3,276 results match your criteria Malignant Testicular Tumor Imaging


Diagnostic performance of multi-parametric MRI to differentiate benign sex cord stromal tumors from malignant (non-stromal and stromal) testicular neoplasms.

Abdom Radiol (NY) 2020 Jun 22. Epub 2020 Jun 22.

Department of Radiology, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

Purpose: Testicular stromal tumors are uncommon, although mostly benign. The purpose of this study is to assess the role of multi-parametric MRI in differentiating benign testicular stromal tumors from malignant testicular neoplasms (non-stromal and stromal).

Methods: A single-center retrospective study comparing benign stromal tumors (STs) to malignant testicular neoplasms (MTNs) was conducted. Read More

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http://dx.doi.org/10.1007/s00261-020-02621-4DOI Listing

[De-escalation: Testicular cancer.]

Arch Esp Urol 2020 Jun;73(5):390-394

Department of Urology. Istanbul Medipol University. Estambul. Turquía. Amsterdam UMC. University of Amsterdam. Amsterdam. Holanda.

Objectives: To provide a priority algorithm for determinate diagnostic, therapeutic and follow-up procedures regarding at testicular cancer, adjusted by institutional requirements. Testicular cancer patient assessment during COVID-19 Pandemia.

Material And Methods: Review of relevant manuscript published up to date, draft creation correctedt hough modified nominal group until final corrected manuscript. Read More

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Intratesticular leiomyoma: A case report and a literature review.

Int J Surg Case Rep 2020 23;71:217-221. Epub 2020 May 23.

Urology Department, Sahloul Hospital, Sousse, Tunisia.

Introduction: Leiomyomas are benign tumors that originate from smooth muscles cells. Intratesticular leiomyoma is a very rare type of benign testicular masses. Through the literature, only 11 cases were reported. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262370PMC

Embryonal carcinoma of an intraabdominal testicular tumor on an undescended testicle: a case report.

Med Pharm Rep 2020 Apr 22;93(2):213-218. Epub 2020 Apr 22.

Department of Medical Imaging, Iuliu Hatieganu University of Medicine and Pharmacy, "Prof. Dr. Octavian Fodor", Regional Institute of Gastroenterology and Hepatology Cluj-Napoca, Romania.

Cryptorchidism, as a singular pathology or associated with other dysgenesis syndromes, is one of the main factors of risk for the development of the testicular tumors. Although there are a great number of cases of undescended testicles that are diagnosed and treated during the first 6-12 months of life, there are rare cases of adults who are undiagnosed and untreated from this anomaly, which can present a high risk of malignancy. In this study we present the case of a 36-year-old patient, diagnosed at puberty with left cryptorchidism, untreated, who also hadevidenced a large intraabdominal tumoral mass associated with it. Read More

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http://dx.doi.org/10.15386/mpr-1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243893PMC

Young Man With Intermittent Flank Pain.

Ann Emerg Med 2020 06;75(6):e31-e32

Department of Emergency, School of Medicine, College of Medicine, Taipei, Taiwan; Emergency Department, Department of Emergency and Critical Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.annemergmed.2019.12.009DOI Listing

Multiparametric ultrasonographic analysis of testicular tumors: a single-center experience in a collective of 49 patients.

Scand J Urol 2020 Jun 25;54(3):241-247. Epub 2020 May 25.

Department of Radiology, Ludwig-Maximilians-University Munich - Grosshadern Campus, Munich, Germany.

The aim of the present retrospective single-center study is to evaluate the diagnostic performance of multiparametric ultrasonography for characterizing testicular tumors. Forty-nine patients with testicular tumors, 36 of malignant vs 13 of benign entity, were included in this retrospective single-center study on whom multiparametric sonography, encompassing native B-mode, Color Doppler, contrast-enhanced ultrasound (CEUS) and elastography, was performed between 2011-2018. In 48 of 49 patients, findings from multiparametric analysis were correlated with histopathological results. Read More

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http://dx.doi.org/10.1080/21681805.2020.1765863DOI Listing

Incidental Testicular Pathologies in Patients With Idiopathic Hydrocele Testis: Is Preoperative Scrotal Ultrasound Justified?

