134,334 results match your criteria Malignant Melanoma


BRAF inhibition in melanoma is associated with the dysregulation of histone methylation and histone methyltransferases.

Neoplasia 2020 Jul 3;22(9):376-389. Epub 2020 Jul 3.

The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA; Masonic Cancer Center, 2231 6th St SE, Minneapolis, MN 5545, USA. Electronic address:

The development of mutant BRAF inhibitors has improved the outcome for melanoma patients with BRAF mutations. Although the initial response to these inhibitors can be dramatic, sometimes resulting in complete tumor regression, the majority of melanomas become resistant. To study resistance to BRAF inhibition, we developed a novel mouse model of melanoma using a tetracycline/doxycycline-regulated system that permits control of mutant BRAF expression. Read More

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http://dx.doi.org/10.1016/j.neo.2020.06.006DOI Listing

ASSOCIATION OF INITIAL VIRAL LOAD IN SARS-CoV-2 PATIENTS WITH OUTCOME AND SYMPTOMS.

Am J Pathol 2020 Jul 3. Epub 2020 Jul 3.

Department of Pathology, NYU Langone Health, New York City, NY; Department of Dermatology, NYU Langone Health, New York City, NY. Electronic address:

The dynamics of viral load (VL) of the 2019 novel coronavirus (SARS-CoV-2) and its association with different clinical parameters remain poorly characterized in the United States patient population. Herein we investigate associations between VL and parameters such as severity of symptoms, disposition (admission vs direct discharge), length of hospitalization, and admission to the intensive care unit, length of need for oxygen support and overall survival in a cohort of 205 patients from a tertiary care center in New York City. VL was determined using q-PCR and Log10 transformed for normalization. Read More

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http://dx.doi.org/10.1016/j.ajpath.2020.07.001DOI Listing

Staging 18F-FDG PET/CT influences the treatment plan in melanoma patients with satellite or in-transit metastases.

Melanoma Res 2020 Aug;30(4):358-363

aMelanoma Institute Australia, Sydney, Australia bDepartment of Surgical Oncology, University Medical Center Groningen, University of Groningen, the Netherlands cDepartment of Radiology, Mater Hospital dFaculty of Medicine and Health, The University of Sydney, Sydney eDepartment of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital Camperdown, Camperdown fDepartment of Nuclear Medicine and PET, St Vincent's Hospital, Sydney, Australia.

Whole-body positron emission tomography/computed tomography (PET/CT) and brain magnetic resonance imaging (MRI) are commonly used to stage patients with palpable lymph node metastases from melanoma, but their role in patients with satellite and/or in-transit metastasis (S&ITM) is unclear. The aim of this study was to establish the diagnostic value of PET/CT and brain MRI in these patients, and to assess their influence on subsequent management decisions. In this prospective study, 25 melanoma patients with a first presentation of S&ITM who had no clinical evidence of palpable nodal or distant metastasis underwent whole-body F-FDG PET/CT and brain MRI after a tentative pre-scan treatment plan had been made. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000666DOI Listing

Intracellular signaling modules linking DNA damage to secretome changes in senescent melanoma cells.

Melanoma Res 2020 Aug;30(4):336-347

aCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA bÉcole Polytechnique Universitaire Polytech'Nice-Sophia, Sophia Antipolis, France.

Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanocyte and melanoma cell senescence is likely to come into play as a key factor affecting the course of tumorigenesis and responsiveness to therapy; little mechanistic information has been generated, however, that substantiates this idea and facilitates its clinical translation. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000671DOI Listing

Recent developments in head and neck melanoma.

Curr Opin Otolaryngol Head Neck Surg 2020 Aug;28(4):258-262

Department of Otolaryngology, Head and Neck Surgery, SUNY Upstate Medical University, Syracuse, New York, USA.

Purpose Of Review: To provide an overview of recently published articles covering melanoma management of the head and neck region.

Recent Findings: Melanoma management represents a rapidly evolving field. The advent of immunotherapy has led to significant changes in diagnosis, treatment, and surveillance for these patients. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000633DOI Listing

Fasten the seat belt: Increasing safety of CAR T-cell therapy.

Exp Dermatol 2020 Jul 5. Epub 2020 Jul 5.

Department of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany.

