Search Our Scientific Publications & Authors

Allergy Rhinol (Providence) 2020 Jan-Dec;11:2152656720920600. Epub 2020 Apr 20.

Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana.

Background: Epithelial-myoepithelial carcinomas make up less than 0.1% of head and neck malignancies and are regarded as rare, low-grade malignant neoplasms of the salivary gland. They are thought to arise from intercalated ducts with histopathology showing a classic biphasic morphology of an outer layer of myoepithelial cells and inner layer of epithelial cells. Read More

MMWR Morb Mortal Wkly Rep 2020 Apr 17;69(15):433-438. Epub 2020 Apr 17.

Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC.

Cancers of the oral cavity and pharynx account for 3% of cancers diagnosed in the United States* each year. Cancers at these sites can differ anatomically and histologically and might have different causal factors, such as tobacco use, alcohol use, and infection with human papillomavirus (HPV) (1). Incidence of combined oral cavity and pharyngeal cancers declined during the 1980s but began to increase around 1999 (2,3). Read More

Braz Oral Res 2020 6;34:e032. Epub 2020 Apr 6.

Universidade Federal de Minas Gerais - UFMG, Hospital das Clínicas, Department of Surgery of the School of Medicine and Head and Neck Surgery, Belo Horizonte, MG, Brazil.

About 92,000 new cases of oropharynx carcinoma are expected to occur annually worldwide. There is no consensus about the best therapy for these advanced tumors. The objective of the present study was to evaluate overall and disease-free survival rates of patients with advanced oropharynx squamous cell carcinoma, comparing surgery + radiotherapy with chemotherapy + radiotherapy. Read More

Korean J Intern Med 2020 Apr 3. Epub 2020 Apr 3.

Division of Hematology-Oncology, Department of Medicine, , Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background/aims: Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over current chemoradiotherapy (CRT) in patients with hypopharynx and BOT cancer. Read More

Tech Innov Patient Support Radiat Oncol 2020 Jun 28;14:1-10. Epub 2020 Feb 28.

Department of Radiation Oncology, Olivia Newton John Cancer Wellness & Research Centre, Austin Health, Heidelberg, Victoria, Australia.

Introduction: To identify organs to which dose limitation using intensity modulated radiotherapy (IMRT) can potentially modify the incidence and duration of feeding tube use, during and immediately following therapy for head and neck cancer.

Materials And Methods: One hundred and fourteen patients treated with definitive IMRT (± concurrent chemotherapy) head and neck mucosal cancers were included. Patients received a prophylactic feeding tube and followed up by a dietician for at least eight weeks post-radiotherapy. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;55(2):109-115

Department of Otorhinolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

To evaluate the indication, safety and effectiveness of transoral robotic surgery (TORS) for oropharyngeal cancer based on our preliminary experience. Twelve patients, including six with tonsil cancer, five with tongue base cancer and one with posterior pharyngeal wall cancer, who underwent TORS with Da Vinci Si surgical system from March 2017 to October 2018 at Tongji Hospital of Huazhong University of Science Technology were respectively analyzed. And the surgical time, intraoperative blood loss, postoperative local bleeding, dyspnea, nerve function injury, oral intake time, whether or not to receive chemoradiotherapy were analyzed. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;55(2):87-93

Department of Otorhinolaryngology Head and Neck Surgery, the Affiliated Hospital of Qingdao University, Otorhinolaryngology Head and Neck Surgery Key Laboratory of Shandong Province, Qingdao 266003, China; Department of Skull Base Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266003, China; Department of Allergy, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.

To explore the application of endoscopy and clinical effect of endoscopic resection of benign tumor in infratemporal fossa. The clinical data of 11 patients with benign tumors in infratemporal fossa admitted to the Department of Otorhinolaryngology Head and Neck Surgery and Skull Base Surgery of the Affiliated Hospital of Qingdao University from January 2016 to September 2018 were retrospectively analyzed. There were 6 males and 5 females, with the age ranging from 11 to 63 years old. Read More

Med Oral Patol Oral Cir Bucal 2020 May 1;25(3):e403-e409. Epub 2020 May 1.

Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Odontologia, Rua Ramiro Barcelos, 2492, sala 503, CEP: 90035-003 Santana, Porto Alegre RS, Brazil

Background: To analyze the trends of oral and oropharyngeal cancer mortality in Uruguay between 1997 and 2014 according to sex and age groups and its possible association with sociodemographic factors.

Material And Methods: A time-series ecological study using secondary data was performed. The data about mortality due to oral and oropharyngeal cancers were obtained from the Statistics Vitals Department of the Public Health Ministry of Uruguay. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Dec;54(12):907-911

Department of Head and Neck Surgery, Sichuan Cancer Hospital, Sichuan Institute of Cancer Research, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.

To explore the advantages and clinical efficacy of free chimeric perforator flap based on the descending branch of circumflex femoral artery applied to tongue reconstruction after advanced tongue cancer resection. From October 2013 to December 2018, 57 cases received tongue and oral base reconstruction surgeries using the descending branch of circumflex femoral artery chimeric perforator flap, including 39 males and 18 females, ranged from 20 to 76 years old. And all cases were with stage T3 and T4 tongue cancers, including 35 cases of squamous cell carcinoma, 7 cases of low differentiation cancer, 5 cases of oncosarcoma, and 10 cases of adenoid cystic carcinoma. Read More

World Neurosurg 2020 Mar 9;135:205-208. Epub 2019 Dec 9.

Department of Neurosurgery. Hospital Universitario de Caracas, Caracas, Venezuela.

Background: Hypoglossal schwannomas are rare, benign intracranial neoplasms; they represent 5% of all nonvestibular schwannomas.

Case Description: A 22-year-old male patient had presented 4 months before admission with left-sided hearing loss, an increase in the base of support with lateralization to the left, and dysphagia to solids. Physical examination on admission showed hypotrophy of the tongue and deviation to the left. Read More

Allergy Rhinol (Providence) 2019 Jan-Dec;10:2152656719889030. Epub 2019 Nov 20.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors which most often arise from the minor salivary glands primarily in palate and tongue but can arise in any location with minor salivary glands including the nasopharynx.

Methods: A case report of primary nasopharyngeal HCCC is presented. Because of the rarity of this tumor and location, a literature search was conducted to determine the most common presenting symptoms, treatment strategies, and outcomes. Read More

J Appl Oral Sci 2020 28;28:e20190166. Epub 2019 Nov 28.

Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Odontologia, Porto Alegre, Rio Grande do Sul, Brasil.

Other: Oral and oropharyngeal cancer is considered a public health problem in several countries due to its high incidence and mortality rate.

Objective: This study aimed to analyze oral and oropharyngeal cancer mortality in Uruguay from 1997 to 2014 by age, sex and country region.

Methodology: A time series ecological study using secondary data was performed. Read More

BMJ Case Rep 2019 Nov 24;12(11). Epub 2019 Nov 24.

Otolaryngology Head and Neck Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

We present a case of a 61-year-old woman who suffered a haemorrhagic complication of an aneurysmal left lingual artery, secondary to fibromuscular dysplasia, following transoral robotic surgery (TORS). She was admitted through the emergency department 3 days after resection of a central base of tongue tumour. She suffered a massive haemorrhage requiring intensive care admission, blood transfusion, intubation, operative and endovascular intervention. Read More

J Otolaryngol Head Neck Surg 2019 Nov 12;48(1):62. Epub 2019 Nov 12.

Department of Pathology, Anatomy and Laboratory Medicine, West Virginia University, 1 Medical Center Drive, Health Sciences North, Rm 4054, Morgantown, WV, 26506, USA.

