1,731 results match your criteria Malignant Nasopharyngeal Tumors


Radiation-enhanced expression of CCL22 in nasopharyngeal carcinoma is associated with CCR4 CD8 T cell recruitment.

Int J Radiat Oncol Biol Phys 2020 May 16. Epub 2020 May 16.

Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; Key Laboratory of Molecular Radiation Oncology Hunan Province, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha 410008, Hunan, China; Hunan International Scientific and Technological Cooperation Base of Precision Medicine for Cancer, Changsha 410008, Hunan, China. Electronic address:

Purpose: Radiotherapy (RT) elicits profound alterations in gene expression in tumor cells. This study is to determine the dynamic changes of the expression of immunity-associated genes in nasopharyngeal carcinoma (NPC) cells upon RT.

Methods And Materials: The study was performed using NPC PDX tumors, cell lines, CCR4 CD8 T cells sorted from peripheral blood mononuclear cells (PBMCs) of healthy volunteers and TCGA-derived bulk RNA-seq or single-cell RNA-seq (scRNA-seq) datasets. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.05.001DOI Listing

MicroRNA‑19b inhibitors can attenuate the STAT3 signaling pathway in NPC C666‑1 cells.

Mol Med Rep 2020 Jul 4;22(1):51-56. Epub 2020 May 4.

Department of Pathology, The Second Affiliated Hospital, Guilin Medical University, Guilin, Guangxi 541199, P.R. China.

MicroRNA (miR)-19b is expressed in various types of tumors and may serve as a potential therapeutic target. The miR‑17‑92 cluster is upregulated in nasopharyngeal carcinoma (NPC) tissues and cells. miR‑19b is a member of the miR‑17‑92 cluster; however, its expression and function in NPC are largely unknown. Read More

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http://dx.doi.org/10.3892/mmr.2020.11112DOI Listing

Multiple Mechanisms Involving in Radioresistance of Nasopharyngeal Carcinoma.

J Cancer 2020 25;11(14):4193-4204. Epub 2020 Apr 25.

Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Nasopharyngeal carcinoma (NPC) is the malignant tumor with ethnic and geographical distribution preference. Although intensity-modulated radiotherapy (IMRT)-based radiotherapy combined with chemotherapy and targeted therapy has dramatically improved the overall survival of NPC patients, there are still some patients suffering from recurrent tumors and the prognosis is poor. Multiple mechanisms may be responsible for radioresistance of NPC, such as cancer stem cells (CSCs) existence, gene mutation or aberrant expression of genes, epigenetic modification of genes, abnormal activation of certain signaling pathways, alteration of tumor microenvironment, stress granules (SGs) formation, . Read More

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http://dx.doi.org/10.7150/jca.39354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196263PMC

Juvenile Nasal Angiofibroma on Ga-DOTANOC PET/CT: Exploring Theranostic Avenues.

Indian J Nucl Med 2020 Apr-Jun;35(2):176-177. Epub 2020 Mar 12.

Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Somatostatin (SST) cell surface receptors (SSTRs) are expressed in many different malignant, benign, and neuroendocrine tumors. SSTRs are also expressed in the endothelium of human vessels during angiogenesis and not in the nonproliferating vessels. We present a case of 19-year-old boy with juvenile nasal angiofibroma (JNA), who underwent Ga-DOTANOC PET/CT to explore SSTRs expression and theranostic potential. Read More

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http://dx.doi.org/10.4103/ijnm.IJNM_207_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182334PMC

MiRNAs in Radiotherapy Resistance of Nasopharyngeal Carcinoma.

J Cancer 2020 6;11(13):3976-3985. Epub 2020 Apr 6.

The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation Oncology, Hunan Province, 283 Tongzipo Road, Changsha 410013, Hunan, China.

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors of the head and neck in Southeast Asia and southern China. Although the comprehensive treatment based on intensity-modulated radiation therapy improves outcomes, the five-year survival rate of NPC patients is low, and the recurrence remains high. Radiotherapy resistance is the main cause of poor prognosis in NPC patients. Read More

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http://dx.doi.org/10.7150/jca.42734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171507PMC

Homeodomain protein DLX4 facilitates nasopharyngeal carcinoma progression via up-regulation of YB-1.

Genes Cells 2020 Apr 12. Epub 2020 Apr 12.

Department of Otolaryngology Head and neck surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing City, China.

Nasopharyngeal carcinoma (NPC) is a malignant tumor in nasopharynx tissues and lacks effective treatment strategies. Dysregulation of distal-less homeobox 4 (DLX4) participates in the development of tumors. Understanding the regulatory mechanism of DLX4 in NPC progression may address this issue. Read More

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http://dx.doi.org/10.1111/gtc.12772DOI Listing
April 2020
2.805 Impact Factor

lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial-to-mesenchymal transition.

