Search Our Scientific Publications & Authors

Neurourol Urodyn 2018 Aug;37(S6):S32-S38

Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

Aims: Chronic pelvic pain (CPP) is defined as a noncyclical pain that has duration of at least 6 months and can lead to decreased quality of life and physical performance. The pain can be attributed to problems in the pelvic organs and/or problems in related systems, and possible psycho-social attributes may contribute to the manifestation. Due to the complex nature, CPP syndromes are multifactorial and the terminology needs to reflect the setting. Read More

Vet J 2019 Jan 30;243:82-90. Epub 2018 Nov 30.

Department of Clinical Bacteriology and Mycology, The Kimron Veterinary Institute, Bet Dagan, Israel. Electronic address:

Disseminated canine mold infections are reviewed. Case inclusion criteria were dogs as hosts, two or more non-adjacent organs affected and identification of the etiological agent at least to the genus level. Of the 157 cases identified, 59. Read More

Medicine (Baltimore) 2018 Dec;97(52):e13638

Department of Internal Medicine, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

Rationale: Crystal sorting histiocytosis (CSH) is a rare disorder that is morphologically characterized by the accumulation of monoclonal immunoglobulin crystals, predominantly of a kappa light chain type, within lysosomes of macrophages. CSH may result in a variety of clinical manifestations depending on the involved organs. In this case report, we aim to describe a patient with ophthalmic manifestations which lead to the diagnosis of multiple myeloma with crystal-storing histiocytosis, crystalline podocytopathy, and light chain proximal tubulopathy. Read More

Swiss Med Wkly 2018 12 21;148:w14699. Epub 2018 Dec 21.

Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.

Background And Aim: Wilson’s disease is an inherited disorder of hepatic copper metabolism, leading to the accumulation of copper in the liver as well as the brain, cornea and other organs. Here, we describe the adult cases of hepatic Wilson’s disease diagnosed at the Division of Gastroenterology and Hepatology of the University Hospital Lausanne, Switzerland between September 2004 and August 2016.

Methods: Clinical manifestations, results of diagnostic tests, management and outcomes of adult patients with hepatic Wilson’s disease were assessed based on standardised medical records. Read More

Histopathology 2019 Jan;74(1):4-17

Aquesta Uropathology, Brisbane, Qld, Australia.

Grading of renal cell carcinoma (RCC) has been recognised as a prognostic factor for almost 100 years. Numerous grading systems have been proposed, initially focusing upon a constellation of cytological features and more recently on nuclear morphology. It has been recommended that grading of RCC should be based upon nucleolar prominence/eosinophilia for grades 1-3, while grade 4 requires nuclear anaplasia (including tumour giant cells, sarcomatoid differentiation and/or rhabdoid morphology). Read More

Histopathology 2019 Jan;74(1):77-96

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Pathological evaluation of bladder cancer typically reveals great tumour heterogeneity, and therefore the common observation of urothelial carcinoma exhibiting a wide variety of histopathological patterns is not surprising. Some of these patterns are so distinctive that they have been recognised as specific variants of urothelial carcinoma. Classifications have recently been revised in the 2016 World Health Organisation (WHO) classification of tumours of the urinary system and male genital organs. Read More

Ann Occup Environ Med 2018 14;30:69. Epub 2018 Dec 14.

1Department of Occupational & Environmental Medicine, Eulji University Hospital, Daejeon, Republic of Korea 35233.

Objective: Kidneys are organs having a biological clock, and it is well known that the disruption of the circadian rhythm increases the risk of chronic kidney disease (CKD), including the decline of renal and proteinuria. Because shift work causes circadian disruption, it can directly or indirectly affect the incidence of chronic kidney disease. Therefore, the purpose of this study was to investigate the association between shift work and chronic kidney disease using a Korean representative survey dataset. Read More

Phys Med 2018 Dec 22;56:41-49. Epub 2018 Nov 22.

