9,776 results match your criteria Male Urinary Organs


IgG4-Related Disease Complicated by Brain Parenchymal Lesions Successfully Treated with Corticosteroid Therapy: A Case Report.

Tohoku J Exp Med 2020 ;251(3):161-168

Department of Rheumatology, Fukushima Medical University School of Medicine.

Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is distinguished by the infiltration of IgG4-positive plasma cells in a variety of tissues and organs including the pancreas, salivary glands, retroperitoneal lesions, kidney, and lymph nodes with elevated serum IgG4 levels. Even so, central nervous system (CNS) lesions such as brain parenchymal lesions associated with IgG4-RD are scarce. So far, only six cases of IgG4-RD in relation with brain parenchymal lesions have been described, with its characteristics still being not clear. Read More

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http://dx.doi.org/10.1620/tjem.251.161DOI Listing
January 2020

Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse.

Ecotoxicol Environ Saf 2020 Jul 4;202:110902. Epub 2020 Jul 4.

Health Protection Research Unit, Wolfson Building, Newcastle University, Newcastle Upon Tyne, NE2 4AA, United Kingdom; Institute Translational and Clinical Research, Level 4 Leech, Newcastle University, Newcastle Upon Tyne, NE2 4HH, United Kingdom. Electronic address:

The ionic liquid 1-octyl-3-methylimidazolium (M8OI) has been found in the environment and identified as a hazard for triggering the liver disease primary biliary cholangitis (PBC). Given limited toxicity data for M8OI and other structurally-related ionic liquids, target organs for M8OI toxicity were examined. Adult male C57Bl6 mice were acutely exposed to 0-10 mg/kg body weight M8OI via 2 intraperitoneal injections (time zero and 18 h) and effects examined at 24 h. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110902DOI Listing

A rare case of herniated duplex collecting system causing obstructive uropathy.

BMC Urol 2020 Jul 1;20(1):83. Epub 2020 Jul 1.

Department of Medicine, St. Elizabeth's Medical Center, Boston, MA, USA.

Background: An inguinal hernia is the protrusion of intraabdominal organs through an opening in the abdominal wall. Structures such as small and large intestines are commonly contained within inguinal hernias. However, uretero-inguinal hernia of the native collecting system is an extremely rarely reported entity. Read More

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http://dx.doi.org/10.1186/s12894-020-00652-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329524PMC

Combined robotic and cystoscopic surgery for rectal cancer invading urinary bladder.

Int Cancer Conf J 2020 Jul 1;9(3):102-106. Epub 2020 Apr 1.

Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawara-cho, Sakyo-ku, Kyoto, 606-8507 Japan.

Although the application of laparoscopic rectal surgery has been widely accepted by accumulated evidence, it remains technically difficult in some cases of obesity, narrow male pelvis, bulky tumors, or involvement of adjacent organs. After robotic rectal surgery has been covered by the health insurance system in Japan since April 2018, we have employed robotic rectal surgery for an increasing number of cases by taking advantages of its 3D vision and wrist function. When a colorectal cancer involves the urinary bladder, the surgical treatment of choice is an anterior resection with en bloc (partial or total) bladder resection, depending on the site and extent of bladder involvement. Read More

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http://dx.doi.org/10.1007/s13691-020-00413-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297884PMC

A case of prostate stromal sarcoma involving the rectum.

J Surg Case Rep 2020 Jun 17;2020(6):rjaa165. Epub 2020 Jun 17.

Department of Organs Therapeutics, Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.

Sarcomas and related proliferative lesions of the specialized stroma of the prostate are very rare and have been classified into prostate stromal sarcoma (PSS) and prostatic stromal tumor of uncertain malignant potential based on histology. We herein describe a case of PSS. A 40-year-old male presented at a hospital with urinary distention. Read More

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http://dx.doi.org/10.1093/jscr/rjaa165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299605PMC

Evaluation of genitourinary fistulas in pelvic malignancies with etiopathologic correlation: role of cross sectional imaging in detection and management.

Br J Radiol 2020 Jul 15;93(1111):20200049. Epub 2020 Jun 15.

Department of Surgical Oncology, Basavatarakam Indo American Cancer Hospital & Research Institute, Road No 10, Banjara Hills, Hyderabad, Telangana, India, 500034.

