3,411 results match your criteria Malignant Melanoma* Dermatology


Pediatric melanoma: Characterizing 256 cases from the Colorado Central Cancer Registry.

Pediatr Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Dermatology, University of Colorado Hospital, Aurora, Colorado.

Background: Melanoma is a rare diagnosis in the pediatric population. Differences in incidence, presentation, and survival distinguish pediatric melanoma from adult melanoma. In order to improve our understanding of pediatric melanoma, our case series investigates differences in incidence, age of onset, and anatomic site between male and female pediatric melanoma patients in Colorado between 1988 and 2015. Read More

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http://dx.doi.org/10.1111/pde.13747DOI Listing
February 2019

Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation.

Case Rep Dermatol 2019 Jan-Apr;11(1):1-6. Epub 2019 Jan 10.

Department of Dermatology, The Princess Alexandra Hospital NHS Trust, Harlow, United Kingdom.

Surgical excision represents the primary treatment for malignant melanoma. On occasion, however, surgery may not be possible, and a different approach is required. Imiquimod is a Toll-like receptor 7 agonist involved in the activation of the innate immune system. Read More

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http://dx.doi.org/10.1159/000496052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381895PMC
January 2019

Massively Parallel Sequencing Analysis of Benign Melanocytic Nevi.

Histopathology 2019 Feb 21. Epub 2019 Feb 21.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Aims: Melanocytic nevi are benign lesions of the skin or mucosa, which may constitute non-obligate precursors of malignant melanoma, particularly when displaying lentiginous and dysplastic features. Here we sought to interrogate the repertoire of somatic genetic alterations in melanocytic nevi.

Methods And Results: DNA extracted from 12 melanocytic nevi and matching normal tissue were separately microdissected and subjected to targeted massively parallel sequencing targeting ≥300 cancer genes. Read More

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http://dx.doi.org/10.1111/his.13843DOI Listing
February 2019

Late-onset isolated adrenocorticotropic hormone deficiency caused by nivolumab: a case report.

BMC Endocr Disord 2019 Feb 19;19(1):25. Epub 2019 Feb 19.

Internal Medicine 1, Shimane University Faculty of Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan.

Background: Immune checkpoint inhibitors including nivolumab, an anti-programmed cell death protein 1 antibody, are recently developed cancer immunotherapy agents. Immune checkpoint inhibitors are known to cause autoimmune-related side effects including endocrine dysfunctions. However, there are few reports on late-onset isolated adrenocorticotropic hormone (ACTH) deficiency caused by nivolumab. Read More

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http://dx.doi.org/10.1186/s12902-019-0335-xDOI Listing
February 2019

Leukocyte⁻Cancer Cell Fusion-Genesis of a Deadly Journey.

Cells 2019 Feb 18;8(2). Epub 2019 Feb 18.

Department of Dermatology and The Yale Cancer Center, Yale School of Medicine, New Haven, CT 06520-8059, USA.

According to estimates from the International Agency for Research on Cancer, by the year 2030 there will be 22 million new cancer cases and 13 million deaths per year. The main cause of cancer mortality is not the primary tumor itself but metastasis to distant organs and tissues, yet the mechanisms of this process remain poorly understood. Leukocyte⁻cancer cell fusion and hybrid formation as an initiator of metastasis was proposed more than a century ago by the German pathologist Prof. Read More

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http://dx.doi.org/10.3390/cells8020170DOI Listing
February 2019

Mutation Status in Primary, Recurrent, and Metastatic Malignant Melanoma and Its Relation to Histopathological Parameters.

Dermatol Pract Concept 2019 Jan 31;9(1):54-62. Epub 2019 Jan 31.

Second Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece.

Background: mutations are a common finding in malignant melanoma (MM). Nevertheless, apart from their significance as a therapeutic target in advanced melanoma, their prognostic value is still debated.

Objective: To assess mutation status in primary, recurrent, or metastatic MM and its correlations with histopathological findings. Read More

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http://dx.doi.org/10.5826/dpc.0901a13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368075PMC
January 2019

Correlation between blood cell count and outcome of melanoma patients treated with anti-PD-1 antibodies.