Department of Nuclear Medicine, Institut Jules Bordet-Université Libre de Bruxelles (ULB), 121 boulevard de Waterloo, 1000 Brussels, Belgium. Electronic address:

Purpose: Peptide receptor radionuclide therapy with Lu-DOTATATE has become a standard treatment modality in neuroendocrine tumours (NETs). No consensus has yet been reached however regarding the absorbed dose threshold for lesion response, the absorbed dose limit to organs-at-risk, and the optimal fractionation and activity to be administered. This is partly due to a lack of uniform and comparable dosimetry protocols. Read More

Urol Case Rep 2019 Mar 15;23:10-12. Epub 2018 Nov 15.

Department of Surgery - Division of Urology, 1 Hospital Drive, MC 301E, Columbia, MO, 65212, USA.

A 61-year-old male presented with gross hematuria and transurethral resection of bladder tumor revealed inflammatory myofibroblastic tumor (IMT). Due to extent of disease leading to ureteral obstruction and hydronephrosis, radical cystectomy (RC) with ileal conduit urinary diversion was performed. Five months after RC, the patient presented with decreased urine output. Read More

Surg Pathol Clin 2018 Dec;11(4):837-876

Departments of Pathology and Urology, VCU School of Medicine, 1200 East Marshall Street, PO Box 980662, Richmond, VA 23298, USA. Electronic address:

Mesenchymal neoplasms of the genitourinary (GU) tract often pose considerable diagnostic challenges due to their wide morphologic spectrum, relative rarity, and unexpected incidence at GU sites. Soft tissue tumors arise throughout the GU tract, whether from adventitia surrounding or connective tissues within the kidneys, urinary bladder, and male and female genital organs. This selected article focuses on a subset of these lesions, ranging from benign to malignant and encompassing a range of patterns of mesenchymal differentiation, where recent scholarship has lent greater insight into their clinical, molecular, or diagnostic features. Read More

Pathologe 2018 Nov 16. Epub 2018 Nov 16.

Department of Pathology, Medical University Innsbruck, Müllerstraße 44, 6020, Innsbruck, Austria.

The most frequent anomaly of the urogenital tract is a simple renal ectopia with one organ lying in the pelvis. Crossed renal ectopia is a less common condition in which the ectopic kidney is located on the opposite side of the midline from the ureteral insertion in the urinary bladder. The cause of both types of renal ectopia is the arrest or failure of the kidney ascent from the pelvic to the lumbar position. Read More

Urol Ann 2018 Oct-Dec;10(4):400-405

Department of Urology and Transplantation Surgery, Institute of Kidney Disease and Research Centre, Dr. H.L. Trivedi Institute of Transplant Sciences, Civil Hospital Campus, Ahmedabad, Gujarat, India.

Objective: Retroperitoneoscopy, by avoiding peritoneal breach and injury to intra-abdominal organs, provides a more direct and rapid access to the kidney and the renal hilum. Laparoscopic partial nephrectomy by retroperitoneal route (LPNR) is less commonly performed than transperitoneal route for early stage renal cancer. The objective of this study is to carry out the outcomes of partial nephrectomy using retroperitoneal approach. Read More

Med Sci Monit 2018 Oct 31;24:7794-7801. Epub 2018 Oct 31.

Faculty of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, China (mainland).

BACKGROUND Renal ischemic-reperfusion (RIR) injury remains a major cause of acute kidney injury, with increased in-hospital mortality and risks for chronic kidney disease. Previous studies have proposed that oxidative stress, inflammation, and renal apoptosis are the most common causes of injury, whereas recent research proved that methane, the simplest alkane generated by an enteric microorganism or accompanying the production of reactive oxygen species (ROS), can alleviate inflammation and oxidative stress and reduce apoptosis in different organs. MATERIAL AND METHODS In the present study, we analyzed the possible effects of methane-rich saline in RIR injury in a mouse model and analyzed its possible protective effects on inflammation, oxidative stress, and apoptosis. Read More

Cancer Radiother 2018 Dec 12;22(8):754-762. Epub 2018 Oct 12.

Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, 05505 Songpa-gu, Seoul, Republic of Korea.

