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Oncol Lett 2021 Jul 27;22(1):495. Epub 2021 Apr 27.

Department of Dermatology, The Affiliated Changzhou No. 2 People's Hospital with Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China.

Double homeobox A pseudogene 8 (DUXAP8) has been reported to regulate the growth of several types of cancers, such as breast cancer and ovarian cancer. However, its role in melanoma remains unclear. In the present study, the mechanism through which DUXAP8 regulates melanoma progression was explored. Read More

J Dermatol 2021 May 7. Epub 2021 May 7.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

J Dermatol 2021 May 7. Epub 2021 May 7.

Division of Dermatology, Niigata Cancer Center Hospital, Niigata, Japan.

Based on the results of international multicenter randomized trials, completion lymph node dissection for patients with sentinel lymph node-positive melanoma is no longer routinely recommended. However, clinicians should take into consideration racial and medical resource differences when applying this evidence to clinical practice in Japan. To evaluate the clinical validity of the observation policy of omitting completion lymph node dissection, we retrospectively surveyed patients with sentinel lymph node-positive melanoma between 2002 and 2020 at Niigata Cancer Center Hospital. Read More

Dermatol Pract Concept 2021 Mar 12;11(2):e2021033. Epub 2021 Apr 12.

Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.

Background: Teledermoscopy can be used to triage referrals of suspected skin cancers, thereby reducing waiting time and number of face-to-face consultations with a dermatologist. However, the success of the implementation of this technology in part relies on the acceptance of the providers.

Objectives: This study assessed the attitudes towards teledermoscopy of referring general practitioners and consultant dermatologists. Read More

J Cell Mol Med 2021 May 3. Epub 2021 May 3.

Department of Endocrinology, Translational Research Key Laboratory for Diabetes, Xinqiao Hospital, Army Medical University, Chongqing, China.

Oxidative stress critically influences carcinogenesis and the progression of melanoma, and aggressive malignant melanoma activity is due to its high metastatic ability. Some findings in several cancer cell lines have indicated that mGPDH, a component of the mitochondrial respiratory chain, also modulates oxidative stress. However, the role of mGPDH in melanoma remains elusive. Read More

Int J Womens Dermatol 2021 Mar 2;7(2):127-134. Epub 2021 Feb 2.

Callender Dermatology and Cosmetic Center, Glenn Dale, MD, United States.

Malignant melanoma and nonmelanoma skin cancers (NMSC), which include basal cell carcinoma and squamous cell carcinoma, account for 40% of all neoplasms in white patients, making these cancers the most common malignancy in the United States. Given the large number of NMSC cases in white patients, there is a correspondingly large body of literature addressing various aspects of epidemiology, pathogenesis, and treatment. The incidence of both malignant melanoma and NMSC is well established and remains significantly lower in patients with skin of color (SoC) when compared with white patients. Read More

Front Oncol 2021 15;11:637185. Epub 2021 Apr 15.

Department of Neurology, Division of Clinical Neurooncology, University Hospital Essen, Essen, Germany.

Immune checkpoint inhibitors (ICIs) have considerably expanded the effective treatment options for malignant melanoma. ICIs revert tumor-associated immunosuppression and potentiate T-cell mediated tumor clearance. Immune-related neurologic adverse events (irNAEs) manifest in the central (CNS) or peripheral nervous system (PNS) and most frequently present as encephalitis or myasthenia gravis respectively. Read More

Clin Case Rep 2021 Apr 7;9(4):2200-2204. Epub 2021 Mar 7.

Department of Medical Oncology IRCCS Azienda Ospedaliero-Universitaria Sant'Orsola -Malpighi Hospital Bologna Italy.

We report the case of a young woman who developed metastatic melanoma in the inguinal nodal region, which acquired chondrosarcomatous differentiation and preserved the BRAF mutation found in the primary tumor. The patient was treated with a BRAF/MEK inhibitor combination therapy (dabrafenib/trametinib), which was demonstrated to be effective and well-tolerated. Read More

J Pers Med 2021 Apr 12;11(4). Epub 2021 Apr 12.

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.

Primary diffuse leptomeningeal melanomatosis (PDLMM) is an extremely rare and aggressive cancer type for which best treatment strategies remain to be elucidated. Herein, we present current and prospective diagnostic strategies and treatment management of PDLMM. Against the background of an extensive literature review of published PDLMM cases and currently employed therapeutic strategies, we present an illustrative case of a pediatric patient suffering from PDLMM. Read More

Int J Mol Sci 2021 Apr 4;22(7). Epub 2021 Apr 4.