After the recent success and approvals of chimeric antigen receptor (CAR) T cells in haematological malignancies, its efficacy is currently evaluated in a broad spectrum of tumor entities including melanoma. However, severe and potentially life-threatening side effects like cytokine release syndrome, neurologic toxicities, and the competing risk of morbidity and mortality from the treatment itself are still a major limiting factor in the current CAR T-cell landscape. In addition, especially in solid tumors, the lack of ideal target antigens to avoid on-target/off-tumor toxicities also restricts its use. Read More

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http://dx.doi.org/10.1111/exd.14131DOI Listing

Mechanistic insight of predictive biomarkers for antitumor PD‑1/PD‑L1 blockade: A paradigm shift towards immunome evaluation (Review).

Oncol Rep 2020 Aug 11;44(2):424-437. Epub 2020 Jun 11.

Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, P.R. China.

Checkpoint inhibitor‑based immunotherapy has exhibited unprecedented success in the treatment of advanced‑stage cancer in recent years. Several therapeutic antibodies targeting programmed death‑1 (PD‑1) or its ligand (PD‑L1) have received regulatory approvals for the treatment of multiple malignancies, including melanoma, non‑small cell lung cancer, kidney cancer and Hodgkin's lymphoma. However, a substantial proportion of patients still do not benefit from these agents, let alone the risk of immune‑associated toxicities and financial burden. Read More

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http://dx.doi.org/10.3892/or.2020.7643DOI Listing

Chitosan-Based Delivery of Avian Reovirus Fusogenic Protein p10 Gene: and Studies towards a New Vaccine against Melanoma.

Biomed Res Int 2020 13;2020:4045760. Epub 2020 Jun 13.

Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, USACH, Alameda, 3363 Santiago, Chile.

Reovirus is known to have an anticancer effect in both the preclinical and clinical assays. Current evidence suggests that the reovirus-mediated impact on tumor growth depends on the activation of specific antitumor immune responses. A feasible explanation for the oncolytic effects and immune system activation is through the expression of the fusogenic reovirus protein. Read More

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http://dx.doi.org/10.1155/2020/4045760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306838PMC

Histone Deacetylase Inhibitors to Overcome Resistance to Targeted and Immuno Therapy in Metastatic Melanoma.

Front Cell Dev Biol 2020 17;8:486. Epub 2020 Jun 17.

Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chunchon, South Korea.

Therapies that target oncogenes and immune checkpoint molecules constitute a major group of treatments for metastatic melanoma. A mutation in (BRAF V600E) affects various signaling pathways, including mitogen activated protein kinase (MAPK) and PI3K/AKT/mammalian target of rapamycin (mTOR) in melanoma. Target-specific agents, such as MAPK inhibitors improve progression-free survival. Read More

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http://dx.doi.org/10.3389/fcell.2020.00486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311641PMC

Interval between planning and frameless stereotactic radiosurgery for brain metastases: are our margins still accurate?

Neurooncol Pract 2020 Mar 1;7(2):211-217. Epub 2019 Oct 1.

CHU-Bordeaux, Radiotherapy Department, France.

Background: Advances in intracranial stereotactic radiosurgery (SRS) have led to dramatically reduced planning target volume (PTV) margins. However, tumor growth between planning and treatment may lead to treatment failure. Our purpose was to assess the kinetics of tumor growth before SRS for brain metastases. Read More

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http://dx.doi.org/10.1093/nop/npz048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318853PMC

An embedded novel compact feature profile image in speech signal for teledermoscopy system.

Health Inf Sci Syst 2020 Dec 25;8(1):23. Epub 2020 Jun 25.

Department of Electronics and Electrical Communications Engineering, Faculty of Engineering, Tanta University, Tanta, Egypt.

Background And Objectives: Teledermoscopy is a promising telemedicine service for remote diagnosis and treatment of skin diseases using dermoscopy images. It requires high quality transmission services, efficient utilization of channel bandwidth, effective storage, and security. Thus, this work develops an improved teledermoscopy system that guarantees the efficient and secure transmission of the dermoscopy images. Read More

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http://dx.doi.org/10.1007/s13755-020-00113-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316950PMC
December 2020

Boosting the Synthesis of Pharmaceutically Active Abietane Diterpenes in Hairy Roots by Engineering the and Genes.

Front Plant Sci 2020 18;11:924. Epub 2020 Jun 18.

Department of Pharmacy, University of Salerno, Fisciano, Italy.