Oncol Lett 2020 Apr 14;19(4):2721-2726. Epub 2020 Feb 14.

Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors. Studies have indicated that long noncoding RNAs (lncRNAs) function as important regulators in progression of tumorigenesis. In this study, lncRNA small nucleolar RNA host gene 7 (SNHG7) was selected to identify how it functioned in the development of NPC. Read More

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http://dx.doi.org/10.3892/ol.2020.11397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068656PMC

The Role of a Minimum Immunohistochemical Antibody Panel in Confirming Undifferentiated Nasopharyngeal Carcinoma: A Cross-Sectional Study at the Muhimbili National Hospital, Dar-es-Salaam, Tanzania.

Niger Med J 2019 Nov-Dec;60(6):279-284. Epub 2020 Feb 24.

Department of Pathology, Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania.

Introduction: Nasopharyngeal carcinoma (NPC) is a malignant epithelial neoplasm arising in the nasopharyngeal mucosa that shows light microscopic and/or ultrastructural evidence of squamous differentiation. Immunohistochemistry (IHC) can be used to reliably distinguish undifferentiated NPC from other malignant tumors, and the technique may be a necessary tool toward the arrival of a definitive diagnosis, particularly when dealing with challenging cases.

Materials And Methods: This was a cross-sectional hospital-based study which was conducted at Muhimbili National Hospital. Read More

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http://dx.doi.org/10.4103/nmj.NMJ_134_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053275PMC
February 2020

The preoperative systemic inflammation response index (SIRI) independently predicts survival in postmenopausal women with breast cancer.

Curr Probl Cancer 2020 Feb 24:100560. Epub 2020 Feb 24.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, China; Department of Radiotherapy, Sun Yat-sen University Cancer Center, China. Electronic address:

The recently developed preoperative systemic inflammation response index (SIRI) was reported as a useful biomarker that could predict survival in certain types of malignant tumors. However, the prognostic value of preoperative SIRI in postmenopausal breast cancer remains unclear. This study aimed to explore the relationship between SIRI and survival in postmenopausal patients with breast cancer. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2020.100560DOI Listing
February 2020

CircPSMC3 inhibits cell proliferation and induces cell apoptosis in nasopharyngeal carcinoma by downregulating ROCK1.

Eur Rev Med Pharmacol Sci 2020 Feb;24(3):1219-1225

Department of Otolaryngology Head and Neck Surgery, People's Liberation Army Hospital 960 Ziboyuan District, Zibo, China.

Objective: Currently, the importance of circular RNAs in malignant tumors has attracted much attention. However, the role of circPSMC3 in nasopharyngeal carcinoma (NPC) remains unclear. The aim of this study was to investigate the function of circPSMC3 in the proliferation and apoptosis of NPC and to explore its possible underlying mechanism. Read More

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http://dx.doi.org/10.26355/eurrev_202002_20174DOI Listing
February 2020

Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma.

Cancer Lett 2020 May 13;477:131-143. Epub 2020 Feb 13.

NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. Electronic address:

Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in Southern China and southeast Asia, which is characterized by a dense lymphocyte infiltration and a poor prognosis. The emergence of single-cell sequencing represents a powerful tool to resolve tumor heterogeneity and delineate the complex communication among the tumor cells with neighboring stromal and immune cells in the tumor microenvironment (TME). Here, we performed single cell RNA-seq and analyzed tumor cells together with the infiltrating immune cells from three NPC tumor tissues. Read More

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http://dx.doi.org/10.1016/j.canlet.2020.02.010DOI Listing

Chordoma with lung metastases at initial presentation of a pediatric patient.

Radiol Case Rep 2020 Apr 5;15(4):382-386. Epub 2020 Feb 5.

Department of Diagnostic Imaging and Radiology, University of Missouri Hospital/ Women's and Children's Hospital, Columbia, MO, USA.

Chordomas are rare, slow growing malignant tumors derived from notochord remnants that can arise anywhere along the neuronal axis. Chordomas are particularly rare in patients under 20 years of age and tend to be intracranial in location, as opposed to sacrococcygeal in adults. Metastasis at initial presentation is uncommon in all age groups and is exceedingly rare in the absence of local recurrence of the primary tumor. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005512PMC

Comparison of 68Ga-PSMA PET/CT and Contrast-Enhanced MRI on Residual Disease Assessment of Juvenile Nasal Angiofibroma.

Clin Nucl Med 2020 Apr;45(4):308-309

Nuclear Medicine.

