Search our Database of Scientific Publications and Authors

I’m looking for a

    111511 results match your criteria Malignant Melanoma

    1 OF 2231

    The value of reflectance confocal microscopy in diagnosis of flat pigmented facial lesions: a prospective study.
    J Eur Acad Dermatol Venereol 2017 Feb 18. Epub 2017 Feb 18.
    Department of General Dermatology, Medical University of Vienna, Vienna General Hospital (AKH), Vienna, Austria.
    Background: Flat pigmented facial lesions are difficult to diagnose even with dermatoscopy. It is controversial how additional information obtained by in vivo reflectance confocal microscopy (RCM) impacts the diagnosis and management.

    Objective: To examine what in vivo reflectance confocal microscopy of flat pigmented facial lesions adds to clinical examination using dermatoscopy including digital dermatoscopic monitoring. Read More

    Indocyanine green-assisted sentinel lymph node biopsy in melanoma using the "FOVIS" system.
    J Dtsch Dermatol Ges 2017 Feb;15(2):169-178
    Department of Dermatology and Venereology, Otto von Guericke University, Magdeburg, Germany.
    Background: Metastatic involvement of the sentinel lymph node (SLN) represents a key prognostic factor in melanoma. The combined use of a radiocolloid (technetium-99m) and blue dye is the gold standard in sentinel lymph node biopsy (SLNB). In this context, near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) has been suggested as an alternative. Read More

    Clinical course, treatment modalities, and quality of life in patients with congenital melanocytic nevi - data from the German CMN registry.
    J Dtsch Dermatol Ges 2017 Feb;15(2):159-167
    Department of Dermatology, University of Lübeck, Germany.
    Background: Congenital melanocytic nevi (CMN) are associated with mental stress as well as medical risks for those affected. The German CMN registry was initiated in 2005. Herein, we present results from an interim analysis focusing on disease course, treatment modalities, and quality of life. Read More

    Opportunistic autoimmunity secondary to cancer immunotherapy (OASI): An emerging challenge.
    Rev Med Interne 2017 Feb 14. Epub 2017 Feb 14.
    Service de médecine interne, département de médecine interne et infectiologie, hôpital européen de Marseille, 6, rue Désirée-Clary, Marseille, 13003 France.
    With "checkpoint inhibitors" targeting PD1/PD-1-ligands or CTLA-4/CD28 pathways, immunotherapy has profoundly modified therapeutic strategies in oncology. First approved in refractory metastatic neoplasms (melanoma and lung adenocarcinoma), it is now being tested broadly in other cancers and/or as adjuvant treatment. For a significant proportion of patients, immunotherapy is responsible for "immunological" events, identified as Immune-Related Adverse Events (irAEs). Read More

    PD-1 and PD-L1 antibodies in cancer: current status and future directions.
    Cancer Immunol Immunother 2017 Feb 17. Epub 2017 Feb 17.
    Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, 522 First Avenue, 1310 Smilow Research Building, New York, NY, 10016, USA.
    Immunotherapy has moved to the center stage of cancer treatment with the recent success of trials in solid tumors with PD-1/PD-L1 axis blockade. Programmed death-1 or PD-1 is a checkpoint molecule on T cells that plays a vital role in limiting adaptive immune responses and preventing autoimmune and auto-inflammatory reactivity in the normal host. In cancer patients, PD-1 expression is very high on T cells in the tumor microenvironment, and PD-L1, its primary ligand, is variably expressed on tumor cells and antigen-presenting cells within tumors, providing a potent inhibitory influence within the tumor microenvironment. Read More

    Carbon dots based FRET for the detection of DNA damage.
    Biosens Bioelectron 2017 Feb 9;92:133-139. Epub 2017 Feb 9.
    Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, Brno CZ-613 00, Czechia; Central European Institute of Technology, Brno University of Technology, Technicka 3058/10, CZ-616 00 Brno, Czechia. Electronic address:
    Here, we aimed our attention at the synthesis of carbon dots (C-dots) with the ability to interact with DNA to suggest an approach for the detection of DNA damage. Primarily, C-dots modified with amine moieties were synthesized using the one-step microwave pyrolysis of citric acid in the presence of diethylenetriamine. The C-dots showed strong photoluminescence with a quantum yield of 4%. Read More

    Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report.
    Int J Surg Case Rep 2017 Jan 19;32:12-15. Epub 2017 Jan 19.
    Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, 59046, Saudi Arabia. Electronic address:
    Introduction: Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread to the superficial or deep inguinal lymph nodes, thus metastatic involvement of these lymph nodes can easily be overlooked.

