3,551 results match your criteria Malignant Testicular Tumor Imaging


Multiparametric ultrasound for the assessment of testicular lesions with negative tumoral markers.

Asian J Androl 2022 Jun 10. Epub 2022 Jun 10.

Department of Ultrasound, Zhongshan Hospital, Fudan University, Institute of Ultrasound in Medicine and Engineering, Shanghai 200032, China.

The purpose of this study was to evaluate the diagnostic performance of multiparametric ultrasound (mpUS; grayscale US, color Doppler US, strain elastography, and contrast-enhanced US) in the assessment of testicular lesions with negative tumoral markers. MpUS imaging data, patient age, serum tumor markers, scrotal pain, cryptorchidism, and related clinical information were retrospectively collected for patients who underwent mpUS examination between January 2013 and December 2019. Histologic results or follow-up examinations were used as the reference standard. Read More

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Poorly Differentiated Neuroendocrine Carcinoma of Unknown Primary with Metastasis to the Testis: A Case Report.

Case Rep Oncol 2022 Jan-Apr;15(1):388-393. Epub 2022 Apr 8.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Neuroendocrine neoplasms are rare epithelial neoplasms with neuroendocrine differentiation. Few cases of primary testicular poorly differentiated neuroendocrine carcinomas (PD-NECs) have been reported, and secondary testicular neoplasms are rare. A 61-year-old man with a chief complaint of left testicular swelling was referred to our hospital. Read More

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Symptomatic burned-out testicular seminoma: A case report.

Int J Surg Case Rep 2022 Jun 26;95:107245. Epub 2022 May 26.

Dept. of Surgery, "Vito Fazzi" Hospital, Piazza Filippo Muratore, 73100 Lecce, Italy. Electronic address:

Introduction And Importance: Burned-out testicular cancer is a rare phenomenon to be taken into account for differential diagnosis in males presenting with retroperitoneal lymphadenopathy.

Case Presentation: A 54-years-old male complaining of abdominal pain over the past several months was found on CT to have a large mass adjacent to the inferior vena cava, with the imaging features of a malignant lymphadenopathy.

Clinical Discussion: The hematologist who evaluated the case suggested a biopsy of the retroperitoneal mass: a seminoma was diagnosed on pathological examination. Read More

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Safety of Minimizing Intensity of Follow-up on Active Surveillance for Clinical Stage I Testicular Germ Cell Tumors.

Eur Urol Open Sci 2022 Jun 27;40:46-53. Epub 2022 Apr 27.

Department of Surgery (Urology), Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Background: We have recommended active surveillance as the preferred management option for clinical stage I (CSI) testicular germ cell tumors (GCTs) since 1980. Over time, the recommended intensity of surveillance has decreased; however, the impact on relapse detection has not been investigated.

Objective: To examine relapse rate, time to relapse, extent of disease, and burden of treatment at relapse across decreasing surveillance intensity over time. Read More

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Paratesticular metastasis arising from colonic mucinous adenocarcinoma: a rare case report.

J Int Med Res 2022 May;50(5):3000605221101332

Department of Urology, Jining No. 1 People's Hospital, Jining, Shandong, China.

Colonic mucinous adenocarcinoma rarely metastasizes to the paratesticular region, highlighting the importance of a correct diagnosis. We herein present a case involving a 65-year-old man with paratesticular carcinoma associated with scrotal swelling 1 year after radical resection of colon cancer. Computed tomography revealed a low-density tumor in the right scrotum and mild enhancement of the mass after administration of a contrast agent. Read More

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Predicting malignancy in small testicular lesions.

Cent European J Urol 2022 22;75(1):47-51. Epub 2022 Feb 22.

Department of Urology, Pontificate Catholic University, Santiago, Chile.

Introduction: Small testicular lesions ≤20 mm (STL) detected by ultrasound (US), usually non-palpable, have been reported to be benign in up to 80% of cases. Thus, partial orchiectomy with or without frozen section examination and surveillance has been advocated for these kinds of lesions. We seek to report the proportion of benign lesions in testicular tumors ≤20 mm detected by US in our population and explore the predicting factors of malignancy. Read More

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February 2022

ACR Appropriateness Criteria® Staging and Surveillance of Testicular Cancer: 2021 Update.

