125,780 results match your criteria Malignant Melanoma


YY1 regulates cancer cell immune resistance by modulating PD-L1 expression.

Drug Resist Updat 2019 Apr 9;43:10-28. Epub 2019 Apr 9.

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, United States. Electronic address:

Recent advances in the treatment of various cancers have resulted in the adaptation of several novel immunotherapeutic strategies. Notably, the recent intervention through immune checkpoint inhibitors has resulted in significant clinical responses and prolongation of survival in patients with several therapy-resistant cancers (melanoma, lung, bladder, etc.). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13687646193001
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http://dx.doi.org/10.1016/j.drup.2019.04.001DOI Listing
April 2019
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An updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for pathological evaluation of sentinel lymph nodes for melanoma.

Eur J Cancer 2019 Apr 17;114:1-7. Epub 2019 Apr 17.

Department of Surgical Oncology, Netherlands Cancer Institute Antoni van Leeuwenhoek, Amsterdam, the Netherlands.

The sentinel lymph node (SLN) biopsy is a highly accurate staging procedure and the most important prognostic factor in melanoma patients. The European Organisation for Research and Treatment of Cancer (EORTC) Melanoma Group aimed to design an updated evolved SLN protocol for the histopathological workup and reporting. We herein recommend extending the distance between steps according to the short axis dimension of the lymph node and optimise both conventional sectioning and staining procedures including immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.03.010DOI Listing

A Psoriasiform Drug Eruption Secondary to Nivolumab for Hepatocellular Carcinoma: a Case Report.

Hepatology 2019 Apr 20. Epub 2019 Apr 20.

Corporal Michael J Crescenz VA Medical Center, Pathology, 3900 Woodland Avenue, Philadelphia, Pennsylvania, United States.

Nivolumab, an immune checkpoint inhibitor that acts by preventing programmed-death ligand 1 (PD-L1) from binding to the programmed cell death protein-1 (PD-1) receptor, is utilized to treat a variety of cancers including renal cell carcinoma, non-small cell lung cancer, and metastatic melanoma. Currently, nivolumab is FDA-approved as a second-line treatment for advanced hepatocellular carcinoma (HCC) after showing efficacy in patients who progressed on or were intolerant to sorafenib. This article is protected by copyright. Read More

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http://dx.doi.org/10.1002/hep.30659DOI Listing

Integrative Analysis of Long Noncoding RNA (lncRNA), microRNA (miRNA) and mRNA Expression and Construction of a Competing Endogenous RNA (ceRNA) Network in Metastatic Melanoma.

Med Sci Monit 2019 Apr 20;25:2896-2907. Epub 2019 Apr 20.

Department of Dermatology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, Shandong, China (mainland).

Worldwide, metastatic melanoma of the skin has an aggressive course with high morbidity and mortality. Therefore, an increased understanding of the pathogenesis of metastatic melanoma has gained increasing attention, including the role of epigenetic modification and competing endogenous RNA (ceRNA). This study aimed to used bioinformatics data to undertake an integrative analysis of long noncoding RNA (lncRNA), microRNA (miRNA) and mRNA expression to construct a ceRNA network in metastatic melanoma. Read More

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http://dx.doi.org/10.12659/MSM.913881DOI Listing
April 2019
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Malignant melanoma in the pelvic cavity mimicking a gastrointestinal stromal tumor.

Dig Liver Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology, Aichi Medical University, Nagakute, Aichi, Japan.

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http://dx.doi.org/10.1016/j.dld.2019.03.017DOI Listing

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents.

Antioxidants (Basel) 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK.

Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g. Read More

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http://dx.doi.org/10.3390/antiox8040106DOI Listing

PMN-MDSCs Enhance CTC Metastatic Properties through Reciprocal Interactions via ROS/Notch/Nodal Signaling.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Biomarker Research Program Center, Houston Methodist Research Institute, Houston, TX 77030, USA.

Intratumoral infiltration of myeloid-derived suppressor cells (MDSCs) is known to promote neoplastic growth by inhibiting the tumoricidal activity of T cells. However, direct interactions between patient-derived MDSCs and circulating tumors cells (CTCs) within the microenvironment of blood remain unexplored. Dissecting interplays between CTCs and circulatory MDSCs by heterotypic CTC/MDSC clustering is critical as a key mechanism to promote CTC survival and sustain the metastatic process. Read More

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http://dx.doi.org/10.3390/ijms20081916DOI Listing

Cisplatin: The first metal based anticancer drug.