    Case Presentation: Here-in we report a case of a 65-year old Saudi morbid obese female, who presented with left inguinal lymphadenopathy as initial delayed site of metastasis almost 19 months after the initial treatment for FIGO IA endometrial carcinoma. Read More

    Inhibition of proliferation and invasion in 2D and 3D models by 2-methoxyestradiol in human melanoma cells.
    Pharmacol Res 2017 Feb 14. Epub 2017 Feb 14.
    Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address:
    Despite the recent advances in the clinical management of melanoma, there remains a need for new pharmacological approaches to treat this cancer. 2-methoxyestradiol (2ME) is a metabolite of estrogen that has shown anti-tumor effects in many cancer types. In this study we show that 2ME treatment leads to growth inhibition in melanoma cells, an effect associated with entry into senescence, decreased pRb and CyclinB1 expression, increased p21/Cip1 expression and G2/M cell cycle arrest. Read More

    S100B is a potential disease activity marker in non-segmental vitiligo.
    J Invest Dermatol 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
    Vitiligo is a chronic skin condition characterized by progressive depigmentation of the skin. S100B is a damage-associated molecular pattern (DAMP) protein expressed in melanocytes, which has been proposed as a marker of melanocyte cytotoxicity. While the use of S100B as a biomarker in melanoma is well established, its association with vitiligo activity has not yet been investigated. Read More

    Peritumoural leukoderma.
    Indian J Dermatol Venereol Leprol 1981 May-Jun;47(3):175-179
    Two patients with multiple, metastatic nodules in the skin are described. One of them was a 52-year old man who had midtarsal amputation of his right foot for 'melanoma' of the s6le. The other was a female patient who presented with multiple cutaneous nodules, which on histology proved to be undifferentiated carcinoma cell deposits. Read More

    The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung.
    Oncotarget 2017 Feb 15. Epub 2017 Feb 15.
    Uppsala University, Department of Medical Biochemistry and Microbiology, Uppsala, Sweden.
    Mast cell secretory granules are densely packed with various bioactive mediators including proteases of chymase, tryptase and CPA3 type. Previous studies have indicated that mast cells can affect the outcome of melanoma but the contribution of the mast cell granule proteases to such effects has not been clear. Here we addressed this issue by assessing mice lacking either the chymase Mcpt4, the tryptase Mcpt6 or carboxypeptidase A3 (Cpa3), as well as mice simultaneously lacking all three proteases, in a model of melanoma dissemination from blood to the lung. Read More

    The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma.
    Oncotarget 2017 Feb 15. Epub 2017 Feb 15.
    Department of Biological Sciences, Kangwon National University, Chuncheon, Republic of Korea.
    Toll-like receptor (TLR) ligands are strongly considered immune-adjuvants for cancer immunotherapy and have been shown to exert direct anti-cancer effects. This study was performed to evaluate the synergistic anti-cancer and anti-metastatic effects of the TLR7 agonist imiquimod (IMQ) during radiotherapy for melanoma. The pretreatment of B16F10 or B16F1 cells with IMQ combined with γ-ionizing radiation (IR) led to enhanced cell death via autophagy, as demonstrated by increased expression levels of autophagy-related genes, and an increased number of autophagosomes in both cell lines. Read More

    Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.
    Oncotarget 2017 Feb 9. Epub 2017 Feb 9.
    Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA.
    Genome-wide association studies have identified 21 susceptibility loci associated with melanoma. These loci implicate genes affecting pigmentation, nevus count, telomere maintenance, and DNA repair in melanoma risk. Here, we report the results of a two-stage genome-wide association study of melanoma. Read More

