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    115138 results match your criteria Malignant Melanoma

    1 OF 2303

    Development of Bell's Palsy After Treatment With Ipilimumab and Nivolumab for Metastatic Melanoma: A Case Report.
    J Immunother 2017 Sep 18. Epub 2017 Sep 18.
    *Department of Pharmacy †Division of Hematology/Oncology, Tisch Cancer Institute, One Gustave L. Levy Place, New York, NY.
    Ipilimumab is a human monoclonal antibody that targets cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), and it is FDA approved for the treatment of unresectable or metastatic melanoma. Immune-related adverse events (irAEs) of gastrointestinal, dermatologic, and endocrine origin are commonly seen, ranging between 18% and 44%, with immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1/PD-L1). Rare irAEs include neurological, renal, and hematologic toxicities. Read More

    [Choroidal Melanoma].
    Acta Med Port 2017 Aug 31;30(7-8):573-577. Epub 2017 Aug 31.
    Serviço de Oftalmologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.
    Choroidal melanoma is the most common primary intraocular malignant tumor in adults. None of the different treatments available offers advantages of survival, resorting more and more to conservative treatments such as brachytherapy, which has been available in Portugal since 2013. In this article we review the clinical characteristics, risk factors, diagnosis, complementary exams and therapeutic options in choroidal melanoma. Read More

    Decreasing incidence of cancer after liver transplantation - A Nordic population-based study over three decades.
    Am J Transplant 2017 Sep 19. Epub 2017 Sep 19.
    Transplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki, Finland.
    Cancer remains one of the most serious long-term complications after liver transplantation (LT). Data for all adult LT patients between 1982 and 2013 was extracted from the Nordic Liver Transplant Registry. Through linkage with respective national cancer-registry data, we calculated standardized incidence ratios (SIRs) based on country, sex, calendar time, and age-specific incidence rates. Read More

    A slow-cycling subpopulation of melanoma cells with highly invasive properties.
    Oncogene 2017 Sep 18. Epub 2017 Sep 18.
    Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA.
    Melanoma is a heterogeneous tumor with different subpopulations showing different proliferation rates. Slow-cycling cells were previously identified in melanoma, but not fully biologically characterized. Using the label-retention method, we identified a subpopulation of slow-cycling cells, defined as label-retaining cells (LRC), with strong invasive properties. Read More

    Alterations of microRNAs throughout the malignant evolution of cutaneous squamous cell carcinoma: the role of miR-497 in epithelial to mesenchymal transition of keratinocytes.
    Oncogene 2017 Sep 18. Epub 2017 Sep 18.
    Laboratory of Molecular Cell Biology, Center for Cancer Research and Department of Medicine C, Sheba Medical Center, Tel Hashomer, Israel.
    Skin carcinogenesis is known to be a multi-step process with several stages along its malignant evolution. We hypothesized that transformation of normal epidermis to cutaneous squamous cell carcinoma (cSCC) is causally linked to alterations in microRNAs (miRNA) expression. For this end we decided to evaluate their alterations in the pathologic states ending in cSCC. Read More

    Psycho-Oncology: A Patient's View.
    Recent Results Cancer Res 2018 ;210:57-66
    Centre Emile Berhneim, Solvay Brussels School of Economics and Management, Université Libre de Bruxelles, Brussels, Belgium.
    Culturally the most important, valued, and less stigmatized part of cancer care is the medical part: The surgeon cutting the tumors out and the oncologist leading the strategic decision-making of the medical treatments available. The least valued and stigmatized part of cancer remains the psychosocial care. This chapter describes-through the eyes of an academic, psychologist, stage IV melanoma patient, and patient advocate-how one patient navigated changing psycho-oncological needs from early stage-to-stage IV through a whole range of psychological interventions available. Read More

    Cutaneous malignant melanoma incidences analyzed worldwide by sex, age, and skin type over personal Ultraviolet-B dose shows no role for sunburn but implies one for Vitamin D3.
    Dermatoendocrinol 2017 14;9(1):e1267077. Epub 2016 Dec 14.
    Marquette University, Department of Mathematics, Statistics, and Computer Science, Milwaukee, WI, USA.
    Because the incidence of cutaneous malignant melanoma (CMM) was reported to increase with increasing terrestrial UVR (290-400 nm) doses in the US back in 1975 and a recent publication showed no association exists with UVR exposure at all, we set out to fully elucidate the role of UVR in CMM. To achieve this goal, we analyzed the CMM incidences over latitude and estimated the average personal UVR dose in the US and numerous countries (> 50) on 5 continents around the world. Using data from the International Agency for Research on Cancer in 2005, we performed worldwide analysis of CMM over UVR dose by sex, age group (0-14, 15-29, 30-49, 50-69, 70-85+) and Fitzpatrick skin types I-VI. Read More

    Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response.
    Sci Rep 2017 Sep 18;7(1):11746. Epub 2017 Sep 18.
    Tumour Immunology, St. Anna Kinderkrebsforschung, Children's Cancer Research Institute, Vienna, Austria.
    Maintaining dendritic cells (DC) in a state of dysfunction represents a key mechanism by which tumour cells evade recognition and elimination by the immune system. Limited knowledge about the intracellular mediators of DC dysfunction restricts success of therapies aimed at reactivating a DC-driven anti-tumour immune response. Using a cell type-specific murine knock-out model, we have identified MAPK-activated protein kinase 2 (MK2) as a major guardian of a suppressive DC phenotype in the melanoma tumour microenvironment. Read More

    DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders.
    Sci Rep 2017 Sep 18;7(1):11762. Epub 2017 Sep 18.
    Cancer Epigenetics Group; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.
    This work provides a comprehensive CpG methylation landscape of the different layers of the human eye that unveils the gene networks associated with their biological functions and how these are disrupted in common visual disorders. Herein, we firstly determined the role of CpG methylation in the regulation of ocular tissue-specification and described hypermethylation of retinal transcription factors (i.e. Read More

    Endothelial Rab7 GTPase Mediates Tumor Growth and Metastasis in Lysosomal Acid Lipase Deficient Mice.
    J Biol Chem 2017 Sep 18. Epub 2017 Sep 18.
    Indiana University School of Medicine, United States
    Tumors depend on their microenvironment for sustained growth, invasion and metastasis. In this environment, endothelial cells (ECs) are an important stromal cell type interacting with malignant cells to facilitate tumor angiogenesis and cancer cell extravasation. Of note, lysosomal acid lipase (LAL) deficiency facilitates melanoma growth and metastasis. Read More

    MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation.
    Biol Open 2017 Sep 18. Epub 2017 Sep 18.
    Manchester Academic Health Science Centre, Division of Extracellular Matrix and Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, UK
    Cell polarity has a fundamental role in shaping the morphology of cells and growing tissues. Polarity is commonly thought to be established in response to extracellular signals. Here we used a minimal in vitro assay that enabled us to monitor the determination of cell polarity in myogenic and chondrogenic differentiation in the absence of external signalling gradients. Read More

    Exploiting drug addiction mechanisms to select against MAPKi-resistant melanoma.
    Cancer Discov 2017 Sep 18. Epub 2017 Sep 18.
    Division of Dermatology, Department of Medicine, University of California, Los Angeles
    Melanoma resistant to MAPK inhibitor(s) (MAPKi) displays loss-of-fitness upon experimental MAPKi withdrawal and, clinically, may be re-sensitized to MAPKi therapy after a drug holiday. Here, we uncovered and therapeutically exploited the mechanisms of MAPKi-addiction in MAPKi-resistant MUTBRAF or MUTNRAS melanoma. MAPKi-addiction phenotypes evident upon drug-withdrawal spanned transient cell-cycle slow-down to cell-death responses, the latter of which required a robust p-ERK rebound. Read More

    Update on the Safety of Phosphodiesterase Type 5 Inhibitors for the Treatment of Erectile Dysfunction.
    Sex Med Rev 2017 Sep 8. Epub 2017 Sep 8.
    Division of Urology, University of Buenos Aires, Buenos Aires, Argentina.
    Introduction: Phosphodiesterase type 5 inhibitors (PDE5Is) have demonstrated efficacy in the treatment of erectile dysfunction (ED). Although historically found to have limited drug-related adverse events, emerging data have suggested that PDE5Is might be associated with melanoma or recurrence of prostate cancer after radical prostatectomy.