Authors:
Sumit Ghosh

Bioorg Chem 2019 Apr 11;88:102925. Epub 2019 Apr 11.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India. Electronic address:

Cisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways which finally lead to apoptosis. However, side effects and drug resistance are the two inherent challenges of cisplatin which limit its application and effectiveness. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.102925DOI Listing
April 2019
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Single visit PDT for basal cell carcinoma - a new therapeutic protocol.

Photodiagnosis Photodyn Ther 2019 Apr 16. Epub 2019 Apr 16.

Skin Department, Foundation Hospital Amaral Carvalho, Jau, São Paulo, Brazil. Electronic address:

Non-melanoma skin cancer is the most prevalent type of cancer in Brazil and worldwide. Topical Photodynamic Therapy is a technique that offers advantages as: excellent aesthetic result, possibility of application for outpatients in ambulatory, and presenting a minimum functional impact of the treated anatomycal site. Fractionated Photodynamic Therapy is a modification of the usual technique in which the full dose of light is delivered in steps separated by a periods of time ("dark intervals"). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000193012
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http://dx.doi.org/10.1016/j.pdpdt.2019.04.016DOI Listing
April 2019
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Analysis of the proteasome activity and the turnover of the serotonin 2B (HTR2B) receptor in human uveal melanoma.

Exp Eye Res 2019 Apr 16. Epub 2019 Apr 16.

CUO-Recherche, Médecine Régénératrice, Centre de Recherche FRQS du CHU de Québec, Université Laval, Québec, Canada; Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Québec, Canada; Département d'Ophtalmologie, Faculté de Médecine, Université Laval, Québec, QC, Canada. Electronic address:

Uveal melanoma (UM), although a very rare disease, remains a particularly aggressive type of cancer as near 50% of the UM presenting patients will also develop liver metastases within 15 years from the initial diagnostic. One of the most reliable predictive markers of UM at risk of evolving toward the formation of liver lesions is an abnormally elevated level of expression of the transcript encoding the 5-Hydroxytryptamine (serotonin) receptor 2B (HTR2B). In our previous study, we demonstrated that transcription of the HTR2B gene was under the regulatory influences of two transcription factors (TFs), NFI and RUNX1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835193010
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http://dx.doi.org/10.1016/j.exer.2019.04.013DOI Listing
April 2019
2 Reads

The Role of Melanin in Skin Cancer.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):17-24

Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.

Low melanin level in white skin results in many genetic alterations that activate oncogenes to form metastatic melanomas because of interaction with ultraviolet rays. These melanomas are uncommon, but they are dangerous and spread rapidly in the individual's body. Individuals with fair, freckled skin; a weak immune system; or have a personal or family history of melanoma are at high risk to have melanoma. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2018024980DOI Listing
January 2019

Effect of electrochemotherapy with betulinic acid or cisplatin on regulation of heat shock proteins in metastatic human carcinoma cells in vitro.

Oncol Rep 2019 Apr 8. Epub 2019 Apr 8.

Department of Molecular and Cellular Biology, Faculty of Pharmacy with Division of Laboratory Diagnostics, Wroclaw Medical University, 50‑556 Wroclaw, Poland.

Betulinic acid (BTA) is naturally occurring triterpene that has received interest as a novel therapeutic substance with cytotoxicity towards a number of cancer cell lines. Despite the wide spectrum of biological and pharmacological effects, its effect may be limited its lipophobic properties. Therefore, strategies to improve the access of BTA to the cells are required to enhance the anticancer effects. Read More

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http://dx.doi.org/10.3892/or.2019.7103DOI Listing

Could Hepatitis B Vaccine Act as An Adjuvant to Lower Risk and Relapses of Cancer?

Clin Exp Pharmacol Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Acibadem University, İstanbul, Turkey.

