120,169 results match your criteria Malignant Melanoma

ISCEV extended protocol for the photopic On-Off ERG.

Doc Ophthalmol 2018 Jun 22. Epub 2018 Jun 22.

Department of Electrophysiology, Moorfields Eye Hospital, London, UK.

The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the photopic On-Off ERG, and outlines common clinical applications. A light stimulus duration of 150-200 ms is used in the presence of a rod-suppressing background to elicit cone-driven On- and Off-system ERG components. Read More

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Patient-reported treatment-related symptom burden for patients with advanced melanoma in Canada.

Support Care Cancer 2018 Jun 23. Epub 2018 Jun 23.

Pharmerit International, Boston, MA, USA.

Background: Little is known on the impact of emerging treatments for advanced melanoma (stages III and IV) on patients' functioning and well-being. The objective of this study was to describe the patient-reported treatment-related symptom (TRS) burden in advanced melanoma.

Method: Twenty-nine in-depth, qualitative interviews were conducted among adult patients with advanced melanoma in Canada using a semi-structured interview method. Read More

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Giant congenital melanocytic nevus in a Cameroonian child: a case report.

J Med Case Rep 2018 Jun 23;12(1):175. Epub 2018 Jun 23.

Department of Internal Medicine and Sub-specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Background: Giant congenital melanocytic nevus is a very rare condition characterized by a large skin lesion and an increased risk of complications like neurocutaneous melanosis and malignant transformation. Reports of giant congenital melanocytic nevus are scarce in the sub-Saharan African literature and here we present a case of this disease in a Cameroonian adolescent.

Case Presentation: A 12-year-old Cameroonian girl from the "Baka" ethnic group, with no relevant family and medical histories presented with a progressively extensive brownish-black nodular hypertrophic skin lesion of approximately 45 cm, which she had had since she was 2-days old. Read More

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Impact of Dermoscopy and Reflectance Confocal Microscopy on the Histopathologic Diagnosis of Lentigo Maligna/Lentigo Maligna Melanoma.

Am J Dermatopathol 2018 Jun 15. Epub 2018 Jun 15.

Department of Anatomic Pathology, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy.

Background: Equivocal pigmented lesions of the head are usually biopsied to avoid inappropriate treatment. Clinical approach has evolved from simple visual examination to sophisticated techniques for selecting the biopsy sites.

Objective: This study aimed to retrospectively evaluate the efficiency of dermoscopy (DE) and reflectance confocal microscopy (RCM) in sampling a histopathologically representative focus of lentigo maligna/lentigo maligna melanoma. Read More

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Repair of a Complex Marginal Auricular Defect After Lentigo Maligna Melanoma Excision.

Dermatol Surg 2018 Jun 21. Epub 2018 Jun 21.

ENT Department, University Clinic Ulm, Ulm, Germany.

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Treatment of Digital Melanonychia with Atypia.

Plast Reconstr Surg 2018 Jun 20. Epub 2018 Jun 20.

Division of Plastic Surgery, Hand and Upper Extremity Service, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Background: Melanonychia of the digit is uncommon in the Caucasian population and is concerning because of potential malignant transformation. Several histologic changes occur prior to malignant transformation, including melanocytic atypia. The aim of this study was to evaluate patients with melanonychia with melanocytic hyperplasia and determine the risk factors for malignant transformation. Read More

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Elimination of melanoma by sortase A-generated TCR-like antibody-drug conjugates (TL-ADCs) targeting intracellular melanoma antigen MART-1.

Biomaterials 2018 Jun 15;178:158-169. Epub 2018 Jun 15.

Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. Electronic address:

Most tumor-associated proteins are located inside tumor cells and thus are not accessible to current marketed therapeutic monoclonal antibodies or their cytotoxic conjugates. Human leukocyte antigen (HLA) class I can present peptides derived from intracellular tumor-associated proteins and somatically mutated proteins on the cell's surface, forming an HLA/peptide complex as tumor-specific antigens for T cell receptor (TCR) recognition. Therefore, HLA-mediated presentation of intracellular tumor antigen peptides provides a viable way to distinguish tumor cells from normal cells, which is important for broadening antigen selection, especially for antibody-drug conjugates (ADCs) regarding their highly cytotoxic payload. Read More

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Sorafenib in combination with gemcitabine plus cisplatin chemotherapy in metastatic renal collecting duct carcinoma: A prospective, multicentre, single-arm, phase 2 study.

