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Cancer Res 2019 Jan 18. Epub 2019 Jan 18.

Department of Oral & Maxillofacial Surgery, No. 2 Affiliated Hospital,Sun-Yat-Sen University.

MicroRNAs (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNAs (mitomiR). mitomiR have been shown to modulate the translational activity of the mitochondrial genome, yet their role in mitochondrial DNA(mtDNA) transcription remains to be determined. Here we report that the mitomiR-2392 regulates chemoresistance in tongue squamous cell carcinoma (TSCC) cells by reprogramming metabolism via downregulation of oxidative phosphorylation (OXPHOS) and upregulation of glycolysis. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1804-1809

Department of Otorhinolaryngology, the First Affiliated Hospital, Bengbu Medical College, Bengbu, 233004, China.

To find proper the surgical approval and evaluate clinical efficacy to treat the tumor of upper parapharyngeal space involving the base of skull and intracranial skull. The data of 9 cases from June 2013 and June 2018 were analyzed retrospectively including schwannoma in 6 cases, pleomorphic adenoma in 2 cases and hemangioma in 1 case. All cases received preoperative high resolution CT and MRI, some cases also did the DSA examination. Read More

Braz Oral Res 2018 Dec 6;32:e123. Epub 2018 Dec 6.

Hospital General de México "Eduardo Liceaga", Department of Pathology, México City, México.

This study aims to evaluate the clinicopathological features, TNM status, AJCC staging and behavior of squamous cell carcinoma of the tongue (SCCT) in patients older than 45 years. The files of the Department of Pathology of the Hospital General de México were reviewed and all cases of SCCT in patients older than 45 years were selected. Clinicopathological features, treatment, follow-up, microscopic diagnosis, and IJCC and TNM staging were retrieved. Read More

Int J Surg Case Rep 2019 30;54:70-74. Epub 2018 Nov 30.

Department of Otorhinolaryngology and Head and Neck Surgery, San Fernando Teaching Hospital, Trinidad and Tobago; Department of Clinical Surgical Science, University of the West Indies, St. Augustine, Trinidad and Tobago.

Background: Lymphomas are malignant neoplasms of the lymphocyte cell lines affecting the lymph nodes, spleen and other nonhemopoietic tissues. Of the extranodal lymphomas found in the head and neck region, 3-5% of malignant lymphomas arise in the oral and paraoral region, mainly from Waldeyer's ring. The involvement of the base of the tongue is extremely rare. Read More

J Laryngol Otol 2018 Dec 20;132(12):1138-1142. Epub 2018 Nov 20.

Department of ENT, Head and Neck Surgery,Royal Sussex County Hospital,Brighton, and Head and Neck Unit,Queen Victoria Hospital,East Grinstead,UK.

Background: Cervical metastasis from an unknown primary site invariably results in pan-mucosal irradiation if a primary tumour is not identified. Transoral robotic and laser-assisted mucosectomy are valid techniques to increase diagnostic rates, but these remain restricted to certain centres. This paper describes, in detail, a technique in which mucosectomy is performed via endoscopic electrocautery. Read More

Clin Nucl Med 2019 Feb;44(2):e110-e112

Departments of Radiology and Imaging.

A 53-year-old man with T4aN2cM0 tongue base squamous cell carcinoma received definitive chemoradiation. FDG PET/CT at 6 weeks showed partial metabolic response with soft tissue air indicating radiation necrosis at primary site and complete response in the neck. At 9 weeks, contrasted CT showed worsening but nonenhancing ulceration, area biopsied demonstrating a minute carcinoma focus with treatment effect. Read More

BMJ Case Rep 2018 Oct 14;2018. Epub 2018 Oct 14.

Department of ENT, Royal United Hospitals Bath NHS Foundation Trust, UK.

An 80-year-old woman presented with dysphagia, odynophagia and progressive weight loss. Initial investigations suggested a large base of tongue squamous cell carcinoma. At panendoscopy, biopsies were taken which revealed granulomatous inflammation with multinucleated giant cells and areas of caseous necrosis. Read More

World J Surg Oncol 2018 Oct 10;16(1):201. Epub 2018 Oct 10.