Objective: Genitourinary fistulas in pelvic malignancies are abnormal communications occurring due to either locally advanced tumours invading the surrounding organs or post-therapeutic complications of malignancies. In this article we review and describe the role of cross-sectional imaging findings in the management of genitourinary fistulas in pelvic malignancies.

Methods: A retrospective study, for the period January 2012 to December 2018, was undertaken in patients with pelvic malignancies having genitourinary fistulas. Read More

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http://dx.doi.org/10.1259/bjr.20200049DOI Listing

The runaway kidney: a rare case of a parastomal hernia with partial kidney herniation.

J Surg Case Rep 2020 May 1;2020(5):rjaa067. Epub 2020 Jun 1.

Department of Surgery, Geisinger Community Medical Center, Scranton, PA, USA.

Although parastomal hernias are a common complication of ostomy formation, herniation of intra-abdominal organs, aside from intestine, is infrequent. Furthermore, herniation of retroperitoneal organs, such as the kidney, is an extremely rare finding. We report the case of a 59-year-old male with a right ileostomy who presented with an acute kidney injury with suggestive urinary tract infection. Read More

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http://dx.doi.org/10.1093/jscr/rjaa067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263757PMC

SARS-CoV-2 identification in lungs, heart and kidney specimens by transmission and scanning electron microscopy.

Eur Rev Med Pharmacol Sci 2020 05;24(9):5186-5188

Department of Excellence of Biomedical Sciences and Public Health, University "Politecnica delle Marche" of Ancona, Ancona, Italy.

From two COVID-19-related deaths, samples of lung, heart and kidney were collected and processed for Transmission and Scanning Electron Microscopy (TEM and SEM) with the aim of identifying the virus. Virions of SARS-CoV-2 were found in all tissues by TEM and SEM, corroborating the hypothesis that the virus enters the cells of different organs. This is the first report identifying SARS-CoV-2 in different human tissues by TEM and SEM. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21217DOI Listing

Correlation between amyloid deposits affecting renal compartments and glomerular filtration rate during renal biopsy in a renal amyloidosis case series.

Braz J Med Biol Res 2020 18;53(6):e8625. Epub 2020 May 18.

Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brasil.

Amyloidosis comprises a group of disorders that accumulate modified autologous proteins in organs, mainly the kidneys. Few studies have addressed the amyloid compartmental distribution and associated clinical outcomes. The aim of this study was to present a case series of renal amyloidosis correlating histopathological data with glomerular filtration rate (GFR) during kidney biopsy. Read More

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http://dx.doi.org/10.1590/1414-431x20208625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266501PMC

Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19.

Mol Biol Rep 2020 Jun 14;47(6):4383-4392. Epub 2020 May 14.

Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.

The ACE2 gene is a receptor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) for COVID-19 (coronavirus disease 2019). To analyze the expression profiles and clinical significances for this gene in humans, RNA-seq data representing 27 different tissues were analyzed using NCBI; total RNA was extracted from different tissues of mouse and semi-quantitative reverse transcriptional-polymerase chain reaction (Q-RT-PCR) was carried out. Immunohistochemistry expression profiles in normal tissues and cancer tissues and TCGA survival analysis in renal and liver cancer were conducted. Read More

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http://dx.doi.org/10.1007/s11033-020-05478-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224351PMC

COVID-19 occurring during Natalizumab treatment: a case report in a patient with extended interval dosing approach.

Mult Scler Relat Disord 2020 Jun 30;41:102165. Epub 2020 Apr 30.

NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London (UCL), London, UK; Department of Human Neuroscience, Sapienza University of Rome, Italy. Electronic address:

Background: The novel Coronavirus SARS-CoV-2, which was identified after a recent outbreak in Wuhan, China, in December 2019, has generated a global pandemic impacting over 200 countries around the world. Recent reports suggest that ACE2, which is the target protein to invade the host, has a ubiquitous presence in human organs, including lung parenchyma, gastrointestinal tract, nasal mucosa, renal and urinary tract, airway epithelia, lymphoid tissues, reproductive organs, vascular endothelium and neurons. In this scenario, neurologists are particularly involved into considering even more specific therapeutic strategies according to the available data during the pandemic. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191299PMC

Preclinical Incorporation Dosimetry of [F]FACH-A Novel F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET.