Abietane diterpenoids (ADs), synthesized in the roots of different species, such as aethiopinone, 1-oxoaethiopinone, salvipisone, and ferruginol, have a variety of known biological activities. We have shown that aethiopinone has promising cytotoxic activity against several human tumor cell lines, including the breast adenocarcinoma MCF7, HeLa, epithelial carcinoma, prostate adenocarcinoma PC3, and human melanoma A375. The low content of these compounds in natural sources, and the limited possibility to synthesize them chemically at low cost, prompted us to optimize the production of abietane diterpenoids by targeting genes of the methylerythritol phosphate (MEP) pathway, from which they are derived. Read More

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http://dx.doi.org/10.3389/fpls.2020.00924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315395PMC

Synthesis and Biological Evaluation of the Anti-Melanogenesis Effect of Coumaric and Caffeic Acid-Conjugated Peptides in Human Melanocytes.

Front Pharmacol 2020 17;11:922. Epub 2020 Jun 17.

Department of Medical Laboratory Science, College of Health Science, Dankook University, Cheonan, South Korea.

Excessive pigmentation and reduced elasticity are the major skin problems that dermatologists and cosmetologists address. Compounds that inhibit melanin production might contribute to improving skin problems. In this study, we investigated whether coumaric acid- and caffeic acid-conjugated peptides might affect alpha-melanocyte stimulating hormone-induced melanin production, tyrosinase activity, and melanin synthesis-related gene expression in SK-MEL-2 human melanoma cells. Read More

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http://dx.doi.org/10.3389/fphar.2020.00922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311773PMC

[Understanding and therapeutic targeting of aberrant mRNA splicing mechanisms in oncogenesis].

Rinsho Ketsueki 2020 ;61(6):643-650

Department of Hematology-Oncology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe.

Splicing factor 3b subunit 1 (SF3B1) is the most commonly mutated RNA splicing factor identified in myelodysplastic syndrome (MDS), chronic lymphocytic leukemia, and uveal melanoma. The mechanisms by which SF3B1 mutations promote malignancy are poorly understood. Here, we integrated pan-cancer RNA sequencing to identify mutant SF3B1-dependent aberrant splicing events with a positive CRISPR screen to prioritize alterations that functionally promote oncogenesis. Read More

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http://dx.doi.org/10.11406/rinketsu.61.643DOI Listing
January 2020

Immunotherapy in sinonasal melanoma: treatment patterns and outcomes compared to cutaneous melanoma.

Int Forum Allergy Rhinol 2020 Jul 5. Epub 2020 Jul 5.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, La Jolla, CA.

Background: Although treatment with checkpoint blockade is now accepted as standard of care for cutaneous melanoma, few studies have investigated its role in sinonasal melanoma (SNM). We aimed to evaluate whether immunotherapy was associated with improved survival in SNM and to compare the effect of immunotherapy in metastatic sinonasal and cutaneous melanoma.

Methods: This was a cohort study of patients included in the United States National Cancer Database who had been diagnosed with sinonasal or cutaneous melanoma between 2012 and 2015 and had complete information regarding immunotherapy status. Read More

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http://dx.doi.org/10.1002/alr.22628DOI Listing

Establishment of a Mouse Model for Post-Inflammatory Hyperpigmentation.

Pigment Cell Melanoma Res 2020 Jul 4. Epub 2020 Jul 4.

Department of Dermatology, Yamagata University, Faculty of Medicine, Yamagata, Japan.

Post-inflammatory hyperpigmentation (PIH) is a common cutaneous condition that can cause a disfigured appearance. However, the pathophysiology of PIH remains poorly understood, at least in part, because an appropriate animal model for research has not been established. In order to analyze the pathomechanism of PIH, we successfully induced PIH in a hairless version of transgenic mice (hk14-SCF Tg/HRM) that have a human-type epidermis containing melanin by repeated hapten application of 2,4-dinitrofluorobenzene. Read More

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http://dx.doi.org/10.1111/pcmr.12911DOI Listing

Effectiveness of a stop smoking service in reducing cigarette smoking in patients referred from an NHS dermatology centre.

Br J Dermatol 2020 Jul 4. Epub 2020 Jul 4.

Department of Dermatology, University Hospital of Wales, Cardiff, UK.

