of Genoa, Italy: a 55 years follow-up.

Environ Health 2018 12 29;17(1):94. Epub 2018 Dec 29.

Clinical Epidemiology, Ospedale Policlinico San Martino-IRCCS, Istituto di Ricovero e Cura a Carattere Scientifico per l'Oncologia, Genoa, Italy.

Background: Exposure to asbestos remains a global issue due to its massive use in the twentieth century and its long environmental persistence. Exposure to asbestos still occurs during dismantling of ships and vessels, buildings renovation, mining operations, and is reported in developing countries. Current estimate report exposure of hundreds of million people in occupational settings in countries where its use remains unregulated. Read More

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http://dx.doi.org/10.1186/s12940-018-0439-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310930PMC
December 2018
2 Reads

Adenoid cystic carcinoma in ventricle of larynx: An interesting case.

Medicine (Baltimore) 2018 Dec;97(50):e13622

Department of Otolaryngology, First Affiliated Hospital, College of Medicine, Zhe Jiang University, Hangzhou.

Rationale: Adenoid cystic carcinomas (ACCs) are malignant tumors and occur in the major and the minor salivary glands. ACCs are rare in the larynx.

Patient Concerns: A 55-year-old female patient who presented with a 12 months history of paraesthesia pharynges and hoarseness for 4 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000013622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320204PMC
December 2018
2 Reads

The management of mid & proximal oesophageal squamous cell carcinoma.

Authors:
Ian Wong Simon Law

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:85-90. Epub 2018 Nov 30.

Division of Esophageal and Upper Gastrointestinal Surgery, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong. Electronic address:

Despite the rise in incidence of adenocarcinoma, squamous cell cancer of the oesophagus remains the commonest cell type worldwide and is predominant in the East. Except for very early tumours where endoscopic therapy can be performed with curative intent, in more advanced but potentially curative cancers, treatment for mid and upper third tumours is primarily surgery with extended lymphadenectomy, together with multimodal therapies such as preoperative chemotherapy or chemoradiotherapy. Definitive chemoradiotherapy is utilized in those who decline surgery or in those who are unfit for major procedures. Read More

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http://dx.doi.org/10.1016/j.bpg.2018.11.012DOI Listing
January 2019
3.478 Impact Factor

[Advances in prevention of pharyngocutaneous fistula after total laryngectomy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1917-1922

Total laryngectomy is a common method for the treatment of malignant tumors of the pharynx and larynx in China, but pharyngocutaneous fistula often happens after surgery, which burdens patients and affects postoperative recovery. At present, there are many measures to prevent pharyngocutaneous fistula, including strengthening nutrition pre-operative and post-operative, testing related indicators, controlling comorbidities, rational use of drugs, regular oral care, optimal selection of incision closure, and using of flaps and special materials during operation, etc. However, the choice of specific program needs to take care of the patient's condition, surgeon's skills and hospital conditions, and often requires multiple programs to be used together throughout the perioperative period. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.24.018DOI Listing
December 2018
6 Reads

Symmetrical Apophyses on the Posterior Margins of the Thyroid Cartilage: A Previously Undescribed Anatomical Variation With Potential Forensic Implications.

Am J Forensic Med Pathol 2019 Mar;40(1):84-88

Departamento de Anatomía y Embriología Humana Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.

Differential diagnosis between normal/variant anatomy and pathological/traumatic findings represents one of the main matters of investigation of the so-called forensic clinical anatomy. In the literature, many anatomical variations of the laryngeal thyroid cartilage have been reported, with potential implications in forensic pathology. They include triticeal cartilages, foramen thyroideum, asymmetry, segmentation or agenesis of the superior thyroid horns, bone connections with the hyoid bone, absence of cricothyroid facets, hypertrophy of the inferior thyroid tubercle, and asymmetries in the thyroid notch, isthmus, or length of the inferior horn. Read More

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http://Insights.ovid.com/crossref?an=00000433-900000000-9917
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http://dx.doi.org/10.1097/PAF.0000000000000452DOI Listing
March 2019
3 Reads

Outcomes of Treating Early Glottic Neoplasms With a Potassium Titanyl Phosphate Laser.

Ann Otol Rhinol Laryngol 2019 Feb 11;128(2):85-95. Epub 2018 Dec 11.