Purpose: Stereotactic body radiation therapy is a promising treatment modality for locally advanced pancreatic cancer. To determine the optimal radiation treatment, we compared the plan characteristics of volumetric-modulated arc therapy and intensity-modulated radiation therapy when administered with stereotactic body radiation therapy to treat pancreatic cancer.

Patients And Methods: Fifteen patients with locally advanced pancreatic cancer were treated by stereotactic body radiation therapy at a dose of 24-32Gy in four fractions with marker-guided gated volumetric-modulated arc therapy. Read More

Pharmacol Rep 2018 Dec 29;70(6):1097-1104. Epub 2018 May 29.

Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland. Electronic address:

Background: Mephedrone is a recreationally used synthetic cathinone, relatively new abusive substances with molecular structure similar to amphetamine. As there is still lack of scientific data regarding mechanisms of action as well as metabolism of mephedrone, especially in aspects other than neurotoxicity, addiction or behavioral changes, therefore we aimed, for the first time, to investigate potential pro-oxidative actions of a single dose of mephedrone in organs other than brain and its structures, i.e. Read More

Annu Rev Anim Biosci 2018 Oct 10. Epub 2018 Oct 10.

Physiological Chemistry, Biocenter, University of Würzburg, D-97074 Würzburg, Germany; email:

In vertebrates, sex organs are generally specialized to perform a male or female reproductive role. Acquisition of the Müllerian duct, which gives rise to the oviduct, together with emergence of the Amh/Amhr2 system favored evolution of viviparity in jawed vertebrates. Species with high sexspecific reproductive adaptations have less potential to sex reverse, making intersex a nonfunctional condition. Read More

Ecotoxicol Environ Saf 2019 Jan 5;167:60-68. Epub 2018 Oct 5.

Department of Plant Protection, Faculty of Agriculture, Zagazig University, El-Sharkia Province, Egypt.

Available data regarding Imidacloprid (IMI) insecticide hazards to birds are still being scare. Our study aimed to investigate toxic impacts of IMI oral gavage by different dose levels on the brain and liver of Rock pigeon (Columba livia domestica). Forty mature male birds were divided equally into four groups. Read More

Top Magn Reson Imaging 2018 Oct;27(5):335-352

Department of Radiology, Mayo Clinic, Rochester, MN.

Increasing clinical experience and ongoing research in the field of magnetic resonance elastography (MRE) is leading to exploration of its applications in other abdominal organs. In this review, the current research progress of MRE in prostate, uterus, pancreas, spleen, and kidney will be discussed. The article will describe patient preparation, modified technical approach including development of passive drivers, modification of sequences, and inversion. Read More

Food Chem Toxicol 2018 Dec 25;122:80-86. Epub 2018 Sep 25.

Division of Pathology, National Institute of Health Sciences, Japan.

5-Hexenyl isothiocyanate (5-HeITC) is a naturally derived flavoring substance from Wasabia japonica. To clarify the toxicological profile of 5-HeITC, we performed a subchronic toxicity study of 5-HeITC with intragastric administration at daily doses of 0, 3, 12, or 48 mg/kg body weight (BW) to 6-week-old male and female F344/DuCrj rats for 13 weeks. Body weight gain was decreased in the male 48 mg/kg BW group. Read More

J Trace Elem Med Biol 2018 Dec 26;50:305-311. Epub 2018 Jul 26.

School of Interdisciplinary Science, McMaster University, Hamilton, ON, L8S 4K1 Canada.

There exists a need for accurate, non-invasive point-of-care tests to detect body iron burden. This study investigated the use of x-ray fluorescence (XRF) measurements of skin iron as a marker for organ iron content in rats. This study also evaluated a novel application of a commercial XRF device, commonly used in mining and construction, as a rapid, portable, and non-invasive measurement tool. Read More

J Nippon Med Sch 2018 ;85(4):204-207

Department of Urology (Chief: S. Kurita), Tachikawa Sogo Hospital.

Objectives: To evaluate the efficacy of early transcatheter arterial embolization for hemodynamically stable patients with The American Association for the Surgery of Trauma (AAST) grade 4 blunt renal trauma.

