285,090 results match your criteria Male Reproductive Organs

High-level mosaicism for 45,X in 45,X/46, XY at amniocentesis in a pregnancy with a favorable fetal outcome and cytogenetic discrepancy in various tissues.

Taiwan J Obstet Gynecol 2022 Jul;61(4):695-699

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.

Objective: We present prenatal diagnosis of high-level mosaicism for 45,X by amniocentesis in a pregnancy with a favorable fetal outcome.

Case Report: A 35-year-old, gravida 2, para 1, woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Amniocentesis revealed a karyotype of 45,X[13]/46,XY[11]. Read More

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Physiological Characterization of the Transporter-Mediated Uptake of the Reversible Male Contraceptive H2-Gamendazole Across the Blood-Testis Barrier.

J Pharmacol Exp Ther 2022 Jul 2. Epub 2022 Jul 2.

Pharmacology & Toxicology, University of Arizona, United States

The blood-testis barrier (BTB) is formed by a tight network of Sertoli cells (SCs) to limit the movement of reproductive toxicants from the blood into the male genital tract. Transporters expressed at the basal membranes of SCs also influence the disposition of drugs across the BTB. The reversible, non-hormonal contraceptive, H2-gamendazole (H2-GMZ), is an indazole carboxylic acid analog that accumulates over 10 times more in the testes compared to other organs. Read More

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Effect of dihydrotestosterone on melatonin secretion and the expression of melatonin receptors and apoptosis-related factors in sheep epididymides.

Reprod Domest Anim 2022 Jul 1. Epub 2022 Jul 1.

College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.

Melatonin (MEL) is involved in homeostasis of the epididymis lumen environment. Dihydrotestosterone (DHT) partakes in the development of gonads and organs in male animals. However, whether MEL secretion, the expression of its receptors, MT1 and MT2, and sheep epididymal epithelial cell apoptosis is regulated by DHT remains unclear. Read More

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Dimethyl Sulfoxide Attenuates Radiation-Induced Testicular Injury through Facilitating DNA Double-Strand Break Repair.

Oxid Med Cell Longev 2022 20;2022:9137812. Epub 2022 Jun 20.

Department of Endocrinology, The PLA Rocket Force Characteristic Medical Center, Beijing, China.

The testis is susceptible to ionizing radiation, and male infertility and sexual dysfunction are prevalent problems after whole-body or local radiation exposure. Currently, there is no approved agent for the prevention or treatment of radiation-induced testicular injury. Herein, we investigated the radioprotective effect of dimethyl sulfoxide (DMSO), an organosulfur compound that acts as a free radical scavenger, on testicular injury. Read More

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FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation.

Front Cell Dev Biol 2022 13;10:914053. Epub 2022 Jun 13.

Laboratory of Cancer Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czechia.

The ubiquitin ligase SCF controls centromeric chromatin by promoting the degradation of the ZXDB protein. To determine the importance of this pathway during development, -deficient mice were generated. The loss of FBXO38 resulted in growth retardation affecting several organs, including the male reproductive system. Read More

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Pathological predictors of F-DCFPyL prostate-specific membrane antigen-positive recurrence after radical prostatectomy.

BJU Int 2022 Jun;130 Suppl 1:28-36

Department of Medical Imaging, St. Vincent's Hospital, Melbourne, Vic., Australia.

Objectives: To assess the correlation of pathological radical prostatectomy (RP) specimen features and prostate-specific antigen (PSA) characteristics to imaging findings on subsequent F-DCFPyL positron emission tomography/computed tomography (PET/CT) in patients with biochemical failure (BF).

Patients And Methods: Retrospective analysis of combined F-DCFPyL PET/CT database of patients from centres in Australia and New Zealand was performed. A total of 205 patients presenting with BF after RP were included in this study. Read More

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Association of pre-pregnancy body mass index and gestational weight gain with neonatal anogenital distance in a Chinese birth cohort.

Reprod Health 2022 Jun 29;19(1):152. Epub 2022 Jun 29.

NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, #779 Lao Hu Min Road, Shanghai, 200032, China.

Background: This study aimed to investigate the associations of pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with anogenital distance (AGD) among newborns.

Methods: The study included 556 mother-newborn pairs from the Jiashan birth cohort. AGD was measured as AGD (from the center of the anus to the anterior base of the penis, where the penile tissue meets the pubic bone) and AGD (from the center of the anus to the posterior base of the scrotum, where the skin changes from rugate to smooth) in males and AGD (from the center of the anus to the clitoris) and AGD (from the center of the anus to the posterior convergence of the fourchette) in females. Read More

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TCFL5 deficiency impairs the pachytene to diplotene transition during spermatogenesis in the mouse.

Sci Rep 2022 Jun 29;12(1):10956. Epub 2022 Jun 29.

Centro de Biología Molecular Severo Ochoa, Nicolás Cabrera 1, Cantoblanco, 28049, Madrid, Spain.