2 Auckland City Hospital, Auckland, New Zealand.

Objectives:: The aim of this study was to assess the outcome of treating glottic dysplasia and early squamous cell carcinoma (SCC) with potassium titanyl phosphate (KTP) photoangiolytic laser ablation.

Methods:: Patient demographics, comorbidities, and tumor characteristics were recorded. Perceptual, patient-reported, and objective voice outcomes were assessed. Read More

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http://dx.doi.org/10.1177/0003489418806914DOI Listing
February 2019
5 Reads

Tuberculous neck lymphadenopathy: A diagnostic challenge.

J Stomatol Oral Maxillofac Surg 2018 Dec 1. Epub 2018 Dec 1.

Division of Maxillofacial Surgery, University of Eastern Piedmont, Novara, Italy.

Tuberculosis (TB) continues to be a major health problem for the developing world and a rise in the number of cases has been noted in the western hemisphere too. TB can affect most organs in the head and neck region, such as the lymph nodes, larynx, middle ear, oral cavity and pharynx. In particular, as for cervical tuberculosis lymphadenopathy, a predominant involvement of the posterior triangle, supraclavicular, and internal jugular group of nodes bilaterally can be observed. Read More

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http://dx.doi.org/10.1016/j.jormas.2018.11.012DOI Listing
December 2018
6 Reads

Prophylaxis with oral zinc sulfate against radiation-induced oropharyngeal mucositis in patients with head and neck cancer: Protocol for a meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2018 Nov;97(48):e13310

Department of Nursing, Peking University of Stomatology Hospital, Beijing.

Background: Oropharyngeal mucositis is considered to be an inevitable and the most troubling side effect of head and neck irradiation, which is caused by the direct toxic action of radiation on oral mucosa. Several randomized controlled trials (RCTs) have investigated the efficacy of zinc sulfate in prevention of radiation-induced oropharyngeal mucositis in patients with head and neck cancer. However, the definite conclusions have not been confirmed. Read More

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http://dx.doi.org/10.1097/MD.0000000000013310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283232PMC
November 2018
12 Reads

Dosimetric impact of Acuros XB dose-to-water and dose-to-medium reporting modes on VMAT planning for head and neck cancer.

Phys Med 2018 Nov 15;55:107-115. Epub 2018 Nov 15.

Department of Medical Sciences, University of Girona, C/Emili Grahit 77, 17003 Girona, Spain; Department of Radiology, Clínica Girona, Institut de Diagnòstic per la Imatge, C/Lorenzana 36, 17002 Girona, Spain. Electronic address:

Purpose: To assess the dosimetric impact of switching from the Analytical Anisotropic Algorithm (AAA) to Acuros XB (AXB) for both dose-to-medium (Dm) and dose-to-water (Dw) in VMAT for H&N patients. To study whether it should be linked to a change in the dose prescriptions to the PTVs and in the constraints to the OARs.

Methods: 110H&N patients treated with VMAT were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11201797183131
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http://dx.doi.org/10.1016/j.ejmp.2018.10.024DOI Listing
November 2018
11 Reads

Narrow band imaging in transoral laser microsurgery (TLM) in moderately advanced (T2, T3) glottic cancer.

Otolaryngol Pol 2018 Aug;72(5):17-23

Department of Otolaryngology, Head and Neck Surgery, Poznań University of Medical Sciences, Poznań, Poland.

Introduction: Treatment planning in T2, T3 laryngeal carcinoma is based on clinical assessment and radiological imaging. However, to delineate precise mucosal margins for transoral laser microsurgery (TLM), a high class, sophisticated endoscopy is indispensable. Narrowband imaging (NBI) which is an optical filter technology, seems to be a useful adjunctive tool in marking superficial margins. Read More

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http://dx.doi.org/10.5604/01.3001.0012.0486DOI Listing
August 2018
14 Reads

Immunohistochemical analysis of vocal cord polyps applying markers of squamous cell carcinogenesis.

Pathol Res Pract 2019 Jan 10;215(1):144-150. Epub 2018 Nov 10.

Faculty of Medicine, University of Rijeka, Rijeka, Croatia.