Cigarette smoking is the leading avoidable cause of mortality in the UK. Individuals who start smoking in early adult life lose 10 years of life expectancy. Smoking is a risk factor for psoriasis [odds ratio (OR) of 1. Read More

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http://dx.doi.org/10.1111/bjd.19378DOI Listing

The MelFo Study UK: Effects of a Reduced-Frequency, Stage-Adjusted Follow-Up Schedule for Cutaneous Melanoma 1B to 2C Patients After 3-Years.

Ann Surg Oncol 2020 Jul 4. Epub 2020 Jul 4.

Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Evidence-based guidelines for follow-up treatment of American Joint Committee on Cancer (AJCC) stages 1B to 2C melanoma patients are lacking. The MELanoma FOllow-up study is an international phase 3 randomized trial, and the 3-year interim data were recently reported from the Netherlands. The study was undertaken concurrently with a British cohort for comparison and validation of the Dutch study. Read More

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http://dx.doi.org/10.1245/s10434-020-08758-2DOI Listing

A multidisciplinary consensus on the morphological and functional responses to immunotherapy treatment.

Clin Transl Oncol 2020 Jul 4. Epub 2020 Jul 4.

Radiology Department, Ramón y Cajal University Hospital, Madrid, Spain.

The implementation of immunotherapy has radically changed the treatment of oncological patients. Currently, immunotherapy is indicated in the treatment of patients with head and neck tumors, melanoma, lung cancer, bladder tumors, colon cancer, cervical cancer, breast cancer, Merkel cell carcinoma, liver cancer, leukemia and lymphomas. However, its efficacy is restricted to a limited number of cases. Read More

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http://dx.doi.org/10.1007/s12094-020-02442-3DOI Listing

Acceptability of online sun exposure awareness-raising interventions among young Australian women: an exploratory mixed-methods study.

Health Promot Int 2020 Jul 5. Epub 2020 Jul 5.

Flinders Centre for Innovation in Cancer, College of Medicine and Public Health, Flinders University of South Australia, GPO Box 2100, Adelaide, South Australia 5001, Australia.

Melanoma is the most common cancer among young Australians. Despite school-based programs such as 'Sun Smart' leading to increased knowledge among children of the harmful effects of sun exposure, many young adults continue to desire a darker skin tone because of a general perception among their peers that tanned skin is attractive. This 'tanned-ideal' may be challenged through exposure to material posted on social media. Read More

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http://dx.doi.org/10.1093/heapro/daaa048DOI Listing

Immune checkpoint inhibitors: Key trials and an emerging role in breast cancer.

Semin Cancer Biol 2020 Jul 2. Epub 2020 Jul 2.

National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland. Electronic address:

This review focuses on immune checkpoint inhibitors - immunomodulatory agents that aim to relieve tumour-mediated immune-cell suppression. Immune checkpoint proteins can be expressed on the tumour-cell or immune-cell populations. Immune checkpoint proteins dampen the immune response by inactivating immune cells capable of tumour destruction. Read More

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http://dx.doi.org/10.1016/j.semcancer.2020.06.016DOI Listing

PD-1 Blockade in Japanese Patients with Acral Lentiginous Melanoma.

Authors:
A N Shoushtari

Ann Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Medicine, Melanoma and Immunotherapeutics Service, Memorial Sloan Kettering Cancer Center, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.annonc.2020.06.014DOI Listing

From putative brain tumor marker to high cognitive abilities: emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain.

J Chem Neuroanat 2020 Jul 2:101846. Epub 2020 Jul 2.

Department of Psychiatry, Otto-von-Guericke University, Magdeburg, Germany.

ADAM (a disintergin and metalloprotease) 12 is a member of the large family of multidomain metalloprotease-disintegrins, which possess cell-binding and metalloprotease properties. The enzyme is responsible for the shedding of a number of membrane-bound proteins (heparin-binding-EGF, insulin-like growth factor 2-binding proteins 3 and 5, oxytocinase, glycoprotein non-metastatic melanoma protein B and basigin). In rat and human CNS, ADAM12 is predominantly localized in white and gray matter oligodendrocytes. Read More

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http://dx.doi.org/10.1016/j.jchemneu.2020.101846DOI Listing

ICG-loaded gold nano-bipyramids with NIR activatable dual PTT-PDT therapeutic potential in melanoma cells.

Colloids Surf B Biointerfaces 2020 Jun 26;194:111213. Epub 2020 Jun 26.

Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, Treboniu Laurean No.42, Cluj-Napoca 400271, Romania; Biomolecular Physics Department, Faculty of Physics, Babes-Bolyai University, M Kogalniceanu No. 1, Cluj-Napoca 400084, Romania. Electronic address:

A great amount of effort is directed towards the progress of cancer treatment approaches aspiring to develop non-invasive, targeted and highly efficient therapies. In this context, Photothermal (PTT) and Photodynamic (PDT) Therapies were proven as promising. This work aims to integrate the therapeutic activities of two near-infrared (NIR) photoactive biomaterials - gold nano-bipyramids (AuBPs) and Indocyanine Green (ICG) - into one single targeted hybrid nanosystem able to operate as dual PTT-PDT agent with higher efficiency compared with each one alone. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111213DOI Listing

A Retrospective Multicenter Study of Fatal Pediatric Melanoma.

J Am Acad Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Memorial Sloan Kettering Skin Cancer Center, Dermatology Service, Department of Medicine, New York, New York 10022, USA.

Background: Pediatric melanoma is rare and diagnostically challenging.

Objective: Characterize clinical and histopathological features of fatal pediatric melanomas.

Methods: Multi-center retrospective study of fatal melanoma cases in patients under 20 years diagnosed between 1994-2017. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.06.1010DOI Listing

Extensive "stalagmite" epi-iridic juvenile xanthogranuloma simulating diffuse melanoma in a 16-year-old girl.

J AAPOS 2020 Jul 1. Epub 2020 Jul 1.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania;. Electronic address:

A 16-year-old girl noted worsening redness and photophobia of the right eye that had previously been treated unsuccessfully with sequential courses of topical antibiotics and topical corticosteroids. Clinical examination revealed diffuse flakelike thickening of the iris surface, pupillary margin, and anterior chamber angle, suggesting diffuse iris melanoma. Anterior segment optical coherence tomography depicted the mass as an epi-iridic deposit with "stalagmite" surface appearance. Read More

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http://dx.doi.org/10.1016/j.jaapos.2020.04.001DOI Listing

In vivo effects of the association of the psychoactive phenotiazine thioridazine on antitumor activity and hind limb paralysis induced by the native polypeptide crotamine.

Toxicon 2020 Jul 1. Epub 2020 Jul 1.

Departamento de Farmacologia, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), SP, Brazil. Electronic address:

Crotamine is a cationic polypeptide composed by 42 amino acid residues with several pharmacological and biological properties, including the selective ability to enter and kill actively proliferating tumour cells, which led us to propose its use as a theranostic agent for cancer therapy. At the moment, the improvement of crotamine antitumoral efficacy by association with chemotherapeutic adjuvants is envisioned. In the present work, we evaluated the association of crotamine with the antitumoral adjuvant phenotiazine thioridazine (THD). Read More

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http://dx.doi.org/10.1016/j.toxicon.2020.06.017DOI Listing

CRISPR/Cas9-mediated Knockout of SIRT6 Imparts Remarkable Anti-proliferative Response in Human Melanoma Cells in vitro and in vivo.

Photochem Photobiol 2020 Jul 4. Epub 2020 Jul 4.

Department of Dermatology, University of Wisconsin, 436 MSC, 1300 University Avenue, Madison, Wisconsin, 53705, USA.

Melanoma is one of the most aggressive, potentially fatal forms of skin cancer, and has been shown to be associated with solar ultraviolet radiation-dependent initiation and progression. Despite remarkable recent advances with targeted- and immune- therapeutics, lasting and recurrence-free survival remain significant concerns. Therefore, additional novel mechanism-based approaches are needed for effective melanoma management. Read More

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http://dx.doi.org/10.1111/php.13305DOI Listing

Amelanotic melanoma in a patient with oculocutaneous albinism.

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Department of Dermatology, Hospital Clinico Universitario de Valladolid, Valladolid.

Oculocutaneous albinism is a genetically heterogeneous, autosomal recessive group of disorders characterized by a generalized decreased or absence of melanin pigment in the eyes, hair, and skin. These patients have a greater sensitivity to UV radiation and a predisposition to skin tumors, mainly squamous cell carcinoma and basal cell carcinomas, and to a lesser extent malignant melanomas. Melanoma can be one of the most challenging cancers to diagnose in patients with albinism. Read More

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Mohs micrographic surgery: a treatment method for many non-melanocytic skin cancers.

Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

Department of Dermatology, Baylor College of Medicine, Houston, TX.

