3,675 results match your criteria Malignant Tumors of the Floor of the Mouth


Do Clear Cell Changes in Oral Squamous Cell Carcinoma Warrant It Being Recognised as a Variant?

Cureus 2022 May 16;14(5):e25057. Epub 2022 May 16.

Oral and Maxillofacial Pathology, Ragas Dental College and Hospitals, Chennai, IND.

Histological variants of oral squamous cell carcinoma (OSCC) include verrucous, basaloid, spindle cell, adenosquamous, papillary, and acantholytic types. Clear-cell changes in OSCC are rare. We report a case of a 65-year-old male Chinese patient who presented with a swelling in the lower-left mandible for three weeks, causing ill-fitting of his lower denture and an ulcer on the floor of the mouth. Read More

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The Interrelation Among Triad of Depth of Invasion, Perineural Invasion and Tumor Size in Squamous Cell Carcinoma of Tongue and Floor of the Mouth: An Analytical Appraisal.

J Maxillofac Oral Surg 2022 Jun 18;21(2):350-357. Epub 2022 Jan 18.

Department of Head and Neck Oncology, Dr. Bhubaneswar Borooah Cancer Institute, Guwahati, India.

Background: Head and neck cancer represents 5-10% of all malignancies. Squamous cell carcinoma (SCC) of the oral cavity represents about 2% of overall malignant neoplasms and 47% of the head and neck region Squamous cell carcinoma of tongue has a peculiar behavior of occult and skips metastasis to regional lymph nodes. It occasionally occurs along with floor of the mouth. Read More

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Mucoepidermoid carcinoma: Analysis of 76 cytologic cases and correlation with histologic grade.

Authors:
Paul E Wakely

Cancer Cytopathol 2022 May 31. Epub 2022 May 31.

Department of Pathology, The Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA.

Background: Mucoepidermoid carcinoma (MEC) is the most common salivary gland (SG) malignancy. In this study, the author undertook analysis of a large collection of MEC cytologic cases.

Materials And Methods: Cytopathology files were searched for MEC cases with histopathologic confirmation. Read More

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Supercritical Carbon Dioxide Decellularized Xenograft-3D CAD/CAM Carved Bone Matrix Personalized for Human Bone Defect Repair.

Genes (Basel) 2022 Apr 25;13(5). Epub 2022 Apr 25.

R & D Center, ACRO Biomedical Co., Ltd. 2nd. Floor, No.57, Luke 2nd. Rd., Luzhu District, Kaohsiung 821011, Taiwan.

About 30-50% of oral cancer patients require mandibulectomy and autologous fibula reconstruction. Autograft is the gold standard choice because of its histocompatibility; however, it requires additional surgery from the patient and with possible complications such as loss of fibula leading to calf weakening in the future. Allograft and xenograft are alternatives but are susceptible to immune response. Read More

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Lymphoepithelial cyst in the palatine tonsil: A case report and literature review.

Medicine (Baltimore) 2022 May 20;101(20):e29246. Epub 2022 May 20.

Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea.

Rationale: Lymphoepithelial cyst of the oral cavity is very rare. Most intraoral lymphoepithelial cysts are observed in the floor of the mouth and very few cases have been reported of its occurrence in the palatine tonsil.

Patient Concerns: A 37-year-old healthy woman with no remarkable medical history visited our department with a complaint of frequent tonsillitis. Read More

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Indirect comparisons of brigatinib and alectinib for front-line -positive non-small-cell lung cancer.

Future Oncol 2022 Jun 24;18(20):2499-2510. Epub 2022 May 24.

University of Colorado Cancer Center, Anschutz Cancer Pavilion, 1665 North Aurora Ct, Mail Stop F-704, Room 5237, Aurora, CO 80045, USA.

To conduct an indirect treatment comparison (ITC) of the relative efficacy of brigatinib and alectinib for progression-free survival in people with tyrosine kinase inhibitor (TKI)-naive -positive non-small-cell lung cancer (NSCLC). Final aggregate and patient-level data from the ALTA-1L trial comparing brigatinib to crizotinib and published aggregate data from ALEX (comparing alectinib to crizotinib) were contrasted using Bucher ITC and matching-adjusted indirect comparisons (MAICs). No statistically significant differences were identified between brigatinib and alectinib in reducing the risk of disease progression overall and in patients with baseline central nervous system metastases. Read More

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Burden of cancers in India - estimates of cancer crude incidence, YLLs, YLDs and DALYs for 2021 and 2025 based on National Cancer Registry Program.