Eur J Cancer 2018 Jun 19;100:1-7. Epub 2018 Jun 19.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing 100142, China. Electronic address:

Background: Collecting duct carcinoma (CDC) is a rare type of renal cancer with a poor prognosis. As there are no standard guidelines for the management of metastatic CDC (mCDC), we evaluated the efficacy and safety of combined therapies of sorafenib, gemcitabine, plus cisplatin in patients with mCDC.

Materials And Methods: A prospective, multicentre, single-arm, open-label, phase 2 trial (ClinicalTrials. Read More

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June 2018
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Immunomodulatory and enhanced antitumor activity of a modified thymosin α1 in melanoma and lung cancer.

Int J Pharm 2018 Jun 19;547(1-2):611-620. Epub 2018 Jun 19.

School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

Tumor-targeted therapy is an attractive strategy for cancer treatment. Peptide hormone thymosin α1 (Tα1) has been used against several diseases, including cancer, but its activity is pleiotropic. Herein, we designed a fusion protein Tα1-iRGD by introducing the tumor homing peptide iRGD to Tα1. Read More

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Time trends in the prevalence of cancer and non-cancer diseases among older U.S. adults: Medicare-based analysis.

Exp Gerontol 2018 Jun 19. Epub 2018 Jun 19.

Biodemography of Aging Research Unit, Center for Population Health and Aging, Duke University, Durham, NC, United States of America.

Longer lifespan is accompanied by a larger number of chronic diseases among older adults. Because of a growing proportion of older adults in the U.S. Read More

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June 2018
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The changing paradigm of management in melanoma brain metastases.

Asia Pac J Clin Oncol 2018 Jun 22. Epub 2018 Jun 22.

Department of Medical Oncology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Aim: Improved systemic treatment has improved the prognosis of metastatic melanoma (MM). However, brain metastases (BMs) are a frequent complication. We aimed to explore the outcome of these patients with modern therapeutic options. Read More

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Immediate versus delayed reconstruction of head and neck cutaneous melanoma.

Laryngoscope 2018 Jun 22. Epub 2018 Jun 22.

Department of Otolaryngology-Head and Neck Surgery, University of Ottawa.

Objective: Controversy exists regarding the surgical management of cutaneous melanoma and the optimal timing of reconstruction. One approach to ensuring an oncologically sound outcome is a two-stage procedure, with reconstruction delayed for negative permanent section margins. Alternatively, a single-stage excision with immediate reconstruction is advantageous because it limits both resource use and patient morbidity from multiple procedures. Read More

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Treating melanoma in situ and lentigo maligna with Mohs micrographic surgery in Australia.

Australas J Dermatol 2018 Jun 22. Epub 2018 Jun 22.

South Perth Specialist Skin Cancer Centre, Perth, Western Australia, Australia.

Background/objectives: There is a paucity of Australian data on the use of Mohs micrographic surgery for treating melanoma in situ and lentigo maligna. We share an Australian centre's experience with the technique.

Methods: A total of 62 patients with 62 lesions of melanoma in situ and lentigo maligna referred for treatment between 2015 and 2017 comprised the study group. Read More

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A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma.

J Enzyme Inhib Med Chem 2018 Dec;33(1):1089-1094

a Department of Medicinal Chemistry, School of Medicine , Nankai University , Tianjin , China.

Indoleamine 2,3-dioxygenase 1 (IDO1) activity links to immune escape of cancers. Inhibition of IDO1 provides a new approach for cancer treatment. Most clinical IDO1 drugs show marginal efficacy as single agents. Read More

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December 2018

Cold Atmospheric Plasma Induces Apoptosis of Melanoma Cells via Sestrin2-mediated iNOS Signaling.

J Biophotonics 2018 Jun 22:e201800046. Epub 2018 Jun 22.

Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P. R. China.