Background: Transoral robotic and laser surgery is rising in popularity due to the increasing incidence of Human Papilloma Virus (HPV) related oropharyngeal cancer. However, adequate exposure of the tongue base remains a major hurdle in many cases. This study introduces a novel surgical technique called the Floor of Mouth Window, which can be used to improve tongue base exposure at the time of transoral surgery. Read More

World J Surg Oncol 2019 Nov 9;17(1):184. Epub 2019 Nov 9.

Department of Oral and Craniomaxillofacial Surgery, University Hospital Basel, Spitalstrasse 21, CH-4031, Basel, Switzerland.

Background: Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare self-limiting condition of the oral mucosa. The lesion manifests as an isolated ulcer that can be either asymptomatic or associated with mild to severe pain, and in most cases, it affects the tongue. TUGSE lesions may mimic malignancy such as squamous cell carcinoma, CD30 positive lymphoproliferative disorder, or infectious diseases such as primary syphilis, tuberculosis, or Epstein-Barr virus mucocutaneous ulcer. Read More

Hum Genet 2019 Dec 2;138(11-12):1379-1389. Epub 2019 Nov 2.

Institute of Medicine, Chung Shan Medical University, 110 Chien-Kuo N. Road, Section 1, Taichung, 402, Taiwan.

Betel quid (BQ) chewing is a prevailing risk for oral squamous cell carcinoma (OSCC) in Southeast Asia. Yet, the detailed mechanisms by which BQ chewing damages the genome are still not fully understood. Through exome sequencing of tumor-normal pairs from 196 male patients with OSCC, including 95 habitual BQ chewers and 101 non-BQ users, we conducted a quantitative survey of mutational signatures and genomic aberrations and explored their association with BQ chewing. Read More

J Clin Pathol 2020 May 29;73(5):273-277. Epub 2019 Oct 29.

Laboratório de Análises Clínicas, Centro Universitário Saúde ABC/Faculdade de Medicina do ABC, Santo Andre, Brazil

Aims: The aim of this study was to evaluate the mismatch repair gene expression and their correlation with in patients with oral squamous cell carcinoma (SCC).

Methods: Total RNA was isolated from 28 biopsy samples. A control group was composed of 20 volunteers. Read More

Int J Oncol 2019 Dec 7;55(6):1372-1384. Epub 2019 Oct 7.

Department of Oncology‑Pathology, Karolinska Institutet, 171 74 Stockholm, Sweden.

Fibroblast growth factor receptor (FGFR)3 and phosphatidylinositol‑4,5‑bisphosphate 3‑kinase, catalytic subunit alpha (PIK3CA) mutations are found in various types of cancer, such as urinary bladder cancer, human papillomavirus‑positive tonsillar and base of the tongue squamous cell carcinoma, breast cancer and some childhood sarcomas. Several drugs can target these genes, some of which have been used for the treatment of urinary bladder cancer. Much less is known about childhood cancer. Read More

Medicine (Baltimore) 2019 Sep;98(37):e17100

Department of Stomatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang.

Background: Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumors in head and neck, but its molecular mechanism is not clear.

Methods: Weighted gene co-expression network analysis (WGCNA) combining with gene differential expression analysis, survival analysis to screen key modules and hub genes related to the progress of TSCC. Gene Set Enrichment Analysis (GSEA) was used to identify biological pathways that might be involved. Read More

Ideggyogy Sz 2019 Jul;72(7-8):282-284

Koç University Hospital, Departments of Neurology, İstanbul, Turkey.

Introduction - Although the involvement of the hypoglossal nerve together with other cranial nerves is common in several pathological conditions of the brain, particularly the brainstem, isolated hypoglossal nerve palsy is a rare condition and a diagnostic challenge. Case presentation - The presented patient arrived to the hospital with a history of slurred speech and an uncomfortable sensation on his tongue. Neurological examination showed left-sided hemiatrophy of the tongue with fasciculations and deviation towards the left side during protrusion. Read More

Ann Surg Oncol 2019 Dec 9;26(13):4472-4480. Epub 2019 Sep 9.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.

