3,648 results match your criteria Malignant Melanoma* Dermatology


Emerging functions and clinical prospects of connexins and pannexins in melanoma.

Biochim Biophys Acta Rev Cancer 2020 May 24:188380. Epub 2020 May 24.

CellCOM Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña, Xubias de Arriba, 84, 15006 A Coruña, Spain. Electronic address:

Cellular communication through gap junctions and hemichannels formed by connexins and through channels made by pannexins allows for metabolic cooperation and control of cellular activity and signalling. These channel proteins have been described to be tumour suppressors that regulate features such as cell death, proliferation and differentiation. However, they display cancer type-dependent and stage-dependent functions and may facilitate tumour progression through junctional and non-junctional pathways. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188380DOI Listing

The association between smoking and risk of skin cancer: a meta-analysis of cohort studies.

Cancer Causes Control 2020 May 27. Epub 2020 May 27.

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita-shi, Osaka, 565-0871, Japan.

Purpose: The association between smoking and the risk of skin cancers has been studied without reaching consistent findings. This study aims to assess this association through an updated meta-analysis of cohort studies.

Methods: We retrieved cohort studies that investigated the temporal association between smoking and the risk of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM). Read More

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http://dx.doi.org/10.1007/s10552-020-01319-8DOI Listing

Co-delivery of Dacarbazine and All-Trans Retinoic Acid (ATRA) Using Lipid Nanoformulations for Synergistic Antitumor Efficacy Against Malignant Melanoma.

Nanoscale Res Lett 2020 May 19;15(1):113. Epub 2020 May 19.

Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.

Malignant melanoma is a highly aggressive skin cancer responsible for 80% of mortality, and the overall median survival in patients with metastatic melanoma is only 6-9 months. Combination treatment through the simultaneous administration of dual drugs in a single nanocarrier has been demonstrated to be elegant and effective in combatting cancer. Herein, we employ a combination therapy based on dacarbazine (DBZ), FDA approved drug for melanoma and all-trans retinoic acid (ATRA), promising anticancer agents loaded on lipid nanoformulations (RD-LNF) as a new treatment strategy for malignant melanoma. Read More

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http://dx.doi.org/10.1186/s11671-020-3293-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237551PMC

An Analysis of Biopsies for Suspected Skin Cancer at a Tertiary Care Dermatology Clinic in the Western Cape Province of South Africa.

J Skin Cancer 2020 27;2020:9061532. Epub 2020 Jan 27.

Division of Dermatology, Department of Medicine, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, South Africa.

Background: Skin cancer is a growing health concern worldwide. It is the most common malignancy in South Africa and places a large burden on the public healthcare sector. There is a paucity of published scientific data on skin cancer in South Africa. Read More

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http://dx.doi.org/10.1155/2020/9061532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204328PMC
January 2020

Higher methylation subtype of malignant melanoma and its correlation with thicker progression and worse prognosis.

Cancer Med 2020 May 14. Epub 2020 May 14.

Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Malignant melanoma (MM) is the most life-threatening disease among all skin malignancies, and recent genome-wide studies reported BRAF, RAS, and NF1 as the most frequently mutated driver genes. While epigenetic aberrations are known to contribute to the oncogenic activity seen in various cancers, their role in MM has not been fully investigated. To investigate the role of epigenetic aberrations in MM, we performed genome-wide DNA methylation analysis of 51 clinical MM samples using Infinium 450k beadarray. Read More

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http://dx.doi.org/10.1002/cam4.3127DOI Listing

Circular RNA: a novel potential biomarker for skin diseases.

Pharmacol Res 2020 May 10:104841. Epub 2020 May 10.

Department of Dermatology, The Second Hospital of Dalian Medical University, Dalian, China; Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, China. Electronic address:

Circular RNA (circRNA) has been classified as noncoding RNA with a covalent closed continuous loop, the 3'and 5' ends of which are normally joined together to increase its own stability. More recently, circRNA has been shown to encode proteins and may be involved in the regulation of gene transcription. This provides more evidence for the involvement of circRNA in disease progression. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104841DOI Listing

Preputial melanoma.

Wien Med Wochenschr 2020 May 7. Epub 2020 May 7.

