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Sisli Etfal Hastan Tip Bul 2021 17;55(1):134-137. Epub 2021 Mar 17.

Department of Otorhinolaryngology, University of Health Sciences Turkey, Sisli Hamidiye Etfal Teaching and Research Hospital, Istanbul, Turkey.

We present a case of Giant Cell-Rich Solitary Fibrous Tumor also known as Giant cell angiofibroma, occuring in sublingual region, to our knowledge, which has never been reported before. Forty-nine years old female who presented with painless, slowly growing mass in the sublingual region underwent excisional surgery and was diagnosed with giant cell-rich solitary fibrous tumor previously referred to as giant cell angiofibroma. In our report, we aimed to report the unusual localization of this rare tumor, examine the new nomenclature and classification of giant cell-rich solitary sibrous tumor or giant cell angiofibroma and review the literature regarding head and neck localization of this tumor. Read More

Pan Afr Med J 2021 9;38:146. Epub 2021 Feb 9.

Département d´Odontologie Chirurgicale, Faculté de Médecine Dentaire de Rabat, Université Mohammed V, Rabat, Maroc.

Pleomorphic adenoma is a benign mixed tumor, which is composed of myoepithelial and epithelial cells. A fibrous capsule separates these cells from the surrounding tissues. Pleomorphic adenoma is the most common salivary gland tumour accounting for 40-70% of all major and minor salivary gland tumours. Read More

Br J Oral Maxillofac Surg 2021 05 9;59(4):500-501. Epub 2021 Mar 9.

University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Mindelsohn Way, Birmingham, United Kingdom.

BMC Oral Health 2021 03 11;21(1):114. Epub 2021 Mar 11.

Department of Surgery, Stomatology, Pathology, and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo, 17012-901, Brazil.

Background: The aims of this study were to determine intra (ILVD) and peritumoral (PLVD) lymphatic vessel density (LVD), and to investigate the relationship of LVD with occult metastasis and prognosis.

Methods: Eighty-seven oral squamous cell carcinomas, in clinical stages I or II, arising in the tongue or floor of the mouth were stained with podoplanin. Lymphatic vessels were quantified in intra and peritumoral areas by sequential analysis and hot spot evaluation. Read More

BMC Surg 2021 Mar 8;21(1):120. Epub 2021 Mar 8.

Plastic Surgery Department, Shifa International Hospital, Pitras Bukhari Road H-8, Islamabad, Pakistan.

Background: Most of the head and neck cancers are time-critical and need urgent surgical treatment. Our unit is one of the departments in the region, at the forefront in treating head and neck cancers in Pakistan. We have continued treating these patients in the COVID-19 pandemic with certain modified protocols. Read More

J Clin Exp Dent 2021 Mar 1;13(3):e240-e249. Epub 2021 Mar 1.

PhD, Department of Dentistry, Unichristus, Fortaleza, Ceará, Brazil.

Background: Retrospectively to evaluate the influence of radiochemotherapy (RCT) in the treatment of surgically and non-surgically treated Oral Squamous Cell Carcinoma (OSCC).

Material And Methods: We analysed 934 patients treated in Hospital Haroldo Juaçaba (2000-2014; 15 years of study) by extraction of data type of cancer, localization of tumour, sex, age, race, education level, risk factors (smoking and alcohol use), year of diagnosis, TNM stage, therapeutic approach, health system used (public or private) and overall survival (OS). Surgically and non-surgically treated OSCC were compared by chi-square and Fisher's exact tests, and their prognostic factors were analysed by log-rank Mantel-Cox plus Cox regression tests (SPSS 20. Read More

BMC Cancer 2021 Mar 5;21(1):225. Epub 2021 Mar 5.

Department of General Dentistry, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou, China.

Background: Our goal was to analyze the incidence of level VI metastasis in previously untreated oral squamous cell carcinoma (SCC) patients and their clinicopathological and prognostic characteristics.

Methods: Oral SCC patients with level VI metastasis were retrospectively enrolled, and their demographic and pathologic features as well as their survival data were descriptively analyzed.

Results: A total of 13 cases from 1875 patients were included, all patients had SCC at the floor of mouth (SCCFOM). Read More

BMJ Case Rep 2021 Feb 19;14(2). Epub 2021 Feb 19.