    Analysis of variability in high throughput screening data: applications to melanoma cell lines and drug responses.
    Oncotarget 2017 Feb 15. Epub 2017 Feb 15.
    J. Craig Venter Institute, La Jolla, CA, USA.
    High-throughput screening (HTS) strategies and protocols have undergone significant development in the last decade. It is now possible to screen hundreds of thousands of compounds, each exploring multiple biological phenotypes and parameters, against various cell lines or model systems in a single setting. However, given the vast amount of data such studies generate, the fact that they use multiple reagents, and are often technician-intensive, questions have been raised about the variability, reliability and reproducibility of HTS results. Read More

    Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways.
    Oncotarget 2017 Feb 14. Epub 2017 Feb 14.
    Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
    Malignant melanoma is the deadliest form of all skin cancers. Itraconazole, a commonly used systemic antifungal drug, has been tested for its anti-tumor effects on basal cell carcinoma, prostate cancer, and non-small cell lung cancer. Whether itraconazole has any specific anti-tumor effect on melanoma remains unknown. Read More

    Ecto-5' -Nucleotidase CD73 (NT5E), vitamin D receptor and FGF23 gene polymorphisms may play a role in the development of calcific uremic arteriolopathy in dialysis patients - Data from the German Calciphylaxis Registry.
    PLoS One 2017 17;12(2):e0172407. Epub 2017 Feb 17.
    Department of Medicine, Division of Nephrology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
    Introduction: Calciphylaxis/calcific uremic arteriolopathy affects mainly end-stage kidney disease patients but is also associated with malignant disorders such as myeloma, melanoma and breast cancer. Genetic risk factors of calciphylaxis have never been studied before.

    Methods: We investigated 10 target genes using a tagging SNP approach: the genes encoding CD73/ ecto-5'-nucleotidase (purinergic pathway), Matrix Gla protein, Fetuin A, Bone Gla protein, VKORC1 (all related to intrinsic calcification inhibition), calcium-sensing receptor, FGF23, Klotho, vitamin D receptor, stanniocalcin 1 (all related to CKD-MBD). Read More

    Evaluation of choroidal tumors with optical coherence tomography: enhanced depth imaging and OCT-angiography features.
    Eye (Lond) 2017 Feb 17. Epub 2017 Feb 17.
    Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
    AimTo describe the vascular features of choroidal tumors using enhanced depth imaging (EDI), optical coherence tomography (OCT), and OCT-angiography.MethodsIn this prospective study, we evaluated 116 Caucasian patients with choroidal tumors (60 eyes with choroidal nevi, 40 with choroidal melanoma, 6 with choroidal hemangioma, 2 with optic disc melanocytoma, 6 with choroidal osteoma, and 2 with retinal metastases). Patients underwent a complete ophthalmic examination including bulbar echography, EDI-OCT, OCT-angiography, and multicolor imaging. Read More

    Fresh frozen amniotic membrane for conjunctival reconstruction after excision of neoplastic and presumed neoplastic conjunctival lesions.
    Eye (Lond) 2017 Feb 17. Epub 2017 Feb 17.
    Ocular Oncology Centre, Royal Hallamshire Hospital, Sheffield, UK.
    PurposeSuspicious neoplastic conjunctival lesions often require wide excision with tumour-free margins, leaving significant conjunctival defects requiring reconstruction. In this study we report the results of using fresh frozen amniotic membrane grafts (AMG) after wide excision of potentially malignant lesions.MethodsRetrospective review of 53 patients; between January 2011 and April 2014. Read More

    Painful nipple hyperkeratosis secondary to vemurafenib.
    Dermatol Ther 2017 Feb 17. Epub 2017 Feb 17.
    Department of Dermatology, Baylor Scott & White Health, Texas A&M Health Science Center College of Medicine, Temple, Texas, 76508.
    Vemurafenib is a selected BRAF kinase inhibitor approved for treating metastatic or unresectable melanoma, which has numerous cutaneous side effects unfortunately, including three previously reported cases of asymptomatic areola and/or nipple hyperkeratosis. We present the first case of painful bilateral nipple hyperkeratosis secondary to vemurafenib in an 84-year-old woman. She was successfully treated with tretinoin 0. Read More

