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    Skin Cancer Awareness Amongst Irish Golfers.
    Ir Med J 2017 Aug 12;110(7):620. Epub 2017 Aug 12.
    Department of Dermatology, South Infirmary Victoria University Hospital, Cork, Ireland.
    Aim The aim of this study was to assess skin cancer awareness and identify the UV protective measures used by golfers within the Munster region of Ireland. Methods Subjects were recruited from throughout the Munster region at a regional competition, and at three other local golf clubs and "pro" shops. Participants filled out a short anonymous validated questionnaire when collecting their score cards7. Read More

    Three year Experience of Non-Melanoma Skin Cancer in a General Practice.
    Ir Med J 2017 Aug 12;110(7):616. Epub 2017 Aug 12.
    edford Medical Centre, Navan.
    We report 85 lesions of non-melanoma skin cancer in 58 patients, representing 9% of the minor surgical workload of a single general practitioner. Cases were studied in order to describe pathology, management and outcomes. Eighteen percent of lesions were referred, mainly because of central facial site and larger size. Read More

    Treating malignant melanoma when a rare BRAF V600M mutation is present: case report and literature review.
    Rom J Intern Med 2017 Nov 27. Epub 2017 Nov 27.
    Recent years have brought major advances in the treatment of malignant melanoma. One such an advance is the treatment with BRAF tyrosine-kinase inhibitors in metastatic malignant melanomas that harbor mutations in the BRAF gene. The trials that have been performed in this setting have demonstrated superior response rates and increased overall survival, however they mostly included patients with melanomas carrying the more common V600E and V600K mutations, not being able to assess the benefit of these treatments in situations where more rare mutations of the BRAF gene are present. Read More

    Sampling of Wide Local Excision Specimens in Cutaneous Malignant Melanoma.
    J Cutan Pathol 2017 Nov 23. Epub 2017 Nov 23.
    Department of Pathology, Cork University Hospital, Wilton, Cork, Ireland.
    Background: Wide local excisions (WLE) are frequently undertaken in the management of cutaneous melanoma; however there is considerable variability in their macroscopic sampling. The aim of our study was to establish evidence-based guidelines for the macroscopic handling of these specimens with a subsequent review of the impact on our service.

    Methods: The study group of 128 cases with initial biopsy and subsequent WLE in our institution in 2010 were identified by a computer-generated search. Read More

    Multiplicity of skin cancers in Queensland and their cost burden to government and patients.
    Aust N Z J Public Health 2017 Nov 22. Epub 2017 Nov 22.
    QIMR Berghofer Medical Research Institute, Population Health Department, Queensland.
    Objective: To determine the cost burden to government and patients for individuals with multiple skin cancers.

    Methods: We used self-reported baseline data on socio-demographics, phenotype and sun exposure behaviours from participants in the QSkin Sun and Health Study with at least one histopathologically confirmed keratinocyte cancer or melanoma (n=5,673). Linkage to Australian Medicare data (2011-2014) provided resource data and government and out-of-pocket patient costs. Read More

    Synergistic inhibition of cell proliferation by combined targeting with kinase inhibitors and dietary xanthone is a promising strategy for melanoma treatment.
    Clin Exp Dermatol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    α-Mangostin is a dietary xanthone that displays various biological activities, and numerous reports have shown its efficacy in cancer prevention and inhibition. As most agents have been shown to be ineffective as single-agent therapy for malignant melanoma (MM), the principle of targeted chemotherapy for MM is to use effective inhibitors and combination methods. In this study, we tested the cytotoxicity of several kinase inhibitors, including the glycogen synthase kinase (GSK)-3 inhibitor CHIR99021, and rapamycin, in combination with a dietary xanthone, α-mangostin, by screening from a kinase inhibitor library for melanogenesis in SK-MEL-2 MM cells, and verified these by clone formation efficiency, terminal dUTP nick end labelling, and expression of apoptosis-related proteins. Read More

    Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.
    Sci Rep 2017 Nov 22;7(1):15996. Epub 2017 Nov 22.
    Department of Immunology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
    The induction of ectopic lymph node structures (ELNs) holds great promise to augment immunotherapy against multiple cancers including metastatic melanoma, in which ELN formation has been associated with a unique immune-related gene expression signature composed of distinct chemokines. To investigate the therapeutic potential of ELNs induction, preclinical models of ELNs are needed for interrogation of these chemokines. Computational models provide a non-invasive, cost-effective method to investigate leukocyte trafficking in the tumor microenvironment, but parameterizing such models is difficult due to differing assay conditions and contexts among the literature. Read More

