1,649 results match your criteria Malignant Fibrous Histiocytoma Soft Tissue


Malignant Fibrous Histiocytoma of the Scalp with Skull Invasion: A Rare and Aggressive Presentation.

Cureus 2020 Apr 23;12(4):e7801. Epub 2020 Apr 23.

Plastic, Reconstructive and Hand Surgery, Northwell Health/Donald and Barbara Zucker School of Medicine, Staten Island University Hospital, Staten Island, USA.

Malignant fibrous histiocytoma (MFH) is an undifferentiated high-grade pleomorphic sarcoma and is considered the most common primary soft tissue sarcoma in adults. MFH is known to arise in the trunk, extremities and retroperitoneum although it can arise anywhere in the body.MFH of the skin is uncommon and even less frequent is the involvement of the scalp, especially with skull invasion. Read More

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http://dx.doi.org/10.7759/cureus.7801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243839PMC

Giant Cell Sarcomas in Domestic Rabbits ().

Vet Pathol 2020 Jul 29;57(4):490-496. Epub 2020 Apr 29.

Michigan State University, Lansing, MI, USA.

Multinucleated giant cells (MGCs) are a prominent histological feature of various mesenchymal neoplasms and are often considered a criterion of malignancy. Mesenchymal neoplasms with MGCs for which the cell lineage is unclear generally are referred to as giant cell sarcomas. Here we characterize the gross, histologic, and immunohistochemical features of 90 giant cell sarcomas in domestic pet rabbits. Read More

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http://dx.doi.org/10.1177/0300985820921814DOI Listing

Angiomatoid Fibrous Histiocytoma With ALK Expression in an Unusual Location and Age Group.

Am J Dermatopathol 2020 Apr 17. Epub 2020 Apr 17.

Cellular Pathology, St George's University Hospital, London, United Kingdom.

Angiomatoid fibrous histiocytoma (AFH) is a relatively rare soft tissue tumor of intermediate malignant potential, occurring most commonly in young adults, with a recognized propensity for local recurrence and occasional metastasis. A case of AFH occurring on the finger of a 60-year-old man is described in which the unusual location and age group for this entity raised the original wrong diagnosis of an aneurysmal and cellular fibrous histiocytoma. Further workup demonstrated an EWSR1-CREB1 translocation, confirming the correct diagnosis of AFH. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001649DOI Listing

A splenic 'cyst': histology confirmed splenic sarcoma.

Ann R Coll Surg Engl 2020 May 1;102(5):e105-e106. Epub 2020 Apr 1.

Hull Royal Infirmary, Hull and East Yorkshire Hospitals NHS Trust, Hull, UK.

Primary malignant fibrous histiocytoma, now classified as pleomorphic undifferentiated sarcoma, is the most common soft-tissue sarcoma in adult life. Primary splenic pleomorphic undifferentiated sarcoma is extremely rare and aggressive, and is associated with a poor prognosis; only 14 cases of splenic pleomorphic undifferentiated sarcoma have been documented in the English literature. We discuss a case of a 56-year-old woman with iron-deficiency anaemia, early satiety and left upper-quadrant pain, who was preoperatively diagnosed with a large splenic cyst following thorough investigation. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0035DOI Listing

Efficacy and safety of anlotinib, a multikinase angiogenesis inhibitor, in combination with epirubicin in preclinical models of soft tissue sarcoma.

Cancer Med 2020 May 17;9(10):3344-3352. Epub 2020 Mar 17.

Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Anlotinib is a novel, orally administered, multitarget receptor tyrosine kinase inhibitor. It functions by inhibiting tumor angiogenesis and proliferative signaling pathways. In this study, we aimed to investigate the efficacy and safety of anlotinib plus epirubicin in a sarcoma patient-derived xenografts (PDX) model. Read More

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http://dx.doi.org/10.1002/cam4.2941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221313PMC

[Spontaneous Disappearance of Undifferentiated Pleomorphic Primary Mesenteric Sarcoma-A Case Report].

Gan To Kagaku Ryoho 2019 Dec;46(13):2568-2570

Dept. of Surgery, Kohsei Chuo General Hospital.

The patient was a 49-year-old man with persistent fever since the introduction of hemodialysis(HD). Vomiting and abdominal swelling appeared 4 months after initiating hemodialysis. Computed tomography(CT)scan revealed a tumor measuring 9 cm, and disorders of passage from the jejunum. Read More

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December 2019

Rare pancreatic metastasis of undifferentiated pleomorphic sarcoma originating from the pelvis: A case report.

