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Future Microbiol 2022 Jun 15. Epub 2022 Jun 15.

Centre for Biotechnology, Maharshi Dayanand University, Rohtak, 124001, India.

Diagnosis of urogenital tuberculosis (UGTB) is difficult and there is an immediate need to develop a reliable diagnostic test. A real-time immuno-PCR (RT-I-PCR) was developed to identify a cocktail of MPT-64 + ESAT-6 in both male/female UGTB patients comprising five confirmed cases, 40 clinically suspected cases and 37 non-TB controls, from whom mid-stream urine specimens were collected, while endometrial biopsies of female patients were obtained on day 1 of their menstrual cycle. Results obtained by RT-I-PCR were compared with I-PCR/ELISA and GeneXpert. Read More

Med J Malaysia 2022 05;77(3):384-387

Hospital Kuala Lumpur, Malaysia.

Renal involvement in sarcoidosis is very uncommon and often diagnosed through renal biopsy. It is a chronic and multisystem disease with unknown aetiology and can affect all organs of the body with strong predilection to the lungs. Although glucocorticoids are effective in the treatment of sarcoidosis, the mainstay of management includes supportive hydration and prevention of nephrotoxins. Read More

Dis Aquat Organ 2022 May 24;149:59-70. Epub 2022 May 24.

The Marine Mammal Center, Sausalito, California 94965, USA.

Two emaciated male northern elephant seal (NES) Mirounga angustirostris pups were admitted to The Marine Mammal Center (Sausalito, California, USA) and treated for malnutrition. Complete blood counts showed a progressive moderate to marked leukocytosis characterized by a predominance of large monomorphic mononuclear cells of probable lymphoid origin, frequently with flower-shaped nuclei. Both seals were euthanized due to suspected lymphoid neoplasia. Read More

J Med Case Rep 2022 May 23;16(1):220. Epub 2022 May 23.

Department of Medicine, Einstein Medical Center Philadelphia, Philadelphia, PA, USA.

Background: Bilateral ureteropelvic junction obstruction is a common cause of secondary hypertension in the pediatric population, often due to congenital malformation. On the other hand, it is less frequently encountered in the adult population and is usually due to an acquired condition, most commonly by a bilaterally obstructing nephrolithiasis causing hydronephrosis and subsequent hypertension. The aim of this study was to investigate and highlight the underlying mechanisms by which acute bilateral ureteropelvic junction obstruction causes hypertensive crisis and why early detection and prompt treatment are necessary to mitigate the effects of elevated blood pressure on target organs. Read More

Taiwan J Obstet Gynecol 2022 May;61(3):528-531

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.

Objective: We present prenatal diagnosis of high-level mosaicism for 45,X in 45,X/46,X,idic(Y)(q11.2) at amniocentesis in a pregnancy with a favorable outcome and postnatal progressive decrease of the 45,X cell line.

Case Report: A 36-year-old, gravida 4, para 3, woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Read More

Toxicol Lett 2022 Jun 17;363:36-44. Epub 2022 May 17.

Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, İzmir, Turkey. Electronic address:

Mitochondria appeared to be a major target for paracetamol (PAR)-induced hepatotoxicity. Studies suggested that microsomal CYPs catalyse bioactivation of PAR to N-acetyl-p-benzoquinone imine (NAPQI), which alkylates mitochondrial proteins, and causes transmission of death signal from mitochondria to nucleus. We hypothesised that local formation of NAPQI within mitochondria seems more likely compared to the translocation of NAPQI. Read More

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2022 Apr;40(4):255-259

Department of Occupational Disease and Poisoning Medicine, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China.

To explore the expulsion effect of sodium dimercaptopropanesulfonate (DMPS) on mercury in different organs of mercury poisoning and the therapeutic effect of glutathione (GSH) combined with antioxidant therapy on mercury poisoning. In February 2019, 50 SPF male SD rats were randomly divided into 5 groups, 10 rats in each group: A (saline negative control group) , B (HgCL2 positive control group) , treatment group (C: intramuscular injection of DMPS 15 mg/kg treatment, D: intramuscular injection of DMPS30 mg/kg treatment, E: intramuscular injection of DMPS 15 mg/kg and intraperitoneal injection of GSH200 mg/kg treatment) . Rats in group B, C, D and E were subcutaneously injected with mercury chloride solution (1 mg/kg) to establish a rat model of subacute mercury poisoning kidney injury. Read More

PLoS One 2022 11;17(5):e0263605. Epub 2022 May 11.