Prostate-specific membrane antigen (PSMA) is expressed in the endothelial cells of tumor-associated neovasculature of various nonprostatic benign and malignant neoplasms including juvenile nasopharyngeal angiofibroma (JNA). Positive uptake on PET/CT imaging with Ga-labeled PSMA is noted in a patient with residual disease after initial surgery without any abnormal uptake in postoperative fibrosis, in contrast to contrast-enhanced MRI, which was confirmed by biopsy. Ga-PSMA PET/CT may be a useful tool clinically for identifying early biochemical recurrences and in specifically differentiating recurrences from surgical site reparative tissue. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002951DOI Listing
April 2020
3.931 Impact Factor

Pin2 telomeric repeat factor 1-interacting telomerase inhibitor 1 (PinX1) inhibits nasopharyngeal cancer cell stemness: implication for cancer progression and therapeutic targeting.

J Exp Clin Cancer Res 2020 Feb 7;39(1):31. Epub 2020 Feb 7.

Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.

Background: Recurrence and distant metastasis are still the main factors leading to treatment failure for malignant tumors including nasopharyngeal carcinoma (NPC). Therefore, elucidating the molecular mechanisms underlying nasopharyngeal carcinoma metastasis is of great clinical significance for targeted gene therapy and prognostic evaluation. PinX1, a tumor suppressor gene, was previously demonstrated to be a powerful tool for targeting telomerase in order to resist malignant tumor proliferation and migration. Read More

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http://dx.doi.org/10.1186/s13046-020-1530-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006127PMC
February 2020

The role of long noncoding RNAs in regulating invasion and metastasis of malignant tumors.

Anticancer Drugs 2020 04;31(4):319-325

Department of Pediatric Surgery, Hunan Children's Hospital, Changsha, People's Republic of China.

Long noncoding RNAs (lncRNAs) are a group of non-protein-coding transcripts exceeding 200 nucleotides in length, which are emerging as key players in various fundamental biological processes. Furthermore, it is increasingly recognized that mutation and dysregulation of lncRNAs contribute importantly to a variety of human diseases, particularly human cancers. Previous studies have revealed that altered lncRNAs have a close association with tumorigenesis, metastasis, prognosis and diagnosis of cancers. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000899DOI Listing

Long noncoding RNA ROR1-AS1 induces tumor metastasis and epithelial-mesenchymal transition by sponging miR-375 in nasopharyngeal carcinoma.

Eur Rev Med Pharmacol Sci 2020 Jan;24(1):174-180

Department of Otolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xian, China.

Objective: The vital role of long noncoding RNAs (lncRNAs) in tumor progression has been identified in numerous studies. Nasopharyngeal carcinoma (NPC) is one of the most ordinary malignant tumors. This study aims to explore the role of lncRNA ROR1-AS1 in the metastasis of NPC. Read More

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http://dx.doi.org/10.26355/eurrev_202001_19909DOI Listing
January 2020

Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck.

Head Neck Pathol 2020 Mar 16;14(1):43-58. Epub 2020 Jan 16.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Fibroblastic and myofibroblastic neoplasms of the head and neck encompass a group of rare tumor types with often overlapping clinicopathologic features that range in biologic potential from benign to overtly malignant. Even neoplasms with no metastatic potential may provide significant therapeutic challenges in this region due to the unique anatomy of the head and neck. This review will cover the following entities, highlighting important clinical aspects of each neoplasm and then focusing on their characteristic histomorphology, immunophenotype, and molecular alterations: nodular and cranial fasciitis, fibrous hamartoma of infancy, nasopharyngeal angiofibroma, nuchal-type and Gardner fibromas, desmoid fibromatosis, dermatofibrosarcoma protuberans and giant cell fibroblastoma, solitary fibrous tumor, inflammatory myofibroblastic tumor, low-grade myofibroblastic sarcoma, infantile fibrosarcoma, low-grade fibromyxoid sarcoma, and sclerosing epithelioid fibrosarcoma. Read More

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http://dx.doi.org/10.1007/s12105-019-01104-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021862PMC

Exosomes overexpressing miR-34c inhibit malignant behavior and reverse the radioresistance of nasopharyngeal carcinoma.

J Transl Med 2020 Jan 8;18(1):12. Epub 2020 Jan 8.

Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People's Republic of China.

Background: Malignant behavior and radioresistance, which severely limits the efficacy of radiation therapy (RT) in nasopharyngeal carcinoma (NPC), are associated with tumor progression and poor prognosis. Mesenchymal stem cells (MSCs) are used as a therapeutic tool in a variety of tumors. The aim of this study was to reveal the effect of tumor suppressor microRNA-34c-5p (miR-34c) on NPC development and radioresistance, as well as to confirm that exosomes derived from MSCs overexpressing miR-34c restore the sensitivity to radiotherapy in NPCs. Read More

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http://dx.doi.org/10.1186/s12967-019-02203-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947927PMC
January 2020

Novel EBV LMP-2-affibody and affitoxin in molecular imaging and targeted therapy of nasopharyngeal carcinoma.