Background: This study aimed to evaluate the feasibility and safety of the DaVinci SP system for performing transoral robotic surgery (TORS) in patients with head and neck cancer.

Methods: From October 2018 to April 2019, the medical records of 41 patients who underwent TORS using the DaVinci SP system were retrospectively reviewed.

Results: During TORS, three robotic arms could be used to perform a geometric resection of the lesion in a narrow working space. Read More

Int Wound J 2019 Dec 2;16(6):1433-1439. Epub 2019 Sep 2.

Nursing Development and Research Unit, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Canton Ticino, Switzerland.

One of the principal side effects in patients that receive radiotherapy is radiodermatitis. Radiodermatitis can be highly invalidating for patients, causing pain, ulceration, swelling, and increased infection risk, with a negative effect on the quality of life, requiring dressings and medications. Therapeutic approaches reported so far in the literature have not proved to be effective in treating radiodermatitis. Read More

Shanghai Kou Qiang Yi Xue 2019 Aprial;28(2):171-174

School of Stomatology , Qingdao University. Qingdao 266003, China.

Purpose: To compare the outcomes of using multiple kinds of sternocleidomastoid flap or free flaps to repair defects after oral cancer surgery.

Methods: Twenty-eight cases using sternocleidomastoid flaps and 30 cases using free flaps were included in this study. Operation was performed in 58 patients with oral cavity cancer. Read More

Microsurgery 2019 Oct 31;39(7):590-597. Epub 2019 Jul 31.

Otorhinolaryngology - Head and Neck Surgery, Humanitas Clinical and Research Hospital-IRCCS, Rozzano (MI), Italy.

Objectives: The antero-lateral thigh free flap (ALT) is conventionally designed as a fasciocutaneous flap (FALT). However, the thickness of the flap can be designed in at least in two more variants: myocutaneous (MYALT), and myofascial (MALT). The aim of this study was to evaluate the use of ALT flap as a universal solution for head and neck soft tissue reconstruction and development of an algorithm for flap selection in different clinical scenarios. Read More

Am J Case Rep 2019 Jul 21;20:1063-1070. Epub 2019 Jul 21.

Department of Pathology and Laboratory Medicine, Charleston Area Medical Center, Charleston, WV, USA.

BACKGROUND Radiation, specifically ionizing radiation, causes broad-spectrum gene damage, including double-strand DNA breaks, single DNA strand breaks, cross links, and individual base lesions, thus causing chromosomal translocations, deletions, point mutations, and, consequently, various types of cancer. Radiation also causes genomic instability in cells, which enhances the rate of mutations in the descendants of the irradiated cell after many generations of normal replications. CASE REPORT We report the first case of mantle cell lymphoma of the torus tubarius, and the first CD10-positive mantle cell lymphoma of the Waldeyer's ring. Read More

J Craniofac Surg 2019 Jul;30(5):e442-e446

Department of Oral and Maxillofacial Surgery, Chinese PLA General Hospital, Beijing, China.

Lingual thyroglossal duct cysts (LTDCs) are rare congenital anomalies of the neck. The authors described the presentation, management, and outcome of LTDC in pediatric and adult cases through a retrospective observational analysis between 2008 and 2018. Data included patients' demographics, main complaint, preoperative investigations, surgical management, and recurrences. Read More

Codas 2019 Jun 27;31(3):e20180100. Epub 2019 Jun 27.

Departamento de Fonoaudiologia, Faculdade de Odontologia de Bauru, Universidade de São Paulo - USP - Bauru (SP), Brasil.

The objective of this study was to verify the immediate effect of sensory and motor neuromuscular electrical stimulation (NMES), in the oral and pharyngeal phases of deglutition, in a 64 year male patient after laryngeal cancer treatment. Videofluoroscopy was performed during deglutition of 5 ml of honey and pudding, under three conditions: without stimulation, with sensory NMES, with motor NMES, randomly defined. The degree of dysfunction of deglutition (DOSS), the presence of food stasis (Eisenhuber scale), laryngeal penetration and laryngotracheal aspiration (PAS) and oral and pharyngeal transit time were evaluated. Read More

Ann Otol Rhinol Laryngol 2019 Nov 4;128(11):1041-1047. Epub 2019 Jul 4.