J Am Coll Radiol 2022 05;19(5S):S194-S207

Specialty Chair, University of Alabama at Birmingham, Birmingham, Alabama; Chair, ACR Appropriateness Committee.

The staging and surveillance of testicular cancer is a complex topic, which integrates clinical, biochemical, and imaging components. The use of imaging for staging and surveillance of testicular cancer is individually tailored to each patient by considering tumor histology and prognosis. This document discusses the rationale for use of imaging by imaging modality during the initial staging of testicular seminoma and nonseminoma tumors and during the planned surveillance of stage IA and IB testicular cancer by histological subtype integrating clinical suspicion for disease recurrence in surveillance protocols. Read More

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Precocious puberty related to Leydig cell testicular tumor: the diagnostic imaging keys.

Eur J Med Res 2022 May 12;27(1):67. Epub 2022 May 12.

Service de Radiologie, APHP Hôpitaux Paris Saclay, Hôpital Antoine Béclère, 157 rue de la porte de trivaux, 92140, Clamart, France.

Background: We report the challenging case of a 6-year-old boy with precocious puberty related to histologically proven Leydig cell tumor.

Case Presentation: Multiparametric ultrasound and magnetic resonance imaging (MRI) was performed. Interesting findings were scarcely or never reported in children and differed from adults Leydig cell tumors s such as the hyperechogenic halo surrounding the lesion and the dominant central vascularization using ultrasensitive Doppler. Read More

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Metastatic Potential of Small Testicular Germ Cell Tumors: Implications for Surveillance of Small Testicular Masses.

Eur Urol Open Sci 2022 Jun 26;40:16-18. Epub 2022 Apr 26.

Department of Medical Oncology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Incidental detection of urogenital tumors has increased in recent decades owing to the greater use of ultrasonography and cross-sectional imaging. For patients with low-risk prostate cancer or small renal masses, active surveillance represents a valid treatment option. Similarly, for men with small testicular masses <10 mm, active surveillance has been discussed as an alternative to surgery, although little is known regarding the behavior of small testicular germ cell tumors (GCTs). Read More

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Primary seminoma of prostate in a patient with Klinefelter syndrome: A case report.

Medicine (Baltimore) 2022 Apr 29;101(17):e29117. Epub 2022 Apr 29.

Department of Urology, Capital Medical University Affiliated Beijing Shijitan Hospital, No. 10 Yangfangdian Road, Haidian District, Beijing, PR China.

Rationale: Klinefelter syndrome (KS) is a sex differentiation syndrome that occurs in men and is characterized by the 47XXY genotype. An association between KS and cancer has also been reported. The occurrence of seminoma of the prostate in KS has not been reported in the literature to date. Read More

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Elevated HCG and retroperitoneal adenopathy after clomiphene therapy for infertility.

BMJ Case Rep 2022 Apr 26;15(4). Epub 2022 Apr 26.

Division of Urology, University Health Network, Toronto, Ontario, Canada.

In the context of an elevated human chorionic gonadotropin (HCG) with enlarged retroperitoneal nodes and absent testicular tumours, clinicians will consider a diagnosis of extragonadal germ cell tumours. We report the case of a man in his thirties who while on treatment for subfertility with clomiphene citrate was noted to have enlarged retroperitoneal nodes and elevated HCG levels of 75 IU/L. Chemotherapy with bleomycin, etoposide and cisplatin originally planned was deferred when two separate retroperitoneal nodal biopsies returned as benign fibroadipose tissue and HCG levels spontaneously down-trended to 4 IU/L within 4 months of clomiphene citrate discontinuation. Read More

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Whole-Exome Sequencing Identifies the VHL Mutation (c.262T > C, p.Try88Arg) in Non-Obstructive Azoospermia-Associated Cystic Renal Cell Carcinoma.

Curr Oncol 2022 03 28;29(4):2376-2384. Epub 2022 Mar 28.

Department of Urology, Medical School of Nanjing University Affiliated Jinling Hospital, Nanjing 210002, China.

