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J Radiol Case Rep 2022 Jan 1;16(1):14-21. Epub 2022 Jan 1.

The Institute of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Inflammatory Myofibroblastic Tumors (IMTs) are rare fibroblastic/myofibroblastic neoplasms that affect predominately pediatric patients and young adults. Almost half of the patients with IMTs have a chromosomal abnormality in the Anaplastic Lymphoma Kinase 1 gene on chromosome 2p23. Although these tumors occur primarily in the lung, lesions have been reported in a variety of intra-abdominal organs like the liver, spleen, and mesentery. Read More

BMJ Case Rep 2022 May 18;15(5). Epub 2022 May 18.

Department of Medical Biotechnologies, University of Siena, Siena, Italy.

Extranodal non-Hodgkin's lymphomas of the gastrointestinal tract represent 30%-40% of all extranodal lymphomas. Gastric lymphomas are increasingly described in the literature due to the development of diagnostic techniques and the increased incidence, together with the reduced incidence of gastric solid neoplasms. Significant diagnostic difficulties are determined by the non-specificity of the symptoms, which are mostly chronic, characterised by a slow progression. Read More

Int J Surg Case Rep 2022 May 14;95:107180. Epub 2022 May 14.

Department of Pathology, Medical School, Fasa University of Medical Sciences, Fasa, Iran. Electronic address:

Introduction: Myxomas are rare benign mesenchymal neoplasms and mostly occur in cardiac atrium and with lower prevalence, appear in sinonasal tract, gnathic bone, skin and joints. Benign primary tumors of the small intestine are quite unusual accounting about 3% of all the gastrointestinal tract neoplasms.

Presentation Of Case: In this report, we present a rare case of small intestinal myxoma in a 43-year-old man complicated by ileoileal intussusception causing bowel obstruction. Read More

J Comput Assist Tomogr 2022 May-Jun 01;46(3):333-343. Epub 2022 Mar 4.

From the Department of Abdominal Radiology, University of Texas MD Anderson Cancer Center, Houston, TX.

Background: Routine computed tomography (CT) scans are thought to have poor performance for detection of gastrointestinal (GI) neuroendocrine neoplasms (NENs), which leads to delayed workup. Detection of even 1 bowel tumor can guide diagnostic workup and management. The purposes of this study were to assess the accuracy of multidetector computed tomography (MDCT) and to compare negative versus positive enteric contrast in detecting at least 1 GI tumor per patient with suspected or confirmed diagnosis of a NEN. Read More

Front Cell Infect Microbiol 2022 27;12:862211. Epub 2022 Apr 27.

Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.

 is a protozoan parasite causing diarrheal disease, giardiasis, after extracellular infection of humans and other mammals' intestinal epithelial cells (IECs) of the upper small intestine. The parasite has two main life cycle stages: replicative trophozoites and transmissive cysts. Differentiating parasites (encysting cells) and trophozoites have recently been shown to be present in the same regions of the upper small intestine, whereas most mature cysts are found further down in the intestinal system. Read More

Zhonghua Yi Xue Za Zhi 2022 May;102(18):1351-1358

Department of Radiology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.

The magnetic resonance imaging (MRI) features of intestinal-type periampullary carcinoma (IPAC) and pancreatobiliary-type periampullary carcinoma (PPAC) were compared and analyzed to discuss the optimal diagnosis scheme. Preoperative MRI images of 59 patients (32 males, 27 females, aged 37-80 years) diagnosed with periampullary carcinoma (PAC) confirmed by surgery and pathology in Nanjing Drum Tower Hospital from January 2017 to July 2020 were retrospectively analyzed. The patients were divided into 21 cases in the IPAC group (11 males, 10 females) and 38 cases in the PPAC group (21 males, 17 females) according to histopathological results. Read More

Nihon Shokakibyo Gakkai Zasshi 2022 ;119(5):452-458

Department of Gastroenterology, Yamagata City Hospital Saiseikan.

Intraductal papillary mucinous carcinoma (IPMC) arising from the heterotopic pancreas is rare. A case of IPMC metastasis from the jejunal heterotopic pancreas was described. The heterotopic pancreas could be the source of the submucosal tumor-like lesion found in the small intestine with an elevated carbohydrate antigen (CA) 19-9 level. Read More

Nihon Shokakibyo Gakkai Zasshi 2022 ;119(5):446-451

Department of Gastroenterology and Hepatology, Okayama University Hospital.