Onkoderma, Policlinic for Dermatology, Venereology and Dermatologic Surgery, General Skobelev 26, 1606, Sofia, Bulgaria.

Background: Melanomas of the glans penis, prepuce, and the corpus of the penis account for less than 1% of all melanoma cases. Due to this rarity, there is currently no standard treatment approach.

Case Description: We present the case of a 59-year-old patient with tumorous formations in the prepuce area. Read More

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http://dx.doi.org/10.1007/s10354-020-00751-4DOI Listing

Clinical significance of lncRNA MIR31HG in melanoma.

Authors:
H-L Xu F-Z Tian

Eur Rev Med Pharmacol Sci 2020 Apr;24(8):4389-4395

Department of Dermatology, People's Hospital of Juye County, Heze, China.

Objective: The aim of this study was to explore the expression of long non-coding RNA (lncRNA) MIR31HG in malignant melanoma (MM), and to investigate its clinical significance.

Patients And Methods: The quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was used to detect the expression of lncRNA MIR31HG in MM tissues and cells. The relationship between lncRNA MIR31HG expression and the clinicopathological characteristics was analyzed. Read More

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http://dx.doi.org/10.26355/eurrev_202004_21020DOI Listing

Metastatic Melanoma With Sebocyte-Like Melanocytes and Widespread Visceral Involvement.

Dermatol Pract Concept 2020 20;10(2):e2020045. Epub 2020 Apr 20.

Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://dx.doi.org/10.5826/dpc.1002a45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190555PMC

Immunohistochemical Evaluation and Clinicopathological Correlation of Mer and Axl Tyrosine Kinase TAM Receptors in Cutaneous Melanoma.

Dermatol Pract Concept 2020 3;10(2):e2020029. Epub 2020 Apr 3.

Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background: Malignant melanoma (MM) is potentially the most dangerous form of skin tumor. In the last few years, the so-called TAM receptors, a unique family of tyrosine kinase (TK) receptors, have become increasingly important.

Objectives: To evaluate Mer and Axl TAM receptor expression to find clinicopathological features that could explain the biological behavior of MM. Read More

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http://dx.doi.org/10.5826/dpc.1002a29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190557PMC

A twelve-gene signature for survival prediction in malignant melanoma patients.

Ann Transl Med 2020 Mar;8(6):312

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Background: Melanoma is defined as a highly mutational heterogeneous disease containing numerous alternations of the molecule. However, due to the phenotypically and genetically heterogeneity of malignant melanoma, conventional clinical characteristics remain restricted or limited in the ability to accurately predict individual outcomes and survival. This study aimed to establish an accurate gene expression signature to predict melanoma prognosis. Read More

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http://dx.doi.org/10.21037/atm.2020.02.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186619PMC

Introducing teledermoscopy of possible skin cancers in general practice in Southern Denmark.

Fam Pract 2020 Apr 29. Epub 2020 Apr 29.

Audit Project Odense, Research Unit of General Practice, University of Southern Denmark, Odense.

Background: The increasing incidence of skin cancers poses a burden to health care systems. General practitioners (GPs) play an important role in triaging these diseases and referring relevant patients to specialists. It is challenging to distinguish benign from malignant skin lesions, and GPs may benefit from diagnostic support from teledermoscopy (TD). Read More

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http://dx.doi.org/10.1093/fampra/cmaa041DOI Listing

Primary Resistance to PD-1-Based Immunotherapy-A Study in 319 Patients with Stage IV Melanoma.

Cancers (Basel) 2020 Apr 22;12(4). Epub 2020 Apr 22.

Center for Dermatooncology, Department of Dermatology, Eberhard Karls University of Tuebingen, 72076 Tuebingen, Germany.

Background: Primary resistance to immunotherapy can be observed in approximately 40-65% of the stage IV melanoma patients treated with immune checkpoint inhibitors. A minority of the patients receive a second-line therapy, and the clinical benefit is small.

Patients And Methods: Stage IV melanoma patients treated with first-line PD-1-based immunotherapy between January 2015 and December 2018 were investigated. Read More

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http://dx.doi.org/10.3390/cancers12041027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226601PMC

Epitope competition and neutralizing antidrug antibodies: immune monitoring of antiprogrammed death-1 therapies and lessons learned from natalizumab.