Cold atmospheric plasma (CAP) represents a promising therapy for selectively cancer killing. However, the mechanism of CAP-induced cancer cell death remains unclear. Here, we identified the tumor necrosis factor (TNF)-family members, especially Fas, and overloaded intracellular nitric oxide (NO) participated in CAP induced apoptosis in A375 and A875 melanoma cell lines, which was known as extrinsic apoptosis pathway. Read More

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Undifferentiated sinonasal malignant melanoma: A case report.

Oncol Lett 2018 Jul 8;16(1):580-584. Epub 2018 May 8.

Department of Pathology, Anhui Provincial Hospital, Hefei, Anhui 230001, P.R. China.

Undifferentiated sinonasal malignant melanoma (MM) is a rare type of tumor, which can be easily misdiagnosed. The present study reports a 41-year-old male patient who presented with a 4-day history of epistaxis. Clinical examination and radiological imaging lead to the detection of a mass in the right sinonasal region. Read More

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Choroidal hematoma presenting as pseudo-uveal melanoma in a monocular 47-year-old Asian Indian lady with opaque media.

Oman J Ophthalmol 2018 May-Aug;11(2):175-177

Department of Vitreoretina, Aditya Birla Sankara Nethralaya, Kolkata, West Bengal, India.

Pseudomelanoma is a condition that mimics a uveal melanoma. Various methods are used to differentiate between uveal melanoma and mimicking conditions, but none is definitive. We report a case of localized hemorrhagic choroidal detachment in monocular middle-aged Asian lady of Indian origin with opaque media secondary to failed corneal graft. Read More

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Distinguishing midzonal iris pigment epithelial cyst from adenoma and ciliary body melanoma.

Oman J Ophthalmol 2018 May-Aug;11(2):161-163

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

A 49-year old male with corrected visual acuity of 20/25 OD and 20/20 OS was found to have an asymptomatic dark iris mass OD with suspicion for ciliary body melanoma. Predilation slit-lamp biomicroscopy revealed a well-circumscribed brown round mass arising posterior to the iris, presumably from the ciliary body; however, postdilation demonstrated an extended fusiform mass of the iris pigment epithelium (IPE). By anterior segment imaging, the well-circumscribed IPE mass was cystic and measured 1440 microns in thickness peripherally predilation and 300 microns in thickness postdilation. Read More

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[Pigmented extramammary Paget's disease accompanied with condyloma acuminatum: a case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Jun;50(3):572-575

Department of Dermatology, Peking University People's Hospital, Beijing 100044, China.

Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease, characterized as a superficial pigmented scaly macule clinically and an increased number of melanocytes scattered between the Paget's cells histologically. So it may be confused clinically and histologically with melanocytic tumors, dermatitis and other dermatoses. Different therapeutic attitudes are required in this case of adenocarcinoma in situ as opposed to melanoma and dermatitis. Read More

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Is imaging of the brain necessary at diagnosis for cutaneous head and neck melanomas?

Am J Otolaryngol 2018 Jun 8. Epub 2018 Jun 8.

Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, United States.

Objective: To evaluate the frequency of brain metastasis at the time of diagnosis for patients with cutaneous head and neck melanoma (CHNM).

Methods: Patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 2010 to 2014 based on a diagnosis of CHNM using ICD O-3 histology codes and primary site location documentation. Patients were also included if they had a "yes" or "no" documented in the "Mets at Dx-Brain" category. Read More

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Therapeutic Silencing of miR-214 Inhibits Tumor Progression in Multiple Mouse Models.

Mol Ther 2018 Jun 18. Epub 2018 Jun 18.

Molecular Biotechnology Center (MBC), University of Torino, Torino, Italy; Department Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy; Center for Complex Systems in Molecular Biology and Medicine, University of Torino, Torino, Italy. Electronic address:

We previously demonstrated that miR-214 is upregulated in malignant melanomas and triple-negative breast tumors and promotes metastatic dissemination by affecting a complex pathway including the anti-metastatic miR-148b. Importantly, tumor dissemination could be reduced by blocking miR-214 function or increasing miR-148b expression or by simultaneous interventions. Based on this evidence, with the intent to explore the role of miR-214 as a target for therapy, we evaluated the capability of new chemically modified anti-miR-214, R97/R98, to inhibit miR-214 coordinated metastatic traits. Read More

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Tumor mitotic rate is an independent predictor of survival for nonmetastatic melanoma.

Surgery 2018 Jun 18. Epub 2018 Jun 18.

