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    1 OF 2254

    Cutaneous Complications Related to Tattoos: 31 Cases from Finland.
    Dermatology 2017 Apr 26. Epub 2017 Apr 26.
    Department of Dermatology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
    Background: Cutaneous complications related to permanent tattoos affect 2-30% of those patients who have tattooed their skin. Little is known about the cases of tattoo complications in Finland.

    Objective: The aim of this study was to conduct a retrospective review of a series of Finnish patients with cutaneous tattoo reactions. Read More

    Pro-tumor activities of macrohpages in the progression of melanoma.
    Hum Vaccin Immunother 2017 Apr 25. Epub 2017 Apr 25.
    d Research Center of Basic Medical Sciences, Tianjin Medical University , Tianjin , China.
    Macrophages are located in essentially all tissues due to their "janitor" function. Macrophages can exert either anti- or pro-tumor activities depending upon the specific tumor microenvironment they inhabit. Substantial evidence indicates that macrophages, owing to their plasticity, can be reeducated to adopt a protumoral phenotype within a tumor microenvironment through the help of growth factors in the microenvironment and intercellular interactions. Read More

    Clinical Significance of Circulating Serum Cellular Heat Shock Protein 90 (HSP90) Level in Patients with Cutaneous Malignant Melanoma
    Asian Pac J Cancer Prev 2017 03 1;18(3):599-601. Epub 2017 Mar 1.
    Institute of Oncology, University of Istanbul, Istanbul, Turkey. Email:
    Background: Cellular heat shock proteins (HSPs) play significant roles in sustaining normal cellular conditions. The stimulated expressions of HSPs result in cellular stabilization at times of stress, such as cancer. The objective of this study was to determine the clinical significance of the serum levels of HSP90 in melanoma patients. Read More

    Modulation of MMP-2 and -9 secretion by cytokines, inducers and inhibitors in human melanoma A-2058 cells.
    Oncol Rep 2017 Apr 24. Epub 2017 Apr 24.
    Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050, USA.
    Melanoma, an extremely aggressive cancer, causes the most skin cancer-related deaths, due to metastasis to other areas of the body, such as lymph nodes, lungs, liver, brain or bone. It is characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions that degrade the extracellular matrix and basement membrane, allowing cancer cells to spread to distal organs. Various cytokines, mitogens, growth factors, inducers and inhibitors control MMP activities. Read More

    Expression levels of microRNA‑455 and its potential functions by targeting IGF‑1R in melanoma.
    Mol Med Rep 2017 Apr 12. Epub 2017 Apr 12.
    Department of Dermatology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.
    Melanoma has the highest fatality and malignancy of all skin cancers. In cancer, microRNAs (miRNAs) act as tumor suppressors or oncogenes, and inactivation of oncogenic miRNAs or restoration of tumor suppressor miRNAs has potential for cancer treatment. In the present study, miR‑455 expression levels were examined in melanoma tissues and cell lines, and miR‑455 was significantly downregulated in melanoma compared with matched normal tissues or normal epidermal melanocytes. Read More

    MicroRNA expression in esophageal squamous cell carcinoma: Novel diagnostic and prognostic biomarkers.
    Mol Med Rep 2017 Apr 13. Epub 2017 Apr 13.
    Department of Thoracic Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
    The aim of the present study was to identify more effective molecular diagnostic biomarkers for esophageal squamous cell carcinoma (ESCC). The non‑coding RNA profile GSE43732, generated from 238 paired frozen tissues from 119 patients, was analyzed. Raw data were preprocessed and the differentially expressed miRNAs were screened by limma package with log2 fold change >2. Read More

    Motor polyradiculopathy during pembrolizumab treatment of metastatic melanoma.
    Muscle Nerve 2017 Apr 25. Epub 2017 Apr 25.
    Department of Neurology, Hospital Clínic, University of Barcelona, Barcelona, Spain.
    Introduction: Pembrolizumab, a monoclonal antibody directed against the immune checkpoint PD-1 (programmed cell death-1 receptor), has improved survival in patients with advanced melanoma. Neuromuscular immune-mediated side effects have been rarely reported.