    Aim: To summarize the literature on the safety of PDE5Is. Read More

    Cardiac melanoma: Retrospective review of a rare disease at the Mayo clinic (1988-2015).
    Int J Cardiol 2017 Sep 6. Epub 2017 Sep 6.
    Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA. Electronic address:
    Background: Melanoma metastasizing to the heart (cardiac melanoma) is a rare entity that has been described only in autopsy studies or isolated pre-mortem case reports. We aim to better characterize cardiac melanoma, and describe its presenting features, imaging findings, and disease course with a case series collected over nearly 30years.

    Methods: We performed a retrospective review of all patients diagnosed with cardiac melanoma at the Mayo Clinic from 1988 to 2015. Read More

    Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients.
    Neoplasia 2017 Sep 14;19(10):848-855. Epub 2017 Sep 14.
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX.
    This is the first prospective study of the effects of human gut microbiota and metabolites on immune checkpoint inhibitor (ICT) response in metastatic melanoma patients. Whereas many melanoma patients exhibit profound response to ICT, there are fewer options for patients failing ICT-particularly with BRAF-wild-type disease. In preclinical studies, specific gut microbiota promotes regression of melanoma in mice. Read More

    MITF suppression improves the sensitivity of melanoma cells to a BRAF inhibitor.
    Cancer Lett 2017 Sep 15. Epub 2017 Sep 15.
    Research Division, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
    Microphthalmia-associated transcription factor (MITF) is expressed in melanomas and has a critical role in melanocyte development and transformation. Because inhibition of MITF inhibits cell growth in melanoma, MITF is a potential therapeutic target molecule. Here, we report the identification of CH6868398, which has a novel chemical structure and suppresses MITF expression at the protein level in melanoma cells. Read More

    Up-regulation of Rho-associated kinase 1/2 by glucocorticoids promotes migration, invasion and metastasis of melanoma.
    Cancer Lett 2017 Sep 15. Epub 2017 Sep 15.
    Department of Pathophysiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People's Republic of China. Electronic address:
    Although glucocorticoids (GCs) regulate proliferation, differentiation and apoptosis of tumor cells, their influence on metastasis of tumor cells is poorly understood. Melanoma is a type of skin cancers with high metastasis. We investigated the effect of GCs on metastasis of melanoma cells and its mechanism. Read More

    An Update on Randomized Clinical Trials in Melanoma.
    Surg Oncol Clin N Am 2017 Oct;26(4):559-586
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:
    Despite many advances in the treatment of melanoma, it still continues to be a disease that affects many people. Fortunately, there have been a multitude of randomized trials that have refined the treatment of this prevalent disease. From 1975 to 2000, there were 154 prospective randomized trials on the treatment of local, regional, and metastatic melanoma. Read More

    Nivolumab and pembrolizumab: Monoclonal antibodies against programmed cell death-1 (PD-1) that are interchangeable.
    Semin Oncol 2017 Apr 13;44(2):132-135. Epub 2017 Jul 13.
    Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR. Electronic address:
    Nivolumab (Opdivo, Bristol Meyer Squibb, New York, NY) and pembrolizumab (Keytruda, Merck, Kenilworth, NJ) are the first two US Food and Drug Administration (FDA)-approved monoclonal antibodies targeting programmed death-1 (PD-1). Nivolumab and pembrolizumab work by interfering with the interaction between PD-1 and programmed death ligand-1 (PD-L1), whose unimpeded interaction downregulates T cells allowing cancer cells to evade immune surveillance. These drugs have earned a series of FDA approvals for melanoma, non-small cell lung cancer (NSCLC), head and neck squamous cell cancer (HNSCC), urothelial cancer, classical Hodgkin lymphoma, and renal cell cancer. Read More

    In-Flight Ultraviolet Radiation on Commercial Airplanes.
    Aerosp Med Hum Perform 2017 Oct;88(10):947-951
    Introduction: Epidemiological studies suggest that pilots and cabin crew have higher incidences and mortality rates of cutaneous malignant melanoma than those of the general population. Exposure to UV radiation is one of the main risk factors for this type of cancer. The aim of this study was to evaluate the level of UV radiation in an airliner in flight. Read More

