150,035 results match your criteria Malignant Melanoma


Clinical outcomes of high-risk cutaneous squamous cell carcinomas treated with Mohs micrographic surgery alone: an analysis of local recurrence, regional nodal metastases, progression-free survival, and disease-specific death.

J Am Acad Dermatol 2022 Jun 24. Epub 2022 Jun 24.

Zitelli and Brodland Skin Cancer Center, Pittsburgh, PA 15232; University of Pittsburgh Medical Center, Pittsburgh, PA 15232.

Importance: The incidence of cutaneous squamous cell carcinomas (cSCC) continues to increase, and is now predicted that deaths from cSCC will surpass that of melanoma within the next 5 years. Although most cSCCs are successfully treated, there exists an important subset of high-risk tumors that have the highest propensity for local recurrence (LR), nodal metastasis (NM), and disease-specific death (DSD).

Objective: We investigated the clinical outcomes of high-risk cSCCs treated with MMS alone, analyzing LR, NM, DM, and DSD. Read More

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The combinational application of photodynamic therapy and nanotechnology in skin cancer treatment: A review.

Tissue Cell 2022 Jun 15;77:101856. Epub 2022 Jun 15.

Biophysics Department, Faculty of Science, Cairo University, Egypt.

Skin cancer is considered a risky worldwide disease. Traditional treatments have several weaknesses, necessitating the creation of more effective treatments. In this case, photodynamic therapy and nanotechnology were used to demonstrate their therapeutic efficacy as combinational approaches in treating different types of skin cancer. Read More

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Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy.

J Am Chem Soc 2022 Jun 27. Epub 2022 Jun 27.

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

The blood-brain barrier (BBB) presents a major hurdle in the development of central nervous system (CNS) active therapeutics, and expression of the P-glycoprotein (P-gp) efflux transporter at the blood-brain interface further impedes BBB penetrance of most small molecules. Designing efflux liabilities out of compounds can be laborious, and there is currently no generalizable approach to directly transform periphery-limited agents to ones active in the CNS. Here, we describe a target-agnostic, prospective assessment of P-gp efflux using diverse compounds. Read More

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Scrambling for BRAF Mutation Status in Patients With Melanoma: Is It Really Necessary to Initiate Treatment?

JCO Oncol Pract 2022 Jun 27:OP2200267. Epub 2022 Jun 27.

Muhammad Zain Farooq, MD, Department of Hematology and Oncology, Moffitt Cancer Center, University of South Florida, Tampa, FL; and Ankit Mangla, MD, Seidman Cancer Center, University Hospitals, Cleveland, OH, Division of Hematology and Oncology, Case Western Reserve University School of Medicine, Cleveland, OH.

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Research Trends in Immune Checkpoint Blockade for Melanoma: Visualization and Bibliometric Analysis.

J Med Internet Res 2022 Jun 27;24(6):e32728. Epub 2022 Jun 27.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Background: Melanoma is one of the most life-threatening skin cancers; immune checkpoint blockade is widely used in the treatment of melanoma because of its remarkable efficacy.

Objective: This study aimed to conduct a comprehensive bibliometric analysis of research conducted in recent decades on immune checkpoint blockade for melanoma, while exploring research trends and public interest in this topic.

Methods: We summarized the articles in the Web of Science Core Collection on immune checkpoint blockade for melanoma in each year from 1999 to 2020. Read More

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Skin cancer risk factors among Black South Africans-The Johannesburg Cancer Study, 1995-2016.

Immun Inflamm Dis 2022 Jul;10(7):e623

National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa.

Background: The Black population has lower skin cancer incidence compared to White, Indian/Asian, and Mixed-race populations in South Africa; however, skin cancer still exists in the Black population. The aim of this study is to identify risk factors associated with skin cancer among Black South Africans.

Materials And Methods: A case-control study was conducted. Read More

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Investigation of the Distribution of Magnetic Nanoparticles in Tumor Tissues by the Method of Scanning Magnetic Force Nanotomography.