Molecules 2020 Apr 26;25(9). Epub 2020 Apr 26.

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, 04318 Leipzig, Germany.

Overexpression of monocarboxylate transporters (MCTs) has been shown for a variety of human cancers (e.g., colon, brain, breast, and kidney) and inhibition resulted in intracellular lactate accumulation, acidosis, and cell death. Read More

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http://dx.doi.org/10.3390/molecules25092024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248880PMC

Two novel deleterious variants of Angiotensin-I-converting Enzyme gene identified in a family with recurrent anhydramnios.

Mol Genet Genomic Med 2020 Jun 23;8(6):e1239. Epub 2020 Apr 23.

Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Anhydramnios results from the poor development of the placenta or problems with intrauterine development of the kidneys or urinary tract. Complete lack of amniotic fluid indicates a severe problem with the organs of the urinary system. The genes associated with anhydramnios show very diversity and are not yet well defined. Read More

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http://dx.doi.org/10.1002/mgg3.1239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284050PMC

Targeted Delivery of Therapeutics to Urological Cancer Stem Cells.

Curr Pharm Des 2020 ;26(17):2038-2056

College of Pharmacy, Southwest Minzu University, Chengdu, Sichuan, China.

Urological cancer refers to cancer in organs of the urinary system and the male reproductive system. It mainly includes prostate cancer, bladder cancer, renal cancer, etc., seriously threatening patients' survival. Read More

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http://dx.doi.org/10.2174/1381612826666200403131514DOI Listing
January 2020

[Effects of oral exposure to zinc oxide nanoparticles on the peripheral organs of C57BL/6J mice].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2019 Nov;35(6):555-558

Binzhou Medical College, Yantai 264000, China.

Objective: To investigate the effects of oral exposure of zinc oxide nanoparticles on multiple peripheral organs of C57BL/6J mice. ;Methods: Twenty male C57BL/6J mice were randomly divided into control group and experimental group, with 10 mice in each group. The experimental group was treated with continuous gavage administration of zinc oxide nanoparticle solution at a dose of 20 mg/kg body weight for 60 days, and the control group was given the corresponding amount of normal saline; the mice were weighed once a week. Read More

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http://dx.doi.org/10.12047/j.cjap.5859.2019.122DOI Listing
November 2019

Selenium prevents lithium accumulation and does not disturb basic microelement homeostasis in liver and kidney of rats exposed to lithium.

Ann Agric Environ Med 2020 Mar 12;27(1):129-133. Epub 2019 Apr 12.

Chair and Department of Medical Chemistry, Medical University, Lublin, Poland.

Introduction: Lithium has been used in medicine for almost seventy years. Besides beneficial effects, its therapy may cause serious side-effects, with kidney and liver being the organs most vulnerable to its harmful influence. Therefore, research on protective agents against lithium toxicity has been continuing for some time. Read More

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http://dx.doi.org/10.26444/aaem/105926DOI Listing

Ultra-Mini-Percutaneous Nephrolithotomy for the Treatment of Upper Urinary Tract Stones Sized between 10-20 mm in Children Younger Than 8 Years Old.

Urol J 2020 Mar 16;17(2):139-142. Epub 2020 Mar 16.

Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Purpose: With the invention of miniature devices, it has been advised to apply less aggressive methods for the management of upper urinary tract stones, especially in children. In the recent years, ultra-mini percutaneous nephrolithotomy (UMP) has been used for the treatment of upper urinary tract stones in order to perform surgeries with less complications and more acceptable outcomes. Results reported from different medical centers have been promising. Read More

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http://dx.doi.org/10.22037/uj.v0i0.5903DOI Listing
March 2020
0.707 Impact Factor

Characterization of six canine prostate adenocarcinoma and three transitional cell carcinoma cell lines derived from primary tumor tissues as well as metastasis.

PLoS One 2020 13;15(3):e0230272. Epub 2020 Mar 13.

Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover, Germany.