Materials And Methods: The medical records of consecutive patients with grade 4 blunt renal trauma who were transported to our two critical care centers in Japan and treated with early transcatheter arterial embolization (TAE) between 2001 and 2013 were retrospectively reviewed. Treatment failure was defined as the need for further surgical intervention or re-embolization after initial embolization. Read More

Mol Imaging Biol 2018 Sep 24. Epub 2018 Sep 24.

Center for Molecular Imaging and Therapy, Biomedical Research Foundation, Shreveport, LA, 71103, USA.

Purpose: 4-[F]Fluorobenzylguanidine ([F]PFBG) is a positron emission tomography (PET) probe for non-invasive targeting of the norepinephrine transporter. The aim of this study was to assess uptake and distribution characteristics of this PET probe.

Procedures: Three cynomolgus monkeys were injected with 269 ± 51 MBq (7. Read More

J Ethnopharmacol 2019 Jan 12;228:1-10. Epub 2018 Sep 12.

Department of Pharmacology and Toxicology, University of Benin, Benin city, Nigeria.

Ethnopharmacological Relevance: Parkia biglobosa seeds are used to treat diabetes and complications hence this study.

Aim: This study investigated the effects of Parkia biglobosa aqueous seed extract on some biochemical, haematological and histopathological indices in streptozotocin-induced diabetic rats.

Materials And Methods: Wistar rats of either sex (180-300 g) were fasted overnight and diabetes mellitus induced using streptozotocin 40 mg/kg IP. Read More

Med Phys 2018 Nov 1;45(11):4793-4805. Epub 2018 Oct 1.

Department of Radiology, Turku University Hospital, Kiinamyllynkatu 4-8, 20521, Turku, Finland.

Purpose: Transurethral ultrasound therapy is an investigational treatment modality which could potentially be used for the localized treatment of prostate cancer. One of the limiting factors of this therapy is prostatic calcifications. These attenuate and reflect ultrasound and thus reduce the efficacy of the heating. Read More

Acta Cir Bras 2018 Aug;33(8):713-722

MD, Holy House of Mercy of Fortaleza, Fortaleza-CE, Brazil. Conception and design of the study, technical procedures, interpretation and analysis of data, critical revision, final approval.

Purpose: To develop a model and curriculum for simulated training of an effective and well accepted laparoscopic vesicourethral anastomosis (VUA).

Methods: Experimental longitudinal study of quantitative character. The sample consisted of 12 general surgery residents and 6 urology residents (R3). Read More

Georgian Med News 2018 Jul-Aug(280-281):129-134

Karaganda State Medical University; National Scientific Center of Oncology and Transplantology, Astana, Kazakhstan; Medical Center Shaarei Tzedek, Jerusalem, Israel.

To this day, limiting the amount of sampling of donor tissue and organs, tissue rejection issues and numerous possible complications remain unresolved problems and are an actual problem of practical urology. This provision indicates the existence of a need to find alternative methods for solving this problem. The aim of the study was to study and compare the morphometric values of various types of implants with the tissue of the kidneys of rats in the early periods. Read More

Dev Biol 2018 11 3;443(1):78-91. Epub 2018 Sep 3.

Department of Medicine, Renal Research Institute, New York Medical College, Valhalla, NY, United States; Department of Physiology, Renal Research Institute, New York Medical College, Valhalla, NY, United States. Electronic address:

Maternal undernutrition during pregnancy (MUN) often leads to low birth weight (LBW) neonates that have a reduced total nephron endowment, leaving these neonates susceptible to kidney disease throughout their lives. For reasons unknown, these LBW neonates have impaired kidney development due to a severe reduction in renal SIX2 stem cells during nephrogenesis. Using a mouse model of MUN, we investigated SIX2 stem cell reduction in the LBW neonate. Read More

Case Rep Gastroenterol 2018 May-Aug;12(2):453-456. Epub 2018 Aug 21.