Objective: The aim of the study was to perform a pathohistological and immunohistochemical analysis of squamous cell (SC) carcinogenesis markers on epithelial linings of vocal cord polyps. The vocal box, being a heavily burdened organ with intensive cell renewal and regenerative processes, is therefore a favourable environment for constant epithelial growth and hyperplasia. In our ongoing projects on laryngeal carcinogenesis and research on laryngeal tissue, we encountered atypia on diagnosed nodules and polyps that are usually considered as benign formations, resulting from the above-mentioned cell renewal and regeneration, which lead to further investigation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03440338183131
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http://dx.doi.org/10.1016/j.prp.2018.11.001DOI Listing
January 2019
11 Reads

[Tiempo de respuesta terapéutica al propranolol sistémico en el manejo de hemangiomas subglóticos pediátricos: serie de casos y revisión de la literatura].

Bol Med Hosp Infant Mex 2018 ;75(6):377-382

Departamento de Otorrinolaringología Pediátrica. Hospital Infantil de México Federico Gómez, Ciudad de México, México.

Background: Airway hemangiomas are congenital neoplasms of low incidence. Its clinical presentation consists of obstruction of the upper airway with progressive dyspnea and stridor and the life of the patient at risk. Infantile hemangiomas have an incidence at birth of 2%, increasing to 9% at 12 months of life. Read More

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http://www.bmhim.com/files/bmhi_2018_6_377-382.pdf
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http://dx.doi.org/10.24875/BMHIM.18000043DOI Listing
January 2018
8 Reads

Relation of baseline neutrophil-to-lymphocyte ratio to survival and toxicity in head and neck cancer patients treated with (chemo-) radiation.

Radiat Oncol 2018 Nov 6;13(1):216. Epub 2018 Nov 6.

Department of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.

Background: A high neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation and together with the platelet-to-lymphocyte ratio (PLR) is associated with worse outcomes in several solid tumors. We investigated the prognostic value of NLR and PLR in patients with head and neck squamous cell carcinoma (HNSCC) treated with primary or adjuvant (chemo)radiotherapy ((C)RT).

Methods: A retrospective chart review of consecutive patients with HNSCC was performed. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
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http://dx.doi.org/10.1186/s13014-018-1159-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219022PMC
November 2018
5 Reads

Structural biology of intraepithelial neuroendocrine cells in the larynx: Literature review.

Pathol Res Pract 2019 Jan 24;215(1):1-4. Epub 2018 Oct 24.

Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

Current knowledge of laryngeal neuroendocrine cells in man and other vertebrates is reviewed. Particular attention is paid to differences in the distribution of neuroendocrine cells between squamous and respiratory laryngeal mucosa, foetal versus post-natal spatial arrangements, relation to the laryngeal cavity and nerve fibres, and immunoreactivities of these cells. Methodological deficiencies and gaps in knowledge are outlined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03440338183107
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http://dx.doi.org/10.1016/j.prp.2018.10.027DOI Listing
January 2019
5 Reads

Human papillomavirus in head and neck squamous cell carcinomas in a South African cohort.

Papillomavirus Res 2018 12 1;6:58-62. Epub 2018 Nov 1.

Department of Otorhinolaryngology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Department of Otorhinolaryngology, Universitas Academic Hospital, Bloemfontein, South Africa. Electronic address:

Background: Most tumours of the head and neck are attributable to smoking and alcohol use, but an increasing proportion of head and neck tumours are caused by human papillomaviruses (HPVs). The aim of this study was to use in house molecular assays to detect and genotype HPV in biopsies from patients with histologically confirmed head and neck squamous cell carcinomas. In addition, the results were compared with p16 immunohistochemistry staining, which has been described as a potential marker for HPV infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058521183004
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http://dx.doi.org/10.1016/j.pvr.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232649PMC
December 2018
7 Reads

Multiple Cutaneous Metastases on TC-HYNIC-TOC Scan in a Rare Case of Malignant Laryngeal Paraganglioma.

Indian J Nucl Med 2018 Oct-Dec;33(4):348-350

Department of Nuclear Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Laryngeal paraganglioma is a rare neuroendocrine tumor arising from neural crest cells of larynx, contributing to 0.6% of the laryngeal tumors. Patients usually present with compressive symptoms such as hoarseness of voice. Read More

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http://dx.doi.org/10.4103/ijnm.IJNM_54_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194765PMC
November 2018
4 Reads

Surveillance for Cancers Associated with Tobacco Use - United States, 2010-2014.

MMWR Surveill Summ 2018 11 2;67(12):1-42. Epub 2018 Nov 2.

Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC.