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Background: Glomus tumors are rare benign neoplasms that usually occur in the upper and lower extremities. Oral cavity involvement is exceptionally rare, with only a few cases reported to date.

Case Presentation: A 24-year-old woman with complaints of swelling in the left floor of her mouth for 6 months was referred to our institution. Read More

Dysphagia 2018 Sep 28. Epub 2018 Sep 28.

Department of Radiation Oncology, Olivia Newton John Cancer Wellness & Research Centre, Austin Health, Heidelberg, VIC, Australia.

The purpose of this study was to investigate whether the metabolic tumor volume (MTV) of head and neck primary tumors may be a significant prognostic factor for feeding tube (FT) use and FT dependence. Seventy-nine patients with evaluable primary tumors, pre-therapy FDG-PET scans, treated with definitive intensity-modulated radiotherapy (IMRT) (± concurrent chemotherapy) for head and neck mucosal cancers were included. MTV was quantified and recorded for the primary lesion using a minimum standardized uptake value (SUV) threshold of 2. Read More

J Robot Surg 2018 Aug 20. Epub 2018 Aug 20.

Department of Otolaryngology, Head and Neck surgery, The Royal Adelaide Hospital, Port Road, Adelaide, SA, 5000, Australia.

Transoral robotic surgery (TORS) provides improved access to head and neck subsites resulting in well-validated functional and oncological outcomes, but access to and cost of robotic platforms can limit their use. Evidence suggests TORS is increasingly being adopted globally, but there is a paucity of data on the adoption and diffusion of TORS in Australia and New Zealand. A cross-sectional analysis was performed. Read More

Med Phys 2018 Oct 19;45(10):4329-4344. Epub 2018 Sep 19.

Department of Medical Physics, Faculty of Medicine and Health, Örebro University, 70182, Örebro, Sweden.

Purpose: To evaluate two commercial CT metal artifact reduction (MAR) algorithms for use in proton treatment planning in the head and neck (H&N) area.

Methods: An anthropomorphic head phantom with removable metallic implants (dental fillings or neck implant) was CT-scanned to evaluate the O-MAR (Philips) and the iMAR (Siemens) algorithms. Reference images were acquired without any metallic implants in place. Read More

Anticancer Res 2018 Aug;38(8):4683-4690

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

Background/aim: Human papillomavirus-positive (HPV) tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) have better outcome than corresponding HPV cancers. To better individualize treatment, additional predictive markers are needed. Previously, we have shown that mutated fibroblast growth factor receptor 3 protein (FGFR3) was correlated to poorer prognosis and here FGFR3 expression was further analyzed. Read More

Am J Surg Pathol 2018 Sep;42(9):1182-1189

Department of Pathology and Laboratory Medicine, University of British Columbia.

We describe a novel gene fusion, EWSR1-CREM, identified in 3 cases of clear cell carcinoma (CCC) using anchored multiplex polymerase chain reaction, a next-generation sequencing-based technique. CCC is a low-grade salivary tumor recently characterized to have EWSR1-ATF1 fusions in the majority of cases. Three cases of malignant tumor presenting in the base of tongue, lung, and nasopharynx were studied. Read More

BMJ Case Rep 2018 Jul 3;2018. Epub 2018 Jul 3.

Department of Pathology, AIIMS, Bhubaneswar, Odisha, India.

Head and neck paraganglioma is a rare disease to encounter in clinical practice and involvement of the base of the tongue in the oropharynx is yet to be described in the current literature. Although various surgical approaches have been described in the literature, transcervical mandibular swing is an effective technique for adequate exposure and complete excision of the oropharyngeal paraganglioma with adequate control on bleeding especially when it is assisted by coblation. Read More

Cell Mol Biol Lett 2018 18;23:28. Epub 2018 Jun 18.

Oral and Maxillofacial Surgery, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, Hebei 061000 People's Republic of China.

Background: It has been reported that the expression of activating transcription factor 3 (ATF3) is closely associated with both microRNA (miRNA) processing and the progress of many cancers. Our study aimed to explore the interaction between ATF3 and miR-488 in tongue squamous cell carcinoma (TSCC).