Dokl Biochem Biophys 2022 Jun 27;504(1):115-117. Epub 2022 Jun 27.

Shumakov National Medical Research Center of Transplantology and Artificial Organs, Moscow, Russia.

The development of effective biomedical technologies using magnetic nanoparticles (MNPs) for the tasks of oncotherapy and nanodiagnostics requires the development and implementation of new methods for the analysis of micro- and nanoscale distributions of MNPs in the volume of cells and tissues. The paper presents a new approach to three-dimensional analysis of MNP distributions - scanning magnetic force nanotomography as applied to the study of tumor tissues. Correlative reconstruction of MNP distributions and nanostructure features of the studied tissues made it possible to quantitatively estimate the parameters of three-dimensional distributions of composite nanoparticles based on silicon and iron oxide obtained by femtosecond laser ablation and injected intravenously and intratumorally into tumor tissue samples of B16/F1 mouse melanoma. Read More

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18F-FDG PET/CT and HRCT: a combined tool for risk stratification in idiopathic inflammatory myopathy-associated interstitial lung disease.

Clin Rheumatol 2022 Jun 27. Epub 2022 Jun 27.

Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhongshan Er Road, 510080, Guangzhou, China.

Objectives: Rapidly progressive interstitial lung disease (RP-ILD) is a life-threatening form of idiopathic inflammatory myopathy (IIM)-associated interstitial lung disease (ILD). We aimed to assess the combination of F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) and high-resolution computed tomography (HRCT) for the quantification of IIM-ILD activity and risk stratification for RP-ILD.

Method: Patients with IIM and undergoing F-FDG PET/CT were included in this retrospective study. Read More

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Potential IL2 Substitute Shrinks Solid Tumors.

Authors:

Cancer Discov 2022 Jun 27:OF1. Epub 2022 Jun 27.

Nemvaleukin alfa, an engineered cytokine that may induce the tumor-fighting benefits of IL2 without the side effects, has demonstrated effectiveness against solid tumors. As a monotherapy, the drug produced overall response rates of 13% in patients with advanced melanoma and 18.2% in advanced renal cell carcinoma. Read More

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Ability to Predict Melanoma Within 5 Years Using Registry Data and a Convolutional Neural Network: A Proof of Concept Study.

Acta Derm Venereol 2022 Jun 27. Epub 2022 Jun 27.

Research relating to machine learning algorithms, including convolutional neural networks, has increased during the past 5 years. The aim of this pilot study was to investigate how accurately a convolutional neural network, trained on Swedish registry data, could perform in predicting cutaneous invasive and in situ melanoma (CMM) within 5 years. A cohort of 1,208,393 individuals was used. Read More

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Multimodal Applications of Zinc Gallate-Based Persistent Luminescent Nanoparticles in Cancer Treatment: Tumor Margining, Diagnosis, and Boron Neutron Capture Therapy.

ACS Appl Bio Mater 2022 Jun 27. Epub 2022 Jun 27.

Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.

On the basis of the boron neutron capture therapy (BNCT) modality, we have designed and synthesized a zinc gallate (ZnGaO)-based nanoformulation for developing an innovative theranostic approach for cancer treatment. Initially, the (ZnGaCrO or ZnGaO:(0.5%)Cr persistent luminescence nanoparticles (PLNPs) embedded on silica matrix were synthesized. Read More

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Retrospective analysis of hepatic perivascular epithelioid cell tumour (PEComa) in a single centre for clinical diagnosis and treatment clinical diagnosis and treatment of hepatic PEComa.

Medicine (Baltimore) 2022 Jun 24;101(25):e29506. Epub 2022 Jun 24.