Problem/condition: Tobacco use is the leading preventable cause of cancer, contributing to at least 12 types of cancer, including acute myeloid leukemia (AML) and cancers of the oral cavity and pharynx; esophagus; stomach; colon and rectum; liver; pancreas; larynx; lung, bronchus, and trachea; kidney and renal pelvis; urinary bladder; and cervix. This report provides a comprehensive assessment of recent tobacco-associated cancer incidence for each cancer type by sex, age, race/ethnicity, metropolitan county classification, tumor characteristics, U.S. Read More

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http://www.cdc.gov/mmwr/volumes/67/ss/ss6712a1.htm?s_cid=ss6
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http://dx.doi.org/10.15585/mmwr.ss6712a1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220819PMC
November 2018
2 Reads

Acceptable Weight Ranges for Research Tissue Procurement and Biorepositories, 2015-2017.

Biopreserv Biobank 2018 Oct 31. Epub 2018 Oct 31.

1 Ohio Consortium , Cooperative Human Tissue Network (CHTN) Midwestern Division, Columbus, Ohio.

Background: The Cooperative Human Tissue Network, Midwestern Division, is a National Cancer Institute-funded program that provides quality research biospecimens to qualified investigators. Consented human tissues are procured according to researcher specifications for weight (size) and preservation type; weights of samples in significant demand and limited supply are negotiated. Weights of procured tissues are entered into a dedicated biospecimen database. Read More

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http://dx.doi.org/10.1089/bio.2018.0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308276PMC
October 2018
3 Reads

Laryngeal reconstruction in children with recurrent respiratory papillomatosis.

Int J Pediatr Otorhinolaryngol 2018 Dec 28;115:120-124. Epub 2018 Sep 28.

Department of Respiratory Endoscopy, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.

Objetives: To describe our experience in reconstructive laryngeal surgery in patients with recurrent respiratory papillomatosis (RRP).

Introduction: RRP is a rare laryngeal disease requiring multiple surgical endoscopic interventions during its course. These interventions may cause secondary lesions that may compromise airway patency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183049
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http://dx.doi.org/10.1016/j.ijporl.2018.09.028DOI Listing
December 2018
18 Reads

Application of lateral tarsoconjunctival flap to correct ocular complications of Madelung's disease: A case report and literature review.

Medicine (Baltimore) 2018 Oct;97(42):e12864

Department of Ophthalmology, Tri-Service General Hospital.

Rationale: Madelung's disease is a specific type of benign symmetric lipomatosis, which is characterized by overgrowing fat distributed at the neck and shoulder. This excessive fat accumulation may occur in different regions, including vital organs, such as the larynx, trachea, or the orbits. Surgery is usually performed to correct the esthetic or functional concern of the affected area. Read More

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http://dx.doi.org/10.1097/MD.0000000000012864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211917PMC
October 2018
13 Reads

Survival of patients with head and neck cancer treated with definitive radiotherapy and concurrent cisplatin or concurrent cetuximab: A Surveillance, Epidemiology, and End Results-Medicare analysis.

Cancer 2018 Dec 17;124(23):4486-4494. Epub 2018 Oct 17.

Department of Radiation Oncology, Stanford University, Stanford, California, United States.

Background: Cisplatin and cetuximab are both systemic therapies commonly used in combination with radiation (RT) for the definitive treatment of head and neck cancers, but their comparative efficacy is unclear.

Methods: Patients with locoregionally advanced (American Joint Committee on Cancer stage III-IVB) squamous cell carcinomas of the oropharynx, larynx, or hypopharynx were identified in the Surveillance, Epidemiology, and End Results-Medicare database. Patients received either cisplatin or cetuximab concurrent with RT, as determined by Medicare claims. Read More

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http://dx.doi.org/10.1002/cncr.31708DOI Listing
December 2018

The role of induction chemotherapy followed by surgery in unresectable stage IVb laryngeal and hypopharyngeal cancers: a case series.

J Otolaryngol Head Neck Surg 2018 Oct 16;47(1):62. Epub 2018 Oct 16.

Department of Otolaryngology, Chiang Mai University, Chiang Mai, 50200, Thailand.

Background: The purpose of this study was to evaluate the benefit of induction chemotherapy followed by surgery in locally advanced unresectable stage IVb laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC).

