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Cureus 2022 May 16;14(5):e25057. Epub 2022 May 16.

Oral and Maxillofacial Pathology, Ragas Dental College and Hospitals, Chennai, IND.

Histological variants of oral squamous cell carcinoma (OSCC) include verrucous, basaloid, spindle cell, adenosquamous, papillary, and acantholytic types. Clear-cell changes in OSCC are rare. We report a case of a 65-year-old male Chinese patient who presented with a swelling in the lower-left mandible for three weeks, causing ill-fitting of his lower denture and an ulcer on the floor of the mouth. Read More

Zhonghua Bing Li Xue Za Zhi 2022 Jun;51(6):494-499

Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To investigate the clinical, histologic, immunohistochemical (IHC) and molecular genetic features of clear cell carcinoma (CCC) of salivary gland in the head and neck regions. Seven cases of CCC diagnosed in the Department of Pathology, the First Affiliated Hospital of Nanjing Medical University from 2018 to 2021 were included. The clinical and pathologic data, HE sections and IHC staining were reviewed, and EWSR1 gene translocation was detected by fluorescence in situ hybridization (FISH). Read More

Int J Surg Case Rep 2022 Jun 25;95:107239. Epub 2022 May 25.

Faculty of Medicine of Damscus University, Damascus, Syria; Al-Mouwasat University Hospital, Damascus, Syria.

Introduction: Rhabdomyomas are benign and rare mesenchymal tumors. They are classified into cardiac and extracardiac. However, the majority of adult subtype, which are extracardiac, tend to occur in the head and neck region. Read More

Oral Oncol 2022 Jul 11;130:105896. Epub 2022 May 11.

Department of Surgery, University Cancer Institute Toulouse - Oncopole, University Hospital of Toulouse, Toulouse, France. Electronic address:

Background: Salvage total glossectomy (TG) or total glosso-laryngectomy (TGL) remain controversial, as highly morbid procedures. The objective was to describe oncological and functional outcomes after salvage TG or TGL.

Methods: We performed a multicenter retrospective study, including patients with previous neck irradiation undergoing TG or TGL for squamous cell carcinoma involving the base of tongue. Read More

Ned Tijdschr Geneeskd 2022 03 10;166. Epub 2022 Mar 10.

Amsterdam UMC, Emma Kinderziekenhuis, Amsterdam: Afd. Radiologie en Nucleaire Geneeskunde.

An 8-year-old girl with a lingual thyroid was evaluated because of a tumor at the base of the tongue. Ultrasound showed a hypoechogenic homogeneous parenchymatous structure at the base of the tongue consistent with thyroid tissue. Suboptimal levothyroxine treatment resulted in longstanding TSH stimulation causing a lingual goiter. Read More

Oral Oncol 2022 Jun 28;129:105780. Epub 2022 Apr 28.

Department of Otolaryngology-Head and Neck Surgery, Augusta University, 1120 15(th) Street, Augusta, GA 30912, USA.

Neuroendocrine tumors are rare entities in the head and neck and an even more rare entity in the tongue. In this case report, we describe a calcified neuroendocrine tumor of the base of tongue that was presumed to be benign and was electively excised with pathology demonstrating low-grade carcinoma with focal neuroendocrine features and extensive ossification. We then discuss the histopathology and management. Read More

Oral Oncol 2022 05 16;128:105866. Epub 2022 Apr 16.

Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School & Hwasun Hospital, Hwasun, South Korea.

Introduction: Neoplasms of the tongue base are rare, but they range from benign neoplasms to congenital diseases and malignant neoplasms. The purpose of this study is to analyze the clinical features and recurrence factors of benign tumors of the tongue base.

Methods: The study included 27 cases of benign neoplasms of the tongue base from January 2010 to February 2022. Read More

Oral Oncol 2022 05 9;128:105832. Epub 2022 Apr 9.

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen 2100, Denmark; Department of Gynecology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen 2100, Denmark. Electronic address:

Objectives: Base-of-tongue (BOT)/tonsillar cancer incidence is rising, primarily due to human papillomavirus; meanwhile, rates of the mainly smoking-associated laryngeal cancer is declining. Little is known about whether these trends are seen in all socioeconomic levels and age-groups. We describe incidence trends of BOT/tonsillar and laryngeal cancer in Denmark 1994-2018 by educational level and age. Read More

J Clin Med 2022 Mar 31;11(7). Epub 2022 Mar 31.

Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.

Oral cavity and oropharynx cancer associated with human papil loma virus infection, particularly in young people who are continuously exposed to this virus, is a serious public health problem worldwide, especially for high-risk strains that are most associated with premalignant lesions and tumors. These neoplasms remain asymptomatic for a long time and, when they occur, they are already at an advanced stage. If diagnosed and treated early, oral cancer induced by human papilloma virus allows for high survival, as it often has a more favorable prognosis than oral cancers not directly related to viral infection. Read More

Dig Dis Sci 2022 05 8;67(5):1733-1738. Epub 2022 Apr 8.

Department of Surgical Sciences, Sapienza University, Rome, Italy.

Duodenal follicular lymphoma (DFL) is a rare variety of non-Hodgkin's lymphoma of the gastrointestinal tract that usually carries a favorable course, recognized as a new entity in 2016. It is usually diagnosed at an early stage located predominantly in the second portion of the duodenum. We report the case of a 74-year-old male patient with epigastric pain in whom gastroscopy revealed white mucosal nodules that were pathologically diagnosed as grade 1-2 DFL. Read More

Int J Surg Pathol 2022 May 12;30(3):282-287. Epub 2021 Aug 12.

8028Royal Cornwall Hospital, Truro, Cornwall, UK.

A 77-year-old male presented with a progressively enlarging midline neck mass. On further investigation he was found to have synchronous thyroglossal duct cyst and extranodal mantle cell lymphoma (MCL) localized to the base of tongue. Both pathologies were managed simultaneously with a surgical approach and the patient remained in clinical remission at the time of publication without indication for systemic oncological treatment. Read More

J Cancer Res Ther 2022 Jan-Mar;18(1):305-307

Department of Surgical Oncology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

With substantial improvement in survival in cancer patients, the risk of radiation-induced malignancy in previously irradiated areas is increasingly possible. Both radiation-induced sarcomas and papillary thyroid carcinomas (PTCs) are well documented in literature. However, radiation-induced synchronous malignancies are rare, are often misdiagnosed, and presents with diagnostic and therapeutic challenges due to paucity of literature and lack of available guidelines. Read More

Ann Otol Rhinol Laryngol 2022 Apr 2:34894221088175. Epub 2022 Apr 2.

Department of Otolaryngology - Head and Neck Surgery, St. Louis University Hospital, St. Louis, MO, USA.

Objectives: Lymphoma, categorized as either non-Hodgkin's lymphoma or Hodgkin's lymphoma, is the second most common malignancy in the head and neck. Primary tongue lymphoma is exceedingly rare, with only case reports or small case series in the literature. This population-based analysis is the first to report the epidemiology and prognostic factors of survival in patients with primary tongue lymphoma. Read More

Indian J Med Res 2021 Mar;154(3):497-503

Department of Imageology, Malabar Cancer Center, Thalassery, Kerala, India.

Background & Objectives: Human papillomavirus (HPV) and oropharyngeal squamous cell carcinoma (OPSCC) are found to be strongly associated with each other with an increase in incidence has been noted globally over the years. A literature search for data depicting the role of HPV in oropharyngeal carcinoma in South India, however, has resulted in little information, thus, the present study was aimed to assess a possible association between the two among OPSCC patients from a tertiary care cancer centre in South India.

Methods: One hundred and fourty three OPSCC cases were included in the study and analyzed for age, gender, marital status, habits, clinical TNM staging, site, laterality, symptoms, histological type (keratinizing and non-keratinizing), primary treatment and follow up period. Read More

Oncologist 2022 02;27(1):48-56

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Objectives: The eighth edition American Joint Committee on Cancer (AJCC) Staging incorporates significant changes to the seventh edition in the staging of oropharyngeal squamous cell carcinomas (OPSCC). An important change was the inclusion of OPSCC associated with the human papilloma virus (HPV). Our goal is to compare the performance of both staging systems for patients with HPV-selected and unselected clinical characteristics for OPSCC. Read More

Cancer Epidemiol 2022 Jun 15;78:102140. Epub 2022 Mar 15.