BMC Cancer 2022 May 11;22(1):527. Epub 2022 May 11.

Indian Council Medical Research (ICMR) - National Centre for Disease Informatics and Research (NCDIR), Nirmal Bhawan-ICMR Complex (II Floor), Poojanahalli, Kannamangala Post, Bengaluru, Karnataka, 562 110, India.

Background: Cancer is the major cause of morbidity and mortality worldwide. The cancer burden varies within the regions of India posing great challenges in its prevention and control. The national burden assessment remains as a task which relies on statistical models in many developing countries, including India, due to cancer not being a notifiable disease. Read More

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Large cell neuroendocrine carcinoma of the floor of mouth and retromolar trigone in association with basaloid squamous cell carcinoma.

Int J Oral Maxillofac Surg 2022 May 3. Epub 2022 May 3.

Department of Otolaryngology, Regions Hospital, St. Paul, Minnesota, USA.

Large cell neuroendocrine carcinoma and basaloid squamous cell carcinoma are each rare but aggressive diseases of the head and neck. A case of large cell neuroendocrine carcinoma occurring simultaneously with a basaloid squamous cell carcinoma originating from the oral cavity is described in this report. The diagnosis of these pathologies can be challenging but is important, as staging and treatment recommendations differ from those for oral cavity squamous cell carcinoma. Read More

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Risk Factors for Xerostomia Following Radiotherapy of Head-and-Neck Cancers.

Anticancer Res 2022 May;42(5):2657-2663

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany;

Background/aim: Many head-and-neck cancer patients receive radiotherapy, which may be associated with significant toxicities. Xerostomia is considered one of the most debilitating late adverse events. This study was performed to identify risk factors for xerostomia. Read More

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Evaluation of patients with oral squamous cell carcinoma treated by radical irradiation with mold radiotherapy using a customized device: a retrospective clinical study.

J Med Case Rep 2022 Apr 29;16(1):178. Epub 2022 Apr 29.

Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University, 3311-1 Yakushiji , Shimotsuke-shi, Tochigi, 329-0498, Japan.

Background: It is very important to determine the indication of mold radiotherapy for the radical treatment of oral cancer. We investigated eight patients with oral squamous cell carcinoma who were treated by radical irradiation with mold radiotherapy using a customized device.

Methods: The subject is a case of curable superficial oral cancer of a few millimeters, or cancer of a size that can be cured by the placement of the radiation source. Read More

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Useful diagnostic histogenetic features of ectopic odontogenic ghost cell tumours.

BMC Oral Health 2022 04 20;22(1):134. Epub 2022 Apr 20.

Department of Pathology and Laboratory Medicine, Kansai Medical University Hirakata Hospital, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.

Background: Ectopic odontogenic tumours are rare and difficult to diagnose. Consequently, they are occasionally misdiagnosed as other tumours and overtreated. Dentinogenic ghost cell tumours (DGCTs) are odontogenic neoplasms characterised by a CTNNB1 mutation, ghost cell appearance, and dentinoid-like calcification. Read More

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[Clinical analysis of selective tracheostomy necessary for patients undergoing head and neck surgery with free flap reconstruction].

Beijing Da Xue Xue Bao Yi Xue Ban 2022 Apr;54(2):363-368

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry & NMPA Key Laboratory for Dental Materials, Beijing 100081, China.

Objective: To discover the factors that may affect the use of selective tracheostomy among patients who have undergone head and neck surgeries with free flap reconstruction, so that the patients will not need tracheostomy nor receive the unnecessary treatment.

Methods: Five hundred and thirty-three patients who had undergone head and neck surgery with free flap reconstruction operated by the same team of surgery at Department of Oral and Maxillofacial Surgery at Peking University School of Stomatology from 2015 to 2016 were reviewed. Three hundred and twenty-one (60. Read More

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Head and neck squamous cell carcinoma: evaluation of iodine overlay maps and low-energy virtual mono-energetic images acquired with spectral detector CT.

