1,645 results match your criteria Malignant Nasopharyngeal Tumors


High SRC-1 and Twist1 expression predicts poor prognosis and promotes migration and invasion by inducing epithelial-mesenchymal transition in human nasopharyngeal carcinoma.

PLoS One 2019 11;14(4):e0215299. Epub 2019 Apr 11.

Department of Otorhinolaryngology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.

Steroid receptor coactivator 1 (Src-1) and Twist1 are aberrantly upregulated in a variety of tumors and play an important role in tumor progression. However, the exact role of Src-1 and Twist1 in nasopharyngeal carcinoma (NPC) is uncertain. In this study, we investigated the possible prognostic value and biological effect of Src-1 and Twist1 in NPC. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215299PLOS
April 2019
3.234 Impact Factor

A unique case of eyelid metastasis from chondroid chordoma.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):287-289

Department of Pathology, The First Affiliated Hospital of Zhengzhou University; Department of Pathology, Basic Medicine College of Zhengzhou University, Zhengzhou, China.

A unique case of eyelid metastasis from nasopharyngeal chondroid chordoma in a 63-year-old woman was reported. Chordomas are rare tumors of the bone deriving from remnants of the embryonic notochord. Histologically, the tumor showed lobulated structure and concludes two types of cells: liquid drop cell and small round/cubic cell. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_387_18DOI Listing
April 2019
1 Read

VPS33B interacts with NESG1 to modulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling and induce 5-fluorouracil sensitivity in nasopharyngeal carcinoma.

Cell Death Dis 2019 Apr 3;10(4):305. Epub 2019 Apr 3.

Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, 510310, Guangzhou, Guangdong, P. R. China.

The vacuolar protein sorting 33B (VPS33B) was rarely reported in malignant tumors. In this research, we demonstrated that overexpression of VPS33B inhibited proliferation and chemoresistance to fluorouracil (5-FU) in nasopharyngeal carcinoma (NPC) in vivo and in vitro. Mechanistic analysis confirmed that overexpression of VPS33B modulated EGFR/PI3K/AKT/c-Myc/P53 signaling to arrest the cell cycle at G1/S phase. Read More

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http://www.nature.com/articles/s41419-019-1457-9
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http://dx.doi.org/10.1038/s41419-019-1457-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447525PMC
April 2019
4 Reads

PNUTS mediates ionizing radiation-induced CNE-2 nasopharyngeal carcinoma cell migration, invasion, and epithelial-mesenchymal transition via the PI3K/AKT signaling pathway.

Onco Targets Ther 2019 15;12:1205-1214. Epub 2019 Feb 15.

Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China,

Purpose: Ionizing radiation (IR) is widely used for treating nasopharyngeal carcinoma (NPC). However, recent studies indicate that IR can also promote the migration and invasion of malignant tumors. Phosphatase 1 nuclear-targeting subunit (PNUTS), a novel interacting protein, was recently demonstrated to be involved in tumorigenesis and metastasis formation. Read More

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http://dx.doi.org/10.2147/OTT.S188571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388972PMC
February 2019
1 Read

Long noncoding RNA DANCR promotes nasopharyngeal carcinoma progression by interacting with STAT3, enhancing IL-6/JAK1/STAT3 signaling.

Biomed Pharmacother 2019 May 5;113:108713. Epub 2019 Mar 5.

Department of Otorhinolaryngology, China Medical University Affiliated ShengJing Hospital, Shenyang City, Liaoning Province, China. Electronic address:

Nasopharyngeal carcinoma (NPC) is the most common type of malignancy of the neck and head in Southeast Asia and North Africa. Long noncoding RNA (LncRNA) Differentiation antagonizing nonprotein coding RNA (DANCR) has been reported to exert oncogenic functions in various malignant tumors. However, whether DANCR is involved in NPC tumorgenesis and its underlying mechanisms are still unknown. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108713DOI Listing
May 2019
2.023 Impact Factor

Cervical nodal metastasis after malignant conversion of sinonasal inverted papilloma: Report of a rare case and literature review.

Oral Oncol 2019 Mar 1;90:45-47. Epub 2019 Feb 1.

Augusta University, Department of Otolaryngology-Head and Neck Surgery, Augusta, GA 30912, United States.

Malignant conversion of sinonasal inverted papilloma (SNIP) occurs in approximately ten percent of cases. These tumors are classically described as locally destructive, but without metastatic potential. Only four cases of malignant conversion with cervical nodal metastases have been described in the English literature. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.024DOI Listing
March 2019
1 Read

Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14223

Department of Radiology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.