Methods: Quantitative real-time PCR was performed to detect the levels of ATF3 and miR-488 in TSCC tissues and cell lines. Read More

Rom J Morphol Embryol 2018 ;59(1):113-119

Department of Preclinical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, Romania; Department of Ophthalmology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Introduction: Anterior wall of the oropharynx or the base of the tongue is the site of different types of cancers, most of them usually diagnosed in advanced stages. The most common histological type of cancer diagnosed in these patients is squamous cell carcinoma (SCC). The treatment methods are multiple, but the optimal therapeutic option with best results on outcome and on the patients' quality life has not been established. Read More

ORL J Otorhinolaryngol Relat Spec 2018 20;80(3-4):117-124. Epub 2018 Jun 20.

Department of Otorhinolaryngology and Head and Neck Surgery, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.

The first application of robotic technology in surgery was described in 1985 when a robot was used to define the trajectory for a stereotactic brain biopsy. Following its successful application in a variety of surgical operations, the da Vinci® robot, the most widely used surgical robot at present, made its clinical debut in otorhinolaryngology and head and neck surgery in 2005 when the first transoral robotic surgery (TORS) resections of base of tongue neoplasms were reported. Subsequently, the indications for TORS rapidly expanded, and they now include tumours of the oropharynx, hypopharynx, parapharyngeal space, and supraglottic larynx, as well as obstructive sleep apnoea (OSA). Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jun;53(6):428-431

Department of Head and Neck Surgery, National Cancer Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Cancer Hospital, Beijing 100021, China.

To explore whether early oral feeding after total laryngectomy is safe and effective by evaluating the incidence of pharyngocutaneous fistula (PCF) and the hospital duration. A retrospective cohort study was conducted, including 52 patients underwent total laryngectomy, plus partial tongue base resection (=2), partial pharyngectomy (=1), or pedicle flap (=2) between January 2012 and October 2017. Patients who had a history of preoperative radiotherapy, chemotherapy or chemoradiotherapy, previous surgery for larynx or pharynx and who had severe complications were excluded. Read More

Mol Med Rep 2018 Aug 5;18(2):1616-1622. Epub 2018 Jun 5.

Second Department of Orthopaedic Surgery, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China.

Long noncoding RNA AFAP1‑AS1 has been shown to promote tumor progression in several human cancer types, such as thyroid cancer, tongue squamous cell carcinoma and lung cancer. However, the role of AFAP1‑AS1 in osteosarcoma (OS) has not been investigated. In the present study, the expression of AFAP1‑AS1 was significantly upregulated in OS tissues and cell lines. Read More

Pain Physician 2018 05;21(3):295-302

Department of Otolaryngology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: The management of glossopharyngeal neuralgia due to oropharyngeal carcinoma is particularly difficult because of rich innervations of the area, erosive nature of neoplasm and dynamic pain evoked by the functional movements like swallowing and chewing. Few case reports have shown the efficacy of pulsed radiofrequency (PRF) treatment in primary and secondary glossopharyngeal neuralgia in non-cancer patients. However, the efficacy of PRF ablation of the glossopharyngeal nerve in oral cancer patients is not known. Read More

JAAPA 2018 Jun;31(6):30-33

Megan L. Adelman practices at the Ohio State University's Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, in Columbus, Ohio. Quoc-Anh Ho is a medical student at the University of California at Davis in Sacramento, Calif. Amit Agrawal is an associate professor in the Department of Otolaryngology at the Ohio State University Hospital in Columbus. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Bazex syndrome (acrokeratosis paraneoplastica) is an uncommon dermatologic condition associated with an underlying malignancy, most commonly squamous cell carcinomas of the head and neck. This article describes Bazex syndrome in a 56-year-old woman who presented with bilateral cervical lymphadenopathy and a mass at the base of her tongue. Read More

J Craniomaxillofac Surg 2018 Aug 24;46(8):1303-1312. Epub 2018 May 24.

Division of Epidemiology (DEPI), Office of Surveillance & Biometrics (OSB), Center for Devices and Radiological Health (CDRH), U.S. Food & Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.

The purpose of this cross-sectional study is to examine the relationship between surgical treatments for sleep-disordered breathing (SDB) and composite measure of surgical complications in a nationally representative sample of hospital discharges among U.S. adults. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Dec;31(24):1867-1872

Department of Head and Neck Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College.