    Methods: We describe a 44-year-old man with metastatic melanoma who presented with progressive muscle weakness after 23 doses of pembrolizumab. Read More

    Interdigital melanoma simultaneously affecting two neighboring interdigital spaces : First description in the medical literature.
    Wien Med Wochenschr 2017 Apr 24. Epub 2017 Apr 24.
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
    Background: Interdigital melanoma, as a subtype of acral lentiginous melanoma, is relatively uncommon in the Caucasian population. It frequently goes unrecognized for a prolonged period of time prior to diagnosis, due to its asymptomatic nature and variable clinical appearance.

    Methods: We report the case of a 67-year-old Caucasian woman who presented with interdigital malignant melanoma affecting two neighboring interdigital spaces. Read More

    Comparative study of p16 protein expression in squamous cell carcinomas from patients with epidermodysplasia verruciformis and patients without the disease.
    Arch Dermatol Res 2017 Apr 24. Epub 2017 Apr 24.
    Department of Dermatology, University of São Paulo Medical School, Avenida Dr. Arnaldo, 455, São Paulo, SP, 01246-903, Brazil.
    Epidermodysplasia verruciformis (EV) is a rare genodermatosis associated with susceptibility to beta-human papilloma virus (HPV) infection. EV patients develop disseminated warts and non-melanoma skin cancer, mainly squamous cell carcinomas (SCC) that are locally aggressive. EV pathogenesis is not yet fully understood, but alterations in the p16 gene play a role in the pathogenesis of neoplasms caused by high-risk genital HPV. Read More

    Correlation Between Expression of the Cancer/Testis Antigen KK-LC-1 and Helicobacter pylori Infection in Gastric Cancer.
    In Vivo 2017 May-Jun;31(3):403-407
    Division of Biomedical Research, Kitasato University Medical Center, Kitamoto, Japan.
    Background/aim: Our previous study indicated that Kita-kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) expressed in 82% of gastric cancer cases. Here, we investigated the relationship between KK-LC-1 expression and Helicobacter pylori infection in Japanese patients with gastric cancer.

    Patients And Methods: We examined CTA expression in 25 surgical gastric cancer specimens and anti-H. Read More

    A tenebrous tale: malignant melanoma of the oesophagus.
    BMJ Case Rep 2017 Apr 24;2017. Epub 2017 Apr 24.
    University of Dublin Trinity College, Dublin, Ireland.
    A 57-year-old man presented with a 4-month history of worsening symptoms of oesophageal obstruction. The physical examination was unremarkable. An oesophagogastroduodenoscopy revealed an exophytic tumour in the distal oesophagus. Read More

    Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome induced by nivolumab.
    Semin Arthritis Rheum 2017 Mar 8. Epub 2017 Mar 8.
    Dermatology Department, INSERM U976, Saint-Louis Hospital, Sorbonne Paris Cité, Université Paris Diderot, Paris, France.
    Introduction: A new articular syndrome described as immunrelated side effect of immunotherapy: PD-1 inhibitors have revolutionized the treatment of advanced melanoma but are responsible for immune-related toxicity. We report a case of remitting seronegative symetrical synovitis with pitting edema (RS3PE) syndrome induced by nivolumab.

    Case Report: A 80 year-old man with stage IV BRAF-wild type and NRAS exon 2-mutated melanoma was treated first line by nivolumab 3mg/kg every 2 weeks. Read More

    Semi-preparative HPLC purification of δ-tocotrienol (δ-T3) from Elaeis guineensis Jacq. and Bixa orellana L. and evaluation of its in vitro anticancer activity in human A375 melanoma cells.
    Nat Prod Res 2017 Apr 24:1-6. Epub 2017 Apr 24.
    b Department of Pharmacological and Biomolecular Sciences , Università degli Studi di Milano , Milano , Italy.
    In this work, we report a rapid and convenient HPLC-UV-DAD method for the isolation of δ-T3 on semi-preparative scale from two different vitamin E rich processed, commercially available products obtained from the fruits of Elaeis guineensis Jacq. (oil palm) and from the seeds of Bixa orellana L. (achiote tree). Read More