Canine prostate adenocarcinoma (PAC) and transitional cell carcinoma (TCC) of prostate and urinary bladder are highly invasive and metastatic tumors of closely neighbored organs. Cell lines are valuable tools to investigate tumor mechanisms and therapeutic approaches in vitro. PAC in dogs is infrequent, difficult to differentiate from TCC and usually characterized by poor prognosis, enhancing the value of the few available cell lines. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230272PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069630PMC

Changes in the gut microbiota of mice orally exposed to methylimidazolium ionic liquids.

PLoS One 2020 12;15(3):e0229745. Epub 2020 Mar 12.

Health Protection Research Unit, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, England, United Kingdom.

Ionic liquids are salts used in a variety of industrial processes, and being relatively non-volatile, are proposed as environmentally-friendly replacements for existing volatile liquids. Methylimidazolium ionic liquids resist complete degradation in the environment, likely because the imidazolium moiety does not exist naturally in biological systems. However, there is limited data available regarding their mammalian effects in vivo. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229745PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067480PMC

Clinical translation of F-fluoropivalate - a PET tracer for imaging short-chain fatty acid metabolism: safety, biodistribution, and dosimetry in fed and fasted healthy volunteers.

Eur J Nucl Med Mol Imaging 2020 Mar 2. Epub 2020 Mar 2.

Department of Surgery and Cancer, Imperial College London, GN1 Commonwealth Building, Hammersmith Hospital, DuCane Rd, London, W12 0NN, UK.

Background: Fatty acids derived de novo or taken up from the extracellular space are an essential source of nutrient for cell growth and proliferation. Radiopharmaceuticals including C-acetate, and F-FAC (2-F-fluoroacetate), have previously been used to study short-chain fatty acid (SCFA) metabolism. We developed F-fluoropivalate (F-FPIA; 3-F-fluoro-2,2-dimethylpropionic acid) bearing a gem-dimethyl substituent to assert metabolic stability for studying SCFA metabolism. Read More

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http://dx.doi.org/10.1007/s00259-020-04724-yDOI Listing

Updates in Histologic Grading of Urologic Neoplasms.

Arch Pathol Lab Med 2020 Mar;144(3):335-343

From the Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Context.—: Tumor histology offers a composite view of the genetic, epigenetic, proteomic, and microenvironmental determinants of tumor biology. As a marker of tumor histology, histologic grading has persisted as a highly relevant factor in risk stratification and management of urologic neoplasms (ie, renal cell carcinoma, prostatic adenocarcinoma, and urothelial carcinoma). Read More

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http://dx.doi.org/10.5858/arpa.2019-0551-RADOI Listing

Prenatal hypoxia increases susceptibility to kidney injury.

PLoS One 2020 21;15(2):e0229618. Epub 2020 Feb 21.

Department of Pediatrics, Division of Nephrology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

Prenatal hypoxia is a gestational stressor that can result in developmental abnormalities or physiological reprogramming, and often decreases cellular capacity against secondary stress. When a developing fetus is exposed to hypoxia, blood flow is preferentially redirected to vital organs including the brain and heart over other organs including the kidney. Hypoxia-induced injury can lead to structural malformations in the kidney; however, even in the absence of structural lesions, hypoxia can physiologically reprogram the kidney leading to decreased function or increased susceptibility to injury. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229618PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034911PMC

Evaluation of selected protein biomarkers of renal function in rats with an experimental model of acute cyclophosphamide-induced cystitis treated with N-acetylcysteine.

J Physiol Pharmacol 2019 Oct 30;70(5). Epub 2020 Jan 30.

Professor Emeritus at the Jagiellonian University Medical College, Cracow, Poland.

The administration of cyclophosphamide (CP) is associated with the risk of developing cystitis as well as kidney injury. The aim of the study was to verify the uroprotective effect of N-acetylcysteine (NAC), as well as the evaluation of renal function in the experimental model of acute CP-induced cystitis. Rats from group 1 received intraperitoneally only a single dose of 200 mg/kg b. Read More

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http://dx.doi.org/10.26402/jpp.2019.5.14DOI Listing
October 2019

[Cancers of urinary system, prevalence, demographic].

Urologiia 2019 12(6):74-77

Isfahan Kidney Transplantation Research Center.

Background: The aim of this study was to clarify period prevalence (PP) and incidence associated to urinary system cancers in Isfahan Province/Iran.