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong, China; Kirby Institute, The University of New South Wales, Sydney, NSW, Australia. Electronic address:

Background: Oropharynx is the anatomical site with the highest human papillomavirus (HPV) infection in head and neck. Many studies on HPV prevalence and p16 positivity in oropharyngeal cancer have been published in recent years. We aimed to update the global burden estimates of oropharyngeal cancer attributable to HPV with the latest data and estimate global burden of tonsillar cancer and base of tongue cancer attributable to HPV by region and country. Read More

Am J Otolaryngol 2022 May-Jun;43(3):103265. Epub 2021 Oct 14.

Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center Chicago, IL, USA. Electronic address:

Objectives: The purpose of this study was to investigate survival differences between low-grade and high-grade base of tongue (BOT) adenocarcinoma by examining demographics, tumor characteristics, and treatment modalities.

Methods: The National Cancer Database was queried for patients with BOT adenocarcinoma between 2004 and 2017. Univariate and multivariate analyses were performed for all cases of BOT adenocarcinoma. Read More

Med Sci Monit 2022 Mar 12;28:e935055. Epub 2022 Mar 12.

Heilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China (mainland).

BACKGROUND Tongue cancer is the most prevalent of head and neck squamous cell carcinomas, including base of tongue cancer (BOT) and oral squamous cell carcinoma of the mobile tongue (OTSCC). We aimed to investigate the role of RIPOR3 in tumorigenesis and its development as a potential prognostic biomarker for tongue cancer, especially OTSCC. MATERIAL AND METHODS Associations of expression, clinical pathologic features, and overall survival were analyzed by logistic regression, multivariate Cox analysis, and Kaplan-Meier methods. Read More

J Clin Sleep Med 2022 06;18(6):1681-1686

Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan.

Study Objectives: Head and neck squamous cell carcinoma (HNSCC) or its treatment may be associated with an increased risk of obstructive sleep apnea (OSA). However, reported relationships between OSA risk factors and HNSCC are inconsistent. This study examined associations between tumor variables and risk of OSA at least 1 year after completion of treatment for HNSCC. Read More

Gen Dent 2022 Mar-Apr;70(2):22-26

Healthcare professionals require effective treatment options for managing the complications that may arise during cancer treatment. The Multinational Association of Supportive Care in Cancer (MASCC) and the International Society of Oral Oncology (ISOO) work together to reduce oral complications secondary to cancer, including difficulties associated with oral mucositis (OM). The present article is intended to summarize the MASCC/ISOO guidelines, which are updated periodically based on the most recent evidence supporting the multiple treatment options for OM caused by chemotherapy and radiotherapy used to treat head and neck tumors. Read More

JNMA J Nepal Med Assoc 2021 Nov 15;59(243):1185-1188. Epub 2021 Nov 15.

Department of Emergency Medical Services, Government of Maldives, Ministry of Health Male, Maldives.

Laryngeal schwannomas are rare tumors of neural sheath origin. They normally present as a slow-growing, encapsulated, submucosal mass commonly in the supraglottic region. We describe a 13-year-old boy presenting with a 4-month history of progressive worsening dysphagia. Read More

Am J Surg Pathol 2022 Feb 24. Epub 2022 Feb 24.

Department of Pathology, Faculty of Medicine in Plzen, Charles University Bioptic Laboratory Ltd Molecular and Genetic Laboratory, Bioptic Laboratory Ltd, Plzen Department of Pathology, Tomas Bata Hospital, Zlin, Czech Republic Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU) Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen Departments of Pathology Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Solitary fibrous tumor (SFT) is a rare fibroblastic neoplasm with potentially malignant behavior that may develop in any anatomic site and may involve the head and neck (H&N) region as well. Although typical SFT has a relatively characteristic morphology, its morphologic spectrum is extraordinarily broad and also includes rare cases with dedifferentiation or transdifferentiation which result in aberrant morphologic and/or immunohistochemical features. However, since virtually all cases are molecularly characterized by NAB2::STAT6 gene fusions, molecular genetic methods or STAT6 immunohistochemistry can be effectively used in confirming the diagnosis. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Jul 20;134(1):e14-e22. Epub 2021 Oct 20.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China; Department of Pathology, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China. Electronic address:

A novel subset of epithelioid soft tissue tumors with GLI1 gene fusions or amplifications has recently been characterized. Histologically, these tumors typically exhibit multinodular or plexiform growth of ovoid, round to epithelioid neoplastic cells, with a distinctive nested architecture separated by a rich delicate arborizing vascular network. The immunoprofile is variable and nonspecific, indicating no definitive line of differentiation. Read More

Ann Clin Microbiol Antimicrob 2022 Feb 14;21(1). Epub 2022 Feb 14.

