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Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):75-77

Department of Dermatology and Venereology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Transit metastases include metastatic foci of the skin and subcutaneous tissue located between the tumor and the nearest regional lymph node. Although transit metastases have been described for malignant melanoma, some cases of transit metastases have also been reported among primary cutaneous non-melanoma cancers. Treatment of patients with in-transit squamous cell carcinoma (SCC) is a multimodal approach for advanced staging imaging and therapy, including Mohs micrographic surgery, adjuvant radiation, and possibly sentinel lymph node biopsy and immunotherapy or chemotherapy. Read More

Clin Cosmet Investig Dermatol 2022 17;15:1109-1117. Epub 2022 Jun 17.

Department of Hand and Plastic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People's Republic of China.

Background: Cutaneous melanoma (CM) accounts for about 90% of all melanoma cases. HIF-1α overexpression is associated with poor prognosis in many cancers including CM. Hence, we characterized differentially expressed genes (DEGs) in the response of CM cells to normoxia and hypoxia. Read More

Cancers (Basel) 2022 Jun 17;14(12). Epub 2022 Jun 17.

Department of Diagnostic and Interventional Radiology, Eberhard Karls University, Tuebingen University Hospital, Hoppe-Seyler-Straße 3, 72076 Tuebingen, Germany.

Background: This study investigated whether a machine-learning-based combination of radiomics and clinical parameters was superior to the use of clinical parameters alone in predicting therapy response after three months, and overall survival after six and twelve months, in stage-IV malignant melanoma patients undergoing immunotherapy with PD-1 checkpoint inhibitors and CTLA-4 checkpoint inhibitors.

Methods: A random forest model using clinical parameters (demographic variables and tumor markers = baseline model) was compared to a random forest model using clinical parameters and radiomics (extended model) via repeated 5-fold cross-validation. For this purpose, the baseline computed tomographies of 262 stage-IV malignant melanoma patients treated at a tertiary referral center were identified in the Central Malignant Melanoma Registry, and all visible metastases were three-dimensionally segmented ( = 6404). Read More

Int J Cancer 2022 Jun 23. Epub 2022 Jun 23.

Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Germany, and German Cancer Consortium (DKTK), Heidelberg, Germany.

Accurate classification of melanocytic tumors is important for prognostic evaluation, treatment and follow-up protocols of patients. The majority of melanocytic proliferations can be classified solely based on clinical and pathological criteria, however in select cases a definitive diagnostic assessment remains challenging and additional diagnostic biomarkers would be advantageous. We analysed melanomas, nevi, Spitz nevi, and atypical spitzoid tumors using parallel sequencing (exons of 611 genes and 507 gene translocation analysis) and methylation arrays (850k Illumina EPIC). Read More

J Eur Acad Dermatol Venereol 2022 Jun 20. Epub 2022 Jun 20.

Center for Dermatology, Allergology and Dermatosurgery, HELIOS University Hospital Wuppertal, University of Witten/Herdecke, Wuppertal, Germany.

Wien Med Wochenschr 2022 Jun 20. Epub 2022 Jun 20.

Department of Dermatology and Venereology, Medical Faculty, Medical University, 15A V. Aprilov Blvd., 4002, Plovdiv, Bulgaria.

Ann Transl Med 2022 May;10(10):551

Department of Dermatology, Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.

Background: Nail pigmentation can be a clinical manifestation of malignant melanoma and a variety of benign diseases. Nail matrix biopsy for pathologic examination, the gold standard for diagnosis of subungual melanoma, is a painful procedure and may result in nail damage. Therefore, there is a great need for non-invasive methods and long-term follow-up for nail pigmentation. Read More

Front Oncol 2022 1;12:856963. Epub 2022 Jun 1.

Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland.

Malignant melanoma, with its increasing incidence and high potential to form metastases, is one of the most aggressive types of skin malignancies responsible for a significant number of deaths worldwide. However, melanoma also demonstrates a high potential for induction of a specific adaptive anti-tumor immune response being one of the most immunogenic malignancies. Yin Yang 1 (YY1) transcription factor is essential to numerous cellular processes and the regulation of transcriptional and posttranslational modifications of various genes. Read More

Comb Chem High Throughput Screen 2022 Jun 16. Epub 2022 Jun 16.

Department of dermatology, Cangzhou Central Hospital, No. 16 Xinhua Western Road, Cangzhou, 061000 Hebei province, P.R. China.

Objective: Malignant melanoma with gastric cancer is one of the most malignant tumors. However, there have been no reports on the effects of KAI1 and miRNA-633 on the survival and prognosis of patients with malignant melanoma with gastric cancer.

Methods: Fifty patients with malignant melanoma and gastric cancer were collected from October 2017 to December 2019. Read More

J Clin Oncol 2022 Jun 16:JCO2200202. Epub 2022 Jun 16.