Anticancer Res 2020 May;40(5):2861-2864

Department of Urology, Medical University Innsbruck, Innsbruck, Austria

Background/aim: Hydrocele testis is a common disease with a prevalence of 1% in adults. Although it can be diagnosed by physical examination, scrotal ultrasound represents a standard diagnostic tool, to exclude underlying pathologies among them testicular or scrotal malignancies.

Patients And Methods: We conducted a retrospective analysis of 156 patients aged between 20 and 60 years who underwent surgical hydrocelectomy between 2003 and 2018. Read More

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http://dx.doi.org/10.21873/anticanres.14261DOI Listing

Infant With Abdominal Fullness.

Ann Emerg Med 2020 05;75(5):e27-e28

Division of Emergency Medicine, Department of Surgery, Duke University Hospital, Durham, NC.

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http://dx.doi.org/10.1016/j.annemergmed.2019.11.005DOI Listing

[Retroperitoneal lymph node assessment in pediatric paratesticular rhabdomyosarcoma].

Bull Cancer 2020 Jun 14;107(6):666-671. Epub 2020 Apr 14.

Hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, université Paris-Saclay, chirurgie pédiatrique, 78, rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, France.

Paratesticular Rhabdomyosarcoma accounts for 7 to 11% of pediatric rhabdomyosarcomas. Children older than 10 years have a worse event-free survival (69 to 80% vs. 87 to 92%) than children younger than 10 years. Read More

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http://dx.doi.org/10.1016/j.bulcan.2020.03.007DOI Listing

The role of multiparametric ultrasound in the diagnosis of paediatric scrotal pathology.

Br J Radiol 2020 Jun 23;93(1110):20200063. Epub 2020 Apr 23.

Department of Radiology, King's College Hospital, London. Denmark Hill, London SE5 9RS U.K, United Kingdom.

Multiparametric ultrasound (MPUS), combining conventional techniques (greyscale and colour Doppler ultrasound), ultrasound strain elastography, and contrast-enhanced ultrasound (CEUS), has been successfully used in the assessment of adult scrotal pathology. Contrast-enhanced ultrasound can confidently establish testicular tissue vascularity even in the small-volume paediatric testis. Elastography provides further assessment of tissue stiffness, potentially adding useful diagnostic information. Read More

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http://dx.doi.org/10.1259/bjr.20200063DOI Listing
June 2020
1.533 Impact Factor

Pulmonary metastasis: very late relapse of testicular embryonal carcinoma.

Monaldi Arch Chest Dis 2020 Apr 8;90(1). Epub 2020 Apr 8.

Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples.

Testicular carcinoma recurrences represent a rare finding (1-6% in non-seminomatous germ cell tumours). However, cases of recurrence have been described many years later. We report a case of late recurrence of embryonic testicular carcinoma, after 26 years, with pulmonary metastases. Read More

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http://dx.doi.org/10.4081/monaldi.2020.1206DOI Listing

[Ultrasound characteristics of testicular Leydig cell tumors , , , 1.]

Zhonghua Nan Ke Xue 2019 Apr;25(5):346-350

Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.

Objective: To explore the color Doppler ultrasonic characteristics of testicular Leydig cell tumors (LCT) and improve the clinical diagnosis of the disease.

Methods: We retrospectively analyzed 4 cases of testicular LCT diagnosed and treated in our hospital and summarized the experience in the ultrasonic diagnosis of LCT with a review of the relevant literature.

Results: All the 4 testicular LCTs were solitary and quasi-round, 1 in the left and 3 in the right. Read More

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Primary testicular diffuse large B-cell lymphoma: Case series.

Medicine (Baltimore) 2020 Mar;99(12):e19463

Department of Pathology.

Rationale: Primary testicular lymphoma (PTL) is a rare type of extranodal non-Hodgkin's lymphoma (NHL). Although data of PTL in patients with diffuse large B-cell lymphoma (DLBCL) are accumulating, there are still patients respond poorly to prognosis.

Patient Concerns: All patients had disease of the DLBCL subtype and those patients had primary involvement of the testis. Read More

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http://dx.doi.org/10.1097/MD.0000000000019463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220436PMC

Muscular involvement of extranodal natural killer/T cell lymphoma misdiagnosed as polymyositis: A case report and review of literature.

World J Clin Cases 2020 Mar;8(5):963-970

Department of Neurology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China.

