23,746 results match your criteria Malignant Tumors of the Larynx

Projections of smoking-related cancer mortality in Australia to 2044.

J Epidemiol Community Health 2022 Jun 24. Epub 2022 Jun 24.

The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia.

Background: While many high-income countries including Australia have successfully implemented a range of tobacco control policies, smoking remains the leading preventable cause of cancer death in Australia. We have projected Australian mortality rates for cancer types, which have been shown to have an established relationship with cigarette smoking and estimated numbers of cancer deaths attributable to smoking to 2044.

Methods: Cancer types were grouped according to the proportion of cases currently caused by smoking: 8%-30% and >30%. Read More

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Exosomes from M2 macrophages promoted glycolysis in FaDu cells by inhibiting PDLIM2 expression to stabilize PFKL.

Neoplasma 2022 Jun 20. Epub 2022 Jun 20.

ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.

Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent malignant diseases worldwide. LSCC patients suffer from a severe decline in life quality, due to the essential roles of the larynx in basic functions in a human body. The overarching goal of the present study is to explore whether exosome from M2 macrophages promotes LSCC by targeting glycolysis. Read More

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Comprehensive analysis reveals COPB2 and RYK associated with tumor stages of larynx squamous cell carcinoma.

BMC Cancer 2022 Jun 17;22(1):667. Epub 2022 Jun 17.

Department of Otolaryngology Head and Neck Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, No.3 Qingchun East Road, Hangzhou, 310016, Zhejiang, China.

Background: Laryngeal squamous cell carcinoma (LSCC) is one of the highly aggressive malignancy types of head and neck squamous cell carcinomas; genes involved in the development of LSCC still need exploration.

Methods: We downloaded expression profiles of 96 (85 in advanced stage and 11 in early stage) LSCC patients from TCGA-HNSC. Function enrichment and protein-protein interactions of genes in significant modules were conducted. Read More

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Gastrointestinal Endoscopy Performed by Gastroenterologists: Opportunistic Screening Strategy for Newly Diagnosed Head and Neck Cancers.

Front Oncol 2022 27;12:793318. Epub 2022 May 27.

Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Aim: Approximately 66% of head and neck cancers are diagnosed at an advanced stage. This prospective study aimed to detect newly diagnosed head and neck cancers using regular upper gastrointestinal (UGI) endoscopy with oral-pharynx-larynx examination.

Methods: A total of 2,849 patients underwent UGI endoscopy with an additional oral-pharynx-larynx examination. Read More

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Opium Use and Cancer Risk: A Comprehensive Systematic Review and Meta-Analysis of Observational Studies.

Int J Clin Pract 2022 18;2022:5397449. Epub 2022 Feb 18.

Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran.

Background: Epidemiological studies have reported inconsistent associations between opium use and cancer risk. We therefore conducted a systematic review and meta-analysis to investigate the relationship between opium use and cancer risk.

Methods: We searched PubMed, Scopus, ISI Web of Knowledge, and Google Scholar until February 2021 and references of retrieved relevant articles for observational studies that reported the risk of cancer in relation to opium use. Read More

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Serum Proteomics in Patients with Head and Neck Cancer: Peripheral Blood Immune Response to Treatment.

Int J Mol Sci 2022 Jun 4;23(11). Epub 2022 Jun 4.

Department of Surgical Sciences, Uppsala University, 751 85 Uppsala, Sweden.

In this real-world study, the aims were to prospectively evaluate the expression of inflammatory proteins in serum collected from head and neck cancer patients before and after treatment, and to assess whether there were differences in expression associated with treatment modalities. The mixed study cohort consisted of 180 patients with head and neck cancer. The most common tumor sites were the oropharynx ( = 81), the oral cavity ( = 53), and the larynx ( = 22). Read More

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Prognostic analysis of lymph node ratio of patients with disease recurrence previously submitted to cervical dissection surgery for head and neck cancer.

Rev Col Bras Cir 2022 1;49:e20223178. Epub 2022 Jun 1.

- Pontifícia Universidade Católica de Campinas, Cirurgia de Cabeça e Pescoço - Campinas - SP - Brasil.

Introduction: the variable lymph node ratio has recently been studied as a possible influencer in the survival of patients diagnosed with head and neck cancer.

Objective: to analyze the correlation between lymph node density and survival of recurred disease patients previously submitted to cervical dissection surgery due to head and neck squamous cell carcinoma.

Method: we retrospectively analyzed 71 medical records of patients treated at the Head and Neck Surgery Service of the Pontifícia Universidade Católica de Campinas who had undergone cervical dissection surgery and presented tumor recurrence between 2006 and 2019. Read More

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External Radiotherapy for Locoregional Control in Thyroid Carcinoma.

Methods Mol Biol 2022 ;2534:215-224

Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.

