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Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Mar;35(3):204-208

Department of Otorhinolaryngology，the First Affiliated Hospital，Nanjing Medical University，Nanjing，210029，China.

To summarize and analyze the feasibility, safety and efficacy of parapharyngeal space surgery assisted by coblation and endoscopic system with transoral approach. The data of 20 patients with parapharyngeal space tumors were retrospectively analyzed. All the patients underwent CT and/or MRI examination before surgery, and all underwent transoral approach assisted by coblation and endoscopic systems. Read More

Anticancer Res 2021 Mar;41(3):1157-1161

Department of Oto-Rhino-Laryngology, Klinikum Maria Hilf, Mönchengladbach, Germany.

Background/aim: While in many Western countries the number of tonsillectomies decreases significantly, there is an increasing incidence of oropharyngeal carcinomas. For, obviously, removal of the tonsils will reduce individual risk for tonsil cancer, the question of tonsillectomy as a prevention strategy is suggested. This study focused on this question by carrying out a literature research. Read More

Ann R Coll Surg Engl 2021 Mar;103(3):e85-e87

Head and Neck & Skull Base Centre, King Abdullah Medical City, Mecca, Saudi Arabia.

Epidermolysis bullosa simplex (EBS) is a debilitating condition affecting the skin and mucous membranes that is characterised by frequent ulceration and blistering on trivial trauma. In EBS, oral cavity mucosal injuries lead to a high propensity for developing squamous cell carcinomas. Locally advanced tongue carcinoma arising in this background presents a challenging therapeutic conundrum. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Feb;35(2):172-173

Osteoma of lingual base is a rare disease which consists of well-developed bone surrounded by epithelial tissue on the surface of tongue. This article reported a case of osteoma of lingual base in the oral-cavity. The patient was admitted to hospital on March 2019 and developed foreign body sensation in pharynx in the last 2 weeks, without pharyngeal pain and fever, cough and sputum, breathing and swallowing difficulties. Read More

Gan To Kagaku Ryoho 2020 Dec;47(13):2225-2226

Dept. of Surgery, Numazu City Hospital.

The case was a woman in her 50s. Total pelvic resection was performed for advanced rectal cancer(cT4b[vagina]N3M0, cStage Ⅲc), after neoadjuvant chemoradiation therapy. Five months after the operation, she was unable to stand due to severe back pain. Read More

BMJ Case Rep 2021 Jan 18;14(1). Epub 2021 Jan 18.

Department of Otolaryngology, Head and Neck Surgery, University of Malaya, Kuala Lumpur, Malaysia.

Lipoblastomas are benign tumours of immature fat cells presenting in infancy. A lipoblastoma within the airway lumen causing airway compromise is an extremely rare occurrence. We present a 6 hours of life girl who had airway compromise due to a lobulated mass at the base of the tongue. Read More

Lasers Med Sci 2021 Jan 3. Epub 2021 Jan 3.

Biomedical Robotics Lab, Department of Advanced Robotics, Istituto Italiano di Tecnologia, Genoa, Italy.

In the last decades, new technological devices and instruments have been developed to overcome the technical limits of transoral laser microsurgery. The recent introduction of 3D endoscopy seems to be a promising tool in the field of diagnostic and operative laryngology as an alternative to the traditional microlaryngoscopy. Our work aims to present a novel transoral microsurgical setting that expands the use of exoscopic systems (in this case the VITOM® 3D-HD) as an alternative to the standard operating microscope. Read More

World J Clin Cases 2020 Nov;8(22):5663-5669

Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8549, Japan.

Background: Oral mucositis is often observed with graft-versus-host disease (GVHD); however, the occurrence of oral granuloma is rare. The rapid increase in granulomatous lesions should be distinguished from malignant tumors in patients with GVHD because malignant diseases can develop in those patients. This case is the youngest pediatric patient with granuloma associated with GVHD. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Dec;55(12):1126-1130

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

To evaluate clinical applications and efficacy of submental artery perforator flap in reconstruction surgery after removal of pharyngeal carcinoma. A total of 27 patients in the Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University were included, 23 males and 4 females with age from 40 to 70 years old, and 17 patients were hypopharyngeal carcinoma (HPC) and 10 patients were oropharyngeal carcinoma (OPC). All patients underwent tumor resection followed by simultaneously reconstruction surgery using submental artery perforator flap between January 2015 and December 2019. Read More

BMJ Case Rep 2020 Dec 17;13(12). Epub 2020 Dec 17.