Oral & Maxillofacial Department, St George's University Hospitals NHS Foundation Trust, London, UK.

Schwannomas or neurilemmomas are slow-growing, benign and often firm lumps that are typically painless. They are extremely rare in the oral cavity, with the tongue and the palate being the most common intraoral sites. This is a case report of this pathology in the floor of the mouth. Read More

Hinyokika Kiyo 2021 Jan;67(1):31-35

The Department of Urology, Japan Red Cross Wakayama Medical Center.

A 66-year-old woman underwent concurrent chemoradiotherapy (CCRT) for stage IIA cervical cancer. However, two recurrent masses were detected at the vaginal stump 6 years after CCRT, and we performed laparoscopic total pelvic exenteration to obtain a complete cure. Because the terminal ileum appeared white secondary to the effects of radiotherapy, we constructed an ileal conduit using the ileum, approximately 40 cm toward the mouth from the ileocecum. Read More

BMC Oral Health 2021 01 22;21(1):40. Epub 2021 Jan 22.

Department of Oral and Maxillofacial Surgery, Nagoya Ekisaikai Hospital, 4-66 Syounen-cho Nakagawa-ku, Nagoya, 454-8502, Japan.

Background: The systemic inflammatory response and nutritional status of patients with malignant tumors are related to postoperative results. We examined the usefulness of the prognostic nutritional index (PNI) as a prognostic tool in patients with oral squamous cell carcinoma who underwent radical surgery.

Methods: From 2008 to 2019, 102 patients (73 males, 29 females; age, 65. Read More

Int J Oral Maxillofac Surg 2021 Jan 4. Epub 2021 Jan 4.

Department of Head and Neck Oncology, Gustave Roussy Institute, University Paris-Saclay, Villejuif, France. Electronic address:

At the study hospital, the lip-split mandibulotomy (LSM) has progressively been replaced by a pull-through (PT) approach. This study compared the outcomes of the LSM and PT approaches in a series of 192 patients with T3-T4a oral tongue and floor of the mouth squamous cell carcinoma treated over the two last decades. No difference in margin status (P = 0. Read More

Mymensingh Med J 2021 Jan;30(1):101-105

Dr Syed Farhan Ali Razib, Associate Professor, Head and Neck Division, Department of ORLHNS, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh; E-mail:

Free flap reconstruction after surgical ablation of head & neck cancer greatly improve the surgical outcome. Microvascular anastomosis is an important part of Microsurgery and it is not widely practiced in every center. A retrospective review was conducted in the Head & Neck Division of Otolaryngology-Head & Neck Surgery Department, Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh from May 2016 to June 2017. Read More

Ann Diagn Pathol 2021 Feb 24;50:151650. Epub 2020 Oct 24.

Department of Pathology, National University Hospital, Singapore, 5 Lower Kent Ridge Road, Main Building Level 3, S(119074). Electronic address:

We present two patients (29 and 67 years) with histomorphologic and immunohistochemical evidence of early high-grade transformation of adenoid cystic carcinoma in the nasal cavity and floor of mouth, respectively. The component of early high-grade transformation was characterized by 1) selective expansion of the luminal (CK7+, c-kit+, p63-) cell component with severe cytologic atypia and significantly increased Ki-67 proliferation index, and 2) retained albeit attenuated abluminal (CK7-, c-kit-, p63+) cells, surrounding nests of high-grade luminal cells. Read More

Oral Oncol 2021 01 19;112:105110. Epub 2020 Nov 19.

Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology (ISMIB), University of Liverpool, Roy Castle Building, 200 London Road, Liverpool L3 9TA, UK.

Objectives: Oral Epithelial Dysplasia (OED) is associated with an increased risk of oral cancer development. The SARS-CoV-2 pandemic is necessitating the suspension or dramatic reduction of face-to-face non-urgent elective services, including OED clinics. Little is known regarding the potential impact of elective services suspension upon the risk of OED progression, and whether alternative strategies (e. Read More

Radiother Oncol 2021 04 18;157:63-69. Epub 2020 Nov 18.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States.

Purpose: To introduce a contouring guideline for the taste bud bearing tongue mucosa for head and neck cancer patients receiving radiotherapy.