    Wnt/β-catenin pathway activation mediates adaptive resistance to BRAF inhibition in colorectal cancer.
    Mol Cancer Ther 2017 Nov 22. Epub 2017 Nov 22.
    Parmacology and Chemical Biology, University of Pittsburgh Cancer Institute
    One of the most encouraging developments in oncology has been the success of BRAF inhibitors in BRAF-mutant melanoma. However, in contrast to its striking efficacy in BRAF-mutant melanomas, BRAF inhibitor monotherapy is ineffective in BRAF-mutant colorectal cancer (CRC). While many studies on BRAF inhibitor resistance in CRC have focused on mechanisms underlying the reactivation of the EGFR/RAS/RAF/MEK/ERK pathway, the current study focuses on identifying novel adaptive signaling mechanisms, a fresh angle on CRC resistance to BRAF inhibition. Read More

    BAP1: case report and insight into a novel tumor suppressor.
    BMC Dermatol 2017 Nov 22;17(1):13. Epub 2017 Nov 22.
    Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, 19104, USA.
    Background: BRCA1-Associated-Protein 1 (BAP1) is a dynamic tumor suppressor which, when mutated, has been associated with an increased risk of uveal melanoma, cutaneous melanoma, mesothelioma, and several other cancers. Germline BAP1 mutations have been extensively studied, where they have been found to cause hereditary cancer susceptibility. However, their sporadic counterparts, tumors that display a loss of BAP1 expression due to somatically arising mutations in the BAP1 gene, remain a poorly described entity. Read More

    Recruiting former melanoma patients via hospitals in comparison to office-based dermatologists in a register-based cohort study that required indirect contact.
    BMC Med Res Methodol 2017 Nov 22;17(1):150. Epub 2017 Nov 22.
    Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
    Background: There are detailed reviews about different recruitment strategies, but not with regard to differences between recruitment of hospital-based versus office-based physicians. Within this study, the two different recruitment schemes are compared. Advantages and disadvantages of different ways of recruitment in registry-based studies are discussed. Read More

    Cylindromatosis (CYLD), a Deubiquitinase, Attenuates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.
    Kidney Blood Press Res 2017 Nov 22;42(5):942-950. Epub 2017 Nov 22.
    Department of Pediatrics, Hirosaki, Japan.
    Background/aims: Cylindromatosis (CYLD), a deubiquitinase, negatively regulates nuclear factor-κB in various cells. However, its potential roles in glomerular inflammation remain unclear. Because the activation of the Toll-like receptor 3 (TLR3)/type I interferon (IFN) pathways plays a pivotal role in chronic kidney diseases (CKD), we examined the role of CYLD in the TLR3 signaling in cultured human mesangial cells (MCs). Read More

    Primary cutaneous amelanotic melanoma and gastrointestinal stromal tumor in synchronous evolution.
    An Bras Dermatol 2017 Sep-Oct;92(5):707-710
    Dermatology Service of Hospital Universitário Regional do Norte do Paraná (HURNP) - Universidade Estadual de Londrina (UEL) - Londrina (PR), Brazil.
    Gastrointestinal stromal tumor is rare digestive tract mesenchymal tumor, most often in the wall of the stomach. It is a benign neoplasm, but it can become malignant if not treated. We report a case of gastrointestinal stromal tumor that was discovered after abdominal ultrasonography during staging of a patient with primary cutaneous amelanotic melanoma. Read More

    Pigmented Bowen's disease associated with high-risk HPV simulating melanoma of the hand.
    An Bras Dermatol 2017 Sep-Oct;92(5):686-688
    Private clinic - Piracicaba (SP), Brazil.
    Bowen's disease is an in situ squamous cell carcinoma of the skin with only 2% of pigmented cases reported. It is clinically characterized by papules and plaques of blackened surface that may be caused either by sun damage - usually in photoexposed areas in elderly individuals - or by human papillomavirus infection - usually in the anogenital region of young adults. Dermoscopic aspects of Bowen's disease are discussed for over a decade, but with no definitive criteria that would lead to a definitive diagnosis. Read More