Mohs micrographic surgery (MMS) is a breakthrough surgical technique that has changed the management of neoplasms in dermatology. Through continued practice and evolution, MMS now can successfully treat a variety of rare non-melanocytic cutaneous malignancies for which achieving remission and the optimal aesthetic result after surgery was previously challenging. Mohs micrographic surgery has utility for conditions besides melanoma. Read More

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Geometric regulation of histone state directs melanoma reprogramming.

Commun Biol 2020 Jul 3;3(1):341. Epub 2020 Jul 3.

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Malignant melanoma displays a high degree of cellular plasticity during disease progression. Signals in the tumor microenvironment are believed to influence melanoma plasticity through changes in the epigenetic state to guide dynamic differentiation and de-differentiation. Here we uncover a relationship between geometric features at perimeter regions of melanoma aggregates, and reprogramming to a stem cell-like state through histone marks H3K4Me2 and H3K9Ac. Read More

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http://dx.doi.org/10.1038/s42003-020-1067-1DOI Listing

Proteome analysis revealed the essential functions of protein phosphatase PP2A in the induction of Th9 cells.

Sci Rep 2020 Jul 3;10(1):10992. Epub 2020 Jul 3.

Immuno-Biology Laboratory, Translational Health Science and Technology Institute (THSTI), 3rd Milestone Gurgaon-Faridabad Expressway, Faridabad, Haryana, 121 001, India.

Proteomic analysis identifies post-translational functions of proteins, which remains obscure in transcriptomics. Given the important functions of Th9 cells in anti-tumor immunity, we performed proteome analysis of Th9 cells to understand the involvement of proteins that might be crucial for the anti-tumor functions of Th9 cells. Here we performed a comprehensive proteomic analysis of murine Th0 and Th9 cells, and identified proteins that are enriched in Th9 cells. Read More

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http://dx.doi.org/10.1038/s41598-020-67845-2DOI Listing

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.

Nat Commun 2020 Jul 3;11(1):3353. Epub 2020 Jul 3.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree of polygenicity, involving at a minimum of thousands of loci. Read More

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http://dx.doi.org/10.1038/s41467-020-16483-3DOI Listing

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth.

Nat Commun 2020 Jul 3;11(1):3326. Epub 2020 Jul 3.

Department of Molecular Biology and Biochemistry; School of Biological Sciences, University of California, Irvine, Irvine, CA, 92697, USA.

Tumour cells adapt to nutrient deprivation in vivo, yet strategies targeting the nutrient poor microenvironment remain unexplored. In melanoma, tumour cells often experience low glutamine levels, which promote cell dedifferentiation. Here, we show that dietary glutamine supplementation significantly inhibits melanoma tumour growth, prolongs survival in a transgenic melanoma mouse model, and increases sensitivity to a BRAF inhibitor. Read More

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http://dx.doi.org/10.1038/s41467-020-17181-wDOI Listing

Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas.

Anticancer Res 2020 Jul;40(7):4017-4022

Department of Translational Medical Sciences, University of Campania "L. Vanvitelli", Naples, Italy

Background/aim: Squamous cell carcinoma (SCC) is highly prevalent in kidney transplant patients (KT). It is characterized by the presence of an inflammatory infiltrate. In this study, we examined the presence of similar infiltrates in intact skin, which could be regarded as a precancerous step. Read More

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http://dx.doi.org/10.21873/anticanres.14396DOI Listing

Novel Prognostic Factor for Uveal Melanoma: Bioinformatics Analysis of Three Independent Cohorts.

Anticancer Res 2020 Jul;40(7):3839-3846

Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea

Background/aim: Because 50% of uveal melanoma metastasize within 10 years of diagnosis, there is urgent need for accurate prognostic factors.

Materials And Methods: To identify genes that can act as prognostic factors in uveal melanoma, we performed survival analyses using three independent cohorts. Using log-rank test and univariate cox regression, genes which could stratify the prognosis in all cohorts simultaneously depending on their expression levels were selected as novel biomarkers. Read More

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http://dx.doi.org/10.21873/anticanres.14373DOI Listing

BNIP3L Is a New Autophagy Related Prognostic Biomarker for Melanoma Patients Treated With AGI-101H.

Anticancer Res 2020 Jul;40(7):3723-3732

Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland.

