Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.
San Diego Family Dermatology, National City, CA Touro University California College of Osteopathic Medicine, Vallejo, CA Scripps Family Medicine Residency, Scripps Mercy Hospital Chula Vista, Chula Vista, CA Family Medicine Residency, Family Health Centers of San Diego, San Diego, CA.
Pleomorphic dermal sarcoma is a cutaneous soft tissue sarcoma that presents as a rapidly enlarging tumor, typically on a sun-exposed location of elderly individuals. The neoplasm shares many similar features - clinical, pathologic, immunohistochemical and genomic - with atypical fibroxanthoma. However, adverse histologic characteristics (deep subcutaneous invasion, tumor necrosis, lymphovascular invasion, and/or perineural invasion) differentiate pleomorphic dermal sarcoma from atypical fibroxanthoma and may account for the more aggressive biologic behavior of pleomorphic dermal sarcoma: local recurrence and metastases. Read More