Int J Surg Case Rep 2020 21;68:140-144. Epub 2020 Feb 21.

Department of Orthopedic Surgery, National Hospital Organization Shikoku Cancer Center, 160 Minamiumemotomachikou, Matsuyama-shi, Ehime, Japan.

Introduction: Undifferentiated pleomorphic sarcoma (UPS) is a reclassification of malignant fibrous histiocytoma by the World Health Organization in 2002. UPS, the most common soft tissue sarcoma reported in adults, mostly recurs as lung disease. Pancreatic metastasis of UPS is extremely rare. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.02.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063109PMC
February 2020

Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature.

Int J Environ Res Public Health 2020 02 23;17(4). Epub 2020 Feb 23.

Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, 80100 Naples, Italy.

Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in adults. It occurs only occasionally in oral soft tissues, and knowledge about its characteristics is based on a limited number of cases reported in the literature. Malignant fibrous histiocytoma belongs to the group of soft tissue sarcomas and makes up less than 10% of soft tissue sarcomas. Read More

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http://dx.doi.org/10.3390/ijerph17041426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068479PMC
February 2020

Local recurrences after the treatment of soft tissue malignant fibrous histiocytoma (unclassified pleomorphic sarcoma) of the limbs

Wiad Lek 2019 Aug;72(8):1523-1526

Introduction: The treatment of patients with malignant fibrous histiocytoma as well as other soft tissue sarcomas is not sufficiently effective up to date, and has largely changed and reflects the alterations, occurred in oncology as a whole. The number of amputation decreased over the last 10-15 years. Some researchers associate the improvement of treatment outcomes with the development of combined and complex methods. Read More

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The Management of Head and Neck Sarcoma.

J Craniofac Surg 2020 Mar/Apr;31(2):e189-e192

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, No. 30 Zhongyang Road, Nanjing, China.

Objective: To describe the incidence, types, features, treatment and outcomes of head and neck sarcoma managed at a treatment center in eastern China.

Methods: Cases of head and neck soft tissue sarcoma and osteogenic sarcoma treated at the Stomatology Hospital of Nanjing University between 2008 and 2018 were retrospectively analyzed. Patient characteristics, site of lesion, main presenting symptoms, treatment, histology, local recurrence, development of metastatic disease, duration of follow-up and survival rates are described and compared. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006162DOI Listing
January 2020

Efficacy and Safety of Nanosomal Docetaxel Lipid Suspension-Based Chemotherapy in Sarcoma: A Multicenter, Retrospective Study.

Sarcoma 2019 15;2019:3158590. Epub 2019 Nov 15.

Jina Pharmaceuticals Inc., Libertyville, Green Oaks, Illinois 60048, USA.

Objective: To evaluate the efficacy and safety of nanosomal docetaxel lipid suspension (NDLS, DoceAqualip) based chemotherapy in patients with sarcoma.

Methods: In this retrospective, multicenter (6 centers), observational study, we analyzed the medical charts of adult patients of either sex, who were treated with NDLS (75 mg/m in 3-weekly cycles) based chemotherapy for the treatment of sarcoma. The efficacy outcomes were overall response rate (ORR: complete response (CR) + partial response (PR)) and disease control rate (DCR: CR + PR + stable disease (SD)) in patients who received NDLS-based chemotherapy in neoadjuvant and metastatic settings. Read More

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http://dx.doi.org/10.1155/2019/3158590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881752PMC
November 2019

Large Malignant Fibrous Histiocytoma Treated with Hypofractionated Proton Beam Therapy and Local Hyperthermia.

Int J Part Ther 2019 15;6(1):35-41. Epub 2019 May 15.

Department of Radiation Oncology and Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Purpose: Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas. The standard treatment is adequate surgical resection; in addition, radiation therapy plays a major role in perioperative treatment in most cases. Herein, we report the case of a patient with a large MFH who was successfully treated with combined proton beam therapy (PBT) and local hyperthermia (LH). Read More

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http://dx.doi.org/10.14338/IJPT-18-00046.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871629PMC

Atypical fibroxanthoma, rare and often unrecognized cutaneous soft tissue tumor - a case report and review of the literature.

Cesk Patol 2019 ;55(3):182-186

Atypical fibroxanthoma (AFX) is a rare cutaneous soft tissue tumor typically occurring in the elderly on sun exposed skin. Histologically, it is composed of pleomorphic, atypical cells with multiple mitoses including atypical mitotic figures resembling undifferentiated malignant tumor. AFX is considered to be a benign tumor with almost uniformly excellent prognosis following conservative therapy if strict diagnostic criteria are applied. Read More

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December 2019

Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report.

