Am J Surg Pathol 2022 Feb 24. Epub 2022 Feb 24.
Department of Pathology, Faculty of Medicine in Plzen, Charles University Bioptic Laboratory Ltd Molecular and Genetic Laboratory, Bioptic Laboratory Ltd, Plzen Department of Pathology, Tomas Bata Hospital, Zlin, Czech Republic Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU) Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen Departments of Pathology Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Solitary fibrous tumor (SFT) is a rare fibroblastic neoplasm with potentially malignant behavior that may develop in any anatomic site and may involve the head and neck (H&N) region as well. Although typical SFT has a relatively characteristic morphology, its morphologic spectrum is extraordinarily broad and also includes rare cases with dedifferentiation or transdifferentiation which result in aberrant morphologic and/or immunohistochemical features. However, since virtually all cases are molecularly characterized by NAB2::STAT6 gene fusions, molecular genetic methods or STAT6 immunohistochemistry can be effectively used in confirming the diagnosis. Read More