Background: Natural killer (NK)/T cell lymphoma is a rare and highly aggressive malignant tumor, and is a special form of non-Hodgkin's lymphoma. Although extranodal involvement is frequently found in tissues such as the skin, testicular and gastrointestinal tract , its presence in skeletal muscle has scarcely been reported in the literature.

Case Summary: We report a case of extranodal NK/T cell lymphoma with muscle swelling as the first clinical manifestation. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i5.963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062622PMC

Incidental testicular doses during volumetric-modulated arc radiotherapy in prostate cancer patients.

Radiol Med 2020 Aug 3;125(8):777-783. Epub 2020 Mar 3.

Adana Dr. Turgut Noyan Research and Treatment Center, Department of Radiation Oncology, Baskent University Faculty of Medicine, 01120, Adana, Turkey.

Purpose: To compare the incidental testicular doses during volumetric-modulated arc therapy (VMAT) in patients receiving prostate-only and pelvic lymphatic irradiation.

Materials And Methods: Testicular doses in 40 intermediate- and high-risk prostate cancer patients were determined on treatment planning system (TPS) using the VMAT technique at 6 MV. Scattered testicular doses were also measured by MOSFET detectors placed on testis surface. Read More

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http://dx.doi.org/10.1007/s11547-020-01158-2DOI Listing

Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma.

Case Rep Neurol Med 2020 27;2020:1792582. Epub 2020 Jan 27.

Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Primary intradural malignant peripheral nerve sheath tumor (MPNST) is an extremely rare diagnosis and is associated with an extremely poor prognosis. A 77-year-old man diagnosed with an intradural MPNST, more than 40 years after radiation for a testicular seminoma, is reported. Intradural MPNSTs of the spine outside the setting of neurofibromatosis is extremely rare and can masquerade as common benign nerve sheath tumors, on imaging. Read More

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http://dx.doi.org/10.1155/2020/1792582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007932PMC
January 2020

Lifetime Transfusion Burden and Transfusion-Related Iron Overload in Adult Survivors of Solid Malignancies.

Oncologist 2020 Feb 27;25(2):e341-e350. Epub 2019 Aug 27.

Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.

Background: Limited data exist on transfusion burden and transfusion-related iron overload in adult survivors of solid malignancies.

Methods: Hospital-specific cancer registry data of patients with solid tumor receiving systemic anticancer treatment between January 2008 and September 2009 at the Oncology Department of the Leiden University Medical Center (The Netherlands) were retrieved and cross-referenced with red blood cell (RBC) transfusion records. Individual lifetime transfusion burden was captured in April 2015. Read More

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http://dx.doi.org/10.1634/theoncologist.2019-0222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011667PMC
February 2020

Sciatic pain by neurolymphomatosis as initial presentation of disseminated diffuse large B cell lymphoma involving the testis and the CNS.

Hematol Oncol 2020 Apr 5;38(2):197-200. Epub 2020 Feb 5.

Oncology Institute of Southern Switzerland (IOSI), Medical Oncology, Imaging Institute of Southern Switzerland, Bellinzona, Switzerland.

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http://dx.doi.org/10.1002/hon.2698DOI Listing

Paratesticular Mesenchymal Malignancies: A Single-Center Case Series, Clinical Management, and Review of Literature.

Integr Cancer Ther 2020 Jan-Dec;19:1534735419900554

Sant'Orsola-Malpighi Hospital, Bologna, Italy.

Primary soft tissue sarcomas arising from the male urinary and genital tract are rare tumors, only accounting for 1% to 2% of all malignancies of the genitourinary tract. Clinical management of advanced disease is lacking in standardized recommendations due to the rarity of the disease. To date, complete and extensive surgery represents the only curative and standardized approach for localized disease, while the impact of retroperitoneal lymphadenectomy and adjuvant treatments on clinical outcomes are still unclear. Read More

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http://dx.doi.org/10.1177/1534735419900554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050957PMC

[Intimal sarcoma of pulmonary arteries].

Orv Hetil 2020 Feb;161(6):232-236

Pathologiai Intézet, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Állomás u. 1., 6725.