Method: s: Data from 2011 to 2015 was obtained from the Isfahan Cancer Registry. The location of cancers was distinguished by the related established topography code (C64-C68). Read More

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December 2019

ALK-rearranged renal cell carcinoma with a novel PLEKHA7-ALK translocation and metanephric adenoma-like morphology.

Virchows Arch 2020 Jun 28;476(6):921-929. Epub 2020 Jan 28.

Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, No. 201, Section 2, Shipai Road, Taipei, 11217, Taiwan.

ALK-rearranged renal cell carcinoma is a provisional entity in the 2016 WHO Classification of Tumors of the Urinary System and Male Genital Organs. The reported fusion partners included VCL, TPM3, EML4, STRN, and HOOK1. Herein, we present a peculiar renal cell carcinoma morphologically resembling metanephric adenoma and harboring a novel PLEKHA7-ALK fusion. Read More

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http://dx.doi.org/10.1007/s00428-020-02752-5DOI Listing

Systemic distribution of progesterone receptor subtypes in human tissues.

J Steroid Biochem Mol Biol 2020 May 25;199:105599. Epub 2020 Jan 25.

Department of Anatomic Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:

Progesterone receptor (PR) is expressed in a wide variety of human tissues, including both reproductive and non-reproductive tissues. Upon binding to the PR, progesterone can display several non-reproductive functions, including neurosteroid activity in the central nervous system, inhibition of smooth muscle contractile activity in the gastrointestinal tract, and regulating the development and maturation of the lung. PR exists as two major isoforms, PRA and PRB. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2020.105599DOI Listing

Dosimetric impact of organ at risk daily variation during prostate stereotactic ablative radiotherapy.

Br J Radiol 2020 Apr 30;93(1108):20190789. Epub 2020 Jan 30.

Department of Clinical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.

Objective: Prostate stereotactic ablative radiotherapy (SABR) delivers large doses using a fast dose rate. This amplifies the effect geometric uncertainties have on normal tissue dose. The aim of this study was to determine whether the treatment dose-volume histogram (DVH) agrees with the planned dose to organs at risk (OAR). Read More

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http://dx.doi.org/10.1259/bjr.20190789DOI Listing

Successful management of germanium poisoning-induced multiple organ dysfunctions by combined blood purification therapy.

Curr Med Res Opin 2020 Apr 5;36(4):687-691. Epub 2020 Feb 5.

Department of Organ Transplantation, Renmin Hospital, Wuhan University, Wuhan, China.

Blood purification therapy has not been applied in the detoxification of germanium compounds. This report described a case of germanium poisoning with renal failure, liver dysfunction, and acute pancreatitis which was successfully treated by continuous venovenous hemodiafiltration (CVVHDF) combined with plasmapheresis. A 58-year-old male was admitted to a local hospital due to polydipsia, polyuria, and weight loss for 2 months. Read More

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http://dx.doi.org/10.1080/03007995.2020.1717452DOI Listing

Impact of garlic (Allium sativum) oil on cisplatin-induced hepatorenal biochemical and histopathological alterations in rats.

Sci Total Environ 2020 Mar 28;710:136338. Epub 2019 Dec 28.

Chrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, F-25030 Besançon Cedex, France. Electronic address:

Cisplatin (cis-diamminedichloridoplatinum II [CDDP]) is a chemotherapeutic agent used for treating different cancers types. However, its usage is limited because it induces harmful toxicities in multiple organs, including nephrotoxicity and hepatotoxicity. Garlic oil (GO) has several pharmacological activities, including antioxidant activity. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.136338DOI Listing
March 2020
4.099 Impact Factor

In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats.

Int Neurourol J 2019 Dec 31;23(4):277-286. Epub 2019 Dec 31.

Department of Biochemistry, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Purpose: Alpha-1-adrenoceptor blockers (e.g., naftopidil) are prescribed for the treatment of male lower urinary tract symptoms. Read More

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http://dx.doi.org/10.5213/inj.1938102.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944793PMC
December 2019

A planning study of focal dose escalations to multiparametric MRI-defined dominant intraprostatic lesions in prostate proton radiation therapy.

Br J Radiol 2020 Mar 6;93(1107):20190845. Epub 2020 Jan 6.

Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta 30322, Georgia.