Rationale: Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms with only a few reported cases affecting the nasal cavity, paranasal sinuses, and anterior skull base.

Patient Concerns: A 12-year-old girl with a mass in her nose was admitted to the Department of Otorhinolaryngology of Shenzhen Children's Hospital. She had a 4-month history of progressive, unilateral right nasal obstruction, unilateral mucopurulent rhinorrhea, foul nasal odor, snoring, hyposmia, occasional epistaxis, and no headache, no facial numbness, without eye swelling and vision loss. Read More

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http://dx.doi.org/10.1097/MD.0000000000014223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358413PMC
January 2019
9 Reads
5.723 Impact Factor

Loss of atypical chemokine receptor 4 facilitates C-C motif chemokine ligand 21-mediated tumor growth and invasion in nasopharyngeal carcinoma.

Exp Ther Med 2019 Jan 23;17(1):613-620. Epub 2018 Nov 23.

Department of Radiotherapy, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan 650000, P.R. China.

Nasopharyngeal carcinoma (NPC) is a common malignant disease that is prevalent in Asian countries. Atypical chemokine receptor 4 (ACKR4) binds to various chemokines, including C-C motif chemokine ligand (CCL)19, CCL21, CCL25 and C-X-C motif chemokine ligand 13, without inducing downstream signaling transduction. However, the role of ACKR4 in modulating NPC development remains unclear. Read More

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http://dx.doi.org/10.3892/etm.2018.7007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307432PMC
January 2019

Predictive value of pretreatment MRI texture analysis in patients with primary nasopharyngeal carcinoma.

Eur Radiol 2019 Jan 7. Epub 2019 Jan 7.

Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou, 510120, People's Republic of China.

Objectives: To determine the predictive value of pretreatment MRI texture analysis for progression-free survival (PFS) in patients with primary nasopharyngeal carcinoma (NPC).

Methods: Ethical approval by the institutional review board was obtained for this retrospective analysis. In 79 patients with primary NPC, texture analysis of the primary tumour was performed on pretreatment T2 and contrast-enhanced T1-weighted images (T2WIs and CE-T1WIs). Read More

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http://dx.doi.org/10.1007/s00330-018-5961-6DOI Listing
January 2019
2 Reads

lncRNA CASC2/miR‑18a‑5p axis regulates the malignant potential of nasopharyngeal carcinoma by targeting RBBP8.

Oncol Rep 2019 Mar 19;41(3):1797-1806. Epub 2018 Dec 19.

Department of Otolaryngology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China.

Nasopharyngeal carcinoma (NPC) is a prevalent head and neck tumor which has a high mortality rate in Southeast Asia, especially in Southern China. Cancer susceptibility candidate 2 (CASC2) is a newly identified long non‑coding RNA (lncRNA) that has been found to play a suppressive role in several types of tumors. However, the expression and functional role of CASC2 in NPC are still unclear. Read More

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http://dx.doi.org/10.3892/or.2018.6941DOI Listing
March 2019
6 Reads

EBV-miR-BART1-5P activates AMPK/mTOR/HIF1 pathway via a PTEN independent manner to promote glycolysis and angiogenesis in nasopharyngeal carcinoma.

PLoS Pathog 2018 12 17;14(12):e1007484. Epub 2018 Dec 17.

Shenzhen Key Laboratory of Viral Oncology, the Clinical Innovation & Research Center (CIRC), Shenzhen Hospital, Southern Medical University, Shenzhen, China.

Abnormal metabolism and uncontrolled angiogenesis are two important characteristics of malignant tumors. The occurrence of both events involves many key molecular changes including miRNA. However, EBV encoded miRNAs are rarely mentioned as capable of regulating tumor metabolism and tumor angiogenesis. Read More

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http://dx.plos.org/10.1371/journal.ppat.1007484
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http://dx.doi.org/10.1371/journal.ppat.1007484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312352PMC
December 2018
18 Reads

Fibronectin promotes nasopharyngeal cancer cell motility and proliferation.

Biomed Pharmacother 2019 Jan 26;109:1772-1784. Epub 2018 Nov 26.

Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Nasopharyngeal cancer (NPC) is an Epstein-Barr virus (EBV)-associated carcinoma. Fibronectin is regarded as a prognosticator in NPC and its involvement in cell motility has been reported in EBV infection and viral latent membrane protein 1 (LMP1) overexpression NPC cell lines. However, its malignant potential in NPC cell lines without harbouring the EBV genome has not been investigated. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.11.055DOI Listing
January 2019

CD38 affects the biological behavior and energy metabolism of nasopharyngeal carcinoma cells.

Int J Oncol 2019 Feb 3;54(2):585-599. Epub 2018 Dec 3.

Department of Oncology, Hunan Provincial Tumor Hospital, Xiangya School of Medicine, Central South University, Changsha, Hunan 410006, P.R. China.

Nasopharyngeal carcinoma (NPC) is the most common malignant tumor type in Southern China and South‑East Asia. Cluster of differentiation (CD)38 is highly expressed in the human immune system and participates in the activation of T, natural killer and plasma cells mediated by CD2 and CD3 through synergistic action. CD38 is a type II transmembrane glycoprotein, which was observed to mediate diverse activities, including signal transduction, cell adhesion and cyclic ADP‑ribose synthesis. Read More

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http://dx.doi.org/10.3892/ijo.2018.4651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317656PMC
February 2019
7 Reads

Association Between Pretreatment Serum Apolipoprotein A1 and Prognosis of Solid Tumors in Chinese Population: A Systematic Review and Meta-Analysis.

Cell Physiol Biochem 2018 22;51(2):575-588. Epub 2018 Nov 22.

Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an,

Background/aims: Serum apolipoprotein A1 (apoA1) has been reported to be abnormally expressed in several malignancies. However, the prognostic role of apoA1 in solid tumors is still controversial. We conducted this meta-analysis to obtain a more accurate evaluation of prognostic significance of apoA1 in Chinese patients with solid tumors. Read More

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http://dx.doi.org/10.1159/000495277DOI Listing
December 2018
9 Reads

Molecular mechanisms of EBV-driven cell cycle progression and oncogenesis.

Med Microbiol Immunol 2018 Nov 1. Epub 2018 Nov 1.

Medical School, Cancer Research Institute, Key Laboratory of Tumor Cellular and Molecular Pathology of Hunan Province, University of South China, Chang Sheng Xi Avenue 28, Hengyang, 421001, Hunan, People's Republic of China.

The early stage of oncogenesis is linked to the disorder of the cell cycle. Abnormal gene expression often leads to cell cycle disorders, resulting in malignant transformation of human cells. Epstein-Barr virus (EBV) is associated with a diverse range of human neoplasms, such as malignant lymphoma, nasopharyngeal carcinoma and gastric cancer. Read More

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http://link.springer.com/10.1007/s00430-018-0570-1
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http://dx.doi.org/10.1007/s00430-018-0570-1DOI Listing
November 2018
13 Reads

Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies.

Cancer Commun (Lond) 2018 09 25;38(1):59. Epub 2018 Sep 25.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, 510060, P. R. China.

Background: Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperplasia, the positive rate for malignancy identification during biopsy is low, thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt. Here, we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.

Methods: An endoscopic images-based nasopharyngeal malignancy detection model (eNPM-DM) consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation. Read More

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http://dx.doi.org/10.1186/s40880-018-0325-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156962PMC
September 2018
7 Reads

Combined effects of Lenvatinib and iodine-131 on cell apoptosis in nasopharyngeal carcinoma through inducing endoplasmic reticulum stress.

Exp Ther Med 2018 Oct 23;16(4):3325-3332. Epub 2018 Aug 23.

Department of Nuclear Medicine, The Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, P.R. China.

Nasopharyngeal carcinoma (NPC) is a type of malignant tumor characterized by high invasiveness, metastatic potential and worldwide incidence among patients with head and neck cancer. It has previously been demonstrated that Lenvatinib (LEB) is an efficient anti-cancer agent by multi-targeting of tyrosine kinase inhibitors. Iodine-131 (I-131) therapy has been accepted for the treatment of thyroid cancer and other carcinomas. Read More

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http://dx.doi.org/10.3892/etm.2018.6652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143866PMC
October 2018
2 Reads

Predictive Value of [F]ML-10 PET/CT in Early Response Evaluation of Combination Radiotherapy with Cetuximab on Nasopharyngeal Carcinoma.

Mol Imaging Biol 2018 Sep 14. Epub 2018 Sep 14.

Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, No. 270, Dong'an Road, Xuhui District, Shanghai, China.