Br J Dermatol 2020 Apr 22. Epub 2020 Apr 22.

Department of Dermatology and Allergology, Paracelsus Medical University, Salzburg, Austria.

We read with interest the BJD online publication by Gambichler and colleagues about a decline of programmed death (PD)-1+ circulating T regulatory cells (Tregs) predicting clinical outcome in anti-PD-1 therapy. The study highlights the potential and importance of immune monitoring in anti-PD-1 checkpoint therapy in malignant melanoma. However, their conclusion about anti-PD-1 antibody treatment effecting a decline of PD-1 Tregs is misleading. Read More

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http://dx.doi.org/10.1111/bjd.19137DOI Listing

Successful Treatment of a Patient with anti-PD1 Antibody-Resistant Advanced Mucosal Melanoma with Nivolumab, Ipilimumab plus Denosumab Combination Therapy.

Case Rep Oncol 2020 Jan-Apr;13(1):271-275. Epub 2020 Mar 24.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Since the incidence of mucosal melanoma is higher in the Japanese population compared to Caucasians, and since mucosal melanoma possesses a lower mutation burden compared to cutaneous melanoma, the efficacy of anti-PD1 antibody (Ab) monotherapy for mucosal melanoma is limited. Therefore, other targeting molecules that enhance the anti-tumor effects of immune checkpoint inhibitors are needed. In this report, we present a case with anti-PD1 Ab-resistant recurrent malignant melanoma of the nasal cavity successfully treated with nivolu-mab, ipilimumab plus denosumab combination therapy. Read More

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http://dx.doi.org/10.1159/000506327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154272PMC

Application and challenge of reflectance confocal microscopy in the diagnosis of pigmented nevus.

Skin Res Technol 2020 Apr 6. Epub 2020 Apr 6.

Department of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, China.

Objective: To investigate the application and challenge of reflectance confocal microscopy (RCM) in the diagnosis of pigmented nevus.

Method: A total of 997 patients with clinical diagnosis of pigmented nevus were included in the study, and RCM imaging was performed on the lesion of each patient. A biopsy was performed in 78 of these patients for histological diagnosis. Read More

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http://dx.doi.org/10.1111/srt.12854DOI Listing

A case of metastatic malignant melanoma in congenital systemic dermal melanocytosis.

Indian J Dermatol Venereol Leprol 2020 May-Jun;86(3):308-311

Department of Dermatology, School of Medicine, Keimyung University, Daegu, Korea.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_747_19DOI Listing

Cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis.

Case Rep Gastroenterol 2020 Jan-Apr;14(1):103-109. Epub 2020 Feb 25.

Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Although most immune-related adverse events (irAEs) secondary to immune checkpoint inhibitors can be managed with immunosuppressive therapies; they can induce reactivation of infectious diseases, including cytomegalovirus (CMV). Here, we show a case of CMV enterocolitis during steroid therapy for an irAE. A 77-year-old man with unresectable malignant melanoma was treated with ipilimumab. Read More

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http://dx.doi.org/10.1159/000506186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098339PMC
February 2020

Intake of Furocoumarins and Risk of Skin Cancer in 2 Prospective US Cohort Studies.

J Nutr 2020 Mar 28. Epub 2020 Mar 28.

Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.

Background: In prior studies, higher citrus consumption was associated with higher risk of cutaneous malignant melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). Furocoumarins, compounds with phototoxicity and photocarcinogenicity in citrus, may be responsible for the association.

Objectives: The objective of the study was to investigate the association between furocoumarin intake and skin cancer risk. Read More

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http://dx.doi.org/10.1093/jn/nxaa062DOI Listing

Drug repurposing and rediscovery: Design, synthesis and preliminary biological evaluation of 1-arylamino-3-aryloxypropan-2-ols as anti-melanoma agents.

Bioorg Med Chem 2020 May 3;28(9):115404. Epub 2020 Mar 3.

Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China. Electronic address:

Malignant melanoma (MM) presents as the highest morbidity and mortality type in skin cancer. Herein, inspired by the previously reported anti-melanoma effect of propranolol, a widely applied β adrenergic receptor antagonist as cardiovascular drug, we set out to exploit its potential as anti-melanoma therapy based on the drug repurposing strategy. Structural optimization of propranolol yielded 5m, which exhibits dramatically improved potency on human melanoma cell growth (1. Read More

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http://dx.doi.org/10.1016/j.bmc.2020.115404DOI Listing

Protein Expression in Metastatic Melanoma and the Link to Disease Presentation in a Range of Tumor Phenotypes.

Cancers (Basel) 2020 Mar 24;12(3). Epub 2020 Mar 24.

Clinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University, 221 84 Lund, Sweden.

Malignant melanoma is among the most aggressive skin cancers and it has among the highest metastatic potentials. Although surgery to remove the primary tumor is the gold standard treatment, once melanoma progresses and metastasizes to the lymph nodes and distal organs, i.e. Read More

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http://dx.doi.org/10.3390/cancers12030767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140007PMC

Immunologic Characteristics of Nonmelanoma Skin Cancers: Implications for Immunotherapy.

Am Soc Clin Oncol Educ Book 2020 Mar;40:1-10

Division of Medical Oncology, University of Washington, Seattle, WA.

In this review, we summarize the immunology of nonmelanoma skin cancers (NMSCs) and the clinical data with immunotherapy in this heterogeneous group of cancers that include basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (CSCC), and Merkel cell carcinoma (MCC). NMSCs are exceedingly common, and their treatment consumes substantial health care resources. Annual global mortality from NMSCs is comparable to that from malignant melanoma. Read More

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http://dx.doi.org/10.1200/EDBK_278953DOI Listing

PD-L1 expression in malignant melanomas of the skin and gastrointestinal tract.

Oncol Lett 2020 Mar 21;19(3):2481-2488. Epub 2020 Jan 21.

Department of Dermatology, Nippon Medical School, Tokyo 113-8603, Japan.

Gastrointestinal melanoma (GM) is a rare but aggressive type of malignant melanoma arising in the gastrointestinal tract. An anti-programmed cell death protein 1 (PD-1) antibody markedly improves prognosis in patients with melanoma. However, little is known regarding the expression of immune-oncology biomarkers in GM compared with skin melanoma (SM), especially in the Asian population. Read More

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http://dx.doi.org/10.3892/ol.2020.11325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039169PMC

Ubiquitination of P53 by E3 ligase MKRN2 promotes melanoma cell proliferation.

Oncol Lett 2020 Mar 8;19(3):1975-1984. Epub 2020 Jan 8.

Department of Dermatology, Xuzhou Central Hospital, Affiliated to Southeast University, Xuzhou, Jiangsu 221009, P.R. China.

Melanoma is the most aggressive and lethal type of skin cancer. The aim of the present study was to illustrate the molecular mechanism of makorin ring finger protein 2 (MKRN2) control of melanoma cell proliferation. The expression level of MKRN2 was detected in human malignant melanoma cell lines by immunoblotting and reverse transcription-quantitative PCR. Read More

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http://dx.doi.org/10.3892/ol.2020.11261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039176PMC

Association of Gender with Survival in Melanoma In Situ of the Head and Neck: A National Database Study.

Cureus 2020 Feb 9;12(2):e6924. Epub 2020 Feb 9.

Dermatology, Liverpool Hospital, Sydney, AUS.

Introduction While prior studies have addressed the gender-specific survival of malignant melanoma, such investigation is lacking for melanoma in situ (MIS) and for the sun-exposed head and neck areas. Understanding the role of patient characteristics on disease prognosis is essential in determining optimal patient treatment and follow-up. We conducted a retrospective cohort study of patients diagnosed with MIS of the head and neck to assess the association of gender with long-term survival. Read More

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http://dx.doi.org/10.7759/cureus.6924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064266PMC
February 2020

Correlative Monitoring of Immune Activation and Tissue Damage in Malignant Melanoma-An Algorithm for Identification of Tolerance Breakage During Immune Checkpoint Inhibitor Therapy of Cancer.

Int J Mol Sci 2020 Mar 16;21(6). Epub 2020 Mar 16.

Department of Dermatology, Euregio Skin Cancer Center, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.