Department of Pediatrics, University of California San Diego, La Jolla, California, USA.

A 2-month-old full-term female infant with medical history of situs inversus totalis presented to the emergency department with congestion and abnormal breathing. She was discovered to have failure to thrive (FTT) and subsequently admitted. Investigations revealed a large vallecular mass at the base of her tongue which was noted to cause severe, intermittent airway obstruction. Read More

Cancer 2021 Apr 11;127(8):1228-1237. Epub 2020 Dec 11.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Risk of recurrence among patients with oropharyngeal cancer (OPC) who survive 5 years is low. The goal of this study was to assess long-term survival of patients with OPC alive without recurrence 5 years after diagnosis.

Methods: This study included newly diagnosed patients with OPC, who had been treated with radiation and were alive without recurrence 5 years after diagnosis. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Oct;34(10):937-941

Department of Otorhinolaryngology，the First Affiliated Hospital of Chongqing Medical University，Chongqing，400012，China.

To analyze the imaging features of parapharyngeal space tumors, and to guide the choice of treatment. A retrospective analysis of 75 cases' clinical data of parapharyngeal space tumor was carried out. All patients underwent enhanced CT and/or enhanced MRI, those tumors closely related to blood vessels and vascular tumors were examined by CTA or MRA, those closely related to peripheral nerves were examined by MRN. Read More

Arch Gynecol Obstet 2021 02 27;303(2):329-335. Epub 2020 Nov 27.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

Purpose: Three human papillomavirus (HPV) vaccines are available against up to nine HPV types. In Sweden, from 2012, Gardasil was offered to 10-12 year old girls through the school-based vaccination program, and as catchup vaccination for women up to 26 years. To obtain a baseline, and follow HPV vaccination effects, during 2008-2018, cervical and oral HPV prevalence were followed at a youth clinic in Stockholm, and in 2013 for comparison oral HPV prevalence was examined in high-school youth in a middle-sized county in Sweden. Read More

Radiother Oncol 2021 04 18;157:63-69. Epub 2020 Nov 18.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States.

Purpose: To introduce a contouring guideline for the taste bud bearing tongue mucosa for head and neck cancer patients receiving radiotherapy.

Methods And Materials: CT simulation images of oropharyngeal cancer patients were used to delineate both the whole tongue (extrinsic/intrinsic tongue muscles, floor of mouth) and the taste bud bearing tongue mucosa (method A: adaptation of the whole tongue structure; method B: axial adaptation of a mid-sagittal contour). Volumetric and dosimetric parameters of the whole tongue and the two methods of mucosal delineation, spatial overlap between methods A and B, and inter-observer variability for method B were calculated. Read More

BMJ Case Rep 2020 Oct 22;13(10). Epub 2020 Oct 22.

Division of Otolaryngology-Head and Neck Surgery, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.

A 74-year-old man was referred to a tertiary academic otolaryngology clinic for evaluation of a left-sided neck mass with unknown primary. Nuclear imaging modalities revealed a primary cancer located at the left tongue base. Further investigation revealed the tumour to be a p16 positive squamous cell cancer with metastatic spread to cervical lymph nodes of multiple levels. Read More

Medicina (Kaunas) 2020 10 13;56(10). Epub 2020 Oct 13.

Faculty of Medicine and Dentistry, Health Research, Institute of Santiago de Compostela (Instituto de Investigación Sanitaria de Santiago, IDIS), Oral Medicine, Oral Surgery and Implantology University, Santiago de Compostela University, 15782 Santiago de Compostela, Spain.