Pulmonary arterial intimal sarcoma is a rare tumour with high mortality. Due to its localisation, the symptoms can mimic pulmonary thromboembolism and pneumonia, therefore assessing the diagnosis and choosing the adequate therapy is never easy. Its therapy mainly consists of surgery combined with radiochemotherapy. Read More

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http://dx.doi.org/10.1556/650.2020.31642DOI Listing
February 2020

Rare benign and malignant testicular lesions: histopathology and management.

Curr Opin Urol 2020 Mar;30(2):235-244

Department of Urology.

Purpose Of Review: The presence of vascular solid tumors within the testicle is considered to be malignant until proven otherwise. However, it is prudent for clinicians to be aware of rare benign and malignant intratesticular lesions as management can differ from the established treatment algorithms for germ-cell tumors.

Recent Findings: Utilizing certain histopathologic findings can assist with the diagnosis of rare testis tumors. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000715DOI Listing

Imaging of scrotal masses.

Abdom Radiol (NY) 2020 Jul;45(7):2087-2108

Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Testicular cancer is responsible for approximately 0.1% of all cancer deaths in the USA, and seminoma is the most common type of testicular tumor. Ultrasonography is the primary imaging modality for accessing testicular and extratesticular lesions, while magnetic resonance imaging can be used for problem solving in lesion characterization in certain cases. Read More

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http://dx.doi.org/10.1007/s00261-019-02395-4DOI Listing

Occurrence of paratesticular ganglioneuroma 18 years after concurrent adrenal ganglioneuroma and papillary thyroid carcinoma - a case report.

BMC Cancer 2019 Dec 30;19(1):1265. Epub 2019 Dec 30.

Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, No.386, Ta-Chung 1st Rd, 81362, Kaohsiung, Taiwan.

Background: Ganglioneuromas (GNs) are composed of mature ganglion cells and Schwann cells with a fibrous stroma; GNs are most often observed in children and young adults. The majority of non-cranial GNs are located in the retroperitoneum and posterior mediastinum. Other reported rare sites include the adrenal gland, small intestine, colon and urinary bladder. Read More

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http://dx.doi.org/10.1186/s12885-019-6440-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937970PMC
December 2019
3.362 Impact Factor

[Management of residual masses of testis germ cell tumors].

Bull Cancer 2020 Feb 24;107(2):215-223. Epub 2019 Dec 24.

Hôpital Nord, service d'urologie, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France.

A residual mass (RM) is an abnormal image with a transverse axis of more than 1cm trans that remains visible on the CT scan performed after chemotherapy for metastatic germ cell tumors. Their management depends on the histology of the initial tumor. In the case of a non-seminomatous germ cell tumor, all residual lesions must be resected if the tumor markers are negative. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.10.010DOI Listing
February 2020

Renal interstitial cell tumor in a dog: clinicopathologic, imaging, and histologic features.

J Vet Diagn Invest 2020 Jan 26;32(1):124-127. Epub 2019 Dec 26.

Small Animal Tumor Diagnostic Center, Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea (Cho, Seung, Kim, Lim, Sur).

Renal interstitial cell tumors are benign tumors of renomedullary origin; however, malignant features have not been reported in dogs, to our knowledge. A 17-y-old spayed female Maltese dog was presented to a local animal hospital with a mass in the right abdomen. Clinicopathologic findings prior to surgery revealed renal insufficiency and anemia. Read More

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http://dx.doi.org/10.1177/1040638719897585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003225PMC
January 2020

T2-Weighted Image-Based Radiomics Signature for Discriminating Between Seminomas and Nonseminoma.

Front Oncol 2019 28;9:1330. Epub 2019 Nov 28.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

To evaluate the performance of a T2-weighted image (T2WI)-based radiomics signature for differentiating between seminomas and nonseminomas. In this retrospective study, 39 patients with testicular germ-cell tumors (TGCTs) confirmed by radical orchiectomy were enrolled, including 19 cases of seminomas and 20 cases of nonseminomas. All patients underwent 3T magnetic resonance imaging (MRI) before radical orchiectomy. Read More

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http://dx.doi.org/10.3389/fonc.2019.01330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901122PMC
November 2019

Radiomics allows for detection of benign and malignant histopathology in patients with metastatic testicular germ cell tumors prior to post-chemotherapy retroperitoneal lymph node dissection.