Background/aim: Skin melanoma belongs to the most invasive malignancies with no cure for a progressing disease. Personalized therapy would allow for the selection of patients that will benefit from treatment. For this purpose, proper predictive biomarkers must be defined. Read More

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http://dx.doi.org/10.21873/anticanres.14361DOI Listing

British Gynaecological Cancer Society (BGCS) vulval cancer guidelines: Recommendations for practice.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 8. Epub 2020 Jun 8.

Gynaecologic Oncology, Imperial College London Faculty of Medicine, London, SW7 2DD, UK.

The purpose of this guideline is to collate evidence and propose evidence-based guidelines for the diagnosis and management of adult patients with vulva carcinoma treated in the UK. Malignant melanoma may present via similar routes and will be discussed. The reader is referred to the Ano-uro-genital Mucosal Melanoma Full Guideline [1] for more detailed recommendations. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.054DOI Listing

Conjunctival melanoma: Opportune detection and resolution of a fast-growing conjunctival lesion.

J Fr Ophtalmol 2020 Jun 30. Epub 2020 Jun 30.

Asociación para Evitar la Ceguera en México, Hospital "Dr. Luis Sánchez Bulnes", 46, Vicente Garcia Torres, 04030 Mexico City, Mexico.

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http://dx.doi.org/10.1016/j.jfo.2020.01.005DOI Listing

Dedifferentiated melanomas: Morpho-phenotypic profile, genetic reprogramming and clinical implications.

Cancer Treat Rev 2020 Jun 23;88:102060. Epub 2020 Jun 23.

Unit of Melanoma, Division of Medical Oncology, Department of Oncology and Haematology, Papa Giovanni XXIII Cancer Center Hospital, Bergamo, Italy. Electronic address:

Phenotypic plasticity of malignant melanoma is a well-known phenomenon. Several translational studies and small case series have reported this clinical and biological entity, particularly in metastatic melanoma, showing frequent aberrant expression of non-melanocytic differentiation markers of different lineages, posing remarkable challenges due to several alternative differential diagnoses including undifferentiated carcinoma and sarcomas. When melanoma loses its typical morpho-phenotype by routinely used diagnostic immunohistochemical markers, it is defined as "dedifferentiated melanoma". Read More

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http://dx.doi.org/10.1016/j.ctrv.2020.102060DOI Listing

Peripheral cytokines are not influenced by the type of surgical approach for non-small cell lung cancer by four weeks postoperatively.

Lung Cancer 2020 Jun 27;146:303-309. Epub 2020 Jun 27.

Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, United States. Electronic address:

Objectives: The influence of surgical approach on systemic inflammatory response and the subsequent oncologic impact for non-small cell lung cancer is debated. We aimed to measure the effects of thoracic surgical approach on peripheral cytokine milieu over time.

Methods: Patients undergoing primary lung resection without neoadjuvant therapy (2016-2018) were evaluated. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.06.022DOI Listing

Phenformin promotes keratinocyte differentiation via the calcineurin/NFAT pathway.

J Invest Dermatol 2020 Jun 30. Epub 2020 Jun 30.

Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China; Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Phenformin is a drug in the biguanide class that was previously used to treat type 2 diabetes. We have reported the anti-tumor activities of phenformin to enhance the efficacy of BRAF-MEK-ERK pathway inhibition and to inhibit myeloid-derived suppressor cells in various melanoma models. Here we demonstrate that phenformin suppresses tumor growth and promotes keratinocyte differentiation in the DMBA/TPA two stage skin carcinogenesis mouse model. Read More

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http://dx.doi.org/10.1016/j.jid.2020.05.114DOI Listing

Recent developments in head and neck melanoma.

Curr Opin Otolaryngol Head Neck Surg 2020 Jun 28. Epub 2020 Jun 28.

Department of Otolaryngology, Head and Neck Surgery, SUNY Upstate Medical University, Syracuse, New York, USA.

Purpose Of Review: To provide an overview of recently published articles covering melanoma management of the head and neck region.

Recent Findings: Melanoma management represents a rapidly evolving field. The advent of immunotherapy has led to significant changes in diagnosis, treatment, and surveillance for these patients. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000633DOI Listing

Immune Checkpoint Inhibitor Therapy as an Eye-Preserving Treatment for Locally Advanced Conjunctival Melanoma.

Ophthalmic Plast Reconstr Surg 2020 Jun 17. Epub 2020 Jun 17.

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston.