Division of Cancer Sciences, The Christie NHS Foundation Trust, The University of Manchester, Manchester, United Kingdom.

Purpose: The first randomized trial of adjuvant treatment with checkpoint inhibitor in stage II melanoma reported a significant reduction in risk of tumor recurrence. This study evaluates two independent data sets to further document survival probabilities for patients with primary stage I and II melanoma.

Patients And Methods: The Central Malignant Melanoma Registry (CMMR) in Germany evaluated 17,544 patients with a primary diagnosis of stage I and II melanoma from 2000 to 2015. Read More

J Cutan Pathol 2022 Jun 15. Epub 2022 Jun 15.

Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Republic of Korea.

Malignant melanoma may rarely exhibit divergent differentiation, in which melanocytic markers may be lost, leading to difficulty in diagnosis. A 64-year-old man recently diagnosed with myelodysplastic syndrome complained of development of a nodule in a melanocytic nevus on his scalp. On histopathologic examination, junctional nevus nests and diffuse cellular infiltrations with a sheet-like growth pattern of pleomorphic epithelioid cells were observed in the upper dermis. Read More

Int J Lab Hematol 2022 Jun 14. Epub 2022 Jun 14.

Department of Internal Medicine and Dermatology, CHU Réunion, Saint Denis, France.

Crit Rev Eukaryot Gene Expr 2022 ;32(3):21-30

Department of Dermatology, China-Japan Union Hospital, Jilin University, 130021 Changchun, China.

Malignant melanoma is one of the most aggressive types of skin cancer. Thus, efficient diagnosis and treatment methods are crucial for advanced melanoma. Circular RNAs (circRNAs) have been regarded as a 'splicing noise' in the past decades. Read More

J Eur Acad Dermatol Venereol 2022 Jun 10. Epub 2022 Jun 10.

Division of Dermatology, Department of Medicine, National University Healthcare System, Singapore, Singapore.

Int J Mol Sci 2022 May 29;23(11). Epub 2022 May 29.

Independent Radiopharmacy Unit, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.

Malignant melanoma (MM) is the most lethal skin cancer. Despite a 4% reduction in mortality over the past few years, an increasing number of new diagnosed cases appear each year. Long-term therapy and the development of resistance to the drugs used drive the search for more and more new agents with anti-melanoma activity. Read More

Cancer Causes Control 2022 Jul 9;33(7):921-928. Epub 2022 Jun 9.

Department of Epidemiology, Brown School of Public Health, Providence, RI, USA.

Purpose: Prior epidemiological studies evaluating the association between fish intake and melanoma risk have been few and inconsistent. Few studies distinguished different types of fish intake with risk of melanoma.

Methods: We examined the associations between intake of total fish and specific types of fish and risk of melanoma among 491,367 participants in the NIH-AARP Diet and Health Study. Read More

Small 2022 Jun 3:e2202558. Epub 2022 Jun 3.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P.R. China.

Sonodynamic therapy (SDT) is garnering considerable attention in cancer treatment due to its non-invasive nature and the potential of spatiotemporal control. However, the high level of glutathione (GSH) in cancer cells can alleviate the SDT-mediated ROS-damages, resulting in a reduced SDT effect. Here, a two-in-one nano-prodrug for photoacoustic imaging-guided enhanced SDT against skin cancers is synthesized. Read More

Dermatopathology (Basel) 2022 May 2;9(2):148-157. Epub 2022 May 2.

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany.

Background: Rhabdoid melanoma is a rare variant of malignant melanoma with characteristic cytomorphologic features. Due to the potential loss of conventional melanocytic markers, histopathologic diagnosis is often challenging. We hypothesize that immunostaining for (PRAME) might have the potential to uncover the melanocytic origin of these dedifferentiated tumors. Read More

Am J Dermatopathol 2022 May 30. Epub 2022 May 30.

Department of Dermatology, The University of Texas at Austin Dell Medical School, Austin, TX.

Abstract: Verrucous malignant melanoma (MM) is a rare variant of melanoma that often presents diagnostic challenges. This case highlights the unique presentation of verrucous MM underlying a cutaneous horn. It is vital for dermatologists to be aware of this potentially benign-appearing variant to be able to diagnose and treat MM early on. Read More

Cancers (Basel) 2022 May 23;14(10). Epub 2022 May 23.

Department of Medicine, Division of Nephrology, University of Ottawa, Ottawa, ON K1H 8L6, Canada.

Background: The use of thiazide diuretics is associated with skin cancer risk; however, whether this applies to all skin cancer types is unclear.

Methods: In this meta-analysis, we searched multiple electronic databases and gray literature up to 10 April 2022, with no language restrictions, to identify relevant randomized controlled trials (RCTs) and non-randomized studies (cohort, case-control) that investigated the association between thiazide diuretics and skin cancer. The primary outcomes of interest were malignant melanoma and non-melanoma skin cancer (basal cell carcinoma [BCC], squamous cell carcinoma [SCC]). Read More

Front Oncol 2022 10;12:905360. Epub 2022 May 10.

