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Braz J Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

Hospital Regional do Vale do Paraíba (HRVP), Taubaté, SP, Brazil.

Introduction: Cancer of the oral cavity and oropharynx exhibits an aggressive behavior and its diagnosis is, in most cases, attained at advanced stages. Total glossectomy is a therapeutic option in locally advanced cancer, and the only choice in the presence of recurrent or residual disease after chemoradiotherapy.

Objective: To evaluate the clinical-epidemiological profile, postoperative complications, survival rates and functional aspects of patients with oral cavity and oropharynx cancer after total glossectomy. Read More

Anticancer Res 2019 Apr;39(4):1907-1914

Department of Internal Medicine, Division of Oncology-Hematology, VA Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, U.S.A.

Background/aim: HPV-mediated oropharyngeal squamous cell carcinoma is associated with an increased survival. The prognostic value of HPV status for other primary sites is unclear. We aimed to assess the effect of HPV status on overall survival in patients with non-oropharyngeal head and neck squamous cell carcinoma (non-OPSCC) using the National Cancer Database (NCDB). Read More

Eur Radiol 2019 Jan 16. Epub 2019 Jan 16.

Institute for Diagnostic and Interventional Radiology, University Hospital Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

Objectives: This study compares reduction of strong metal artifacts from large dental implants/bridges using spectral detector CT-derived virtual monoenergetic images (VMI), metal artifact reduction algorithms/reconstructions (MAR), and a combination of both methods (VMI) to conventional CT images (CI).

Methods: Forty-one spectral detector CT (SDCT) datasets of patients that obtained additional MAR reconstructions due to strongest artifacts from large oral implants were included. CI, VMI, MAR, and VMI ranging from 70 to 200 keV (10 keV increment) were reconstructed. Read More

J Cancer Res Ther 2018 Oct-Dec;14(6):1418-1421

Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Hyderabad, Telangana, India.

Malignant tumors of the salivary gland are rare, clinically diverse group of neoplasms, among which mucoepidermoid carcinomas (MECs) are reported to be most frequently occurring epithelial carcinomas. MEC at times misleads the clinician because of its atypical location and innocent appearance. Here, we report a case of low-grade MEC in a 70-year-old female patient in the floor of the mouth mimicking as ranula clinically. Read More

Case Rep Oncol 2018 Sep-Dec;11(3):682-687. Epub 2018 Oct 31.

Department of Pathology, LSU Health Shreveport, Shreveport, Louisiana, USA.

Mucoepidermoid carcinoma (MEC) is the most common malignant epithelial neoplasm of the salivary glands. MECs of the mouth floor are rare, with only a few cases reported. Here we report a MEC of the mouth floor in a 55-year-old woman. Read More

Dentomaxillofac Radiol 2019 Mar 30;48(3):20180240. Epub 2018 Nov 30.

1 Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.

Methods:: A total of 82 patients were included in this study. The apparent diffusion coefficient (ADC) values and time-signal intensity curves (TICs) were measured. Clinical characteristics, ADC value, and TIC pattern were compared between benign and malignant FOM lesions. Read More

Int J Oral Maxillofac Surg 2018 Dec 29;47(12):1507-1510. Epub 2018 Jun 29.

Department of Head and Neck Oncology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Traditional neck dissection for oral squamous cell carcinoma (OSCC) involves removal of the submandibular salivary gland. Several studies have cited the low incidence of direct gland invasion by tumours and have recommended gland-sparing neck dissection. In this study, a detailed audit of level Ib involvement in OSCC was performed in order to assess the feasibility of submandibular gland-sparing in neck dissection; the rate of direct involvement by the primary tumours, the involvement of periglandular level Ib nodes, and their determinants were investigated. Read More

BMJ Open 2018 Oct 18;8(10):e019505. Epub 2018 Oct 18.

Faculty of Pharmaceutical Sciences, State University of Campinas, Sao Paulo, Brazil.

Introduction: Oral mucositis is an iatrogenic condition of erythematous inflammatory changes which tends to occur on buccal and labial surfaces, the ventral surface of the tongue, the floor of the mouth and the soft palate of patients receiving chemotherapy. This protocol of ongoing randomised parallel group clinical trial aims to access the therapeutic effect of an herbal gel containing 2.5% Verlot standardised extract on oral mucositis in patients with head and neck cancer compared with low-level laser therapy. Read More

World J Surg Oncol 2018 Oct 10;16(1):201. Epub 2018 Oct 10.