In this review article, we hypothesize that Hepatitis B Virus Vaccine (HBV-V) and certain antigens of Hepatitis B Virus (HBV)-could act as anticancer immunoadjuvants in addition to their role of preventing HBV-associated liver cancer. Evidence suggests that in animal breast cancer and melanoma models, combining hepatitis B-surface antigen (HBsAg) with other cancer antigens resulted in enhanced antitumor activity. HBsAg shares antigenic mimicry with healthy and malignant cells including squamous epithelia, thymic epithelia, bladder- and colon cancer cells. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13
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http://dx.doi.org/10.1111/1440-1681.13096DOI Listing
April 2019
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Long noncoding RNA DSCAM-AS1 is associated with poor clinical prognosis and contributes to melanoma development by sponging miR-136.

Authors:
Y-L Huang Q Xu X Wang

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2888-2897

Department of Dermatology, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China.

Objective: Accumulating evidence suggests that long non-coding RNAs (lncRNAs) are playing critical roles in tumorigenesis. The present study aimed to investigate the expression pattern and effects of lncRNA DSCAM-AS1 (DSCAM-AS1) that was a newly discovered lncRNA in melanoma.

Patients And Methods: Real-time quantitative PCR (polymerase chain reaction) was performed to determine the expression of DSCAM-AS1 in melanoma tissues and cell lines. Read More

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http://www.europeanreview.org/article/17567
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http://dx.doi.org/10.26355/eurrev_201904_17567DOI Listing
April 2019
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LncRNA PVT1 knockdown affects proliferation and apoptosis of uveal melanoma cells by inhibiting EZH2.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2880-2887

School of Medicine, Nankai University, Tianjin, China.

Objective: To detect the expression of long non-coding ribonucleic acid (lncRNA) plasmacytoma variant translocation gene 1 (PVT1) in uveal melanoma (UM) tissues, and to investigate its influence on the proliferation and apoptosis of UM cells as well as its mechanism.

Patients And Methods: 40 cases of UM tissues and 40 cases of adjacent tissues surgically resected in our hospital from October 2015 to April 2018 were collected. The expression level of lncRNA PVT1 in these tissues was determined by Reverse Transcription-Polymerase Chain Reaction (RT-PCR). Read More

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http://www.europeanreview.org/article/17566
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http://dx.doi.org/10.26355/eurrev_201904_17566DOI Listing
April 2019
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Current Knowledge of Ipilimumab and its use in Treating Non-small Cell Lung cancer.

Expert Opin Biol Ther 2019 Apr 19. Epub 2019 Apr 19.

d Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine , Baltimore , MD , USA.

Introduction: The systemic treatment of non-small cell lung cancer (NSCLC) has changed dramatically with the identification of actionable mutations and the use of targeted agents. Unfortunately, many tumors will acquire resistance and >75% of NSCLC cases lack for an actionable gene aberration. In this setting, immunotherapy rises as effective therapeutic where immune checkpoint inhibitors have entered or are entering the market in many neoplasms, including NSCLC. Read More

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https://www.tandfonline.com/doi/full/10.1080/14712598.2019.1
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http://dx.doi.org/10.1080/14712598.2019.1610380DOI Listing
April 2019
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A novel CDKN2A variant (p16 ) in a patient with familial and multiple primary melanomas.

Pigment Cell Melanoma Res 2019 Apr 18. Epub 2019 Apr 18.

Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah.

Germline mutations in CDKN2A (p16) are commonly found in patients with family history of melanoma or personal history of multiple primary melanomas. The p16 tumor suppressor gene regulates cell cycle progression and senescence through binding of cyclin-dependent kinases (CDK) and also regulates cellular oxidative stress independently of cell cycle control. We identified a germline missense (c. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pcmr.12787
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http://dx.doi.org/10.1111/pcmr.12787DOI Listing
April 2019
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Meningeal enhancement depicted by magnetic resonance imaging in tumor patients: neoplastic meningitis or therapy-related enhancement?

Neuroradiology 2019 Apr 18. Epub 2019 Apr 18.

Diagnostic and Interventional Neuroradiology, Eberhard Karls University Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

Purpose: To assess the prevalence of false-positive meningeal contrast enhancement in patients with solid tumors who were undergoing chemotherapy.