Division of Surgical Oncology, Tufts University School of Medicine-Maine Medical Center, Portland. Electronic address:

Background: Tumor mitotic rate is a known prognostic variable in Stage I melanoma; however, its importance is unclear in Stages II and III.

Methods: Patients diagnosed with nonmetastatic cutaneous melanoma from 2010 to 2014 were identified from the National Cancer Institute's Surveillance, Epidemiology, and End Results registry.

Results: Of a total of 71,235 patients, the majority were white (94. Read More

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June 2018
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Malignancy development risk in psoriatic arthritis patients undergoing treatment: A systematic review and meta-analysis.

Semin Arthritis Rheum 2018 May 23. Epub 2018 May 23.

Departments of Rheumatology and Clinical Immunology Center, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, #41 Damucang xidan, Beijing, China.

Background: Psoriatic arthritis (PsA) is a chronic and seronegative inflammatory arthritis occurring in patients with psoriasis. The current knowledge about the risk of malignancy associated with psoriatic arthritis (PsA) patients undergoing therapy is controversial. We focused on the relationship between malignancy and therapy and undertook a meta-analysis to address this issue. Read More

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Differential expression of ABCB5 in BRAF inhibitor-resistant melanoma cell lines.

BMC Cancer 2018 Jun 22;18(1):675. Epub 2018 Jun 22.

The Hiram C. Polk, Jr MD Department of Surgery, University of Louisville School of Medicine, Louisville, KY, 40292, USA.

Background: More than 50% of metastatic melanoma patients have a specific mutation in the serine/threonine kinase BRAF. This results in constitutive activation of the RAS-RAF-MEK-ERK-MAP kinase pathway, which causes uncontrolled cell growth. Vemurafenib (PLX4032) is an oral chemotherapeutic agent that targets the specific mutation V600E in the BRAF protein. Read More

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Metformin Reduces TRIB3 Expression and Restores Autophagy Flux: An Alternative Antitumor Action.

Autophagy 2018 Jun 21. Epub 2018 Jun 21.

a Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica; Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , 100050 , China.

Deregulation of metabolism during melanoma progression is tightly associated with the genetic and epigenetic alterations of metabolic regulators. Metformin, a macroautophagy/autophagy inducer, has beneficial effects of preventing and treating multiple cancers with an unclear mechanism. Enhanced pseudokinase TRIB3 was reported to link metabolic stressors to melanoma promotion by inhibiting autophagy and ubiquitin-proteasome degradation systems. Read More

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Management of Patients With Skin Cancers: Basal Cell Carcinoma and Melanoma.

J Adv Pract Oncol 2017 Apr 1;8(3):244-248. Epub 2017 Apr 1.

SUNY Downstate Medical Center, Brooklyn, New York.

Novel therapies are changing the treatment paradigm for both melanoma and advanced/metastatic basal cell carcinoma. While immunotherapies are increasing survival benefits in melanoma, they are associated with unique immune-related adverse events. Read More

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[Silencing of PKG1 expression enhances the efficacy of vemurafenib against melanoma cell].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2017 Apr;33(4):289-293

Department of Physiology, Cell Physiology Key Laboratory of Shanxi Province, Shanxi Medical University, Taiyuan 030001, China.

Objective: To explore whether targeting phosphoglycerate kinase 1 (PGK1) can enhance the sensitivity of BRAF mutation melanoma cells to vemurafenib.

Methods: The methods of cell biology, molecular biology and pharmacology(MTT assay, Western blot, FCM, Colongenic assay) were used in this study.

Results: ① Silencing of PGK1 expression increased the efficacy of vemurafenib in melanoma cells, as evidenced by greater killing in the tumor cells subjected to combined treatment of vemurafenib with siPGK1; ②The mechanism of enhanced sensitivity of melanoma cells to vemurafenib was associated with activation of apoptotic signaling pathway. Read More

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Mechanisms of antimelanoma effect of oat β-glucan supported by electroporation.

Bioelectrochemistry 2018 Jun 6;123:255-259. Epub 2018 Jun 6.

