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    Polyisocyanopeptide hydrogels: a novel thermo-responsive hydrogel supporting pre-vascularization and the development of organotypic structures.
    Acta Biomater 2018 Feb 14. Epub 2018 Feb 14.
    Tissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, August Forel Str. 7, CH-8008 Zurich, Switzerland. Electronic address:
    Molecular and mechanical interactions with the 3D extracellular matrix are essential for cell functions such as survival, proliferation, migration, and differentiation. Thermo-responsive biomimetic polyisocyanopeptide (PIC) hydrogels are promising new candidates for 3D cell, tissue, and organ cultures. This is a synthetic, thermo-responsive and stress-stiffening material synthesized via polymerization of the corresponding monomers using a nickel perchlorate as a catalyst. Read More

    Laser-assisted delivery of synergistic combination chemotherapy in in vivo skin.
    J Control Release 2018 Feb 14. Epub 2018 Feb 14.
    Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, NV 2400, Denmark.
    The effectiveness of topical drugs for treatment of non-melanoma skin cancer is greatly reduced by insufficient penetration to deep skin layers. Ablative fractional lasers (AFLs) are known to enhance topical drug uptake by generating narrow microchannels through the skin, but information on AFL-drug delivery in in vivo conditions is limited. In this study, we examined pharmacokinetics, biodistribution and toxicity of two synergistic chemotherapy agents, cisplatin and 5-fluorouracil (5-FU), following AFL-assisted delivery alone or in combination in in vivo porcine skin. Read More

    Examining the Incidence and Presentation of Melanoma in the Cardiothoracic Transplant Population.
    JAMA Dermatol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Surgery, Duke University Medical Center, Durham, North Carolina.
    Importance: The immunosuppression vital to maintaining transplanted organs comes with an increased incidence of cutaneous neoplasms. Understanding the genesis of malignant melanoma (MM) in transplant subpopulations is necessary for adequate disease surveillance.

    Objective: To determine the incidence and timing of presentation of MM in the cardiothoracic (heart and/or lung) transplant (CTT) population. Read More

    A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma.
    Pigment Cell Melanoma Res 2018 Feb 17. Epub 2018 Feb 17.
    Rutgers Cancer Institute of New Jersey/Robert Wood Johnson Medical School, New Brunswick, NJ.
    Studies demonstrate that GRM, expressed by >60% of human melanomas, may be a therapeutic target. We performed a phase II trial of 100 mg po bid of riluzole, an inhibitor of GRM1 signaling, in patients with advanced melanoma with the primary endpoint of response rate. Thirteen patients with GRM1-positive tumors were enrolled. Read More

    The impact of timing of immunotherapy with cranial irradiation in melanoma patients with brain metastases: intracranial progression, survival and toxicity.
    J Neurooncol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 30 Fruit Street, Boston, MA, 02114, USA.
    Immunotherapy (IT) is increasingly incorporated in the management of metastatic melanoma patients with brain metastases, but the impact of timing of IT with stereotactic radiosurgery (SRS) remains unclear. The aim of this study was to determine the temporal significance of IT in melanoma patients treated with cranial radiation therapy (RT) with respect to patterns of intracranial progression, overall survival (OS), and toxicity. We retrospectively reviewed consecutive melanoma patients with brain metastases undergoing cranial RT and IT between 2008 and 2015. Read More

    Comparative study of phototoxicity of protoporphyrin IX synthetic and extracted from ssp Rattus novergicus albinus rats toward murine melanoma cells.
    Eur Biophys J 2018 Feb 16. Epub 2018 Feb 16.
    Physics Department, Faculty of Philosophy, Sciences and Letters of Ribeirao Preto, University of Sao Paulo (USP), Ribeirao Preto, Brazil.
    Protoporphyrin IX (PpIX) is a precursor of heme synthesis and is known to be an active photosensitizer and precursor of photosensitizers applied in photodynamic therapy (PDT) and photodynamic diagnostics (PDD). On irradiation with visible light, PpIX undergoes phototransformation, producing photoproducts which may also be phototoxic and increase its efficacy. The mechanism of PpIX phototransformation depends on environmental characteristics and can be different in vitro and in vivo. Read More