PLoS Pathog 2020 01 6;16(1):e1008223. Epub 2020 Jan 6.

Institute of Molecular Virology and Immunology, Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, PR China.

Epstein-Barr virus (EBV) infection is closely linked to several human malignancies including endemic Burkitt's lymphoma, Hodgkin's lymphoma and nasopharyngeal carcinomas (NPC). Latent membrane protein 2 (LMP-2) of EBV plays a pivotal role in pathogenesis of EBV-related tumors and thus, is a potential target for diagnosis and targeted therapy of EBV LMP-2+ malignant cancers. Affibody molecules are developing as imaging probes and tumor-targeted delivery of small molecules. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964910PMC
January 2020

miR-429 as biomarker for diagnosis, treatment and prognosis of cancers and its potential action mechanisms: A systematic literature review.

Neoplasma 2020 Mar 23;67(2):215-228. Epub 2019 Dec 23.

Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.

miR-429 is a member of miR-200 family. Accumulated evidence has indicated that miR-429 dysregulation is involved in the epithelial-mesenchymal transition (EMT), progression, development, invasion, metastasis, apoptosis and drug resistance of a variety of cancers. miR-429 might specifically function either as a tumor suppressor or promoter candidate for certain cancers depending on the particular types of tumor cells/tissues. Read More

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http://dx.doi.org/10.4149/neo_2019_190401N282DOI Listing

Extramedullary plasmacytoma of the kidney in an HIV-positive patient: A case report.

Medicine (Baltimore) 2019 Dec;98(52):e18422

Department of Urology.

Rationale: Extramedullary plasmacytoma (EMP) is a very rare malignant neoplasm arising from clonal proliferation of atypical plasma cells. Most EMPs involve mucosal lymphoid tissue, particularly in the nasopharyngeal area, respiratory tract, and head and neck region. Such neoplasms of the kidney in patients with a human immunodeficiency virus (HIV) infection are extremely rare. Read More

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http://dx.doi.org/10.1097/MD.0000000000018422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946407PMC
December 2019

Long noncoding RNA cytoskeleton regulator RNA promotes cell invasion and metastasis by titrating miR-613 to regulate ANXA2 in nasopharyngeal carcinoma.

Cancer Med 2020 Feb 20;9(3):1209-1219. Epub 2019 Dec 20.

Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Department of Epidemiology, Collaborative Innovation Center For Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.

Background: Nasopharyngeal carcinoma (NPC) is one of the most frequent head and neck malignant tumors. Long noncoding RNAs play critical roles in tumorigenesis.

Methods: Real-time quantitative PCR arrays were used to evaluate the expression levels of cytoskeleton regulator RNA (CYTOR) in NPC tissues and cells. Read More

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http://dx.doi.org/10.1002/cam4.2778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997049PMC
February 2020

From Juvenile Nasopharyngeal Angiofibroma to Nasopharyngeal Carcinoma; A Rare Case Report of Nasopharyngeal Mass.

Bull Emerg Trauma 2019 Oct;7(4):424-426

Department of Rhinology and Skull Base Surgery, ENT and Head and Neck Research Center, Hazrat Rasoul Hospital, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran.

Nasopharyngeal masses in young males, first of all presumes Juvenile Nasopharyngeal Angiofibroma (JNA) in the mind, but other benign or malignant tumors should be considered for successful and adequate management of patients and also for minimizing morbidity from unnecessary interventions. We herein present a patient with nasopharyngeal carcinoma (NPC) mimicking JNA. The patient was presumed as JNA and underwent excessive surgical intervention and the final histopathology report was NPC. Read More

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http://dx.doi.org/10.29252/beat-070414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911716PMC
October 2019

Nasopharyngeal Hyalinizing Clear Cell Carcinoma: A Case Report and Review of the Literature.

Allergy Rhinol (Providence) 2019 Jan-Dec;10:2152656719889030. Epub 2019 Nov 20.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors which most often arise from the minor salivary glands primarily in palate and tongue but can arise in any location with minor salivary glands including the nasopharynx.

Methods: A case report of primary nasopharyngeal HCCC is presented. Because of the rarity of this tumor and location, a literature search was conducted to determine the most common presenting symptoms, treatment strategies, and outcomes. Read More

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http://dx.doi.org/10.1177/2152656719889030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883668PMC
November 2019

Circular RNA_LARP4 inhibits cell proliferation and invasion of nasopharyngeal carcinoma by repressing ROCK1.