Jpn J Clin Oncol 2019 Feb 12. Epub 2019 Feb 12.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Background: Anti-programmed cell death protein 1 monoclonal antibodies (αPD-1mAbs) have been shown to be effective for advanced malignant melanoma. Treatment with αPD-1mAbs can also cause immune-related adverse events (irAEs). However, clinical predictive factors for treatment responses or irAE risk remain unclear. Read More

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http://dx.doi.org/10.1093/jjco/hyy201DOI Listing
February 2019
1 Read

Letter to editor: Surgical-site infection following lymph node excision indicates susceptibility for lymphedema: A retrospective cohort study of malignant melanoma patients.

J Plast Reconstr Aesthet Surg 2019 Jan 15. Epub 2019 Jan 15.

Division of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Piazza Giulio Cesare 11, Bari 70124, Italy.

Following the reading of the original article "Surgical-site infection following lymph node excision indicates susceptibility for lymphedema: A retrospective cohort study of malignant melanoma patients", the authors reviewed the literature for the discussed therapeutic value of complete lymph node dissection (CLND), the major complications and the current treatment for lymphedema. The authors also share their experience and protocol for CLND, and treating lymphedema using lymph node flap transfer and multiple lymphatic-venous anastomoses. Read More

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http://dx.doi.org/10.1016/j.bjps.2018.12.052DOI Listing
January 2019
1 Read

Malignant melanoma incidence among children and adolescents in Texas and SEER 13, 1995-2013.

Pediatr Blood Cancer 2019 Feb 7:e27648. Epub 2019 Feb 7.

Department of Pediatrics, Hematology-Oncology Section, Texas Children's Cancer Center, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.

Background: Epidemiological knowledge and predictors of melanoma among children and adolescents in multiethnic populations are limited.

Procedure: Using data from the Texas Cancer Registry (TCR) and the Surveillance, Epidemiology, and End Results (SEER) 13 database, we identified incident melanoma cases diagnosed at 0-20 years old during 1995-2013 in Texas and the United States, respectively. Using negative binomial regression, associations between demographic factors and melanoma incidence rates (IR) were evaluated by calculating incidence rate ratios (IRR) and 95% confidence intervals (CI). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pbc.27648
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http://dx.doi.org/10.1002/pbc.27648DOI Listing
February 2019
1 Read
2.562 Impact Factor

Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA.

Front Immunol 2019 22;10. Epub 2019 Jan 22.

Institute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.

Robust anti-tumor immunity requires innate as well as adaptive immune responses. We have shown that plasmacytoid dendritic cells develop killer cell-like activity in melanoma cell cocultures after exposure to the infectious but replication-deficient herpes simplex virus 1 (HSV-1) 106S. To combine this innate effect with an enhanced adaptive immune response, the gene encoding human MelanA/MART-1 was inserted into HSV-1 106S via homologous recombination to increase direct expression of this tumor antigen. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00002
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http://dx.doi.org/10.3389/fimmu.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349778PMC
January 2019
4 Reads

Gene Expression and Methylation Analysis in Melanomas and Melanocytes From the Same Patient: Loss of NPM2 Expression Is a Potential Immunohistochemical Marker for Melanoma.

Front Oncol 2018 21;8:675. Epub 2019 Jan 21.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Chuo-ku, Japan.

DNA methylation is considered the primary epigenetic mechanism underlying the development of malignant melanoma. Since DNA methylation can be influenced by environmental factors, it is preferable to compare cancer and normal cells from the same patient. In order to compare the methylation status in melanoma tissues and melanocytes from the same individuals, we employed a novel epidermal sheet cultivation technique to isolate normal melanocytes from unaffected sites of melanoma patients. Read More

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http://dx.doi.org/10.3389/fonc.2018.00675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348333PMC
January 2019

Sentinel lymph node excision with or without preoperative hybrid single-photon emission computed tomography/computed tomography (SPECT/CT) in melanoma: study protocol for a multicentric randomized controlled trial.

Trials 2019 Feb 4;20(1):99. Epub 2019 Feb 4.

Department of Dermatology, Venerology and Allergology, University-Hospital Essen, University of Duisburg-Essen, 45122, Essen, Germany.

Background: Melanoma has become a growing interdisciplinary problem in public health worldwide. According to the World Health Organization, the incidence of melanoma is increasing faster than any other cancer in the world. Because melanoma metastasizes early into the regional lymph nodes, sentinel lymph node excision (SLNE) is included in the current American Joint Committee of Cancer guidelines. Read More

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http://dx.doi.org/10.1186/s13063-019-3197-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360709PMC
February 2019
1 Read

Exploring Differential Connexin Expression across Melanocytic Tumor Progression Involving the Tumor Microenvironment.

