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    1 OF 2286

    Multiple Lymph Node Basin Drainage in Trunk Melanoma Is Not Associated with Survival of Sentinel Lymph Node-Positive Patients.
    Dermatology 2017 Jul 25. Epub 2017 Jul 25.
    Dermatologic Clinic, Medical Sciences Department, University of Turin, Turin, Italy.
    Objectives: This study was aimed at investigating the prognostic role of multiple lymph node basin drainage (MLBD) in patients with positive sentinel lymph node (SLN) biopsy.

    Background: MLBD is frequently observed in patients with trunk melanoma undergoing SLN. The prognostic value of MLBD in SLN-positive patients is still debated. Read More

    P53 and MITF/Bcl-2 identified as key pathways in the acquired resistance of NRAS-mutant melanoma to MEK inhibition.
    Eur J Cancer 2017 Jul 21;83:154-165. Epub 2017 Jul 21.
    Laboratory of Oncology and Experimental Surgery, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium. Electronic address:
    Activating mutations in Neuroblastoma RAS viral oncogene homolog (NRAS) are found in 15-30% of melanomas and are associated with a poor prognosis. Although MAP kinase kinase (MEK) inhibitors used as single agents showed a limited clinical benefit in patients with NRAS-mutant melanoma due to their rather cytostatic effect and high toxicity, their combination with other inhibitors of pathways known to cooperate with MEK inhibition may maximise their antitumour activity. Similarly, in a context where p53 is largely inactivated in melanoma, hyperexpression of Microphthalmia associated transcription factor (MITF) and its downstream anti-apoptotic targets may be the cause of the restraint cytotoxic effects of MEK inhibitors. Read More

    Periprosthetic seroma with false-positive FDG PET-CT reactive nodes mistaken for metastases in a patient previously treated of metastasic melanoma. Potential source of diagnostic errors.
    Int J Surg Case Rep 2017 Jul 8;38:66-68. Epub 2017 Jul 8.
    Department of General Surgery and Digestive Diseases, University Hospital of Araba, Spain. Electronic address:
    Introduction: FDG PET/CT is believed to be crucial in oncology, but its limited specificity represents a challenge. Prosthetic meshes used for repair abdominal defects may lead to false-positives FDG PET/CT uptake, over staging malignancies and inducing inappropriate treatments. A false-positive FDG PET/CT uptake mimicking metastatic disease during the follow-up of a previously treated metastatic melanoma patient is presented. Read More

    Advances in Melanoma: The Rationale for the Melanoma Nursing Initiative
.
    Clin J Oncol Nurs 2017 Aug;21(4):7-10
    Massachusetts General Hospital Cancer Center.
    This article provides an overview of this supplement, outlining the needs assessment process the Melanoma Nursing Initiative (MNI) used to determine the immunotherapy and targeted therapy topics for discussion as well as the process for developing the consensus statements. The article provides specific discussion of a unique feature of the MNI, the care step pathways (CSPs) for management of adverse events (AEs) associated with melanoma therapies, and looks to the future in terms of the potential benefits of engaging and enabling oncology nurses to adopt a standardized approach to AE management and adherence promotion for melanoma therapies. Read More

    PD-1 Inhibitor Therapy: Consensus Statement From the Faculty of the Melanoma Nursing Initiative on Managing Adverse Events
.
    Clin J Oncol Nurs 2017 Aug;21(4):42-51
    Massachusetts General Hospital Cancer Center.
    Background: Programmed cell death protein 1 (PD-1) inhibitor therapies are now a standard treatment for advanced melanoma and other tumor types. The immune-related adverse events (irAEs) associated with PD-1 inhibitor therapy are drastically different from the AEs associated with chemotherapy. Because these irAEs reflect immune system activation rather than side effects of therapy, nurses should be cognizant of the range of organ systems potentially affected as well as likely clinical presentations. Read More

    Ipilimumab-Based
 Therapy: Consensus Statement From the Faculty of the Melanoma Nursing Initiative on Managing Adverse Events With Ipilimumab Monotherapy and Combination Therapy With Nivolumab.
    Clin J Oncol Nurs 2017 Aug;21(4):30-41
    University of Colorado Cancer Center.
    Background: Ipilimumab (Yervoy®) therapy improves outcomes in patients with resected stage III melanoma, and ipilimumab alone or combined with nivolumab (Opdivo®) does so in those with unresectable or metastatic melanoma. These immunotherapies are associated with immune-related adverse events (irAEs). With prompt recognition and appropriate management, serious sequelae or unnecessary treatment discontinuation can be prevented. Read More