    ß-1,3-galactosyl-O-glycosyl-glycoprotein ß-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.
    Oncol Res 2017 Sep 18. Epub 2017 Sep 18.
    Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 251 Shikata-Cho, Kita-Ku, Okayama-Shi, Okayama 700-8558, Japan.
    We previously identified novel S100A8/A9 receptors, Extracellular Matrix Metalloproteinase Inducer (EMMPRIN), MelanomaCell Adhesion Molecule (MCAM), Activated Leukocyte Cell Adhesion Molecule (ALCAM) and Neuroplastin (NPTN) ß, that are critically involved in S100A8/A9-mediated cancer metastasis and inflammation when expressed at high levels. However, little is known about the presence of any cancerspecific mechanism(s) that modifies these receptors, further inducing upregulation at protein levels without any transcriptional regulation. Expression levels of glycosyltransferase-encoding genes were examined by a PCR-based profiling array followed by confirmation with quantitative real time PCR. Read More

    High-dose interleukin-2 (HD IL-2) for advanced melanoma: a single center experience from the University of Pittsburgh Cancer Institute.
    J Immunother Cancer 2017 Sep 19;5(1):74. Epub 2017 Sep 19.
    Department of Melanoma Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Background: Durable remissions are observed in a fraction of metastatic melanoma patients treated with high-dose interleukin-2 (HD IL-2). Early studies reported overall (OR) and complete response (CR) rates of 16% and 8% respectively. Toxicity limited use to specialized centers with standardized protocols. Read More

    Durable response rate as an endpoint in cancer immunotherapy: insights from oncolytic virus clinical trials.
    J Immunother Cancer 2017 Sep 19;5(1):72. Epub 2017 Sep 19.
    MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
    Background: Traditional response criteria may be insufficient to characterize full clinical benefits of anticancer immunotherapies. Consequently, endpoints such as durable response rate (DRR; a continuous response [complete or partial objective response] beginning within 12 months of treatment and lasting ≥6 months) have been employed. There has not, however, been validation that DRR correlates with other more traditional endpoints of clinical benefit such as overall survival. Read More

    Relapse-Free Survival as a Surrogate for Overall Survival in the Evaluation of Stage II-III Melanoma Adjuvant Therapy.
    J Natl Cancer Inst 2018 Jan;110(1)
    European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium; Gustave Roussy Cancer Campus Grand Paris, Villejuif, France; The Christie NHS Foundation Trust, Manchester, UK; University of Pittsburgh Cancer Institute and School of Medicine, Pittsburgh, PA; Mayo Clinic Rochester, Rochester, MN; University of Tubingen, Tubingen, Germany; University of Edinburgh, Western General Hospital, Edinburgh, UK; Bristol-Myers Squibb, Wallingford, CT; Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK; Universitas Brawijaya, Malang, Indonesia; IDDI, Louvain-la-Neuve, Belgium.
    Background: We assessed whether relapse-free survival (RFS; time until recurrence/death) is a valid surrogate for overall survival (OS) among resected stage II-III melanoma patients through a meta-analysis of randomized controlled trials.

    Methods: Individual patient data (IPD) on RFS and OS were collected from 5826 patients enrolled in 11 randomized adjuvant trials comparing interferon (IFN) to observation. In addition, IPD from two studies comparing IFN and vaccination in 989 patients were included. Read More

    The role of pleural fluid MAGE RT-nested PCR in the diagnosis of malignant pleural effusion.
    Thorac Cancer 2012 Nov;3(4):320-325
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Korea.
    Background:   Melanoma antigen (MAGE) genes are expressed in tumor cells, the testis and the placenta. The purpose of this prospective study was to investigate the sensitivity, specificity, and accuracy of the carcinoembryonic antigen (CEA), MAGE reverse transcriptase-nested polymerase chain reaction (RT-nested PCR), and cytology of pleural fluid in the diagnosis of malignant pleural effusion.

    Methods:   Patients in whom unilateral pleural effusion was identified on chest radiography from January to December 2009 were included in the study. Read More

    Wound tension and 'closability' with keystone flaps, V-Y flaps and primary closure: a study in fresh-frozen cadavers.
    ANZ J Surg 2017 Sep 18. Epub 2017 Sep 18.
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, New South Wales, Australia.
    Background: Previous publications have implied that the keystone flap provides mechanical benefits compared to primary closure. This has not been objectively demonstrated.

    Methods: Elliptical defects were created in 'fresh-frozen' cadaveric specimens. Read More

    Descemet Membrane Thickening as a Sign for the Diagnosis of Corneal Graft Rejection: An Ex Vivo Study.
    Cornea 2017 Sep 14. Epub 2017 Sep 14.
    Bascom Palmer Eye Institute, University of Miami, Miami, FL.
    Purpose: To disclose, using an ex vivo study, the histopathological mechanism behind in vivo thickening of the endothelium/Descemet membrane complex (En/DM) observed in rejected corneal grafts (RCGs).