At the time of colon polyp follow-up, a 46-year-old Japanese woman with a history of invagination, colon polyps, cervical cancer, and breast cancer was suspected of Peutz-Jeghers syndrome and referred. Multiple polyposes of the jejunum were discovered by capsule endoscopy and double-balloon endoscopy, and the resected specimen was diagnosed with hamartoma. During the follow-up, advanced pancreatic cancer-derived from IPMN developed. Read More

BMC Gastroenterol 2022 May 9;22(1):226. Epub 2022 May 9.

Department of Hepatobiliary Surgery, Dongyang People's Hospital, Zhejiang Province, Jinhua, 322100, China.

Background: Primary duodenal cancer (PDC) is rare, especially signet-ring cell carcinoma (SRCC) of the duodenal bulb, and it is commonly misdiagnosed as an ulceration. Here, we report a rare case of SRCC of the duodenal bulb presenting with gastrointestinal hemorrhage in an 82-year-old man.

Case Presentation: An 82-year-old man was admitted for gastrointestinal hemorrhage. Read More

Medicine (Baltimore) 2022 Apr 29;101(17):e29225. Epub 2022 Apr 29.

Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Republic of Korea.

Rationale: Transvaginal evisceration of the small bowel is an extremely rare condition after hysterectomy, which requires urgent surgical intervention to prevent serious bowel morbidity and mortality.

Patient Concerns: A 65-year-old woman presented with sudden-onset severe abdominal pain and a mass protruding through the vagina. The past surgical history was significant, with an abdominal hysterectomy for cervical cancer performed 11 weeks prior to presentation. Read More

Acta Med Okayama 2022 Apr;76(2):155-165

Department of Urology, Kochi Health Sciences Center.

Small bowel metastasis from renal cell carcinoma (RCC) is rare, and its clinicopathological characteristics are unclear; thus, we revisited the concept of this tumor and reviewed its diagnostic and treatment modalities. We filtered MEDLINE searches of articles published in English between 1950 and 2019, and identified 100 patients who had undergone treatment, including 1 patient from our clinic. We extracted patient characteristics, treatment, and prognostic data, resulting in clinicopathological data on 100 patients (83 men, 17 women). Read More

Rinsho Ketsueki 2022 ;63(4):254-259

Department of Hematology, Sasebo City General Hospital.

In about half of the cases, autoimmune hemolytic anemia (AIHA) is secondary to an underlying disease, often due to paraneoplastic syndromes. Recently, the number of patients developing metachronous multiple primary malignant tumors (MPMTs) has been increasing due to the aging of the population and the longer survival times of those with malignant tumors. A 78-year-old woman was diagnosed with sigmoid colon cancer in May 2017 and with warm AIHA in October 2017. Read More

J Med Case Rep 2022 May 1;16(1):174. Epub 2022 May 1.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Neurofibromatosis type 1 is an inherited cancer predisposition syndrome that is caused by a mutation in the NF1 gene that encodes neurofibromin. Patients with neurofibromatosis type 1 have a higher risk of gastrointestinal stromal tumor. This study reports the case of a patient with gastrointestinal stromal tumor who was later diagnosed to have neurofibromatosis type 1 and, unlike usual features, had some uncommon features such as occurrence at an early age and unusual site of origin. Read More

J Ovarian Res 2022 Apr 27;15(1):47. Epub 2022 Apr 27.

Department of Pathology, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530021, PR China.

Background: Primary ovarian lymphoma has been difficult to diagnose clinically and pathologically due to its rare incidence and non-specific clinical symptoms.

Case Presentation: A 75-year-old female patient was reported in this study. The patient had a six-month history of changes in bowel habits, with occasional black feces and paroxysmal pain in the abdomen. Read More

Eur J Cancer 2022 Jun 23;168:80-90. Epub 2022 Apr 23.