    Promoting Oral Therapy Adherence: Consensus Statements From the Faculty of the Melanoma Nursing Initiative on Oral Melanoma Therapies
.
    Clin J Oncol Nurs 2017 Aug;21(4):87-96
    Tennessee Oncology.
    Background: Inhibitors of BRAF and the downstream signaling protein MEK have improved outcomes for patients with BRAF-mutant advanced malignant melanoma. Despite their ease of administration, these oral therapies pose adherence challenges. 
. Read More

    Collaborative Care in Melanoma: The Essential Role of the Nurse
.
    Clin J Oncol Nurs 2017 Aug;21(4):4-6
    University of California, Los Angeles Jonsson Comprehensive Cancer Center.
    This article provides perspective from medical oncologists on the importance of this supplement from the Melanoma Nursing Initiative. The authors (a) delineate the challenges inherent in addressing adverse event (AE) management with newer melanoma therapies, particularly in the community setting; (b) illustrate how advanced practice providers with extensive clinical trial experience in melanoma are in a key position to set the agenda and educate colleagues on best practices in AE management; and Read More

    BRAF/MEK 
Inhibitor Therapy: Consensus Statement From the Faculty of the Melanoma Nursing Initiative on Managing Adverse Events and Potential Drug Interactions.
    Clin J Oncol Nurs 2017 Aug;21(4):11-29
    Moffitt Cancer Center.
    Background: BRAF/MEK inhibitor therapy improves outcomes in BRAF V600E- and V600K-mutated unresectable or metastatic melanoma. However, these regimens are associated with adverse events (AEs) that may lead to unnecessary drug modifications and discontinuations or potentially serious sequelae. In addition, drug-drug interactions (DDIs) may result in AEs or altered therapeutic efficacy. Read More

    Clinical Nurse Consultant Support: Management of Patients With Melanoma Receiving Immunotherapy 
and Targeted Therapy
.
    Clin J Oncol Nurs 2017 Aug;21(4):E93-E98
    Chris O'Brien Lifehouse.
    Background: Targeted therapy and immunotherapy agents for advanced melanoma are associated with novel toxicities. Melanoma clinical nurse consultants (CNCs) provide multifaceted clinical care.
. Read More

    Resident memory T cells in the skin mediate durable immunity to melanoma.
    Sci Immunol 2017 Apr;2(10)
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
    Tissue-resident memory T (TRM) cells have been widely characterized in infectious disease settings; however, their role in mediating immunity to cancer remains unknown. We report that skin-resident memory T cell responses to melanoma are generated naturally as a result of autoimmune vitiligo. Melanoma antigen-specific TRM cells resided predominantly in melanocyte-depleted hair follicles and were maintained without recirculation or replenishment from the lymphoid compartment. Read More

    Melanoma subtypes demonstrate distinct PD-L1 expression profiles.
    Lab Invest 2017 Jul 24. Epub 2017 Jul 24.
    Department of Dermatology, Johns Hopkins University School of Medicine, Bloomberg Kimmel Institute for Cancer Immunotherapy, and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
    PD-L1 expression in the tumor immune microenvironment is recognized as both a prognostic and predictive biomarker in patients with cutaneous melanoma, a finding closely related to its adaptive (IFN-γ-mediated) mechanism of expression. Approximately 35% of cutaneous melanomas express PD-L1, however, the expression patterns, levels, and prevalence in rarer melanoma subtypes are not well described. We performed immunohistochemistry for PD-L1 and CD8 on 200 formalin-fixed paraffin-embedded specimens from patients with acral (n=16), mucosal (n=36), uveal (n=103), and chronic sun-damaged (CSD) (n=45) melanomas (24 lentigo maligna, 13 'mixed' desmoplastic, and 8 'pure' desmoplastic melanomas). Read More

    The Role of p16(INK4a) Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer.
    Int J Mol Sci 2017 Jul 22;18(7). Epub 2017 Jul 22.
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico (IDI-IRCCS), Fondazione Luigi Maria Monti (FLMM), via Monti di Creta 104, 00167 Rome, Italy.
    The epidermis is a self-renewing tissue. The balance between proliferation and differentiation processes is tightly regulated to ensure the maintenance of the stem cell (SC) population in the epidermis during life. Aging and cancer may be considered related endpoints of accumulating damages within epidermal self-renewing compartment. Read More