Methods And Materials: CT simulation images of oropharyngeal cancer patients were used to delineate both the whole tongue (extrinsic/intrinsic tongue muscles, floor of mouth) and the taste bud bearing tongue mucosa (method A: adaptation of the whole tongue structure; method B: axial adaptation of a mid-sagittal contour). Volumetric and dosimetric parameters of the whole tongue and the two methods of mucosal delineation, spatial overlap between methods A and B, and inter-observer variability for method B were calculated. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Feb 16;131(2):217-220. Epub 2020 Oct 16.

Oral and Maxillofacial Surgery Department Director, Nassau University Medical Center, East Meadow, NY, USA.

Mucoepidermoid carcinoma is the most common salivary gland malignancy, accounting for 27% of all salivary gland cancers. Identified in 1921 and first analyzed in 1945, mucoepidermoid carcinoma has demonstrated a widely diverse histology with several morphologic variants having been described. One rare feature is the formation of intratumoral bone, which has been previously reported once in the English language literature. Read More

J Oral Maxillofac Surg 2021 04 16;79(4):822-829. Epub 2020 Oct 16.

Chalmers J. Lyons Endowed Professor, Chair and Section Head Oral and Maxillofacial Surgery, School of Dentistry and Department of Surgery, University of Michigan, Ann Arbor, MI.

Purpose: Depth of invasion (DOI) is an independent predictor of regional metastasis in oral squamous cell carcinoma. Measurement criteria for DOI were modified in the American Joint Committee on Cancer (AJCC) eighth edition. The purpose of this study was to compare DOI AJCC seventh (DOI7) and eighth (DOI8) edition criteria on frozen section accuracy for decisions regarding elective neck dissection (END) in cT1N0 oral squamous cell carcinoma. Read More

Br J Oral Maxillofac Surg 2021 01 4;59(1):5-15. Epub 2020 Oct 4.

Dept of Maxillofacial Surgery, Queen Elizabeth University Hospital, 1345 Govan Rd, Glasgow, G51 4TF. Electronic address:

Complete tumour resection (R0 margin) is an axiom of surgical oncology. Oral cancer ablation is challenging, due to anatomical, functional, and aesthetic considerations. R0 margin is strongly linked to better survival outcomes with great variation in the R0 % across units. Read More

Medicina (Kaunas) 2020 10 13;56(10). Epub 2020 Oct 13.

Faculty of Medicine and Dentistry, Health Research, Institute of Santiago de Compostela (Instituto de Investigación Sanitaria de Santiago, IDIS), Oral Medicine, Oral Surgery and Implantology University, Santiago de Compostela University, 15782 Santiago de Compostela, Spain.

Head and Neck Squamous Cell Carcinoma (HNSCC) includes cancers from the oral cavity, larynx, and oropharynx and is the sixth-most common cancer worldwide. MicroRNAs are small non-coding RNAs for which altered expression has been demonstrated in pathological processes, such as cancer. The objective of our study was to evaluate the different expression profile in HNSCC subtypes and the prognostic value that one or several miRNAs may have. Read More

Shanghai Kou Qiang Yi Xue 2020 Jun;29(3):275-280

Department of Ultrasound， Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China.

Purpose: To explore the sonographic appearance of leukoplakia in non-masticatory oral mucosa, classifying mucosal leukoplakia according to the characteristics of sonogram, and providing reference for clinical diagnosis and treatment.

Methods: Eighteen patients (24 lesions) were diagnosed as oral leukoplakia at the Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital. The lesions were located in the tongue, floor of mouth, buccal mucosa and libial mucosa. Read More

PLoS One 2020 15;15(9):e0238420. Epub 2020 Sep 15.

General Department, Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, Guangdong, China.

Background: Patients diagnosed with Oral Floor Squamous Cell Carcinoma (OFSCC) face considerable challenges in physiology and psychology. This study explored prognostic signatures to predict prognosis in OFSCC through a detailed transcriptomic analysis.

Method: We built an interactive competing endogenous RNA (ceRNA) network that included lncRNAs, miRNAs and mRNAs. Read More

Case Rep Pathol 2020 25;2020:8882871. Epub 2020 Aug 25.

Department of Surgery, Stomatology, Pathology and Radiology (Area of Pathology), Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.