Department of Hepatobiliary Centre, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Abstract: Our primary objective was to investigate the clinical features, diagnosis, treatment and prognosis of hepatic perivascular epithelioid cell tumour (PEComa).Thirty-five cases of pathologically proven hepatic PEComa that were treated in the Department of Hepatobiliary Centre of the First Affiliated Hospital of Nanjing Medical University from January 2008 to February 2019 were retrospectively analysed, and the literature was also reviewed.Twenty-nine females and 6 males were included in this study. Read More

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[Efficacy of the encorafenib + binimetinib combination in a BRAF mutated metastatic melanoma case report].

Recenti Prog Med 2022 Jun;113(6):28e-30e

Malignant melanoma is a malignant tumor with a poor prognosis. From 2010 the discovery of mutation of BRAF and the development of drugs against this target significantly improved the survival of these patients. The best results were achieved with the double inhibition of the MAPK pathway. Read More

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SIIV position paper: clinical approach to vulval diseases: need for quality standards.

Minerva Obstet Gynecol 2022 Jun 22. Epub 2022 Jun 22.

Section of Dermatology and Infectious Diseases, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

This paper summarizes the position of the Italian Society of Vulvology (SIIV) on the clinical approach to vulval disease. A thorough history (general medical, gynaecological, and vulval history) is essential for a successful and fruitful vulvological examination. Characteristics of pruritus (itch) and pain, that are the two main vulval symptoms, should be collected and reported with precision, according to duration, temporal course, location, provocation, and intensity. Read More

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NSUN2-mediated RNA mC modification modulates uveal melanoma cell proliferation and migration.

Epigenetics 2022 Jun 26:1-12. Epub 2022 Jun 26.

School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

RNA 5-methylcytosine (mC) is a widespread post-transcriptional modification involved in diverse biological processes through controlling RNA metabolism. However, its roles in uveal melanoma (UM) remain unknown. Here, we describe the biological roles and regulatory mechanisms of RNA mC in UM. Read More

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Adoptive cell therapy with tumour-infiltrating lymphocytes: the emerging importance of clonal neoantigen targets for next-generation products in non-small cell lung cancer.

Immunooncol Technol 2019 Oct 9;3:1-7. Epub 2019 Oct 9.

Achilles Therapeutics Ltd, Stevenage Bioscience Catalyst, Stevenage, UK.

Immune checkpoint blockade has significantly improved clinical outcomes for patients with non-small cell lung cancer (NSCLC) and other solid tumours, but many patients do not respond and acquired resistance is common. Aspects of the tumour microenvironment linked to clinical outcomes include the proportion of tumour-infiltrating lymphocytes (TIL), tumour programmed death ligand 1 ( PD-L1) score and tumour mutation burden. Adoptive cell therapy (ACT), a technique that works by infusing expanded T lymphocytes to increase the effector cell pool in tumours, is anticipated to become a viable therapeutic option for patients with solid tumours, akin to chimeric antigen receptor T cell (CAR-T) therapy in haematological malignancies. Read More

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October 2019

mutations predict survival benefit in advanced cancer patients treated with immune checkpoint inhibitors.

Immunooncol Technol 2021 Jun 9;10:100035. Epub 2021 Aug 9.

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, USA.

Background: Numerous biomarkers are being tested to enhance the ability of clinicians to predict responses and prognosis after treatment with immune checkpoint inhibitors (ICIs). Polycomb repressive complex 2 (PRC2) is a histone methyltransferase family that plays a major role in chromatin silencing. Preclinical evidence implicates PRC2 components such as enhancer of zeste homolog 2 (EZH2) in immune resistance. Read More

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Treatment of uncontrolled intraocular pressure secondary to uveal melanoma status post plaque radiotherapy with ab interno XEN gel stent implantation.

Am J Ophthalmol Case Rep 2022 Sep 16;27:101610. Epub 2022 Jun 16.

Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, 608 Stanton L Young Blvd, Oklahoma City, OK, 73104, Oklahoma, USA.

Purpose: To report treatment of uncontrolled intraocular pressure in a patient with uveal melanoma status post plaque radiotherapy with ab interno XEN gel stent implantation.