Purpose: Apoptosis may be an indication of success therapy, and precise detection of apoptosis can provide instructional suggestions in the therapy management of malignant tumors.

Procedures: We used CNE-1 cell lines for in vitro experiments, and colony formation assay, CCK-8 assay, cell apoptosis analysis, and western blotting were performed. For in vivo experiments, subcutaneous xenotransplanted tumor models of CNE-1 in nude mice were established. Read More

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http://dx.doi.org/10.1007/s11307-018-1277-9DOI Listing
September 2018
2 Reads
2.774 Impact Factor

The role of long non-coding RNA AFAP1-AS1 in human malignant tumors.

Pathol Res Pract 2018 Oct 20;214(10):1524-1531. Epub 2018 Aug 20.

Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, PR China. Electronic address:

Objectives: Long non-coding RNAs (lncRNAs) are a type Table of endogenous RNA longer than 200 nucleotides in length, and this kind of RNAs lack or possess limited ability of coding proteins. A large number of studies have demonstrated that lncRNAs could take part in massive biological processes, such as transcriptional activation and interference, cellular differentiation, proliferation, migration, invasion and apoptosis. The abnormal expression of lncRNAs has been clarified to play extremely important roles in various diseases, especially in human cancers. Read More

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http://dx.doi.org/10.1016/j.prp.2018.08.014DOI Listing
October 2018
20 Reads
1.562 Impact Factor

Hyponatremia is a potential predictor of progression in radiation-induced brain necrosis: a retrospective study.

BMC Neurol 2018 Aug 29;18(1):130. Epub 2018 Aug 29.

Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, No. 107 West Yanjiang Road, Guangzhou, 510120, China.

Background: To investigate the prognostic value of hyponatremia, defined as serum sodium level < 135 mEq/L, in radiation-induced brain necrosis (RN) patients.

Methods: We performed a retrospective analysis of the RN patients (The patients included in our study had a history of primary cancers including nasopharyngeal carcinoma/glioma/oral cancer and received radiotherapy previously and then were diagnosed with RN) treated in Sun yat-sen Memorial Hospital from January 2013 to August 2015. Patients without cranial magnetic resonance imaging (MRI) scan and serum sodium data were excluded. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-018-1135-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114772PMC
August 2018
16 Reads

[Analysis of clinical characteristics and prognosis of neuromyelitis optic spectrum disease complicated with malignant tumor].

Zhonghua Yi Xue Za Zhi 2018 Aug;98(31):2496-2500

Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

To investigate the clinical features of patients involved with both malignant tumors and neuromyelitis optica spectrum disorders (NMOSD). The clinical data of 473 patients with NMOSD admitted into the Third Affiliated Hospital of Sun Yat-sen University and the Department of Neurology, Affiliated Hospital of Guizhou Medical University from June 2012 to March 2017 were retrospectively analyzed. Eleven NMOSD patients complicated with malignant tumors were screened out (3 with breast cancer, 2 with cervical cancer, 2 with rectal cancer, 2 with leukemia, 1 with nasopharyngeal carcinoma, 1 with thyroid cancer). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.31.009DOI Listing
August 2018
8 Reads

The Pinx1 Gene Downregulates Telomerase and Inhibits Proliferation of CD133+ Cancer Stem Cells Isolated from a Nasopharyngeal Carcinoma Cell Line by Regulating Trfs and Mad1/C-Myc/p53 Pathways.

Cell Physiol Biochem 2018 23;49(1):282-294. Epub 2018 Aug 23.

Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Background/aims: Cancer stem cells (CSCs) are important factors for the continuous growth, recurrence, and metastasis of malignant tumors. They are responsible for the ineffectiveness of traditional radiotherapy and chemotherapy toward malignant tumors. Currently, stem cells or side-population cells have been isolated from many cancer cell lines and malignant tumor tissues, including nasopharyngeal carcinoma. Read More

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http://dx.doi.org/10.1159/000492878DOI Listing
September 2018
4 Reads

The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma.

J Cancer 2018 30;9(16):2852-2864. Epub 2018 Jul 30.

Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

Epstein-Barr virus (EBV) is an oncogenic herpes virus that is closely associated with the initiation and development of nasopharyngeal carcinoma (NPC), lymphoma and other malignant tumors. EBV encodes 44 mature miRNAs that regulate viral and host cell gene expression and plays a variety of roles in biological functions and the development of cancer. In this review, we summarized the biological functions and molecular mechanisms of Epstein-Barr virus-encoded microRNAs (EBV miRNAs) in tumor immune evasion, proliferation, anti-apoptosis, invasion, metastasis and as a potential biomarker for NPC diagnosis and prognosis. Read More

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http://dx.doi.org/10.7150/jca.25460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096363PMC
July 2018
20 Reads

[Clinicopathologic features of nasopharyngeal papillary adenocarcinoma].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Aug;53(8):621-623

Department of Pathology, Henan Provincial People's Hospital, Zhengzhou 450003, China.

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2018.08.012DOI Listing

Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.

Front Oncol 2018 2;8:265. Epub 2018 Aug 2.

Biomedical Science Department, College of Health Sciences, Qatar University, Doha, Qatar.

The Epstein-Barr virus (EBV) is the first herpesvirus identified to be associated with human cancers known to infect the majority of the world population. EBV-associated malignancies are associated with a latent form of infection, and several of the EBV-encoded latent proteins are known to mediate cellular transformation. These include six nuclear antigens and three latent membrane proteins (LMPs). Read More

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https://www.frontiersin.org/article/10.3389/fonc.2018.00265/
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http://dx.doi.org/10.3389/fonc.2018.00265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082928PMC
August 2018
14 Reads

The epidemiology, treatment, and determinants of outcome of primary head and neck cancers at the Jos University Teaching Hospital.

South Asian J Cancer 2018 Jul-Sep;7(3):183-187

Department of Otorhinolaryngology, Head and Neck Surgery, Jos University Teaching Hospital, Jos, Nigeria.

Introduction: This study aims to evaluate the epidemiology, treatment, and factors that determine the outcomes of head and neck cancers (HNC).

Patients And Methods: Retrospective analytical review of HNC managed at the Jos University Teaching Hospital between May 2007 and April 2017 using the International Classification of Diseases version 10.

Results: Of 487 head and neck neoplasms, 129 (26. Read More

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http://dx.doi.org/10.4103/sajc.sajc_15_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069340PMC
August 2018
10 Reads

A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection.

PLoS Pathog 2018 07 27;14(7):e1007179. Epub 2018 Jul 27.

Department of Oncology in Wisconsin Institutes for Medical Research, McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America.

Latent Epstein-Barr virus (EBV) infection contributes to both B-cell and epithelial-cell malignancies. However, whether lytic EBV infection also contributes to tumors is unclear, although the association between malaria infection and Burkitt lymphomas (BLs) may involve excessive lytic EBV replication. A particular variant of the viral promoter (Zp) that controls lytic EBV reactivation is over-represented, relative to its frequency in non-malignant tissue, in EBV-positive nasopharyngeal carcinomas and AIDS-related lymphomas. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082571PMC
July 2018
4 Reads

[Clinical study of nasopharyngeal masses with suspicion of nasopharyngeal carcinoma in adult patients].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;53(7):519-523

Department of Otorhinolaryngology Head and Neck Surgery, PLA General Hospital, Beijing 100853, China.

To improve the accuracy of diagnosis and to reduce the misdiagnosis rate of nasopharyngeal carcinoma by analyzing the characteristics of such masses. Clinical data from 55 patients with suspicion of nasopharyngeal carcinoma diagnosed and treated between March 2016 and September 2017 were analyzed. All patients were followed up regularly. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2018.07.007DOI Listing
July 2018
8 Reads

Infratemporal fossa tumors: When to suspect a malignant tumor? A retrospective cohort study of 62 cases.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Oct 10;135(5):311-314. Epub 2018 Jul 10.

Head and Neck Department, Lariboisière Hospital, University Paris 7, 2, rue Amboise-Paré, 75010 Paris, France.

Objectives: Infratemporal fossa (ITF) tumors are rare and little is known about their general epidemiology, making it sometimes difficult for clinicians, who seldom encounter them, to distinguish between benign and malignant forms on the basis of the initial clinical and radiological work-up alone. The objectives of this retrospective study were: (i) to determine the respective prevalences of the various histologic types of ITF tumor, and (ii) to assess associations between certain clinical and radiological features and malignancy.

Methods: A single-center observational study in a university hospital included all new consecutive cases of ITF tumor treated from January 2000 to December 2016. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.06.005DOI Listing
October 2018
1 Read

[Effect of A20 gene induced silencing on the biological behaviors of human nasopharyngeal carcinoma cell].