To summarize the clinicopathological characteristics and prognostic factors of squamous cell carcinoma (SCC) of the base of tongue (BOT). Review the clinical data of 124 cases of patients with BOT tumors. HPV-DNA was detected using SPF10-DNA enzyme immunoassay and LiPA genotyping method. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Nov;31(22):1705-1710

Department of Otorhinolaryngology Head and Neck Surgery, Peking University First Hospital, Beijing, 100034, China.

To evaluate the feasibility and effectiveness of coblation assisted transoral surgery for the treatment of oral and oropharyngeal malignancy. 19 patients who suffered from oral or oropharyngeal malignant tumors underwent coblation assisted transoral surgery from August 2008 to August 2017 were studied. According to the tumor sites and pathological results, there were four oral squamous cell carcinoma (SCC) (two tongue carcinoma and two mouth floor carcinoma), eleven oropharygneal SCC (five tonsillar carcinoma, four soft palate carcinoma, one tongue base cartinama and one multiple carcinoma invading both soft palatine and hypopharynx), and four lymphatic and hematopoietic malignancies (three tonsillar tumors and one tumor invading both tonsil and tongue base). Read More

Acta Otolaryngol 2018 Sep 15;138(9):855-858. Epub 2018 May 15.

b Department of Clinical Science, Intervention and Technology, Otorhinolaryngology Head and Neck Surgery , Karolinska University Hospital , Stockholm , Sweden.

Background: Distinguishing branchial cleft cysts (BCCs) from cystic metastases of a human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) is challenging. Fine needle aspirates (FNAs) from cystic metastasis may be non-representative, while reactive squamous cells from BCC can be atypic. Based on cytology and with the support of HPV DNA positivity many centers treat cystic metastasis oncological and thus patients are spared neck dissection. Read More

Arch Oral Biol 2018 Aug 30;92:32-37. Epub 2018 Apr 30.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China. Electronic address:

Purpose: This study evaluated the role of anti-tumor immune response of curcumin on tongue squamous cell carcinama (TSCC).

Experimental Design: Cell lines (Cal 27, FaDu) and animal model (4NQO mice model) were uesd in this study. The MTT assay was used to detecte cell proliferation. Read More

J Otolaryngol Head Neck Surg 2018 May 9;47(1):32. Epub 2018 May 9.

Division of Medical Oncology, Department of Medicine, Dalhousie University, QEII - Bethune Building, Suite 470 Bethune Building, 1276 South Park Street, Halifax, B3H 2Y9, NS, Canada.

Background: HPV-associated OSCC (HPV-OSCC) has been determined to be a distinct disease entity from non-HPV associated OSCC. Patients affected by HPV-OSCC generally have a more favourable prognosis, with improved rates of locoregional control and survival compared with their non-HPV counterparts. Despite this, HPV-OSCC has a similar rate of distant metastases. Read More

J Oral Maxillofac Pathol 2018 Jan-Apr;22(1):108-111

Department of Oral Pathology and Microbiology, Subharti Dental College, Meerut, Uttar Pradesh, India.

Basaloid squamous cell carcinoma is a rare distinct histologic variant of squamous cell carcinoma of the head and neck region. Majority of them can be differentiated from squamous cell carcinoma by their aggressive clinical course and their histological features: the usual site of occurrence of basaloid squamous cell carcinoma is the upper areodigestive tract, floor of mouth and base of tongue. We hereby present two cases of a rare but aggressive basaloid squamous cell carcinoma, both affecting mandible. Read More

J Otolaryngol Head Neck Surg 2018 Apr 24;47(1):27. Epub 2018 Apr 24.

Division of Otolaryngology-Head and Neck Surgery, University of Alberta, 1E4 Walter Mackenzie Center, 8440 112 Street, Edmonton, AB, T6G 2B7, Canada.

Background: Defects following resection of tumors in the head and neck region are complex; more detailed and defect-specific reconstruction would likely result in better functional and cosmetic outcomes. The objectives of our study were: 1) to improve the understanding of the two- and three-dimensional nature of oral cavity and oropharyngeal defects following oncological resection and 2) to assess the geometric dimensions and the shapes of fasciocutaneous free flaps and locoregional tissue flaps required for reconstruction of these defects.