Cancers (Basel) 2019 Feb 1;11(2). Epub 2019 Feb 1.

Department of Pathology and Experimental Cancer Research, Semmelweis University, H-1085 Budapest, Hungary.

The incidence of malignant melanoma, one of the deadliest cancers, continues to increase. Here we tested connexin (Cx) expression in primary melanocytes, melanoma cell lines and in a common nevus, dysplastic nevus, and thin, thick, and metastatic melanoma tumor progression series involving the tumor microenvironment by utilizing in silico analysis, qRT-PCR, immunocyto-/histochemistry and dye transfer tests. Primary melanocytes expressed /Cx43, /Cx46 and low levels of /Cx26 and /Cx30. Read More

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http://dx.doi.org/10.3390/cancers11020165DOI Listing
February 2019
1 Read

Serum S100B Levels in Melanoma.

Methods Mol Biol 2019 ;1929:691-700

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Malignant melanoma is a cancer with increasing incidence worldwide with relevant socioeconomic impact. Despite progress in prevention and early detection, it is one of the most lethal forms of skin cancer. Therefore it is urgent need to identify suitable biomarkers in order to improve early diagnosis, precise staging, and prognosis, as well as for therapy selection and monitoring. Read More

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http://link.springer.com/10.1007/978-1-4939-9030-6_43
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http://dx.doi.org/10.1007/978-1-4939-9030-6_43DOI Listing
January 2019
3 Reads

The causes of nail apparatus pigmentation presenting to a melanoma screening clinic a prospective study.

Clin Exp Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Dermatology Unit, Royal Victoria Infirmary, Newcastle Upon Tyne, UK.

Background: Advanced stage primary cutaneous malignant melanoma (PCMM) has a high mortality. PCMM may affect any area of the skin, including the nail apparatus (malignant melanoma or subungual melanoma). Although nail apparatus malignant melanoma (NAMM) is rare, delayed diagnosis carries a poor prognosis. Read More

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http://doi.wiley.com/10.1111/ced.13897
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http://dx.doi.org/10.1111/ced.13897DOI Listing
January 2019
2 Reads

Age as key factor for pattern, timing and extent of distant metastasis in patients with cutaneous melanoma. A study of the German Central Malignant Melanoma Registry.

J Am Acad Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Center for Dermatooncology, Department of Dermatology, Eberhard-Karls-University of Tübingen, Tübingen, Germany.

Background: Melanoma incidence rates rise as people age but the impact of aging on distant metastasis is unclear.

Objective: To investigate how timing, pattern and extent of distant metastasis is influenced by age.

Methods: Analysis of a single-center cohort of 1. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.01.044DOI Listing
January 2019
1 Read

A Case of Acute Exacerbation of Chronic Adrenal Insufficiency Due to Ipilimumab Treatment for Advanced Melanoma.

Am J Case Rep 2019 Jan 25;20:106-110. Epub 2019 Jan 25.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Fukuoka, Japan.

BACKGROUND Ipilimumab is a therapeutic human monoclonal antibody that targets the T-cell inhibitory molecule, cytotoxic T-lymphocyte antigen-4 (CTLA-4), and is classified as an immune checkpoint inhibitor that has been shown to improve prognosis in patients with advanced melanoma. However, several immune-related adverse events have been reported to be associated with ipilimumab Treatment. A case of acute exacerbation of chronic adrenal insufficiency is presented that highlights that glucocorticoid dosage for patients undergoing steroid treatment at the time of ipilimumab treatment has yet to be established. Read More

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https://www.amjcaserep.com/abstract/index/idArt/913021
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http://dx.doi.org/10.12659/AJCR.913021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354724PMC
January 2019
4 Reads

Recurrent vulvar melanoma in a patient with neurofibromatosis and gastrointestinal stromal tumour.

BMJ Case Rep 2019 Jan 20;12(1). Epub 2019 Jan 20.

Oncology, Mater Misericordiae University Hospital, Dublin, Ireland.