Authors:
J-Y Pan X-L Bao K Zhu

Eur Rev Med Pharmacol Sci 2019 Nov;23(22):9915-9922

Department of Otorhinolaryngology, Haining People's Hospital, Haining, China.

Objective: Nasopharyngeal carcinoma (NPC) is one of the most ordinary malignant tumors. Recent studies have revealed that circular RNAs play an important role in the progression of tumorigenesis. This study aims to identify how circular RNA_LARP4 functions in the progression of NPC. Read More

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http://dx.doi.org/10.26355/eurrev_201911_19557DOI Listing
November 2019

Association Between Dose and Duration of Cisplatin Exposure with Cytotoxicity Effect on Nasopharyngeal Carcinoma Stem Cell.

Indian J Otolaryngol Head Neck Surg 2019 Oct 29;71(Suppl 1):373-377. Epub 2018 Mar 29.

Department of Otorhinolaryngology, Faculty of Medicine Universitas Airlangga - Dr. Soetomo General Hospital, Surabaya, Indonesia.

Nasopharyngeal carcinoma (NPC) is ranked 6th of malignant tumors in Indonesia. To analyze the correlation of dose and duration of cisplatin exposure with cytotoxic effects on nasopharyngeal carcinoma stem cells. The biopsy NPC tissue was cultured and processed to obtain NPC stem cells to be treated with cisplatin different doses and durations (24 and 48 h). Read More

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http://dx.doi.org/10.1007/s12070-018-1317-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848681PMC
October 2019

TSPAN8 serves as a prognostic marker involving Akt/MAPK pathway in nasopharyngeal carcinoma.

Ann Transl Med 2019 Sep;7(18):470

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.

Background: Nasopharyngeal carcinoma (NPC) is a common epithelial carcinoma with high occurrence and metastatic rates in Southern China. To date, the molecular mechanisms of metastasis for NPC remains unclear. The aim of this study was to discover the underlying mechanism of NPC and to elucidate novel genes that may play important roles in NPC progression and metastasis. Read More

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http://dx.doi.org/10.21037/atm.2019.08.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803210PMC
September 2019

Long non-coding RNA CASC15 promotes nasopharyngeal carcinoma cell proliferation and metastasis by downregulating miR-101-3p.

Authors:
M-Y Xue H-X Cao

Eur Rev Med Pharmacol Sci 2019 Oct;23(20):8897-8904

Department of Otorhinolaryngology-Head and Neck Surgery, Affiliated Hospital of Jiangnan University (The Fourth People's Hospital of Wuxi), Wuxi, China.

Objective: Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors worldwide. Recent studies have revealed that long non-coding RNAs (lncRNAs) play important roles in the progression of tumorigenesis. The aim of this study was to identify the exact role of lncRNA CASC15 in the progression of NPC. Read More

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http://dx.doi.org/10.26355/eurrev_201910_19285DOI Listing
October 2019

Potentially functional variants of autophagy-related genes are associated with the efficacy and toxicity of radiotherapy in patients with nasopharyngeal carcinoma.

Mol Genet Genomic Med 2019 12 6;7(12):e1030. Epub 2019 Nov 6.

Department of Radiology, Shengjing Hospital Affiliated to China Medical University, Shenyang, China.

Background: Nasopharyngeal carcinoma (NPC) is one of the major invasive malignant neoplasms of head and neck, while radiotherapy is the primary therapy for NPC. Genetic variants could affect the efficacy and toxicities of radiotherapy in NPC patients.

Methods: In the current study, we aimed to investigate 10 potentially functional SNPs of autophagy-related genes (ATG) with the efficacy and toxicity of radiotherapy in 468 NPC patients. Read More

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http://dx.doi.org/10.1002/mgg3.1030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900379PMC
December 2019

Capn4 is induced by and required for Epstein-Barr virus latent membrane protein 1 promotion of nasopharyngeal carcinoma metastasis through ERK/AP-1 signaling.

Cancer Sci 2020 Jan 25;111(1):72-83. Epub 2019 Nov 25.

College of Pharmacy, Fujian Medical University, Fuzhou, China.

Capn4, also known as CapnS1, is a member of the calpain family, which plays a crucial role in maintaining the activity and function of calpain. We previously reported that Capn4 also plays an essential role in the migration of nasopharyngeal carcinoma (NPC) cells through regulation of (MMP-2) by nuclear factor-kappa B activation. Epstein-Barr virus latent membrane protein 1 (LMP1) is closely related to the malignant functions of NPC; however, the relationship between LMP1 and Capn4 in NPC remain unclear. Read More

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http://dx.doi.org/10.1111/cas.14227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942433PMC
January 2020

Clinical and biological significances of heat shock protein 90 (Hsp90) in human nasopharyngeal carcinoma cells and anti-cancer effects of Hsp90 inhibitor.