Department of Medical Biochemistry, Wroclaw Medical University, Chalubinskiego 10, 50-368 Wroclaw, Poland; Department of Molecular and Cellular Biology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland. Electronic address:

There are still not specified mechanisms how beta-glucan molecules are transported into cells. Supposing, beta-glucan toxicity against tumor cells may be related to the overexpression of the transporter responsible for the transport of glucose molecules in the cells. In this case, glucans - polymers composed of glucose units are much more up-taken by tumor than normal cells. Read More

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Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer.

Cancer Lett 2018 Jun 18. Epub 2018 Jun 18.

AntiCancer, Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USA. Electronic address:

Recombinant methioninase (rMETase) was administered as an injectable drug to target methionine dependence of cancer. Recently, we observed that rMETase could be administered orally (o-rMETase) in a patient-derived orthotopic xenograft (PDOX) mouse model of melanoma. Here, we determined the efficacy of o-rMETase on a pancreatic cancer PDOX model. Read More

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CD73 expression and clinical significance in human metastatic melanoma.

Oncotarget 2018 Jun 1;9(42):26659-26669. Epub 2018 Jun 1.

Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Background: CD73 is an ectoenzyme involved in the production of adenosine. It exerts immunosuppressive and protumoral roles and has emerged as a potential immuno-oncology target.

Results: CD73 expression was detected in TC in 54% of melanoma metastases, involving < 50% TC in the majority of the cases, with variable intensity. Read More

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Anticancer effects of combinational treatment with BRAF siRNA and PI3K pathway inhibitors in melanoma cell lines harboring BRAF.

Oncol Lett 2018 Jul 2;16(1):632-642. Epub 2018 May 2.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, P.R. China.

In the present study, the anti-tumor effects of combination treatment with an siRNA targeting B-Raf proto-oncogene serine/threonine kinase (BRAF) and phosphoinositide 3-kinase (PI3K) signaling pathway inhibitors was investigated in melanoma cell lines harboring BRAF. Human melanoma A375 and WM115 cells were treated with siRNA targeting to BRAF or BRAF, combined with treatment with PI3K signaling pathway inhibitors. CCK-8 and EdU proliferation assays were performed to assess cell viability and proliferation, respectively, following treatment. Read More

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Advanced choroidal melanoma with a desirable aesthetic outcome after enucleation: A case report.

Oncol Lett 2018 Jul 8;16(1):511-514. Epub 2018 May 8.

Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71003 Heraklion, Crete, Greece.

Choroidal melanoma is a rare ocular tumor. The present study reports the case of a 66-year-old male who presented with chronic headache and progressive visual loss. Physical eye examination and combined A- and B-mode ultrasonography detected choroidal melanoma. Read More

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Antibody response against cancer-testis antigens MAGEA4 and MAGEA10 in patients with melanoma.

Oncol Lett 2018 Jul 10;16(1):211-218. Epub 2018 May 10.

Institute of Technology, University of Tartu, 50411 Tartu, Estonia.

Melanoma-associated antigen A (MAGEA) represent a class of tumor antigens that are expressed in a variety of malignant tumors, however, their expression in healthy normal tissues is restricted to germ cells of testis, fetal ovary and placenta. The restricted expression and immunogenicity of these antigens make them ideal targets for immunotherapy in human cancer. In the present study the presence of naturally occurring antibodies against two MAGEA subfamily proteins, MAGEA4 and MAGEA10, was analyzed in patients with melanoma at different stages of disease. Read More

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Human αβ and γδ T Cells in Skin Immunity and Disease.

Front Immunol 2018 6;9:1304. Epub 2018 Jun 6.

Department of Biological Sciences, California State University of San Marcos, San Marcos, CA, United States.

γδ T lymphocytes maintain skin homeostasis by balancing keratinocyte differentiation and proliferation with the destruction of infected or malignant cells. An imbalance in skin-resident T cell function can aggravate skin-related autoimmune diseases, impede tumor eradication, or disrupt proper wound healing. Much of the published work on human skin T cells attributes T cell function in the skin to αβ T cells, while γδ T cells are an often overlooked participant. Read More

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Identification of CD24 as a marker for tumorigenesis of melanoma.

Onco Targets Ther 2018 12;11:3401-3406. Epub 2018 Jun 12.

Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China.