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Background: Glomus tumors are rare benign neoplasms that usually occur in the upper and lower extremities. Oral cavity involvement is exceptionally rare, with only a few cases reported to date.

Case Presentation: A 24-year-old woman with complaints of swelling in the left floor of her mouth for 6 months was referred to our institution. Read More

Ear Nose Throat J 2018 Sep;97(9):314-322

Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen East, Denmark.

We conducted a retrospective follow-up study to determine if adjunctive radiotherapy (RT) affected disease-free survival in patients with oral squamous cell carcinoma (SCC) who were found to have close surgical margins after tumor resection. Our study population was made up of 110 patients-72 men and 38 women, aged 30 to 94 years (median: 66) at the time of diagnosis. Their follow-up ranged from 12 days to 5. Read More

Bull Tokyo Dent Coll 2018 ;59(3):207-212

Department of Oral and Maxillofacial Radiology, Tokyo Dental College.

On images, a dermoid cyst is often described as resembling a "sack of marbles" or "marbles in a bag". Typically, it comprises an inhomogeneity filled with multiple nodules in a fluid matrix on both computed tomography and magnetic resonance imaging (MRI). How it appears, however, will vary depending on its histological contents, which may cause confusion in arriving at a diagnosis. Read More

Surg Oncol 2018 Sep 29;27(3):490-494. Epub 2018 May 29.

Department of Otorhinolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.

Objective: Surgery for locally advanced oral cancer often requires wide resections of multiple subsites of the oral cavity, including the oral tongue, floor of the mouth, and lower gingiva, and it causes chewing and swallowing disorders. The aim of this prospective, observational study was to determine which subsites have a greater impact on chewing and swallowing disorders after surgery.

Methods: A prospective, observational study was conducted involving 52 patients who underwent surgery for locally advanced oral cancer with free flap reconstruction. Read More

J Craniomaxillofac Surg 2018 Sep 1;46(9):1586-1592. Epub 2018 Jun 1.

Department of Oral and Maxillofacial Surgery, (Head: Prof. Dr. Dr. Jörg Wiltfang), University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3, 24105 Kiel, Germany.

Purpose: The aim of this study was to investigate the oncolytic properties of KI-21-3, a shortened fragment of LL-37, against oral squamous cell carcinoma (OSCC) in an animal model.

Materials And Methods: Twelve athymic nude mice were divided into a therapy and a control group of six animals each. In both groups, SCC-4 cells were administered extraorally into the floor of the mouth in order to create an OSCC model. Read More

Int J Pediatr Otorhinolaryngol 2018 Oct 2;113:260-265. Epub 2018 Aug 2.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Oral and Maxillofacial Surgery, Augustenburger Platz 1, 13353, Berlin, Germany. Electronic address:

Background: Congenital cysts and fistulas of the neck are common in children, often located in the head and neck area. Belonging to the group of tumor-like conditions, dermoid and epidermoid cysts are dysontogenetic lesions with seldom multiple co-occurrences in infants.

Case Report: We report on a nine-month-old female with a persisting congenital fistula of the tongue. Read More

Med Oral Patol Oral Cir Bucal 2018 Sep 1;23(5):e518-e523. Epub 2018 Sep 1.

Instituto do Câncer do Estado de São Paulo [ICESP], Faculdade de Medicina da Universidade de São Paulo, Dental Oncology Service, São Paulo, Brazil, Avenida Doutor Arnaldo, 251, São Paulo - SP, Brasil, CEP: 01246-000,

Background: Acute toxicity is usually defined as adverse changes occurring immediately or a short time after the start of oncological treatment.

Material And Methods: Cross-sectional retrospective study performed with head and neck cancer patients who underwent radiotherapy from 2013 to 2016.

Results: Ten (1. Read More

Int J Cancer 2018 11 21;143(10):2551-2560. Epub 2018 Sep 21.

Department of Oral and Maxillofacial Surgery, Dokkyo Medical University School of Medicine, Tochigi, Japan.