Urol Case Rep 2019 Nov 5;27:101004. Epub 2019 Sep 5.

Department of Pathology, Tama-Hokubu Medical Center, 1-7-1 Aobacho, Higashimurayama, Tokyo, 189-8511, Japan.

Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma. Renal MFH is rare and information about its molecular characterization is limited. We present here the case of a 77-year-old man who was incidentally found to have a huge right renal mass on computed tomography. Read More

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http://dx.doi.org/10.1016/j.eucr.2019.101004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798660PMC
November 2019
1 Read

Surgical Treatment of Oral Cavity Nodular Fasciitis.

J Craniofac Surg 2020 Mar/Apr;31(2):e108-e110

Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples.

Background: Nodular fascitiis is a myofibroblastic neoplasm of the soft tissue that rarely affects oral cavity. With a broad pattern of presentation, sometimes Nodular Fascitiis can have a rapid growth and appear highly cellular with local aggressiveness on biopsies, thus simulating a sarcoma. The aim of this paper is to present a case of troublesome diagnosis of nodular fascitiis mimicking a Malignant Fibrous Histiocytoma, with the purpose of alert clinicians and pathologists on the difficulties that can be met in the differential diagnosis between these 2 lesions. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005877DOI Listing

SOX9 Immunohistochemistry in the Distinction of Angiomatoid Fibrous Histiocytoma From Histologic Mimics: Diagnostic Utility and Pitfalls.

Appl Immunohistochem Mol Morphol 2019 Sep 18. Epub 2019 Sep 18.

Department of Pathology, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh.

Angiomatoid fibrous histiocytoma (AFH) can be diagnostically difficult because of its varied histologic appearance and potential to occur at unusual sites. The identification of recurrent rearrangements (EWSR1-CREB1, EWSR1-ATF1, and FUS-ATF1) is a helpful diagnostic tool. Additional immunohistochemical markers in AFH could aid in restricting the differential diagnosis and selecting appropriate cases for targeted molecular studies. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000809DOI Listing
September 2019
20 Reads

Difficult diagnosis of Angiomatoid Fibrous Histiocytoma of the leg mimicking a benign condition.

J Radiol Case Rep 2019 Apr 30;13(4):38-45. Epub 2019 Apr 30.

Musculoskeletal Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Angiomatoid fibrous histiocytoma is a rarely metastasizing soft-tissue tumor of low-grade malignancy. Here we report a case of angiomatoid fibrous histiocytoma located in the leg of a 15-year-old female. This case is of particular interest due to its radiological features that led to raise two questions concerning the nature of the disease (is it reactive or tumoral?) and its site of origin (within soft tissues or the tibial periosteum?). Read More

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http://dx.doi.org/10.3941/jrcr.v13i4.3414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743639PMC
April 2019
2 Reads

[Ultrasound and MRI features of malignant fibrous histiocytoma of soft tissue].

Zhongguo Gu Shang 2019 Aug;32(8):736-741

Department of Ultrasound, Huzhou Central Hospital, Huzhou 313000, Zhejiang, China;

Objective: To investigate ultrasound and MRI features of malignant fibrous histiocytoma (MFH) of soft tissue.

Methods: Ultrasound, MRI images and pathological data of 12 patients with malignant fibrous histiocytoma in soft tissue confirmed by operation and pathology were analyzed from January 2012 to August 2018, inlcuding 7 males and 5 females, aged from 36 to 69 years old with an average age of 53 years old; the courses of disease ranged from 4 to 49 months with an average of 28 months. Clinical manifestations were soft tissue masses and pain in the affected limbs. Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2019.08.012DOI Listing
August 2019
2 Reads

Primary pulmonary undifferentiated pleomorphic sarcoma (PPUPS).

Autops Case Rep 2019 Jul-Sep;9(3):e2019110. Epub 2019 Aug 22.

University of California, Los Angeles (UCLA), UCLA Santa Monica Medical Center. Santa Monica, CA, United States of America.

Undifferentiated pleomorphic sarcoma (UPS) is a high-grade pleomorphic neoplasm with no identifiable line(s) of differentiation using currently available diagnostic techniques. Therefore, it is essentially a diagnosis of exclusion, which requires generous tissue sampling, adequate contextually interpreted immunohistochemistry, and relevant molecular studies. UPS is a common soft tissue sarcoma (historically one of the entities referred to as malignant fibrous histiocytoma (MFH)), which can develop in various organs, but lung involvement is usually due to metastasis. Read More

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http://dx.doi.org/10.4322/acr.2019.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709651PMC
August 2019
2 Reads

A population-based study of soft tissue sarcoma incidence and survival in Australia: An analysis of 26,970 cases.