Zhonghua Yi Xue Za Zhi 2018 Jun;98(24):1956-1961

Department of Pathology, Shenzhen Baoan Hospital Affiliated to Southern Medical University, Shenzhen 518101, China.

To observe the effect of knockdown A20 gene expression on the proliferation, invasion and metastasis of human nasopharyngeal carcinoma cell and . Human nasopharyngeal carcinoma cell 5-8F-H3 was transfected with A20-specific shRNA Tet-on inducible plasmid vectors, and A20 silenced cells were screened by Puromycin. Quantitative RT-PCR and Western blot analysis were used to detect the mRNA level and protein of A20. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.24.013DOI Listing
June 2018
8 Reads

Pros and Cons of the New Edition of TNM Classification of Head and Neck Squamous Cell Carcinoma.

Oncology 2018 5;95(4):202-210. Epub 2018 Jul 5.

The TNM classification is a worldwide standard staging system used to define the extent of cancer and is a major prognostic factor in predicting the outcome of patients. The TNM Classification of Malignant Tumours, 8th edition, has been used since January 1, 2018. In the area of head and neck cancer major modifications were produced: important updated T and N modification for oral cavity and nasopharyngeal cancer, the introduction of clinical and pathological stages for neck disease, and a new HPV-16-positive HNSCC classification. Read More

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http://dx.doi.org/10.1159/000490415DOI Listing
October 2018
1 Read

The detection and significance of T cells in nasopharyngeal carcinoma patients.

J Cancer Res Ther 2018 Jun;14(Supplement):S331-S335

Central Laboratory, Affiliated Hospital of Guiyang Medical College, Guiyang, China.

Aim Of Study: Nasopharyngeal carcinoma (NPC) is by far the most common malignant tumor of the nasopharynx and is suggested to be related to immune system dysfunction. T cells play a central role in the cell-mediated immunity. However, how the T cells vary during the NPC treatment is still unclear. Read More

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http://dx.doi.org/10.4103/0973-1482.235350DOI Listing
June 2018
18 Reads

Osteoradionecrosis of the Skull Base in Nasopharyngeal Carcinoma: Incidence and Risk Factors.

Int J Radiat Oncol Biol Phys 2018 Nov 28;102(3):552-555. Epub 2018 Jun 28.

Department of Otolaryngology-Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Purpose: Nasopharyngeal carcinoma (NPC) is a type of malignancy with a high prevalence in southern China and Southeast Asia. The primary treatment modality is radiation therapy (RT). Osteoradionecrosis (ORN) of the skull base remains one of the most serious complications after RT, affecting survival time and quality of life. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.06.027DOI Listing
November 2018
9 Reads

Undifferentiated sinonasal malignant melanoma: A case report.

Oncol Lett 2018 Jul 8;16(1):580-584. Epub 2018 May 8.

Department of Pathology, Anhui Provincial Hospital, Hefei, Anhui 230001, P.R. China.

Undifferentiated sinonasal malignant melanoma (MM) is a rare type of tumor, which can be easily misdiagnosed. The present study reports a 41-year-old male patient who presented with a 4-day history of epistaxis. Clinical examination and radiological imaging lead to the detection of a mass in the right sinonasal region. Read More

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http://dx.doi.org/10.3892/ol.2018.8662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006502PMC
July 2018
21 Reads

Berberine Hydrochloride-Loaded Chitosan Nanoparticles Effectively Targets and Suppresses Human Nasopharyngeal Carcinoma.

J Biomed Nanotechnol 2018 Aug;14(8):1486-1495

Nasopharyngeal carcinoma (NPC) is a common epithelial malignancy that occurs in the nasopharynx and it is one of the high incidences of malignant tumors in China. As previous reports, berberine hydrochloride (BH) possesses a repressive effect on the proliferation of various cancer types. But the application of BH was hampered for a long time due to its hydrophobic properties, along with poor stability and bioavailability. Read More

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http://dx.doi.org/10.1166/jbn.2018.2596DOI Listing
August 2018
13 Reads

Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma.

Oncol Rep 2018 Aug 14;40(2):1017-1025. Epub 2018 Jun 14.

Oncology Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China.