    Prognostic role of Maspin expression in melanoma: probably far from clinical use.
    Histopathology 2017 Feb 17. Epub 2017 Feb 17.
    Department of Medical Sciences, Pathology Unit, University of Torino, Italy.
    Maspin, a member of the serpin superfamily, is a double-face gene enacting different activities in cancer. Several studies support that in melanoma maspin loss could contribute to disease progression and metastatic dissemination, sustaining its putative tumour-suppressor role; others did not confirm these observations[1-5]. Also, the maspin subcellular localization in immunohistochemistry (nuclear vs. Read More

    Severe bullous pemphigoid associated with pembrolizumab therapy for metastatic melanoma with complete regression.
    Clin Exp Dermatol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Dermatology, Rambam Health Care Campus, Technion, Institute of Technology, Haifa, Israel.
    Bullous pemphigoid (BP) is considered to be a humorally mediated autoimmune disease, but autoreactive T-cells and T-regulatory cells (Tregs) have also been implicated in this disease. Tregs and the programmed death-1 (PD-1) : programmed death ligand (PD-L) pathway are both critical in terminating immune response, and elimination of either can result in breakdown of tolerance and development of autoimmunity. We report a patient with metastatic malignant melanoma (MM), who underwent pembrolizumab (anti-PD-1) therapy following unsuccessful treatment with ipilimumab [anti-cytotoxic T-lymphocyte-associated protein (CTLA)-4]. Read More

    The impact of melanoma genetics on treatment response and resistance in clinical and experimental studies.
    Cancer Metastasis Rev 2017 Feb 16. Epub 2017 Feb 16.
    Unit for RNA Biology, Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 53105, Bonn, Germany.
    Recent attempts to characterize the melanoma mutational landscape using high-throughput sequencing technologies have identified new genes and pathways involved in the molecular pathogenesis of melanoma. Apart from mutated BRAF, NRAS, and KIT, a series of new recurrently mutated candidate genes with impact on signaling pathways have been identified such as NF1, PTEN, IDH1, RAC1, ARID2, and TP53. Under targeted treatment using BRAF and MEK1/2 inhibitors either alone or in combination, a majority of patients experience recurrences, which are due to different genetic mechanisms such as gene amplifications of BRAF or NRAS, MEK1/2 and PI3K mutations. Read More

    RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis.
    Biomed Res Int 2017 22;2017:8032910. Epub 2017 Jan 22.
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
    Metastasis is the main cause of treatment failure and death in cancer patients. Metastasis of tumor cells to the brain occurs frequently in individuals with breast cancer, non-small cell lung cancer, or melanoma. Despite recent advances in our understanding of the causes and in the treatment of primary tumors, the biological and molecular mechanisms underlying the metastasis of cancer cells to the brain have remained unclear. Read More

    Has Vitamin D Had Its "Time In The Sun" For Melanoma?
    J Clin Aesthet Dermatol 2016 Dec 1;9(12):11-12. Epub 2016 Dec 1.
    Division of Dermatology and Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska.
    Growing evidence suggests a pivotal role for vitamin D in cancers, particularly melanoma. The broad immunologic effects of vitamin D and its signaling axis make for a complex interplay between tumor cells and the immune system. Preclinical evidence suggests vitamin D to have protective effects in melanoma oncogenesis and progression, creating a potential role for vitamin D supplementation in cancer prevention and/or adjuvant therapy. Read More

    Melanoma in the elderly.
    G Ital Dermatol Venereol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Dermatology, University Hospital ASST Spedali Civili, Brescia, Italy.
    Background: Among older patients, melanoma in general presents biological features related to a more aggressive biology, such as more locally advanced tumor. Management of melanoma in elderly may be difficult, mainly due to comorbidities. We report the experience of the Melanoma Unit of University Hospital ASST Spedali Civili di Brescia, Italy. Read More

    Hazelnut (Corylus avellana L.) Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines.
    Int J Mol Sci 2017 Feb 13;18(2). Epub 2017 Feb 13.
    Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, I-84084 Fisciano (SA), Italy.
    Hazelnut shells, a by-product of the kernel industry processing, are reported to contain high amount of polyphenols. However, studies on the chemical composition and potential effects on human health are lacking. A methanol hazelnut shells extract was prepared and dried. Read More