Methods: Data of patients with stage IVb LHSCC who received induction chemotherapy for the purpose of tumor resection between January 2007 and January 2016 were retrospectively collected. Definitive surgery with postoperative adjuvant therapy was performed in patients whose tumors became resectable (resectable group). Read More

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https://journalotohns.biomedcentral.com/articles/10.1186/s40
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http://dx.doi.org/10.1186/s40463-018-0310-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192312PMC
October 2018
9 Reads

Single cell RNA-seq reveals profound transcriptional similarity between Barrett's oesophagus and oesophageal submucosal glands.

Nat Commun 2018 10 15;9(1):4261. Epub 2018 Oct 15.

Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.

Barrett's oesophagus is a precursor of oesophageal adenocarcinoma. In this common condition, squamous epithelium in the oesophagus is replaced by columnar epithelium in response to acid reflux. Barrett's oesophagus is highly heterogeneous and its relationships to normal tissues are unclear. Read More

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http://dx.doi.org/10.1038/s41467-018-06796-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189174PMC
October 2018
26 Reads

[Clinical analysis of malignant salivary gland tumors of the larynx].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;53(9):684-687

Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai 200031, China.

To evaluate the clinical features, treatments and prognoses of malignant salivary gland tumors of the larynx. A total of 14 patients with malignant salivary gland tumors of the larynx diagnosed and treated in our hospital between 2003 and 2014 were analyzed retrospectively, and were compared with 62 patients from the Surveillance, Epidemiology, and End (SEER) database of American for survival rates. Results Among 14 patients from our hospital, 9 males and 5 females, with a median of 66. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2018.09.009DOI Listing
September 2018
15 Reads

[Primary laryngeal Non-Hodgkin' s lymphoma: a case report].

Authors:
Q R Chen H Yang D Lv

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Aug;32(15):1196-1198

Non-Hodgkin' s lymphoma is a kind of disease which might manifest in varied form. Unlike squamous cell carcinoma, the majority of laryngeal tumors, non-Hodgkin' s lymphoma in larynx is extremely rare. Here we present a primary laryngeal non-Hodgkin' s lymphoma, a 66-year-old female, with a history of recurrent sore throat and hoarseness for over 1 year. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.15.0018DOI Listing
August 2018
14 Reads

MiR-410 affects the proliferation and apoptosis of lung cancer A549 cells through regulation of SOCS3/JAK-STAT signaling pathway.

Eur Rev Med Pharmacol Sci 2018 Sep;22(18):5994-6001

Department of Physical Examination Center, Jinan Central Hospital affiliated to Shandong University, Jinan, Shandong, China.

Objective: Larynx carcinoma is a common head-neck malignant tumor. Recent investigations showed the involvement of microRNA (miR) in regulation of multiple tumors. miR-140-5p showed decreased expression in various cancers, but without knowledge regarding its expression in larynx carcinoma and effects on cell invasion and angiogenesis. Read More

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http://dx.doi.org/10.26355/eurrev_201809_15934DOI Listing
September 2018
7 Reads

A comparison of phonatory outcome between trans-oral CO Laser cordectomy and radiotherapy in T1 glottic cancer.

Eur Arch Otorhinolaryngol 2018 Nov 29;275(11):2783-2786. Epub 2018 Sep 29.

Voice Clinic, Deenanath Mangeshkar Hospital, Pune, India.

Purpose: This study aimed at comparing phonatory outcomes between Trans-oral Laser Surgery and Radiotherapy in T1 glottic cancer.

Introduction: Early glottic carcinoma, i.e. Read More

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http://dx.doi.org/10.1007/s00405-018-5152-8DOI Listing
November 2018

Prevalence of neoplasms in patients with acromegaly - the need for a national registry.

Ann Agric Environ Med 2018 Sep 16;25(3):559-561. Epub 2018 Apr 16.

Department of Epidemiology and Clinical Research Methodology, Medical University, Lublin, Poland.

Introduction: Acromegaly is an endocrine disorder caused predominantly by pituitary adenoma leading to autonomic oversecretion of growth hormone and secondary elevation of insulin-like growth factor 1 (IGF-1). Consequently, there are both theoretical and experimental grounds for establishing a correlation between this disorder and the higher incidence of neoplasms.