Von Hippel-Lindau (VHL) genes are intimately involved in renal cell carcinoma (RCC), including clear cell RCC (ccRCC) pathogenesis. However, the contribution of pathogenic VHL mutations to ccRCC remains poorly understood. We report a xanthoderm with non-obstructive azoospermia (NOA)-associated cystic ccRCC, and the missense VHL mutation (c. Read More

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A case of cerebrotendinous xanthomatosis with brain and spinal involvement without tendon xanthomas: Identification of a novel mutation of the CYP27A1 gene.

J Clin Lipidol 2022 May-Jun;16(3):281-285. Epub 2022 Apr 3.

Department of Neurology, 417 Army Share Fund Hospital, 10-12 Monis Petraki Str., PO 11521, Athens, Greece.

Cerebrotendinous xanthomatosis (CTX) is a rare inherited disorder of the alternative pathway of bile acid biosynthesis, due to mutation(s) of the gene CYP27A1, leading to sterol 27-hydroxylase deficiency. The latter results in a systematic deposition of cholestanol and cholesterol to the central nervous system and tendons, premature cataract, as well as the manifestation of systematic symptoms, such as chronic diarrhea, osteoporosis, and premature atherosclerosis. Due to its marked clinical heterogeneity, prompt diagnosis of this disorder is challenging. Read More

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Diffusion-Weighted MRI in the Genitourinary System.

J Clin Med 2022 Mar 30;11(7). Epub 2022 Mar 30.

Division of Radiology, Geneva University Hospitals and University of Geneva, 1205 Geneva, Switzerland.

Diffusion weighted imaging (DWI) constitutes a major functional parameter performed in Magnetic Resonance Imaging (MRI). The DW sequence is performed by acquiring a set of native images described by their b-values, each b-value representing the strength of the diffusion MR gradients specific to that sequence. By fitting the data with models describing the motion of water in tissue, an apparent diffusion coefficient (ADC) map is built and allows the assessment of water mobility inside the tissue. Read More

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Pathologic Conditions at Imaging of the Spermatic Cord.

Radiographics 2022 May-Jun;42(3):741-758. Epub 2022 Apr 8.

From the Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar St, PO Box 208042, Room TE-2, New Haven, CT 06520 (N.K., N. Solomon, M.V.R.); Stanford University, Stanford, Calif (N. Segaran); Zucker School of Medicine at Hofstra/Northwell, Department of Radiology, Northwell Health System, Manhasset, NY (J.S.P.); Department of Radiology, NYU Winthrop University Hospital, Mineola, NY (D.S.K.); and Department of Radiology, University of Washington Medical Center, Seattle, Wash (M.M.).

A wide range of benign and malignant processes can affect the spermatic cord (SC). Familiarity with and recognition of the characteristic imaging features of these entities are imperative for accurate diagnosis and optimal clinical care. While some SC diseases are self-limiting, others can result in infertility and potentially life-threatening infection or bleeding if they are left untreated. Read More

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[Follow-up of testicular germ cell tumors-historical aspects and current recommendations].

Urologe A 2022 May 6;61(5):484-494. Epub 2022 Apr 6.

Klinik für Urologie und Kinderurologie, Universitätsklinikum Ulm, Ulm, Deutschland.

Systematic follow-up examinations of patients cured of testicular cancer first gained attention by caregivers in the 1980s only after the management of the disease had significantly been improved by the introduction of cisplatin-based chemotherapy and almost synchronously, by the implementation of computerized tomography (CT) and serum tumor markers. Follow-up involves three aims: early diagnosis of recurrence, detection of treatment-related toxicity, and detection of secondary diseases. As the clinical presentation of testicular cancer is very heterogeneous, there is no uniform follow-up for the disease. Read More

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Surgical Resection of a Third Ventricle Nongerminomatous Germ Cell Tumor: Two-Dimensional Operative Video.