Cancer Epidemiol 2019 12 11;63:101590. Epub 2019 Sep 11.

Department of Surgery, The University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia.

Background: Soft tissue sarcomas (STS) are rare, often fatal tumors, but little is known of the epidemiology and survival in the Australian population. This study aims to provide the first epidemiological analysis of incidence and survival rates of STS in the Australian population.

Methods: A retrospective population-based observational study was conducted between 1982 and 2009 of all patients with a diagnosis of STS using the Australian Institute of Health and Welfare (AIHW) Australian Cancer Database. Read More

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http://dx.doi.org/10.1016/j.canep.2019.101590DOI Listing
December 2019
7 Reads

Endoscopic submucosal dissection of tracheal deep benign fibrous histiocytoma using hybrid knife.

Onco Targets Ther 2019 11;12:5609-5613. Epub 2019 Jul 11.

Department of Pulmonary and Critical Care Medicine, First Hospital of China Medical University, Shenyang, People's Republic of China.

Deep benign fibrous histiocytoma (FH) is an uncommon and poorly recognized tumor that arises in subcutaneous or deep soft tissue. Deep benign FH of the trachea is even more rare. Deep benign FH recurs in approximately 20% of cases, so surgical resection is the recommended treatment for FH. Read More

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http://dx.doi.org/10.2147/OTT.S213747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628974PMC
July 2019
5 Reads
1.342 Impact Factor

Predicting the prognosis of undifferentiated pleomorphic soft tissue sarcoma: a 20-year experience of 266 cases.

ANZ J Surg 2019 09 30;89(9):1045-1050. Epub 2019 Jul 30.

Department of Orthopaedics, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

Background: Undifferentiated pleomorphic sarcoma (UPS) is a rare malignant tumour of mesenchymal origin, which was conceived following re-classification of malignant fibrous histiocytoma (MFH). The objective of this study is to determine prognostic factors for the outcome of UPS, following multi-modal treatment.

Methods: Data of UPS tumours from 1996 to 2016 were collected, totalling 266 unique UPS patients. Read More

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http://dx.doi.org/10.1111/ans.15348DOI Listing
September 2019
6 Reads

Differing characteristics of cartilaginous lesions of the larynx.

Eur Arch Otorhinolaryngol 2019 Oct 23;276(10):2635-2647. Epub 2019 Jul 23.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029 HUS,, Helsinki, Finland.

Introduction: The tissues of the laryngeal region only rarely harbor primary cartilaginous lesions, and squamous cell carcinoma remains the most frequently encountered malignant tumor in this area.

Materials And Methods: We reviewed the salient histological features of cartilaginous laryngeal lesions to provide differential diagnostics and guidelines for distinguishing the benign from the malignant ones.

Results: Cartilaginous neoplasms of the larynx include chondroma and chondrosarcoma. Read More

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http://dx.doi.org/10.1007/s00405-019-05563-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757023PMC
October 2019
5 Reads

Soft-tissue sarcoma in adolescents and young adults compared with older adults: A report among 5000 patients from the Scandinavian Sarcoma Group Central Register.

Cancer 2019 10 9;125(20):3595-3602. Epub 2019 Jul 9.

Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Background: In recent years, there has been growing awareness of the distinct characteristics of adolescents and young adults (AYA) diagnosed with cancer. Soft-tissue sarcoma (STS) accounts for approximately 1% of all cancers diagnosed in adults and 8% of cancers diagnosed in AYA. To the best of our knowledge, only a few sarcoma registers include data regarding histological subtype, age at diagnosis, and detailed clinical information. Read More

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http://dx.doi.org/10.1002/cncr.32367DOI Listing
October 2019
1 Read

Intracranial angiomatoid fibrous histiocytoma with Hodgkin lymphoma.

Med J Malaysia 2019 06;74(3):234-236

St. Michael's Hospital, Neurosurgery Department, Toronto, Ontario, Canada.

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumour of uncertain differentiation and low metastatic potential, which occurs predominantly in children and young adults. It occurs mostly within the extremities, trunk, head and neck. We report the case of a 32-year-old female that was operated in our hospital in 2016 and twice in 2017. Read More

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June 2019
3 Reads

Clinical Outcomes of Surgical Treatment for Primary Chest Wall Soft Tissue Sarcoma.