Methods: This study was an anatomic cadaveric study which involved creating defects in the oral cavity and oropharynx in two cadaveric specimens. Read More

Med Oral Patol Oral Cir Bucal 2018 May 1;23(3):e295-e301. Epub 2018 May 1.

Clinical and Social Dentistry Department, Health Sciences Center, Federal University of Paraiba, Campus I, Cidade Universitária. João Pessoa-PB, ZIP code: 58051-900,

Background: To evaluate the prevalence of oral cancer in Brazil according to the clinical stage, anatomical location, alcoholism and smoking.

Material And Methods: Data referring to 31,217 cases of oral cancer, from 2000 to 2010, were obtained from the Integrator Module of the Hospital Registry of Cancer. Inconsistent data ("non-classified" cases) was eliminated and 21,160 cases were analyzed. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Mar;53(3):214-218

Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To evaluate the quality of life (QOL) of patients who underwent resection of tongue base cancer and reconstruction by anterolateral thigh perforator free flap(ALTFF). A total of 77 patients with tongue cancer who underwent glossectomy and reconstruction by ALTFF were retrospectively analyzed in this work. At intervals of 3-month before operation, as well as both 3-month and 12-month post-operation, the QOL of these patients was assessed by using the 14-item Oral Health Impact Profile questionnaires(OHIP-14) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Module(EORTC-QLQ-H&N35). Read More

Eur Arch Otorhinolaryngol 2018 Jun 2;275(6):1601-1606. Epub 2018 Apr 2.

Department of Otorhinolaryngology-Head and Neck Surgery, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Shanghai, 200433, China.

Purpose: Surgical preservation of laryngeal function is very challenging in patients with advanced SCCL, especially those of stage T4a. The purpose of this study was to assess the feasibility of organ preservation surgery for patients with T4a squamous cell carcinoma of the larynx (SCCL).

Methods: We enrolled 32 patients with T4a SCCL and performed organ preservation surgery on them. Read More

J Registry Manag 2017 ;44(1):4-10

BACKGROUND: Age-standardized incidence rates (ASIRs) for US non-Hispanic whites (NHWs) have been increasing since 1999 for squamous cell carcinomas (SCC) at oropharyngeal (OP) anatomic sites strongly associated with human papillomavirus (HPV), as also reported from certain European countries. ASIRs declined slightly, however, from 2000–2006 to 2007–2012 in Stockholm County, Sweden (an urban area) for SCC of the tonsil (TSCC) but not base of tongue (BTSCC). For the United States, this study examined the growth of the epidemic of these cancers in 1992–2013. Read More

Int J Mol Sci 2018 Mar 25;19(4). Epub 2018 Mar 25.

Department of Clinical Science and Technology (CLINTEC), Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden.

Human papillomavirus (HPV) is a major etiological factor for tonsillar and the base of tongue cancer (TSCC/BOTSCC). HPV-positive and HPV-negative TSCC/BOTSCC present major differences in mutations, mRNA expression and clinical outcome. Earlier protein studies on TSCC/BOTSCC have mainly analyzed individual proteins. Read More

Dysphagia 2018 10 23;33(5):691-706. Epub 2018 Mar 23.

First Department of Oto-rhino-laryngology, Aristotle University of Thessaloniki School of Medicine, AHEPA University Hospital, St. Kiriakidi 1, 54636, Thessaloníki, Greece.

The aim of this study was to investigate the prevalence, severity, and pattern of evolution of swallowing impairments encountered in head and neck cancer (HNC) patients before and after chemoradiation (CRT) with videofluoroscopy of swallowing study (VFSS), using the modified barium swallow impairment profile (MBSImP) protocol and scoring system, and to determine the appropriate time points in which these patients should undergo VFSS post-CRT. A prospective cohort of 69 patients with locally advanced HNC underwent VFSS with the MBSImP protocol at 5 evaluation points: pre-CRT, and 1, 3, 6, and 12 months post-CRT. VFSS was scored with MBSImP, penetration-aspiration scale (PAS), and swallowing performance status (SPS) scale. Read More

J Craniofac Surg 2018 Jul;29(5):1300-1304

State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.