World Neurosurg 2022 Jul 30;163. Epub 2022 Mar 30.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; National Center for Neurological Disorders, Shanghai, China; Neurosurgical Institute of Fudan University, Shanghai, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China; Research Unit of New Technologies of Micro-Endoscopy Combination in Skull Base Surgery (2018RU008), Chinese Academy of Medical Sciences, Shanghai, China; Department of Neurosurgery, Fujian Campus of National Regional Medical Center, Huashan Hospital, Fudan University, Fuzhou, Fujian, China. Electronic address:

Surgical resection of a pineal tumor growing into the third ventricle is difficult owing to the complex neurovascular structures, and nongerminomatous germ cell tumor is the most common malignant tumor in pediatric patients. Removing the tumor efficiently with minimal blood loss while protecting the surrounding neurovascular structure is challenging. We present a surgical case of a 9-year-old patient with a third ventricle nongerminomatous germ cell tumor (Video). Read More

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Leiomyosarcoma of the spermatic cord: a rare paratesticular neoplasm case report.

World J Surg Oncol 2022 Mar 25;20(1):94. Epub 2022 Mar 25.

Department of Urology, Galway University Hospital, Galway, Ireland.

Background: Primary soft tissue sarcomas contribute to only 2% of all malignancies arising from the male genitourinary tract. Leiomyosarcoma (LMS) is a malignant soft tissue neoplasm which originates from the mesenchyme and has a characteristic smooth muscle differentiation. Usually, it presents as a painless, firm, slow-growing unilateral scrotal mass. Read More

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"The Benefit Of Positron Emission Tomography/Computed Tomography In Stage I And Stage II Melanomas With High-Risk Decisiondx-Melanoma Scores".

Am Surg 2022 Jul 23;88(7):1446-1451. Epub 2022 Mar 23.

12355West Virginia University School of Medicine, Morgantown, WV, USA.

Introduction: Early detection of melanoma is instrumental as the 5-year survival decreases from 93.3% to <50% when metastases are present. Distinguishing which patients require closer follow-up can be difficult for melanoma patients. Read More

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Microcystic stromal tumour of testis.

BMJ Case Rep 2022 Mar 18;15(3). Epub 2022 Mar 18.

Pathology, University Medical Center Groningen, Groningen, The Netherlands.

Within the group of gonadal sex cord-stromal tumours, microcystic stromal tumour (MCST) is a rare entity. In the literature, most case series and reviews discussed MCST arising in the ovary, only one case-report concerned a testicular MCST. We present a Caucasian man in his late 30s, who presented with an MCST in his right testis. Read More

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Bilateral congenital cryptorchidism and unilateral Leydig cell tumor in an adult presenting with gynecomastia and primary infertility: A case report.

Int J Surg Case Rep 2022 Apr 9;93:106923. Epub 2022 Mar 9.

Department of Oncology, Aga Khan University, Karachi, Pakistan.

Introduction And Importance: The neoplasms of the testis are sporadic tumors among men. Furthermore, the rarest subset of these is neoplasms belonging to the stromal tumors of the sex cord. Leydig cell tumors are the most common form among the testicular stromal tumors. Read More

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[Clinical Characterization of Patients with Ovarian Mass Combined with Dysplasia of Secondary Sexual Characteristics].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2022 Feb;44(1):17-23

Department of Obstetrics and Gynecology,National Clinical Research Center for Obstetric and Gynecologic Diseases,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Objective To investigate the clinical characteristics of preadolescent and adolescent female patients with ovarian mass combined with dysplasia of secondary sexual characteristics. Methods This study retrospectively analyzed 18 cases of ovarian mass combined with dysplasia of secondary sexual characteristics aged 0-19 years admitted to Peking Union Medical College Hospital from January 2012 to November 2019.By analyzing the clinical manifestations,surgical methods,postoperative pathology,therapies and prognosis of the cases,we summarized the diagnosis and treatment ideas. Read More

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February 2022

Intravascular Ultrasound for the Evaluation and Management of Retroperitoneal, Genitourinary Malignancies.

Curr Urol Rep 2022 May 14;23(5):67-73. Epub 2022 Mar 14.

Department of Urology, Faculty Office Tower 1107, University of Alabama at Birmingham, 510 20th Street South, Birmingham, AL, USA.

Purpose Of Review: Herein we provide a review of intravascular ultrasound (IVUS) and its ability to assist in the evaluation and surgical management of advanced retroperitoneal, genitourinary tumors.