    Methods: Descemet membrane (DM), endothelium, and retrocorneal membranes make up the total En/DM thickness. These layers are not differentiable by high-definition optical coherence tomography; therefore, the source of thickening is unclear from an in vivo perspective. Read More

    Dual MAPK / PI3K pathway inhibition with trametinib and GSK2141795 does not yield clinical benefit in metastatic NRAS mutant and wild type melanoma.
    Pigment Cell Melanoma Res 2017 Sep 16. Epub 2017 Sep 16.
    UCSF Melanoma Oncology, 1600 Divisadero Street, San Francisco, CA, 94143.
    Aberrant MAPK and PI3K pathway signaling may drive the malignant phenotype in NRAS mutant and BRAF(WT) NRAS(WT) metastatic melanoma. To target these pathways NRAS mutant and BRAF(WT) NRAS(WT) patients received oral trametinib at 1.5 mg daily and GSK2141795 at 50 mg daily in a 2-cohort Simon 2-stage design. Read More

    [Superbrown beauty : The surface of tanorexia and tanning dependence].
    Hautarzt 2017 Sep 18. Epub 2017 Sep 18.
    Klinik für Dermatologie und Allergologie, Immunonkologisches Zentrum, Schwerpunkt Männermedizin, Vivantes Klinikum Spandau, Akademisches Lehrkrankenhaus der Charité - Universitätsmedizin Berlin, Neue Bergstr. 6, 13585, Berlin, Deutschland.
    Brown skin symbolizes fitness, health, youthfulness and beauty, combined with leisure, activity, and joy of life in the Central European culture. Tanorexia is a tanning dependence that describes the morbid excessive desire for constant skin tanning. Particularly young women are affected. Read More

    The dosage-dependent effect exerted by the NM23-H1/H2 homolog NDK-1 on distal tip cell migration in C. elegans.
    Lab Invest 2017 Sep 18. Epub 2017 Sep 18.
    Department of Biological Anthropology, ELTE Eötvös Loránd University, Budapest, Hungary.
    Abnormal regulation of cell migration and altered rearrangement of the cytoskeleton are fundamental properties of metastatic cells. The first identified metastasis suppressor NM23-H1, which displays nucleoside-diphosphate kinase (NDPK) activity is involved in these processes. NM23-H1 inhibits the migratory and invasive potential of some cancer cells. Read More

    Diagnosis of hyponatremia and increased risk of a subsequent cancer diagnosis: results from a nationwide population-based cohort study.
    Acta Oncol 2017 Sep 18:1-6. Epub 2017 Sep 18.
    a Department of Clinical Epidemiology , Aarhus University Hospital , Aarhus N , Denmark.
    Background: Hyponatremia has recently been associated with subsequent cancer risk. This population-based nationwide study assessed whether the diagnosis of hyponatremia can predict a cancer diagnosis within most common cancers.

    Material And Methods: Using Danish medical registries, we identified 16,220 patients with a first-time diagnosis of hyponatremia, without a cancer diagnosis, from January 2006 through November 2013. Read More

    Cd226(-/-) natural killer cells fail to establish stable contacts with cancer cells and show impaired control of tumor metastasis in vivo.
    Oncoimmunology 2017 5;6(8):e1338994. Epub 2017 Jul 5.
    College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.
    CD226 is an activating receptor expressed on natural killer (NK) cells, CD8(+) T cells, and other immune cells. Upon binding to its ligands expressed on target cells, CD226 activates intracellular signaling that triggers cytokine production and degranulation in NK cells. However, the role of CD226 in contact dynamics between NK and cancer cells has remained unclear. Read More

    First report of clinical responses to immunotherapy in 3 relapsing cases of chordoma after failure of standard therapies.
    Oncoimmunology 2017 21;6(8):e1338235. Epub 2017 Jun 21.
    Department of Oncology, Geneva University Hospital, Geneva, Switzerland.
    Chordoma is a rare tumor of notochordal origin, currently principally treated by surgery and/or irradiation. Here, we describe the clinical outcome of 3 consecutive patients with metastatic and locally advanced chordoma, treated with different immunotherapeutic approaches. All patients presented fast growing tumors and failure of standard therapies. Read More