Clin Radiol 2022 06 26;77(6):e425-e433. Epub 2022 Mar 26.

University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Diagnostic and Interventional Radiology, Cologne, Germany.

Aim: To evaluate the diagnostic value of spectral detector computed tomography (SDCT)-derived iodine overlay maps and low-energy virtual mono-energetic images (VMI) for the initial locoregional assessment of primary, therapy-naive head and neck cancer.

Materials And Methods: Fifty-six patients with histologically confirmed untreated squamous cell carcinoma of the head and neck who underwent SDCT of the neck for staging purposes were included in this retrospective study. Attenuation, image noise as well as signal- and contrast-to-noise ratios (S-/CNR) in VMI were obtained from region of interest (ROI)-based measurements in the tumour and important anatomical landmarks (sternocleidomastoid muscle, subcutaneous fat, thyroid gland, submandibular gland, carotid artery, and jugular vein). Read More

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Thyroglossal Duct Cyst in the Suprasternal Region.

Ear Nose Throat J 2022 Mar 24:1455613221086037. Epub 2022 Mar 24.

Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and 65722Chonnam National University Hospital, Gwangju, Republic of Korea.

A thyroglossal duct cyst (TGDC) is the most common congenital anterior neck mass. It can develop from residual tissue not degenerated during development and is mainly diagnosed in pediatric patients. However, a TGDC is sometimes diagnosed for the first time in adult patients. Read More

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Oral basaloid squamous cell carcinoma: A case report with emphasis on histopathological diagnosis criteria.

Oral Oncol 2022 04 10;127:105814. Epub 2022 Mar 10.

School of Dentistry, Tiradentes University, Aracaju, Sergipe, Brazil; Institute of Research and Technology, Laboratory of Morphology and Experimental Pathology, Aracaju, Sergipe, Brazil. Electronic address:

Basaloid squamous-cell carcinoma (BSCC) is an uncommon variant of squamous cell carcinoma (SCC) consisting of atypical squamous and basaloid cells. It is an aggressive lesion that most commonly affects the oropharynx, being rare in intraoral sites. In this paper, we report the case of a male patient, 42 years old, smoker and chronic drinker, presenting a vegetating and ulcerated leukoerythroplastic lesion, asymptomatic, with five months of evolution, located on the floor of the mouth. Read More

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Clinicopathological and prognostic profile of non-smoking and non-drinking head and neck cancer patients: a population-based comparative study.

Oral Oncol 2022 04 7;127:105799. Epub 2022 Mar 7.

Oral Oncology Center, São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio St, SP 15050-015 Araçatuba, São Paulo, Brazil; Department of Diagnosis and Surgery, São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio St, SP 15050-015 Araçatuba, São Paulo, Brazil. Electronic address:

Tobacco and alcohol consumption are the main risk factors for head and neck cancer (HNC). However, some individuals do not have a history of addiction and even so they develop the disease. This study evaluated clinicopathological and prognostic features of non-smoking and non-drinking (NSND) HNC patients. Read More

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Tetraspanin CD9: A friend or foe of head and neck cancer (Review).

Oncol Rep 2022 May 10;47(5). Epub 2022 Mar 10.

Central Research Laboratory, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka 575018, India.

Head and neck cancers are diverse and complex diseases characterised by unregulated growth of tumour cells in various parts of the head and neck region, such as in the buccal mucosa, floor of the mouth, tongue, oropharynx, hypopharynx, oesophagus, nasopharynx and salivary glands. Partial or total glossectomy, radiation or chemotherapy greatly affect patient quality of life. However, even following treatment, patients may relapse. Read More

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Endoscopic-Assisted Transoral Thyroglossal Cyst Resection.

Front Endocrinol (Lausanne) 2021 18;12:774174. Epub 2022 Feb 18.

Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Sistrunk procedure is the standard method for thyroglossal duct cyst resection. While this procedure is successful and safe, it results in postoperative scars on the front of neck. We propose a total transoral technique without external incision that starts with careful separation of the floor of the mouth and genioglossus muscle followed by the exact localization of the cyst using methylene blue. Read More

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Using machine learning and an electronic tongue for discriminating saliva samples from oral cavity cancer patients and healthy individuals.

Talanta 2022 Jun 22;243:123327. Epub 2022 Feb 22.

São Carlos Institute of Physics (IFSC), University of São Paulo (USP), 13566-590, São Carlos, SP, Brazil. Electronic address:

The diagnosis of cancer and other diseases using data from non-specific sensors - such as the electronic tongues (e-tongues) - is challenging owing to the lack of selectivity, in addition to the variability of biological samples. In this study, we demonstrate that impedance data obtained with an e-tongue in saliva samples can be used to diagnose cancer in the mouth. Data taken with a single-response microfluidic e-tongue applied to the saliva of 27 individuals were treated with multidimensional projection techniques and non-supervised and supervised machine learning algorithms. Read More

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Mass on the Floor of the Mouth in a Teenager.

Pediatr Rev 2022 Mar;43(3):e9-e11

University of Texas Southwestern Medical Center, Dallas, TX.

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Functional analysis of the airways after pulmonary lobectomy through computational fluid dynamics.

Sci Rep 2022 02 28;12(1):3321. Epub 2022 Feb 28.

TBMLab - Laboratorio di Tecnologie Biomediche, Dipartimento di Elettronica, Informazione e Bioingegneria (DEIB), Politecnico Di Milano, Via Colombo, 40 (2° floor), 20133, Milan, Italy.

Pulmonary lobectomy, which consists of the partial or complete resection of a lung lobe, is the gold standard intervention for lung cancer removal. The removal of functional tissue during the surgery and the re-adaptation of the remaining thoracic structures decrease the patient's post-operative pulmonary function. Residual functionality is evaluated through pulmonary function tests, which account for the number of resected segments without considering local structural alterations and provide an average at-the-mouth estimation. Read More

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February 2022

[Application of trifoliate flap design of radial forearm flap in reconstruction of defects after mouth floor cancer resection].

Zhonghua Zhong Liu Za Zhi 2022 Feb;44(2):192-196

The 2nd Department of Head and Neck Surgery, Department of Oncoplastic Surgery, Hunan Cancer Hospital & the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.

To evaluate the effect of trifoliate flap design of radial forearm flap in reconstruction of defects after mouth floor cancer resection. From June 2016 to December 2019, 12 patients with defect after resection of mouth floor cancer were treated with trifoliate flap design of radial forearm flap. All of these patients were T2 stage, included 9 well-differentiated squamous cell carcinoma (SCC) and 3 moderate differentiated SCC. Read More

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February 2022

Influence of Treatment Package Time on outcomes in High-Risk Oral Cavity Carcinoma in patients receiving Adjuvant Radiation and Concurrent Systemic Therapy: A Multi-Institutional Oral Cavity Collaborative study.

Oral Oncol 2022 03 17;126:105781. Epub 2022 Feb 17.

Department of Radiation Oncology, Henry Ford Cancer Institute, Detroit, MI, USA. Electronic address:

Objectives: To explore the influence of treatment package time(TPT) in high-risk oral cavity squamous cell carcinoma(OCSCC) receiving adjuvant radiotherapy with concurrent chemotherapy(CRT).

Materials And Methods: We queried our multi-institutional OCSCC collaborative database for cases diagnosed between 2005 and 2015 who underwent surgery followed by adjuvant CRT. All patients had high-risk features: extranodal extension(ENE) and/or positive surgical margin(PM). Read More

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DNA damage-related proteins in smokers and non-smokers with oral cancer.

Braz Oral Res 2022 9;36:e027. Epub 2022 Feb 9.

Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery, Pathology and Clinical Dentistry, Belo Horizonte, MG, Brazil.

Tobacco smoking involves a high risk of human malignancies, including oral cancer, because it contains multiple carcinogens that cause genetic instability. Thus, a worse prognosis would be expected for cancer patients who are smokers. The aim of this study was to assess the DNA damage response through the expression of checkpoint kinase 2 (CHK2), H2A histone family member X (H2AX), and P53 among smokers and non-smokers with oral squamous cell carcinoma (OSCC). Read More

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February 2022

[Clinicopathological study in 28 cases of oral basaloid squamous cell carcinomas].

