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Neuropathology 2022 Jun 22. Epub 2022 Jun 22.

Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Angiomatoid fibrous histiocytomas (AFH) is a rare soft tissue tumor of intermediate malignant potential, and its histology is diverse. It can occur in several organs including intracranial and soft tissues. Here, we report two cases of brain parenchymal classic AFH and spinal extramedullary myxoid mesenchymal tumor with clinicopathological and molecular investigations by next-generation sequencing and a comprehensive review. Read More

Surg Oncol Clin N Am 2022 Jul;31(3):419-430

Maria Sklodowska-Curie National Research Institute of Oncology, Sarcoma and Melanoma, Roentgena 5, 02-781 Warszawa, Poland. Electronic address:

Undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS) are genomically complex tumors commonly diagnosed in the extremities or trunk of elderly patients. They likely represent a spectrum of disease differentiated by myxoid stroma and curvilinear vessels observed in MFS but not in UPS. Limb-sparing surgery is the standard of care although the infiltrative nature of MFS mandates wider resection margins than are necessary for UPS. Read More

J Maxillofac Oral Surg 2022 Jun 25;21(2):701-704. Epub 2020 Jul 25.

Sinhgad Dental College and Hospital, Pune, India.

Sarcomas are malignancies arising from mesenchymal (nonepithelial) tissue and are broadly classified into sarcomas of soft tissue and bone. Soft tissue sarcomas of the head and neck are rare; they comprise < 1% of head and neck cancers and < 10% of all soft tissue sarcomas (Chang et al. in Otolaryngol Head Neck Surg 151:976-983, 2014). Read More

World J Surg Oncol 2022 Jun 13;20(1):199. Epub 2022 Jun 13.

Department of Gastrointestinal Surgery, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo, 105-8461, Japan.

Background: Undifferentiated pleomorphic sarcoma (UPS) is a malignant soft tissue tumor that has been reclassified from malignant fibrous histiocytoma with the development of the pathological diagnosis. It principally occurs in the extremities but rarely occurs in the rectum. We herein report a rare case of UPS arising in the rectum. Read More

Dermatol Online J 2022 Jan 15;28(1). Epub 2022 Jan 15.

Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA Dermatology Service, VA New York Harbor Healthcare System, Brooklyn, New York, USA.

Pleomorphic dermal sarcoma (PDS) was recognized in the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone as a clinical entity with adverse histopathologic features compared to the more superficial and less aggressive atypical fibroxanthoma (AFX). Although the gold standard treatment of AFX is Mohs micrographic surgery (MMS), the optimal treatment for PDS has yet to be determined. We report the case of a 71-year-old man with a PDS with perineural invasion on the scalp, with no recurrence one-year post-treatment with MMS and adjuvant radiation therapy. Read More

J Clin Pathol 2022 Mar 22. Epub 2022 Mar 22.

Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan

Aims: Dermatofibroma/fibrous histiocytoma (DF/FH) is a common cutaneous mesenchymal neoplasm exhibiting benign biological behaviour. However, the immunohistochemical utility of erythroblast transformation-specific-related gene (ERG) for diagnosing DF remains unknown. The authors reviewed the immunohistochemical status of ERG in different subtypes of DF and in its differential diagnoses. Read More

Arch Bone Jt Surg 2022 Jan;10(1):67-77

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Soft-Tissue Sarcoma (STS) is a heterogeneous group of neoplasms of mesenchymal origin, occurring in connective tissues. According to previously conducted studies, STS accounts for approximately 1% and 7-%15% of adult and pediatric malignancies, respectively. Almost 50%-60% of sarcomas arise from extremities and usually present as a large painless or rarely painful soft-tissue mass. Read More

Ann Diagn Pathol 2022 Jun 10;58:151914. Epub 2022 Feb 10.

SA Pathology at Flinders Medical Centre, Bedford Park, South Australia 5024, Australia. Electronic address:

By a set of curious chances, Dr. F.M. Read More

J Int Med Res 2022 Mar;50(3):3000605221082852

Department of Internal Medicine, Division of Hematology and Oncology, Naef K. Basile Cancer Institute, 66984American University of Beirut Medical Center, American University of Beirut Medical Center, Beirut, Lebanon.

Objectives: Most epidemiologic studies on soft tissue sarcomas (STS) and bone sarcomas (BS) are performed in western countries, with few in the Middle East and North Africa region. We describe the epidemiology of sarcomas in Lebanon using the medical records database at the American University of Beirut Medical Center (AUBMC).

Methods: This single-center retrospective cohort study included patients with sarcomas registered in the database between 2015 and 2019. Read More

JNMA J Nepal Med Assoc 2022 Feb 15;60(246):200-203. Epub 2022 Feb 15.