We report a case of a 51-year-old woman with neurofibromatosis who presented in 2012 with postmenopausal bleeding. Excision biopsy of a pigmented lesion of the labia minora was consistent with an ulcerated vulvar BRAF wild type malignant melanoma (MM). Initial excision was followed by radical vulvectomy and adjuvant interferon. Read More

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http://dx.doi.org/10.1136/bcr-2018-224744DOI Listing
January 2019
1 Read

Clinicopathologic, misdiagnosis and survival differences between clinically amelanotic melanomas and pigmented melanomas.

J Am Acad Dermatol 2019 Jan 14. Epub 2019 Jan 14.

Pigmented Lesion Clinic and Cutaneous Oncology Program, Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address:

Background: Amelanotic malignant melanoma (AMM) is challenging to diagnose. Clinical risk factors for AMM are not well defined.

Objective: To investigate clinicopathologic, misdiagnosis and survival differences between AMM versus (vs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622193008
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http://dx.doi.org/10.1016/j.jaad.2019.01.012DOI Listing
January 2019
8 Reads
4.449 Impact Factor

Skin Cancer Associated Genodermatoses: A Literature Review.

Acta Derm Venereol 2019 01 17. Epub 2019 Jan 17.

Department of Dermatology and Allergy Centre, Odense University Hospital, DK-5000 Odense, Denmark.

Skin cancer has become the most common type of cancer worldwide as a result of environmental exposure and medical treatments. A small group of patients are genetically predisposed to skin cancer and this article is intended as a diagnostic tool when encountering patients with multiple skin cancer lesions. The disorders are described with clinical characteristics, genetics and management. Read More

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http://dx.doi.org/10.2340/00015555-3123DOI Listing
January 2019
7 Reads

Metastatic melanoma: pretreatment contrast-enhanced CT texture parameters as predictive biomarkers of survival in patients treated with pembrolizumab.

Eur Radiol 2019 Jan 15. Epub 2019 Jan 15.

Department of Radiology, Reims University Hospital, 45 rue Cognacq-jay, 51092, Reims, France.

Purpose: To determine whether texture analysis features on pretreatment contrast-enhanced computed tomography (CT) images can predict overall survival (OS) and progression-free survival (PFS) in patients with metastatic malignant melanoma (MM) treated with an anti-PD-1 monoclonal antibody, pembrolizumab.

Materials And Methods: This institutional-approved retrospective study included 31 patients with metastatic MM treated with pembrolizumab. Texture analysis of 74 metastatic lesions was performed on CT scanners obtained within 1 month before treatment. Read More

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http://dx.doi.org/10.1007/s00330-018-5933-xDOI Listing
January 2019
1 Read

Expression of Neural Crest Markers GLDC and ERRFI1 is Correlated with Melanoma Prognosis.

Cancers (Basel) 2019 Jan 11;11(1). Epub 2019 Jan 11.

Skin Cancer Unit, German Cancer Research Center (DKFZ), D-69121 Heidelberg, Germany.

Regulation of particular genes during the formation of neural crest (NC) cells is also described during progression of malignant melanoma. In this context, it is of paramount importance to develop neural crest models allowing the identification of candidate genes, which could be used as biomarkers for melanoma prognosis. Here, we used a human induced Pluripotent Stem Cells (iPSC)-based approach to present novel NC-associated genes, expression of which was upregulated in melanoma. Read More

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http://www.mdpi.com/2072-6694/11/1/76
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http://dx.doi.org/10.3390/cancers11010076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356846PMC
January 2019
8 Reads

Long noncoding RNA X-inactive specific transcript promotes malignant melanoma progression and oxaliplatin resistance.

Melanoma Res 2019 Jan 11. Epub 2019 Jan 11.

Department of Dermatology.

Long noncoding RNA X-inactive specific transcript (XIST) was confirmed to participate in the development of many cancers. However, the function of XIST in malignant melanoma (MM) remained largely unknown. In the current study, we found that the XIST expression level was upregulated in MM tissues and cell lines. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000560DOI Listing
January 2019
1 Read
2.282 Impact Factor

Translational control mechanisms in cutaneous malignant melanoma: the role of eIF2α.

J Transl Med 2019 Jan 11;17(1):20. Epub 2019 Jan 11.

Department of Basic Medical Sciences Neurosciences and Sense Organs, University of Bari, Bari, Italy.

Background: Melanoma cells develop adaptive responses in order to cope with particular conditions of tumor microenvironment, characterized by stress conditions and deregulated proliferation. Recently, the interplay between the stress response and the gene expression programs leading to metastatic spread has been reported.