Objective: The aim of the study is to evaluate the incidence and types of neoplasms among patients with acromegaly. Read More

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http://dx.doi.org/10.26444/aaem/85652DOI Listing
September 2018
2 Reads

Presence of Helicobacter Pylori in the Stomach and Laryngeal Mucosal Linings in Patients with Laryngeal Cancer.

Acta Clin Croat 2018 Mar;57(1):91-95

Department of ENT and Head and Neck Surgery, Vukovar General Hospital, Vukovar, Croatia.

Helicobacter (H.) pylori is the cause of one of the most common chronic bacterial infections in humans. Risk factors for the development of laryngeal cancer are cigarette smoke, alcohol, and human papillomavirus. Read More

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http://dx.doi.org/10.20471/acc.2018.57.01.10DOI Listing
March 2018
14 Reads

Risk factors for cervical lymph node metastasis in endoscopically resected superficial hypopharyngeal cancers.

Auris Nasus Larynx 2018 Sep 21. Epub 2018 Sep 21.

Department of Head and Neck Surgery, Miyagi Cancer Center, Natori, Miyagi, Japan.

Objective: Hypopharyngeal cancer is a head and neck cancer with a poor prognosis, and most cases show metastases on diagnosis. Cervical lymph node (LN) metastasis is a poor prognostic factor in hypopharyngeal cancer patients. The identification of risk factors for LN metastasis can help guide surgical treatment strategies for these patients. Read More

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http://dx.doi.org/10.1016/j.anl.2018.09.005DOI Listing
September 2018
1 Read

Personalizing Postoperative Treatment of Head and Neck Cancers.

Am Soc Clin Oncol Educ Book 2018 May(38):515-522

From the Division of Head and Neck Surgery, City of Hope National Medical Center, Duarte, CA; Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH; Department of Medical Oncology, University of North Carolina Hospitals, Chapel Hill, NC.

Head and neck cancer (HNC) treatment is a complex multidisciplinary undertaking. Although overtreatment can result in functional and cosmetic defects, undertreatment can result in cancer recurrence. Surgery and chemoradiotherapy are both accepted standards for the curative intent treatment of locally advanced mucosal squamous cell carcinoma of the head and neck, but are often prioritized differently depending on the site of tumor origin (e. Read More

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http://dx.doi.org/10.1200/EDBK_201087DOI Listing
May 2018
1 Read

Progress in net cancer survival in Canada over 20 years.

Authors:
Larry F Ellison

Health Rep 2018 Sep;29(9):10-18

Health Statistics Division, Statistics Canada, Ottawa, Ontario.

Background: Monitoring the progress of cancer survival in a population over time is an important part of cancer surveillance.

Data And Methods: Data are from the Canadian Cancer Registry with mortality follow-up through record linkage to the Canadian Vital Statistics Death Database and tax files. Net survival (NS) was derived using the Pohar Perme method. Read More

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September 2018
22 Reads

From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis.

Chemistry 2018 Dec 8;24(68):17915-17920. Epub 2018 Nov 8.

Nikolaev Institute of Inorganic Chemistry SB RAS, 3 acad. Lavrentiev ave., 630090, Novosibirsk, Russia.

Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W I }(DMSO) ](NO ) was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Read More

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http://dx.doi.org/10.1002/chem.201804663DOI Listing
December 2018
19 Reads

Epidemiology of Head and Neck Cancers in Northern Iran: A 10-Year Trend Study From Golestan Province.

Arch Iran Med 2018 Sep 1;21(9):406-411. Epub 2018 Sep 1.

Omid Cancer Research Center, Omid Preventive Medicine and Health Promotion Center, Gorgan, Iran.

Background: Golestan province, in Northern Iran, is a high-risk area for esophageal squamous cell carcinoma (SCC). SCC is also the most common histological type of cancers of the head and neck region including cancers of oral cavity, oropharynx, hypopharynx and larynx. We aimed to present the incidence rate of head and neck SCC (HNSCC) in Golestan province during 2004 and 2013. Read More

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September 2018
4 Reads

[Significance of HPV and cell cycle related proteins in basaloid squamous cell carcinoma of the larynx].

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):682-686

Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

To study the significance of HPV and cell cycle related proteins in basaloid squamous cell carcinoma (BSCC) of the larynx. Twenty-nine cases of laryngeal BSCC from Beijing Tongren Hospital from January 2005 to December 2011 were reviewed. HPV typing by polymerase chain reaction-reverse dot blot (PCR-RDB) and p53, Ki-67, p16, p21 and cyclin D1 expression by immunohistochemistry were performed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.09.006DOI Listing
September 2018
1 Read

Point-of-Care Airway Ultrasonography Prior to an Emergency Cricothyroidotomy: Case Report.