Objective: Cutaneous melanoma (CM) is a common skin cancer. Surgery is still the primary treatment for CM, as melanoma is resistant to chemotherapy. In the recent years, it has been found that cancer stem-like cells (CSCs) are responsible for this drug resistance. Read More

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'Minimalist' Nanovaccine Constituted from Near Whole Antigen for Cancer Immunotherapy.

ACS Nano 2018 Jun 21. Epub 2018 Jun 21.

One of the major challenges in vaccine design has been the over dependence on incorporation of abundant adjuvants, that in fact is in violation of the 'minimalist' principle. In the present study, a compact nanovaccine derived from a near whole antigen (up to 97 wt%) was developed. The nanovaccine structure was stabilized by free cysteines within each antigen (ovalbumin, OVA) which were tempo-spatially exposed and heat-driven to form extensive intermolecular disulfide network. Read More

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June 2018
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Where are all the women scientists in pigment cell and melanoma research?

Pigment Cell Melanoma Res 2018 Jul;31(4):456

Department of Dermatology, University of Wisconsin-Madison, Madison, WI, USA.

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Nodal pigmentation due to tattoo pigment does not influence survival of melanoma patients.

J Dtsch Dermatol Ges 2018 Jun 21. Epub 2018 Jun 21.

Department of Dermatology, Saarland University Medical Center, Homburg/Saar, Germany.

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Patient acceptance and trust in automated computer-assisted diagnosis of melanoma with dermatofluoroscopy.

J Dtsch Dermatol Ges 2018 Jun 21. Epub 2018 Jun 21.

Department of Dermatology, University Medical Center, Ruprecht Karl University, Heidelberg, Germany.

Background And Objectives: Automated computer-guided diagnostic procedures are increasingly being integrated into patient care. However, in contrast to the increasing application of automation, patient acceptance and trust in such technologies has rarely been studied. Automated diagnosis of melanoma with dermatofluoroscopy was recently approved by regulatory agencies. Read More

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JOURNAL CLUB: Primary Anorectal Melanoma: MRI Findings and Clinicopathologic Correlations.

AJR Am J Roentgenol 2018 Jun 21:W1-W11. Epub 2018 Jun 21.

2 Department of Pathology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Objective: The purpose of this study is to evaluate the MRI features of primary anorectal malignant melanoma and to correlate these features with its clinical and pathologic characteristics.

Materials And Methods: The medical records of 12 patients (five men and seven women; mean age [± SD], 60.8 ± 10. Read More

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June 2018
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Cyclometalated Ruthenium(II) Complexes Derived from α-Oligothiophenes as Highly Selective Cytotoxic or Photocytotoxic Agents.

Inorg Chem 2018 Jun 21. Epub 2018 Jun 21.

Department of Chemistry , Acadia University , Wolfville , Nova Scotia B4P 2R6 , Canada.

The photophysical and photobiological properties of a new class of cyclometalated ruthenium(II) compounds incorporating π-extended benzo[ h]imidazo[4,5- f]quinoline (IBQ) cyclometalating ligands (C^N) bearing thienyl rings ( n = 1-4, compounds 1-4) were investigated. Their octanol-water partition coefficients (log P) were positive and increased with n. Their absorption and emission energies were red-shifted substantially compared to the analogous Ru(II) diimine (N^N) complexes. Read More

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Stereotactic radiosurgery for brain metastases from malignant melanoma and the impact of hemorrhagic metastases.

J Neurooncol 2018 Jun 20. Epub 2018 Jun 20.

Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA.

Introduction: Stereotactic radiosurgery (SRS) is a common treatment modality among patients with brain metastases, particularly from malignant melanoma. Our objective was to investigate the difference in local control, toxicity, and survival among patients with hemorrhagic and solid melanoma brain metastases.

Methods: We collected demographic, treatment, local control, toxicity, and survival for 134 patients with a total of 936 intracranial melanoma metastases who underwent SRS between 1998 and 2015. Read More

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Comparison of targeted next generation sequencing (NGS) versus isolated BRAF V600E analysis in patients with metastatic melanoma.

Virchows Arch 2018 Jun 21. Epub 2018 Jun 21.