Beijing Da Xue Xue Bao Yi Xue Ban 2022 Feb;54(1):62-67

Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry & NMPA Key Laboratory for Dental Materials, Beijing 100081, China.

Objective: To investigate the clinicopathologic features and prognostic factors in oral basaloid squamous cell carcinoma.

Methods: Retrospective analysis of oral basaloid squamous cell carcinomas patients who underwent tumor resection during the period from January 2002 to December 2020 in the authors' hospital, especially the clinicopathologic characteristics of 28 cases with confirmed diagnosis and follow-up data. Immunohistochemistry was performed to define the helpful markers for differentiation diagnosis. Read More

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February 2022

Adenocarcinoma not otherwise specified (NOS) arising in the sublingual gland: Rare case report and follow-up.

Oral Oncol 2022 03 2;126:105754. Epub 2022 Feb 2.

Oral Semiology and Oral Pathology, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. Electronic address:

Background: Adenocarcinoma not otherwise specified (AdCaNOS) is a rare malignant salivary gland tumor that occurs with higher frequency in the parotid gland of male patients. In this study, we described a second case of AdCaNOS arising in the sublingual gland, in a female patient with 39 years of age, highlighting the clinical, radiographic, microscopic, treatment features and follow-up.

Case Report: A 39-year-old female patient presented a fibroelastic nodule with a yellowish coloration, in the left region of the floor of mouth, measuring about 4. Read More

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Surgical margins in the resection of oral squamous cell carcinoma under local versus general anesthesia.

Oral Oncol 2022 02 19;125:105724. Epub 2022 Jan 19.

Department of Oral and Maxillofacial Surgery and Special Dental Care, University Medical Center Utrecht, the Netherlands; Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address:

Objectives: This study analyzes the influence of the surgical setting, i.e. resection under local anesthesia versus resection under general anesthesia, on surgical margins in tumor resection of stage I and II oral squamous cell carcinoma (OSCC). Read More

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February 2022

[Mass Screening of Oral Cancer in Eastern Shimane Prefecture during 2015-2019].

Gan To Kagaku Ryoho 2021 Dec;48(13):2094-2097

Dept. of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine.

The Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, has been conducting mass screening of oral cancer using oral abrasion cytology by oral surgeons in eastern Shimane prefecture for public awareness and its early detection. As a result, 3(0.09%)cases of oral cancer were identified. Read More

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December 2021

Desmoglein-3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells.

Mol Oncol 2022 04 1;16(8):1625-1649. Epub 2022 Mar 1.

Centre for Oral Immunobiology and Regenerative Medicine, Institute of Dentistry, Barts and The London, School of Medicine and Dentistry, UK.

Alterations of the Hippo-YAP pathway are potential targets for oral squamous cell carcinoma (OSCC) therapy, but heterogeneity in this pathway could be responsible for therapeutic resistance. We analysed the Hippo-YAP signatures in a cohort of characterised keratinocyte cell lines derived from the mouth floor and buccal mucosa from different stages of OSCC tumour progression and focused on the specific role of YAP on invasive and metastatic potential. We confirmed heterogeneity in the Hippo-YAP pathway in OSCC lines, including overexpression of YAP1, WWTR1 (often referred to as TAZ) and the major Hippo signalling components, as well as the variations in the genes encoding the intercellular anchoring junctional proteins, which could potentially regulate the Hippo pathway. Read More

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Reirradiation Using Au Grain Brachytherapy for Recurrent Oral Cancer Cases Previously Treated by Definitive Radiotherapy.

Anticancer Res 2022 Jan;42(1):293-300

Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Background/aim: We investigated treatment outcomes and complications during reirradiation of patients with oral cancers.

Patients And Methods: Six patients who received definitive radiotherapy for oral cancer as the initial treatment and brachytherapy for recurrence were included. Local control and overall survival rates, soft tissue and mandibular complications, and tooth extraction were investigated. Read More

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January 2022