Head and Neck Squamous Cell Carcinoma (HNSCC) includes cancers from the oral cavity, larynx, and oropharynx and is the sixth-most common cancer worldwide. MicroRNAs are small non-coding RNAs for which altered expression has been demonstrated in pathological processes, such as cancer. The objective of our study was to evaluate the different expression profile in HNSCC subtypes and the prognostic value that one or several miRNAs may have. Read More

Sci Rep 2020 10 12;10(1):17039. Epub 2020 Oct 12.

Laboratory of Cancer Genetics, School of Medical Sciences, University of Campinas, Rua Vital Brasil, 50, Distrito de Barão Geraldo, Campinas, São Paulo, CEP: 13083-888, Brazil.

We conducted a two-stage association study on patients with oropharynx (OP) squamous cell carcinoma (SCC) and healthy controls to identify single nucleotide variants (SNVs) located at the microRNA (miR)-binding sites of carcinogenesis genes associated with risk and prognosis of the disease. In stage 1, 49 patients and 49 controls were analyzed using Genome-Wide Human SNV Arrays to identify variants in the 3'-untranslated region (3'-UTR) of carcinogenesis-related genes, and one SNV was selected for data validation in stage 2 by TaqMan assays in 250 OPSCC patients and 250 controls. The ERP29 c. Read More

Strahlenther Onkol 2021 Mar 9;197(3):209-218. Epub 2020 Oct 9.

Department of Radiation Oncology, University Hospital S. Chiara, Via Roma 55, 56100, Pisa, Italy.

Purpose: To develop a videofluoroscopy-based predictive model of radiation-induced dysphagia (RID) by incorporating DVH parameters of swallowing organs at risk (SWOARs) in a machine learning analysis.

Methods: Videofluoroscopy (VF) was performed to assess the penetration-aspiration score (P/A) at baseline and at 6 and 12 months after RT. An RID predictive model was developed using dose to nine SWOARs and P/A-VF data at 6 and 12 months after treatment. Read More

Photodiagnosis Photodyn Ther 2020 Dec 2;32:102048. Epub 2020 Oct 2.

Key Laboratory of the Ministry of Education for Optoelectronic Measurement Technology and Instrument, Beijing Information Science and Technology University, Beijing, 100192, China. Electronic address:

The research is to propose a new classification framework, called diverse spectral band-based deep residual network (DSB-ResNet), which can distinguish tongue squamous cell carcinoma (TSCC) from non-cancerous tissue. A fiber optic Raman spectroscopy system is used to collect Raman spectral data of TSCC and normal tissues. DSB-ResNet takes advantage of diverse spectral band-based spectra without processing to derive spectral representations from different spectral bands of Raman spectra, which improves the ability to identify TSCC. Read More

Rev Bras Epidemiol 2020 16;23:e200094. Epub 2020 Sep 16.

Community Dentistry Department, School of Dentistry, Universidade de São Paulo - São Paulo (SP), Brazil.

Introduction: Poor oral hygiene, regular use of mouthwash and absence of visits to the dentist could correspond to potential risk factors for the development of head and neck cancer.

Objective: The objective of this study was to determine whether oral hygiene is associated with the occurrence of oral cavity and head and neck cancer in a Brazilian sample.

Method: The variables of oral hygiene condition, such as toothbrushing frequency, dental loss, need and use of prosthesis, and regular visit to the dentist in a case-control study were analyzed in patients from five hospitals in the state of São Paulo, Brazil, paired by gender and age, from the multicenter project Genoma do Câncer de Cabeça e Pescoço (GENCAPO). Read More

Laryngoscope 2021 04 21;131(4):E1345-E1348. Epub 2020 Sep 21.

Division of Pediatric Otolaryngology-Head and Neck Surgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, U.S.A.