Department of Gastroenterology, Saint George Hospital University Medical Center, University of Balamand, Beirut, Lebanon.

Malakoplakia is a rare chronic granulomatous disease that may affect many organs, including the lung, brain, adrenal glands, pancreas, bone, and the genitourinary tract. The gastrointestinal tract is the most common site of involvement outside of the urinary tract. Herein, we present a case of a 65-year-old male who presented with abdominal pain and unintentional weight loss. Read More

Int J Artif Organs 2018 Sep 5:391398818796346. Epub 2018 Sep 5.

2 Department of Internal Nephrology, University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.

Late ureteral stenosis following kidney transplantation needs immediate correction in order to protect allograft function and requires a complicated surgical procedure. In this study, we present the long-term results of tubular bladder reconfiguration and cystopyelostomy (tubular vesicopyelostomy), an innovative and practical procedure for the management of long-segment ureteric stenosis (types 2 and 3) after transplantation. Between 2002 and 2017, 722 kidney transplant patients were monitored at the University of Medical Sciences, Bozyaka Organ Transplantation and Research Center. Read More

J Enzyme Inhib Med Chem 2018 Dec;33(1):1392-1404

b Department of Pharmaceutical Sciences , Università degli Studi di Milano , Milan , Italy.

The synthesis of a new dithiolethione-cysteine ethyl ester hybrid, ACS94, its metabolites, and its effect on GSH levels in rat tissues and on the concentration of circulating HS is described. ACS94 rapidly enters the cells, where it is metabolised to cysteine and the dithiolethione moiety ACS48. Experiments performed through the oral administration of ACS94 to healthy rats showed that it is capable of increasing the GSH levels in most of the analysed organs and the concentration of circulating HS. Read More

Pathologe 2018 Sep;39(5):415-423

Institut für Pathologie, Universität Innsbruck, Müllerstraße 44, 6020, Innsbruck, Österreich.

The most frequent anomaly of the urogenital tract is a simple renal ectopia with one organ lying in the pelvis. Crossed renal ectopia is a less common condition in which the ectopic kidney is located on the opposite side of the midline from the ureteral insertion in the urinary bladder. The cause of both types of renal ectopia is the arrest or failure of the kidney ascent from the pelvic to the lumbar position. Read More

Biomed Pharmacother 2018 Oct 31;106:1767-1774. Epub 2018 Jul 31.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Background: Cisplatin is widely used in the chemotherapy of solid organ cancers. However, its application is associated with serious side effects in various organs including the kidneys and liver.

Objectives: The aim of this study was to investigate the effects of mallow extract on the side effects of cisplatin in the kidneys and liver. Read More

Curr Pediatr Rev 2018 ;14(4):219-226

Medecine Neonatale, Hopital La Conception, APHM, Aix-Marseille Universite, Marseille, France.

Background: Cardiovascular and chronic kidney diseases are a part of noncommunicable chronic diseases, the leading causes of premature death worldwide. They are recognized as having early origins through altered developmental programming, due to adverse environmental conditions during development. Preterm birth is such an adverse factor. Read More

Anticancer Res 2018 Aug;38(8):4759-4766

Department of Pathology, School of Medicine, University of Yamanashi, Chuo, Japan.

Background/aim: Immunohistochemistry was used to evaluate 600 carcinomas of major histological types from various organs to determine the tissue distributions of the novel markers prostein, uroplakin II and SATB2.

Materials And Methods: We retrieved 30 cases from 20 different carcinomas of systemic organs.

Results: All prostate adenocarcinomas were immunopositive for prostein, and its reactivity was consistently diffuse. Read More

ScientificWorldJournal 2018 2;2018:2494918. Epub 2018 Jul 2.

Department of Bioscience and Oral Diagnosis, São Jose dos Campos Institute of Science and Technology, Universidade Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos 12245-000, SP, Brazil.