    Final diagnosis of 86 cases included in differential diagnosis of American tegumentary leishmaniasis in a Brazilian sample: a retrospective cross-sectional study.
    An Bras Dermatol 2017 Sep-Oct;92(5):642-648
    Division of Dermatology, Department of Medical Clinics, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP) - Ribeirão Preto (SP), Brazil.
    Background: Cutaneous leishmaniasis is distributed worldwide, including Brazil. Its several clinical forms need to be distinguished from other dermatoses. Clinical similarities and lack of a gold standard diagnostic tool make leishmaniasis-like lesions a challenging diagnosis. Read More

    Skin disorders in renal transplant recipients: a retrospective study.
    An Bras Dermatol 2017 Sep-Oct;92(5):638-641
    Unidade de Investigacao em Dermatologia, Faculdade de Medicina da Universidade de Lisboa (FMUL) - Lisbon, Portugal.
    Background: Immunosuppressive therapy, which is necessary to avoid graft rejection in renal transplant recipients, presents an increased risk of several pathologies, namely infectious and neoplastic.

    Objectives: To identify the most frequent skin diseases and their clinical and demographical risk factors within a population of renal transplant recipients.

    Methods: A retrospective study of renal transplant recipients referred to dermatology visit and observed for the first time from January 2008 to December 2014. Read More

    Juvenile xanthogranuloma with angiomatous appearance and a peculiar immunophenotype.
    Pediatr Dermatol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Dermatology, Hospital Universitario Fundacion Jiménez Diaz, Universidad Autónoma, Madrid, Spain.
    Juvenile xanthogranuloma is the most common form of non-Langerhans cell histiocytosis in childhood. The clinical differential diagnosis of a solitary juvenile xanthogranuloma includes molluscum contagiosum, Spitz nevus, and melanoma. Lesions larger than 2 cm in diameter may be misdiagnosed as hemangiomas, but this is not typical of smaller juvenile xanthogranuloma. Read More

    Metastasectomy following incomplete response to high-dose interleukin-2.
    J Surg Oncol 2017 Nov 22. Epub 2017 Nov 22.
    Division of Surgical Oncology, Rutgers University, New Brunswick, New Jersey.
    Objective: To evaluate our experience with metastasectomy following partial response or stable disease after treatment with high-dose interleukin-2 (HD IL-2).

    Methods: A total of 305 patients with metastatic renal cell carcinoma or melanoma treated with HD IL-2 over a 12-year period were reviewed. Age, objective response, and overall survival data were evaluated using standard RECIST criteria and Kaplan-Meier estimates. Read More

    Physician interpretation of genomic test results and treatment selection.
    Cancer 2017 Nov 22. Epub 2017 Nov 22.
    Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Background: Genomic testing is increasingly performed in oncology, but concerns remain regarding the clinician's ability to interpret results. In the current study, the authors sought to determine the agreement between physicians and genomic annotators from the Precision Oncology Decision Support (PODS) team at The University of Texas MD Anderson Cancer Center in Houston regarding actionability and the clinical use of test results.

    Methods: On a prospective protocol, patients underwent clinical genomic testing for hotspot mutations in 46 or 50 genes. Read More

    Human Protoparvoviruses.
    Viruses 2017 Nov 22;9(11). Epub 2017 Nov 22.
    Department of Virology, University of Helsinki, Helsinki 00290, Finland.
    Next-generation sequencing and metagenomics have revolutionized the discovery of novel viruses. In recent years, three novel protoparvoviruses have been discovered in fecal samples of humans: bufavirus (BuV) in 2012, tusavirus (TuV) in 2014, and cutavirus (CuV) in 2016. BuV has since been studied the most, disclosing three genotypes that also represent serotypes. Read More

    Nail apparatus melanoma in a Japanese population: a comparative study of surgical procedures and prognoses in a large series of 151 cases.
    Eur J Dermatol 2017 Nov 22. Epub 2017 Nov 22.
    Saitama Medical University, Department of Dermatology, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.
    Nail apparatus melanoma (NAM) is a rare subtype of malignant melanoma with a prevalence that varies among populations. Conservative surgical approaches for thin to intermediate NAMs have recently been reported, however, their adoption is controversial, and resulting long-term prognoses are unknown. The purpose of this study was to determine the prognosis of NAM in a sample Asian population, and to investigate whether there is a difference in the local control and overall survival (OS) rates according to the extent of resection of the primary tumour. Read More