    Sarcoidosis Following Anti-PD-1 and Anti-CTLA-4 Therapy for Metastatic Melanoma.
    J Immunother 2017 Jul 21. Epub 2017 Jul 21.
    *Department of Surgery, Section of Surgical Oncology †Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine ‡Department of Internal Medicine, Section of Medical Oncology Departments of §Dermatology ∥Pathology, Yale University School of Medicine, New Haven, CT.
    Immune checkpoint inhibitors represent the newest treatment for stage IV melanoma. These agents are generally well tolerated, however severe immune-related adverse effects have been noted in a small, but clinically significant percentage of patients. Specifically, sarcoidosis is a known potential complication following anti-CTLA-4 therapy. Read More

    Detection theory for accurate and non-invasive skin cancer diagnosis using dynamic thermal imaging.
    Biomed Opt Express 2017 Apr 22;8(4):2301-2323. Epub 2017 Mar 22.
    Center for High Technology Materials, University of New Mexico, 1313 Goddard Street SE, MSC04 2710, Albuquerque, NM 87106-4343, USA.
    Skin cancer is the most common cancer in the United States with over 3.5M annual cases. Presently, visual inspection by a dermatologist has good sensitivity (> 90%) but poor specificity (< 10%), especially for melanoma, which leads to a high number of unnecessary biopsies. Read More

    Identification of melanoma cells: a method based in mean variance of signatures via spectral densities.
    Biomed Opt Express 2017 Apr 15;8(4):2185-2194. Epub 2017 Mar 15.
    Departamento de Ciencias Químico Biológicas, Universidad de Sonora (UNISON), Luis Encinas y Rosales S/N, Col. Centro, C.P. 83000, Hermosillo, Sonora, Mexico.
    In this paper a new methodology to detect and differentiate melanoma cells from normal cells through 1D-signatures averaged variances calculated with a binary mask is presented. The sample images were obtained from histological sections of mice melanoma tumor of 4 [Formula: see text] in thickness and contrasted with normal cells. The results show that melanoma cells present a well-defined range of averaged variances values obtained from the signatures in the four conditions used. Read More


    Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model.
    Front Pharmacol 2017 7;8:319. Epub 2017 Jul 7.
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of ViennaVienna, Austria.
    Deregulation of NOTCH2 signaling is implicated in a wide variety of human neoplasias. The current concept of targeting NOTCH is based on using gamma secretase inhibitors (GSI) to regulate the release of the active NOTCH intracellular domain. However, the clinical outcome of GSI remains unsatisfactory. Read More

    HLA-A*26 is correlated with response to nivolumab in Japanese melanoma patients.
    J Invest Dermatol 2017 Jul 20. Epub 2017 Jul 20.
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, 139668, Singapore. Electronic address:

    Continued increase in melanoma incidence across all socioeconomic status groups in California, 1998-2012.
    J Invest Dermatol 2017 Jul 20. Epub 2017 Jul 20.
    Department of Dermatology, Pigmented Lesion and Melanoma Program, Stanford University Medical Center and Cancer Institute, Stanford, CA; and Dermatology Service, VA Palo Alto Health Care System, Palo Alto, CA. Electronic address:
    Melanoma incidence has been increasing in light-skinned populations worldwide, but the reasons for the increase have been controversial. Our prior assessment in California non-Hispanic whites showed substantial increases in invasive melanoma incidence for tumors of all thicknesses in all neighborhoods categorized by socioeconomic status (SES) between 1988-1992 and 1998-2002. To understand whether these trends continued, we updated our assessment to include the diagnosis period 2008-2012 and more accurate pathologic stage at diagnosis. Read More

    Serial or Parallel Metastasis of Cutaneous Melanoma? A Study of the German Central Malignant Melanoma Registry.
    J Invest Dermatol 2017 Jul 20. Epub 2017 Jul 20.
    Center for Dermatooncology, Department of Dermatology, Eberhard-Karls-University of Tuebingen, Tuebingen, Germany; Central Malignant Melanoma Registry, Eberhard-Karls-University of Tuebingen, Tuebingen, Germany. Electronic address:
    For more than a century the Halstedian hypothesis of contiguous metastasis from the primary tumor through the lymphatics to distant sites shaped the lymph node surgery for melanoma. We challenge this dogma of serial metastatic dissemination. A single-center series of 2299 patients with cutaneous metastatic melanoma was investigated to analyze overall survival (OS) and distant metastasis-free survival (DMFS) of stage IV patients with or without primary lymphatic metastasis. Read More