Objectives: The purpose of this study is to investigate the dosimetric effect and clinical impact of delivering a focal radiotherapy boost dose to multiparametric MRI (mp-MRI)-defined dominant intraprostatic lesions (DILs) in prostate cancer using proton therapy.

Methods: We retrospectively investigated 36 patients with pre-treatment mp-MRI and CT images who were treated using pencil beam scanning (PBS) proton radiation therapy to the whole prostate. DILs were contoured on co-registered mp-MRIs. Read More

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http://dx.doi.org/10.1259/bjr.20190845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066949PMC
March 2020
1.533 Impact Factor

Outcome of Kidney Transplantation Using Organs From Brain-dead Donors Older Than 75 Years.

Transplant Proc 2020 Jan - Feb;52(1):119-126. Epub 2019 Dec 31.

Department of Surgery, University Hospital Knappschaftskrankenhaus Bochum, Ruhr-University Bochum, Bochum, Germany. Electronic address:

Purpose: We investigated whether older donor kidneys aged >75 years have acceptable long-term function and if recipients can benefit sufficiently from the transplantation.

Methods: This single-center study retrospectively analyzed patient data from 217 deceased donor kidney transplants performed between 1998 and 2014 as part of the Eurotransplant Senior Program, where the organ donors were ≥65 years old. Depending on donor age, the groups "older donors" (OD; n = 161) and "very old donors" (VOD; n = 56) received transplants from donors aged 65 to 75 years and >75 years, respectively. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.11.013DOI Listing

Chronic NOS Inhibition Affects Oxidative State and Antioxidant Response Differently in the Kidneys of Young Normotensive and Hypertensive Rats.

Oxid Med Cell Longev 2019 22;2019:5349398. Epub 2019 Nov 22.

Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia.

Deficiency of nitric oxide (NO) and oxidative stress can be a cause, a consequence, or, more often, a potentiating factor for hypertension and hypertensive renal disease. Both NO and superoxide anions are radical molecules that interact with each other, leading to oxidative damage of such organs as the kidney. In the present study, we investigated the effect of chronic-specific (neuronal NOS inhibition) and nonspecific NOS inhibition on the oxidative state and antioxidant response and associated oxidative damage of the kidney of young normotensive and hypertensive rats. Read More

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http://dx.doi.org/10.1155/2019/5349398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893281PMC

Thallium exposure at low concentration leads to early damage on multiple organs in children: A case study followed-up for four years.

Environ Pollut 2020 Mar 21;258:113319. Epub 2019 Nov 21.

Center of Laboratory Medicine, Chongqing Prevention and Treatment Center for Occupational Diseases, Chongqing, People's Republic of China; Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College of Chongqing University, Chongqing, People's Republic of China. Electronic address:

Thallium (TI) is one of the most toxic heavy metals and priority pollutant metals. The emerging TI environmental pollution worldwide has posed a great threat to human health. However, based on the World Health Organization (WHO), the risk and severity of adverse health effects of TI in the range of 5-500 μg/L are uncertain. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.113319DOI Listing

Metachronous renal cell carcinoma with metastasis to the urinary bladder, and distant organs, 28 years after radical nephrectomy: a case report.

BMC Urol 2019 Dec 27;19(1):136. Epub 2019 Dec 27.

DSS Urology, Queens Village, New York, USA.

Background: Metachronous renal cell carcinoma after radical nephrectomy is extremely rare. Renal cell carcinoma commonly metastasizes to distant organs. However, metastasis to the urinary bladder is very uncommon. Read More

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http://dx.doi.org/10.1186/s12894-019-0521-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935093PMC
December 2019

Change of surfactant protein D and A after renal ischemia reperfusion injury.

PLoS One 2019 26;14(12):e0227097. Epub 2019 Dec 26.

Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea.

Acute kidney injury (AKI) is associated with widespread effects on distant organs, including the lungs. Surfactant protein (SP)-A and SP-D are members of the C-type lectin family, which plays a critical role in host defense and regulation of inflammation in a variety of infections. Serum levels of SP-A and SP-D are markers to reflect lung injury in acute respiratory distress syndrome, idiopathic pulmonary fibrosis, and sarcoidosis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227097PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932791PMC

Computed tomography imaging characteristics of clear cell papillary renal cell carcinoma.