We describe an innovative approach for identification of tolerance breakage during immune checkpoint inhibitor therapy in malignant melanoma. Checkpoint inhibitor therapy enhances the immunologic clearance of cancer by suppressing pathways which induce immune suppression and tolerance. We posit that by analyzing temporal correlations of key markers of immune activation and tissue damage it would be possible to detect the onset of anticancer immune reaction as well as of immunologic adverse effects which might become crucial for optimization as well as safety of immune checkpoint inhibitor treatment. Read More

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http://dx.doi.org/10.3390/ijms21062020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139313PMC

Report on fluorescence lifetime imaging using multiphoton laser scanning microscopy targeting sentinel lymph node diagnostics.

J Biomed Opt 2020 Mar;25(7):1-8

University of Gothenburg, Biomedical Photonics Group, Department of Chemistry and Molecular Biology,, Sweden.

Significance: Sentinel lymph node (SLN) biopsy is an important method for metastasis staging in, e.g., patients with malignant melanoma. Read More

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http://dx.doi.org/10.1117/1.JBO.25.7.071204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070082PMC

BRAF V600E mutational load as a prognosis biomarker in malignant melanoma.

PLoS One 2020 13;15(3):e0230136. Epub 2020 Mar 13.

Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, UPV/EHU, Leioa, Spain.

Analyzing the mutational load of driver mutations in melanoma could provide valuable information regarding its progression. We aimed at analyzing the heterogeneity of mutational load of BRAF V600E in biopsies of melanoma patients of different stages, and investigating its potential as a prognosis factor. Mutational load of BRAF V600E was analyzed by digital PCR in 78 biopsies of melanoma patients of different stages and 10 nevi. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230136PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069620PMC

The heel amelanotic melanoma, a rare subtype of skin cancer misdiagnosed as foot ulcer: A case report.

Int Wound J 2020 Jun 11;17(3):819-822. Epub 2020 Mar 11.

Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Amelanotic melanoma (AM) of the heel is a very rare subtype of malignant melanoma in which the tumour cells, unlike other types of melanoma, are characterised by little or no melanin pigmentation. AM resembles many benign dermatological complications that often lead to late diagnosis of lesions, poor prognosis, and occasionally misdiagnosis at an early stage of the disease. We report a case of a 73-year-old man with a heel ulcer who was admitted to Al-Zahra Hospital (Isfahan, Iran). Read More

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http://dx.doi.org/10.1111/iwj.13338DOI Listing
June 2020
2.023 Impact Factor

Oxidative Phosphorylation Promotes Primary Melanoma Invasion.

Am J Pathol 2020 May 3;190(5):1108-1117. Epub 2020 Mar 3.

Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York. Electronic address:

Dermal invasion is a hallmark of malignant melanoma. Although the molecular alterations that drive the progression of primary melanoma to metastatic disease have been studied extensively, the early progression of noninvasive primary melanoma to an invasive state is poorly understood. To elucidate the mechanisms underlying the transition from radial to vertical growth, the first step in melanoma invasion, we developed a zebrafish melanoma model in which constitutive activation of ribosomal protein S6 kinase A1 drives tumor invasion. Read More

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http://dx.doi.org/10.1016/j.ajpath.2020.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237828PMC

Utility of histone H3K27me3 and H4K20me as diagnostic indicators of melanoma.

Melanoma Res 2020 04;30(2):159-165

Department of Biochemistry and Molecular Biology.

Histone posttranslational modifications (PTMs) have been shown to be dysregulated in multiple cancers including melanoma, and as they are abundant and easily detectable, they make ideal biomarkers. The aim of this study was to identify histone PTMs that could be potential biomarkers for melanoma diagnosis. Previously, we utilized mass spectrometry to identify histone PTMs that were dysregulated in matched melanoma cell lines and found two modifications, H3 lysine 27 trimethylation (histone H3K27me3) and H4 lysine 20 monomethylation (histone H4K20me), that were differentially expressed in the more aggressive compared to the less aggressive cell line. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080300PMC

Long non-coding RNA FENDRR inhibits migration and invasion of cutaneous malignant melanoma cells.

Biosci Rep 2020 Mar;40(3)

Department of Dermatology, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, China.