    Digital clubbing as a first clinical presentation of pulmonary metastases in cutaneous melanoma.
    Postgrad Med 2017 Nov 22. Epub 2017 Nov 22.
    a Department of Medical Oncology, Institute of Oncology , University of Istanbul , Istanbul , TURKEY.
    Digital clubbing is a paraneoplastic phenomenon usually associated with non-small cell lung cancer. We report the development of clubbing in a 49-year old man diagnosed with cutaneous melanoma which had metastasized to the lungs. We also reviewed the literature to understand the association between metastatic melanoma and clubbing. Read More

    Down-regulating Myoferlin inhibits the vasculogenic mimicry of melanoma via decreasing MMP-2 and inducing mesenchymal-to-epithelial transition.
    J Cell Mol Med 2017 Nov 22. Epub 2017 Nov 22.
    Tianjin Medical University General Hospital, Tianjin Medical University Cancer Institute and Hospital, School of Basic Medical Sciences, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China.
    Vasculogenic mimicry (VM) constitutes a novel approach for tumour blood supply and contributes to tumour metastasis and poor prognosis in patients with melanoma. Myoferlin (MYOF), a type II membrane protein involved in membrane regeneration and repair, is elevated in several malignant tumours, especially in advanced melanomas. This study aims to investigate the role and mechanism of MYOF in the regulation of VM. Read More

    Immune correlates of clinical outcome in melanoma.
    Immunology 2017 Nov 21. Epub 2017 Nov 21.
    Second Department of Internal Medicine, University of Tuebingen Center for Medical Research (ZMF), Waldhoernlestr. 22, D-72072, Tuebingen, Germany.
    Melanoma has long been recognized as a potentially immunogenic tumour, but only recently has it become clear that the reason for this resides in its many UV-induced mutations and expression of multiple autoantigens which can be targeted by the immune system. The first successful applications of immune-based treatments included passive immunotherapy using high-dose IL-2 and/or adoptive transfer of NK-cells, as well as active immunotherapy using whole cell-derived or peptide vaccines. In the intervening decades, it has become clear that these approaches can lead to durable responses in stage III/IV melanoma, and even to functional cures - but only in a vanishingly small fraction of patients. Read More

    Advanced Melanoma: Current Treatment Options, Biomarkers, and Future Perspectives.
    Am J Clin Dermatol 2017 Nov 21. Epub 2017 Nov 21.
    Department of Medical Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
    Malignant melanoma accounts for the highest number of deaths from skin cancer, and the prognosis of patients with stage IV disease has historically been poor. Novel insights into both mutations driving tumorigenesis and immune escape mechanisms of these tumors have led to effective treatment options that have revolutionized the treatment of this disease. Targeting the MAPK kinase pathway (with BRAF and MEK inhibitors), as well as targeting checkpoints, such as cytotoxic T-lymphocyte associated protein 4 (CTLA-4) or programmed death 1 (PD-1), have improved overall survival in patients with late-stage melanoma, and biomarker research for personalized therapy is ongoing for each of these treatment modalities. Read More

    Cancer incidence in Stockholm firefighters 1958-2012: an updated cohort study.
    Int Arch Occup Environ Health 2017 Nov 21. Epub 2017 Nov 21.
    Unit of Occupational Medicine, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Objectives: Previous studies on firefighters indicate an increased risk of cancer although findings regarding which cancer sites are in excess have been inconsistent. The aim of this study was to investigate the cancer incidence among Swedish firefighters.

    Methods: This updated cohort study included 1080 men who worked at least 1 year as a firefighter in the city of Stockholm, Sweden during 1931-1983. Read More

    Expression of cancer/testis antigens MAGE-A, MAGE-C1, GAGE and CTAG1B in benign and malignant thyroid diseases.
    Oncol Lett 2017 Dec 26;14(6):6485-6496. Epub 2017 Sep 26.
    Division of Pathology Diagnostic Services, Cytology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
    Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. Read More

    Detection of Somatic Mutations in Exome Sequencing of Tumor-only Samples.
    Sci Rep 2017 Nov 21;7(1):15959. Epub 2017 Nov 21.
    Institute of Statistical Science, Academia Sinica, Taipei 115, Taiwan, R.O.C..
    Due to lack of normal samples in clinical diagnosis and to reduce costs, detection of small-scale mutations from tumor-only samples is required but remains relatively unexplored. We developed an algorithm (GATKcan) augmenting GATK with two statistics and machine learning to detect mutations in cancer. The averaged performance of GATKcan in ten experiments outperformed GATK in detecting mutations of randomly sampled 231 from 241 TCGA endometrial tumors (EC). Read More