Department of Otolaryngology-Head and Neck Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.

Objective: To review the patient characteristics and outcomes for children and undergoing central neck dissection for control of recurrent thyroglossal duct cysts and fistula following prior Sistrunk procedures and children requiring surgery for refractory infection.

Methods: We performed a computerized review of all children who were evaluated for thyroglossal duct cysts during the years 1999-2018 by a single surgeon operating at an urban children's hospital and an outpatient surgical center. Those requiring a central neck dissection for control of recurrent disease or intractable infection were identified. Read More

Am J Otolaryngol 2019 Sep - Oct;40(5):673-677. Epub 2019 Jun 4.

Department of Radiation Medicine, College of Medicine, University of Kentucky, Lexington, KY, United States of America. Electronic address:

Purpose: Optimal treatment strategies for the management of oropharyngeal squamous cell carcinoma (OPSCC) remain unclear. The objective of this study is to examine the role of transoral robotic surgery (TORS) on functional and treatment outcomes.

Materials And Methods: A retrospective review of patients with OPSCC (tonsil/base of tongue) who underwent TORS with neck dissection± adjuvant therapy between January 2011 to December 2016 were compared to a stage matched cohort of patients treated with primary chemoradiation. Read More

Cancer Epidemiol 2019 08 31;61:89-94. Epub 2019 May 31.

Department of Biopathology, University Hospital of Montpellier, France.

Background: France has one of the highest incidence of head and neck cancers in Europe. Despite this, the epidemiological impact of high-risk human papilloma virus (HR-HPV) remains poorly investigated.

Methods: We prospective assessed the proportion of oropharyngeal cancers due to HR-HPV in 15 hospitals throughout France. Read More

Oral Oncol 2019 06 1;93:96-100. Epub 2019 May 1.

University of Toronto, Department of Otolaryngology - Head & Neck Surgery, Princess Margaret Cancer Center, 610 University Avenue, 3-955, Toronto, ON M5G 2M9, United States; Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada. Electronic address:

Background: Knowledge of the rate of occult contralateral nodal disease for oropharynx cancers (OPSCC) in the era of Human Papillomavirus-dominated disease would inform practitioners as to who may be a candidate for unilateral neck management. The objective of this study was to determine the rate of pathologic contralateral positive nodes in patients in OPSCC patients with pT1 and pT2 disease treated with TORS and bilateral neck dissections (BND).

Methods: Retrospective review of medical records was performed at Princess Margaret Cancer Center, Toronto; Icahn School of Medicine at Mount Sinai, New York City; and Montefiore Medical Center, New York City. Read More

Acta Otorhinolaryngol Ital 2019 04;39(2):75-83

Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Azienda USL della Romagna, Forlì, Italy.

Int J Cancer 2019 12 30;145(11):3152-3162. Epub 2019 May 30.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.

The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been increasing due to high-risk HPV infection. We explored the significance of genetic alterations in HPV-positive (HPV-P) and HPV-negative (HPV-N) OPSCC patients on long-term outcome. A total of 157 cases of primary resected OPSCC diagnosed from 1978 to 2005 were subjected to a targeted exome sequencing by MSK-IMPACT™ interrogating somatic mutations in 410 cancer-related genes. Read More

Anticancer Res 2019 May;39(5):2527-2533

Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany.

Background/aim: We evaluated survival rates in surgically-treated oral and oropharyngeal squamous cell carcinoma patients at our clinic, and determined whether survival differed by tumour locations.

Patients And Methods: In a retrospective study, tumour lesions in 1,486 patients were categorized into 6 groups according to tumour location. Patients' age, sex, tumour-node-metastasis classification, resection status, 5-year and disease-specific survival rates were statistically analysed between groups. Read More

Auris Nasus Larynx 2019 Oct 4;46(5):663-671. Epub 2019 May 4.

Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Azienda USL della Romagna, Forlì, Italy.

The identification of the site in head neck unknown primary (HNUP) tumour is of utmost importance to help select best treatment while decreasing treatment-related morbidity and mortality. The primary purpose of this study is to demonstrate that TORS may be a valuable tool in detecting primary tumour. Studies were systematically searched in the PubMed, EMBASE, the Cochrane Library and CENTRAL electronic databases. Read More

Int J Oral Maxillofac Surg 2019 09 28;48(9):1260-1261. Epub 2019 Apr 28.

Department of Pathology, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China. Electronic address:

Oral Oncol 2019 05 28;92:59-66. Epub 2019 Mar 28.

Bobby R. Alford Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, Houston, TX, United States. Electronic address:

Objective: Primary surgery followed by adjuvant therapy is the current standard of care in the multidisciplinary management of squamous cell carcinoma (SCC) of the oral tongue. Additionally, salvage glossectomy is used to treat recurrent base of tongue SCC. Microvascular free tissue transfer reconstruction (MVFTT) is utilized to maximize functional outcomes such as swallowing. Read More

Oral Oncol 2019 05 19;92:46-51. Epub 2019 Mar 19.

Nuclear Medicine Service, Department of Radiology, New Jersey Medical School, Rutgers University, Newark, NJ, USA. Electronic address:

Objective: The role of FDG PET/CT is uncertain in squamous cell carcinoma of unknown primary (SCCUP). Published data are limited by heterogeneity of pathology, varied diagnostic criteria, and small sample size.

Materials/methods: This retrospective study was conducted in 40 patients who had FDG PET/CT for SCCUP. Read More

Clin Ter 2019 Mar-Apr;170(2):e84-e85

Ospedale Pediatrico Bambin Gesù, reparto di Odontostomatologia, Roma, Italia.

Introduction: Human papillomaviruses cause almost all cervical carcinomas, but HPV infections have recently been established as a major etiologic factor for a subset of cancers arising from the oropharinx, including the base of tongue, tonsil, and other parts of the pharinx. Certain types of HPV are considered carcinogenic in humans: HPV 16 and HPV 18 are the most carcinogenic types; HPV 31, 33, 35,39,45,51,52,56,59,66 and 68 also are included in the group of carcinogenic HPV types (1,2,3,4,5). HPV 6 and 11 are associated with genital warts and papillomas are not believed to be carcinogenic (6). Read More

A A Pract 2019 Aug;13(3):91-92

From the Department of Anaesthesia and Acute Pain Medicine, St Vincent's Hospital, Melbourne, Victoria, Australia.

A patient with a base of tongue tumor was judged to be safe to intubate under general anesthesia, with a new flexible tip "bougie." This enabled rapid and easy navigation around the distorted anatomy caused by the tumor. The bougie's tip can be flexed or extended by activating a slide on the shaft and was intended for use with the hyperangulated blade of a videolaryngoscope. Read More

Clin Med Insights Oncol 2019 2;13:1179554919838254. Epub 2019 Apr 2.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of New Mexico Hospital, UNM School of Medicine, Albuquerque, NM, USA.

Background: Myoepithelial cell carcinoma is a rare malignant neoplasm of salivary gland origin that typically presents in the parotid gland and minor salivary glands. It has been described previously in head and neck sites such as buccal mucosa, alveolar ridge, and base of tongue.

Methods: A 55-year-old man presented with 30 years of right-sided tongue pain and 10 years of gradually worsening ulceration. Read More

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):7-11

Department of Oral and Maxillofacial Pathology and Microbiology, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.

Lymphomas are a group of malignant blood cell tumors that develop from lymphocytes representing 2.2% of all malignant neoplasms of the head and neck. Two main categories of lymphomas are Hodgkin's lymphoma and non-Hodgkin's lymphoma (NHL) of which 90% are of the NHL type. Read More

Anticancer Res 2019 Apr;39(4):1907-1914

Department of Internal Medicine, Division of Oncology-Hematology, VA Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, U.S.A.