Most patients with well-differentiated thyroid cancers (WDTC) are adequately treated with surgery, radioactive iodine, and TSH suppression by thyroxine. External radiotherapy (ERT) is reserved for selected cases and for older patients. Some of the indications for ERT to neck include adjuvant treatment for gross or microscopic disease after surgery, palliation of locally advanced unresectable tumor, or as salvage for recurrent disease which is not amenable to surgery or does not uptake radioactive iodine. Read More

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How I do it: modified lichtenberger-brown tracheoesophageal puncture procedure.

J Otolaryngol Head Neck Surg 2022 Jun 6;51(1):24. Epub 2022 Jun 6.

Department of Diagnostic Imaging and Radiotherapy, Medical University "Prof. Dr. P. Stoyanov", Varna, Bulgaria.

Background: Tracheoesophageal puncture (TEP) with use of a prosthesis is nowadays a standard for voice restoration after laryngectomy. Different TEP approaches exist.

Methods: We retrospectively reviewed our series of patients who underwent TEP by a novel technique, based partially on the Lichtenberger endo-extralaryngeal needle carrier. Read More

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Infected Thyroglossal Duct Cyst in a Neonate: A Report of a Rare Case.

Am J Case Rep 2022 Jun 6;23:e936659. Epub 2022 Jun 6.

Department of Medical Education, University of Central Florida College of Medicine, Orlando, FL, USA.

BACKGROUND Thyroglossal duct cysts are the most common congenital cervical anomalies, often presenting as midline neck cysts. The mean age of presentation of pediatric thyroglossal duct cysts varies between 5 and 9 years old, with rare cases younger than 1 year old. This case report details a rare case of an infected thyroglossal duct cyst presenting during the neonatal period as an upper airway obstruction. Read More

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Assessment of gene expressions from squamous cell carcinoma of the head and neck to predict radiochemotherapy-related xerostomia and dysphagia.

Acta Oncol 2022 Jul 3;61(7):856-863. Epub 2022 Jun 3.

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany.

Purpose: We tested the hypothesis that gene expressions from biopsies of locally advanced head and neck squamous cell carcinoma (HNSCC) patients can supplement dose-volume parameters to predict dysphagia and xerostomia following primary radiochemotherapy (RCTx).

Material And Methods: A panel of 178 genes previously related to radiochemosensitivity of HNSCC was considered for nanoString analysis based on tumour biopsies of 90 patients with locally advanced HNSCC treated by primary RCTx. Dose-volume parameters were extracted from the parotid, submandibular glands, oral cavity, larynx, buccal mucosa, and lips. Read More

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Deregulation of purinergic ectoenzyme activity in head and neck cancer promotes immunosuppression.

Mol Biol Rep 2022 Jun 1. Epub 2022 Jun 1.

Graduate Program in Biochemistry, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil.

Background: Head and neck cancer (HNC) comprises a spectrum of neoplasms that affect the upper aerodigestive tract and are the sixth most common cancers worldwide. Individuals with HNC exhibit various symptoms and metabolic changes, including immune alterations and alterations of the purinergic pathway, which may signal worse outcomes. Therefore, the purpose of this research was to measure the activity of purinergic ectoenzymes and interleukins in patients with HNC, oral cavity cancer, and larynx cancer. Read More

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Hearing Loss After Cisplatin-based Chemoradiotherapy for Locally Advanced Head and Neck Cancer: A Prospective Single-institution Study.

Anticancer Res 2022 Jun;42(6):3003-3009

Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy;

Background/aim: A single-institution prospective study was conducted to evaluate hearing loss rate after intensity modulated radiotherapy with concomitant cisplatin-based chemotherapy (CRT) for locally advanced head and neck cancer and identify cochlear dosimetric parameters associated with hearing loss risk.

Patients And Methods: Hearing assessment, patients' characteristics, tumor-related variables, and cochlear quantitative dosimetric factors for adults with locally advanced head and neck cancer treated with CRT were prospectively collected. Each patient repeated audiometry at baseline (pre-CRT), 1 month after CRT, and then every 3 to 6 months. Read More

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Nivolumab for recurrent or metastatic head and neck cancer patients with non-squamous cell carcinoma and/or a primary subsite excluded from CheckMate141, a retrospective study.

Oral Oncol 2022 Jul 27;130:105932. Epub 2022 May 27.

Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan. Electronic address:

Objectives: In CheckMate 141, nivolumab significantly improved overall survival (OS) in patients with platinum-refractory recurrent or metastatic squamous cell carcinomas (R/M SCC) of the head and neck. However, reports on nivolumab for patients with non-SCC and/or a primary subsite excluded from CheckMate 141 are limited.