Biomed Pharmacother 2019 Dec 18;120:109533. Epub 2019 Oct 18.

Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, PR China. Electronic address:

Nasopharyngeal carcinoma (NPC) is a malignant tumor in South China, characterized with high death rate. If untreated, NPC cells will be invasiveness and then spread to other tissues. In clinical practice, however, lack of early effective screening to prevent the NPC development. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.109533DOI Listing
December 2019
1 Read

Otitis Media With Effusion Caused by a Parapharyngeal Tumor Showing Normal Nasopharyngeal Findings.

Ear Nose Throat J 2019 Oct 13:145561319881513. Epub 2019 Oct 13.

Department of Otolaryngology, Juntendo University Nerima Hospital, Tokyo, Japan.

The objective of this study is to evaluate otitis media with effusion (OME) among patients with parapharyngeal tumor. We have experienced 82 parapharyngeal tumor cases and encountered 14 patients complaining of hearing loss due to OME as the initial symptom. These patients showed normal nasopharyngeal findings and the presence of tumor had been detected long time after the beginning of their hearing symptoms (4 months to 13 years: median 2. Read More

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http://dx.doi.org/10.1177/0145561319881513DOI Listing
October 2019
1 Read

Plasma levels of soluble programmed death ligand 1 (sPD-L1) in WHO II/III nasopharyngeal carcinoma (NPC): A preliminary study.

Medicine (Baltimore) 2019 Sep;98(39):e17231

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences.

Plasma levels of soluble PD-L1 (sPD-L1) have been reported to be an independent prognostic factor in many malignant tumors. The expression of sPD-L1 in nasopharyngeal carcinoma (NPC) has not been reported. The purpose of this study was to evaluate the expression of sPD-L1 and analyze its correlation with clinical characteristics in patients with NPC. Read More

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http://dx.doi.org/10.1097/MD.0000000000017231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775345PMC
September 2019
2 Reads

Down-regulation of miR-155 promotes apoptosis of nasopharyngeal carcinoma CNE-1 cells by targeting PI3K/AKT-FOXO3a signaling.

Authors:
S Wu D-L Xie X-Y Dai

Eur Rev Med Pharmacol Sci 2019 Sep;23(17):7391-7398

Department of E.N.T. & H.N, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China.

Objective: Nasopharyngeal carcinoma is one of the common malignant tumors of the ear, nose, and throat in China. Cell apoptosis is expected to be closely related to prognosis. In recent years, with the development of non-coding RNA function research, it is proposed that miRNA plays an important role in the pathogenesis of nasopharyngeal carcinoma. Read More

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http://dx.doi.org/10.26355/eurrev_201909_18847DOI Listing
September 2019
1 Read

Endoscopic Resection of Pediatric Skull Base Tumors: An Evidence-Based Review.

J Neurol Surg B Skull Base 2019 Oct 11;80(5):527-539. Epub 2018 Dec 11.

Department of Otolaryngology - Head and Neck Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, New Jersey, United States.

 To perform a systematic review examining experiences with endoscopic resection of skull base lesions in the pediatric population, with a focus on outcomes, recurrence, and surgical morbidities.  PubMed/MEDLINE, Cochrane Library, Embase, and Web of Science databases were evaluated. Studies were assessed for level of evidence. Read More

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http://dx.doi.org/10.1055/s-0038-1676305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748853PMC
October 2019
6 Reads

The Glypican-4 Gene Polymorphism rs1048369 and Susceptibility to Epstein-Barr Virus-Positive and -Negative Nasopharyngeal Carcinoma in Northern China.

Oncol Res Treat 2019 13;42(11):572-579. Epub 2019 Sep 13.

Department of Medical Microbiology, Qingdao University Medical College, Qingdao, China,

Background: Gene polymorphism rs1048369 of glypican-4 (GPC4) gene has been reported to be significantly different between Epstein-Barr virus (EBV)-associated gastric carcinoma (GC) and EBV-negative GC. However, little is known about the polymorphism in nasopharyngeal carcinoma (NPC), which is a malignant tumor with a high prevalence of EBV.

Objective: The distribution of GPC4 polymorphism rs1048369 was investigated in NPC patients, especially in those with EBV infection. Read More

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https://www.karger.com/Article/FullText/502753
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http://dx.doi.org/10.1159/000502753DOI Listing
April 2020
3 Reads

Correlation between IL-17A expression in nasopharyngeal carcinoma tissues and cells and pathogenesis of NPC in endemic areas.