    Outcomes of patients with sarcoma enrolled in clinical trials of pazopanib combined with histone deacetylase, mTOR, Her2, or MEK inhibitors.
    Sci Rep 2017 Nov 21;7(1):15963. Epub 2017 Nov 21.
    Department of Investigational Cancer Therapeutics (Phase 1 Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Pazopanib is US FDA approved for the treatment of advanced soft tissue sarcomas. All patients with this disease ultimately develop resistance to therapy. Mechanisms of resistance include activation of the mTOR, histone deacetylase (HDAC), MAPK, and ERBB4 pathways. Read More

    Expression signatures of early-stage and advanced medaka melanomas.
    Comp Biochem Physiol C Toxicol Pharmacol 2017 Nov 18. Epub 2017 Nov 18.
    Physiological Chemistry, Biocenter, University of Wuerzburg, Am Hubland, 97074, Wuerzburg, Germany; Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany; Hagler Institute for Advanced Study and Department of Biology, Texas A&M University, College Station, TX, 77843, USA. Electronic address:
    Melanoma is one of the most aggressive tumors with a very low survival rate once metastasized. The incidence of newly detected cases increases every year suggesting the necessity of development and application of innovative treatment strategies. Human melanoma develops from melanocytes localized in the epidermis of the skin to malignant tumors because of deregulated effectors influencing several molecular pathways. Read More

    Serial pseudoprogression of metastatic malignant melanoma in a patient treated with nivolumab: a case report.
    BMC Cancer 2017 Nov 21;17(1):778. Epub 2017 Nov 21.
    Department of Medical Oncology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, Tokyo, 105-8470, Japan.
    Background: Pseudoprogression refers to a specific pattern of response sometimes observed in malignant melanoma patients receiving treatment with immune-checkpoint inhibitors. Although cases with pseudoprogression documented once have been reported previously, there have been no case reports yet of pseudoprogression events documented twice during treatment.

    Case Presentation: A 55-year-old man underwent surgery for locally advanced esophageal malignant melanoma and received postoperative adjuvant interferon therapy. Read More

    Multi-Institutional Competing Risks Analysis of Distant Brain Failure and Salvage Patterns after Upfront Radiosurgery without Whole Brain Radiotherapy for Brain Metastasis.
    Ann Oncol 2017 Nov 17. Epub 2017 Nov 17.
    Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
    Background: In this study we use a competing risks analysis to assess factors predictive of early salvage whole brain radiotherapy (WBRT) and early death after upfront stereotactic radiosurgery (SRS) alone for brain metastases in an attempt to identify populations that benefit less from upfront SRS.

    Patients And Methods: Patients from eight academic centers were treated with SRS for brain metastasis. Competing risks analysis was performed for distant brain failure (DBF) vs. Read More

    Retin Cases Brief Rep 2017 Apr 17. Epub 2017 Apr 17.
    Departments of *Ophthalmology, and†Dermatology and Allergology, Ludwig-Maximilians-University, Munich, Germany.
    Introduction: Although the introduction of BRAF and MEK inhibitors has greatly enhanced treatment possibilities in advanced BRAFV600-mutated melanoma, class-related toxicities are rather frequent and often involve the eye. Ophthalmologic side effects most commonly include central/diffuse serous retinopathy and retinal vein occlusion. Affection of the optic nerve head however has not been described clinically. Read More

    Insect cuticular melanins are distinctly different from those of mammalian epidermal melanins.
    Pigment Cell Melanoma Res 2017 Nov 21. Epub 2017 Nov 21.
    Fujita Health University, School of health Sciences, Toyoake, Aichi, Japan.
    Melanin from several insect samples were isolated and subjected to chemical degradation and HPLC analysis for melanin markers. Quantification of different melanin markers reveals that insect melanins are significantly different from that of the mammalian epidermal melanins. The eumelanin produced in mammals are derived from the oxidative polymerization of both 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid. Read More