Methods: A total of 2572 magnetic resonance imaging (MRI) examinations of the brain were retrospectively evaluated by two readers for the presence of pathological meningeal contrast enhancement conspicuous for neoplastic meningitis. These patients either had malignant melanoma, breast or lung cancer, or lymphoma. Read More

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http://link.springer.com/10.1007/s00234-019-02215-y
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http://dx.doi.org/10.1007/s00234-019-02215-yDOI Listing
April 2019
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Automatic skin lesion segmentation by coupling deep fully convolutional networks and shallow network with textons.

J Med Imaging (Bellingham) 2019 Apr 15;6(2):024001. Epub 2019 Apr 15.

University of Lincoln, Laboratory of Vision Engineering, School of Computer Science, Lincoln, United Kingdom.

Segmentation of skin lesions is an important step in computer-aided diagnosis of melanoma; it is also a very challenging task due to fuzzy lesion boundaries and heterogeneous lesion textures. We present a fully automatic method for skin lesion segmentation based on deep fully convolutional networks (FCNs). We investigate a shallow encoding network to model clinically valuable prior knowledge, in which spatial filters simulating simple cell receptive fields function in the primary visual cortex (V1) is considered. Read More

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http://dx.doi.org/10.1117/1.JMI.6.2.024001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462764PMC
April 2019
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Radiotherapy Both Promotes and Inhibits Myeloid-Derived Suppressor Cell Function: Novel Strategies for Preventing the Tumor-Protective Effects of Radiotherapy.

Front Oncol 2019 2;9:215. Epub 2019 Apr 2.

Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, United States.

Cancer immunotherapies aimed at neutralizing the programmed death-1 (PD-1) immune suppressive pathway have yielded significant therapeutic efficacy in a subset of cancer patients. However, only a subset of patients responds to antibody therapy with either anti-PD-1 or anti-PD-L1 antibodies. These patients appear to have so-called "hot" tumors containing tumor-reactive T cells. Read More

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http://dx.doi.org/10.3389/fonc.2019.00215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454107PMC

Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms.

Sci Rep 2019 Apr 18;9(1):6272. Epub 2019 Apr 18.

Division of Cancer-Hull York Medical School, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.

The bidirectional association between coagulation and cancer has been established. However, anticoagulant therapies have been reported to have beneficial outcomes by influencing the vascularisation of the tumours. In this study the influence of a set of anticoagulants on tumour formation, invasion and vascularisation was examined. Read More

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http://dx.doi.org/10.1038/s41598-019-42738-1DOI Listing

A potential function of RLIP76 in the ovarian corpus luteum.

J Ovarian Res 2019 Apr 18;12(1):34. Epub 2019 Apr 18.

College of Animal Life Sciences, Kangwon National University, Chuncheon, 24341, Republic of Korea.

Ral interacting protein of 76 kDa (RLIP76) is multifunctional protein localized and distributed in the plasma membrane, cytosol, and nucleus of the cell. In tumorigenesis, RLIP76 emerges as a common feature for the solid tumor growth. RLIP76 is ubiquitously expressed in various tissues including the ovary. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-019-0510-8DOI Listing
April 2019
1 Read

VIGLA-M: visual gene expression data analytics.

BMC Bioinformatics 2019 Apr 18;20(Suppl 4):150. Epub 2019 Apr 18.

Khaos Research, Universidad de Málaga, Málaga, Spain, Arquitecto Francisco Peñalosa 18, Málaga, 29071, Spain.

Background: The analysis of gene expression levels is used in many clinical studies to know how patients evolve or to find new genetic biomarkers that could help in clinical decision making. However, the techniques and software available for these analyses are not intended for physicians, but for geneticists. However, enabling physicians to make initial discoveries on these data would benefit in the clinical assay development. Read More

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http://dx.doi.org/10.1186/s12859-019-2695-7DOI Listing

Advances in the Understanding of Skin Cancer: Ultraviolet Radiation, Mutations, and Antisense Oligonucleotides as Anticancer Drugs.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, Crimea.

Skin cancer has always been and remains the leader among all tumors in terms of occurrence. One of the main factors responsible for skin cancer, natural and artificial UV radiation, causes the mutations that transform healthy cells into cancer cells. These mutations inactivate apoptosis, an event required to avoid the malignant transformation of healthy cells. Read More

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http://dx.doi.org/10.3390/molecules24081516DOI Listing

[Peripheral Exudative Hemorrhagic Chorioretinopathy (PEHCR) Simulating a Malignant Melanoma of the Choroid].