Eur Arch Otorhinolaryngol 2019 Nov 27;276(11):3131-3138. Epub 2019 Aug 27.

Admin Office, Renmin Hospital, Hubei University of Medicine, No. 39 Middle Chaoyang Road, Maojian District, Shiyan, 442000, Hubei, People's Republic of China.

Objective: We investigated the correlation between the expression of IL-17A in nasopharyngeal carcinoma tissues and cells and the occurrence and development of NPC was also investigated.

Methods: Forty-five NPC biopsy specimens from January 2014 to January 2016 were selected. Forty-five NPC tissue specimens and 45 chronic nasopharyngitis tissue samples were detected by immunohistochemistry. Read More

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http://dx.doi.org/10.1007/s00405-019-05608-0DOI Listing
November 2019

The Global Landscape of EBV-Associated Tumors.

Front Oncol 2019 6;9:713. Epub 2019 Aug 6.

Institute for Immunology and Immunotherapy, The University of Birmingham, Birmingham, United Kingdom.

Epstein-Barr virus (EBV), a gamma-1 herpesvirus, is carried as a life-long asymptomatic infection by the great majority of individuals in all human populations. Yet this seemingly innocent virus is aetiologically linked to two pre-malignant lymphoproliferative diseases (LPDs) and up to nine distinct human tumors; collectively these have a huge global impact, being responsible for some 200,000 new cases of cancer arising worldwide each year. EBV replicates in oral epithelium but persists as a latent infection within the B cell system and several of its diseases are indeed of B cell origin; these include B-LPD of the immunocompromised, Hodgkin Lymphoma (HL), Burkitt Lymphoma (BL), Diffuse Large B cell Lymphoma (DLBCL) and two rarer tumors associated with profound immune impairment, plasmablastic lymphoma (PBL) and primary effusion lymphoma (PEL). Read More

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http://dx.doi.org/10.3389/fonc.2019.00713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691157PMC
August 2019
7 Reads

Secreted TGF-beta-induced protein promotes aggressive progression in bladder cancer cells.

Cancer Manag Res 2019 25;11:6995-7006. Epub 2019 Jul 25.

The Third Clinical College of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.

Transforming growth factor-beta-induced (TGFBI) is an exocrine protein, which has been found to be able to promote the development of nasopharyngeal carcinoma, glioma, pancreatic cancer, and other tumors. However, there is currently no report concerning the relationship between TGFBI and invasive progression of bladder cancer (BCa). IHC staining, qRT-PCR and Western blot were used to analyze TGFBI and EMT markers levels. Read More

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http://dx.doi.org/10.2147/CMAR.S208984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664251PMC
July 2019
7 Reads

NKILA represses nasopharyngeal carcinoma carcinogenesis and metastasis by NF-κB pathway inhibition.

PLoS Genet 2019 08 20;15(8):e1008325. Epub 2019 Aug 20.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.

The role of long non-coding RNA (lncRNA) in the progression of Nasopharyngeal carcinoma (NPC) has not been fully elucidated. The study was designed to explore the functional role of NKILA, a newly identified lncRNA, in the progression of NPC. We performed a lncRNA expression profile microarray using four NPC and paired para-cancerous tissues. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716677PMC

Nasopharyngeal undifferentiated carcinoma with sarcomatoid features: Pitfalls in the immunohistochemistry.

Malays J Pathol 2019 Aug;41(2):201-206

Eulji University School of Medicine, Department of Radiation Oncology, Daejeon, Republic of Korea.

We present a case of an undifferentiated subtype of non-keratinizing squamous cell carcinoma (NK-SCC) with sarcomatoid features in the nasopharynx in a 69-year-old man who was difficult to diagnose due to spindle-shaped malignant cells. He was admitted because of a right nasal obstruction and right headache, and imaging revealed a heterogeneously enhanced irregularly shaped mass at the nasopharynx. Histopathologically, the tumour was partially organised, and the tumour cells were epithelioid or spindle-shaped. Read More

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August 2019
2 Reads

Loss of Cirbp expression is correlated with the malignant progression and poor prognosis in nasopharyngeal carcinoma.

Cancer Manag Res 2019 24;11:6959-6969. Epub 2019 Jul 24.

Guangdong Provincial Key Laboratory of Cancer Immunotherapy Research and Guangzhou Key Laboratory of Tumor Immunology Research, Cancer Research Institute, Southern Medical University, Guangzhou 510515, People's Republic of China.