Int Braz J Urol 2020 Jan-Feb;46(1):26-33

Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.

Purpose: Clear cell papillary (CCP) renal cell carcinoma (RCC) is a new subtype of RCC that was formally recognized by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia in 2013. Subsequently, CCP RCC was added to the 2016 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs. In this study, we retrospectively investigated the computed tomography (CT) findings of pathologically diagnosed CCP RCC. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0716DOI Listing
February 2020
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Clinical Manifestation, Distribution, and Drug Resistance of Pathogens Among Abdominal Solid Organ Transplant Recipients With Klebsiella pneumoniae Infections.

Transplant Proc 2020 Jan - Feb;52(1):289-294. Epub 2019 Dec 16.

Department of Transplant Surgery, the Third Xiangya Hospital of Central South University, Changsha, China. Electronic address:

Background: A Klebsiella pneumoniae infection is a life-threatening disease among abdominal solid organ transplant (ASOT) recipients. The objectives of our present work are to investigate the distribution and drug resistance of pathogens, and clinical manifestation among ASOT recipients suffering from K pneumoniae infections.

Methods: The medical records of 53 ASOT recipients with 63 episodes of K pneumoniae infections from October 1, 2013 to June 1, 2019 were reviewed according to the Declaration of Helsinki and the Declaration of Istanbul. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.11.023DOI Listing

The Effect of Cyclosporine and the Consequences in Hepatic and Renal Function Following Ischemic Stroke in a Rats' Model.

J Stroke Cerebrovasc Dis 2020 Feb 11;29(2):104562. Epub 2019 Dec 11.

Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School of Athens, National and Kapodistrian University of Athens, Athens, Greece.

Introduction: Recent studies have indicated that the damaging effects of stroke are not only limited to the brain. We sought to examine the changes of liver and renal enzymes in the acute phase of ischemic stroke and to investigate possible explanations and therapeutic options, concerning in particular the functional alterations of peripheral organs after administration of an anti-inflammatory agent.

Material/methods: Twelve-week-old Wistar male rats were randomly divided into control and Cyclosporine groups (n = 10 each). Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.104562DOI Listing
February 2020

Biodistribution, Clearance And Morphological Alterations Of Intravenously Administered Iron Oxide Nanoparticles In Male Wistar Rats.

Int J Nanomedicine 2019 6;14:9677-9692. Epub 2019 Dec 6.

School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India.

Introduction: Nanoparticles are used worldwide because of their unique properties, with large-scale application in various fields, such as medicine, cosmetics and industries. In view of their widespread use, the potential adverse effects of nanoparticles have become a significant cause for concern, in terms of not only human health and safety but also the environment. The present investigation focused on establishing the bioaccumulation patterns and ultrastructural changes induced by retained iron oxide nanoparticles (IONPs) in various target organs of rats. Read More

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http://dx.doi.org/10.2147/IJN.S223142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902883PMC

Salt intake assessed by spot urine on physical examination in Hunan, China.

Asia Pac J Clin Nutr 2019 ;28(4):845-856

Department of Health Management, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background And Objectives: Excessive salt intake is a major public health problem in several countries, especially in China. However, few people are aware of their salt intake. The purpose of this study is to carry out salt intake test in routine physical examination, and to explore the salt intake of different populations and their correlation with diet. Read More

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http://dx.doi.org/10.6133/apjcn.201912_28(4).0022DOI Listing

Pomegranate Juice Diminishes The Mitochondria-Dependent Cell Death And NF-kB Signaling Pathway Induced By Copper Oxide Nanoparticles On Liver And Kidneys Of Rats.

Int J Nanomedicine 2019 15;14:8905-8922. Epub 2019 Nov 15.

Pathology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Background: Pomegranate ( L) has been used since ancient times in the traditional medicine of several cultures, particularly in the Middle East. It is an essential commercial crop full of bioactive compounds with several medical applications. Pomegranate is very popular for its biological effects exerted by phenolic compounds via free radical scavenging abilities. Read More

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http://dx.doi.org/10.2147/IJN.S229461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863130PMC
February 2020

Comparative biochemical and histopathological evaluations proved that receptacle is the most effective part of Cynara scolymus against liver and kidney damages.