Klin Monbl Augenheilkd 2019 Apr 18;236(4):575-577. Epub 2019 Apr 18.

Augenklinik, Universitätsmedizin (UMC) der Johannes-Gutenberg Universität, Mainz.

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http://dx.doi.org/10.1055/a-0832-1770DOI Listing

Distant Subconjunctival Recurrences following Proton Therapy for a Choroidal Melanoma with Extrascleral Extension.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):422-424. Epub 2019 Apr 18.

Jules-Gonin Eye Hospital, Department of Ophthalmology, University of Lausanne, FAA, Switzerland.

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http://dx.doi.org/10.1055/a-0796-6299DOI Listing

Psychological Impact of Learning CDKN2A Variant Status as a Genetic Research Result.

Public Health Genomics 2019 Apr 18;21(3-4):154-163. Epub 2019 Apr 18.

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA,

Objectives: Little is known about genetic research participants' responses to receiving individual research results (IRR) from cancer genetic research. We examined the immediate and delayed psychological impact of returning a CDKN2A variant result that is associated with increased risk of pancreatic cancer and melanoma.

Methods: One hundred and thirty-three pancreas research registry enrollees whose samples were tested in a research laboratory for the CDKN2A variant were invited by mail to learn the result by telephone and participate in a study about the disclosure process. Read More

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https://www.karger.com/Article/FullText/496556
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http://dx.doi.org/10.1159/000496556DOI Listing
April 2019
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A Comparative Study of Google Search Trends for Melanoma, Breast Cancer and Prostate Cancer in Finland.

Dermatology 2019 Apr 18:1-2. Epub 2019 Apr 18.

Aava Kamppi Medical Centre, Helsinki, Finland.

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https://www.karger.com/Article/FullText/498987
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http://dx.doi.org/10.1159/000498987DOI Listing
April 2019
2 Reads

Automated in vivo screen in zebrafish identifies clotrimazole as targeting a metabolic vulnerability in a melanoma model.

Dev Biol 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Experimental Cancer Biology, CIBIO Department, University of Trento, Via Sommarive 9, 38123 Povo TN, Italy. Electronic address:

Therapeutic approaches for cutaneous melanoma are flourishing, but despite promising results, there is an increasing number of reported primary or secondary resistance to the growing sets of drugs approved for therapy in the clinics. Combinatorial approaches may overcome resistance, as they may tackle specific weaknesses of melanoma cells, not sufficient on their own, but effective in combination with other therapies. The transgenic zebrafish line kita:ras develops melanoma with high frequency. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.04.005DOI Listing

Oral Melanomas: A Case Series of a Deadly Neoplasm.

J Oral Maxillofac Surg 2019 Mar 26. Epub 2019 Mar 26.

Oral and Maxillofacial Surgery Attending, University of Florida College of Dentistry, Gainesville, FL.

Purpose: To describe and discuss the demographic and clinical features of oral melanomas, which are relatively rare but deadly neoplasms, and list the criteria for their diagnosis to increase early detection.

Materials And Methods: An institutional review board-approved retrospective search of oral melanomas was performed in the archives of the University of Florida Oral and Maxillofacial Pathology Biopsy Service (Gainesville, FL) from 2015 through 2018. Exclusion criteria included cases with inconclusive diagnosis, skin involvement, and missing clinical data or slide material. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02782391193034
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http://dx.doi.org/10.1016/j.joms.2019.03.018DOI Listing
March 2019
1 Read

Association of Anti-Programmed Cell Death 1 Cutaneous Toxic Effects With Outcomes in Patients With Advanced Melanoma.

JAMA Oncol 2019 Apr 18. Epub 2019 Apr 18.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1001/jamaoncol.2019.0046DOI Listing

A randomised controlled trial evaluating the effectiveness of Facebook compared to leaflets in raising awareness of melanoma and harmful sun-related behaviour among young adults.

Eur J Cancer Prev 2019 Apr 16. Epub 2019 Apr 16.

Imperial College of Science, Technology and Medicine, Imperial College Business School, London, UK.