Flaps-based microsurgery is routinely applied to reconstruct oral floor defects caused by oncologic resection. To prevent orocutaneous fistulae, flaps are frequently sutured with buccal vestibule mucosa after sacrificing the alveolar process. The patients suffered denture loss and irreversible structural damage. Read More

Rev Esp Anestesiol Reanim 2018 May 2;65(5):252-257. Epub 2018 Mar 2.

Servicio de Anestesiología y Reanimación, Hospital Clínico San Carlos, Madrid, España.

Objectives: To establish a correlation between 4 measurements made on preoperative computed axial tomography and the presence of difficult airway, as well as its clinical prediction in patients undergoing otorhinolaryngological surgery.

Material And Methods: A retrospective, observational study was carried out using the information gathered from the clinical notes of 104 patients undergoing general anaesthesia and endotracheal intubation for oncological otorhinolaryngological surgery over a period of 36 months. Based on the findings in the preoperative imaging tests, a multivariate logistic regression analysis was performed, where the dependent variable was the presence of extreme grades of visualization of the glottis visualisation (Cormack III-IV) or the presence of predictors of difficult intubation (Mallampati III-IV). Read More

Laryngoscope 2018 09 26;128(9):2076-2083. Epub 2018 Feb 26.

University of Melbourne, Parkville, Victoria, Australia.

Objectives/hypothesis: The outcomes of unilateral radiotherapy treatment for patients with p16/HPV-positive squamous cell carcinomas of unknown primary (SCCUP) affecting cervical lymph nodes are under-reported. Compared to radiating large volumes of the pharyngeal axis (the more common approach), this is potentially a much less toxic treatment for a good prognosis group.

Study Design: Retrospective cohort study. Read More

Int J Oral Maxillofac Surg 2018 Jul 13;47(7):846-853. Epub 2018 Feb 13.

Department of Otolaryngology-Head and Neck Surgery, Hallym University Medical Centre, Seoul, Republic of Korea. Electronic address:

The aim of this study was to determine whether base of tongue (BOT) cancer is tongue cancer located at the base of the tongue or lingual tonsil cancer originating from tonsil tissue. This was a retrospective study using data from The Cancer Genome Atlas (TCGA). The genomic patterns of three primary cancers (BOT, oral tongue, and tonsil) were compared to determine their similarities and differences. Read More

Pathologica 2017 Dec;109(4):384-388

Pathology Unit, ASST Valle Olona, Busto Arsizio, Italy.

Malignancies of the parotid gland are relatively uncommon, accounting for only 3-6% of all head and neck cancers. Most of them are primary neoplasms, metastases are uncommon. Renal cell carcinoma (RCC) represents 3% of adult malignancies, the clear cell type comprises up to 70% of all RCC. Read More

J Surg Oncol 2018 Apr 12;117(5):1092-1099. Epub 2018 Feb 12.

Maxillo-Facial Surgery Unit, AOU-Careggi, Florence, Italy.

Background And Objectives: Reconstruction of tongue cancer defects is challenging due to the complex anatomy and physiology of the tongue. Here, we classify patterns of tongue tissue loss and describe a treatment algorithm for achieving good functional and oncologic outcomes.

Methods: We retrospectively reviewed 50 tongue squamous-cell carcinomas surgically treated between January 2010-June 2015. Read More

Laryngoscope 2018 09 2;128(9):2060-2066. Epub 2018 Feb 2.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Genoa, Genoa, Italy.

Objectives/hypothesis: There is no general consensus on what kind of examination to include in an optimal detection strategy for head and neck squamous cell carcinomas of unknown primary (SCCUPs). This study investigates the role of narrow-band imaging (NBI) in their identification.

Study Design: Case series. Read More

Sci Rep 2018 01 25;8(1):1567. Epub 2018 Jan 25.

Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Laboratory of Molecular Virology and Cell Biology, Indian Institute of Technology-Madras, Chennai, 600 036, India.

Oral malignancies remain to have higher morbidity and mortality rates owing to the poor understanding of the carcinogenesis and the lack of early detection and diagnosis. The lack of established biomarkers for oral tongue squamous cell carcinoma (OTSCC) resulted in aggressive multi-modality management less effective. Here, we report for the first time that a panel of potential markers identified from tongue tumor samples using two-dimensional-differential-in-gel-electrophoresis (2D-DIGE). Read More

J Vet Med Sci 2018 Mar 25;80(3):488-491. Epub 2018 Jan 25.