The authors present 2 patients with locally advanced conjunctival melanoma for whom definitive surgery would mean an orbital exenteration with its associated inherent total visual loss and major facial disfigurement. Instead both patients were treated with immune checkpoint inhibitor therapy. In 1 patient neoadjuvant pembrolizumab was used for approximately 12 months and the patient experienced near-total clinical resolution of the conjunctival melanoma. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001700DOI Listing

Ultrasound findings of proliferative nodule arising in a congenital melanocytic nevus.

Melanoma Res 2020 Jun 26. Epub 2020 Jun 26.

Department of Dermatology, Melanoma Unit, Hospital Clinic, IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain.

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http://dx.doi.org/10.1097/CMR.0000000000000565DOI Listing

Trends in pediatric skin cancer.

Curr Opin Pediatr 2020 Jun 30. Epub 2020 Jun 30.

Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: To inform pediatric providers of the clinical characteristics, underlying genetic drivers, and therapeutic options for skin cancer arising in childhood and adolescence.

Recent Findings: The incidence of melanoma in pediatric patients has been declining in the past decades. Pediatric-specific diagnostic criteria should be utilized when assessing lesions concerning for melanoma to better account for the different presentations seen in pediatric disease compared with adults, such as an increased prevalence of amelanotic melanoma or frequent mimic of benign pediatric lesions. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000917DOI Listing

Early Phase of Primary Melanoma Growth from the Patient Point of view: A Prospective Cross Sectional Study on Melanoma over 1 mm in Thickness.

Acta Derm Venereol 2020 Jul 3. Epub 2020 Jul 3.

Department of Dermatology and Skin Cancer, CHU Timone, APHM, Aix Marseille University, INSERM, CRCM, FR-13885 Marseille, France.

A Nodular Pink Lesion with an Uncommon Diagnosis: A QuizMost melanomas are diagnosed by the patients themselves or by their partners or relatives; they alone can describe its history. We designed a prospective cross-sectional study to describe patients' perception of morphology, growth pattern and kinetics of their primary melanoma over 1 mm in thickness before resection. Patients were interviewed with a questionnaire, a grid representing 9 possible scenarios of melanoma growth, and a set of 87 photographs of potential aspects of melanomas and precursors. Read More

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http://dx.doi.org/10.2340/00015555-3591DOI Listing

Vascular Endothelial Growth Factor Receptor-3 Expression Predicts Sentinel Node Status in Primary Cutaneous Melanoma.

Acta Derm Venereol 2020 Jul 3. Epub 2020 Jul 3.

Department of Dermatology, University Medical Center, Ruprecht-Karls-University Heidelberg, DE-69120 Heidelberg, Germany. E-mail:

This study analysed the expression of vascular endothelial growth factor-A (VEGF), VEGFR-2, and VEGFR-3 in primary cutaneous melanomas with positive and negative sentinel node status (SLN) (a total of 58 specimens divided into 2 groups of 29 for each status). A quantification score was developed for protein expression, by considering the percentage of SLN+ tumour cells (0: 0%, 1: up to 1%, 2: 2-10%, 3: 11-50%, and 4: > 50%) in relation to the intensity of staining (0: negative, 1: low, 2: medium, 3: strong). Tumoural VEGFR-3 expression (mean ± standard deviation) in SLN+ tumours (9. Read More

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http://dx.doi.org/10.2340/00015555-3588DOI Listing

Trends in parotidectomy over 30 years in an Australian tertiary care center.

Head Neck 2020 Jul 3. Epub 2020 Jul 3.

Head and Neck Oncology, Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Background: Nomenclature, classification, and management of parotid tumors are constantly evolving; this study was performed to identify temporal trends in histology and facial nerve sacrifice in parotidectomy during a 30-year period (1987-2018).

Methods: Retrospective analysis of patients treated in a single tertiary-care institution during this time period was performed with analysis of temporal trends.

Results: Two thousand eight hundred and fifty-seven parotidectomies were performed; pleomorphic adenoma was the most common histology (34. Read More

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http://dx.doi.org/10.1002/hed.26335DOI Listing

Caution in the age of optimism; a salient lesson in advanced melanoma.

Ann Transl Med 2020 Jun;8(11):720

Department of Medical Oncology, Alfred Hospital, Melbourne, Australia.

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http://dx.doi.org/10.21037/atm.2020.01.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327371PMC