Methods: We evaluated levels and localization of eIF2α/peIF2α in V600BRAF and wtBRAF metastatic melanoma cell lines by means of western blot and confocal microscopy analyses. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-019-1772-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329103PMC
January 2019
5 Reads
3.930 Impact Factor

Histogenesis of cutaneous malignant melanoma: The vast majority do not develop from melanocytic nevus but arise de novo as melanoma in situ.

Authors:
Toshiaki Saida

J Dermatol 2019 Feb 11;46(2):80-94. Epub 2019 Jan 11.

Shinshu University, Matsumoto, Japan.

It has been considered that most cutaneous malignant melanomas arise from pre-existing melanocytic nevus. Many clinical and histopathological studies seem to support this concept. Dysplastic nevus originally proposed by Clark's group is a key entity of the intermediate lesion between benign nevus and melanoma. Read More

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http://doi.wiley.com/10.1111/1346-8138.14737
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http://dx.doi.org/10.1111/1346-8138.14737DOI Listing
February 2019
6 Reads

Vitiligo-like depigmentation in oncology patients treated with immunotherapies for nonmelanoma metastatic cancers.

Clin Exp Dermatol 2019 Jan 7. Epub 2019 Jan 7.

Department of Dermatology, Westmead Hospital, Sydney, Australia.

Vitiligo-like depigmentation (VLD) is a characteristic cutaneous event described in patients with metastatic malignant melanoma receiving treatment with immune checkpoint inhibitors. We report the onset of VLD in three patients with other cancer types (cholangiocarcinoma, renal cell carcinoma and squamous cell carcinoma) following treatment with immunotherapy (combination pembrolizumab and nivolumab for the first, and pembrolizumab for the other two cancer types). Cases of VLD have not been reported previously in patients treated for any of these cancers, to our knowledge. Read More

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http://dx.doi.org/10.1111/ced.13867DOI Listing
January 2019
1 Read

Time trends and age-period-cohort analysis of cutaneous malignant melanoma incidence rates in the Romagna Region (northern Italy), 1986-2014.

Melanoma Res 2019 Jan 4. Epub 2019 Jan 4.

Romagna Cancer Registry.

After a long-term increase, the incidence of cutaneous malignant melanoma has stabilized recently or even decreased in several populations of North-western Europe, USA, Canada, Australia and New Zealand, but not in southern Europe. The incidence trends of primary invasive cutaneous malignant melanoma (International Classification of Diseases, 10th revision, codes C43.0-C43. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000570DOI Listing
January 2019
7 Reads

Robotic inguinal lymph node dissection for melanoma: a novel approach to a complicated problem.

J Robot Surg 2019 Jan 3. Epub 2019 Jan 3.

Division of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124, Bari, Italy.

Following the interesting reading of the article "Robotic inguinal lymph node dissection for melanoma: a novel approach to a complicated problem", the authors review the pros and cons of a minimally invasive technique for lymph node dissection, the consequences of complete lymph node dissection and the possible treatments for lymphedema, such as lymph node flap transfer and multiple lymphatic-venous anastomoses. The authors also review the possible benefits of applying the robotic technique to anatomical sites other than the inguinal one. Read More

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http://dx.doi.org/10.1007/s11701-018-00906-xDOI Listing
January 2019
2 Reads

Vitiligo-like lesions in a patient treated with nivolumab for renal cell carcinoma.

Medicine (Baltimore) 2018 Dec;97(52):e13810

Skin Cancer Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), IRCCS, Meldola.

Rationale: The introduction of immune check-point inhibitors (ICIs) in the treatment of solid neoplasms is associated with the need to know and manage a new type of side effects that are commonly defined immune-mediated adverse events. Dermatologic immune-mediated adverse events are relatively common. Vitiligo-like lesions, defined as hypopigmented skin lesions, have already been associated with the use of ICIs in particular in patients with malignant melanoma, probably due to a common autoimmune mechanism against both melanoma cells and normal melanocytes. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812280-0004
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http://dx.doi.org/10.1097/MD.0000000000013810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314787PMC
December 2018
3 Reads

Pyrroline-5-carboxylate reductase 1 promotes cell proliferation via inhibiting apoptosis in human malignant melanoma.

Cancer Manag Res 2018 27;10:6399-6407. Epub 2018 Nov 27.