Laboratory of Veterinary Pathology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

A mass was found at the base of the dorsum linguae of a male 11-year-old Labrador retriever. The tumor comprised of ganglion cells and Schwannian cells with Verocay bodies. The ganglion cells were positive for neuron-specific enolase, S-100, nerve growth factor receptor, and beta III tubulin. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jan;53(1):45-48

Department of Otorhinolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing 100191, China.

To explore the possibility of endoscope assisted curved laryngoscopy technique applied in transoral laryngopharyngeal minimally invasive surgery and evaluate the advantages of this technique. Eight patients with huge benign lesions in larynx and pharynx undergoing transoral microsurgery at Peking University Third Hospital between February 2016 and February 2017 were enrolled in this study.The diagnosis included cyst at the base of tongue in two patients, cysts in the epiglottis in two patients, hemangioma in two patients, multiple masses of the hypopharynx and amyloidosis in supraglottic area in one patient each. Read More

Oral Oncol 2018 Feb 4;77:105-110. Epub 2018 Jan 4.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States. Electronic address:

Objective: To examine reader performance in evaluating oropharyngeal anatomy on ultrasonography.

Materials And Methods: Ultrasound images of the oropharynx comprising normal and malignant anatomic variants were organized into slideshows. Slideshows were administered to 6 readers blinded to participant tumor status and with varying experience reading oropharyngeal sonograms. Read More

Semin Cancer Biol 2018 10 31;52(Pt 2):228-240. Epub 2018 Jan 31.

Department of Medical Oncology, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3052, Australia.

Head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous group of tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and hypopharynx. While many HNSCCs are related to classical etiologic factors of smoking and alcohol, a clinically, genomically, and immunologically distinct subgroup of tumors arise from the epithelium of the tonsil and the base of tongue as a result of infection with Human Papilloma Virus (HPV). In this review we describe the genomic and immunologic landscape of HNSCC, highlighting differences between HPV-positive and HPV-negative HNSCC. Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Jun 12;135(3):197-199. Epub 2018 Jan 12.

Otolaryngology-Head and Neck Surgery Department CS 10217, Grenoble Alpes University Hospital, 38043 Grenoble cedex 9, France; Grenoble Alpes University, School of Medicine, Grenoble, France; UGA/UMR/CNRS 5309/Inserm 1209, Albert-Bonniot Institute, Grenoble, France; Division of Otolaryngology, Department of Surgery, University of Alabama, Birmingham, AL, USA. Electronic address:

The main advantage of endoscopic laser surgery for laryngeal cancer is to allow tumour resection, while limiting functional sequelae, thereby improving the postoperative course. In this type of surgery, the epiglottis is often partially resected, leaving a raw zone without any reconstruction. The surgical technique described here involves endoscopic reconstruction of the epiglottis after partial resection. Read More

Cancer Res Treat 2018 Oct 26;50(4):1214-1225. Epub 2017 Dec 26.

Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.

Purpose: The purpose of this study was to compare the clinical and functional outcomes in patients with primary base of tongue (BOT) cancer who received definitive radiotherapy (RT) or surgery followed by radiotherapy (SRT).

Materials And Methods: Between January 2002 andDecember 2016, 102 patientswith stage I-IVB primary BOT cancer underwent either definitive RT (n=46) or SRT (n=56), and treatment outcomeswere compared between two groups. The expression of p16 was also analyzed. Read More

Laryngoscope 2018 08 27;128(8):1783-1790. Epub 2017 Dec 27.

Department of Otolaryngology-Head and Neck Surgery, New York University Voice Center, New York University School of Medicine, New York, New York.

Objectives/hypothesis: To develop a clinically relevant model of oropharyngeal concurrent chemoradiation therapy (CCRT) in order to quantify the effects of CCRT on tongue function and structure. CCRT for advanced oropharyngeal cancer commonly leads to tongue base dysfunction and dysphagia. However, no preclinical models currently exist to study the pathophysiology of CCRT-related morbidity, thereby inhibiting the development of targeted therapeutics. Read More