    Fluctuations in routine blood count might signal severe immune-related adverse events in melanoma patients treated with nivolumab.
    J Dermatol Sci 2017 Jul 16. Epub 2017 Jul 16.
    Department of Dermato-Oncology/Dermatology, National Hospital Organization Kagoshima Medical Center, Japan.
    Background: Although nivolumab significantly prolongs survival of metastatic melanoma, about 10% of patients experience severe, even fatal immune-related adverse events (irAEs). Biomarkers to predict irAEs are, therefore, of great interest.

    Objective: We aimed to correlate changes in routine blood count parameters to the occurrence of serious irAEs (grade 3/4 [G3/4] or lung/gastrointestinal [lung/GI] irAEs) in patients with melanoma who were treated with nivolumab. Read More

    Immunotherapy targeting immune check-point(s) in brain metastases.
    Cytokine Growth Factor Rev 2017 Jul 13. Epub 2017 Jul 13.
    Medical Oncology and Immunotherapy, Center for Immuno-Oncology, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy.
    Immunotherapy with monoclonal antibodies (mAb) directed to different immune check-point(s) is showing a significant clinical impact in a growing number of human tumors of different histotype, both in terms of disease response and long-term survival patients. In this rapidly changing scenario, treatment of brain metastases remains an high unmeet medical need, and the efficacy of immunotherapy in these highly dismal clinical setting remains to be largely demonstrated. Nevertheless, up-coming observations are beginning to suggest a clinical potential of cancer immunotherapy also in brain metastases, regardless the underlying tumor histotype. Read More

    Immunohistochemical Expression of MCAM/CD146 in Canine Melanoma.
    J Comp Pathol 2017 Jul 7;157(1):27-33. Epub 2017 Jun 7.
    Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan; Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafr ElSheikh University, Egypt. Electronic address:
    MCAM/CD146 (melanoma cell adhesion molecule/CD146) is a transmembrane immunoglobulin superfamily cell adhesion molecule involved in transendothelial migration and signal transduction. It is expressed in melanoma, squamous cell carcinoma, prostatic, ovarian, cervical and endometrial cancers and promotes tumour growth, angiogenesis and metastasis. Melanoma is the most common malignant oral tumour of dogs and also arises in the skin, nail bed and footpad. Read More

    Surgical Management of Periocular Cancers: High- and Low-Risk Features Drive Treatment.
    Curr Oncol Rep 2017 Sep;19(9):57
    Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1445, Houston, TX, 77030, USA.
    Purpose Of Review: Recent advances in the treatment of eyelid tumors have centered on the excision, evaluation of margins, role of sentinel lymph node biopsy, and adjunctive/adjuvant systemic and radiation therapy. The purpose of this review is to elaborate on these advances.

    Recent Findings: Mohs excision of basal cell carcinoma and squamous cell carcinoma continues to provide the greatest success in complete excision of the cancer, especially in those cases of high-risk disease including medial canthal location and recurrent disease. Read More

    Tumor-infiltrating lymphocytes in breast cancer according to tumor subtype: Current state of the art.
    Breast 2017 Jul 20;35:142-150. Epub 2017 Jul 20.
    Department of Medicine, Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium. Electronic address:
    The recent success of the immune checkpoint blockade in cancer immunotherapy has modified the treatment algorithms in a variety of aggressive neoplastic diseases. Nevertheless, optimal selection of ideal candidates to these drugs remains a challenge. The presence, location and composition of a pre-existing tumor immune infiltrate seem to impact on the benefit from these treatments. Read More

    Survival patterns of 5750 SRS-treated brain metastasis patients as a function of the number of lesions.
    World Neurosurg 2017 Jul 19. Epub 2017 Jul 19.
    Center for Translational and Applied Neuro-Oncology, Department of Neurosurgery, University of California, San Diego, La Jolla, USA. Electronic address:
    Background: The number of brain metastases (BM) plays an important role in the decision between stereotactic radiosurgery (SRS) and whole brain radiation therapy (WBRT).