Eur J Cancer 2020 11 17;139:192-200. Epub 2020 Sep 17.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Pathology, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

Background: TNM-8 staging separates oropharyngeal squamous cell carcinomas (OPSCC) into human papillomavirus (HPV)-mediated and -unrelated OPSCC based on p16INK4a overexpression (p16+), as surrogate marker for HPV. However, OPSCC is histologically and clinically heterogenous including tonsillar and base of tongue squamous cell carcinomas (TSCC and BOTSCC respectively), and carcinomas of soft palate and walls (otherOPSCC). The significance of HPV is established in TSCC/BOTSCC, while its role in otherOPSCC is unclear, which is not considered in TNM-8. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2020 Jun;40(6):814-821

Department of Stomatology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.

Objective: To evaluate the effect of using free double- leaf perforator flap posterolateral calf peroneal artery in anatomical reconstruction of the oropharyngeal structure after ablation of advanced oropharyngeal carcinoma.

Methods: Twenty-six patients with oropharyngeal defects after ablation of oropharyngeal malignancies were recruited, including 12 with carcinoma in the tongue base, 5 in the latenral pharyngeal wall and 9 in the soft palate. Between July, 2016 and July, 2018, the patients underwent surgeries for reconstruction of the oropharyngeal defects using flaps. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 08;34(8):752-754

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Jun;34(6):508-511

Department of Ophthalmology and Otorhinolaryngology，Lhasa People's Hospital.

To investigate the feasibility of semi-free transverse cervical artery flaps for repairing the defect of head and neck tumors after operation. Clinical records of 15 patients were retrospectively reviewed. Ten cases were diagnosed as oral cancer, 4 cases as hypopharyngeal carcinoma and 1 case as orbito-facial mucinous adenocarcinoma. Read More

Radiother Oncol 2020 10 13;151:110-117. Epub 2020 Aug 13.

Univeristy of British Columbia, Vancouver, BC, Canada; BC Cancer - Centre for the North, Prince George, BC, Canada; University of Northern British Columbia, BC, Canada.

Introduction: The incidence of immunosuppression in patients with oropharynx head & neck squamous cell carcinoma (SCC) is not well studied. This study evaluates disease characteristics and treatment outcomes in oropharynx SCC in patients with and without immunosuppression.

Methods: A retrospective review of all patients treated with radiotherapy for oropharynx SCC at BC Cancer from 2011 to 2016 was performed. Read More

Am J Case Rep 2020 Jul 28;21:e925716. Epub 2020 Jul 28.

Department of Otorhinolaryngology-Head and Neck Surgery, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.

BACKGROUND Rosai-Dorfman disease (RDD), is a rare, benign, proliferative, histiocytic disorder characterized by persistent massive lymphadenopathy, which mimics malignant tumors. Diagnosis of extranodal RDD without lymphadenopathy is difficult due to its unusual clinical manifestation and lack of typical histopathologic features. Hence, it requires both a high degree of clinical suspicion and careful histopathologic examination. Read More

Int J Oral Maxillofac Surg 2021 Mar 2;50(3):323-326. Epub 2020 Aug 2.

Department of Oral and Maxillofacial Surgery, Hospital Universitario Ramón y Cajal, Madrid, Spain; Hospital Universitario Puerta de Hierro, Majadahonda, Spain; Universidad de Alcalá de Henares, Madrid, Spain. Electronic address:

The concept of a flow-through flap refers to a free flap in which both the proximal and distal ends of the vascular pedicle are anastomosed to provide blood flow to the distal tissues. The purpose of this paper is to highlight the use of this technique, which may be useful in selected cases of head and neck reconstruction. In certain situations, like bilateral resection of the base of the tongue involving both lingual arteries, the application of a flow-through forearm free flap can provide an anatomical and functional restoration of the defect while revascularizing the anterior two-thirds of the tongue. Read More

Anticancer Res 2020 Aug;40(8):4207-4214

Head and Neck Institute, Cleveland Clinic, Cleveland, OH, U.S.A.

Background/aim: To assess factors that predict detection of tumors and oncologic outcomes in head and neck squamous cell carcinoma of unknown primary (SCCUP).

Patients And Methods: This was a retrospective cohort study at a single tertiary care institution.

Results: The primary site was detected at examination under anesthesia (EUA) in 92 (51. Read More