Recent Findings: Advanced retroperitoneal tumors such as advanced renal cell carcinoma, bulky retroperitoneal lymphadenopathy associated with advanced testicular carcinoma, large adrenal tumors, and retroperitoneal sarcomas can invade, compress, or distort vascular anatomy making surgical resection challenging and high risk. Intravascular ultrasonography is commonly used by vascular and cardiothoracic surgery to provide a real time assessment of vascular invasion, compression, and aberrant anatomy to assist with pre-operative and/or intraoperative decision-making. Read More

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[Modern tomography imaging techniques in urological diseases].

Urologe A 2022 Apr 9;61(4):374-383. Epub 2022 Mar 9.

Radiologisches Institut, Universitätsklinikum Erlangen, Erlangen, Deutschland.

Background: Radiologic imaging is important for the detection, staging and follow-up of urological tumors. Basic therapy decisions for both oncological (surgical vs. systemic therapy, e. Read More

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Primary paratesticular neuroblastoma in a newborn - case presentation and literature review.

Pediatr Neonatol 2022 05 6;63(3):315-316. Epub 2022 Jan 6.

Clinical Children's Hospital of Brasov, Romania; Transilvania University of Brasov Romania, Romania.

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Diffusion-Weighted MRI in Patients with Testicular Tumors-Intra- and Interobserver Variability.

Curr Oncol 2022 02 2;29(2):837-847. Epub 2022 Feb 2.

Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark.

In general, magnetic resonance (MR) diffusion-weighted imaging (DWI) has shown potential in clinical settings. In testicles parenchyma, the DW imaging helps differentiate and characterize benign from malignant lesions. Placement and size of the region of interest (ROI) may affect the ADC value. Read More

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February 2022

[Magnetic resonance imaging accuracy and utility for testicular cancer diagnosis].

Rev Int Androl 2022 Apr-Jun;20(2):128-135. Epub 2022 Feb 16.

Servicio de Diagnóstico por Imágenes, Buenos Aires, Argentina.

Purpose: The purpose of our study is to analyze the imaging findings described in MRI and the histopathologic type of testicular lesions to determine which findings are the best predictors of malignancy.

Materials And Methods: Forty six (46) patients with testicular lesions were initially studied with ultrasound (US) and with testicular MRI (tMRI) on a 1.5-T magnet. Read More

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Splenogonadal fusion in an infant

Orv Hetil 2022 02 13;163(7):288-290. Epub 2022 Feb 13.

3 Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ, Gyermekgyógyászati Klinika, Gyermek Manuális Tanszék Pécs Magyarország.

Összefoglaló. A splenogonadalis fúzió ritka fejlődési rendellenesség, melynek lényege az ivarmirigy (leggyakrabban a here) és a lépszövet rendellenes kapcsolódása. A szerzők egy féléves csecsemő esetét kívánják bemutatni, akinél már a megszületést követően észlelhető volt a bal oldali here megnagyobbodása. Read More

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February 2022

Management of the undescended testis in children: An American Pediatric Surgical Association Outcomes and Evidence Based Practice Committee Systematic Review.

J Pediatr Surg 2022 Jul 15;57(7):1293-1308. Epub 2022 Jan 15.

Division of Pediatric Surgery, BC Children's Hospital, University of British Columbia, Vancouver, BC, United States.

Purpose: Management of undescended testes (UDT) has evolved over the last decade. While urologic societies in the United States and Europe have established some guidelines for care, management by North American pediatric surgeons remains variable. The aim of this systematic review is to evaluate the published evidence regarding the treatment of (UDT) in children. Read More

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Detection of a second primary cancer in a 18F-fluorocholine PET/CT - multicentre retrospective analysis on a group of 1345 prostate cancer patients.

Nucl Med Rev Cent East Eur 2022 ;25(1):25-30

Department of Nuclear Medicine, Affidea Poznan, Poland.

Background: Aim of this study was to evaluate the rate of incidental detection of second primary cancer (SPC) at 18F-fluorocholine ([18F]FCH) positron emission tomography/computed tomography (PET/CT) performed in prostate cancer patients.

Material And Methods: A retrospective analysis was performed on a group of 1345 prostate cancer patients, who underwent [18F]FCH PET/CT study because of suspicion of recurrence (n = 937) or for initial staging (n = 408). Images were acquired after intravenous injection [18F]FCH with a mean activity of 200 ± 75 MBq (5. Read More

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February 2022