Sultan Qaboos Univ Med J 2018 May 9;18(2):e219-e222. Epub 2018 Sep 9.

Department of Emergency Medicine, Faculty of Medicine, MARA University of Technology, Selangor, Malaysia.

The use of ultrasonography in acute and critical care medicine is becoming increasingly common. However, use of an airway ultrasound as an adjunct to determine the type of intervention needed and assess complications is not common practice. We report a 56-year-old male who presented to the Emergency Department of the Sungai Buloh Hospital, Selangor, Malaysia, in 2015 with hoarseness, stridor and impending respiratory failure. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132533PMC
May 2018
1 Read

One-lung ventilation in a patient with a large mass on the glottis: A case report.

Medicine (Baltimore) 2018 Sep;97(36):e12237

Rationale: One-lung ventilation (OLV) is required during most thoracic surgeries to facilitate surgical visualization by collapsing the lung. Double-lumen tubes and bronchial blockers are two commonly used devices for OLV; however, it may be difficult to place two devices in patients with narrow inlets, such as those that have tumor-induced airway stenosis.

Patient Concerns: We report the case of an adult patient with a lung tumor that was growing rapidly and hemorrhaging; thus, a thoracotomy for lung resection should have been performed as early as possible. Read More

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http://dx.doi.org/10.1097/MD.0000000000012237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133415PMC
September 2018

Synchronous Laryngeal Squamous Cell Carcinoma and Intrahepatic Cholangiocarcinoma Present in an Obese Male with Poor Prognosis.

Anticancer Res 2018 Sep;38(9):5547-5550

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Concurrent laryngeal squamous cell carcinoma and intrahepatic cholangiocarcinoma is rare and no prior report has been found through a PubMed search. Here we report such a case of a 51-year old obese male presenting with hoarseness and trouble swallowing for 2 to 3 months. Imaging findings of computer tomography (CT) and magnetic resonance imaging (MRI) with and without contrast were suspicious for a T3N2 supraglottic laryngeal cancer. Read More

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http://dx.doi.org/10.21873/anticanres.12890DOI Listing
September 2018
13 Reads

Does Reinke's Edema Grade Determine Premalignant Potential?

Ann Otol Rhinol Laryngol 2018 Nov 6;127(11):812-816. Epub 2018 Sep 6.

3 Department of Otolaryngology, Montefiore Medical Center, Bronx, New York, USA.

Objective: Reinke's edema (RE) is a benign disease of the vocal folds with a wide spectrum of clinical severity. We aim to evaluate the clinical impact of RE grade and determine if RE grade correlates with severity of dysplasia and tobacco exposure.

Methods: Patients with isolated RE who underwent surgical excision between December 2010 and December 2014 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1177/0003489418796529DOI Listing
November 2018
13 Reads

Clear cell chondrosarcoma of the larynx.

BMJ Case Rep 2018 Sep 4;2018. Epub 2018 Sep 4.

Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

Chondrosarcomas represent a group of malignant tumours composed of cells producing cartilage, and clear cell chondrosarcomas (CCC) represent a variant of these. A rare case of a laryngeal CCC is presented. The patient was a 70-year-old man who presented with a 6-week history of throat pain, worsening dysphonia and a lump in the neck. Read More

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http://dx.doi.org/10.1136/bcr-2018-226541DOI Listing
September 2018
1 Read

Immediate selective laryngeal reinnervation in vagal paraganglioma patients.

J Laryngol Otol 2018 Sep 5;132(9):846-851. Epub 2018 Sep 5.

Royal National Throat,Nose and Ear Hospital,University College London Hospital NHS Trust,UK.

Objective: This prospective case series aimed to present the outcomes of immediate selective laryngeal reinnervation.

Methods: Two middle-aged women with vagal paraganglioma undergoing an excision operation underwent immediate selective laryngeal reinnervation using the phrenic nerve and ansa cervicalis as the donor nerve. Multidimensional outcome measures were employed pre-operatively, and at 1, 6 and 12 months post-operatively. Read More

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http://dx.doi.org/10.1017/S0022215118000476DOI Listing
September 2018
11 Reads