More than 90% of oral cancers are histopathologically squamous cell carcinomas (SCCs). According to clinical behavior and histopathological features, we hypothesize that oral SCC can originate from either oral squamous epithelium or minor salivary glands. Here, we examined whether some oral SCCs originate from minor salivary glands, and investigated whether these tumors show particularly aggressive biological behavior. Read More

Am J Otolaryngol 2018 Sep - Oct;39(5):497-500. Epub 2018 May 26.

Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA 02114, United States; Division of Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, 02114, United States. Electronic address:

Objective: A plunging ranula is a pseudocystic collection of mucin extravasated from the sublingual gland into the floor of mouth and through the mylohyoid muscle into the neck. While the lining of a ranula is non-secreting and resection of the sublingual gland is adequate for simple sublingual mucoceles, many surgeons attempt to address plunging ranulas with extensive transoral and transcervical dissections. We review our experience managing plunging ranulas with intraoral sublingual gland excision and ranula drainage alone. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2018 Jul;53(7):480-483

Department of Pathology, Hospital of Stomatology, Jilin University, Changchun 130021, China.

To investigate the incidence of malignant tumors in oral and maxillofacial region and the pathological features of various tumors, a total of 3 382 cases of malignant tumors in oral and maxillofacial region admitted to Jilin University from Januarary 2000 to December 2017. The characteristics of age, sex, location and pathological types of all kinds of tumors were analyzed. The median onset age is 57 years old, 51 to 70 years old is a high-risk age group, the ratio of male to female was 1. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2018 Jan;53(1):3-7

Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

To summarize the clinical anatomical features and surgical technique of the submental artery perforator flap (SMAPF), and to evaluate the outcome and value of the flap for oral cavity reconstruction after cancer ablation. A total of 56 patients with oral cancer were included in this study. The modified SMAPF excluded the anterior belly of the digastric muscle and submental fatty tissue. Read More

Pathol Res Pract 2018 Aug 20;214(8):1185-1191. Epub 2018 Jun 20.

Department of Biological Sciences, Bauru School of Dentistry - University of Sao Paulo, Alameda Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, SP, 17.012-901, Brazil. Electronic address:

The biological process of epithelial-to-mesenchymal transition (EMT) has been studied in oral squamous cell carcinoma (OSCC) metastasis, but it is rarely evaluated at several stages of oral carcinogenesis. This study aimed to analyze the presence of SNAIL and E-cadherin proteins, markers of EMT, in the development and progression of OSCC, evaluating excised specimens of potentially malignant lesions (oral leukoplakia with and without dysplasia-OL and OLD, respectively), tumor tissues (OSCC), metastatic lymph nodes (LN), and normal oral mucosa (NOM) by immunohistochemistry, considering subcellular localization. Additionally, SNAIL and E-cadherin transcripts were evaluated in vitro by qPCR, using SCC-9 cell line in comparison to human keratinocytes (HPEC). Read More

J Craniofac Surg 2018 Sep;29(6):e607-e608

Department of Otorhinolaryngology, Near East University, Faculty of Medicine, Nicosia, Cyprus.

Epidermoid cysts are benign lesions, which are usually detected on the floor of the mouth in the head and neck region. They can develop from abnormal epithelial components of an ectoderm tissue during the embryological life or alternatively they can arise from the implanted epithelium after trauma or surgery. The diagnosis of an epidermoid cyst in the maxillary sinus can be challenging and it could be easily mistaken for any benign or malign lesion of the nasal cavity and paranasal sinuses. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 06;31(6):702-708

Department of Oral and Maxillofacial Surgery, Southwest Medical University Affiliated Stomatological Hospital, Luzhou Sichuan, 646000,

Objective: To investigate the efficacy of anterolateral thigh (myocutaneous) flap designed with computed tomography angiography (CTA) to reconstruct oral and maxillofacial soft tissue defects.

Methods: Between January 2011 and December 2015, 23 cases of oral and maxillofacial tumors were treated. There were 14 males and 9 females with the age range from 45 to 72 years (mean, 56. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 06;31(6):696-701

Department of Oncology Plastic Surgery, Hunan Province Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha Hunan, 410008, P.R.China.

Objective: To investigate the clinical anatomy and application of free profunda femoral artery pedicled chimeric myocutaneous perforator flap in the defect reconstruction after radical resection of tongue carcinoma.