    A STING-activating nanovaccine for cancer immunotherapy.
    Nat Nanotechnol 2017 Apr 24. Epub 2017 Apr 24.
    Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
    The generation of tumour-specific T cells is critically important for cancer immunotherapy. A major challenge in achieving a robust T-cell response is the spatiotemporal orchestration of antigen cross-presentation in antigen-presenting cells with innate stimulation. Here, we report a minimalist nanovaccine, comprising a simple physical mixture of an antigen and a synthetic polymeric nanoparticle, PC7A NP, which generates a strong cytotoxic T-cell response with low systemic cytokine expression. Read More

    Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors.
    J Clin Invest 2017 Apr 24. Epub 2017 Apr 24.
    Therapies using T cells that are programmed to express chimeric antigen receptors (CAR T cells) consistently produce positive results in patients with hematologic malignancies. However, CAR T cell treatments are less effective in solid tumors for several reasons. First, lymphocytes do not efficiently target CAR T cells; second, solid tumors create an immunosuppressive microenvironment that inactivates T cell responses; and third, solid cancers are typified by phenotypic diversity and thus include cells that do not express proteins targeted by the engineered receptors, enabling the formation of escape variants that elude CAR T cell targeting. Read More

    Automatic Skin Lesion Segmentation Using Deep Fully Convolutional Networks with Jaccard Distance.
    IEEE Trans Med Imaging 2017 Apr 18. Epub 2017 Apr 18.
    Automatic skin lesion segmentation in dermoscopic images is a challenging task due to the low contrast between lesion and the surrounding skin, the irregular and fuzzy lesion borders, the existence of various artifacts, and various imaging acquisition conditions. In this article, we present a fully automatic method for skin lesion segmentation by leveraging a 19-layer deep convolutional neural networks (CNNs) that is trained end-to- end and does not rely on prior knowledge of the data. We propose a set of strategies to ensure effective and efficient learning with limited training data. Read More

    Management of skin adverse events associated with immune checkpoint inhibitors in patients with melanoma: A nursing perspective.
    J Am Assoc Nurse Pract 2017 Apr 24. Epub 2017 Apr 24.
    Division of Oncodermatology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois.
    Purpose: Immune checkpoint inhibitors are associated with a unique immune-related side effect profile that requires prompt recognition and management. Skin toxicities are the most common, and often earliest occurring, drug-related adverse events (AEs) of any grade observed upon treatment with these agents. The purpose of this review is to provide practical guidance on the identification and treatment of skin AEs associated with the immune checkpoint inhibitors (ipilimumab, nivolumab, and pembrolizumab) from a nursing perspective, and demonstrate hands-on application of the guidance using relevant patient case studies. Read More

    Empirical Modeling of Physiochemical Immune Response of Multilayer Zinc Oxide Nanomaterials under UV Exposure to Melanoma and Foreskin Fibroblasts.
    Sci Rep 2017 Apr 24;7:46603. Epub 2017 Apr 24.
    Institute of Fundamental and Frontier Science, University of Electronic Science and Technology of China, 610054 Chengdu, China.
    Carcinogenesis is a complex molecular process starting with genetic and epigenetic alterations, mutation stimulation, and DNA modification, which leads to proteomic adaptation ending with an uncontrolled proliferation mechanism. The current research focused on the empirical modelling of the physiological response of human melanoma cells (FM55P) and human foreskin fibroblasts cells (AG01518) to the multilayer zinc oxide (ZnO) nanomaterials under UV-A exposure. To validate this experimental scheme, multilayer ZnO nanomaterials were grown on a femtotip silver capillary and conjugated with protoporphyrin IX (PpIX). Read More

    Rational design of non-resistant targeted cancer therapies.
    Sci Rep 2017 Apr 24;7:46632. Epub 2017 Apr 24.
    CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.
    Drug resistance is one of the major problems in targeted cancer therapy. A major cause of resistance is changes in the amino acids that form the drug-target binding site. Despite of the numerous efforts made to individually understand and overcome these mutations, there is a lack of comprehensive analysis of the mutational landscape that can prospectively estimate drug-resistance mutations. Read More

    Topography of Protein Kinase C βII in Benign and Malignant Melanocytic Lesions.
    Int J Surg Pathol 2017 Apr 1:1066896917706026. Epub 2017 Apr 1.
    2 Laboratory of Pathology, Division of Morphology, University of Crete, Heraklion, Greece.
    Background: Protein kinase C βII promotes melanogenesis and affects proliferation of melanocytic cells but is frequently absent or decreased in melanoma cells in vitro.

