J Pharmacol Exp Ther 2020 04 26;373(1):122-134. Epub 2020 Feb 26.
Neuropharmacology Research Group, Institute of Clinical Sciences (A.R., G.G., A.J.C., C.A.B., O.Q., N.M.B.) and Institute of Immunology and Immunotherapy (Z.S.), College of Medical and Dental Sciences and DB - Diagnostics, Drugs, Devices and Biomarkers, Cancer Research UK Clinical Trials Unit (K.B.), University of Birmingham, Edgbaston, Birmingham, United Kingdom; Department of Life Science, School of Health Sciences, Birmingham City University, Birmingham, United Kingdom (A.D.P.); Shanghai Medicilon Inc., Shanghai, China (C.C.); Chengdu SciMount Pharmatech Co. Ltd., Chengdu, China (D.X., J.H.); ConSynance Therapeutics, Inc., Rensselaer, New York (S.L., P.R.G.); Albany Molecular Research, Inc., Albany, New York (D.D.M., N.A.M.); and Sargent Consulting, Hendersonville, North Carolina (B.J.S.)
The 5-hydroxytryptamine (5-HT) (serotonin) 5-HT receptor represents a clinical target for antagonists to deliver symptomatic relief to patients with diarrhea-predominant irritable bowel syndrome (IBS-d) or carcinoid syndrome. Unfortunately, this pharmacological strategy can present side effects (e.g. Read More