Eur Radiol 2020 Apr 11;30(4):2334-2345. Epub 2019 Dec 11.

Department of Urology, University Hospital of Cologne, Cologne, Germany.

Objectives: To evaluate whether a computed tomography (CT) radiomics-based machine learning classifier can predict histopathology of lymph nodes (LNs) after post-chemotherapy LN dissection (pcRPLND) in patients with metastatic non-seminomatous testicular germ cell tumors (NSTGCTs).

Methods: Eighty patients with retroperitoneal LN metastases and contrast-enhanced CT were included into this retrospective study. Resected LNs were histopathologically classified into "benign" (necrosis/fibrosis) or "malignant" (viable tumor/teratoma). Read More

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http://dx.doi.org/10.1007/s00330-019-06495-zDOI Listing

Intrascrotal lipoblastoma in adulthood.

BMJ Case Rep 2019 Dec 10;12(12). Epub 2019 Dec 10.

Pathology, Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Coimbra, Portugal.

This case report describes the case of a 37-year-old man that noticed an intrascrotal right mass with 1 month of evolution. During physical exam presented with a large mass at the inferior portion of the right testicle, clearly separated from the testicle, with a tender consistency and mobile. An ultrasound was performed that showed a solid and subcutaneous nodular lesion, extra testicular, heterogeneous, measuring 7. Read More

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http://dx.doi.org/10.1136/bcr-2019-231320DOI Listing
December 2019

Re: MRI in the Follow-up of Testicular Cancer: Less is More.

Authors:
Jerome P Richie

J Urol 2020 03 3;203(3):464-465. Epub 2019 Dec 3.

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http://dx.doi.org/10.1097/JU.0000000000000678DOI Listing

Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.

World Neurosurg 2020 Feb 18;134:e360-e371. Epub 2019 Nov 18.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:

Background: The term "growing teratoma syndrome (GTS)" has been used as follows: patients with germ cell tumor (GCT) who present with enlarging original/metastatic masses during or after appropriate systemic chemotherapy despite normalized serum markers. In other words, the definition of the term GTS is not fully established. We analyzed and reviewed our case series regarding GTS that developed after the treatment of central nervous system (CNS) nongerminoatous germ cell tumors (NGGCTs). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.10.074DOI Listing
February 2020
2.417 Impact Factor

Imaging of the acute scrotum: keys to a rapid diagnosis of acute scrotal disorders.

Abdom Radiol (NY) 2020 Jul;45(7):2063-2081

Section of Abdominal Imaging, Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.

Imaging of the scrotum in the setting of acute symptoms such as pain or swelling is commonly performed emergently to differentiate between patients who require immediate surgery and those that do not. Acute scrotal symptoms are generally caused by infectious, traumatic or vascular etiologies. Rapid diagnosis and initiation of treatment is vital for testicular salvage in cases of acute testicular torsion, testicular rupture, and Fournier gangrene. Read More

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http://dx.doi.org/10.1007/s00261-019-02333-4DOI Listing

Absence of Testicular Adrenal Rest Tumors in Newborns, Infants, and Toddlers with Classical Congenital Adrenal Hyperplasia.

Horm Res Paediatr 2019 20;92(3):157-161. Epub 2019 Nov 20.

Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

Introduction: Testicular adrenal rest tumors (TART) are a known consequence for males with classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. TART are associated with potential infertility in adults. However, little is known about TART in very young males with CAH. Read More

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http://dx.doi.org/10.1159/000504135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004842PMC

Pituitary Dysfunction Among Men Presenting with Hypogonadism.

Curr Urol Rep 2019 Nov 16;20(11):78. Epub 2019 Nov 16.

Division of Endocrinology, Diabetes, and Bone & Mineral Disorder, Henry Ford Medical Center--New Center One, 3031 W. Grand Blvd, Detroit, MI, 48202, USA.

Purpose Of Review: Hypogonadism is a common endocrine dysfunction. This review focuses on the most up-to-date guideline for evaluation of pituitary function among men presenting with signs and symptoms of hypogonadism.

Recent Findings: The clinician must differentiate between primary (testicular) and secondary (pituitary-hypothalamic or central) hypogonadisms and be aware of adult-onset hypogonadism. Read More

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http://dx.doi.org/10.1007/s11934-019-0935-zDOI Listing
November 2019

[Contrast-enhanced ultrasonography of testicular tumours].