Spermatogenesis is a complex, multistep process during which spermatogonia give rise to spermatozoa. Transcription Factor Like 5 (TCFL5) is a transcription factor that has been described expressed during spermatogenesis. In order to decipher the role of TCFL5 during in vivo spermatogenesis, we generated two mouse models. Read More

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Floral biology and reproductive system of physic nut (Jatropha curcas L., Euphorbiaceae) in 'Recôncavo da Bahia', Brazil.

An Acad Bras Cienc 2022 27;94(3):e20201814. Epub 2022 Jun 27.

Universidade Federal da Bahia, Instituto de Biologia, Laboratório de Bionomia, Biogeografia e Sistemática de Insetos, Rua Barão de Jeremoabo, 668, Ondina, 40170-290 Salvador, BA, Brazil.

Understanding the floral and reproductive biology of botanical species is crucial for the development of strategies in plant breeding systems. Jatropha curcas L. is a promising species for the manufacture of biofuels, being previously studied mainly in genetic improvement to develop characteristics suitable to biofuels. Read More

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Characterization of reproductive proteins in the Mexican fruit fly points towards the evolution of novel functions.

Proc Biol Sci 2022 Jun 29;289(1977):20212806. Epub 2022 Jun 29.

Department of Biology, College of Wooster, 931 College Mall, Wooster, OH 44691, USA.

Seminal fluid proteins (Sfps) modify female phenotypes and have wide-ranging evolutionary implications on fitness in many insects. However, in the Mexican fruit fly, , a highly destructive agricultural pest, the functions of Sfps are still largely unknown. To gain insights into female phenotypes regulated by Sfps, we used nano-liquid chromatography mass spectrometry to conduct a proteomic analysis of the soluble proteins from reproductive organs of . Read More

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Combined robotic and subinguinal microsurgical vasovasostomy for vasal obstruction after inguinal hernia repair.

BMJ Case Rep 2022 Jun 28;15(6). Epub 2022 Jun 28.

Department of Urology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Obstruction of the vas deferens may occur after inguinal hernia repair with mesh and lead to infertility. In cases where natural conception is desired and after obtaining test results that suggest the presence of spermatogenesis, surgical reconstruction can be attempted but may be difficult. Several approaches have been reported, including the laparoscopic mobilisation of the pelvic vas deferens, as well as mobilisation and passage of the scrotal vas deferens intra-abdominally for robot-assisted vasovasostomy. Read More

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Male reproductive toxicity of inorganic nanoparticles in rodent models: A systematic review.

Chem Biol Interact 2022 Jun 25:110023. Epub 2022 Jun 25.

Laboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

The use of nanoscale materials for different biomedical applications has grown a lot in the last years and raised several concerns about toxic effects on human health. Several studies have shown that different types of NPs may exert toxic effects on organs such as the brain, the liver and the kidney. However, The toxicological effects of inorganic NPs on reproductive organs only recently has attracted attention. Read More

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Sperm Limitation Produces Male Biased Offspring Sex Ratios in the Wasp, Nasonia vitripennis (Hymenoptera: Pteromalidae).

J Insect Sci 2022 May;22(3)

Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA.

Haplo-diploid sex determination in the parasitoid wasp, Nasonia vitripennis (Walker), allows females to adjust their brood sex ratios. Females influence whether ova are fertilized, producing diploid females, or remain unfertilized, producing haploid males. Females appear to adjust their brood sex ratios to minimize 'local mate competition,' i. Read More

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Beneficial effects of Salvia officinalis essential oil on vanadium-induced testicular injury, DNA damage and histological alterations in Wistar rats.

Biometals 2022 Jun 28. Epub 2022 Jun 28.

Laboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, Sfax, Tunisia.

Vanadium has been shown to catalyze the generation of reactive oxygen species. Since free radical production and lipid peroxidation are potentially important mediators in testicular physiology and pathophysiology, the present study was conducted to elucidate vanadium-induced oxidative damage in rat testis and the ameliorative role of Salvia officinalis essential oil (SEO) against the adverse effects of this heavy metal. Adult male Wistar rats were treated daily during 10 days either with ammonium metavanadate (5 mg/kg bw, intraperitoneally), SEO (15 mg/kg bw, orally) or their combination. Read More

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Genital Gender Affirming Surgery.

Am Surg 2022 Jun 28:31348221109479. Epub 2022 Jun 28.

Department of Urology, 2331UNC School of Medicine, Chapel Hill, NC, USA.

Genital gender affirming surgery is an effective treatment for gender dysphoria in transgender individuals. Optimization of medical and mental health conditions, including coordination with a patient's entire care team, is essential. Feminizing procedures include vaginoplasty (creation of female genitalia with a vaginal canal) and vulvoplasty (creation of female genitalia with a short or absent vaginal canal). Read More

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Investigation of the Disparities in Ultrasound Imaging Features of miR-323, miR-409-3p, and VEGF Expression Scales in Different Clinicopathological Features of Prostate Carcinoma and Their Correlation with Prognosis.

Biomed Res Int 2022 18;2022:5053204. Epub 2022 Jun 18.

Emergency Ultrasound Department of the First Hospital of Shanxi Medical University, Taiyuan 030001, China.