The present study aimed to investigate the effects of lncRNA FENDRR on the migration and invasion of malignant melanoma (MM) cells. The expression levels of FENDRR in MM tissues and MM cell lines were detected using qRT-PCR, followed by construction of FENDRR-knocked down and overexpressed stable cells. Then the effects of FENDRR on cell proliferation, migration and invasion were detected using MTT assay and Transwell assay. Read More

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http://dx.doi.org/10.1042/BSR20191194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080643PMC

Survival in 31 670 patients with thin melanomas: a Swedish population-based study.

Br J Dermatol 2020 Mar 4. Epub 2020 Mar 4.

Departments of Medical and Health Sciences, Linköping University, Linköping, Sweden.

Background: The incidence of cutaneous malignant melanoma (CMM) continues to increase in most countries worldwide and the majority are diagnosed with thin tumours (≤ 1 mm).

Objectives: The aim of the present study was to investigate the melanoma-specific survival (MSS) as well as conditional MSS (CMSS) in patients with thin CMM in Sweden.

Patients And Methods: Clinical and histological parameters were obtained from the Swedish Melanoma Registry for patients diagnosed with thin CMM between 1990 and 2017. Read More

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http://dx.doi.org/10.1111/bjd.19015DOI Listing

Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin.

J Cell Mol Med 2020 Apr 4;24(7):4324-4340. Epub 2020 Mar 4.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Malignant melanoma is one of the most invasive tumours. However, effective therapeutic strategies are limited, and overall survival rates remain low. By utilizing transcriptomic profiling, tissue array and molecular biology, we revealed that two key ubiquitin-specific proteases (USPs), ubiquitin-specific peptidase10 (USP10) and ubiquitin-specific peptidase10 (USP13), were significantly elevated in melanoma at the mRNA and protein levels. Read More

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http://dx.doi.org/10.1111/jcmm.15093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171391PMC

Primary malignant melanoma of uterine cervix.

G Ital Dermatol Venereol 2020 Mar 4. Epub 2020 Mar 4.

Dermatology and Venereology Department, Dermatology Clinic, Maggiore Hospital of Trieste, Trieste, Italy.

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http://dx.doi.org/10.23736/S0392-0488.19.06512-XDOI Listing

Beta3-Tubulin is Critical for Microtubule Dynamics, Cell Cycle Regulation, and Spontaneous Release of Microvesicles in Human Malignant Melanoma Cells (A375).

Int J Mol Sci 2020 Feb 28;21(5). Epub 2020 Feb 28.

Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB T2T 5C7, Canada.

Microtubules (MTs), microfilaments, and intermediate filaments, the main constituents of the cytoskeleton, undergo continuous structural changes (metamorphosis), which are central to cellular growth, division, and release of microvesicles (MVs). Altered MTs dynamics, uncontrolled proliferation, and increased production of MVs are hallmarks of carcinogenesis. Class III beta-tubulin (β3-tubulin), one of seven β-tubulin isotypes, is a primary component of MT, which correlates with enhanced neoplastic cell survival, metastasis and resistance to chemotherapy. Read More

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http://dx.doi.org/10.3390/ijms21051656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084453PMC
February 2020

The Importance of Dermoscopy in Early Recognition of Melanoma in Situ.

Curr Health Sci J 2019 Oct-Dec;45(4):366-371. Epub 2019 Dec 30.

Department of Internal Medicine, Medical Center Dr. Ianosi, Craiova, Romania.

Early recognition of melanoma in situ (MIS) is an ongoing challenge in dermatology. It rarely arises 'de novo', most frequently resulting due to the transformation of an atypical nevus. The diagnostic criteria for MIS are diverse dermoscopy being the most used and it has a sensitivity of 83% and a specificity of 69% in detecting melanomas. Read More

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http://dx.doi.org/10.12865/CHSJ.45.04.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014979PMC
December 2019

Heavy Water Affects Vital Parameters of Human Melanoma Cells in vitro.

Cancer Manag Res 2020 17;12:1199-1209. Epub 2020 Feb 17.

Department of Dermatology, Venereology and Allergy, Johann Wolfgang Goethe University, Frankfurt/Main, Germany.