J Ethnopharmacol 2020 Mar 4;249:112458. Epub 2019 Dec 4.

Yeditepe University, Faculty of Pharmacy, Department of Pharmacognosy and Phytotherapy, Ataşehir, 34755, İstanbul, Turkey. Electronic address:

Ethnopharmacological Relevance: The liver and kidney are among the most important organs in the body, where metabolic and elimination functions take place. During this process, liver and kidneys may suffer damage due to ingestion or formation of toxic metabolites leading to organ loss and even death. Artichoke (Cynara scolymus L. Read More

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http://dx.doi.org/10.1016/j.jep.2019.112458DOI Listing

[Experimental evaluation of inflammatory process in the prostate caused by transurethral transmission of uropathogen in low counts].

Urologiia 2019 Dec(5):14-21

Department of Urology and Human Reproductive Health with the course of Pediatric Urology-andrology of the Advanced Training and Specialist Professional Retraining Faculty FGBOU VO Rostov State Medical University of Russian Federation Ministry of Health, Rostov-on-Don, Russia.

Background: According to the literature, bacterial count of uropathogens isolated from expressed prostate secretion and urine which is sufficient for a diagnosis of bacterial prostatitis I and II categories, remains contradictory. Undoubtedly, the identification of microorganisms from affected organ in high titers indicates the presence of a relevant infectious-inflammatory process. In turn, there is no consensus on the development of bacterial prostatitis at lower titers of uropathogens. Read More

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December 2019

Metastatic non-muscle invasive bladder can-cer with cervical lymph node metastasis.

Int Braz J Urol 2019 Nov-Dec;45(6):1270-1274

Department of Urology, Hospital Universitario del Henares, Coslada, Universidad Francisco de Vitoria, Madrid, Spain.

Bladder cancer is a common cancer that may present as superficial, invasive, or metastatic disease. Non-muscle-invasive bladder cancer (NMIBC) represents the majority of bladder cancer diagnoses, but represents a spectrum of disease with a variable clinical course, notably for significant risk of recurrence and potential for progression. NMIBC metastasis to distant organs without local invasion or regional metastasis is a very rare occurrence, so there are limi-ted case reports about early metastasis in the literature. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0421DOI Listing
January 2020

Ultrasonographic appearance of the coelomic cavity organs in healthy veiled chameleons (Chamaeleo calyptratus) and panther chameleons (Furcifer pardalis).

Vet Radiol Ultrasound 2020 Jan 3;61(1):58-66. Epub 2019 Dec 3.

Fundació Hospital Clínic Veterinari. Carrer de l'Hospital, Bellaterra (Cerdanyola del Vallès), Barcelona, Spain.

Veiled chameleons (Chamaeleo calyptratus) and panther chameleons (Furcifer pardalis) are the most popular chameleons over the world, and consequently, two of the most frequent species presenting to veterinary practices. However, published studies on normal ultrasonographic anatomy for these lizards are currently lacking. The objectives of this prospective anatomic study were to develop an ultrasound protocol for evaluation of the coelomic cavity in these species and describe the normal ultrasonographic anatomy of the coelomic organs. Read More

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http://dx.doi.org/10.1111/vru.12820DOI Listing
January 2020

Cold Renal Perfusion During Simulation of Juxtarenal Aortic Aneurysm Repair Reduces Systemic Oxidative Stress and Sigmoid Damage in Rats.

Eur J Vasc Endovasc Surg 2019 Dec;58(6):891-901

Amsterdam University Medical Centres, Location VUmc, Department of Surgery, Amsterdam, the Netherlands; Amsterdam University Medical Centres, Location VUmc, Department of Physiology, Amsterdam, the Netherlands. Electronic address:

Objectives: Juxtarenal aortic surgery induces renal ischaemia reperfusion, which contributes to systemic inflammatory tissue injury and remote organ damage. Renal cooling during suprarenal cross clamping has been shown to reduce renal damage. It is hypothesised that renal cooling during suprarenal cross clamping also has systemic effects and could decrease damage to other organs, like the sigmoid colon. Read More

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http://dx.doi.org/10.1016/j.ejvs.2019.05.021DOI Listing
December 2019