Methods: Between April 2011 and January 2016, 44 cases of tongue carcinoma underwent radical resection, and tongue defects were reconstructed by free profunda femoral artery pedicled chimeric myocutaneous perforator flaps at the same stage. There were 40 males and 4 females, with a mean age of 46. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 04;31(4):461-464

Departmentof Oral and Maxillofacial Surgery, the Affiliated Hospital of Guilin Medical College, Guilin Guangxi, 541001, P.R.China.

Objective: To explore the effect of facial artery musculo-mucosal (FAMM) flap to reconstruct tongue and floor of mouth defects.

Methods: Between January 2011 and January 2016, 24 cases of tongue and floor of mouth defects were repaired with FAMM flap after tumor resection. There were 16 males and 8 females, aged from 38 to 70 years with an average of 55 years. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Nov;31(22):1705-1710

Department of Otorhinolaryngology Head and Neck Surgery, Peking University First Hospital, Beijing, 100034, China.

To evaluate the feasibility and effectiveness of coblation assisted transoral surgery for the treatment of oral and oropharyngeal malignancy. 19 patients who suffered from oral or oropharyngeal malignant tumors underwent coblation assisted transoral surgery from August 2008 to August 2017 were studied. According to the tumor sites and pathological results, there were four oral squamous cell carcinoma (SCC) (two tongue carcinoma and two mouth floor carcinoma), eleven oropharygneal SCC (five tonsillar carcinoma, four soft palate carcinoma, one tongue base cartinama and one multiple carcinoma invading both soft palatine and hypopharynx), and four lymphatic and hematopoietic malignancies (three tonsillar tumors and one tumor invading both tonsil and tongue base). Read More

Am J Otolaryngol 2018 Sep - Oct;39(5):646-648. Epub 2018 May 16.

THANC (Thyroid, Head and Neck Cancer) Foundation, 10 Union Square East, Suite 5B, New York, NY 10003, USA; Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel Medical Center, 10 Union Square East, Suite 5B, New York, NY 10003, USA.

Background: Septic arthritis of the sternoclavicular joint is a rare infection associated with significant morbidity and mortality. Several risk factors for septic arthritis have been reported in the literature ranging from immunodeficiency to intravenous drug use.

Case Presentation: A 63-year-old male previously treated for synchronous squamous cell carcinomas of the epiglottis and floor of mouth presented with tenderness and swelling of the sternoclavicular joint two months after tracheostomy decannulation. Read More

J Oral Maxillofac Pathol 2018 Jan-Apr;22(1):108-111

Department of Oral Pathology and Microbiology, Subharti Dental College, Meerut, Uttar Pradesh, India.

Basaloid squamous cell carcinoma is a rare distinct histologic variant of squamous cell carcinoma of the head and neck region. Majority of them can be differentiated from squamous cell carcinoma by their aggressive clinical course and their histological features: the usual site of occurrence of basaloid squamous cell carcinoma is the upper areodigestive tract, floor of mouth and base of tongue. We hereby present two cases of a rare but aggressive basaloid squamous cell carcinoma, both affecting mandible. Read More

J Laryngol Otol 2018 May 3;132(5):446-451. Epub 2018 May 3.

Department of ENT,Faculty of Medicine,Dokuz Eylul University,Izmir,Turkey.

Objective: This study investigated the incidence and routes of submandibular gland involvement in oral cavity carcinoma to determine the feasibility of submandibular gland sparing neck dissection.

Methods: The records of 155 patients diagnosed with oral cavity squamous cell carcinoma, with a total of 183 neck specimens, including those involving level I, were reviewed retrospectively.

Results: Submandibular gland involvement, via direct invasion from the anatomical proximity of T4a tumours, was evident in two patients. Read More

Microsurgery 2018 Oct 2;38(7):795-798. Epub 2018 May 2.

Department of Plastic, Reconstructive and Maxillo-Facial Surgery, and Burn Unity, Centro Hospitalar de São João, Porto Medical School, Porto, Portugal.