    In vitro studies of DNA damage and repair mechanisms induced by BNCT in a poorly differentiated thyroid carcinoma cell line.
    Radiat Environ Biophys 2018 Feb 16. Epub 2018 Feb 16.
    Radiobiology Department (CAC, CNEA), 1499 Gral Paz Av, Buenos Aires, Argentina.
    Boron neutron capture therapy (BNCT) for aggressive tumors is based on nuclear reaction [B (n, α)Li]. Previously, we demonstrated that BNCT could be applied for the treatment of undifferentiated thyroid carcinoma. The aim of the present study was to describe the DNA damage pattern and the repair pathways that are activated by BNCT in thyroid cells. Read More

    Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy.
    Proc Natl Acad Sci U S A 2018 Feb 16. Epub 2018 Feb 16.
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114;
    A subset of patients with metastatic melanoma have sustained remissions following treatment with immune checkpoint inhibitors. However, analyses of pretreatment tumor biopsies for markers predictive of response, including PD-1 ligand (PD-L1) expression and mutational burden, are insufficiently precise to guide treatment selection, and clinical radiographic evidence of response on therapy may be delayed, leading to some patients receiving potentially ineffective but toxic therapy. Here, we developed a molecular signature of melanoma circulating tumor cells (CTCs) to quantify early tumor response using blood-based monitoring. Read More

    Recurrent epistaxis leading to diagnosis of primary sinonasal melanoma.
    BMJ Case Rep 2018 Feb 16;2018. Epub 2018 Feb 16.
    Internal Medicine, Saint Joseph Mercy Ann Arbor Hospital, Ypsilanti, Michigan, USA.
    A 48-year-old man presented to urgent care with recurrent epistaxis over 6 months. Initially, nosebleeds were controlled with packing or cautery. Ultimately, he was referred to ear, nose and throat department and underwent nasal endoscopy which revealed polypoid tissue. Read More

    Retina dose as a predictor for visual acuity loss inRu eye plaque brachytherapy of uveal melanomas.
    Radiother Oncol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Ophthalmology and Optometry, Medical University of Vienna/AKH Vienna, Austria.
    Background And Purpose: To evaluate the retina dose as a risk factor associated with loss of visual acuity (VA) inRu plaque brachytherapy.

    Material/methods: 45 patients receivingRu plaques brachytherapy (median follow-up 29.5 months) were included in this study. Read More

    Gene expression screening identifies CDCA5 as a potential therapeutic target in acral melanoma.
    Hum Pathol 2018 Feb 13. Epub 2018 Feb 13.
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing, China. Electronic address:
    Acral melanoma (AM) is a rapidly progressing subtype of melanoma with poor prognosis. The complete array of molecular changes that occur during AM metastasis remains unclear. In this study, we compared the gene expression profiles of six primary and 12 lymph node metastatic AM samples by tissue microarray analysis. Read More

    CYP27A1 acts on the pre-vitamin D3 photoproduct, lumisterol, producing biologically active hydroxy-metabolites.
    J Steroid Biochem Mol Biol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Dermatology, University of Alabama at Birmingham, AL 35294, USA; VA Medical Center, Birmingham, AL 35294, USA.
    Prolonged exposure of the skin to UV radiation causes previtamin D3, the initial photoproduct formed by opening of the B ring of 7-dehydrocholesterol, to undergo a second photochemical reaction where the B-ring is reformed giving lumisterol3 (L3), a stereoisomer of 7-dehydrocholesterol. L3 was believed to be an inactive photoproduct of excessive UV radiation whose formation prevents excessive vitamin D production. Recently, we reported that L3 is present in serum and that CYP11A1 can act on L3 producing monohydroxy- and dihydroxy-metabolites which inhibit skin cell proliferation similarly to 1α,25-dihydroxyvitamin D3. Read More