Authors:
G Lock

Urologe A 2019 Dec;58(12):1410-1417

Klinik für Innere Medizin, Albertinen-Krankenhaus Hamburg, Süntelstr. 11a, 22457, Hamburg, Deutschland.

Scrotal ultrasound with high-resolution transducers and additional display of vascularisation in colour-coded ultrasonography is the method of choice for the detection and characterisation of testicular tumors. Within the last decade, testicular ultrasonography has been further refined and improved by the possibilities of contrast-enhanced ultrasound (CEUS).CEUS may be especially helpful in the assessment of vascularisation disorders (e. Read More

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http://dx.doi.org/10.1007/s00120-019-01065-zDOI Listing
December 2019

Abdominal cocoon with bilateral cryptorchidism and seminoma in the right testis: a case report and review of literature.

BMC Surg 2019 Nov 11;19(1):167. Epub 2019 Nov 11.

Minimally Invasive Urology Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.

Background: Abdominal cocoon is a rare peritoneal lesion and is difficult to diagnose because of its lack of special clinical manifestations. Until now, there is no case report of abdominal cocoon combined with cryptorchidism and seminoma.

Case Presentation: A case of abdominal cocoon with cryptorchidism and seminoma was diagnosed and treated in our hospital. Read More

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http://dx.doi.org/10.1186/s12893-019-0636-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849259PMC
November 2019

Differentiation of testicular seminoma and nonseminomatous germ cell tumor on magnetic resonance imaging.

Medicine (Baltimore) 2019 Nov;98(45):e17937

Urogenital System Group, Department of Radiology, People's Hospital of Long Hua District.

Magnetic resonance imaging (MRI) has excellent soft tissue resolution, as well as multidirectional and multisequence scanning technology, making it an important supplementary method in the diagnosis of testicular tumor.To explore the utility of preoperative MRI for the differential diagnosis of testicular seminoma and nonseminomatous germ cell tumors (NSGCTs).The medical records from 39 patients with testicular tumors that were examined preoperatively with MRI and treated with urologic surgery at our institution between January 2015 and March 2019 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1097/MD.0000000000017937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855626PMC
November 2019

[A Case of Spermatic Cord Liposarcoma Difficult to Distinguish from Inguinal Hernia].

Hinyokika Kiyo 2019 Sep;65(9):389-392

The Department of Urology, Osaka University Graduate School of Medicine.

A 53-year-old man visited a doctor due to left inguinal enlargement. He was diagnosed with left inguinal hernia with omentum as the content by a computed tomography (CT)scan. He underwent open inguinal hernia repair ; however, an inguinal tumor was diagnosed intraoperatively and was resected as much as possible. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_65_9_389DOI Listing
September 2019

Sonographic features of the testicular adrenal rests tumors in patients with congenital adrenal hyperplasia: a single-center experience and literature review.

Orphanet J Rare Dis 2019 11 6;14(1):242. Epub 2019 Nov 6.

Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1, Dongcheng District, Beijing, 100730, China.

Purpose: Testicular adrenal rests tumor (TART) is a rare kind of benign tumor in the testis. It usually occurred secondary to congenital adrenal hyperplasia (CAH), a hormonal disorder caused by hydroxylase deficiency. As the first-line examination method, ultrasound provides crucial diagnostic information for TART, although misdiagnosis to malignancy is quite common because of its rare prevalence. Read More

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http://dx.doi.org/10.1186/s13023-019-1231-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836335PMC
November 2019

Testicular Metastasis of Pancreatic Carcinoma on FDG-PET/CT.

Clin Nucl Med 2020 Jan;45(1):85-86

From the Department of Nuclear Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College; and Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China.

Pancreatic cancer metastasizing to the testis is extremely rare. We present the case of a 65-year-old man who complained of painless swelling of the left scrotum for 9 months. Scrotal ultrasonography revealed a mass in the left testis. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002820DOI Listing
January 2020
1 Read

Rare presentation of a testicular glomus tumour.

BMJ Case Rep 2019 Nov 2;12(11). Epub 2019 Nov 2.

Department of Pathology, East Kent Hospitals University NHS Foundation Trust, Canterbury, Kent, UK.