    Temporal Trends in Satellite-Derived Erythemal UVB and Implications for Ambient Sun Exposure Assessment.
    Int J Environ Res Public Health 2017 Feb 10;14(2). Epub 2017 Feb 10.
    Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.
    Ultraviolet radiation (UVR) has been associated with various health outcomes, including skin cancers, vitamin D insufficiency, and multiple sclerosis. Measurement of UVR has been difficult, traditionally relying on subject recall. We investigated trends in satellite-derived UVB from 1978 to 2014 within the continental United States (US) to inform UVR exposure assessment and determine the potential magnitude of misclassification bias created by ignoring these trends. Read More

    Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: A preliminary report.
    Int J Biol Markers 2005 Jan - Mar;20(1):11-17
    Department of Biomedical Sciences and Human Oncology, Section of Dermatological Oncology, University.
    Reverse transcription polymerase chain reaction (RT-PCR) of tyrosinase mRNA has been applied for the detection of melanoma cells in the peripheral blood, lymph nodes and bone marrow of melanoma patients. We evaluated the diagnostic accuracy of RT-PCR in comparison to standard cytology and immunocytochemistry (ICC) for the identification of melanoma cells in biological fluids other than blood. Tyrosinase expression was evaluated together with standard cytology and ICC (anti-S100, HMB-45 and Melan-A antibodies) in biological fluid samples collected from 17 melanoma patients according to the site of metastatic involvement or clinical suspicion (eight cerebrospinal fluid (CSF) samples; three pleural effusions; four ascites; one bile sample, one pericardial effusion); 17 samples collected from patients with non-melanoma metastatic cancer were used as controls. Read More

    Expression and clinical significance of pepsinogen C in uveal melanomas.
    Int J Biol Markers 2004 Jul - Sep;19(3):240-244
    Department of Ophthalmology, Hospital Alvarez-Buylla, Mieres, Asturias - Spain.
    Purpose: we investigated by immunohistochemistry the pepsinogen C (pepC) expression in uveal melanomas and analyzed the possible relationship to clinicopathological parameters and prognostic significance.

    Methods: We studied 22 patients who had undergone enucleation of the eyeball or local tumor resection for uveal melanoma. The specimens were immunostained for pepC on formalin-fixed, paraffin-embedded sections. Read More

    The relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma: A meta-analysis and bioinformatics.
    PLoS One 2017 16;12(2):e0171676. Epub 2017 Feb 16.
    Laboratory of Molecular Genetics of Aging and Tumor, Medical Faculty; Kunming University of Science and Technology, Kunming, Yunnan, China.
    Background: The function of the tumor suppressor gene RASSF1A in cancer cells has been detailed in many studies. However, due to the methylation of its promoter, the expression of RASSF1A is missing in most cancers. In the literature, we found that the conclusion regarding the relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma was not unified. Read More

    Psychological characteristics of early-stage melanoma patients: a cross-sectional study on 204 patients.
    Melanoma Res 2017 Feb 15. Epub 2017 Feb 15.
    aDepartment of Psychology bDepartment of Medical Sciences, Section of Dermatology cDepartment of Neuroscience, University of Turin dClinical Psychology and Psycho-Oncology Unit eDepartment of Oncology, Section of Surgical Dermatology, AOU Città della Salute e della Scienza, Turin, Italy.
    The presence of psychological distress has a negative impact not only on cancer patients' quality of life but also on the course of the disease, with slower recovery and increased morbidity. These issues are of particular importance in melanoma patients (MP), who remain at risk of disease progression for many years after diagnosis. This study aimed to investigate psychological distress, coping strategies, and their possible relationships with demographic-clinical features in patients with early-stage melanoma in follow-up. Read More

    Small Numbers, Big Challenges: Adolescent and Young Adult Cancer Incidence and Survival in New Zealand.
    J Adolesc Young Adult Oncol 2017 Feb 16. Epub 2017 Feb 16.
    8 Children's Cancer Research Group, University of Otago, Christchurch, New Zealand .
    Purpose: This study was undertaken to determine cancer survival and describe the unique spectrum of cancers diagnosed among New Zealand's adolescents and young adult (AYA) population.