Department of Dermatology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

[This corrects the article DOI: 10.3389/fonc.2019. Read More

J Dermatol 2022 May 23. Epub 2022 May 23.

Department of Dermatologic Oncology, National Cancer Center Hospital, Tokyo, Japan.

Nivolumab, a monoclonal antibody against human programmed death 1, was approved for the treatment of melanoma in July 2014 in Japan. Because the Japanese phase II studies (ONO-4538-02, ONO-4538-08) enrolled small numbers of melanoma patients, post-marketing surveillance (PMS; JapicCTI-163 272) was conducted to collect safety data in a larger patient population. We report data for melanoma patients who received nivolumab between July 4, 2014 and February 28, 2017. Read More

Front Immunol 2022 4;13:893086. Epub 2022 May 4.

Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Autoantibodies are found in various pathological conditions such as autoimmune diseases, infectious diseases, and malignant tumors. However their clinical implications have not yet been fully elucidated. Herein, we conducted proteome-wide autoantibody screening and quantification with wet protein arrays consisting of proteins synthesized from proteome-wide human cDNA library (HuPEX) maintaining their three-dimensional structure. Read More

Anticancer Agents Med Chem 2022 May 19. Epub 2022 May 19.

Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

Background: Melanoma is a highly invasive and metastatic malignant tumor originating from melanocytes and is associated with a poor prognosis. Surgical resection and chemotherapy are currently the main therapeutic options for malignant melanoma; however, their efficacy is poor, highlighting the need for the development of new, safe, and effective drugs for the treatment of this cancer.

Objective: To investigate the effects of alantolactone (ALT) on the proliferative, migratory, invasive, and apoptotic ability of malignant melanoma cells and explore its potential anticancer mechanism. Read More

Melanoma Res 2022 May 13. Epub 2022 May 13.

Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Locoregional and distant metastases account for most cases of morbidity and mortality associated with melanoma. In addition, local recurrences of melanoma might be the onset of disseminated disease. Therefore, precise diagnosis and therapy are warranted to minimize morbidity and increase survival in a subset of patients. Read More

Ann Transl Med 2022 Apr;10(8):448

Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Background: Skin cutaneous malignant melanoma (SKCM) is a deadly mutated malignancy that arises from melanocytes in the basal layer of the skin. This study sought to identify effective treatment targets that could serve as prospective therapeutic targets to improve patient outcomes.

Methods: The GSE83583, GSE111766, and GSE104849 data sets from the GPL10558 platform in the Gene Expression Omnibus (GEO) were used in this study. Read More

J Eur Acad Dermatol Venereol 2022 May 15. Epub 2022 May 15.

Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.

Background: SARS-CoV-2 has massively changed the care situation in hospitals worldwide. Although tumour care should not be affected, initial reports from European countries were suggestive for a decrease in skin cancer during the first pandemic wave and only limited data are available thereafter.

Objectives: The aim of this study was to investigate skin cancer cases and surgeries in a nationwide inpatient dataset in Germany. Read More

Cancers (Basel) 2022 Apr 23;14(9). Epub 2022 Apr 23.

Unit of Dermatology, University of Pisa, 56126 Pisa, Italy.

Immune dysregulation, in combination with genetic and epigenetic alterations, induces an excessive proliferation of uncontrolled melanoma cells followed by dissemination of the tumor cells to distant sites, invading organs and creating metastasis. Although immunotherapy, checkpoint inhibitors and molecular targeted therapies have been developed as treatment options for advanced melanoma, there are specific mechanisms by which cancer cells can escape treatment. One of the main factors associated with reduced response to therapy is the ability of residual tumor cells to persist in a dormant state, without proliferation. Read More

J Eur Acad Dermatol Venereol 2022 May 10. Epub 2022 May 10.

Dermatology, National Skin Centre, Singapore.

Background: Populations around the world are rapidly ageing. The profile of skin diseases in the elderly is likely to present unique demands on the healthcare system.

Objectives: To provide current data on the burden of skin diseases in Singaporean patients and identify differences in the pattern of skin diseases between elderly patients and the rest of the population. Read More

Int J Clin Exp Pathol 2022 15;15(4):201-205. Epub 2022 Apr 15.

Department of Dermatology, Wayne State University MI, USA.

Nevoid and myxoid melanoma are rare variants of melanoma; association of the two is a unique finding. Nevoid melanoma is characterized by morphologic resemblance to a nevus, whereas myxoid melanoma demonstrates a basophilic mucinous matrix. We present an atypical case of a melanoma progressing from a nevoid melanocytoma with myxoid changes. Read More