Department of Radiology, B&B Hospital Pvt. Ltd., Gwarko, Lalitpur, Nepal.

Angiomatoid fibrous histiocytoma is an uncommon soft tissue neoplasm with potential for recurrence and rare metastasis. The majority of cases are painless, slow growing and occur in superficial extremities of young adults. Here we report a case of Angiomatoid fibrous histiocytoma in a 28-year-old male patient presenting as a slowly growing painful mass in the groin region. Read More

Hum Pathol 2022 05 15;123:113-122. Epub 2022 Feb 15.

Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing, 100005, China. Electronic address:

Cardiac undifferentiated pleomorphic sarcoma (UPS) is a rare malignancy. Several studies have revealed frequent MDM2, CDK4, PDFGRA, and KIT amplifications and CDKN2A and CDKN2B deletions. Cases lacking the above copy number alterations may harbor alternative driver mutations; however, little is known about such occurrences. Read More

Indian J Nucl Med 2021 Oct-Dec;36(4):462-464. Epub 2021 Dec 15.

Department of Nuclear Medicine, Medanta, Lucknow, Uttar Pradesh, India.

Malignant fibrous histiocytoma (MFH)/undifferentiated pleomorphic sarcoma (UPS) is an uncommon malignancy in the head-and-neck region. UPS is a malignant neoplasm of uncertain origin that arises both in soft tissue and bone. We bring forth a 65-year-old female who presented with an ulceroproliferative growth in the right upper neck. Read More

Turk Gogus Kalp Damar Cerrahisi Derg 2021 Oct 20;29(4):552-555. Epub 2021 Oct 20.

Department of Thoracic Surgery, Ankara University School of Medicine, Ankara, Turkey.

Undifferentiated pleomorphic sarcoma or, as formerly called, malignant fibrous histiocytoma is a type of sarcoma which originates from fibroblast and histiocytic cells. It is the most common type of sarcoma among all soft tissue sarcomas in adults. Its most common site is the lower limb, followed by the upper limb and the retroperitoneum. Read More

Front Cell Dev Biol 2021 25;9:751833. Epub 2021 Nov 25.

Department of Orthopedic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Malignant fibrous histiocytoma (MFH) is a common type of soft tissue sarcoma and a serious threat to human health. MFH often relapses locally after the curettage is related to the residual cancer stem cells (CSCs). Currently, the dysregulation of microRNA (miRNA) has been found to be closely related to the recurrence of CSCs. Read More

Int J Surg Case Rep 2021 Dec 2;89:106555. Epub 2021 Nov 2.

King Abdullah Medical City, 21955, Muzdalifah Rd, Makkah, Saudi Arabia. Electronic address:

Introduction And Importance: Undifferentiated pleomorphic sarcoma (UPS) is one of the most common sarcomas affecting elderly patients, majority of UPS usually in the extremities, trunk, and retroperitoneum. However, its rarely observed in the digestive system. There are minimal data published regarding this topic. Read More

Int J Low Extrem Wounds 2021 Nov 18:15347346211060125. Epub 2021 Nov 18.

37128College of Medicine, 26713The Catholic University of Korea, Seoul, Korea.

Malignant transformation of chronic burn scars are usually toward cutaneous lineages, including squamous cell carcinoma, basal cell carcinoma, and malignant melanoma. Sarcomas are less common. Undifferentiated pleomorphic sarcoma(UPS) is a subtype of soft tissue sarcoma with storiform-pleomorphic cells of uncertain origin, and has sparingly been reported to arise from burn scars. Read More

J Surg Res 2022 02 29;270:313-320. Epub 2021 Oct 29.

Department of Orthopedic Surgery, Section of Orthopedic Oncology, Rush University Medical Center, Chicago, Illinois.

Background: This investigation compared outcomes of patients with undifferentiated pleomorphic sarcoma of soft tissue (UPS-S) to UPS of bone (UPS-B).

Methods: The Surveillance, Epidemiology, and End Results database was reviewed from 1975-2016. Disease-specific survival (DSS) was estimated using Kaplan-Meier, and a multivariable Cox regression model identified factors prognostic of DSS. Read More

Hum Cell 2022 Jan 19;35(1):384-391. Epub 2021 Oct 19.

Division of Rare Cancer Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Undifferentiated pleomorphic sarcoma (UPS), previously termed malignant fibrous histiocytoma, is one of the most aggressive sarcomas with no identifiable line of differentiation. Although the molecular mechanism of oncogenesis in UPS has not been clarified, radiation exposure is considered to be a risk factor in the development of UPS. In the treatment of UPS, surgical treatment remains the most important modality. Read More

Clin Nucl Med 2022 Feb;47(2):e208-e209

Nuclear Medicine, Changhai Hospital, Navy Medical University, Shanghai, China.