Background/aim: HPV-mediated oropharyngeal squamous cell carcinoma is associated with an increased survival. The prognostic value of HPV status for other primary sites is unclear. We aimed to assess the effect of HPV status on overall survival in patients with non-oropharyngeal head and neck squamous cell carcinoma (non-OPSCC) using the National Cancer Database (NCDB). Read More

Acta Otorhinolaryngol Ital 2019 Feb;39(1):9-17

Department of Otolaryngology, University of Pavia and Foundation IRCCS Policlinico S. Matteo, Italy.

Oral Oncol 2019 04 6;91:97-106. Epub 2019 Mar 6.

Department of Otolaryngology, Head and Neck Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Institute of Head and Neck Studies and Education, University of Birmingham, UK; Institute of Cancer and Genomic Sciences, University of Birmingham, UK. Electronic address:

Background: The use of transoral robotic surgery (TORS) and laser microsurgery (TLM) in the diagnosis and identification of the site of the unknown primary has become increasingly common. This systematic review and meta-analysis aims to assess the use and efficacy of TORS and TLM for this indication.

Method: Systematic review and meta-analysis of studies employing TORS or TLM in diagnosis of the unknown primary tumor site in patients with cervical nodal metastases of squamous cell origin. Read More

J Contemp Brachytherapy 2019 Feb 28;11(1):28-34. Epub 2019 Feb 28.

Department of Radiation Oncology, Peking University Third Hospital, Beijing.

Purpose: The aim of this study was to evaluate the efficacy and safety of interstitial permanent low-dose-rate ultrasound-guided I seeds implantation of local head and neck recurrent tumors.

Material And Methods: Sixty-four consecutive patients, with 81 lesions in total, underwent permanent implantation of I seeds under ultrasound guidance. Post-operative dosimetry was performed for all patients. Read More

J Craniofac Surg 2019 Jun;30(4):e380-e382

Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung.

A thyroglossal duct cyst (TGDC) is a common embryological remnant that typically presents as an anterior neck mass; however, this malformation can occur in any adjacent area, including the tongue base (lingual type), along the migration path of the thyroid during embryonic development. Lingual TGDC is often quiescent until infection occurs. Supraglottitis or inflammation of the supraglottis, is a potentially life-threatening disease. Read More

Am Surg 2018 Aug;84(8):e290-e291

Clin Nucl Med 2019 May;44(5):e367-e369

From the Division of Nuclear Medicine, Department of Radiology and Biomedical Imaging.

We present a case of oropharyngeal squamous cell carcinoma (SCC) of the tongue base incidentally detected on F-fluciclovine PET/CT. A 79-year-old man with history of locally advanced prostate cancer (Gleason score 4 + 5 = 9; cT2cN1M0) previously treated with androgen deprivation therapy (luprolide + bicalutamide) presented with a slowly rising serum prostate-specific antigen over 3 years, concerning for recurrent disease. F-fluciclovine PET/CT, obtained to identify potential sites of recurrence, demonstrated prostate bed uptake with possible left seminal vesicle involvement. Read More

Acta Otolaryngol 2019 Feb 22;139(2):206-210. Epub 2019 Feb 22.

a Department of Oncology-Pathology , Karolinska Institute, CCK , Stockholm , Sweden.

Background: Human papillomavirus-positive (HPV) base of tongue squamous cell carcinoma (BOTSCC) has a better outcome than corresponding HPV cancer. TLR5 and TLR7 expression was previously shown to differ depending on HPV - status and correlate with outcome in oropharyngeal squamous cell carcinoma.

Aims/objectives: For validation, TLR5 and TLR7 were analyzed in a BOTSCC-cohort for correlation with HPV, survival, CD4 and CD8 tumor-infiltrating lymphocyte (TIL) counts, the latter being a well-documented prognostic marker. Read More