Asklepios Kliniken Hamburg, Department of Internal Medicine and Gastroenterology, Hamburg, Germany. Electronic address:

Background: Neuroendocrine neoplasms (NENs) are rare tumours with variable clinical behaviour. Their natural history is ideally best approached in large, multicentre and multinational registries with long-term patients' follow-up. The European Neuroendocrine Tumour Society registry aims to obtain information regarding NEN outcomes and prognostic factors in a European frame. Read More

Rev Esp Enferm Dig 2022 Apr 26. Epub 2022 Apr 26.

Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, España.

A 71-year-old woman diagnosed with type II diabetes mellitus with severe iron deficiency anemia and positive fecal occult blood. Colonoscopy was performed, showing a soft mass (figure A) in the ascending colon, with biopsies compatible with plasmacytoma and restriction for Kappa light chains (figure C and D). After bone marrow aspiration, associated IgG multiple myeloma was detected, so chemotherapy with VMP (Bortezomib, Melphalan and Prednisone) was started. Read More

Hinyokika Kiyo 2022 Mar;68(3):87-90

The Department of Urology, The Jikei University School of Medicine.

A 67-year-old man presented with gross hematuria. The patient underwent laparoscopic radical prostatectomy for localized prostate cancer 8 years ago. Metachronous bladder cancer (pT1, high-grade and pTis) was diagnosed by transurethral resection. Read More

J Med Invest 2022 ;69(1.2):19-24

Department of Community Medicine and Medical Science, Tokushima University Graduate School of Biomedical Sciences. 3-18-15, Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.

Small bowel neoplasms are rare and account for 3-6% of all gastrointestinal neoplasms. For the diagnosis of small bowel neoplasms, differentiating normal bowel tissue from tumor is critical and depends on imaging modality and scanning techniques. The detection and characterization of small bowel neoplasms have recently improved with the advance of computed tomography (CT) technology. Read More

Radiographics 2022 May-Jun;42(3):759-777. Epub 2022 Apr 22.

From the Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (M.I., V.M.M.); Department of Radiology, University of Louisville, Louisville, Ky (N.K.); Department of Radiology, VA Medical Center, Fayetteville, NC (A.R.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (M.G.L.); Department of Radiology, Division of Abdominal Imaging, University of Pittsburgh Medical Center, Pittsburgh, Pa (A.K.D.); Department of Radiology, University of Texas Health at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 (L.K., V.S.K.); and Department of Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (S.R.P.).

There is a wide spectrum of hereditary and acquired immunodeficiency disorders that are characterized by specific abnormalities involving a plethora of humoral, cellular, and phagocytic immunologic pathways. These include distinctive primary immunodeficiency syndromes due to characteristic genetic defects and secondary immunodeficiency syndromes, such as AIDS from HIV infection and therapy-related immunosuppression in patients with cancers or a solid organ or stem cell transplant. The gut mucosa and gut-associated lymphoid tissue (the largest lymphoid organ in the body), along with diverse commensal microbiota, play complex and critical roles in development and modulation of the immune system. Read More

Cureus 2022 Mar 18;14(3):e23302. Epub 2022 Mar 18.

Internal Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Port Jefferson, USA.

Neuroendocrine neoplasms (NENs) are epithelial neoplasms with predominant neuroendocrine differentiation that arise in the gastrointestinal tract, unique to the site of origin, such as the pancreas and small intestine. Neuroendocrine breast carcinoma (NEBC) is a rare tumor. Diagnosing NEBC is challenging because there is no specific clinical presentation, as it is usually presented as a breast lump. Read More

Indian J Pathol Microbiol 2022 Apr-Jun;65(2):480-481

Speciality Laboratory for Histopathology, Cytology and Immunohistochemistry, Dhantoli, Nagpur, Maharashtra, India.

J Neuroendocrinol 2022 Mar 14:e13117. Epub 2022 Mar 14.

Reims Medical School, University of Champagne Ardennes, Reims, France.

Complete surgical resection is the only hope to cure small intestine neuroendocrine neoplasms (SiNENs). However, inadequate lymphadenectomy or entire small bowel palpation for multiple primary tumours renders at least 20% of resections suboptimal. This study was undertaken to investigate reintervention outcomes after initial suboptimal resections (ISORs), and agreement between residual tumour identification on interval imaging and during reintervention. Read More

World J Gastroenterol 2022 Mar;28(10):985-1008

Department of Gastroenterology, St. Luke's International Hospital, Chuo-ku 104-8560, Tokyo, Japan.