Korean J Thorac Cardiovasc Surg 2019 Jun 5;52(3):148-154. Epub 2019 Jun 5.

Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Background: This study investigated the clinical outcomes of surgical treatment of primary chest wall soft tissue sarcoma (CW-STS).

Methods: Thirty-one patients who underwent surgery for CW-STS between 2000 and 2015 were retrospectively reviewed. The disease-free and overall survival rates were estimated using the Kaplan-Meier method, and prognostic factors were analyzed using a Cox proportional hazards model. Read More

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http://dx.doi.org/10.5090/kjtcs.2019.52.3.148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559192PMC
June 2019
5 Reads

Angiomatoid Fibrous Histiocytoma Mimicking Eosinophilic Granuloma in a Pediatric Patient.

World Neurosurg 2019 Sep 21;129:345-348. Epub 2019 Jun 21.

Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Background: Angiomatoid fibrous histiocytoma (AFH) is a rare low-grade malignant tumor mainly occurring in soft tissues, and its incidence in the bones is extremely rare. Although most of the existing reports focus on the pathological features of AFH, only a few describe its imaging features. To our knowledge, this is the first case of AFH in the skull, and it is distinguished from eosinophilic granuloma based on imaging results. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193165
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http://dx.doi.org/10.1016/j.wneu.2019.06.102DOI Listing
September 2019
3 Reads

Primary Undifferentiated Pleomorphic Sarcoma of the Colon Mesentery.

Ann Coloproctol 2019 May 31:152-154. Epub 2019 May 31.

Department of Surgery, Wonkwang University Hospital, Wonkwang University School of Medicine, Iksan, Korea.

An undifferentiated pleomorphic sarcoma (UPS), also known as a malignant fibrous histiocytoma in the past, commonly involves the soft tissue of the extremities and the retroperitoneum. However, a primary UPS of the colon mesentery is very rare. A 69-year-old male patient visited our outpatient department for treatment of an enlarged, palpable mass in the right lower quadrant (RLQ). Read More

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http://dx.doi.org/10.3393/ac.2018.03.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625777PMC
May 2019
5 Reads

MAGE-A3 is a Clinically Relevant Target in Undifferentiated Pleomorphic Sarcoma/Myxofibrosarcoma.

Cancers (Basel) 2019 May 15;11(5). Epub 2019 May 15.

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

Melanoma-associated antigen 3 (MAGE-A3) expression is generally restricted to the placenta and germline cells of the testis, but it may also be expressed in sarcoma and other cancers and is associated with poor prognosis. Immunotherapy approaches targeting MAGE-A3 in other cancers have shown mixed results in the clinic, however, use of cancer testis antigens such as MAGE-A3 may have therapeutic value in the treatment of soft tissue sarcomas. Based on the recent success of anti-programmed death-1 (PD-1) therapy in undifferentiated pleomorphic sarcoma, we hypothesize that MAGE-A3-based immunotherapies may also provide benefits in this sarcoma type. Read More

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https://www.mdpi.com/2072-6694/11/5/677
Publisher Site
http://dx.doi.org/10.3390/cancers11050677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562561PMC
May 2019
25 Reads

Small soft tissue masses indeterminate at imaging: histological diagnoses at a tertiary orthopedic oncology clinic.

Skeletal Radiol 2019 Oct 22;48(10):1555-1563. Epub 2019 Mar 22.

Department of Radiology, University of Miami Miller School of Medicine/Jackson Memorial Hospital, 1611 NW 12th Ave, JMH WW 279, Miami, FL, 33136, USA.

Objective: To review histologic diagnoses of soft-tissue masses (STMs) ≤ 2 cm with indeterminate imaging features encountered in musculoskeletal oncology clinic at a tertiary referral center.

Materials And Methods: This was an IRB-approved retrospective review of patients with STMs ≤ 2 cm, referred to our tertiary care orthopedic oncology clinic over 4.75 consecutive years. Read More

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http://link.springer.com/10.1007/s00256-019-03205-0
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http://dx.doi.org/10.1007/s00256-019-03205-0DOI Listing
October 2019
38 Reads

[Bilateral back elastofibroma after resection of malignant fibrous histiocytoma of the right upper arm: a case report].