Materials And Methods: We conducted a retrospective analysis of R/M head and neck cancer patients who received nivolumab. Read More

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A Rare Case of Aggressive Metastatic Laryngeal Chondrosarcoma Presenting as Bilateral Necrotizing Pneumonia.

Ear Nose Throat J 2022 May 29:1455613221100005. Epub 2022 May 29.

Hematology Oncology, 22423Saint Michael's Medical Center, Newark, NJ, USA.

Laryngeal chondrosarcomas are rare tumors that account for only 0.2% of malignant tumors of the larynx. Approximately 80% of these tumors are low grade and well differentiated and are associated with a good long-term prognosis. Read More

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Surgeon Volume and Laryngectomy Outcomes.

Laryngoscope 2022 May 30. Epub 2022 May 30.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.

Objective: To examine the relationship between surgeon volume and operative morbidity and mortality for laryngectomy.

Data Sources: The Nationwide Inpatient Sample was used to identify 45,156 patients who underwent laryngectomy procedures for laryngeal or hypopharyngeal cancer between 2001 and 2011. Hospital and surgeon laryngectomy volume were modeled as categorical variables. Read More

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Sex Differences in the Prevalence of Head and Neck Cancers: A 10-Year Follow-Up Study of 10 Million Healthy People.

Cancers (Basel) 2022 May 20;14(10). Epub 2022 May 20.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Background: Descriptive epidemiologists have repeatedly reported that males are more susceptible to head and neck cancers. However, most published data are those of cross-sectional studies, and no population-based cohort study has yet been published. The aim of this study was to compare the prevalence of head and neck cancers in healthy males with females. Read More

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Metabolic Profiling and In Vitro Assessment of the Biological Activities of the Ethyl Acetate Extract of "Endozoic of sp. Marine Sponge" from the Red Sea (Egypt).

Mar Drugs 2022 May 15;20(5). Epub 2022 May 15.

Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.

Marine sponge-derived endozoic fungi have been gaining increasing importance as promising sources of numerous and unique bioactive compounds. This study investigates the phytochemical profile and biological activities of the ethyl acetate extract of derived from sp. sponge. Read More

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Multicentre study on resection margins in carcinoma of the oral cavity, oro-hypopharynx and larynx.

Acta Otorhinolaryngol Ital 2022 Apr;42(2):126-139

Department of Medical Oncology, CRO Aviano, Pordenone, Italy.

Objective: The prognostic significance of the resection margins is still subject of conflicting opinions. The purpose of this paper is to report the results of a study on the margins in carcinoma of the oral cavity, oro-hypopharynx and larynx.

Methods: A multicentre prospective study was carried out between 2015 and 2018 with the participation of 10 Italian reference hospitals. Read More

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Patient Benefit and Quality of Life after Robot-Assisted Head and Neck Surgery.

Timon Hussain

Laryngorhinootologie 2022 May 23;101(S 01):S160-S185. Epub 2022 May 23.

Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Essen, Universität Duisburg-Essen.

Robotic systems for head and neck surgery are at different stages of technical development and clinical application. Currently, robotic systems are predominantly used for transoral surgery of the pharynx and larynx. Robotic surgery of the neck, the thyroid, and the middle and inner ear is much less common; however, some oncological and functional outcomes have been reported. Read More

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Machine-learning-assisted spontaneous Raman spectroscopy classification and feature extraction for the diagnosis of human laryngeal cancer.

Comput Biol Med 2022 Jul 18;146:105617. Epub 2022 May 18.

Division of Electrical and Computer Engineering, College of Engineering, Louisiana State University, Baton Rouge, LA, 70803, USA. Electronic address:

The early detection of laryngeal cancer significantly increases the survival rates, permits more conservative larynx sparing treatments, and reduces healthcare costs. A non-invasive optical form of biopsy for laryngeal carcinoma can increase the early detection rate, allow for more accurate monitoring of its recurrence, and improve intraoperative margin control. In this study, we evaluated a Raman spectroscopy system for the rapid intraoperative detection of human laryngeal carcinoma. Read More

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Granular cell tumor of the vocal cord: Case Report and Literature Review.

Int J Surg Case Rep 2022 Jun 11;95:107193. Epub 2022 May 11.

Department of General Surgery, Clínica Universitaria Reina Fabiola, Universidad Católica de Córdoba, Oncativo 1248. Córdoba Capital, Argentina. Electronic address:

Introduction And Importance: Granular cell tumors (GCT) are rare neoplasms. The most common places are the head and neck. The larynx accounts for 3-10% of cases. Read More

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The implications of gene mutations in salivary DNA for noninvasive diagnosis of head and neck cancer with a focus on oral cancer.

Oral Oncol 2022 Jul 17;130:105924. Epub 2022 May 17.