Facial artery perforator flaps have been recently reported by different authors for perioral, nasal alar and cheek defects, but not for intraoral reconstruction. We have extended the use of the facial artery perforator flap in a 56-year-old man with a squamous cell carcinoma of left mouth floor, who was submitted to tumor resection with marginal mandibulectomy and left supraomohyoid neck dissection. The flap was designed according to the size of the defect (5 × 3 cm), centered on the perforator to create a symmetric flap and was tunnelled intraorally by means of a 90° rotation. Read More

J Craniomaxillofac Surg 2018 Jun 5;46(6):1001-1006. Epub 2018 Apr 5.

Department of Pathology University Medical Center Utrecht, Heidelberglaan 100, H4.4129, PO Box 85500, NL 3508 GA, Utrecht, The Netherlands.

Introduction: In oral squamous cell carcinoma (OSCC) the differentiation grade of the tumor is determined on the biopsy and the resection specimen. The relation between tumor grade, nodal metastasis and survival is debatable. The aims of this study were to determine the correlation between differentiation grade of the biopsy and the resection specimen. Read More

Oral Oncol 2018 May 16;80:16-22. Epub 2018 Mar 16.

Department of Radiation and Cellular Oncology, University of Chicago, 5758 S. Maryland Avenue, M/C 9006, Chicago, IL 60637, USA. Electronic address:

Objectives: Definitive chemoradiation (CRT) for oral cavity squamous cell carcinoma (OC-SCC) is often criticized for poor efficacy or toxicity. We describe a favorable 20-year experience of primary CRT for locally-advanced OC-SCC.

Materials And Methods: Patients with locally-advanced, stage III/IV OC-SCC receiving primary concomitant CRT on protocols from 1994 to 2014 were analyzed. Read More

Magn Reson Imaging 2018 09 26;51:69-78. Epub 2018 Apr 26.

Siemens Healthcare K.K., Tokyo, Japan.

Purpose: In this study, we aimed to determine the usefulness of diffusion kurtosis imaging (DKI) as a noninvasive method for evaluation of the histologic grade and lymph node metastasis in patients with oral carcinoma.

Materials And Methods: Twenty-seven patients with oral carcinoma were examined with a 3-T MR system and 16-channel coil. DKI data were obtained by a single-shot echo-planar imaging sequence with repetition time, 10,000 ms; echo time, 94 ms; field of view, 250 × 204. Read More

J Otolaryngol Head Neck Surg 2018 Apr 24;47(1):27. Epub 2018 Apr 24.

Division of Otolaryngology-Head and Neck Surgery, University of Alberta, 1E4 Walter Mackenzie Center, 8440 112 Street, Edmonton, AB, T6G 2B7, Canada.

Background: Defects following resection of tumors in the head and neck region are complex; more detailed and defect-specific reconstruction would likely result in better functional and cosmetic outcomes. The objectives of our study were: 1) to improve the understanding of the two- and three-dimensional nature of oral cavity and oropharyngeal defects following oncological resection and 2) to assess the geometric dimensions and the shapes of fasciocutaneous free flaps and locoregional tissue flaps required for reconstruction of these defects.

Methods: This study was an anatomic cadaveric study which involved creating defects in the oral cavity and oropharynx in two cadaveric specimens. Read More

J Oral Pathol Med 2018 Jul 29;47(6):557-565. Epub 2018 Apr 29.

Newcastle University Medicine Malaysia, Iskandar Puteri, Malaysia.

Background: Clinically identifiable potentially malignant disorders (PMD) precede oral squamous cell carcinoma development. Oral lichenoid lesions (OLL) and proliferative verrucous leukoplakia (PVL) are specific precursor lesions believed to exhibit both treatment resistance and a high risk of malignant transformation (MT).

Methods: A retrospective review of 590 PMD patients treated in Northern England by CO laser surgery between 1996 and 2014 was carried out. Read More

Surg Radiol Anat 2018 Aug 9;40(8):891-897. Epub 2018 Apr 9.

Human Anatomy Unit, Department of Surgery and Cancer, Imperial College London, Charing Cross Campus, St Dunstan's Road, London, W6 8RP, UK.