Emil-Fischer-Center, Institute of Biochemistry, University of Erlangen-Nuernberg, 91054 Erlangen, Germany.

Cold atmospheric plasma (CAP) is partially ionized gas near room temperature with previously reported antitumor effects. Despite extensive research and growing interest in this technology, active components and molecular mechanisms of CAP are not fully understood to date. We used Raman spectroscopy and colorimetric assays to determine elevated nitrite and nitrate levels after treatment with a MiniFlatPlaster CAP device. Read More

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

Department of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, D-66421 Homburg, Germany.

oncogene located at chromosomal region 3q26 encodes for a transmembrane protein of the endoplasmic reticulum (ER) and is expressed at high levels in numerous human malignancies. overexpression has been associated with worse prognosis and high risk for lymphatic and distant metastases in head and neck cancer, cervical cancer, hepatocellular cancer, and lung cancer. However, its role in the development and tumor biology of melanocytic lesions has not been investigated so far. Read More

Ann Dermatol 2021 Feb 30;33(1):18-25. Epub 2020 Dec 30.

Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Background: Acral melanoma occurs on glabrous skin or the nail apparatus and is distinct from ultraviolet-related melanoma due to differing genetic alteration patterns. Although the pathogenesis of acral melanoma is not well understood, mechanical stress is thought to induce acral melanoma. The incidence of gene mutation and promoter methylation has been reported in tumors from acral melanoma; however, an association between genetic/epigenetic alterations and mechanical stress in acral melanoma remains unclear. Read More

Ann Dermatol 2020 Dec 11;32(6):460-465. Epub 2020 Nov 11.

Department of Dermatology, Pusan National University Hospital, Busan, Korea.

Background: Fungal melanonychia (FM) is a rare nail disorder that presents as dark pigmentation in the nail plate because of fungal nail infection. The diagnosis of FM is occasionally confusing because its appearance is similar to melanonychia due to other causes including malignant melanoma. Dermoscopy could help increase the accuracy of diagnosing the cause of pigmented nail lesions. Read More

Ann Dermatol 2020 Jun 24;32(3):233-236. Epub 2020 Apr 24.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Spark's nevus is a compound word composed of Spitz nevus and Clark's nevus. It is one of the combined melanocytic nevi which is more common in female and usually presents as a sharp circumscribed hyperpigmented macule on the lower extremities. On histopathologic findings, both cytologic features of Spitz nevus characterized as large spindle or epithelioid melanocytes containing large nuclei with abundant cytoplasm, and architecture of Clark's nevus characterized as elongation of rete ridges, bridging of the nests, concentric and lamellar fibrosis can be seen. Read More

BMJ Case Rep 2021 Apr 28;14(4). Epub 2021 Apr 28.

General Surgery, BYL Nair Charitable Hospital, Mumbai, Maharashtra, India

Malignant melanoma of the anal canal is a rare and aggressive tumour associated with significant mortality. Early diagnosis and early curative surgical resection have shown to offer a survival advantage. We present a case of 53-year-old woman, who was accidentally diagnosed to have a localised lesion of malignant melanoma of the anal canal on histopathology report of the specimen of haemorrhoidectomy done for thrombosed external haemorrhoids. Read More

J Dermatol 2021 Apr 27. Epub 2021 Apr 27.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Dermoscopic images of pigmented lesions have distinct features on the sole where skin ridges and furrows exist. Pigmentation of benign nevus usually locates on the skin furrow, while the malignant melanoma is pigmented on the skin ridge. Correspondence between dermoscopy and pathology in the pigmented lesions on soles have been studied based on conventional vertical pathological images. Read More

Mol Med Rep 2021 Jul 28;24(1). Epub 2021 Apr 28.

Department of Dermatology, Jining First People's Hospital, Jining, Shandong 272000, P.R. China.

Following the publication of the above paper, a concerned reader drew to the Editor's attention that several figures (Figs. 3‑8 inclusive) contained apparent anomalies, including repeated patternings of data within the same figure panels. After having conducted an independent investigation in the Editorial Office, the Editor of has determined that the above paper should be retracted from the Journal on account of a lack of confidence concerning the originality and the authenticity of the data. Read More

J Multidiscip Healthc 2021 21;14:877-885. Epub 2021 Apr 21.

Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan.

Background: Incidence of skin cancer is one of the global burdens of malignancies that increase each year, with melanoma being the deadliest one. Imaging-based automated skin cancer detection still remains challenging owing to variability in the skin lesions and limited standard dataset availability. Recent research indicates the potential of deep convolutional neural networks (CNN) in predicting outcomes from simple as well as highly complicated images. Read More

J Dtsch Dermatol Ges 2021 Apr 22. Epub 2021 Apr 22.