Chronic alcohol exposure can affect the osteoblastic activity and the proliferation and differentiation of cells due to its toxic effect, which can affect negatively bone repair and bone microarchitecture. The aim of this study was to evaluate the effects of chronic use of 20% alcohol on rats regarding osteoblastic differentiation, extrinsic and intrinsic properties of the tibia, and hepatic and renal morphology. Wistar rats were divided into three groups ( = 9) in accordance with a 24-week diet. Read More

Transplant Proc 2018 Jul - Aug;50(6):1881-1888. Epub 2018 Mar 14.

Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Poland.

Background: Incidence of malignancy in transplant recipients is higher than in the general population. Malignancy is a major cause of mortality following solid organ transplantation and a major barrier to long-term survival for the kidney. The aim of this study was to estimate the incidence of solid organ malignancy (SOM) and melanoma in renal transplant recipients (RTR) transplanted at 2 representative transplant centers in Poland based on data from the Polish Tumor Registry. Read More

Transplant Proc 2018 Jul - Aug;50(6):1691-1696. Epub 2018 Mar 14.

Department of Emergency Medicine, Warsaw Medical University, Warsaw, Poland.

Kidney transplant (KTx) is the best method of renal insufficiency treatment. In dialyzed patients, mortality rises with the time on dialysis. There is a continuing shortage of organs for transplantation, hence a propensity to expand the donor pool with expanded-criteria donors, anti-hepatitis C virus-positive included. Read More

Transplant Proc 2018 Jul - Aug;50(6):1680-1685. Epub 2018 Mar 13.

Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland.

Background: Despite an increasing utilization of kidneys procured from expanded-criteria donors, little is known about the effects of particular expanded-criteria donors definition components, that is, hypertension, increased creatinine prior to procurement, and cerebrovascular cause of death on the kidney graft Doppler parameters measured shortly after transplantation, whose increased values are associated with unfavorable outcomes. Hence, we analyzed the relationship between expanded-criteria donors components and resistance index values measured within 2 to 3 days post-transplant.

Material And Methods: The initial post-transplant resistance index value was measured in 676 consecutive successful first cadaveric kidney graft recipients without delayed graft function or early acute rejection episode. Read More

Transplant Proc 2018 Jul - Aug;50(6):1669-1673. Epub 2018 Mar 28.

Department of General and Transplantation Surgery, Orlowski Transplantation Institute, Medical University of Warsaw, Warsaw, Poland.

Background: Multiple renal artery kidneys still represent a special challenge for surgeons, during both nephrectomy for organ donation and transplantation. Recognition of anatomical conditions with advanced imaging methods is one of the most important elements of the preoperative evaluation process.

Aim: The purpose of the current study was to assess if anatomical abnormalities affect the outcomes of living kidney donor transplantation procedures. Read More

Int J Legal Med 2018 Nov 28;132(6):1735-1741. Epub 2018 Jul 28.

Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.

Objectives: Diffusion-weighted MRI provides information regarding body water movement following death, which may be an imaging marker of post-mortem interval (time since death; PMI) or maceration (degree of tissue degradation during intra-uterine retention) in perinatal deaths. Our aim was to evaluate the relationship between maceration, PMI and body organ apparent diffusion coefficient (ADC) values in a cohort of subjects across a wide gestational range.

Materials: Whole body post-mortem MRI with diffusion-weighted imaging (DWI) sequences were performed at 1. Read More

Arch Pathol Lab Med 2018 Jul 25. Epub 2018 Jul 25.

From the Department of Pathology, University of Texas MD Anderson Cancer Center, Houston (Dr Wang); and the Robert J. Tomsich Pathology and Laboratory Medicine Institute, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio (Dr McKenney).

Context: - Since the publication of the previous World Health Organization (WHO) Classification of Tumours on the Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs in 2004, significant new knowledge has been generated regarding the pathology and genetics of bladder neoplasia. Publication of the 2016 WHO "Blue Book" has codified that new data into updated recommendations for classification and prognostication. Similarly, the recent release of the 8th edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual, which was implemented in January 2018, has also addressed staging criteria for bladder cancer in several unique settings to clarify their application. Read More

Indian J Urol 2018 Jul-Sep;34(3):223-225

Department of Radiodiagnosis, SGRR Institute of Medical and Health Sciences, Dehradun, Uttarakhand, India.