Department of Pathobiology, Faulty of Veterinary and Animal Sciences, University of Poonch Rawalakot (UPR), Azad Jammu & Kashmir, Pakistan.

Poisonous plants cause tremendous economic losses to the livestock industry. These economic losses are deterioration in their health, decreased productivity, deformed offspring, and reduced longevity. The current study is the first comprehensive report on poisonous plants of Azad Jammu and Kashmir which systematically documents the phytotoxicological effect and mode of action in livestock. Read More

PLoS One 2022 10;17(5):e0268183. Epub 2022 May 10.

Division of Nephrology, Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa.

Background: Living kidney donation has been advocated as a means to ameliorate the chronic shortage of organs for transplantation. Significant rates of comorbidity and familial risk for kidney disease may limit this approach in the local context; there is currently limited data describing living donation in Africa.

Methods: We assessed reasons for non-donation and outcomes following donation in a cohort of 1208 ethnically diverse potential living donors evaluated over a 32-year period at a single transplant centre in South Africa. Read More

Comput Biol Med 2022 Jul 26;146:105555. Epub 2022 Apr 26.

Vanderbilt University, Department of Computer Science, Nashville, USA; Vanderbilt University Medical Center, Department of Radiology, Nashville, USA.

The construction of three-dimensional multi-modal tissue maps provides an opportunity to spur interdisciplinary innovations across temporal and spatial scales through information integration. While the preponderance of effort is allocated to the cellular level and explore the changes in cell interactions and organizations, contextualizing findings within organs and systems is essential to visualize and interpret higher resolution linkage across scales. There is a substantial normal variation of kidney morphometry and appearance across body size, sex, and imaging protocols in abdominal computed tomography (CT). Read More

Kidney Int 2022 Jul 2;102(1):196-206. Epub 2022 May 2.

Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China; Renal Pathological Center, Institute of Nephrology, Peking University, Beijing, China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.

High-altitude polycythemia (HAPC) is a clinical syndrome that occurs in native inhabitants or long-term residents living at altitude. The kidney is one of the most affected organs. However, the clinical and kidney histopathological profiles of HAPC-related kidney disease have rarely been reported. Read More

Nucl Med Commun 2022 Jul 4;43(7):847-854. Epub 2022 May 4.

The PET/CT Center, Department of Nuclear Medicine, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China.

Objective: To systematically investigate the physiological distribution and benign lesion incidental uptake of Al18F-NOTA-FAPI-04 (18F-FAPI) in cancer patients to establish the normal uptake range in relevant organs and lesions.

Methods: Twenty patients who underwent 18F-FAPI PET/CT imaging were retrospectively assessed. Organ and benign lesion tracer uptake was quantified based on standardized uptake values (SUVmax and SUVmean). Read More

Urologiia 2022 May(2):90-94

Rostov State Medical University, Rostov-on-Don, Russia.

Chronic recurrent cystitis (CRC) is one of the most common diseases of the lower urinary tract in the female population. Difficulties in diagnosis and treatment, despite the observance of modern clinical recommendations for CRC, are due to the versatility and polyetiology of the pathogenesis of the disease. The most difficult and discussed section of this problem is the diagnosis and treatment of CRC of papillomavirus (PV) etiology. Read More

J Med Case Rep 2022 Apr 28;16(1):173. Epub 2022 Apr 28.

Ist. Patologia Ostetrica e Ginecologica, Department of General Surgery and Medical Surgical Specialities, University of Catania, Via Santa Sofia 78, 95100, Catania, Italy.

Introduction And Importance: The most common complication of pelvic organ prolapse is stress urinary incontinence, whereas hydronephrosis or stasis ulcers are quite rare and typical of severe stages. The best treatment for this unusual presentation is still controversial. Here we present our approach. Read More

Comput Math Methods Med 2022 12;2022:2890535. Epub 2022 Apr 12.

Ophthalmology, Zhuanglang County People's Hospital, Pingliang, 744600 Gansu, China.