Purpose: Although regular water is composed of two hydrogens and one oxygen, referred to as HO, a small amount of water on this planet contains alternative forms of elements with different molecular weights because of the addition of neutrons. The present study was dedicated to studying the effect of heavy water (DO), in which the two hydrogens become substituted by deuterium, on the cell physiology of different human cells with particular focus on malignant melanoma cells.

Methods: Cells were cultured in regular medium in which the content of HO was gradually substituted by DO or deuterium-depleted water (DDW). Read More

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http://dx.doi.org/10.2147/CMAR.S230985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034964PMC
February 2020

Plantamajoside represses the growth and metastasis of malignant melanoma.

Exp Ther Med 2020 Mar 10;19(3):2296-2302. Epub 2020 Jan 10.

College of Medical Technology, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu 224000, P.R. China.

Plantamajoside (PMS) has been shown to have anticancer effects and is the main compound of . The aim of the present study was to investigate the effects of PMS on malignant melanoma and its molecular mechanisms. The malignant melanoma cell line A2058 was treated with different concentrations of PMS (0, 20, 80 and 160 µg/ml) for 24, 48 or 72 h, followed by cell viability detection using the Cell Counting Kit-8 assay. Read More

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http://dx.doi.org/10.3892/etm.2020.8442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027332PMC

Long non-coding RNA NEAT1 promotes tumor development and metastasis through targeting miR-224-5p in malignant melanoma.

Authors:
J-X Zou T-W Ge

Eur Rev Med Pharmacol Sci 2020 Feb;24(3):1302-1308

Department of Dermatology, The People's Hospital of Danyang, Danyang, China.

Objective: Melanoma is one of the most ordinary malignant tumors. Recent studies have revealed that long noncoding RNAs (lncRNAs) play an important role in the progression of tumorigenesis. This work aims to identify how lncRNA NEAT1 functions in the progression of melanoma. Read More

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http://dx.doi.org/10.26355/eurrev_202002_20187DOI Listing
February 2020

Repurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications.

J Exp Clin Cancer Res 2020 Feb 21;39(1):38. Epub 2020 Feb 21.

Department of Molecular Medicine II, Medical Faculty, Heinrich-Heine-University, Universitätsstraße 1, 40225, Düsseldorf, Germany.

Background: New therapies are urgently needed in melanoma particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors.

Methods: Drug screening, IC50 determinations as well as synergy assays were detected by the MTT assay. Apoptosis using Annexin V and 7AAD staining was assessed using flow cytometry. Read More

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http://dx.doi.org/10.1186/s13046-020-1539-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035645PMC
February 2020

Video Education to Promote Skin Cancer Awareness and Identification in Spanish-speaking Patients.

J Clin Aesthet Dermatol 2020 Jan 1;13(1):41-43. Epub 2020 Jan 1.

Dr. Garcia is with the Department of Internal Medicine at Loma Linda University in Loma Linda, California.

We sought to evaluate the efficacy of a Spanish-language educational video in teaching primary Spanish speaking patients to recognize benign and malignant lesions and to increase their awareness about skin cancer. Thirty-seven subjects were enrolled in study. An instructional video was developed to increase knowledge of benign and malignant lesions, skin cancer awareness, and prevention among Spanish-speaking patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028375PMC
January 2020

Rethinking the Journal Impact Factor and Publishing in the Digital Age.

J Clin Aesthet Dermatol 2020 Jan 1;13(1):12-17. Epub 2020 Jan 1.

Drs. Nestor, Fischer, Arnold, and Berman are with the Center for Clinical and Cosmetic Research in Aventura, Florida.

Clinical and experimental literature search has changed significantly over the past few decades, and with it, the way in which we value information. Today, our need for immediate access to relevant and specific literature, regardless of specialty, has led to a growing demand for open access to publications. The Journal Impact Factor (JIF) has been a long-time standard for representing the quality or "prestige" of a journal, but it appears to be losing its relevance. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028381PMC
January 2020

Prognostic factors in 161 patients with mucosal melanoma: a study of German Central Malignant Melanoma Registry.

J Eur Acad Dermatol Venereol 2020 Feb 20. Epub 2020 Feb 20.

Center for Dermatooncology, Department of Dermatology, Eberhard Karls University of Tuebingen, Tuebingen, Germany.