Department of Infectious Diseases, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Protothecosis is a rare infection in humans and animals caused by the achlorophyllic algae Prototheca species. More than half of the protothecosis cases are cutaneous infections, and most cases are observed in immunocompromised individuals.

Case Presentation: We report a case of Prototheca wickerhamii infection in the mucosa of the pharynx in a 53-year-old immunocompetent woman with an incidentally found mass lesion at the left tongue base. Read More

Am J Otolaryngol 2022 Mar-Apr;43(2):103386. Epub 2022 Feb 3.

Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, United States. Electronic address:

Objective: To perform a systematic review of studies reporting swallow-associated outcomes in patients who received surgery for head and neck cancer (HNC), informed by an anatomic and physiologic framework of pharyngeal phase of swallowing (Pearson's dual-sling model).

Methods: PUBMED and Google Scholar databases were searched for peer-reviewed papers published between 1990 and 2019 using relevant MeSH terms. Exclusion criteria were 1) discussions comparing reconstruction techniques, 2) case-report/series (n < 10), 3) perspective articles, 4) papers comparing objective instrumental methods of swallowing evaluation, 5) animal/cadaver studies, 6) no instrumental or validated swallow assessment tools used, 7) papers that discuss/include radiotherapy treatment, 8) systematic reviews, 9) papers that discuss swallow training or rehabilitation methods. Read More

Arch Oral Biol 2022 Mar 31;135:105359. Epub 2022 Jan 31.

Postgraduate Program in Dental Sciences, Oral Pathology and Medicine, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address:

Objective: To evaluate the oxidative DNA damage, through 8-hydroxy-2'-deoxyguanosine (8-OHdG), and its repair by base excision repair pathway [Redox factor-1 (Ref-1); X-ray Repair Cross Complementing-1 (XRCC-1)] in different epithelial dysplasia degrees in oral leukoplakia.

Design: Forty-four cases of oral leukoplakia and 10 normal oral mucosa were quantified for 8-OHdG, Ref-1, and XRCC-1 through immunohistochemistry.

Results: Cytoplasmic 8-OHdG and nuclear XRCC-1 were significantly associated with multiple synchronous lesions (p = 0. Read More

Radiother Oncol 2022 04 1;169:1-7. Epub 2022 Feb 1.

Department of Radiation Oncology, University Hospital Zürich, Switzerland. Electronic address:

Purpose/objective: Whereas the prevalence of lymph node level (LNL) involvement in head & neck squamous cell carcinomas (HNSCC) has been reported, the details of lymphatic progression patterns are insufficiently quantified. In this study, we investigate how the risk of metastases in each LNL depends on the involvement of upstream LNLs, T-category, HPV status and other risk factors.

Materials/methods: We retrospectively analyzed patients with newly diagnosed oropharyngeal squamous cell carcinoma (OPSCC) treated at a single institution, resulting in a dataset of 287 patients. Read More

Acta Oncol 2022 Apr 26;61(4):433-440. Epub 2022 Jan 26.

Oncology, Department of Clinical Sciences, Lund University and University Hospital of Scania, Lund, Sweden.

Background: The base of tongue squamous cell carcinoma (BOTSCC) is mainly an HPV-related tumor. Radiotherapy (EBRT) ± concomitant chemotherapy (CT) is the backbone of the curatively intended treatment, with brachytherapy (BT) boost as an option. With four different treatment strategies in Sweden, a retrospective study based on the population-based Swedish Head and Neck Cancer Register (SweHNCR) was initiated. Read More

Acta Oncol 2022 Feb 21;61(2):146-152. Epub 2022 Jan 21.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: To analyze the influence of radiation dose on late radiation-associated taste impairment in oropharyngeal cancer (OPC) patients treated with intensity-modulated radiotherapy (IMRT) using the taste bud bearing tongue mucosa as organ at risk.

Material And Methods: This study is part of an ongoing, prospective observational study. Cancer-free OPC survivors with at least 24 months from IMRT were included in this analysis. Read More

Gen Dent 2022 Jan-Feb;70(1):61-64

This article presents a case of an epidermoid cyst that mimicked a thyroglossal duct cyst in a pediatric patient. An 8-year-old boy was referred for evaluation of a volumetric increase in the median cervical region with an evolution of about 4 years. The skin in the submental region was healthy and normal colored. Read More