Malignant biliary obstruction generally results from primary malignancies of the pancreatic head, bile duct, gallbladder, liver, and ampulla of Vater. Metastatic lesions from other primaries to these organs or nearby lymph nodes are rarer causes of biliary obstruction. The most common primaries include renal cancer, lung cancer, gastric cancer, colorectal cancer, breast cancer, lymphoma, and melanoma. Read More

Cell Mol Life Sci 2022 Apr 16;79(5):243. Epub 2022 Apr 16.

Department of Medical Chemistry, University of Debrecen, Egyetem tér 1., Debrecen, 4032, Hungary.

Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile acid synthesis takes place in the liver yielding primary bile acids; however, other tissues have also the capacity to generate bile acids (e.g. Read More

J Am Coll Surg 2022 May;234(5):900-909

Division of Endocrine and Oncologic Surgery, Department of Surgery (Fraker, Miura, Karakousis), Hospital of the University of Pennsylvania, Philadelphia, PA.

Background: The incidence of, and factors associated with, lymph node metastasis (LN+) in non-functional gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are not well characterized.

Methods: Patients were identified from the 2010-2015 National Cancer Database who underwent surgical resection with lymphadenectomy for clinical stage I-III non-functional GEP NETs. Among a randomly selected training subset of 75% of the study population, variables associated with LN+ were identified using multivariable logistic regression analysis, and these variables were used to create a risk-score model for LN+, which was internally validated among the remaining 25% of the cohort. Read More

J Cancer Prev 2022 Mar;27(1):50-57

Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, WI, USA.

Administration of black raspberries (BRBs) and their anthocyanin metabolites, including protocatechuic acid (PCA), has been demonstrated to exert chemopreventive effects against colorectal cancer through alteration of innate immune cell trafficking, modulation of metabolic and inflammatory pathways, etc. Previous research has shown that the gut microbiome is important in the effectiveness of chemoprevention of colorectal cancer. This study aimed to assess the potency of PCA versus BRB dietary administration for colorectal cancer prevention using an mouse model and determine how bacterial profiles change in response to PCA and BRBs. Read More

Eur J Case Rep Intern Med 2022 14;9(3):003231. Epub 2022 Mar 14.

Internal Medicine Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.

Small bowel tumours are rare, representing about 0.5% of all tumours and about 3% of gastrointestinal tract tumours. The low prevalence contrasts with the vast surface area of the small intestine, which accounts for over 90% of the surface area of the digestive tract. Read More

Nihon Shokakibyo Gakkai Zasshi 2022 ;119(4):342-350

Department of Pathology, Ageo Central General Hospital.

During a medical health check, a 29-year-old man was presented to our hospital with iron deficiency anemia. He had no significant medical history in his family. Despite being diagnosed with ocular sarcoidosis 5 years ago, he had no vision problems. Read More

Sci Rep 2022 04 6;12(1):5774. Epub 2022 Apr 6.

Surgical Oncology Program, National Cancer Institute, 9000 Rockville Pike Building 10, Room 4-3760, Bethesda, MD, 20892, USA.

Wild-type KIT and PDGFRA gastrointestinal stromal tumors (GIST) are rare tumors with limited treatment options. We sought to determine the clinicopathologic features of wild-type GIST and identify factors that influence overall survival (OS) using a large national database. Retrospective evaluation of patients with wild-type GIST in the National Cancer Database (NCDB) was performed. Read More

BMC Womens Health 2022 Apr 6;22(1):104. Epub 2022 Apr 6.

Division of Gynaecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, S. Orsola Hospital, University of Bologna, Via Massarenti 13, 40138, Bologna, Italy.

Background: Malignant epithelioid neoplasm with ACTB-GLI1 fusion are considered different from the more common pericytic lesions, such myopericytoma, because they have a spectrum of different genetic abnormalities. They appear to pursue a benign clinical course in young adults, although in sporadic cases lymph node metastasis were described. The categorization of this new type of tumor may also lead to new therapeutic strategies, because they might be sensitive to SHH pathway inhibitors. Read More