    [Uveal melanoma, a model disease for splicing alterations and oncogenesis].
    Med Sci (Paris) 2018 Feb 16;34(2):155-160. Epub 2018 Feb 16.
    Inserm U830, Institut Curie, université Paris Sciences et Lettres - PSL Research University, 26, rue d'Ulm, 75248 Cedex Paris, France.
    Uveal melanoma is a rare cancer in adults, whose highly stereotyped oncogenic events have been decrypted over the last decade. Its epidemiological, genetic and transcriptional features make it a remarkable model of oncogenesis. Malignant transformation involves almost mutually exclusive alteration of fundamental biologic pathways, including chromatin regulation with inactivation of BAP1, splicing with mutations of SF3B1 or translation with mutations of EIF1AX. Read More

    Pradimicin-IRD from Amycolatopsis sp. IRD-009 and its antimicrobial and cytotoxic activities.
    Nat Prod Res 2018 Feb 16:1-8. Epub 2018 Feb 16.
    a Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto , Universidade de São Paulo , Ribeirão Preto , Brazil.
    A new polycyclic antibiotic, pradimicin-IRD, was isolated from actinobacteria Amycolatopsis sp. IRD-009 recovered from soil of Brazilian rainforest undergoing restoration area. This molecule is the major compound produced in solid culture media. Read More

    Association of clinicopathological features of melanoma with total naevus count and a history of dysplastic naevi: a cross-sectional retrospective study within an academic centre.
    Clin Exp Dermatol 2018 Feb 16. Epub 2018 Feb 16.
    Pigmented Lesion Clinic and Cutaneous Oncology Program, Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
    Background: High naevus count (HNC) (≥ 50 naevi) and presence of dysplastic naevi (DN) are risk factors for malignant melanoma (MM); however, MMs also occur in patients with low naevus count (LNC) (< 50 naevi) and in patients without DN. Little is known about differences between MMs in these groups.

    Aim: To characterize the clinicopathological differences between MMs in patients with HNC and those in patients with LNC, with or without biopsy-proven DN. Read More

    HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status.
    Invest Ophthalmol Vis Sci 2018 Feb;59(2):1005-1015
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
    Purpose: Antitumor T cells need expression of HLA class I molecules but can be inhibited by ligands such as programmed death ligand 1 (PD-L1). We determined expression and regulation of these molecules in human conjunctival melanoma (CM) samples, cell lines, and murine xenografts.

    Methods: Immunofluorescence staining was performed to examine the expression of HLA-A, HLA-B/C, and β-2-microglobulin (B2M) in 23 primary CM samples. Read More

    The Adhesion G-Protein-Coupled Receptor, GPR56/ADGRG1, Inhibits Cell-Extracellular Matrix Signaling to Prevent Metastatic Melanoma Growth.
    Front Oncol 2018 1;8. Epub 2018 Feb 1.
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, United States.
    Metastatic growth is considered a rate-limiting step in cancer progression, and upregulation of extracellular matrix (ECM) deposition and cell-ECM signaling are major drivers of this process. Mechanisms to reverse ECM upregulation in cancer could potentially facilitate its prevention and treatment but they are poorly understood. We previously reported that the adhesion G-protein-coupled receptor GPR56/ADGRG1 is downregulated in melanoma metastases. Read More

    Targeted therapy of brain metastases: latest evidence and clinical implications.
    Ther Adv Med Oncol 2017 Dec 15;9(12):781-796. Epub 2017 Nov 15.
    Brain Tumor and Neuro-Oncology Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, CA-51, Cleveland, OH 44195, USA.
    Brain metastases (BM) occur in 20-40% of patients with cancer and 60-75% of patients with BM become symptomatic. Due to an aging population and advances in the treatment of primary cancers, patients are living longer and are more likely to experience complications from BM. The diagnosis of BM drastically worsens long-term survival rates, with multiple metastases being a poor prognostic factor. Read More

    TERT promoter mutation in adult granulosa cell tumor of the ovary.
    Mod Pathol 2018 Feb 15. Epub 2018 Feb 15.
    Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.
    The telomerase reverse transcriptase (TERT) gene is highly expressed in stem cells and silenced upon differentiation. Cancer cells can attain immortality by activating TERT to maintain telomere length and telomerase activity, which is a crucial step of tumorigenesis. Two somatic mutations in the TERT promoter (C228T; C250T) have been identified as gain-of-function mutations that promote transcriptional activation of TERT in multiple cancers, such as melanoma and glioblastoma. Read More

    Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway.
    Cell Death Dis 2018 Feb 15;9(3):260. Epub 2018 Feb 15.
    Institute of Aging Research, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, 523808, China.
    Although targeted therapy and immunotherapy greatly improve the outcome of melanoma, drug resistance and low response rates still maintain the unsubstitutability of traditional chemotherapy. Cisplatin (CDDP) is widely used in different types of tumours with high response rates, but it generally has low efficiency in melanoma. The mechanisms underpinning the phenomena are not sufficiently understood. Read More

    [Supratentorial Meningeal Melanoma with Nevus of Ota:A Case Report].
    No Shinkei Geka 2018 Feb;46(2):139-145
    Department of Neurosurgery, St. Luke's International Hospital.
    We present a rare case of supratentorial meningeal melanoma associated with ipsilateral nevus of Ota, and a review of the literature. The patient was a 32-year-old man with a right-sided nevus of Ota, presenting with unconsciousness. His CT and MRI scans revealed an extra axial tumor with dural tail signs; no lesion was detected on systemic examination. Read More

    Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis.
    Lancet Oncol 2018 Feb 12. Epub 2018 Feb 12.
    University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Background: Obesity has been linked to increased mortality in several cancer types; however, the relation between obesity and survival outcomes in metastatic melanoma is unknown. The aim of this study was to examine the association between body-mass index (BMI) and progression-free survival or overall survival in patients with metastatic melanoma who received targeted therapy, immunotherapy, or chemotherapy.

    Methods: This retrospective study analysed independent cohorts of patients with metastatic melanoma assigned to treatment with targeted therapy, immunotherapy, or chemotherapy in randomised clinical trials and one retrospective study of patients treated with immunotherapy. Read More

    Knockdown of MAGEA6 Activates AMP-Activated Protein Kinase (AMPK) Signaling to Inhibit Human Renal Cell Carcinoma Cells.
    Cell Physiol Biochem 2018 Feb 9;45(3):1205-1218. Epub 2018 Feb 9.
    Department of Urology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
    Background/aims: Melanoma antigen A6 (MAGEA6) is a cancer-specific ubiquitin ligase of AMP-activated protein kinase (AMPK). The current study tested MAGEA6 expression and potential function in renal cell carcinoma (RCC).

    Methods: MAGEA6 and AMPK expression in human RCC tissues and RCC cells were tested by Western blotting assay and qRT-PCR assay. Read More

    AIM2 regulates vascular smooth muscle cell migration in atherosclerosis.
    Biochem Biophys Res Commun 2018 Feb 12. Epub 2018 Feb 12.
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, No, 107 WenHuaXi Road, Jinan, Shandong, CN 250012, China. Electronic address:
    Background: Atherosclerosis (AS) is a common pathological basis of various cardiovascular and cerebrovascular diseases. Plaque formation is initiated and triggered by vascular smooth musclecells (VSMCs) migration in vascular wall, which gradually aggravates atherosclerosis progression. Absent in melanoma 2 (AIM2), a member of HIN-200 family, plays an important role in activating inflammasome. Read More

    Greater distance to an academic medical center is associated with poorer melanoma prognostic factors: The University of Colorado Experience.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    University of Colorado School of Medicine, Denver, Colorado.
    Introduction: Numerous studies report a correlation between distance to diagnostic provider in an academic medical center and poorer prognosis ofdisease. Limited research on this topic exists with respect to melanoma.

    Methods: This was a retrospective chart review of 1,463 adults (≥18 years) initially diagnosed with melanoma between 2006-2016. Read More

    Histological Immune Response Patterns in Sentinel Lymph Nodes Involved by Metastatic Melanoma and Prognostic Significance.
    J Cutan Pathol 2018 Feb 15. Epub 2018 Feb 15.
    Department of Pathology and Laboratory Medicine, University of Pennsylvania.
    Aims: To further characterize the micromorphometric immunological pattern to metastatic melanoma in SLN biopsies and completion lymph node (CLN) dissections and their relation to 5-year overall survival.