College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China; Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

DNA-based liquid biopsy as a diagnostic strategy of head and neck squamous cell carcinoma (HNSCC) has emergingly gained momentum. In this letter, we identified 6 studies contained 274 patients with HNSCC focused on gene mutations in salivary DNA. We observe that the incidence of DNA mutations with at least one gene mutated ranges from 63% to 95. Read More

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Implementing a Statistical Parametric Speech Synthesis System for a Patient with Laryngeal Cancer.

Sensors (Basel) 2022 Apr 21;22(9). Epub 2022 Apr 21.

Multimedia Department, Polish-Japanese Academy of Information Technology, 02-008 Warsaw, Poland.

Total laryngectomy, i.e., the surgical removal of the larynx, has a profound influence on a patient's quality of life. Read More

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Factors influencing outcomes in selective neck dissection in 661 patients with head and neck squamous cell carcinoma.

BMC Surg 2022 May 19;22(1):196. Epub 2022 May 19.

Department of Otorhinolaryngology, Head and Neck Surgery, Greifswald University Medicine, University of Greifswald, Fleischmannstraße 8, 17475, Greifswald, Germany.

Background: Selective neck dissection (SND) is the surgical treatment of choice in squamous cell carcinoma of the head and neck (HNSCC) with suspected or manifest metastases in the cervical lymph nodes. For SND to be successful, treated lymph node levels should be selected according to anatomic considerations and the extent of the disease. Aim of this study was to identify neck dissection levels that had an impact on individual prognosis. Read More

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Recurrence pattern with respect to two different dose fractionations in patients with locally advanced head and neck cancer treated with chemoradiation using image-guided volumetric arc therapy.

Head Neck 2022 Jul 10;44(7):1690-1701. Epub 2022 May 10.

HBCH, Sangrur, India.

Background: Patients with head and neck cancer were treated with either 70 Gy in 35 fractions (Arm A) or 66 Gy in 30 fractions (Arm B).

Materials And Methods: Total 168 patients of carcinoma oropharynx, larynx, and hypopharynx treated with radical chemoradiation in two Arm A versus B (65 vs. 103 patients). Read More

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Inflammatory myofibroblastic tumour of the larynx: report of a case.

Ear Nose Throat J 2022 May 9:1455613221101087. Epub 2022 May 9.

Department of Molecular Medicine, 9311Sapienza University of Rome, Italy.

Only 0.3-1% of laryngeal cancer are non-squamous cell neoplasms. Of these, a rare entity is inflammatory myofibroblastic tumour (IMT), in which anaplastic lymphoma kinase-1 (ALK-1) is frequently expressed. Read More

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Health of greenspace workers: Morbidity and mortality data from the AGRICAN cohort.

Environ Res 2022 Sep 6;212(Pt C):113375. Epub 2022 May 6.

ISPED, Université de Bordeaux, 146 rue Léo Saignat, 33076, Bordeaux, France; INSERM U1219 Epicene, 146 rue Léo Saignat, 33076, Bordeaux, France; Service Santé Travail Environnement - CHU de Bordeaux, Place Amélie Raba Léon, 33076, Bordeaux, France.

Introduction: Knowledge on the health of greenspace workers is scarce, even though they are exposed to many occupational hazards. The aim of this study was to analyze mortality by cause, prevalence of some non-cancer diseases, and incidence of the main cancers among greenspace workers.

Methods: A sub-cohort of greenspace workers was formed within the AGRICAN cohort. Read More

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September 2022

Biological roles and clinical significance of estrogen and androgen receptors in head and neck cancers.

J Cancer 2022 4;13(7):2189-2199. Epub 2022 Apr 4.

General Hospital, Clinical Medical Academy, Shenzhen University, Shenzhen 518055, Guangdong, China.

Head and neck cancers (HNC) include malignant tumors that grow in and around the mouth, larynx, throat, sinuses, nose, and salivary glands. Accumulating evidence in malignancies suggests the aberrant expressions of the estrogen receptor (ER) and the androgen receptor (AR) in HNC, such as in laryngeal cancer and cancer of the salivary gland. Moreover, the signaling pathways involving these receptors that mediate tumorigenesis, proliferation, apoptosis, migration, and invasion have been elucidated. Read More

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Metastasis to the Oral Cavity: Report of 12 Cases.

Am J Dermatopathol 2022 May 3. Epub 2022 May 3.

Department of Dermatology, Medical School, Hospital das Clinicas, University of São Paulo, São Paulo, Brazil.

Abstract: Oral cavity is not a common route for metastatic dissemination; metastasis to the oral region may affect soft tissues and jawbones, accounting for approximately 1% of all oral malignant neoplasms. The diagnosis of metastatic lesions to the oral cavity is usually challenging to clinicians and pathologists because of their complexity and rarity. We present a series of 12 metastatic neoplasms to the oral cavity that were detected previously or after the diagnosis of the primary tumor. Read More

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