This study describes a randomised control trial investigating whether printed leaflets or social media are more effective in increasing knowledge of the risks of sun exposure and melanoma in people aged 18-29. The study participants were 18-29-year-old university students or graduates, recruited in London. A baseline level of knowledge was measured using the Skin Cancer and Sun Knowledge questionnaire. Read More

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http://dx.doi.org/10.1097/CEJ.0000000000000519DOI Listing

Erythema multiforme-like rash upon anti-melanoma therapy with BRAF and MEK inhibitors.

Eur J Dermatol 2019 Feb;29(1):107-108

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1684/ejd.2019.3511DOI Listing
February 2019

[Exploration of the Role of Tumor Suppressor Genes Foxo1 and PTEN in the Tumorigenesis of Mouse Natural Killer-Cell Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):439-444

Clinical College of 307 Hospital, PLA, Anhui Medical University; Hefei 230032, Anhui Province, China,Department of Lymphoma, General Hospital of PLA Fifth Medical Center, Beijing 100071,

Objective: To explore whether tumor suppressor gene Foxo1 and PTEN play a critical role in the tumorigenesis of mouse natural killer-cell lymphoma.

Methods: NKp46-iCre mice were crossed with mice carrying floxed Foxo1 alleles (Foxo1) as well as floxed PTEN alleles (PTEN) to generate mice in which Foxo1 and PTEN in NK cells were knock-out, referred as Foxo1PTEN. The growth and development of the mice and tumor formation were observed. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.021DOI Listing
April 2019
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Anthecotulide Sesquiterpene Lactone Exhibits Selective Anticancer Effects in Human Malignant Melanoma Cells by Activating Apoptotic and Autophagic Pathways, S-Phase Cell Cycle Arrest, Caspase Activation, and Inhibition of NF-κB Signalling Pathway.

Med Sci Monit 2019 Apr 18;25:2852-2858. Epub 2019 Apr 18.

Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China (mainland).

BACKGROUND We examined the anticancer potential of anthecotulide against SK-MEL-24 malignant melanoma cells. The apoptotic and autophagic effects of anthecotulide were also investigated. MATERIAL AND METHODS The cell viability of SK-MEL-24 human malignant melanoma cells was evaluated by WST-1 assay. Read More

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http://dx.doi.org/10.12659/MSM.913771DOI Listing

Vision loss with pembrolizumab treatment: A report of two cases.

J Oncol Pharm Pract 2019 Apr 18:1078155219841683. Epub 2019 Apr 18.

University of Kansas Medical Center, Kansas City, KS.

Background: Vision loss and other ocular toxicities are rare, but detrimental, side effects of immune checkpoint inhibitors. Herein, we report two patients who developed vision loss while on pembrolizumab treatment.

Cases Presentation: Case 1 - A 58-year-old man was started on pembrolizumab for advanced melanoma. Read More

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http://dx.doi.org/10.1177/1078155219841683DOI Listing
April 2019
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Senescence as a main mechanism of Ritonavir and Ritonavir-NO action against melanoma.

Mol Carcinog 2019 Apr 17. Epub 2019 Apr 17.

Department of Immunology, Institute for Biological Research "Siniša Stanković", Belgrade University, Belgrade, Serbia.

The main focus of this study is exploring the effect and mechanism of two HIV-protease inhibitors: Ritonavir and Ritonavir-nitric oxide (Ritonavir-NO) on in vitro growth of melanoma cell lines. NO modification significantly improved the antitumor potential of Ritonavir, as the IC values of Ritonavir-NO were approximately two times lower than IC values of the parental compound. Our results showed for the first time, that both compounds induced senescence in primary and metastatic melanoma cell lines. Read More

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http://dx.doi.org/10.1002/mc.23020DOI Listing
April 2019
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Key dermoscopic signs in the diagnosis and progression of extrafacial lentigo maligna: Evaluation of a series of 41 cases.

Australas J Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Dermatology Service, Hospital Fundación de Alcorcón, Madrid, Spain.