Background: Mucosal melanoma is a rare malignancy which represents approximately 1% of all melanomas. It is shown that mucosal melanomas have a different biology and less favourable prognosis than its cutaneous counterpart.

Objectives: Predictive and prognostic factors of survival for mucosal melanoma have not yet been elucidated. Read More

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http://dx.doi.org/10.1111/jdv.16306DOI Listing
February 2020

Giant Congenital Melanocytic Nevi Successfully Treated with Combined Laser Therapy.

Indian Dermatol Online J 2020 Jan-Feb;11(1):79-82. Epub 2020 Jan 13.

Department of Dermatology. Sakhiya Skin Clinic PVT LTD, Surat, Gujarat, India.

Congenital melanocytic nevi are benign proliferations of cutaneous melanocytes that arise as a result of abnormal growth, development, or migration of melanoblasts. Clinically, the giant congenital nevus is greater than 20 cm in size, pigmented and often hairy. The risk of malignant melanoma for the giant nevi is almost 6%. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_107_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001409PMC
January 2020

Clinical Outcomes of Immune Checkpoint Blocker Therapy for Malignant Melanoma in Korean Patients: Potential Clinical Implications for a Combination Strategy Involving Radiotherapy.

Cancer Res Treat 2020 Feb 13. Epub 2020 Feb 13.

Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Purpose: We investigated the clinical efficacy of immune checkpoint blocker (ICB) therapy for metastatic or advanced melanoma in Korean patients. As well, we assessed whether the effects of ICBs can be enhanced by combination therapy with palliative radiotherapy (RT).

Materials And Methods: We retrospectively reviewed the records of 127 patients with metastatic melanoma who received ICB with or without palliative RT between 2014 and 2018. Read More

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http://dx.doi.org/10.4143/crt.2019.598DOI Listing
February 2020
2.975 Impact Factor

Intratumoral injection of hemagglutinating virus of Japan-envelope vector yielded an antitumor effect for advanced melanoma: a phase I/IIa clinical study.

Cancer Immunol Immunother 2020 Jun 11;69(6):1131-1140. Epub 2020 Feb 11.

Department of Dermatology, Course of Integrated Medicine Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita-shi, Osaka, 565-0871, Japan.

Hemagglutinating virus of Japan (HVJ; Sendai virus) is an RNA virus that has cell fusion activity. HVJ-envelope (HVJ-E) is a UV-irradiated HVJ particle that loses viral replication and protein synthesis activity but retains cell fusion activity. We recently reported that HVJ-E has antitumor effects on several types of tumors. Read More

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http://dx.doi.org/10.1007/s00262-020-02509-8DOI Listing

Vitiligo-like lesions located over In-transit metastases of malignant melanoma as a clinical marker of complete response to pembrolizumab.

Dermatol Online J 2019 Dec 15;25(12). Epub 2019 Dec 15.

Dermatology Department, Hospital de Barbastro, Huesca.

Anti-programmed cell death (PD)-1 therapies in metastatic tumors have a high incidence of immune adverse events, including cutaneous manifestations such as vitiligo-like lesions. This side effect is associated with increased survival and it is a clinical marker of response to treatment. This case report is a graphic representation of the appearance of vitiligo-like lesions over in-transit metastases of malignant melanoma linked to a complete response to treatment with pembrolizumab. Read More

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December 2019

A novel surgical margin (1 cm) might be from benefit for patients with dysplastic nevi, thin melanomas, and melanoma in situ: Analysis based on clinical cases.

Dermatol Ther 2020 Mar 17;33(2):e13261. Epub 2020 Feb 17.

Department of Dermatology and Venereology, University of Rome "G. Marconi", Rome, Italy.

Malignant melanoma is an oncologic disease, whose current management among others includes surgical and immunological therapy. According to the current recommendations of the American Joint Committee on Cancer, the surgical excision of the primary tumor should be performed in two operative sessions, which has several consequences. The following paper will present and discuss six cases of pigmented lesions and the advantages of the one-step melanoma surgery in their management. Read More

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http://dx.doi.org/10.1111/dth.13261DOI Listing
March 2020
1.478 Impact Factor