Abstract: Dendritic fibromyxolipoma is a rare recently described benign soft tissue tumor, which may be misinterpreted histologically as myxoid liposarcoma or myxoid malignant fibrous histiocytoma. We describe FDG PET/CT and MRI findings of a dendritic fibromyxolipoma incidentally detected in a case with rectal adenocarcinoma. The dendritic fibromyxolipoma showed inhomogeneous FDG uptake with SUVmax of 4. Read More

Case Rep Orthop 2021 30;2021:9434222. Epub 2021 Sep 30.

Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Angiomatoid fibrous histiocytoma (AFH) is a rare intermediate malignant tumor that arises mainly in soft tissues, especially in the superficial extremities of patients younger than 30 years. There have been a few reports of AFH arising from sites other than soft tissue, including bone, and unusual site and age make it difficult to diagnose this rare tumor. . Read More

World J Clin Cases 2021 Sep;9(26):7930-7936

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

Background: Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas among adults. It is characterized by large size, high grade, and biological aggressiveness. There are many reports of MFH after local stimulation, such as bone fracture, implants, and chronic osteomyelitis. Read More

Arkh Patol 2021 ;83(5):31-38

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Health of Russia, Moscow, Russia.

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of intermediate malignancy potential, which predominantly affects children and young adults. This paper describes two cases of AFH, as well as a review of literature during 1979 to 2021. It gives data on the epidemiology, clinical features, diagnosis, and genetic characteristics of AFH. Read More

Cureus 2021 Aug 6;13(8):e16958. Epub 2021 Aug 6.

Radiodiagnosis, St. John's Hospital, Bengaluru, IND.

Malignant fibrous histiocytoma currently known as undifferentiated pleomorphic sarcoma is the commonest soft tissue sarcoma of mesenchymal origin. Undifferentiated pleomorphic sarcoma is commonly located in the extremities, trunk, head and neck in decreasing order of frequency. We report a case of primary undifferentiated pleomorphic sarcoma of the biceps femoris muscle in a 50-year-old male complicated by hemorrhage. Read More

Brain Pathol 2022 01 27;32(1):e13010. Epub 2021 Jul 27.

Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, Paris, France.

FET:CREB fusions have been described in a variety of tumors from various phenotypes. Recently, these fusion transcripts were reported in intracranial tumors, variably named intracranial mesenchymal myxoid tumors or angiomatoid fibrous histiocytomas. Controversy remains concerning the terminology for these tumors. Read More

Neuropathology 2021 Aug 12;41(4):306-314. Epub 2021 Jul 12.

Department of Pathology, National University Health System, Singapore, Singapore.

Angiomatoid fibrous histiocytoma (AFH) is an uncommon soft tissue neoplasm that can exhibit diverse morphological features, including myxoid change. Rarely, the tumor occurs intracranially and poses considerable diagnostic challenges to neuropathologists. This is compounded by a recently coined entity, referred to as intracranial myxoid mesenchymal tumor (IMMT). Read More

J Stomatol Oral Maxillofac Surg 2022 06 2;123(3):e106-e111. Epub 2021 Jul 2.

Department of Oral and Maxillofacial Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma in late adulthood and usually occurs in the limbs, trunk, and peritoneum. Less than 10% of MFH cases occur in the head and neck region. The clinical manifestations and pathological features of MFH are atypical, and it is difficult to make a clinical diagnosis. Read More

J Thorac Dis 2021 Apr;13(4):2649-2660

Mainz University Thoracic Center, Thoracic Surgery and Pulmonary Medicine, Mainz, Germany.

Background: Soft tissue sarcoma (STS) tend to metastasis to the lungs. Pulmonary metastasectomy seems to be a common practice always when plausible. The objective of this article was to review systematically the results of a literature search on pulmonary metastasectomy for STSs published in the last ten years and to offer a brief overview about the current practice as well. Read More

Clin Orthop Relat Res 2021 05;479(5):1134-1143

K. Jamshidi, A. Bagherifard, A. Mirzaei, Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.

Background: Heterotopic ossification (HO) is common after total joint arthroplasty and usually does not cause diagnostic problems. However, the occurrence of HO after oncologic prostheses implantation can be troublesome as it may mimic a locally recurrent tumor. Because this distinction could have a profound impact on the surgeon and patient, it is important to distinguish the two entities; to our knowledge, no study has evaluated this after oncologic endoprosthetic reconstruction around the knee after tumor resection. Read More