Department of Dermatology, Ningbo No.2 Hospital, Ningbo, Zhejiang, China,

Introduction: Human malignant melanoma (MM) is a highly malignant tumor of cutaneous melanocytes with a fast progression. We investigated the cellular effects of pyrroline-5- carboxylate reductase 1 (PYCR1) in the MM cell lines, A375 and M14.

Methods: Cell Counting Kit-8 assay, transwell assay, and flow cytometry analysis were performed to evaluate the proliferation, migration and apoptosis of MM cell lines, respectively. Read More

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https://www.dovepress.com/pyrroline-5-carboxylate-reductase-
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http://dx.doi.org/10.2147/CMAR.S166711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267761PMC
November 2018
7 Reads

Characteristics of Xeroderma Pigmentosum in Japan: Lessons From Two Clinical Surveys and Measures for Patient Care.

Photochem Photobiol 2019 Jan 28;95(1):140-153. Epub 2018 Dec 28.

Division of Neurology, Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan.

Xeroderma pigmentosum (XP) is a rare autosomal recessive hereditary disease caused by deficiency in repair of DNA lesions generated by ultraviolet radiation and other compounds. Patients with XP display pigmentary change and numerous skin cancers in sun-exposed sites, and some patients show exaggerated severe sunburns even upon minimum sun exposure as well as neurological symptoms. We conducted a nationwide survey for XP since 1980. Read More

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http://dx.doi.org/10.1111/php.13052DOI Listing
January 2019
1 Read

Multiple Primary Cutaneous Melanomas in a Bulgarian Patient: The Possible Role of One Step Melanoma Surgery (OSMS) As the Most Adequate Treatment Approach!

Open Access Maced J Med Sci 2018 Nov 21;6(11):2155-2160. Epub 2018 Nov 21.

Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev Nr 79, Sofia, Bulgaria.

Background: Simultaneous occurrence of multiple primary melanomas is a rare, however possible phenomenon, and it is believed that older, male, white, Atypical Mole Syndrome carriers (sporadic and familial) are part of the possible risk factors for its occurrence. In these patients, it is possible to observe involutional changes or (partial/complete) regression of melanocytic lesions, which are likely to be caused by the generation of a spontaneous immune reaction against specific tumour antigens.

Case Report: A 58-year-old male patient is presented with two melanocytic lesions located in the right clavicle (subclavicular area) and left the scapular area that meets clinically and dermatoscopically the requirements for malignant melanoma. Read More

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http://dx.doi.org/10.3889/oamjms.2018.487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290406PMC
November 2018
1 Read

Eruptive melanocytic nevi in a patient with Parkinson disease treated by carbidopa-levodopa.

JAAD Case Rep 2019 Jan 4;5(1):21-23. Epub 2018 Dec 4.

Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126183029
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http://dx.doi.org/10.1016/j.jdcr.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280631PMC
January 2019
5 Reads

The national burden of inpatient dermatology in adults.

J Am Acad Dermatol 2019 Feb 13;80(2):425-432. Epub 2018 Dec 13.

George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Dermatology, Children's National Health System, Washington, DC. Electronic address:

Background: Management of inpatient skin disease represents a unique subspecialty within dermatology.

Objective: To assess the national burden of inpatient dermatology in adults.

Methods: Using the 2014 National Inpatient Sample, we performed a retrospective cohort study of adults hospitalized for dermatologic conditions. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.06.070DOI Listing
February 2019
1 Read

Pushing and loss of elastic fibers are highly specific for melanoma and rare in melanocytic nevi.

Arch Dermatol Res 2019 Mar 13;311(2):99-107. Epub 2018 Dec 13.

Dermatology Department, Inselspital Bern University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.

The histopathological differentiation of melanocytic nevi from malignant melanoma (MM) is based on well-known criteria, and is straightforward in the vast majority of cases. However, there are few cases of melanocytic lesions (ML), the diagnosis of which is very challenging or even impossible. Here we have studied several morphological characteristics with particular focus on elastic fibers (EF) to identify features, helpful for the distinction between nevi and MM. Read More

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http://link.springer.com/10.1007/s00403-018-1885-x
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http://dx.doi.org/10.1007/s00403-018-1885-xDOI Listing
March 2019
10 Reads

ALK expression favorably impacts the prognosis of -mutated metastatic melanomas.