    Methods: Registrations for 1606 15-24 year olds diagnosed with a new primary malignant tumor between 2000 and 2009 were obtained from the New Zealand Cancer Registry and classified according to AYA diagnostic group and subgroup, age, sex, and prioritized ethnicity. Age-standardized incidence rates (IRs) per million person years and 5-year relative survival ratios were calculated. Read More

    Resection of Gastrointestinal Metastases in Stage IV Melanoma: Correlation with Outcomes.
    Am Surg 2016 Nov;82(11):1109-1116
    Department of Cutaneous Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
    The prognosis of patients with gastrointestinal (GI) melanoma metastases is poor. Surgery renders select patients disease free and/or palliates symptoms. We reviewed our single-institution experience of resection with GI melanoma metastases. Read More

    Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition.
    Sci Rep 2017 Feb 16;7:42604. Epub 2017 Feb 16.
    Department of Cancer Biology, Vanderbilt University School of Medicine, 2220 Pierce Avenue, Nashville, TN 37232, USA.
    Dysregulated metabolism can broadly affect therapy resistance by influencing compensatory signaling and expanding proliferation. Given many BRAF-mutated melanoma patients experience disease progression with targeted BRAF inhibitors, we hypothesized therapeutic response is related to tumor metabolic phenotype, and that altering tumor metabolism could change therapeutic outcome. We demonstrated the proliferative kinetics of BRAF-mutated melanoma cells treated with the BRAF inhibitor PLX4720 fall along a spectrum of sensitivity, providing a model system to study the interplay of metabolism and drug sensitivity. Read More

    Extracellular protonation modulates cell-cell interaction mechanics and tissue invasion in human melanoma cells.
    Sci Rep 2017 Feb 13;7:42369. Epub 2017 Feb 13.
    Institute of Physiology II, University of Münster, Münster, Germany.
    Detachment of cells from the primary tumour precedes metastatic progression by facilitating cell release into the tissue. Solid tumours exhibit altered pH homeostasis with extracellular acidification. In human melanoma, the Na(+)/H(+) exchanger NHE1 is an important modifier of the tumour nanoenvironment. Read More

    Vedolizumab treatment for immune checkpoint inhibitor-induced enterocolitis.
    Cancer Immunol Immunother 2017 Feb 15. Epub 2017 Feb 15.
    Department of Gastroenterology, Skane University Hospital, 22185, Lund, Sweden.
    Immune checkpoint inhibitors (ICPI), such as ipilimumab [anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) antibody] and nivolumab or pembrolizumab [anti-programmed cell death protein-1 (PD-1) antibodies], improve survival in several cancer types. Since inhibition of CTLA-4 or PD-1 leads to non-selective activation of the immune system, immune-related adverse events (irAEs) are frequent. Enterocolitis is a common irAE, currently managed with corticosteroids and, if necessary, anti-tumor necrosis factor-α therapy. Read More

    Inhibition of the Innate Immune Receptors for Foreign DNA Sensing Improves Transfection Efficiency of Gene Electrotransfer in Melanoma B16F10 Cells.
    J Membr Biol 2017 Feb 15. Epub 2017 Feb 15.
    Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, 1000, Ljubljana, Slovenia.
    Gene electrotransfer upregulate DNA pattern recognition receptors or DNA sensors, which are part of the innate immune system. In this study, we tested if addition of the cocktail of innate immune system inhibitors to the cells during gene electrotransfer (GET) can increase transfection efficiency and cell survival. The results indicate that this cocktail can decrease cytosolic DNA sensors expression after GET, and consequently increase cell survival and transfection efficiency in B16 cells, but only in highly metastatic B16F10 subtype. Read More

    The lactoferricin B-derived peptide, LfB17-34, induces melanogenesis in B16F10 cells.
    Int J Mol Med 2017 Feb 9. Epub 2017 Feb 9.
    Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei 100, Taiwan, R.O.C.
    Lactoferricin B (LfcinB), a peptide of bovine lactoferrin (LfB), exhibits multiple biological functions, including antimicrobial, antiviral, antioxidant and immunomodulatory activities. However, the role of LfcinB-related peptides in melanogenesis remains unclear. In this study, a set of five LfcinB-related peptides was examined. Read More