Glomus tumours are atypical in extracutaneous locations and very rarely located in reproductive organs. We present an unusual case of an incidentally discovered glomus tumour arising from the testis of a 47-year-old man. The testicular occurrence of this tumour type is not only exceptionally rare but also serves to highlight the debate regarding the optimal management of incidentally discovered small testicular lesions. Read More

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http://dx.doi.org/10.1136/bcr-2019-230935DOI Listing
November 2019

Pelvic lymph nodes and pathways of disease spread in male pelvic malignancies.

Abdom Radiol (NY) 2020 Jul;45(7):2198-2212

Division of Abdominal Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Purpose: Accurate nodal staging for male urogenital malignancies has important implications for therapy and prognosis. Male pelvic malignancies, including prostatic, penile, testicular, and bladder cancer, typically metastasize to regional lymph nodes first which is reported by the N-stage. Spread beyond these groups to non-regional nodes is regarded as M-stage disease. Read More

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http://dx.doi.org/10.1007/s00261-019-02285-9DOI Listing

[Hyperthyroidism as a diagnostic key to advanced choriocarcinoma. An unusual association].

Medicina (B Aires) 2019 ;79(5):411-414

Servicio de Clínica Médica, Sanatorio San José, Buenos Aires, Argentina. E-mail:

Hyperthyroidism is a relatively frequent condition with multiple causes. The most common cause is Graves' disease; followed by hyperthyroid multinodular goiter and toxic adenoma. Association between hyperthyroidism and cancer is infrequent in daily practice. Read More

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December 2019
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Performance Characteristics of Clinical Staging Modalities for Early Stage Testicular Germ Cell Tumors: A Systematic Review.

J Urol 2020 05 14;203(5):894-901. Epub 2020 Oct 14.

The Johns Hopkins Evidence-Based Practice Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Purpose: We synthesized evidence on the comparative performance characteristics, benefits and harms of diagnostic imaging modalities used in combination with serum tumor markers for clinical staging of testicular germ cell tumors. The diagnostic imaging modalities included computerized tomography, magnetic resonance imaging, positron emission tomography and chest radiographs.

Materials And Methods: Paired reviewers independently searched PubMed, Embase® and the Cochrane Central Register of Controlled Trials from 1980 to 2018 using title-abstract and full-text screening to identify original studies of the use of computerized tomography, magnetic resonance imaging, positron emission tomography, chest radiographs and serum tumor markers for the clinical staging of early stage testicular germ cell tumors. Read More

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http://dx.doi.org/10.1097/JU.0000000000000594DOI Listing
May 2020
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Magnetic Resonance Imaging to Differentiate the Histology of Testicular Masses: A Systematic Review of Studies With Pathologic Confirmation.

Urology 2020 Jan 1;135:4-10. Epub 2019 Oct 1.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD.

Ultrasound is the imaging modality of choice to evaluate scrotal pathology. However, differentiating malignant and benign testicular tumors is not always possible, and there is interest in evaluating magnetic resonance imaging (MRI) as a potential adjunct for diagnosis. We conducted a systematic review and found 9 studies related to MRI diagnosis of testicular masses. Read More

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http://dx.doi.org/10.1016/j.urology.2019.09.025DOI Listing
January 2020
3 Reads

Antitumor and antiangiogenic activity of the novel chimeric inhibitor animacroxam in testicular germ cell cancer.

Mol Oncol 2019 12 22;13(12):2679-2696. Epub 2019 Oct 22.

Corporate Member of Freie Universität Berlin, Berlin Institute of Health, Institute of Physiology, Humboldt-Universität zu Berlin, Charité - Universitätsmedizin Berlin, Germany.

Chimeric inhibitors, which merge two drug pharmacophores in a single molecule have become a prominent approach for the design of novel anticancer compounds. Here, we examined animacroxam, which combines histone deacetylase (HDAC) inhibitory and cytoskeleton-interfering pharmacophores, in testicular germ cell tumors (TGCT). The effectiveness of animacroxam was compared to that of the commonly applied chemotherapeutic cisplatin as well as the clinically approved HDAC inhibitor vorinostat. Read More

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http://dx.doi.org/10.1002/1878-0261.12582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887589PMC
December 2019

Testis Sparing Surgery of Small Testicular Masses: Retrospective Analysis of a Multicenter Cohort.