    MEK inhibition and immune responses in advanced melanoma.
    Oncoimmunology 2017 10;6(8):e1335843. Epub 2017 Aug 10.
    University Hospital Zurich, Department Dermatology, Zürich, Switzerland.
    phase II and III clinical trials demonstrated modest anti- tumor activity of Binimetinib (MEK162) - a potent allosteric inhibitor of MEK1 and MEK2- in patients with advanced NRAS mutant melanoma. The analysis of the NEMO study in NRAS mutated melanoma, has shown that pre-treatment with immunotherapy improved the outcome of binimetinib therapy. We discuss this finding in the context of in vitro and in vivo effects of MEK inhibition on immuno-critical pathways and interactions. Read More

    Immune biomarkers for prognosis and prediction of responses to immune checkpoint blockade in cutaneous melanoma.
    Oncoimmunology 2017 7;6(8):e1299303. Epub 2017 Mar 7.
    Gustave Roussy, Université Paris-Saclay, INSERM U1015, Villejuif, F-94805, France.
    Existing clinical, anatomopathological and molecular biomarkers fail to reliably predict the prognosis of cutaneous melanoma. Biomarkers for determining which patients receive adjuvant therapies are needed. The emergence of new technologies and the discovery of new immune populations with different prognostic values allow the immune network in the tumor to be better understood. Read More

    Toll-like receptors 7 and 8 expression correlates with the expression of immune biomarkers and positively predicts the clinical outcome of patients with melanoma.
    Onco Targets Ther 2017 1;10:4339-4346. Epub 2017 Sep 1.
    Second Clinical Medical College of Southern Medical University, Guangzhou.
    Background: Toll-like receptors (TLRs) play a critical role in cancer, yet the clinical relevance of TLR7/8 expression in melanoma remains unclear. This study aimed to evaluate the prognostic value of TLR7/8 mRNA levels in melanoma and their correlation with immune biomarkers relevant to disease progression.

    Methods: Normalized gene expression and corresponding clinical data of patients with skin cutaneous melanoma were obtained from two public databases: the Cancer Genome Atlas and GSE19234. Read More

    Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors.
    Onco Targets Ther 2017 29;10:4239-4250. Epub 2017 Aug 29.
    Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Magnolia Drive, Tampa, FL, USA.
    Background: Omaveloxolone is a semisynthetic oleanane triterpenoid that potently activates Nrf2 with subsequent antioxidant function. We conducted a first-in-human Phase I clinical trial (NCT02029729) with the primary objectives to determine the appropriate dose for Phase II studies, characterize pharmacokinetic and pharmacodynamic parameters, and assess antitumor activity.

    Methods: Omaveloxolone was administered orally once daily continuously in a 28-day cycle for patients with stage 4 relapsed/refractory melanoma or non-small cell lung cancer. Read More

    Preparation of coffee oil-algae oil-based nanoemulsions and the study of their inhibition effect on UVA-induced skin damage in mice and melanoma cell growth.
    Int J Nanomedicine 2017 5;12:6559-6580. Epub 2017 Sep 5.
    Department of Food Science.
    Coffee grounds, a waste by-product generated after making coffee, contains approximately 15% coffee oil which can be used as a raw material in cosmetics. Algae oil rich in docosahexaenoic acid (DHA) has been demonstrated to possess anticancer and anti-inflammation functions. The objectives of this study were to develop a gas chromatography-mass spectrometry (GC-MS) method for the determination of fatty acids in coffee oil and algae oil and prepare a nanoemulsion for studying its inhibition effect on ultraviolet A-induced skin damage in mice and growth of melanoma cells B16-F10. Read More

    Resveratrol inhibits proliferation, promotes differentiation and melanogenesis in HT-144 melanoma cells through inhibition of MEK/ERK kinase pathway.
    Microb Pathog 2017 Sep 14. Epub 2017 Sep 14.
    Basic Medical College, Basic Medical College of Hebei Medical University, Hebei, China. Electronic address:
    The present study was aimed to investigate the effect of resveratrol on the viability of HT-144 melanoma cells and formation of melanin. MTT assay was used for analysis of cell viability and western blot for determination of phospho-Mek 1/2, phospho-Erk 1/2 (Tyr-204), Mitf, PBG-D and p-CREB-1 expression. MTT assay results showed that treatment of HT-144 cells with various doses of resveratrol led to a concentration dependent inhibition of proliferation. Read More