Oncol Lett 2018 Dec 9;16(6):7091-7096. Epub 2018 Oct 9.

Department of Molecular Biotechnology and Health Sciences, Center for Experimental Research and Medical Studies, University of Torino, I-10126 Torino, Italy.

Recent studies reported the expression of anaplastic lymphoma kinase (ALK) in malignant melanomas. The aim of this study was to investigate whether ALK expression is associated with specific clinical and molecular characteristics of melanoma metastases, and to evaluate its correlation with survival outcomes. Seventy-one patients with metastatic melanoma were investigated. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9560
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http://dx.doi.org/10.3892/ol.2018.9560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256323PMC
December 2018
7 Reads
0.987 Impact Factor

Eruptive cherry angiomas and skin melanoma: a fortuitous association?

Melanoma Res 2018 Dec 12. Epub 2018 Dec 12.

Section of Dermatology and Infectious Diseases, Department of Medical Sciences.

The aim of the study was to assess the association between eruptive cherry angiomas (CAs) and malignant melanoma (MM). Secondary objectives included investigating (i) this association in different age subgroups, and (ii) the association of eruptive CAs with other variables such as malignant tumours, in general, and immunosuppressive treatments. This cross-sectional study involved all patients referred to the outpatient Dermatology-Oncology Units of the universities of Ferrara and Bologna, Italy, and submitted to total body skin examination. Read More

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http://Insights.ovid.com/crossref?an=00008390-900000000-9920
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http://dx.doi.org/10.1097/CMR.0000000000000563DOI Listing
December 2018
2 Reads

Cutaneous malignant melanoma of the oral cavity following skin graft reconstruction: Case report.

Head Neck 2019 Feb 7;41(2):E26-E29. Epub 2018 Dec 7.

Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Malignant melanomas on skin graft recipient sites are rare, with few cases reported in the literature.

Methods: We present a case report of a patient with recurrent cutaneous melanoma in the grafted anterolateral thigh flap of the tongue.

Results: A patient underwent hemiglossectomy with free flap reconstruction for squamous cell carcinoma of the tongue. Read More

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http://dx.doi.org/10.1002/hed.25417DOI Listing
February 2019
13 Reads

Hepatic Endothelial Notch Activation Protects against Liver Metastasis by Regulating Endothelial-Tumor Cell Adhesion Independent of Angiocrine Signaling.

Cancer Res 2019 Feb 10;79(3):598-610. Epub 2018 Dec 10.

Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.

: The interaction of tumor cells with organ-specific endothelial cells (EC) is an important step during metastatic progression. Notch signaling in organ-specific niches has been implicated in mediating opposing effects on organotropic metastasis to the lungs and the liver, respectively. In this study, we scrutinized the role of endothelial Notch activation during liver metastasis. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-1752DOI Listing
February 2019
1 Read

Giant congenital facial melanocytic nevus.

Oman J Ophthalmol 2018 Sep-Dec;11(3):265-266

Dr. R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Giant Congenital Melanocytic Nevus (GCMNs) is mostly reported in area of trunk followed by limbs and head. Their incidence is <1:20,000 newborns It derives attention due to its association with malignant melanoma.The risk of developing malignant melanoma is between 5 to 10%. Read More

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http://dx.doi.org/10.4103/ojo.OJO_216_2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219340PMC
December 2018
9 Reads

Management Decisions Made by Physician Assistants and Nurse Practitioners in Cutaneous Malignant Melanoma Patients: Impact of a 31-Gene Expression Profile Test

J Drugs Dermatol 2018 Nov;17(11):1220-1223

Importance: The 31 gene-expression profiling test (31-GEP) has been shown to provide useful prognostic information in patients with cutaneous melanoma. The test dichotomizes patients into lower risk (Class 1) or higher risk (Class 2) for melanoma metastasis. Previous studies have demonstrated the clinical utility of the test in impacting dermatologists’ management decisions. Read More

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November 2018
10 Reads

Cutaneous Melanoma-A Review in Detection, Staging, and Management.