    Objective: To investigate PKC-βII expression and spatial distribution within a lesion in various benign and malignant melanocytic proliferations.

    Methods: Expression of PKC-βII was semiquantitatively assessed in the various existing compartments (intraepidermal [not nested], junctional [nested], and dermal) of benign (n = 43) and malignant (n = 28) melanocytic lesions by immunohistochemistry. Read More

    Control of immune cell entry through the tumour vasculature: a missing link in optimising melanoma immunotherapy?
    Clin Transl Immunology 2017 Mar 17;6(3):e134. Epub 2017 Mar 17.
    Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.
    Metastatic melanoma remains a fatal disease to many worldwide, even after the breakthrough introduction of targeted therapies such as BRAF inhibitors and immune checkpoint blockade therapies such as CTLA-4 and PD-1 inhibitors. With advances in our understanding of this disease, as well as the increasing data gathered from patient studies, the significance of the host immune response to cancer progression and response to treatment is becoming clear. More specifically, the presence of intratumoral CD8(+) cytotoxic T-cells correlates with better prognosis whereas the accumulation of monocytes/macrophages and neutrophils in the tumour is often associated with worse prognosis. Read More

    Age-specific acceleration in malignant melanoma.
    F1000Res 2017 9;6:27. Epub 2017 Jan 9.
    Department of Ecology and Evolutionary Biology, University of California, Irvine, USA.
    Background: The overall incidence of melanoma has increased steadily for several years. The relative change in incidence at different ages has not been fully described.  Objective: To describe how incidence at different ages has changed over time and to consider what aspects of tumour biology may explain the observed pattern of change in incidence. Read More

    Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging.
    Theranostics 2017 6;7(5):1257-1265. Epub 2017 Mar 6.
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA, 02114, USA.
    Herein we describe fluorescent derivatives of vemurafenib to probe therapeutic BRAF inhibition in live cells and in vivo. The compounds were evaluated and compared by determining target binding, inhibition of mutant BRAF melanoma cell lines and live cell imaging. We show that vemurafenib-BODIPY is a superior imaging drug to visualize the targets of vemurafenib in live cells and in vivo in non-resistant and resistant melanoma tumors. Read More

    Programmed cell death 1 checkpoint inhibitors in the treatment of patients with advanced melanoma.
    Contemp Oncol (Pozn) 2017 22;21(1):1-5. Epub 2017 Mar 22.
    Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, Poznan, Poland.
    The treatment landscape of advanced melanoma has changed significantly following the discovery and marketing authorisation of immune checkpoints inhibitors. Ipilimumab (anti-CTLA-4) was the first one to be approved, and it. demonstrated long-term survival in about 20% of patients. Read More

    Cuprous oxide nanoparticle-inhibited melanoma progress by targeting melanoma stem cells.
    Int J Nanomedicine 2017 5;12:2553-2567. Epub 2017 Apr 5.
    Department of Cell Biology, Second Military Medical University.
    Recent studies have shown that metal and metal oxide have a potential function in antitumor therapy. Our previous studies demonstrated that cuprous oxide nanoparticles (CONPs) not only selectively induce apoptosis of tumor cells in vitro but also inhibit the growth and metastasis of melanoma by targeting mitochondria with little hepatic and renal toxicities in mice. As a further study, our current research revealed that CONPs induced apoptosis of human melanoma stem cells (CD271(+/high) cells) in A375 and WM266-4 melanoma cell lines and could significantly suppress the expression of MITF, SOX10 and CD271 involved in the stemness maintenance and tumorigenesis of melanoma stem cells. Read More