    The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma cells.
    Biochem Biophys Res Commun 2017 Sep 15. Epub 2017 Sep 15.
    Department of Pathophysiology, Zunyi Medical University, Zunyi, 563000, China. Electronic address:
    Melanoma is the most common primary malignant neoplasm in adults, causing more deaths than any other skin cancer, necessitating the development of new target-based approaches. Current evidence suggests SIRT1, the mammalian nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylase, and nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting NAD(+) biosynthetic enzyme, together comprise a novel systemic regulatory network to play a pivotal role in cell proliferation and apoptosis. Nevertheless, how the regulation of this cofactor interfaces with signal transduction network remains poorly understood in melanoma. Read More

    Molecular characterisation, ontogeny and expression analysis of melanoma differentiation-associated factor 5 (MDA5) from Asian seabass, Lates calcarifer.
    Dev Comp Immunol 2017 Sep 15. Epub 2017 Sep 15.
    ICAR-Central Institute of Fisheries Education (CIFE), Off-Yari Road, Versova, Mumbai 400 061, India. Electronic address:
    MDA5 is the pivotal member of the retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) and is reported to play a crucial role in type I IFN-mediated responses against pathogen-associated molecular patterns (PAMPs), especially nucleic acids. In this study, we have identified and cloned the full-length cDNA sequence of MDA5, which comprises 3398 nucleotides and encodes for a putative protein of 978 AA length, in Asian seabass, Lates calcarifer. From the putative amino acid sequence of AsMDA5, four different conserved domains could be predicted: two N-terminal CARD domains, a DExDc domain, a HELICc domain and a C-terminal RIG-1_C-RD domain. Read More

    [Acutely induced diabetes mellitus in a 63-year-old female after treatment with ipilimumab for metastatic melanoma].
    Ugeskr Laeger 2017 Sep;179(37)
    Immune checkpoint inhibitors have improved survival rate in patients with advanced melanoma, but also have the potential to induce several adverse events. We report on a 63-year-old woman who had advanced melanoma and was admitted with diabetic ketoacidosis, which had occurred upon treatment with ipilimumab. On admission, the C-peptide level was low, and the HbA1c concentration was 50 mmol/l indicating a rapid onset of the disease. Read More

    Anti-Melanogenic Activity and Cytotoxicity of Pistacia vera Hull on Human Melanoma SKMEL-3 Cells.
    Acta Med Iran 2017 Jul;55(7):422-428
    Department of Pharmacology and Physiology, Pasteur Institute, Tehran, Iran.
    Pistacia vera seed is a common food and medicinal seed in Iran. It's hull (outer skin) as a significant byproduct of pistachio, is traditionally used as tonic, sedative and antidiarrheal and has been shown to be a rich source of antioxidants. The aim of the present study is to evaluate the anti-melanogenic activity of the pistachio hulls in order to discover a new alternative herbal agent to treat skin hyperpigmentation disorders. Read More

    The effect of hydrazine derivatives of 3-formylchromones on angiogenic basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanoma cell line WM-115.
    Acta Biochim Pol 2017 7;64(3):585-590. Epub 2017 Sep 7.
    Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland.
    The hydrazine derivatives of benzopyrones remain an unexplored group of chemical compounds. This preliminary study investigates the influence of A-5, CH-3 and K-2 derivatives at concentrations of 1, 10, 100 nM and 1 μM on selected biochemical factors of a melanoma cell line WM-115, with regard to their potential angiogenic properties. The studied compounds were found to influence cell proliferation, as well as total protein, bFGF and FGFR1 concentration. Read More

    Th9 cells promote antitumor immunity via IL-9 and IL-21 and demonstrate atypical cytokine expression in breast cancer.
    Int Immunopharmacol 2017 Sep 14;52:163-167. Epub 2017 Sep 14.
    Breast-Thyroid Surgery Department, Shengli Oilfield Central Hospital, Dongying, Shandong Province, China. Electronic address:
    Breast cancer is a major cause of cancer-related death in women. Antitumor T cell responses play critical therapeutic roles, including direct cytotoxicity mediated by CD8(+) T cells and immunomodulatory roles mediated by CD4(+) T cells. The IL-9-expressing Th9 cells are recently found to present antitumor immunity in melanoma and lung adenocarcinoma. Read More

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