Purpose: Gold standard recipient arteries in head and neck free flap microvascular reconstruction are currently branches of the external carotid. However, these arteries can be compromised by neck dissection or radiotherapy, resulting in 'vessel-depleted neck' and 'frozen neck' respectively. In such cases, the transverse cervical artery (TCA) may be a suitable recipient artery. Read More

Ann Ital Chir 2018 ;89:62-65

Aim: The success rates of free flaps in patients undergoing head and neck cancer (HNC) surgery are very high (95%- 97%) but the development of a surgical site infection (SSI) can put flap viability at risk. The aim of our study is to identify the risk factors for SSI in patients undergo free flaps reconstruction after head and neck cancer removal.

Material Of Study: Seventyseven patients (44 male and 33 female) from April 2006 to April 2015 admitted at the Department of Maxillofacial Surgery of the University of Naples "Federico II" were included in this study. Read More

Clin Oral Investig 2018 May 23;22(4):1625-1630. Epub 2018 Mar 23.

Department of Oral and Maxillofacial Surgery, University of Erlangen-Nürnberg, Glückstrasse 11, 91054, Erlangen, Germany.

Objectives: This study aimed to identify anatomical areas where resections of oral squamous cell carcinomas (OSCC) are significantly associated with close or positive margins.

Materials And Methods: This retrospective study included 330 patients with a primary OSCC from 2010 to 2015. Patient and tumour data were categorised into three groups by R-status (R0 [clear], ≥ 5 mm, 185 patients [56. Read More

J Craniofac Surg 2018 Jul;29(5):1300-1304

State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.

Flaps-based microsurgery is routinely applied to reconstruct oral floor defects caused by oncologic resection. To prevent orocutaneous fistulae, flaps are frequently sutured with buccal vestibule mucosa after sacrificing the alveolar process. The patients suffered denture loss and irreversible structural damage. Read More

Microcirculation 2018 05 16;25(4):e12448. Epub 2018 Apr 16.

Cátedra de Farmacología Aplicada, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina.

Objective: To assess sublingual microcirculation in cirrhotic patients and its relationship to spider angiomas, complications, and outcome.

Methods: Thirty-one cirrhotic patients were prospectively compared to 31 matched controls. Sublingual microcirculation was evaluated by videomicroscopy. Read More

Int J Clin Oncol 2018 Aug 28;23(4):625-633. Epub 2018 Feb 28.

Research Department-Children's Cancer Hospital Egypt (CCHE-57357), 1 Seket Al-Emam Street, El-Madbah El-Kadeem Yard, El-Saida Zeinab, Cairo, Egypt.

Background: Thyroid carcinoma is a very rare tumor in the pediatric age group, accounting for only 1.5-3% of childhood carcinomas in the United States and Europe. We aimed to identify the risk of a second malignancy among pediatric thyroid cancer survivors. Read More

Dent Clin North Am 2018 04;62(2):177-193

UNC School of Dentistry, The University of North Carolina at Chapel Hill, Koury Oral Health Sciences Building, Room 4508, Chapel Hill, North Carolina 27599-7450.

Despite improvements in the oral health status of the US population as a whole, a disproportionately higher burden of oral diseases and disorders are borne by those individuals from low-income and racial and ethnic minority groups. These differences in health status, health outcomes, or health care use between distinct socially disadvantaged and advantaged groups are well documented and known as health disparities. It is vital that members of the dental profession understand the distribution of oral health and disease across different populations and the life span and participate in developing innovative and sustainable approaches to eliminate oral health disparities. Read More

BMJ Case Rep 2018 Feb 22;2018. Epub 2018 Feb 22.

Department of Translational Physiology, AMC, Amsterdam, North Holland, The Netherlands.

Epidemiol Serv Saude 2018 15;27(1):e20171416. Epub 2018 Feb 15.

Faculdade de Odontologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil.

Objective: to analyze the trends in the concession of social security sick pay for oral and oropharyngeal cancer, from 2006 to 2013, in Brazil.

Methods: time series study using data of workers insured by the Brazilian National Institute of Social Security (INSS); Prais-Winsten generalized linear regressions were used to calculate the annual percentage change (APC).

Results: social security benefits for oral and oropharyngeal cancer presented significant increase (APC=9. Read More

J Otolaryngol Head Neck Surg 2018 Feb 13;47(1):14. Epub 2018 Feb 13.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, Queen Elizabeth II Health Science Centre and Dalhousie University, 3rd Floor Dickson Building, VG Site, 5820 University Avenue, Halifax, NS, B3H 2Y9, Canada.