A 77-year-old woman with a rare oral intraductal papilloma arising from the minor salivary gland located on the floor of the mouth and causing the mucus retention is reported. Microscopically, the lesion was characterized by unicystic cavity exhibiting the lumen partially filled by papillary projections of the ductal epithelium with varying degree of oncocytic metaplasia. Based on the histopathological analysis, the differential diagnosis of oral intraductal papillomas and other ductal neoplasms of salivary origin are discussed. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Jun;34(6):508-511

Department of Ophthalmology and Otorhinolaryngology，Lhasa People's Hospital.

To investigate the feasibility of semi-free transverse cervical artery flaps for repairing the defect of head and neck tumors after operation. Clinical records of 15 patients were retrospectively reviewed. Ten cases were diagnosed as oral cancer, 4 cases as hypopharyngeal carcinoma and 1 case as orbito-facial mucinous adenocarcinoma. Read More

Head Neck 2020 12 22;42(12):3647-3654. Epub 2020 Aug 22.

Department of Oromaxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, Liaoning Province Key Laboratory of Oral Disease, China Medical University, Shenyang, Liaoning Province, China.

Background: We evaluated the clinical applications of the reconstruction of postoperative defects of the oral cavity using contralateral submental artery flaps.

Methods: A retrospective study of 18 patients with postoperative intraoral cancer defects reconstructed with contralateral submental artery perforator flaps between October 2018 and October 2019 in our department was conducted. The defect area, flap size, and complications were evaluated. Read More

Epidemiol Mikrobiol Imunol 2020 ;69(2):64-72

Introduction: Human papillomavirus (HPV) infection plays an important role in the etiopathogenesis of oropharyngeal squamous cell carcinomas. HPV detection in these tumours is a positive prognostic marker. The p16 protein expression, which is detected immunohistochemically, is an indirect marker of active HPV infection. Read More

Int J Pediatr Otorhinolaryngol 2020 Nov 4;138:110265. Epub 2020 Aug 4.

Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, CO, USA; Pediatric Otolaryngology, Children's Hospital Colorado, Aurora, CO, USA. Electronic address:

Introduction: Pediatric cystic sublingual masses often present a diagnostic dilemma for practitioners. Though uncommon, dermoid or epidermoid cysts can present in the sublingual space at any age and are often misdiagnosed as an inflammatory pseudocyst (ranula) or lymphatic malformation. Imaging may not always identify the underlying etiology, requiring physicians to maintain a high index of suspicion for these relatively rare oral cysts. Read More

Medicine (Baltimore) 2020 Aug;99(32):e21521

Department of Anesthesia, Shaoxing University Affiliated First Hospital.

Rationale: The establishment of lung isolation is often particularly challenging for the anesthesiologist in patients with difficult airway. Usually, orotracheal intubation with double lumen tube is the commonly used technique for achieving 1 lung anesthesia. Whereas, in patients with limited mouth opening and restricted cervical mobility, this technique becomes extremely difficult and hazardous. Read More

J Oral Maxillofac Surg 2020 Dec 4;78(12):2306-2315. Epub 2020 Jul 4.

Chalmers J. Lyons Professor, Department Chair and Section Head, Oral and Maxillofacial Surgery, School of Dentistry, Department of Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI. Electronic address:

Purpose: Elective neck dissection (END) versus observation remains controversial for cT1N0M0 oral cavity squamous cell carcinoma (OSCC). The aim of this study was to determine whether neck dissection is indicated for cT1N0M0 OSCC versus observation when considering oral cavity subsites and depth of invasion (DOI) as predictors.

Patients And Methods: A multicenter, ambispective cohort study of patients with cT1N0M0 OSCC treated at the University of Michigan and Beijing Stomatological Hospital from August 1998 to July 2017 with a follow-up end date of July 2019 was performed. Read More

Ann Otol Rhinol Laryngol 2021 Feb 24;130(2):219-222. Epub 2020 Jul 24.

Department of Otolaryngology - Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Objective: Extensive mandibulofacial defects can be challenging to reconstruct. We present the case of a complex mandibulofacial defect reconstructed with a mega, chimeric fibula free flap.

Methods: Ablation of the oral cavity tumor resulted in a large defect involving mandible, floor of mouth, and tongue. Read More