    The unveiling of the Warburg effect and the inscribed innovative approach to a radical non toxic anticancer therapy.
    Cell Cycle 2017 Nov 21:1-28. Epub 2017 Nov 21.
    a Department Biomedical , Experimental and Clinical Sciences , University of Firenze , Viale Morgagni, 50-50134.
    The purpose of this research has been deciphering the Warburg paradox, the biochemical enigma unsolved since 1923. This paradox consists of the aerobic pyruvate conversion to lactate brought about by anaplastic cancer, through the metabolic pathway known as aerobic glycolysis. This pathway implies a heavy energetic waste. Read More

    Nevi and lasers: Practical considerations.
    Lasers Surg Med 2017 Nov 21. Epub 2017 Nov 21.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Lasers are increasingly used for elective ablation of melanocytic nevi (MN). However, the associated risks of treating MN with lasers are debated and not well studied. Theoretical risks include inadvertently treating a melanoma mistaken for a nevus, the inability to remove all nevus cells and the possibility for residual cells to undergo malignant transformation, and the difficulty in clinically monitoring the remnant nevus for melanoma progression. Read More

    Prevalence of sun protection behaviors in Hispanic youth residing in a high ultraviolet light environment.
    Pediatr Dermatol 2017 Nov 21. Epub 2017 Nov 21.
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
    Although rates of late-stage melanoma are rising in Hispanics, particularly those living in high ultraviolet light environments, little is known about the prevalence of sun protective behaviors in Hispanic children. We analyzed baseline data including frequency of sunburn, sun protective behaviors, level of U.S. Read More

    Risk of leptomeningeal carcinomatosis in patients with brain metastases treated with stereotactic radiosurgery.
    J Neurooncol 2017 Nov 20. Epub 2017 Nov 20.
    Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, 195 Little Albany Street, New Brunswick, NJ, 08901, USA.
    There is limited available literature examining factors that predispose patients to the development of LMC after stereotactic radiosurgery (SRS) for brain metastases. We sought to evaluate risk factors that may predispose patients to LMC after SRS treatment in this case-control study of patients with brain metastases who underwent single-fraction SRS between 2011 and 2016. Demographic and clinical information were collected retrospectively for 19 LMC cases and 30 controls out of 413 screened patients with brain metastases. Read More

    Japan Society of Gynecologic Oncology guidelines 2015 for the treatment of vulvar cancer and vaginal cancer.
    Int J Clin Oncol 2017 Nov 20. Epub 2017 Nov 20.
    Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
    Background: Vulvar cancer and vaginal cancer are relatively rare tumors, and there had been no established treatment principles or guidelines to treat these rare tumors in Japan. The first version of the Japan Society of Gynecologic Oncology (JSGO) guidelines for the treatment of vulvar cancer and vaginal cancer was published in 2015 in Japanese.

    Objective: The JSGO committee decided to publish the English version of the JSGO guidelines worldwide, and hope it will be a useful guide to physicians in a similar situation as in Japan. Read More

    Morbidity and Outcomes Following Axillary Lymphadenectomy for Melanoma: Weighing the Risk of Surgery in the Era of MSLT-II.
    Ann Surg Oncol 2017 Nov 20. Epub 2017 Nov 20.
    Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
    Background: Limited data exist characterizing complications after axillary lymphadenectomy for melanoma. With high rates of complications reported after dissection for breast cancer and data suggesting that completion lymphadenectomy may have limited therapeutic benefit, this study characterized morbidity to facilitate clinical decision-making.

    Methods: Using a broad definition for complications, patients who underwent axillary dissection for melanoma at a single center (from 2003 to 2015) were assessed through retrospective chart review. Read More

    Safety of clomiphene citrate: a literature review.
    Cytotechnology 2017 Nov 20. Epub 2017 Nov 20.
    Gazi University Vocational School of Health Services, Gölbaşı, Ankara, Turkey.
    Clomiphene citrate (CC) is a nonsteroidal compound and induces ovulation indirectly. The wide usage of the CC raises a question; is it safe or not? In the light of this question, this review aimed to highlight all researches and insights into the association between the use of CC and risk of genotoxicity, cytotoxicity, embryotoxicity, teratogenicity and risk of different cancer types. We conducted a MEDLINE/PubMed, Scopus, Web of Science, Google Scholar search. Read More