Background: The laryngeal framework provides a natural barrier preventing tumour spread to extralaryngeal structures. Transoral laser microsurgery (TLM) for laryngeal squamous cell carcinoma (SCC) may violate these boundaries, altering the pathways of tumor spread for potential recurrences. Our project objective is to describe laryngeal SCC recurrence patterns and overall survival in patients requiring total laryngectomy (TL) after TLM. Read More

Aust Dent J 2018 Jun 25;63(2):202-207. Epub 2018 Mar 25.

Oral and Maxillofacial Surgery Department, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.

Background: Osteonecrosis of the jaw (ONJ) is a serious complication of both radiation and antiresorptive therapies. This study aimed to determine how many patients have been treated for medication-related osteonecrosis of the jaws (MRONJ) and osteoradionecrosis (ORN), and whether the number of diagnoses has decreased over time with improved awareness and preventative measures.

Methods: Medical records at the Royal Brisbane and Women's Hospital, Gold Coast University Hospital and Robina Hospital were reviewed to identify patients diagnosed with MRONJ and ORN between January 2003 and May 2017. Read More

J Surg Oncol 2018 Apr 12;117(5):1092-1099. Epub 2018 Feb 12.

Maxillo-Facial Surgery Unit, AOU-Careggi, Florence, Italy.

Background And Objectives: Reconstruction of tongue cancer defects is challenging due to the complex anatomy and physiology of the tongue. Here, we classify patterns of tongue tissue loss and describe a treatment algorithm for achieving good functional and oncologic outcomes.

Methods: We retrospectively reviewed 50 tongue squamous-cell carcinomas surgically treated between January 2010-June 2015. Read More

J Plast Reconstr Aesthet Surg 2018 05 20;71(5):729-735. Epub 2017 Dec 20.

Department of Plastic Surgery, Medical College of Wisconsin, 1155N. Mayfair Road, Suite T2600-South Entry, Milwaukee, WI 53226, USA.

The anterolateral thigh flap (ALT) is a workhorse for a spectrum of reconstructive problems including head and neck defects. Its versatility as a chimeric flap employing a variety of soft tissues with a robust pedicle is useful for three-dimensional defects. The authors investigated the anatomical relationship between the vascular supply to the ALT and anterior femur. Read More

J Craniomaxillofac Surg 2018 Mar 8;46(3):511-520. Epub 2018 Jan 8.

Department of Cranio- and Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.

Introduction: Microvascular surgery following tumor resection has become an important field of oral and maxillofacial surgery (OMFS). Following the results from management of T1/T2 floor-of-mouth and tongue squamous cell carcinoma (SCC) in German-speaking countries, Europe, and worldwide, this paper presents specific concepts for the management of resection and reconstruction of T3/T4 SCC of the maxillary and mandibular alveolar process and tongue.

Methods: The DÖSAK questionnaire was distributed in three different phases to a growing number of maxillofacial units worldwide. Read More

Mod Pathol 2018 05 2;31(5):772-779. Epub 2018 Feb 2.

Department of Pathology, Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada.

Surgery is the mainstay of treatment for low-stage (stage I/II, ie, T1N0/T2N0) squamous cell carcinoma of oral cavity. However, a significant percentage of low-stage squamous cell carcinoma of oral cavity will develop local recurrence and disease-related mortality. In this study, we stratified 64 patients with low-stage of oral tongue and floor of mouth patients into high-, intermediate- and low-risk categories based on existing histologic risk model. Read More

Br J Oral Maxillofac Surg 2018 02 17;56(2):90-95. Epub 2018 Jan 17.

Oral/Head and Neck Pathology, Guy's Hospital, King's College London, 4th Floor, Tower Wing, London SE19RT. Electronic address:

This review of changes to the 4th edition of the WHO classification of head and neck tumours focuses on their impact on the surgical care of diseases that affect the salivary glands, jaws, and oral cavity. Updates to the chapter on the salivary glands include the addition of secretory carcinoma and sclerosing polycystic adenosis. The odontogenic cysts are back, and the odontogenic keratocyst is listed among them, as it has now lost its brief and confusing designation as a neoplasm. Read More