The correlation of cold-inducible RNA-binding protein (Cirbp) expression with clinicopathological features including patient prognosis in nasopharyngeal carcinoma (NPC) was investigated. The expression of Cirbp in NPC cell lines and tissue specimens was examined by qRT-PCR or immunohistochemistry (IHC). Immunohistochemistry (IHC) results showed that high Cirbp expression was detected in 61 of 61 non-cancerous nasopharyngeal squamous epithelial biopsies, whereas the significantly reduced expression of Cirbp was observed in NPC specimens. Read More

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https://www.dovepress.com/loss-of-cirbp-expression-is-correl
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http://dx.doi.org/10.2147/CMAR.S211389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662521PMC
July 2019
4 Reads

Research Progress on Long Non-Coding RNA and Radiotherapy.

Med Sci Monit 2019 Aug 3;25:5757-5770. Epub 2019 Aug 3.

Department of Medical Imaging, Nanjing Health Higher Vocational and Technical College, Nanjing, Jiangsu, China (mainland).

d_abstr_R Long non-coding RNAs (lncRNAs), a group of non-protein-coding RNAs longer than 200 nucleotides, are involved in multiple biological and pathological processes, such as proliferation, apoptosis, migration, invasion, angiogenesis, and immune escape. Many studies have shown that lncRNAs participate in the complex network of cancer and play vital roles as oncogenes or tumor-suppressor genes in a variety of cancers. Moreover, recent research has shown that abnormal expression of lncRNAs in malignant tumor cells before and after radiotherapy may participate in the progression of cancers and affect the radiation sensitivity of malignant tumor cells mediated by specific signaling pathways or cell cycle regulation. Read More

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http://dx.doi.org/10.12659/MSM.915647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690404PMC
August 2019
5 Reads

Sinonasal/nasopharyngeal pleomorphic adenoma and carcinoma ex pleomorphic adenoma: a report of 17 surgical cases combined with a literature review.

Cancer Manag Res 2019 17;11:5545-5555. Epub 2019 Jun 17.

Department of Otolaryngology-Head and Neck Surgery, Affiliated Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, People's Republic of China.

The aim of this study was to review demographic data, location, clinical symptoms, therapeutic methods, pathological features and relapse in sinonasal/nasopharyngeal pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA). We conducted a retrospective analysis of 17 patients who were referred to our hospital during a 5-year period from 2013 to 2018. In this series, there were 7 males and 10 females. Read More

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http://dx.doi.org/10.2147/CMAR.S198942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588090PMC
June 2019
5 Reads

MicroRNA-449b-5p suppresses cell proliferation, migration and invasion by targeting TPD52 in nasopharyngeal carcinoma.

J Biochem 2019 Nov;166(5):433-440

Department of Radiotherapy, Hangzhou Cancer Hospital, No. 34 Yanguanxiang, Hangzhou, China.

Nasopharyngeal carcinoma (NPC) is an important type of head and neck malignant cancer with geographical distribution. MicroRNA-449b-5p (miR-449b-5p) is related to the development of various cancers, while its function in NPC remains unknown. The present study aimed to investigate the role and target gene of miR-449b-5p in NPC. Read More

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http://dx.doi.org/10.1093/jb/mvz057DOI Listing
November 2019
1 Read

Circular RNA circ_0008450 upregulates CXCL9 expression by targeting miR-577 to regulate cell proliferation and invasion in nasopharyngeal carcinoma.

Exp Mol Pathol 2019 10 22;110:104288. Epub 2019 Jul 22.

Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar 161000, China. Electronic address:

As a kind of malignant tumor, nasopharyngeal carcinoma (NPC) has attracted increasing attention from researchers. As a member of the circular RNA (circRNA) family, circ_0008450 has been investigated in hepatocellular carcinoma but not in NPC. This study aims to reveal the special biologic role and mechanism of circ_0008450 in NPC. Read More

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http://dx.doi.org/10.1016/j.yexmp.2019.104288DOI Listing
October 2019
3 Reads

CT Evaluation of Squamous Cell Carcinoma of the Nasopharynx.

Curr Health Sci J 2019 Jan-Mar;45(1):79-86. Epub 2019 Mar 31.

"Carol Davila" University of Medicine and Pharmacy, Department of Radiology and Medical Imaging "Colţea" Clinical Hospital, Romania.

Squamous cell carcinoma is the most common type of neoplasia which affects the mucosa of the upper aero-digestive tract. Nasopharyngeal carcinoma is a unique disease with clinical behavior, epidemiology, and histopathology that is different from that of squamous cell carcinomas of the head and neck. For malignant tumors such as SCC, rapid growth may occur even though there are no previous clinical signs. Read More

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http://dx.doi.org/10.12865/CHSJ.45.01.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592665PMC
March 2019
2 Reads