    Methods: We analyzed the survival of 5750 SRS-treated BM patients as a function of BM number. Survival analyses were performed using Kaplan-Meier analysis as well as univariate and multivariate Cox proportional hazards models. Read More


    Co-encapsulation of paclitaxel and C6 ceramide in tributyrin-containing nanocarriers improve co-localization in the skin and potentiate cytotoxic effects in 2D and 3D models.
    Eur J Pharm Sci 2017 Jul 19. Epub 2017 Jul 19.
    Institute of Biomedical Sciences, University of São Paulo, Brazil. Electronic address:
    Considering that tumor development is generally multifactorial, therapy with a combination of agents capable of potentiating cytotoxic effects is promising. In this study, we co-encapsulated C6 ceramide (0.35%) and paclitaxel (0. Read More

    TLR3 Blockade in Rhinovirus-Induced Experimental Asthma Exacerbations: A Randomized Controlled Study.
    J Allergy Clin Immunol 2017 Jul 19. Epub 2017 Jul 19.
    Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom.
    Background: Human rhinoviruses (HRV) commonly precipitate asthma exacerbations. TLR3, an innate pattern-recognition receptor, is triggered by HRV driving inflammation that may worsen asthma.

    Objective: To evaluate an inhibitory monoclonal antibody to TLR3, CNTO3157, on experimental HRV-16 inoculation in healthy and asthmatic subjects. Read More

    Novel Menadione Hybrids: Synthesis, anticancer activity and cell based studies.
    Chem Biol Drug Des 2017 Jul 22. Epub 2017 Jul 22.
    Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.
    A series of novel menadione based triazole hybrids were designed and synthesized by employing copper catalyzed azide-alkyne cycloaddition (CuAAC). All the synthesized hybrids were characterized by their spectral data ((1) H NMR, (13) C NMR, IR and HRMS). The synthesized compounds were evaluated for their anticancer activity against five selected cancer cell lines including lung (A549), prostate (DU-145), cervical (Hela), breast (MCF-7) and mouse melanoma (B-16) by using MTT assay. Read More

    KIT Mutations and CD117 Overexpression Are Markers of Better Progression-Free Survival in Vulvar Melanomas.
    Br J Dermatol 2017 Jul 22. Epub 2017 Jul 22.
    Departments of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
    Background: Few studies have addressed prognostic markers and none has correlated molecular status and prognosis in vulvar melanomas.

    Objectives And Methods: We evaluated the clinicopathologic features of 95 cases. p53, CD117, Ki-67, neurofibromin, brafv600e, and nrasq61r immunostains; and molecular analyses by either targeted next generation or direct sequencing were performed on available archival materials. Read More

    Novel clinical and molecular findings in Spanish patients with Nevoid Basal Cell Carcinoma Syndrome.
    Br J Dermatol 2017 Jul 22. Epub 2017 Jul 22.
    Molecular Medicine Unit-Department of Medicine, University of Salamanca, Salamanca, Spain.
    Background: Nevoid Basal Cell Carcinoma Syndrome (NBCCS) is an autosomal dominant disorder characterised by developmental alterations and multiple basal cell carcinomas. Mutations in PTCH1, a membrane receptor for Sonic Hedgehog, are associated with the development of the disease. Most of them produce a truncated protein which is unable to supress Smoothened protein and continuously activates the downstream pathway OBJECTIVES: We aimed to characterize 22 unrelated Spanish subjects with NBCCS, the largest cohort of Gorlin syndrome reported to date in Spain METHODS AND RESULTS: We reported for the first time two young patients with uterus didelphys and ganglioneuroma, within the context of NBCCS. Read More

    Inhibitory effect and mechanism of mesenchymal stem cells on melanoma cells.
    Clin Transl Oncol 2017 Jul 21. Epub 2017 Jul 21.
    College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, 100044, People's Republic of China.
    Purpose: To explore the inhibitory effect and mechanism of MSCs on melanoma proliferation.