Skin Cancer Center, Department of Dermatology, Allergology and Phlebology, Klinikum Bremerhaven.

Background: Patients with stage IIC malignant melanoma are recommended to undergo cross-sectional imaging for initial staging. PET/CT is superior to other methods regarding its diagnostic accuracy of the tumor spread in stage III. So far there is no meaningful data on the nationwide availability, usage and cost recovery of this imaging technique. Read More

World J Clin Cases 2021 Apr;9(10):2352-2356

Department of Medical Laboratory, Southern Medical University, Guangzhou 510515, Guangdong Province, China.

Background: Primary intramedullary melanoma is a very rare tumor, most frequently occurring in the cervical and thoracic spinal cord.

Case Summary: We present a rare case in which the primary intramedullary melanoma was located in the lumbar spine. A 56-year-old man complained of progressive intermittent pain in the lumbar area. Read More

BMJ Case Rep 2021 Apr 12;14(4). Epub 2021 Apr 12.

Otorhinolaryngology, AZ Damiaan Oostende, Oostende, Belgium.

Mod Rheumatol Case Rep 2021 Apr 6:1-6. Epub 2021 Apr 6.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Immune checkpoint inhibitors (ICIs) such as nivolumab and ipilimumab are emerging agents for the treatment of cancers including melanoma. ICIs are known to cause immune-related adverse events (irAEs), including the development of enterocolitis, dermatitis, and nephritis. However, ICI-induced pancreatitis has seldom been reported, and its pathophysiology and clinical importance remain largely unknown. Read More

Pathogens 2021 Mar 10;10(3). Epub 2021 Mar 10.

Department of Biomedical Sciences, Duluth Campus, Medical School, University of Minnesota, Duluth, MN 55812, USA.

, , and are bacteria known to cause verruga peruana or bacillary angiomatosis, vascular endothelial growth factor (VEGF)-dependent cutaneous lesions in humans. Given the bacteria's association with the dermal niche and clinical suspicion of occult infection by a dermatologist, we determined if patients with melanoma had evidence of spp. infection. Read More

Cancers (Basel) 2021 Mar 8;13(5). Epub 2021 Mar 8.

Department of Dermatology Integrated Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

Cutaneous squamous cell carcinoma (cSCC) is the second most prevalent skin cancer globally. Because most cSCC cases are manageable by local excision/radiotherapy and hardly become life-threatening, they are often excluded from cancer registries in most countries. Compared with cutaneous melanoma that originates from the melanin-producing, neural crest-derived epidermal resident, keratinocyte (KC)-derived cancers are influenced by the immune system with regards to their pathogenetic behaviour. Read More

Biotechnol Appl Biochem 2021 Apr 1. Epub 2021 Apr 1.

Department of Dermatology, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, China.

Green tea polyphenols (GTPs) are regarded as anticancer substance and have been revealed to play significant roles in the development of malignant melanoma. However, the mechanisms by which GTPs perform anti-carcinogenic activity are not well elucidated. Cellular function assays revealed that GTPs inhibited melanoma cell proliferation, migration, invasion, EMT, and promoted apoptosis in vitro. Read More

Cancer 2021 Mar 31. Epub 2021 Mar 31.

Université de Paris, AP-HP Dermatology, INSERM U976, Saint Louis Hospital, Paris, France.

Eur J Cancer 2021 May 25;148:340-347. Epub 2021 Mar 25.

Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

Accurate classification of melanocytic proliferations has important implications for prognostic prediction, treatment and follow-up. Although most melanocytic proliferations can be accurately classified using clinical and pathological criteria, classification (specifically distinction between nevus and melanoma) can be challenging in a subset of cases, including those with spitzoid morphology. Genetic studies have shown that mutation profiles differ between primary melanoma subtypes and Spitz nevi. Read More

J Cancer Res Clin Oncol 2021 Mar 26. Epub 2021 Mar 26.

Department of Dermatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Purpose: To enhance the antitumor effects of anti-programmed death-1 (PD-1) antibodies, it is important to reverse cancer-induced immunosuppression. We previously reported that a localized renin-angiotensin system in the tumor microenvironment inhibited tumor immunity via macrophages. In this study, we analyzed the underlying mechanism through which fibroblasts express tumor immunity influenced by the angiotensin receptor. Read More

Indian J Dermatol Venereol Leprol 2021 Mar-Apr;87(2):270-273

Department of Dermatology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.

Indian J Dermatol Venereol Leprol 2021 Mar-Apr;87(2):293-297

Department of Dermatology, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu, South Korea.