    Lkb1 deletion in murine B lymphocytes promotes cell death and cancer.
    Exp Hematol 2017 Apr 20. Epub 2017 Apr 20.
    Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27599-7295, USA; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27599-7295, USA; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27599-7295, USA.
    LKB1 (aka STK11) is a potent tumor suppressor in solid tumors such as melanoma and lung adenocarcinoma, but inactivation in hematopoietic cells causes cell death, without signs of tumorigenesis. We noted somatic LKB1 deletion or mutation at low frequency in human B cell lymphoma. In order to determine if LKB1 inactivation is a passenger or driver event in lymphoid cancers, we examined the effects of conditional inactivation of Lkb1 in murine lymphocytes. Read More

    Role of modern immunotherapy in gastrointestinal malignancies: a review of current clinical progress.
    J Hematol Oncol 2017 Apr 24;10(1):86. Epub 2017 Apr 24.
    Division of Medical Oncology, Department of Medicine, Markey Cancer Center, University of Kentucky, 800 Rose Street, CC449, Lexington, KY, 40503, USA.
    Gastrointestinal (GI) cancers are a group of highly aggressive malignancies with a huge disease burden worldwide. There is clearly a significant unmet need for new drugs and therapies to further improve the treatment outcomes of GI malignancies. Immunotherapy is a novel treatment strategy that is emerging as an effective and promising treatment option against several types of cancers. Read More

    The use of immunotherapy in the treatment of melanoma.
    J Hematol Oncol 2017 Apr 24;10(1):88. Epub 2017 Apr 24.
    University of Pittsburgh, Pittsburgh, PA, USA.
    Patients with advanced melanoma have a compromised anti-tumor immune response leading to tumor immune tolerance and a tumor microenvironment conducive to disease progression. Immunotherapy that successfully overcomes this tumor-mediated immune suppression has made the greatest impact in the management of this disease over the past few years. This progress through immunotherapy builds upon earlier successes that interferon-α had in the treatment of melanoma in the adjuvant setting, as well as that of high-dose interleukin-2 in advanced melanoma. Read More

    Patient-reported outcomes in cancer survivors: a population-wide cross-sectional study.
    Support Care Cancer 2017 Apr 22. Epub 2017 Apr 22.
    Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia.
    Purpose: There is a lack of robust population-based data regarding the lived experience of cancer survivors. This study assessed the quality of life (QoL) of survivors of breast, colorectal, or prostate cancer, non-Hodgkin lymphoma or melanoma 1, 3 and 5 years post-diagnosis. Associations between various demographic and disease-related factors and QoL were assessed. Read More

    FKBP51s signature in peripheral blood mononuclear cells of melanoma patients as a possible predictive factor for immunotherapy.
    Cancer Immunol Immunother 2017 Apr 22. Epub 2017 Apr 22.
    Department of Molecular Medicine and Medical Biotechnologies, Federico II University, Via Pansini, 5, 80131, Naples, Italy.
    The inhibitory immune checkpoint PD-L1/PD1 promotes the alternative splicing of the FKBP5 gene, resulting in increased expression of its variant 4 in the peripheral blood mononuclear cells of melanoma patients. The variant 4 transcript is translated into the truncated FKBP51s protein. Given the importance of co-inhibitory signalling in tumour immune escape, here we tested the potential for using FKBP51s expression to predict immunotherapy outcomes. Read More

    In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N'-ethylenediamine bidentate ester ligands.
    J Inorg Biochem 2017 Apr 4;172:55-66. Epub 2017 Apr 4.
    Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry, Weinberg 3, D 06120 Halle (Saale), Germany. Electronic address:
    Four novel gold(III) complexes of general formulae [AuCl2{(S,S)-R2eddl}]PF6 (R2eddl=O,O'-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoate, R=n-Pr, n-Bu, n-Pe, i-Bu; 1-4, respectively), were synthesized and characterized by elemental analysis, UV/Vis, IR, and NMR spectroscopy, as well as high resolution mass spectrometry. Density functional theory calculations pointed out that (R,R)-N,N'-configuration diastereoisomers were energetically the most favorable. Duo to high cytotoxic activity complex 3 was chosen for stability study in DMSO, no decomposition occurs within 24h, and for the reaction with ascorbic acid in which was reduced immediately. Read More

    Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence.
    Transl Oncol 2017 Apr 20;10(3):385-395. Epub 2017 Apr 20.
    Affinity Proteomics, SciLifeLab, KTH - Royal Institute of Technology, 171 65 Solna, Sweden. Electronic address:
    Background: Blood-based proteomic profiling may aid and expand our understanding of diseases and their different phenotypes. The aim of the presented study was to profile serum samples from patients with malignant melanoma using affinity proteomic assays to describe proteins in the blood stream that are associated to stage or recurrence of melanoma.