Observations: A 21-year-old female with a history of iris and ciliary body melanoma underwent treatment with plaque radiotherapy with subsequent elevation of intraocular pressure refractory to maximum medical therapy. In order to control the pressure, ab interno XEN gel stent implantation with mitomycin C was recommended. Read More

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September 2022

A New Methodology to Estimate Drug Cost Avoidance in Clinical Trials: Development and Application.

Front Oncol 2022 8;12:889575. Epub 2022 Jun 8.

Pharmacy Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.

Background: Oncology clinical trials can lead to relevant financial savings in drug acquisition for healthcare providers. Considerable methodological heterogeneity is observed among previous studies estimating these savings.

Methods: We developed a methodology to estimate the economic benefit obtained from the enrollment of patients into clinical trials through the analysis of drug cost avoidance. Read More

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Circulating Tumor DNA Testing Supports Rapid Therapeutic Decision-Making in Metastatic Melanoma: A Case Report.

Front Oncol 2022 10;12:846187. Epub 2022 Jun 10.

Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, United States.

Treatment of metastatic melanoma includes the option of targeted therapy in patients with driver mutations. BRAF-MEK inhibitor drugs improve survival in the approximately 50% of patients with melanoma that harbor mutations. As mutation detection in tissue often takes days to weeks, it is not always possible or timely to obtain status in tissue using immunohistochemistry or next generation sequencing. Read More

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Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review.

Front Oncol 2022 10;12:913217. Epub 2022 Jun 10.

Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, China.

Immune checkpoint inhibitors (ICIs) have opened up a new way for tumor therapy but simultaneously led to the occurrence of immune-related adverse events. We report a case of successful treatment of PD-1 inhibitor-associated colitis with fecal microbiota transplantation (FMT). The patient was a palatal malignant melanoma who developed diarrhea and hematochezia accompanied by fever, gastrointestinal bleeding, and infection after the third treatment with PD-1 (Toripalimab). Read More

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Cucurbitacin B, Purified and Characterized From the Rhizome of Exhibits Anti-Melanoma Potential.

Front Oncol 2022 8;12:903832. Epub 2022 Jun 8.

Department of Biotechnology, University of Calicut, Malappuram, India.

The ethnomedicinal plant from the Cucurbitaceae family, , or its bioactive derivatives have been widely utilized in traditional medicine owing to their distinct applications against various human ailments and have lured the interest of ethnobotanists and biochemists. Here, we report for the first time, the anti-cancer potential of a bio-active fraction isolated from the dried rhizome of , and the bioactive principle identified as cucurbitacin B (Cu-B). The purification processes involving the utilization of multiple organic extracts of rhizome powder, yielded Cu-B from the Ethyl acetate Cytotoxic Fraction (ECF), obtained by the chromatographic separation of the ethyl acetate extract. Read More

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Pneumocystis Infection in Two Patients Treated with Both Immune Checkpoint Inhibitor and Corticoids.

J Immunother Precis Oncol 2020 Feb 10;3(1):27-30. Epub 2020 Feb 10.

Department of Dermatology, Erasme Hospital, ULB, Brussels, Belgium.

The introduction of immune checkpoint inhibitor (ICI) targeting cytotoxic T-lymphocyte-associated antigen-4 and programmed cell death receptor 1 has dramatically improved clinical outcome for cancer patients. Nevertheless, this treatment can be associated with immune-related adverse events (irAEs) which sometimes need management with prolonged immune suppression. In order to analyze the risk of pneumonia (PJP) in this population, all PJP cases at our oncological hospital between 2004 and 2019 were searched. Read More

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February 2020

miR-204-5p in vivo inhibition cause diminished CD45RO cells rate in lungs of melanoma B16-bearing mice.

Noncoding RNA Res 2022 Sep 3;7(3):133-141. Epub 2022 Jun 3.

Department of Pathophysiology, Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.