Background/objectives: Lentigo maligna is usually located on the face. Extrafacial lentigo maligna is less common, and diagnosis of early forms is very difficult. Confocal microscopy of facial and extrafacial lentigo maligna shares the same features (abundant dendritic cells and generalised atypical junctional thickenings) and helps us to identify the dermoscopic features of extrafacial lentigo maligna. Read More

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http://dx.doi.org/10.1111/ajd.13051DOI Listing

NAV2 facilitates invasion of cutaneous melanoma cells by targeting SNAI2 through the GSK-3β/β-catenin pathway.

Arch Dermatol Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Previous studies have identified neuron navigator 2(NAV2) as an oncogene in several human tumors. However, the NAV2 gene expression changes and its role in the pathogenesis of cutaneous melanoma have not been clearly illustrated. Further investigations of NAV2 in cutaneous melanoma may provide new mechanistic insight and treatment strategy for this disease. Read More

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http://dx.doi.org/10.1007/s00403-019-01909-wDOI Listing

BRAF mutation status might contribute an effect on both disease-free and overall survival in stage III cutaneous melanomas treated with intermediate dose interferon-alpha.

Cancer Chemother Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Oncology, Institute of Oncology, University of Istanbul, Capa, 34390, Istanbul, Turkey.

Purpose: The interaction between interferon treatment and BRAF mutation status among melanoma patients have yet to be evaluated. The present study aims to assess the intermediate dose interferon (IDI) in stage III melanoma patients with respect to BRAF mutation status.

Methods: A total of 46 adult lymph node-positive primary skin melanoma patients (23 BRAF-mutant and 23 BRAF-wild) with available information on the mutational status of the oncogene BRAF V600E were included in the analysis. Read More

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http://dx.doi.org/10.1007/s00280-019-03842-1DOI Listing

Pediatric melanoma-The whole (conflicts of interest) story.

Int J Womens Dermatol 2019 Jun 19;5(2):110-115. Epub 2018 Nov 19.

University of Connecticut Health Center, Farmington, Connecticut.

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http://dx.doi.org/10.1016/j.ijwd.2018.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451736PMC

Metastatic melanoma vs lymphoma. Using a sentinel lymph node biopsy a diagnostic tool.

J Surg Case Rep 2019 Apr 12;2019(4):rjz117. Epub 2019 Apr 12.

Plastic Surgery Department, Queen Elizabeth Hospital of Birmingham, Mindelsohn Way, Birmingham, West Midlands B15 2TH, UK.

Sentinel lymph node biopsy (SLNB) is a prognostic tool used in cases of melanoma with a stage IB or greater and the absence of clinical lymphadenopathy. A positive SLNB historically indicated a need for regional lymph node clearance. However, cases of clinical lymphadenopathy in the presence of primary melanoma negates the use of SLNB and rather the British Association of Dermatologists advocate a primary block dissection of regional lymphatic tissue [NICE UK. Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjz11
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http://dx.doi.org/10.1093/jscr/rjz117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460898PMC
April 2019
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Synchronous non-collision melanoma and basal cell carcinoma arising from chronic lymphedema: a case report and review of literature.

J Surg Case Rep 2019 Apr 12;2019(4):rjz105. Epub 2019 Apr 12.

Department of General Surgery, Brandon Regional Hospital, Brandon, FL 33511, USA.

Chronic lymphedema (CL) due to failure of lymphatic drainage harbors an immunologically vulnerable environment for the development of various neoplasms. Independently, either melanoma or basal cell carcinoma (BCC) arising from CL has only been reported, but synchronous melanoma and BCC originating from CL is never reported. We report a very rare case of synchronous melanoma and BCC arising from the lymphedematous upper extremity developed secondary to axillary lymphadenectomy for breast cancer. Read More

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http://dx.doi.org/10.1093/jscr/rjz105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460899PMC
April 2019
1 Read

A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA.

Chem Sci 2019 Mar 18;10(12):3502-3513. Epub 2019 Feb 18.

Department of Chemistry , University of Sheffield , Brook Hill , Sheffield , S3 7HF , UK . Email: ; Tel: +44 (0)114 222 9325.

With the aim of developing a sensitizer for photodynamic therapy, a previously reported luminescent dinuclear complex that functions as a DNA probe in live cells was modified to produce a new iso-structural derivative containing Ru(TAP) fragments (TAP = 1,4,5,8-tetraazaphenanthrene). The structure of the new complex has been confirmed by a variety of techniques including single crystal X-ray analysis. Unlike its parent, the new complex displays Ru → L-based MLCT emission in both MeCN and water. Read More

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http://dx.doi.org/10.1039/c8sc05084hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430095PMC

Metal-free alkene carbooxygenation following tandem intramolecular alkoxylation/Claisen rearrangement: stereocontrolled access to bridged [4.2.1] lactones.