    Material And Methods: Multiplexed protein analysis was conducted using antibody suspension bead arrays. Read More

    Detection of melanoma metastases with PET-Comparison of (18)F-5-FPN with (18)F-FDG.
    Nucl Med Biol 2017 Apr 7;50:33-38. Epub 2017 Apr 7.
    Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
    Introduction: (18)F-5-fluoro-N-(2-(Diethylamino)ethyl)picolinamide ((18)F-5-FPN) is a new positron-emission tomography (PET) radiopharmaceutical with potential for the detection of lymph node (LN) and pulmonary metastatic lesions of melanoma. We compared its performance with that of (18)F-deoxyglucose ((18)F-FDG).

    Methods: Cervical LN and lung melanoma metastasis models were established in C57BL/6 mice. Read More

    Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion.
    Exp Cell Res 2017 Apr 19. Epub 2017 Apr 19.
    National Translational Science Center for Molecular Medicine, Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, PR China. Electronic address:
    Rab22a is a member of the Ras-related small GTPase family, which plays a key role in regulating the recycling of cargo proteins entering cells through clathrin-independent endocytosis (CIE). Rab22a is overexpressed in different cancer types, including liver cancer, malignant melanoma, ovarian cancer and osteosarcoma. However, its oncogenic role remains unknown. Read More

    Phenformin inhibits myeloid-derived suppressor cells and enhances the anti-tumor activity of PD-1 blockade in melanoma.
    J Invest Dermatol 2017 Apr 19. Epub 2017 Apr 19.
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA USA. Electronic address:
    Biguanides, such as the diabetes therapeutics metformin and phenformin, have demonstrated antitumor activity both in vitro and in vivo. However, their potential effects on the tumor microenvironment are largely unknown. Here we report that phenformin selectively inhibits granulocytic myeloid-derived suppressor cells (G-MDSCs) in spleens of tumor bearing mice and ex vivo. Read More

    EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging.
    Int J Pharm 2017 Apr 19. Epub 2017 Apr 19.
    Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università degli Studi di Torino, Via Nizza 52, 10126, Torino, Italy.
    Chemical Exchange Saturation Transfer (CEST) approach is a novel tool within magnetic resonance imaging (MRI) that allows visualization of molecules possessing exchangeable protons with water. Many molecules, employed as excipients for the formulation of finished drug products, are endowed with hydroxyl, amine or amide protons, thus can be exploitable as MRI-CEST contrast agents. Their high safety profiles allow them to be injected at very high doses. Read More

    Quantifying rates of cell migration and cell proliferation in co-culture barrier assays reveals how skin and melanoma cells interact during melanoma spreading and invasion.
    J Theor Biol 2017 Apr 19. Epub 2017 Apr 19.
    Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Kelvin Grove 4059, Australia; School of Mathematical Sciences, QUT, PO Box 2434, Brisbane 4001, Australia. Electronic address:
    Malignant spreading involves the migration of cancer cells amongst other native cell types. For example, in vivo melanoma invasion involves individual melanoma cells migrating through native skin, which is composed of several distinct subpopulations of cells. Here, we aim to quantify how interactions between melanoma and fibroblast cells affect the collective spreading of a heterogeneous population of these cells in vitro. Read More

    Glycoprotein non-metastatic melanoma protein b (Gpnmb) is highly expressed in macrophages of acute injured kidney and promotes M2 macrophages polarization.
    Cell Immunol 2017 Mar 31. Epub 2017 Mar 31.
    Nephrology Department, The Second Xiangya Hospital, Central South University, Key Lab of Kidney Disease and Blood Purification in Hunan, Changsha 410011, PR China. Electronic address:
    Acute kidney injury (AKI) is an increasingly common disorder that is strongly linked to short- and long-term morbidity and mortality. During AKI process, macrophages, one of the important immune response cells, can polarize into M1 and M2 subtype from M0 subtype. It is well-known that M1 macrophages play a pro inflammatory role while M2 macrophages play an anti-inflammatory role. Read More