SETDB1, an H3K9‑specific histone methyltransferase, has been described as a repressed transcription marker which triggers tumorigenesis of many types of human cancer. However, there are few studies elucidating the relationship between SETDB1 and nasopharyngeal carcinoma. In the present study, we confirmed that SETDB1 exhibited higher expression levels in nasopharyngeal carcinoma (NPC) tissues and cell lines, compared to these levels in non‑tumor tissues and a normal human nasopharyngeal epithelial cell line. Read More

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http://dx.doi.org/10.3892/or.2018.6490DOI Listing
August 2018
10 Reads

Lymphoepithelioma-like breast carcinoma.

Pol J Pathol 2018;69(1):98-104

Nasopharyngeal lymphoepithelioma is an undifferentiated carcinoma in a dominated lymphoplasma-histiocyte stroma. Lymphoepithelioma-like carcinoma of the breast is the mammary counterpart of the lymphoepithelioma of the nasopharynx and is characterised by proliferation of poorly differentiated malignant cells within a prominent lymphoid infiltrate. It is a very rare primary carcinoma of the breast first reported in 1994 by Kumar and Kumar. Read More

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http://dx.doi.org/10.5114/pjp.2018.75344DOI Listing
July 2018
4 Reads
0.832 Impact Factor

Head and Neck Tumors: Amide Proton Transfer MRI.

Radiology 2018 09 12;288(3):782-790. Epub 2018 Jun 12.

From the Department of Imaging and Interventional Radiology (B.K.H.L., A.D.K., Q.Y.A., W.C., A.T.A., Y.X.W.) and Department of Clinical Oncology (D.M.C.P., B.B.M., D.K.W.Y., F.K.F.M.), State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong SAR, China; Department of Imaging, St Mary's Hospital, Imperial College Healthcare, National Health Service Trust, London, England (K.S.B.); and Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong SAR, China (J.Y.).

Purpose To evaluate the utility of amide proton transfer (APT) imaging in the characterization of head and neck tumors. Materials and Methods This retrospective study of APT imaging included 117 patients with 70 nasopharyngeal undifferentiated carcinomas (NUCs), 26 squamous cell carcinomas (SCCs), eight non-Hodgkin lymphomas (NHLs), and 13 benign salivary gland tumors (BSGTs). Normal tissues were examined in 25 patients. Read More

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http://dx.doi.org/10.1148/radiol.2018171528DOI Listing
September 2018
33 Reads

The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation.

Clin Exp Pharmacol Physiol 2018 Oct 5;45(10):1019-1027. Epub 2018 Jul 5.

Department of Pharmacology, Medical College, Jinan University, Guangzhou, China.

Zoledronic acid (ZA), a third-generation bisphosphonate, has been applied for treatment of bone metastases caused by malignant tumors. Recent studies have found its anti-cancer effects on various tumor cells. One of the mechanisms of anti-cancer effects of ZA is induction of apoptosis. Read More

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http://dx.doi.org/10.1111/1440-1681.12979DOI Listing
October 2018
18 Reads

Infection by Epstein-Barr virus in Fes (Morocco). Prevalence and predictors of positivity in nasopharyngeal cancer.

J Infect Public Health 2018 Nov - Dec;11(6):807-811. Epub 2018 Jun 2.

Human Anatomy and Embryology Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Madrid, Spain.

Objectives: To determine the prevalence and genotypic distribution of Epstein-Barr virus (EBV) in a sample of patients of Hassan II University Hospital (Morocco) due to nasopharyngeal pathologies and requiring a biopsy. We identified factors associated to the EBV infection.

Methods: 112 patients were recruited (January 2012-October 2014). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18760341183007
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http://dx.doi.org/10.1016/j.jiph.2018.05.005DOI Listing
December 2018
8 Reads

Case Report of Myeloid Sarcoma Masquerading as In-Transit Metastasis at a Previous Melanoma Site: Avoiding a Diagnostic Pitfall.

Am J Dermatopathol 2018 Nov;40(11):831-835

Surgical Oncology, and.

Myeloid sarcoma is a rare extramedullary hematologic malignancy. Accurate and timely diagnosis may be challenging because myeloid sarcoma is known to mimic solid tumors, including hepatobiliary, nasopharyngeal, and breast carcinomas. We report a case of myeloid sarcoma that developed in the primary tumor lymphatic drainage field of a previously treated intermediate-thickness cutaneous melanoma, clinically and radiographically mimicking an in-transit metastasis, in a patient with myelodysplastic syndrome. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001150DOI Listing
November 2018
8 Reads
1.430 Impact Factor

The role of nasopharyngeal examination and biopsy in the diagnosis of malignant diseases.