The treatment of melanoma remains a challenge, despite novel approaches recently becoming available for disseminated tumors. RNA targeting is being intensively studied in various types of disease. The aim of the present study was to explore whether the in vivo use of a microRNA (miR)-204-5p inhibitor affected melanoma progression, and whether its metastasis affects target organ remodeling. Read More

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September 2022

Encorafenib and Binimetinib Combination Therapy in Metastatic Melanoma.

J Adv Pract Oncol 2022 May 21;13(4):450-455. Epub 2022 Jun 21.

Carolinas Medical Center, Charlotte, North Carolina.

The treatment landscape for metastatic melanoma has changed dramatically over the past few years as new medications have been developed. Encorafenib, a B-Raf protein kinase inhibitor, and binimetinib, a MEK inhibitor, were approved by the U.S. Read More

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Gene editing: Towards the third generation of adoptive T-cell transfer therapies.

Immunooncol Technol 2019 Jul 14;1:19-26. Epub 2019 Jun 14.

Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, USA.

First-generation adoptive T-cell transfer (ACT) administering tumor-infiltrating lymphocytes (TILs), and second-generation ACT using autologous T cells genetically modified to express tumor-specific T-cell receptors (TCRs) or chimeric antigen receptors (CARs) have both shown promise for the treatment of several cancers, including melanoma, leukemia and lymphoma. However, these treatments require labor-intensive manufacturing of the cell product for each patient, frequently utilize lentiviral or retroviral vectors to genetically modify the T cells, and have limited antitumor efficacy in solid tumors. Gene editing is revolutionizing the field of gene therapy, and ACT is at the forefront of this revolution. Read More

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Nanoparticles with rough surface improve the therapeutic effect of photothermal immunotherapy against melanoma.

Acta Pharm Sin B 2022 Jun 1;12(6):2934-2949. Epub 2021 Dec 1.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

Photothermal therapy has been intensively investigated for treating cancer in recent years. However, the long-term therapeutic outcome remains unsatisfying due to the frequently occurred metastasis and recurrence. To address this challenge, immunotherapy has been combined with photothermal therapy to activate anti-tumor immunity and relieve the immunosuppressive microenvironment within tumor sites. Read More

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Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells.

Acta Pharm Sin B 2022 Jun 4;12(6):2905-2922. Epub 2022 Mar 4.

Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallography and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1-indole derivatives that display high potential and specificity towards group II PAKs. Among these inhibitors, compound exhibited excellent inhibitory activity and kinase selectivity, displayed superior anti-migratory and anti-invasive properties against the lung cancer cell line A549 and the melanoma cell line B16. Read More

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Rational Design of Polyglutamic Acid Delivering an Optimized Combination of Drugs Targeting Mutated BRAF and MEK in Melanoma.

Adv Ther (Weinh) 2020 Aug 12;3(8). Epub 2020 May 12.

Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

Targeted therapies against cancer can relieve symptoms and induce remission, however, they often present limited duration of disease control, cause side effects and often induce acquired resistance. Therefore, there is a great motivation to develop a unique delivery system, targeted to the tumor, in which we can combine several active entities, increase the therapeutic index by reducing systemic exposure, and enhance their synergistic activity. To meet these goals, we chose the biocompatible and biodegradable poly(α,L-glutamic acid) (PGA) as a nanocarrier that facilitates extravasation-dependent tumor targeting delivery. Read More

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Using a Participatory Approach to Develop Research Priorities for Future Leaders in Cancer-Related Precision Public Health.

Front Genet 2022 9;13:881527. Epub 2022 Jun 9.

Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, United States.

Precision public health is an emerging discipline combining principles and frameworks of precision health with the goal of improving population health. The development of research priorities drawing on the strengths of precision and public health is critical to facilitate the growth of the discipline to improve health outcomes. We held an interactive workshop during a virtual conference bringing together early-career researchers across public health disciplines to identify research priorities in precision public health. Read More

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