Urinary bladder and the rectum share a common embryological origin, and the anatomical proximity of these two organs suggest that a dysfunction in either may influence the function of the other. Although, the coexistence of bladder and bowel dysfunction has been previously reported in the literature, there are hardly any reports on coexistence of posterior urethral valve (PUV) with Hirschsprung's disease. Here, we report a case of a 20-month-old male child who was initially treated for PUV and was later found to have coexisting Hirschsprung's disease. Read More

Gan To Kagaku Ryoho 2018 Jun;45(6):973-975

Dept. of Surgery, Nagoya Ekisaikai Hospital.

A 66-year-old man was referred to our hospital after being diagnosed with a pelvic tumor. A subsequent transperineal biopsy revealed spindle cells with CD34·c-kit(+). An enhanced computed tomography scan showed a giant rectal-derived tumor in the pelvis. Read More

PLoS One 2018 17;13(7):e0197757. Epub 2018 Jul 17.

Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background And Purpose: Incontinence, hematuria, voiding frequency and pain during voiding are possible side effects of radiotherapy among patients treated for prostate cancer. The objective of this study was to develop multivariable NTCP models for these side effects.

Material And Methods: This prospective cohort study was composed of 243 patients with localized or locally advanced prostate cancer (stage T1-3). Read More

J Ethnopharmacol 2018 Oct 2;225:81-89. Epub 2018 Jul 2.

Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address:

Ethnopharmacological Relevance: Aristolochia manshuriensis Kom (AMK), belonging to the Aristolochia family, is traditionally used in China to remove heart fire, promote dieresis, restore menstruation, and enhance milk secretion. The active constitutes of AMK are aristolochic acids (AAs, I and II) that are reported to cause serious side effects including nephrotoxicity and carcinogenicity.

Aim Of The Study: The tumorigenic role of AMK is far to be understood. Read More

Biomed Res Int 2018 21;2018:3576157. Epub 2018 Mar 21.

Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.

During the last years, proteomic studies have revealed several interesting findings in experimental sepsis models and septic patients. However, most studies investigated protein alterations only in single organs or in whole blood. To identify possible sepsis biomarkers and to evaluate the relationship between protein alteration in sepsis affected organs and blood, proteomics data from the heart, brain, liver, kidney, and serum were analysed. Read More

Radiother Oncol 2018 08 30;128(2):343-348. Epub 2018 Jun 30.

Erasmus MC Cancer Institute, Erasmus University Rotterdam, Radiation Oncology, Rotterdam, The Netherlands.

Background And Purpose: Reported plan quality improvements with autoplanning of radiotherapy of the prostate and seminal vesicles are poor. A system for automated multi-criterial planning has been validated for this treatment in a large international multi-center study. The system is configured with training plans using a mechanism that strives for quality improvements relative to those plans. Read More

Cell Tissue Res 2018 Nov 28;374(2):243-249. Epub 2018 Jun 28.

Department of Physiology, University of Szeged, Szeged, Hungary.

Recent studies demonstrated the expression of the insulin receptor (InsR) and its functional interaction with the transient receptor potential vanilloid type 1 receptor (TRPV1) in primary sensory neurons (PSNs). The present study was undertaken to reveal the target-specific expression of the InsR and its co-localization with the TRPV1 in rat PSNs. We assessed the localization of the InsR and its co-localization with the TRPV1 in PSNs retrogradely labelled with biotin-conjugated wheat germ agglutinin injected into the dorsal hind paw skin, the gastrocnemius muscle, the pancreas and the urinary bladder wall. Read More

Eur J Histochem 2018 Apr 3;62(2):2870. Epub 2018 Apr 3.

"Institute of Experimental Medicine".

Amyloidosis is a group of diseases that occurs when amyloid proteins are deposited in tissues and organs. The traditional way of identifying amyloid in tissue sections is staining with Congo red. However, this method has a number of limitations including background staining (background fluorescence), low fluorescence intensity and false-positive staining. Read More