Braz J Otorhinolaryngol 2018 May 15. Epub 2018 May 15.

University of Health Sciences, Ankara Training and Research Hospital, Department of Pathology, Ankara, Turkey.

Introduction: In direct proportion to the increasing rate of nasopharynx examinations applied, the early diagnosis and treatment of lesions in this region is possible. At times the clinical findings and the biopsy results are not consistent, so biopsies may have to be repeated.

Objectives: The aim of this study was to evaluate the distribution of pathology test results obtained from cases of nasopharynx biopsy, to determine with which methods determination most often was made, and to investigate which kinds of cases required the biopsy to be repeated. Read More

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http://dx.doi.org/10.1016/j.bjorl.2018.04.006DOI Listing
May 2018
3 Reads

The value of shear wave elastography in predicting for undiagnosed small cervical lymph node metastasis in nasopharyngeal carcinoma: A preliminary study.

Eur J Radiol 2018 Jun 5;103:19-24. Epub 2018 Mar 5.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, PR China. Electronic address:

Background: To investigate the diagnostic value of shear wave elastography (SWE) in identifying cervical small lymph node metastases in nasopharyngeal carcinoma (NPC) patients.

Materials And Methods: This prospective study was approved by the local institutional review board. From July 2014 to March 2016, 114 sLNs from 62 newly diagnosed NPC patients (47 men, 15 women) were assessed. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.03.006DOI Listing
June 2018
2 Reads

[Transnasal endoscopic surgery of communicating neoplasm outside cerebral dura mater and orbital fasciae].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Aug;31(16):1276-1280

Department of Otolaryngology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, China.

This paper is intend to observe the feasibility of surgical approach with which communicating neoplasm outside cerebral dura mater and orbital fasciae was removed by transnasal endoscopic surgery.Nine patients suffered from communicating neoplasm in the area of naso-orbital-cranio complex were treated with transnasal endoscopic surgery. The size of skull base bone defect was from 1. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2017.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2017.16.014DOI Listing
August 2017
3 Reads

[Nasopharyngeal atypical carcinoid misdiagnosed as a cyst:one case report].

Authors:

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Apr;32(7):556-558

Atypical carcinoid ,a kind of neuroendocrine tumor(NET),rarely shows its malignant manifestations firstly in otorhinolaryngology including atypical clinical features of symptoms such as rapid tumor growth, extensive invasion, high rate of metastasis and poor prognosis. Based on the clinical data of a nasopharyngeal atypical carcinoid patient diagnosed and treated recently in our hospital,a literature review including its biological behavior, diagnosis and treatment methods was present so as to further improve the understanding of such kind of tumor. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.07.021DOI Listing

[The relationship between pathology and imaging overview in pediatric nasal tumors].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Oct;31(20):1570-1574

Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.

To study the clinical features and nasal image of children with nasal tumors.The samples of 40 cases of pediatric nasal tumors, which were diagnosed based on pathology, were collected. Clinical features, pathological histology and imaging characteristics were also summarized. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2017.20.007DOI Listing
October 2017
4 Reads

A novel oncogene URG4/URGCP and its role in cancer.

Gene 2018 Aug 18;668:12-17. Epub 2018 May 18.

Ankara University Medical Faculty Department of Forensic Medicine, Ankara, Turkey.

Oncogenes are mutated form of normal cellular genes called as proto-oncogenes and conduce to the cancer development process. Despite the fact that so many genes have been described, new genes with oncogenic characteristic and potential or tumor supressoring activity are still being defined. Recently, Up-regulated gene 4/Upregulator of cell proliferation (URG4/URGCP), a novel gene, induced by hepatitis-Bvirus-encoded X antigen (HBxAg), has been identified. Read More

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http://dx.doi.org/10.1016/j.gene.2018.05.047DOI Listing
August 2018
1 Read

Influence of POLG on Radiosensitivity of Nasopharyngeal Carcinoma Cells.

Cancer Biother Radiopharm 2018 May;33(4):146-154

1 Central Laboratory, First Affiliated Hospital of Fujian Medical University , Fuzhou, China .

Background And Objective: There is a high incidence of nasopharyngeal carcinoma (NPC), malignant head and neck tumors, in southern China. Radioresistance is the main cause affecting the efficacy of NPC treatments. The POLG gene particularly plays an important role in radiation-induced damage repair. Read More

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http://dx.doi.org/10.1089/cbr.2017.2346DOI Listing
May 2018
2 Reads