    Methods: Retrospective cohort of 49 patients from 1996 to 2005 with a positive SLN who underwent CLN dissection were studied. Micromorphometric characteristics included: follicular center count per profile (FCC), sinus histiocytosis, metastatic size, tumor infiltrating lymphocytes (intranodal), paracortial dendritic cells, germinal center reaction, and morphology. Read More

    Modulation of Tumor-Associated Macrophages (TAM) Phenotype by Platelet-Activating Factor (PAF) Receptor.
    J Immunol Res 2017 27;2017:5482768. Epub 2017 Dec 27.
    Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil.
    Platelet-activating factor (PAF) plays an important role in the pathogenesis of several types of tumors. The biological effects of PAF are mediated by the PAF receptor (PAFR), which can be expressed by tumor cells and host cells that infiltrate the tumor microenvironment. In the present study, we investigated the role of PAFR expressed by leukocytes that infiltrate two types of tumors, one that expresses PAFR (TC-1 carcinoma) and another that does not express the receptor (B16F10 melanoma) implanted in mice that express the receptor or not (PAFR KO). Read More

    The role of reflectance confocal microscopy in a case of Bowen's disease difficult to diagnose.
    Dermatol Pract Concept 2018 Jan 31;8(1):63-65. Epub 2018 Jan 31.
    Department of Dermatology, Faculty of Medicine, University of Ege, Izmir, Turkey.
    There have been limited reports describing reflectance confocal microscopy (RCM) features of Bowen's disease (BD). Herein, we describe the RCM features of a pigmented BD with atypical dermoscopic features, mimicking a melanoma. This case highlights the importance of RCM in a challenging BD. Read More

    Patient with confirmed LEOPARD syndrome developing multiple melanoma.
    Dermatol Pract Concept 2018 Jan 31;8(1):59-62. Epub 2018 Jan 31.
    Department of Dermatology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
    LEOPARD syndrome, also known as Gorlin syndrome II, cardiocutaneous syndrome, lentiginosis profusa syndrome, Moynahan syndrome, was more recently coined as Noonan syndrome with multiple lentigines (NSML), inside the RASopathies. Historically, the acronym LEOPARD refers to the presence of distinctive clinical features such as: lentigines (L), electrocardiographic/conduction abnormalities (E), ocular hypertelorism (O), pulmonary stenosis (P), genital abnormalities (A), retardation of growth (R), and sensorineural deafness (D). This condition is identified in 85% of patients with phenotype hallmarks caused by presence a germline point mutation in PTPN11 gene. Read More

    Immunotherapy for Metastatic Melanoma with Right Atrial Involvement in a Patient with Rheumatoid Arthritis.
    Case Rep Oncol Med 2017 28;2017:8095601. Epub 2017 Dec 28.
    Virginia Commonwealth University, 1250 E. Marshall Street, Richmond, VA 23219, USA.
    Prognosis for metastatic melanoma has improved significantly with the use of immune checkpoint inhibitors. Given improvements in survival, aggressive surgical treatment may be considered in patients with life-threatening complications from their disease that would not otherwise be considered in advanced disease. Patients with preexisting autoimmune diseases or prior immune-related adverse events from therapy are largely excluded from clinical trials. Read More

    Widespread finger skin metastases of melanoma.
    Clin Case Rep 2018 Feb 15;6(2):448-449. Epub 2018 Jan 15.
    Institute of OncologyUniversity of IstanbulIstanbulTurkey.
    Metastatic melanoma is a fatal disease with a rapid systemic dissemination. Almost every organ might be affected, but lungs, liver, bone, brain, and skin are the most frequently involved sites. Intravascular microtumoral embolism is believed to account for the distant cutaneous metastases that might be the first manifestation of disease progression in most of the cases. Read More

    New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy.
    Biologics 2018 9;12:43-60. Epub 2018 Feb 9.
    PanTherapeutics, Lutry, Switzerland.
    Oncolytic viruses have demonstrated selective replication and killing of tumor cells. Different types of oncolytic viruses - adenoviruses, alphaviruses, herpes simplex viruses, Newcastle disease viruses, rhabdoviruses, Coxsackie viruses, and vaccinia viruses - have been applied as either naturally occurring or engineered vectors. Numerous studies in animal-tumor models have demonstrated substantial tumor regression and prolonged survival rates. Read More

    ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity.
    Nat Commun 2018 Feb 14;9(1):676. Epub 2018 Feb 14.
    Humanitas Clinical and Research Center, via Manzoni 56, 20089, Rozzano, MI, Italy.
    Atypical chemokine receptors (ACKRs) are regulators of leukocyte traffic, inflammation, and immunity. ACKR2 is a scavenger for most inflammatory CC chemokines and is a negative regulator of inflammation. Here we report that ACKR2 is expressed in hematopoietic precursors and downregulated during myeloid differentiation. Read More

    Modulation of pro-apoptotic effects and mitochondrial potential on B16F10 cells by DODAC/PHO-S liposomes.
    BMC Res Notes 2018 Feb 14;11(1):126. Epub 2018 Feb 14.
    Biochemistry and Biophysical Laboratory, Butantan Institute, 1500, Vital Brasil Avenue, Sao Paulo, 05503-900, Brazil.
    Objective: We aimed to evaluate the potential of DODAC/PHO-S liposomes on the modulation of the expression of pro-apoptotic proteins, loss of lysosomal integrity and the mitochondrial electrical potential, compared with phosphoethanolamine.

    Results: The results of this study demonstrate that DODAC/PHO-S liposomes have exhibited broad cytotoxic potential in B16F10 murine melanoma cells, with significantly greater proportions than treatment with PHO-S. The treatment with the DODAC/PHO-S 2. Read More

    Optimization of resources by drug management: A multicentred web-administered study on the use of ipilimumab in Italy.
    J Oncol Pharm Pract 2018 Jan 1:1078155218755867. Epub 2018 Jan 1.
    7 Pharmacy, 90383 Istituto Oncologico Veneto Istituto di Ricovero e Cura a Carattere Scientifico , Padova, Veneto, Italy.
    Objective In a scenario of new expensive cancer therapies entering the market, strategies of optimisation and cost containment are crucial in oncology care. Better management of drug waste and centralization of drug preparation can be effective strategies to achieve these goals. The aim of this work is to describe the economic management of a high cost anticancer drug (ipilimumab) in some Italian reference centres. Read More

    Acute autoimmune myocarditis and hepatitis due to ipilimumab monotherapy for malignant melanoma.
    J Oncol Pharm Pract 2018 Jan 1:1078155218755868. Epub 2018 Jan 1.
    3 Lucy Curci Cancer Center, Eisenhower Medical Center, Rancho Mirage, CA, USA.
    An important agent in melanoma therapy, ipilimumab is associated with autoimmune toxicity. Two cases of autoimmune pericarditis and large pericardial effusion have been documented with its use. Reports of myocardial toxicity have surfaced with this agent, mainly when used in combination with PD1 blockade. Read More

    Retina 2018 Feb 13. Epub 2018 Feb 13.
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
    Purpose: To evaluate the natural history of myelinated retinal nerve fiber layer (MRNFL) through clinical features and enhanced depth imaging optical coherence tomography.

    Methods: This is a retrospective, noncomparative, case series of patients who underwent thorough clinical examination to document associated ocular and systemic features. Enhanced depth imaging optical coherence tomography was performed when MRNFL was located posteriorly and accessible to imaging. Read More

    Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis.
    Medicine (Baltimore) 2018 Feb;97(7):e9738
    Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Union Medical Center.
    One of the most common head and neck cancers is laryngeal squamous cell carcinoma (LSCC). LSCC exhibits high mortality rates and has a poor prognosis. The molecular mechanisms leading to the development and progression of LSCC are not entirely clear despite genetic and therapeutic advances and increased survival rates. Read More

    IL-2 and Beyond in Cancer Immunotherapy.
    J Interferon Cytokine Res 2018 Feb;38(2):45-68
    2 Department of Surgery, Medical University of South Carolina , Charleston, South Carolina.
    The development of the T- and natural killer (NK) cell growth factor IL-2 has been a sentinel force ushering in the era of immunotherapy in cancer. With the advent of clinical grade recombinant IL-2 in the mid-1980s, oncologists could for the first time directly manipulate lymphocyte populations with systemic therapy. By itself, recombinant IL-2 can induce clinical responses in up to 15% of patients with metastatic cancer or renal cell carcinoma. Read More

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