Department of Pathology and Laboratory Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Molecular testing on advanced metastatic melanoma is critical for guiding targeted therapy. Traditionally, this analysis has relied on isolated BRAF V600E analysis; however, more recently targeted next generation sequencing (NGS) is being utilized. The clinical utility of BRAF V600E allele-specific PCR and targeted NGS were compared for metastatic melanoma samples sent to UHCMC pathology during a two and half year span. Read More

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Dermoscopy of chondrodermatitis nodularis helicis.

Arch Dermatol Res 2018 Jun 20. Epub 2018 Jun 20.

Department of Dermatology, Central University Hospital of Asturias, Avda. Roma s/n, 33011, Oviedo, Spain.

Chondrodermatitis nodularis helicis (CNH) is a benign auricular disease whose differentiation with nonpigmented tumors is mandatory. Clinical characteristics of CNH are well known, but there is no information about the dermoscopic features that could help differentiate CNH from squamous cell carcinoma and other non-melanoma skin cancers. To describe the dermoscopic appearance of CNH and to formulate a differential diagnostic model, we conducted  a retrospective, single center, observational dermoscopic study on a sample of 189 biopsy-proven lesions: 25 CNH; 26 squamous cell carcinomas; 62 basal cell carcinomas and 76 other benign and malignant tumors. Read More

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Assessment of a Predictive Scoring Model for Dermoscopy of Subungual Melanoma In Situ.

JAMA Dermatol 2018 Jun 20. Epub 2018 Jun 20.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Importance: Subungual melanoma in situ (SMIS) is a malignant neoplasm that requires early diagnosis and complete surgical excision; however, little is known about the usefulness of the detailed dermoscopic features of longitudinal melanonychia (LM) to predict the diagnosis of SMIS.

Objectives: To investigate the characteristic dermoscopic findings of SMIS and to establish a predictive scoring model for the diagnosis of SMIS in patients with adult-onset LM affecting a single digit.

Design, Setting, And Participants: A cohort study of 19 patients with biopsy-proven SMIS and 26 patients with benign LM diagnosed in a tertiary referral hospital in Seoul, South Korea, from September 1, 2013, to July 31, 2017. Read More

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Codon-specific translation reprogramming promotes resistance to targeted therapy.

Nature 2018 Jun 20. Epub 2018 Jun 20.

Laboratory of Cancer Signaling, University of Liège, Liège, Belgium.

Reprogramming of mRNA translation has a key role in cancer development and drug resistance . However, the molecular mechanisms that are involved in this process remain poorly understood. Wobble tRNA modifications are required for specific codon decoding during translation. Read More

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Effect of calcium electroporation on tumour vasculature.

Sci Rep 2018 Jun 20;8(1):9412. Epub 2018 Jun 20.

Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, Ljubljana, Slovenia.

Calcium electroporation (CaEP) is a novel anti-tumour treatment that induces cell death by internalization of large quantities of calcium. The anti-tumour effectiveness of CaEP has been demonstrated in vitro, in vivo, and in preliminary clinical trials; however, its effects on the vasculature have not been previously investigated. Using a dorsal window chamber tumour model, we observed that CaEP affected to the same degree normal and tumour blood vessels in vivo, as it disrupted the vessels and caused tumour eradication by necrosis. Read More

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Use of shared care and routine tests in follow-up after treatment for localised cutaneous melanoma.

BMC Health Serv Res 2018 Jun 20;18(1):477. Epub 2018 Jun 20.

School of Public Health, The University of Sydney, Sydney, NSW, Australia.

Background: Patients may decide to undertake shared care with a general practitioner (GP) during follow-up after treatment for localised melanoma. Routine imaging tests for surveillance may be commonly used despite no evidence of clinical utility. This study describes the frequency of shared care and routine tests during follow-up after treatment for localised melanoma. Read More

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[Anti-tumor effect and impact on tumor immune microenvironment of tumor-targeted Salmonella VNP20009].

Yao Xue Xue Bao 2016 09;51(9):1417-22

Salmonella is a gram-negative bacterium that has an ability of tumor-targeting growth and proliferation. Attenuated Salmonella VNP20009 is a virulence genes-knockout bacterial strain based on Salmonella typhimurium, and it has an advantage of good therapeutic effect and low toxicity. One of the mechanisms of anti-tumor effect of VNP20009 is the induction of inflammatory reaction within tumor tissues. Read More

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September 2016
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