    Myasthenia Gravis Induced by Nivolumab: A Case Report.
    Cureus 2017 Sep 20;9(9):e1702. Epub 2017 Sep 20.
    Cancer Center of Kansas, University of Kansas School of Medicine - Wichita.
    Nivolumab is a programmed cell death receptor (PD-1) inhibitor therapy for aggressive cancers; however, it poses a risk of immune-related adverse side effects. We present a 73-year-old male with renal cell carcinoma who developed myasthenia gravis (MG) after being treated with nivolumab, proven by acetylcholine receptor antibodies. Our patient presented with symptoms of fatigue and upper and lower extremity weakness, eventually resulting in respiratory failure as a result of MG. Read More

    Linear Malignant Melanoma In Situ: Reports and Review of Cutaneous Malignancies Presenting as Linear Skin Cancer.
    Cureus 2017 Sep 18;9(9):e1696. Epub 2017 Sep 18.
    Department of Dermatology, University of California, San Diego.
    Melanomas usually present as oval lesions in which the borders may be irregular. Other morphological features of melanoma include clinical asymmetry, variable color, diameter greater than 6 mm and evolving lesions. Two males whose melanoma in situ presented as linear skin lesions are described and cutaneous malignancies that may appear linear in morphology are summarized in this report. Read More

    Ginsenoside Rk1 bioactivity: a systematic review.
    PeerJ 2017 17;5:e3993. Epub 2017 Nov 17.
    Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
    Ginsenoside Rk1 (G-Rk1) is a unique component created by processing the ginseng plant (mainly Sung Ginseng (SG)) at high temperatures. The aim of our study was to systematically review the pharmacological effects of G-Rk1. We utilized and manually searched eight databases to select in vivo and in vitro original studies that provided information about biological, pharmaceutical effects of G-Rk1 and were published up to July 2017 with no restriction on language or study design. Read More

    Gastric and Rectal Metastases from Malignant Melanoma Presenting with Hypochromic Anemia and Treated with Immunotherapy.
    Case Rep Oncol Med 2017 12;2017:2079068. Epub 2017 Oct 12.
    Medical Oncology Unit, Dipartimento di Scienze Chirurgiche, Oncologiche e Stomatologiche, University of Palermo, Palermo, Italy.
    The authors present a case of an 80-year-old Caucasian male with multiple gastric and rectal metastases from malignant melanoma presenting with hypochromic anemia as the sole symptom of disease without evidence of cutaneous and ocular tumor localization. The patient had a medical history positive for malignant lentigo melanoma of the occipital region of the scalp and early stage laryngeal squamous cell carcinoma and prostatic carcinoma treated with radiation therapy. The authors make some considerations on intestinal involvement by metastatic melanoma and discuss the choice of not treating with endoscopic procedures the gastric metastatic lesions most likely responsible for the clinical sign present at diagnosis. Read More

    Rational design of Polymeric Hybrid Micelles to Overcome Lymphatic and Intracellular Delivery Barriers in Cancer Immunotherapy.
    Theranostics 2017 26;7(18):4383-4398. Epub 2017 Sep 26.
    Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
    Poor distribution of antigen/adjuvant to target sites and inadequate induction of T cell responses remain major challenges in cancer immunotherapy because of the lack of appropriate delivery systems. Nanocarrier-based antigen delivery systems have emerged as an innovative strategy to improve vaccine efficacy. Here we present polymeric hybrid micelles (PHMs) as a simple and potent antigen/adjuvant co-delivery system with highly tunable properties. Read More

    Therapeutic Anticoagulation in Patients with Primary Brain Tumors or Secondary Brain Metastasis.
    Oncologist 2017 Nov 20. Epub 2017 Nov 20.
    Memorial Sloan Kettering Cancer Center, New York City, New York, USA.
    Patients with primary or metastatic brain tumors are at increased risk of developing venous thromboses. However, the potential benefit of therapeutic anticoagulation in these patients must be weighed against the deadly complication of intracranial hemorrhage. In this review, we summarize available evidence and recent studies of intracranial bleeding risks in primary and metastatic tumors and the impact of therapeutic anticoagulation. Read More

    Tumour-adipose tissue crosstalk: fuelling tumour metastasis by extracellular vesicles.
    Philos Trans R Soc Lond B Biol Sci 2018 Jan;373(1737)
    Microenvironment and Metastasis Group, Department of Molecular Oncology, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain
    During metastasis, tumour cells must communicate with their microenvironment by secreted soluble factors and extracellular vesicles. Different stromal cell types (e.g. Read More

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