Zhongguo Gu Shang 2019 Feb;32(2):170-172

Department of Orthopaedics, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China;

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http://dx.doi.org/10.3969/j.issn.1003-0034.2019.02.015DOI Listing
February 2019
7 Reads

Large Undifferentiated Pleomorphic Sarcoma of the Posterior Thigh.

Authors:
Austin H Allen

Am J Case Rep 2019 Mar 11;20:318-322. Epub 2019 Mar 11.

Osteopathic Medical Student, University of Pikeville-Kentucky College of Osteopathic Medicine, Pikeville, KY, USA.

BACKGROUND Sarcomas account for less than 1% of all cancers. Undifferentiated Pleomorphic Sarcoma, formerly called Malignant Fibrous Histiocytoma, is a rare subtype identified by a lack specific immunohistochemical markers for a specific lineage of differentiation. These soft tissue tumors are aggressive and rapidly enlarge. Read More

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http://dx.doi.org/10.12659/AJCR.914079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421979PMC
March 2019
8 Reads

Hybrid bronchoscopic and surgical resection of endotracheal angiomatoid fibrous histiocytoma.

J Cardiothorac Surg 2019 Feb 28;14(1):48. Epub 2019 Feb 28.

Department of Cardiothoracic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Angiomatoid fibrous histiocytoma (AFH) is a soft-tissue tumor that generally affects the extremities of children and young adults. AFH overlaps with primary pulmonary myxoid sarcoma (PPMS) and can occur in unusual locations.

Case Presentation: We present a case of a 22-year-old female with AFH in the distal trachea. Read More

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http://dx.doi.org/10.1186/s13019-019-0861-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393981PMC
February 2019
5 Reads

Metachronous Malignant Fibrous HistiocytomaA Rare Case Report.

Iran J Pathol 2018 25;13(4):474-478. Epub 2018 Sep 25.

Dept. of Pathology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.

Malignant fibrous histiocytoma (MFH) is one of the most common types of soft tissue sarcomas in adults. Distant metastases are developed in 30-40% of patients with MFH, with the most common site being the lung. However, metachronous MFH has not been reported previously in literature. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358554PMC
September 2018
7 Reads

Detection of Metastasis in a Patient-derived Orthotopic Xenograft (PDOX) Model of Undifferentiated Pleomorphic Sarcoma with Red Fluorescent Protein.

Anticancer Res 2019 Jan;39(1):81-85

AntiCancer Inc., San Diego, CA, U.S.A.

Background/aim: Undifferentiated pleomorphic sarcoma (UPS) is a common soft tissue sarcoma and highly recalcitrant. We have previously developed patient-derived orthotopic xenograft (PDOX) mouse models of UPS and other major sarcoma types. Unlike PDOX models of other cancer types, it has been difficult to demonstrate metastasis in the sarcoma PDOX models. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13082DOI Listing
January 2019
9 Reads

[Application of deep circumflex iliac artery based iliac-internal oblique musculofascial chimeric flaps in reconstruction of complex oromandibular defects].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 12;32(12):1567-1571

Department of Head and Neck Surgery, Cancer Hospital of Shantou University Medical College, Shantou Guangdong, 515031, P.R.China.

Objective: To evaluate the reliability and effectiveness of a deep circumflex iliac artery based iliac-internal oblique musculofascial chimeric flap (DCIA-IIOF) in reconstruction of complex oromandibular defect.

Methods: Between January 2010 and December 2015, DCIA-IIOFs were used to repair complex oromandibular defects in 11 patients. There were 8 males and 3 females, with an age of 27-75 years (median, 56 years). Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201806023
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http://dx.doi.org/10.7507/1002-1892.201806023DOI Listing
December 2018
33 Reads

Differences in the Efficacies of Pazopanib and Gemcitabine/Docetaxel as Second-Line Treatments for Metastatic Soft Tissue Sarcoma.

Oncology 2019 18;96(2):59-69. Epub 2018 Oct 18.

Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of

Background: We retrospectively investigated the treatment outcomes of second-line treatment with pazopanib or gemcitabine/docetaxel in patients with advanced soft tissue sarcoma (STS).

Methods: Ninety-one patients who were treated with pazopanib or gemcitabine/docetaxel for advanced STS between 1995 and 2015 were analyzed.

Results: Forty-six and 45 patients received pazopanib and gemcitabine/docetaxel, respectively. Read More

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http://dx.doi.org/10.1159/000492597DOI Listing
February 2019
36 Reads
2.422 Impact Factor

Post-radiation sarcoma: A study by the Eastern Asian Musculoskeletal Oncology Group.