    Identification of NTRK3 Fusions in Childhood Melanocytic Neoplasms.
    J Mol Diagn 2017 May;19(3):387-396
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
    Spitzoid neoplasms are a distinct group of melanocytic tumors. Genetically, they lack mutations in common melanoma-associated oncogenes. Recent studies have shown that spitzoid tumors may contain a variety of kinase fusions, including ROS1, NTRK1, ALK, BRAF, and RET fusions. Read More

    Demyelinating polyradiculoneuropathy under combined BRAF/MEK inhibitors.
    Eur J Cancer 2017 Apr 19;78:103-104. Epub 2017 Apr 19.
    Department of Dermatology, Lyon Sud University Hospital, Hospices Civils de Lyon, France; Cancer Research Center of Lyon, INSERM U1052, CNRS UMR5286, Lyon, France; Claude Bernard Lyon 1 University, Lyon, France. Electronic address:

    Prognostics factors and survival in acral lentiginous melanoma.
    Br J Dermatol 2017 Apr 22. Epub 2017 Apr 22.
    Division of Research, Kaiser Permanente Northern California, Oakland, California.
    Background: Acral lentiginous melanoma is a rare melanoma subtype that disproportionately afflicts people of color. Acral lentiginous melanomas have a worse prognosis than other melanomas subtypes, which has been attributed to aggressive biological behavior, more advanced stage at presentation and possible disparities in access to healthcare.

    Objectives: Using comprehensive patient data and long-term follow-up information in a well-characterized cohort, to examine how patient, tumor, and clinical management variables impact overall and melanoma-specific survival. Read More

    Para-atrial non-acute mediastinal hematoma after left atrial maze procedure mimicking tumor in a patient with treated melanoma.
    J Nucl Cardiol 2017 Apr 21. Epub 2017 Apr 21.
    Department of Radiology, Augusta University Medical Center, 1120 15th St, Augusta, GA, 30912, USA.
    Introduction: The Cox Maze III procedure is considered the gold standard open surgical procedure for management of atrial fibrillation. This article outlines a unique case of a para-atrial mediastinal hematoma following a bilateral thoracoscopic left atrial Maze procedure mimicking malignancy.

    Report: A 60-year-old male, with past history of melanoma, underwent bilateral thoracoscopic left atrial mini maze procedure with radiofrequency energy and exclusion of the left atrial appendage. Read More

    Rationale for New Checkpoint Inhibitor Combinations in Melanoma Therapy.
    Am J Clin Dermatol 2017 Apr 21. Epub 2017 Apr 21.
    Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
    The use of monoclonal antibodies that block immunologic checkpoints, which mediate adaptive immune resistance, has revolutionized the treatment of metastatic melanoma patients. Specifically, targeting single immune suppressive molecules such as cytotoxic T lymphocyte-associated protein 4 (CTLA-4), or programmed cell death protein 1 (PD-1) expressed on T cells or its primary ligand, programmed cell death ligand 1 (PD-L1), resulted in pronounced clinical benefit for a subset of melanoma patients. Although single-agent immune checkpoint inhibitor therapy has demonstrated promising clinical activity in metastatic melanoma patients, there is still a significant proportion of patients who show primary resistance to these therapies. Read More

    Effects of Agaricus blazei Murill Polysaccharide on Cadmium Poisoning on the MDA5 Signaling Pathway and Antioxidant Function of Chicken Peripheral Blood Lymphocytes.
    Biol Trace Elem Res 2017 Apr 21. Epub 2017 Apr 21.
    Northeast Agricultural University, Harbin, 150030, People's Republic of China.
    This experimental study investigated the effect of Agaricus blazei Murill polysaccharide (ABP) on cadmium (Cd) poisoning on the melanoma differentiation-associated gene 5 (MDA5) signaling pathway and antioxidant function of peripheral blood lymphocytes (PBLs) in chickens. The experiments were divided into four groups: 7-day-old chickens with normal saline (0.2 mL single/day), Cd (140 mg/kg), ABP (30 mg/mL, 0. Read More

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