As one of the most important organs of human beings, the eyes can receive external visual information and play an important role in perception. Therefore, the method of maintaining eye health is a problem that people pay attention to. Omental disease is one of the most serious microvascular complications in diabetic patients, and it is also the main cause of blindness in patients. Read More

Mol Biol Rep 2022 May 20;49(5):4135-4140. Epub 2022 Apr 20.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

Background: Autosomal recessive cutis laxa (ARCL) is a heterogeneous disorder with three primary forms (ARCL 1, ARCL 2 and ARCL 3). Latent transforming growth factor beta binding protein 4 (LTBP4) anomalies cause ARCL1C and are connected to different problems in the skin and other organs. Herein, we present a seven month old Iranian boy with a clinical manifestation of ARCL1 with literature review of previous cases with attributes of ARCL1C. Read More

Radiologe 2022 May 20;62(5):439-450. Epub 2022 Apr 20.

Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Brandenburg an der Havel - Medizinische Hochschule Brandenburg Theodor Fontane, Hochstraße 29, 14770, Brandenburg an der Havel, Deutschland.

For masses of the spleen, which are mostly benign, accessory spleens, cysts and hemangiomas should be radiologically described; however, if confirmed further follow-up control is unnecessary. In the case of disseminated small masses, chronic inflammation and granulomatous diseases, such as tuberculosis and sarcoidosis should be considered in the differential diagnostics. Solid masses in the kidneys should always be further clarified, with the exception of a fat-rich angiomyolipoma. Read More

Neurourol Urodyn 2022 06 14;41(5):1074-1081. Epub 2022 Apr 14.

Department of Urology, Hyogo College of Medicine, Hyogo, Japan.

Purpose: Few studies have examined the effects of body position on urination efficiency morphologically. We aimed to dissect out the anatomical changes of pelvic organs during urination in the upright and supine positions by a real-time magnetic resonance imaging (rtMRI) system.

Methods: Thirteen healthy male volunteers aged 26-60 years were included in the study. Read More

Georgian Med News 2022 Mar(324):38-45

I. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); LLC «Set Semeinyh Medicinskih Centrov», Moscow; N. Pirogov Russian National Research Medical University of the Russian, Moscow, Russia.

Objective - to evaluate the results of surgical correction of anterior apical prolapse of the pelvic organs with a combined technique monolateral CYRENE posterior (using monofilament polypropylene tape CYRENE) in combination with anterior colporrhaphy. A prospective cohort study included 240 patients with urogenital prolapse. The subjects were followed up for three months, and the anatomical outcome according to the POP-Q System classification, intra- and postoperative complications, absence or presence of relapse, quality of life and sex life were assessed. Read More

Abdom Radiol (NY) 2022 Apr 12. Epub 2022 Apr 12.

Department of Radiology, University of Cincinnati, Cincinnati, USA.

Male genitourinary neuroendocrine neoplasms (GU-NENs) are rare, without any definite imaging characteristics. The WHO classified neuroendocrine neoplasms in the 2016 classification of the tumors of the urinary tract and genital organs along with other GU tumors; however, no pathologic grading system is available as published for gastroenteropancreatic neuroendocrine neoplasms. Often a multimodality approach using cross-sectional imaging techniques, such as molecular imaging and histopathology are implemented to arrive at the diagnosis. Read More

Arh Hig Rada Toksikol 2022 Apr 7;73(1):43-47. Epub 2022 Apr 7.

Institute for Medical Research and Occupational Health, Toxicology Unit, Zagreb, Croatia.

Ochratoxin A (OTA) and citrinin (CTN) are nephrotoxic mycotoxins often found together in grain. The aim of this study was to measure their accumulation in the kidney and liver of adult male Wistar rats, see how it would be affected by combined treatment, and to determine if resveratrol (RSV) would decrease their levels in these organs. The rats received 125 or 250 mg/kg bw of OTA by gavage every day for 21 days and/or 20 mg/kg bw of CTN a day for two days. Read More

Arh Hig Rada Toksikol 2022 Apr 7;73(1):48-61. Epub 2022 Apr 7.

Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Ferritin is the main intracellular storage of iron. Animal studies show that female liver and kidney express more ferritin and accumulate more iron than male. However, no study so far has investigated sex and age differences in light (FtL) and heavy (FtH) ferritin chain expression. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221089495

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Renal trauma occurring in patients with unilateral renal cystic disease (URCD) is extremely rare. Unilateral renal cystic disease is benign, nonprogressive, nonfamilial, nonencapsulated, and unrelated to cysts in other organs. It should be differentiated from autosomal dominant polycystic kidney disease (ADPKD) parenthesis, multicystic dysplastic kidney disease, multiple renal simple cysts, and cystic renal neoplasms. Read More

Biomed Res Int 2022 22;2022:3176455. Epub 2022 Mar 22.

Faculty of Medicine, Department of Anesthesiology and Reanimation, Gazi University, Ankara, Turkey.

Introduction: Testicular torsion is a surgical emergency that results in testicular ischemia as a result of rotation of the spermatic cord around itself. Oxidative damage occurs in the testis and distant organs with the overproduction of free radicals and overexpression of proinflammatory cytokines by reperfusion after surgery. In this study, we aimed to investigate the effects of cerium oxide (CeO), an antioxidant nanoparticle, on lung and kidney tissues in testicular torsion/detorsion (T/D) in rats. Read More

Infect Immun 2022 04 31;90(4):e0053221. Epub 2022 Mar 31.

Comparative Medicine Program, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.

Urinary tract infection (UTI) is one of the most prevalent bacterial infections, particularly in women, children, and the elderly. Uropathogenic Escherichia coli (UPEC) is the predominant etiological agent of UTI. Uropathogens are directly instilled in the urinary bladder, bypassing the lower urogenital tract, in the widely used murine model of UTI. Read More

Arch Razi Inst 2021 11 30;76(5):1501-1508. Epub 2021 Nov 30.

Ministry of Sciences and Technology, Environment and Water Directorate, Baghdad, Iraq.

Heavy metals have a wide application in the industrial world, affecting the health and longevity of living organisms. The current study assessed the possible effects of Cadmium (Cd) and Zinc (Zn) on the liver and kidney. Therefore, 150 male and female white mice C57BL were treated in three different groups with 0. Read More

Ann Ital Chir 2022 ;92:102-107

Background: The injury mechanism of a pelvic fracture is primarily high-energy injury, and it is easily combined with injuries to other tissues and organs. This study aimed to investigate the clinical effectiveness of early diagnosis and treatment of pelvic fractures and associated injuries in children.

Methods: The diagnosis and treatment of 60 children with pelvic fractures and associated injuries who were admitted to our hospital from January 2005 to December 2016 were retrospectively analyzed. Read More

Am J Case Rep 2022 Mar 25;23:e935141. Epub 2022 Mar 25.

Department of Pathology, Military Institute of Medicine, Warsaw, Poland.

BACKGROUND Extramedullary hematopoiesis in organs outside the bone marrow most commonly occurs in the liver and spleen. This report is of a case of multifocal extramedullary and non-hepatosplenic extramedullary hematopoiesis a 43-year-old man with a history of congenital Eisenmenger syndrome. CASE REPORT We present the case of a 43-year-old patient with complex heart disease and full-blown Eisenmenger syndrome associated with ventricular septal defect, bicuspid right ventricle, and pulmonary hypertension. Read More

Zhonghua Yi Xue Za Zhi 2022 Mar;102(12):870-876

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

To analyze the clinical features and spinal lesions related to micturitionin of chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS) patients. Patients with CP/CPPS were enrolled to this study at the outpatient department of Tongji Hospital between January and June 2019. The data of clinical features was collected and analyzed, including lower urinary tract symptoms(LUTS), bowel syndrome and pain over different parts of body, as well as lower urinary tract dysfunction, spinal lesions and pelvic organ morphological changes demonstrated by MRI. Read More

Evid Based Complement Alternat Med 2022 9;2022:1980622. Epub 2022 Mar 9.

Laboratory of Animal Physiology, Department of Animal Biology, Faculty of Science, University of Yaoundé I, PO Box 812, Yaoundé, Cameroon.

High blood pressure (HBP) is currently one of the main risk factors for cardiovascular and kidney diseases. Nowadays, populations make extensive use of alternative medicine for their health problems. (. Read More