Hematol Oncol Clin North Am 2019 Feb;33(1):25-38

Department of Dermatology, Brigham and Women's Hospital, 41 Avenue Louis Pasteur, Room 319, Boston, MA 02115, USA; Melanoma Program, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA. Electronic address:

Melanoma is an increasingly common cancer in the United States, although mortality has likely stabilized. Diagnosis relies on a skilled practitioner with the aid of dermoscopy and initial local surgical management is a mainstay of treatment. Recent changes in staging emphasize continued use of sentinel lymph node biopsy to aid in prognostication although routine complete lymph node dissection has fallen out of favor. Read More

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http://dx.doi.org/10.1016/j.hoc.2018.09.005DOI Listing
February 2019
15 Reads

Xanthogranulomatous reaction to trametinib for metastatic malignant melanoma.

Cutis 2018 Oct;102(4):283-286

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Trametinib, a mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor, has demonstrated great promise in treating metastatic melanoma associated with BRAF V600E and V600K mutations; however, it also is highly associated with cutaneous adverse events (AEs). As both BRAF and MEK inhibitors become increasingly used to treat malignant melanoma, it is important to better characterize these AEs so that we can manage them. Herein, we present a case of a 66-year-old man who developed erythematous scaly papules on the face and bilateral upper extremities after beginning therapy with trametinib. Read More

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October 2018
9 Reads

Case of malignant melanoma responding to dacarbazine following nivolumab.

Dermatol Ther 2018 Nov 28:e12791. Epub 2018 Nov 28.

Department of Dermatology, Hiroshima University Hospital, Hiroshima, Japan.

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http://dx.doi.org/10.1111/dth.12791DOI Listing
November 2018
1 Read

NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway.

Braz J Med Biol Res 2018 Nov 23;52(1):e7952. Epub 2018 Nov 23.

Department of Dermatology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Malignant melanoma is an aggressive skin cancer with a high mortality rate. Nucleolar protein 14 (NOP14) has been implicated in cancer development. However, the role of NOP14 in malignant melanoma progression remains largely unclear. Read More

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http://dx.doi.org/10.1590/1414-431X20187952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262753PMC
November 2018
1 Read

Invasiveness-triggered state transition in malignant melanoma cells.

J Cell Physiol 2019 May 27;234(5):5354-5361. Epub 2018 Nov 27.

Institute for Biomedical Sciences of Pain, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

Cancer cells are considered to have high morphological heterogeneity in human melanoma tissue. Here, we report that epithelial cancer cells are dominant in different development stages of human melanoma tissues. The cellular and molecular mechanisms that maintain melanoma cells in the epithelial state are further investigated in the A2058 cell line. Read More

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http://dx.doi.org/10.1002/jcp.27405DOI Listing
May 2019
1 Read
3.839 Impact Factor

Multifunctional Nanoparticle Approach for Targeting Melanoma.

J Investig Dermatol Symp Proc 2018 Dec;19(2):S89-S90

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Malignant melanoma is the most aggressive and lethal form of skin cancer with an increasing incidence worldwide. In the past 5 years, the Food and Drug Administration has approved six targeted therapies or immunotherapies for the treatment of metastatic melanoma (Chapman et al., 2011; Falchook et al. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10870024183001
Publisher Site
http://dx.doi.org/10.1016/j.jisp.2018.09.011DOI Listing
December 2018
11 Reads

Tackling malignant melanoma epigenetically: histone lysine methylation.

Clin Epigenetics 2018 Nov 22;10(1):145. Epub 2018 Nov 22.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Post-translational histone modifications such as acetylation and methylation can affect gene expression. Histone acetylation is commonly associated with activation of gene expression whereas histone methylation is linked to either activation or repression of gene expression. Depending on the site of histone modification, several histone marks can be present throughout the genome. Read More

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http://dx.doi.org/10.1186/s13148-018-0583-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249913PMC
November 2018
11 Reads

NFAT1 enhances the effects of tumor-associated macrophages on promoting malignant melanoma growth and metastasis.

Biosci Rep 2018 Dec 18;38(6). Epub 2018 Dec 18.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, P.R. China

Tumor-associated macrophages (TAMs) play substantial roles in tumor growth, invasion, and metastasis. Nuclear factor of activated T cell (NFAT1) has been shown to promote melanoma growth and metastasis We herein aim to investigate whether NFAT1 is capable to promote melanoma growth and metastasis by influencing TAM properties. Melanoma-conditioned TAMs were obtained from human monocytes after incubation with conditioned medium from A375 cell culture. Read More

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http://dx.doi.org/10.1042/BSR20181604DOI Listing
December 2018
7 Reads