J Urol 2020 04 3;203(4):760-766. Epub 2019 Oct 3.

Sapienza University of Rome, Rome, Italy.

Purpose: We evaluated possible factors predicting testicular cancer in patients undergoing testis sparing surgery.

Materials And Methods: We retrospectively analyzed the records of all patients who underwent testis sparing surgery for a small testicular mass at a total of 5 centers. All patients with 1 solitary lesion 2 cm or less on preoperative ultrasound were enrolled in the study. Read More

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http://dx.doi.org/10.1097/JU.0000000000000579DOI Listing
April 2020
7 Reads

[Partial orchiectomy in testicular tumor: Surgical technique and role of intraoperatory ecography.]

Arch Esp Urol 2019 Oct;72(8):772-785

Servicio de Urología. Hospital Universitario Puerta de Hierro de Majadahonda. Madrid. España.

Objectives: Systematic review of the treatment of small testicular masses (STM) by testicular sparing surgery (TSS), including indications, surgical techniques and complications, as well as the correlation of the analysis of frozen sections (FSE) with the final tumor histology. As a secondary objective we report the initial experience of our center in TSS.

Material And Methods: A systematic literature search of the Medline/PubMed database for studies published until June 30, 2019 with the following keywords: "testis sparing surgery", "conservative surgery", "partial orquiectomy" "testicular neoplasms", "testis tumour", "Sex cord tumor", "intraoperative ultrasonography", "enucleation", "excision" or "resection" without time limits, in English and Spanish, identifying 20 articles with a total of 204 TSS, being the series with the largest sample size of 28. Read More

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October 2019
4 Reads

Imaging of Metastatic Germ Cell Tumors in Male Patients From Initial Diagnosis to Treatment-Related Toxicities: A Primer for Radiologists.

AJR Am J Roentgenol 2020 01 1;214(1):24-33. Epub 2019 Oct 1.

Department of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Ave, Boston, MA 02215.

This review describes the influence of histology and metastatic sites on prognosis in male patients with metastatic germ cell tumors (GCTs) and explains the role imaging in assessing therapeutic response, residual disease, recurrence, sand treatment-related toxicities. Seminomatous and nonseminomatous GCTs differ in imaging appearance, pattern of spread, and prognosis, and an organ-based approach is helpful in prognostication. Multimodality imaging aids in accurate staging, prognostication, characterization of treatment response, and identification of therapy-related toxicity. Read More

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http://dx.doi.org/10.2214/AJR.19.21623DOI Listing
January 2020
2 Reads

18F-Flourodeoxy glucose PET-computed tomography in testicular carcinoma: diagnostic and prognostic value.

Nucl Med Commun 2019 Dec;40(12):1268-1274

Departments of Nuclear Medicine.

Aim: This study aims to assess the diagnostic role of F-FDG PET/computed tomography in primary staging and restaging of testicular cancer in comparison with contrast-enhanced diagnostic thoracic-abdominopelvic computed tomography.

Material And Method: Thirty-two consecutive male patients with testicular carcinoma (median age: 29, min-max: 17-65) who were referred to the nuclear medicine department for F-FDG PET/computed tomography were retrospectively included in the study. Patients were evaluated based on the F-FDG PET/computed tomography indications and germ cell tumor subtypes. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001093DOI Listing
December 2019
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Testis-sparing Surgery for Pediatric Leydig Cell Tumors: Evidence of Favorable Outcomes Irrespective of Surgical Margins.

Urology 2019 Dec 24;134:203-208. Epub 2019 Sep 24.

Division of Urology, Department of Surgery, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: To review our single institution experience, exploring the role of testis-sparing surgical resection in a cohort of children with Testicular Leydig cell tumors (LCTs).

Materials And Methods: We reviewed all consecutive children presenting with testicular tumors between 2003 and 2017 (n = 66), excluding patients with alternative pathologies (n = 57). Subsequently data were collected on age at surgery, laterality, type of surgery, operative time, presenting symptoms, serum markers, imaging findings, frozen section, final pathology, and follow-up. Read More

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http://dx.doi.org/10.1016/j.urology.2019.09.016DOI Listing
December 2019
1 Read