PLoS One 2018 17;13(10):e0204927. Epub 2018 Oct 17.

Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, Republic of Korea.

The oncologic risk of ionizing radiation is widely known. Sarcomas developing after radiotherapy have been reported, and they are a growing problem because rapid advancements in cancer management and screening have increased the number of long-term survivors. Although many patients have undergone radiation treatment in Asian countries, scarce reports on post-radiation sarcomas (PRSs) have been published. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204927PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192585PMC
March 2019
44 Reads

[Angiomatoid fibrous histiocytoma of the radial pulse groove].

Ann Dermatol Venereol 2018 Dec 4;145(12):756-760. Epub 2018 Oct 4.

Laboratoire d'anatomie et de cytologie pathologiques, CHU de Rouen, 1, rue de Germont, 76000 Rouen, France.

Background: Angiomatoid fibrous histiocytoma (AFH) is a slowly progressing rare soft-tissue tumour of moderate malignant potential. It is most commonly seen in children and young adults. Clinically, the lesion is easily confused with a haematoma or soft-tissue haemangioma, and the radiological aspects are not specific. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638183052
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http://dx.doi.org/10.1016/j.annder.2018.07.024DOI Listing
December 2018
5 Reads

Undifferentiated Pleomorphic Sarcoma Metastatic to the Orbit.

Ophthalmic Plast Reconstr Surg 2018 Nov/Dec;34(6):e193-e195

Department of Ophthalmology and Visual Science.

Undifferentiated pleomorphic sarcoma is a malignancy of mesenchymal origin, which was previously known as malignant fibrous histiocytoma. It is known to occur on rare occasion as a primary orbital tumor, but no known cases of metastatic orbital involvement have been reported since 2002, when the reclassification of these tumors took place. The authors report a patient who presented with a metastasis to the left orbit 2 years after undergoing treatment of a high-grade undifferentiated pleomorphic sarcoma of the right thigh. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001240DOI Listing
May 2019
8 Reads
0.914 Impact Factor

Acute Trauma Precipitating the Onset of Chest Wall Myxofibrosarcoma.

Indian J Surg Oncol 2018 Sep 20;9(3):411-413. Epub 2018 Jun 20.

1Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136 USA.

A previously healthy, 47-year-old male presented to his primary care physician with the complaint of a nontender, palpable breast mass discovered coincidentally 1 month after being scratched in the same location by his pet cat. Family history revealed his father was diagnosed with a soft tissue sarcoma of the thigh, 6 months following a traumatic injury in the same location. Cat scratch disease was considered; however, antibody testing was negative. Read More

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http://link.springer.com/10.1007/s13193-018-0768-0
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http://dx.doi.org/10.1007/s13193-018-0768-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154359PMC
September 2018
18 Reads

Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma.

Int J Cancer 2019 02 4;144(4):859-867. Epub 2018 Dec 4.

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.

Soft-tissue sarcomas are rare, heterogeneous, and often aggressive mesenchymal cancers. Many of them are associated with poor outcome, partially because biomarkers that can identify high-risk patients are lacking. Studies on sarcomas are often limited by small sample-sizes rendering the identification of biomarkers difficult when focusing on individual cohorts. Read More

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http://dx.doi.org/10.1002/ijc.31903DOI Listing
February 2019
35 Reads

[Myxoid variant of angiomatoid fibrous histiocytoma: a clinicopathologic analysis of 3 cases].

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):700-705

Department of Pathology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To study clinicopathologic features, diagnosis and differential diagnosis of myxoid variant of angiomatoid fibrous histiocytoma (AFH). Three cases of myxoid variant of AFHs were collected from First Affiliated Hospital of Nanjing Medical University during 2008 and 2017. EnVision method and fluorescence in situ hybridization(FISH) were used to detect immunophenotype and EWSR1 gene rearrangement, respectively. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.09.010DOI Listing
September 2018
13 Reads

PET in the Diagnostic Management of Soft Tissue Sarcomas of Musculoskeletal Origin.

PET Clin 2018 Oct;13(4):609-621

Keck School of Medicine, University of Southern California (USC), 1520 San Pablo Street, Suite L1600, Los Angeles, CA 90033.

Soft tissue sarcomas (STSs) account for less than 1% of adult solid tumors and about 7% of pediatric malignancies, causing 2% of cancer-related deaths. With the advent of PET-computed tomography (CT), the value of (18) fluorine-2-fluoro-2-deoxy-d-glucose (FDG) PET imaging to improve the management of STSs has been explored. FDG PET imaging has been found useful in restaging and treatment response assessment. Read More

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http://dx.doi.org/10.1016/j.cpet.2018.05.011DOI Listing
October 2018
11 Reads

Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6 cases of clear cell sarcoma-like gastrointestinal tumor.