    Heat shock antagonizes UVA-induced responses in murine melanocytes and melanoma cells: an unexpected interaction.
    Photochem Photobiol Sci 2017 Feb 16. Epub 2017 Feb 16.
    Laboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.
    The skin is under the influence of oscillatory factors such as light and temperature. This organ possesses a local system that controls several aspects in a time-dependent manner; moreover, the skin has a well-known set of opsins whose function is still unknown. We demonstrate that heat shock reduces Opn2 expression in normal Melan-a melanocytes, while the opposite effect is found in malignant B16-F10 cells. Read More

    Therapeutic approach to treating patients with BRAF-mutant lung cancer: latest evidence and clinical implications.
    Ther Adv Med Oncol 2017 Jan 3;9(1):46-58. Epub 2016 Oct 3.
    Department of Pulmonary Diseases, VU University Medical Center, and Department of Thoracic Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
    Lung adenocarcinoma is known for its high rate of somatic mutations and genomic rearrangements. The identification of epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements that sensitize tumors to specific drugs has changed the therapeutic approach and prognosis in these molecularly-defined subgroups. Several other key genetic alterations have been identified, of which BRAF mutations are found in 4% of non-small cell lung cancer (NSCLC) cases. Read More

    Recurrent Malignant Melanoma Presenting as Isolated Pleural Metastases in a Patient with Chronic Lymphocytic Leukemia.
    Case Rep Oncol 2017 Jan-Apr;10(1):86-90. Epub 2017 Jan 19.
    Department of Hematology/Oncology, Feist Weiller Cancer Center/LSU Health Sciences Center, Shreveport, LA, USA.
    Isolated pleural metastasis with pleural effusion is a rare occurrence in malignant melanoma. We report an unusual case of a patient with chronic lymphocytic leukemia (CLL) and recurrent pleural effusions. The pleural fluid cytology and immunohistochemistry profile were consistent with the diagnosis of CLL. Read More

    Uveal melanoma: epidemiology, etiology, and treatment of primary disease.
    Clin Ophthalmol 2017 31;11:279-289. Epub 2017 Jan 31.
    Division of Hematology/Oncology, Columbia University Medical Center, New York, NY, USA.
    Uveal melanoma (UM) is the most common intraocular malignancy and arises from melanocytes in the iris, ciliary body, or choroid. Early diagnosis and local treatment is crucial, as survival correlates with primary tumor size. However, approximately 50% of patients will develop metastatic disease with 6-12 months' survival from metastatic diagnosis. Read More

    Early experiences of planning stereotactic radiosurgery using 3D printed models of eyes with uveal melanomas.
    Clin Ophthalmol 2017 31;11:267-271. Epub 2017 Jan 31.
    Department of Simulation and Virtual Medical Education, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
    Objective: The objective of this study was to determine the use of 3D printed model of an eye with intraocular tumor for linear accelerator-based stereotactic radiosurgery.

    Methods: The software for segmentation (3D Slicer) created virtual 3D model of eye globe with tumorous mass based on tissue density from computed tomography and magnetic resonance imaging data. A virtual model was then processed in the slicing software (Simplify3D(®)) and printed on 3D printer using fused deposition modeling technology. Read More

    Virus-Specific CD8(+) T Cells Infiltrate Melanoma Lesions and Retain Function Independently of PD-1 Expression.
    J Immunol 2017 Feb 15. Epub 2017 Feb 15.
    Department of Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107;
    It is well known that CD8(+) tumor-infiltrating lymphocytes (TILs) are correlated with positive prognoses in cancer patients and are used to determine the efficacy of immune therapies. Although it is generally assumed that CD8(+) TILs will be tumor-associated Ag (TAA) specific, it is unknown whether CD8(+) T cells with specificity for common pathogens also infiltrate tumors. If so, the presence of these T cells could alter the interpretation of prognostic and diagnostic TIL assays. Read More

    1 OF 2231