    Methods: The inhibitory effect of MSCs on melanoma A375 cells was detected by co-culture and conditioned medium (CM) experiments using MTT method. The cell cycle was analyzed by flow cytometry. Read More

    Implementation of a model-based design in a phase 1b study of combined targeted agents.
    Clin Cancer Res 2017 Jul 21. Epub 2017 Jul 21.
    Public Health Sciences, University of Virginia.
    In recent years, investigators have recognized the rigidity of single agent, safety only, traditional designs, rendering them ineffective for conducting contemporary early-phase clinical trials, such as those involving combinations and /or biological agents.  Novel approaches are required to address these research questions, such as those posed in trials involving targeted therapies. We describe the implementation of a model-based design for identifying an optimal treatment combination, defined by low toxicity and high efficacy, in an early-phase trial evaluating a combination of two oral targeted inhibitors in relapsed / refractory mantle cell lymphoma. Read More

    TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: an Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence.
    Cancer Discov 2017 Jul 21. Epub 2017 Jul 21.
    Genomic Medicine, University of Texas MD Anderson Cancer Center
    Genomic intratumor heterogeneity (ITH) may be associated with postsurgical relapse of localized lung adenocarcinomas. Recently, mutations, through generation of neoantigens were shown to alter tumor immunogenicity through T cell responses. Here, we performed sequencing of the T cell receptor (TCR) in 45 tumor regions from 11 localized lung adenocarcinomas and observed substantial intratumor differences in T cell density and clonality with the majority of T cell clones restricted to individual tumor regions. Read More

    Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance.
    Cancer Immunol Res 2017 Jul 21. Epub 2017 Jul 21.
    Ludwig Institute for Cancer Research, Brussels, Belgium.
    Tumors use various mechanisms to avoid immune destruction. Cyclooxygenase-2 (COX-2) expression may be a driver of immune suppression in melanoma, but the mechanisms involved remain elusive. Here, we show that COX-2 expression drives constitutive expression of indoleamine 2,3-dioxygenase 1 (IDO1) in human tumor cells. Read More

    Synapsin-antibodies in psychiatric and neurological disorders: prevalence and clinical findings.
    Brain Behav Immun 2017 Jul 18. Epub 2017 Jul 18.
    Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address:
    Objective: To study the prevalence of autoantibodies to synapsin in patients with psychiatric and neurological disorders and to describe clinical findings in synapsin antibody positive patients.

    Methods: Sera of 375 patients with different psychiatric and neurological disorders and sera of 97 healthy controls were screened (dilution 1:320) for anti-synapsin IgG using HEK293 cells transfected with rat synapsin Ia. Positive sera were further analyzed by immunoblots with brain tissue from wild type and synapsin knock out mice and with HEK293 cells transfected with human synapsin Ia and Ib. Read More

    Novel Additions to the AJCC's New Staging Systems for Skin Cancer.
    Actas Dermosifiliogr 2017 Jul 18. Epub 2017 Jul 18.
    Servicio de Dermatología, Complejo Asistencial Universitario de Salamanca, Salamanca, España; IBSAL Instituto de Investigación Biomédica de Salamanca, Complejo Asistencial Universitario de Salamanca, Salamanca, España.
    The eighth edition of the staging manual of the American Joint Committee on Cancer incorporates important changes in the classification of skin cancers. Coming 40 years after the first edition, the latest manual preserves its specific system for Merkel cell carcinoma and takes into account recent publications on the prognosis of squamous cell carcinoma by defining a completely new T category for this neoplasm. Staging for squamous cell carcinoma considers head and neck tumors (excluding the eyelid) and does not offer solutions for other sites except the vulva, penis, and perianal region. Read More

    Uncommon Neoplasms of the biliary tract: Radiological Findings.
    Br J Radiol 2017 Jul 21:20160561. Epub 2017 Jul 21.
    1 Department of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale, IRCCS di Napoli, Naples, Italy.
    Objectives: To report our cancer center experience in the biliary tumors incidence other than cholangiocellular-carcinoma (CCC), emphasizing the radiological features.

    Methods: 197 patients with biliary disease undergoing Gd-EOB-DTPA-enhanced MRI were reviewed. Four radiologists evaluated retrospectively size, structure, anatomical site, and signal intensity of lesions on MRI. Read More

    Clinical significance of miR-138 in patients with malignant melanoma through targeting of PDK1 in the PI3K/AKT autophagy signaling pathway.
    Oncol Rep 2017 Jul 19. Epub 2017 Jul 19.
    Department of Immuno-oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
    The present study investigated the clinical significance of miR-138 in patients with malignant melanoma (MM), which has previously been associated with tumor growth. In patients with MM, we found that the expression of miR-138 was significantly downregulated when compared with healthy control subjects. Overexpression of miR-138 in the human melanoma cell line A2058 inhibited cell proliferation and induced cell apoptosis, and increased caspase-3 and Bax protein expression when compared with a negative control group. Read More