Chem Sci 2019 Mar 24;10(10):3123-3129. Epub 2019 Jan 24.

State Key Laboratory of Physical Chemistry of Solid Surfaces , Key Laboratory for Chemical Biology of Fujian Province , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China . Email:

Alkene carbooxygenation has attracted considerable attention over the past few decades as this approach provides an efficient access to various oxygen-containing molecules, especially the valuable O-heterocycles. However, examples of catalytic alkene carbooxygenation a direct C-O cleavage are quite scarce, and the C-O cleavage in these cases is invariably initiated by transition metal-catalyzed oxidative addition. We report here a novel Brønsted acid-catalyzed intramolecular alkoxylation-initiated tandem sequence, which represents the first metal-free intramolecular alkoxylation/Claisen rearrangement. Read More

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http://dx.doi.org/10.1039/c9sc00079hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429610PMC

Identification of the 2-Benzoxazol-2-yl-phenol Scaffold as New Hit for JMJD3 Inhibition.

ACS Med Chem Lett 2019 Apr 25;10(4):601-605. Epub 2019 Feb 25.

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, I-84084 Fisciano, Salerno, Italy.

JMJD3 is a member of the KDM6 subfamily and catalyzes the demethylation of lysine 27 on histone H3 (H3K27). This protein was identified as a useful tool in understanding the role of epigenetics in inflammatory conditions and in cancer as well. Guided by a virtual fragment screening approach, we identified the benzoxazole scaffold as a new hit suitable for the development of tighter JMJD3 inhibitors. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466828PMC

IL17A Blockade Successfully Treated Psoriasiform Dermatologic Toxicity from Immunotherapy.

Cancer Immunol Res 2019 Apr 17. Epub 2019 Apr 17.

Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center

Dermatologic toxicities are the most common immune-related adverse events (irAEs) secondary to immune checkpoint inhibitors (ICI). Front-line treatment for grade 3 or 4 skin irAEs is high-dose corticosteroids, which have their own side effects. Prolonged treatment with corticosteroids may abrogate antitumor ICI activity. Read More

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0682DOI Listing

Sicca Syndrome Associated with Immune Checkpoint Inhibitor Therapy.

Oncologist 2019 Apr 17. Epub 2019 Apr 17.

Sjögren's Syndrome and Salivary Gland Dysfunction Unit, National Institutes of Health, Baltimore, Maryland, USA.

Background: The objective of this study was to characterize the clinicopathologic features of sicca syndrome associated with immune checkpoint inhibitor (ICI) therapy.

Subjects, Materials, And Methods: Consecutive patients with new or worsening xerostomia in the setting of ICI treatment for benign or malignant neoplastic disease were evaluated, including labial salivary gland biopsy (LSGB).

Results: Twenty patients (14 male; median age 57 years) had metastatic melanoma ( = 10), metastatic carcinoma ( = 6), or recurrent respiratory papillomatosis ( = 4) and were being treated with avelumab ( = 8), nivolumab ( = 5), pembrolizumab ( = 4), nivolumab/ipilimumab ( = 2), and M7824, a biologic targeting programmed cell death ligand 1 (PD-L1) and transforming growth factor ß ( = 1). Read More

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2018-0823DOI Listing
April 2019
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Hepatic Injury Induced by a Single Dose of Nivolumab - a Case Report and Literature Review.

Klin Onkol 2019 ;32(2):133-138

Background: The use of nivolumab in the treatment of metastatic melanoma has become well established during past years. Despite its undeniable efficacy, immune-related side effects may occur, including acute liver injury. Liver toxicity caused by nivolumab is usually observed as liver enzyme elevation with mild or no symptoms; further, there is limited information regarding any histopathological findings. Read More

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https://www.linkos.cz/english-summary/klinicka-onkologie-jou
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http://dx.doi.org/10.14735/amko2019133DOI Listing
January 2019
1 Read