Diagn Pathol 2018 Sep 15;13(1):73. Epub 2018 Sep 15.

Department of Surgical Pathology, Sapporo Medical University, School of Medicine, Sapporo, Hokkaido, 060-8543, Japan.

Background: Clear cell sarcoma of soft tissue (CCSST) and clear cell sarcoma-like gastrointestinal tumor (CCSLGT) are malignant mesenchymal tumors that share some pathological features, but they also have several different characteristics. They are well known to express chimeric fusions of Ewing sarcoma breakpoint region 1 (EWSR1) and cAMP response element-binding protein (CREB) family members; namely, EWSR1-activating transcription factor 1 (ATF1) and EWSR1-CREB1. In addition, recent studies have suggested the presence of other fusions. Read More

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http://dx.doi.org/10.1186/s13000-018-0752-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138919PMC
September 2018
25 Reads

Ulcerated congenital plexiform fibrohistiocytic tumor: Case report and literature review.

Pediatr Dermatol 2018 Nov 31;35(6):e360-e362. Epub 2018 Aug 31.

Department of Dermatology, La Paz Hospital, Madrid, Spain.

A newborn boy presented with a progressively infiltrating and painful congenital ulcerated plaque on the back of his left foot. A partial excision was performed and histopathologic examination confirmed a diagnosis of a plexiform fibrohistiocytic tumor. This rare tumor usually appears in children and adolescents, with congenital presentations even more uncommon. Read More

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http://dx.doi.org/10.1111/pde.13652DOI Listing
November 2018
21 Reads

Prognostic significance of microscopic tumor extension in local recurrence of myxofibrosarcoma and undifferentiated pleomorphic sarcoma.

Pathol Int 2018 Sep 9;68(9):509-516. Epub 2018 Aug 9.

Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.

Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) frequently display infiltrative growth into the adjacent normal soft tissue. In this study, we aimed to determine whether the microscopic extension into surrounding normal tissue can influence the local recurrence of MFS and UPS. A total of 42 cases (22 MFS and 20 UPS) were examined. Read More

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http://dx.doi.org/10.1111/pin.12709DOI Listing
September 2018
2 Reads

Evaluation of incidence and histolopathological findings of soft tissue sarcomas in genitourinary tract: Uludag university experience.

Int Braz J Urol 2019 Jan-Feb;45(1):68-73

Department of Surgical Pathology, Uludag University, Faculty of Medicine, Bursa, Turkey.

Purpose: In this study we aimed to review urological soft tissue sarcomas of genitourinary tract that were diagnosed in our institution and their prognostic factors for survival.

Materials And Methods: The clinical and pathological records of 31 patients who had diagnosis of soft tissue sarcomas primarily originating from the genitourinary tract between 2005-2011 were reviewed.

Results: The most common site was kidney (17 cases, 54. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442136PMC
June 2019
32 Reads

Undifferentiated Pleomorphic Sarcoma of Pancreas: A Case Report and Review of the Literature for the Last Updates.

Case Rep Med 2018 31;2018:1510759. Epub 2018 May 31.

Department of Radiation Oncology, Isfahan Milad Hospital, Isfahan, Iran.

The most prevalent type of soft tissue sarcoma is undifferentiated pleomorphic sarcoma (UPS) or previously known as malignant fibrous histiocytoma. It accounts over 20% of all soft tissue sarcomas and occurs most frequently in the extremities, trunk, and retroperitoneum. However, it has been rarely observed in the digestive system. Read More

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http://dx.doi.org/10.1155/2018/1510759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000869PMC
May 2018
13 Reads

Therapeutic response of metastatic angiomatoid fibrous histiocytoma carrying EWSR1-CREB1 fusion to the interleukin-6 receptor antibody tocilizumab.

Pediatr Blood Cancer 2018 10 22;65(10):e27291. Epub 2018 Jun 22.

Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas.

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that has been associated with EWSR1-CREB1 gene fusion. Outcome in patients with unresectable distant metastases is generally fatal. Interleukin-6 (IL-6) secretion has been described in tumors with EWSR1-CREB1 fusion, and may promote tumor growth due to autocrine stimulation. Read More

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http://dx.doi.org/10.1002/pbc.27291DOI Listing
October 2018
13 Reads