    Molecular genetics and targeted therapy of WNT-related human diseases (Review).
    Int J Mol Med 2017 Jul 19. Epub 2017 Jul 19.
    Department of Omics Network, National Cancer Center, Tokyo 104-0045, Japan.
    Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the WNT/β-catenin and WNT/stabilization of proteins (STOP) signaling cascades to regulate cell fate and proliferation, whereas non-canonical WNT signaling through Frizzled or ROR receptors is transduced to the WNT/planar cell polarity (PCP), WNT/G protein-coupled receptor (GPCR) and WNT/receptor tyrosine kinase (RTK) signaling cascades to regulate cytoskeletal dynamics and directional cell movement. WNT/β-catenin signaling cascade crosstalks with RTK/SRK and GPCR-cAMP-PKA signaling cascades to regulate β-catenin phosphorylation and β-catenin-dependent transcription. Germline mutations in WNT signaling molecules cause hereditary colorectal cancer, bone diseases, exudative vitreoretinopathy, intellectual disability syndrome and PCP-related diseases. Read More

    Neurotropic melanoma: an analysis of the clinicopathological features, management strategies and survival outcomes for 671 patients treated at a tertiary referral center.
    Mod Pathol 2017 Jul 21. Epub 2017 Jul 21.
    Melanoma Institute Australia, The University of Sydney, North Sydney, NSW, Australia.
    Neurotropic cutaneous melanoma is a rare melanoma subtype that invades nerves and is often associated with desmoplastic melanoma. Limited data suggest that it has a greater propensity to recur locally, but it is unknown whether its behavior differs from that of other melanoma subtypes, including desmoplastic melanoma. We investigated clinicopathological predictors of outcome in a cohort of 671 patients with neurotropic melanoma to develop evidence-based management recommendations. Read More

    Computer-assisted measurement of primary tumor area is prognostic of recurrence-free survival in stage IB melanoma patients.
    Mod Pathol 2017 Jul 21. Epub 2017 Jul 21.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.
    Current staging guidelines are insufficient to predict which patients with thin primary melanoma are at high risk of recurrence. Computer-assisted image analysis may allow for more practical and objective histopathological analysis of primary tumors than traditional light microscopy. We studied a prospective cohort of stage IB melanoma patients treated at NYU Langone Medical Center from 2002 to 2014. Read More

    Tumor infiltrating lymphocytes as a prognostic factor in malignant melanoma. Review of the literature.
    J BUON 2017 May-Jun;22(3):592-598
    Surgical and Gynecologic Oncology, Department 11 - Oncology, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca.
    Malignant melanoma represents the major cause of mortality among skin cancers, with increasing incidence and mortality rates worldwide. Despite the numerous public health campaigns and the efforts undertaken in the last decade regarding the establishment of a rapid diagnostic and an efficient treatment for these patients, the long-term prognosis has not been significantly improved. Thus, numerous studies were conducted in order to establish a more accurate prognosis, tumor infiltrating lymphocytes (TILs) being considered in many studies as independent prognostic factors of lymph node metastasis and overall survival in patients with melanoma. Read More

    Chest wall lymphomas: Fine needle aspiration cytodiagnosis and review of the literature.
    Cytopathology 2017 Jul 21. Epub 2017 Jul 21.
    Cytology Unit, Mubarak Al-Kabeer Hospital, Al-Jabriya, Kuwait.
    Objective: Compared to other chest wall malignancies, lymphoma is a common disease. However, published literature on a series of lymphoma cases involving the chest wall is scarce. The aim of the present study, was to describe experience with chest wall swellings diagnosed as lymphoid neoplasms on fine needle aspiration (FNA) cytology. Read More

    [Malignant melanoma : Current status].
    Radiologe 2017 Jul 20. Epub 2017 Jul 20.
    Nationales Centrum für Tumorerkrankungen, Universitätshautklinik, Im Neuenheimer Feld 460, 69120, Heidelberg, Deutschland.
    Clinical Issue: The incidence of malignant melanoma is continuously increasing. The prognosis of metastatic disease is still limited.

    Standard Treatment: Until a few years ago palliative chemotherapy with a limited response rate was the standard treatment for metastatic melanoma. Read More

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