Prostate carcinoma (PC) is a disease of the male genitourinary system and a relatively common malignant tumor. In order to investigate the disparities in the expression of microRNA-323 (miR-323), microRNA-409-3p (miR-409-3p), and vascular endothelial growth factor (VEGF) in prostate carcinoma with different clinicopathological features and analyze their correlation with prognosis. Thirty-two sufferers with prostate carcinoma and forty-three sufferers with benign prostatic hyperplasia are included. Read More

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A Modified Vessel-sparing Microsurgical Vasoepididymostomy.

J Vis Exp 2022 Jun 8(184). Epub 2022 Jun 8.

Assisted Reproduction Center, Northwest Women's and Children's Hospital.

Microsurgical vasoepididymostomy (MVE) is the main surgical treatment for epididymal obstruction. The vasal vessels are ligated during MVE. However, preserving the vasal vessels during MVE might better simulate the normal physiological structure and be meaningful for patients who have undergone varicocelectomy. Read More

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Wiad Lek 2022 ;75(5 pt 2):1313-1316


Objective: The aim: The study carried out to determine the effect of the Calcium Oxide Nano Particles on the male rats. In this study were used calcium oxide nano powder to enhancing apoptosis in germ cells and disrupting hormonal regulation of reproductive processes in the adult male rats.

Patients And Methods: Materials and methods: The experiment using nine male rats, were distributed into three groups. Read More

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Segmented linear correlations between bone scan index and prostate cancer biomarkers, alkaline phosphatase, and prostate specific antigen in patients with a Gleason score ≥7.

Medicine (Baltimore) 2022 Jun 24;101(25):e29515. Epub 2022 Jun 24.

Department of Nuclear Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Abstract: Technetium-99m methyl diphosphonate bone scintigraphy is relatively easily accessible for detecting bone metastases in prostate cancer patients. However, it is subjective and can be challenging to compare images taken at different time points. The bone scan index (BSI) is a more objective evaluation and allows for better comparison of images. Read More

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Sertoli Cell Immune Regulation: A Double-Edged Sword.

Front Immunol 2022 9;13:913502. Epub 2022 Jun 9.

Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, United States.

The testis must create and maintain an immune privileged environment to protect maturing germ cells from autoimmune destruction. The establishment of this protective environment is due, at least in part, to Sertoli cells. Sertoli cells line the seminiferous tubules and form the blood-testis barrier (BTB), a barrier between advanced germ cells and the immune system. Read More

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Adipose Mesenchymal Stromal Cell-Derived Exosomes Prevent Testicular Torsion Injury Activating PI3K/AKT and MAPK/ERK1/2 Pathways.

Oxid Med Cell Longev 2022 16;2022:8065771. Epub 2022 Jun 16.

Department of Pediatric Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Nangang District, Harbin 150001, China.

Adipose mesenchymal stromal cell-derived exosomes (ADSC-Exos) have shown great potential in the treatment of oxidative stress induced by ischemia-reperfusion injury. However, alleviation of testicular torsion injury by ADSC-Exos has not been reported. Therefore, we investigated the protective effect of ADSC-Exos against testicular torsion-detorsion injury. Read More

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Organotypic Rat Testicular Organoids for the Study of Testicular Maturation and Toxicology.

Front Endocrinol (Lausanne) 2022 9;13:892342. Epub 2022 Jun 9.

Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada.

An system to study testicular maturation in rats, an important model organism for reproductive toxicity, could serve as a platform for high-throughput drug and toxicity screening in a tissue specific context. maturation of somatic cells and spermatogonia in organ culture systems has been reported. However, this has been a challenge for organoids derived from dissociated testicular cells. Read More

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Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications.

Front Endocrinol (Lausanne) 2022 10;13:897062. Epub 2022 Jun 10.

Department of Endocrine Neoplasia and Hormonal Disorders, MD Anderson Cancer Center, Houston, TX, United States.

Male germ cell development depends on multiple biological events that combine epigenetic reprogramming, cell cycle regulation, and cell migration in a spatio-temporal manner. Sertoli cells are a crucial component of the spermatogonial stem cell niche and provide essential growth factors and chemokines to developing germ cells. This review focuses mainly on the activation of master regulators of the niche in Sertoli cells and their targets, as well as on novel molecular mechanisms underlying the regulation of growth and differentiation factors such as GDNF and retinoic acid by NOTCH signaling and other pathways. Read More

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[Anatomical observation and clinical significance of the prostatic part of neurovascular bundle in total mesorectal excision].

Zhonghua Wei Chang Wai Ke Za Zhi 2022 Jun;25(6):505-512

Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, China.

To observe the anatomical architecture of the prostatic part of the neurovascular bundle (NVB) in total mesorectal excision (TME). A descriptive cohort study and an anatomical observation study were carried out. A total of 38 male patients with rectal cancer who underwent TME in the Department of Colorectal Surgery at the affiliated Union hospital of Fujian Medical University between November 2013 and March 2015 were included. Read More

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Changes in prostate cancer survival among insured patients in relation to USPSTF screening recommendations.

BMC Urol 2022 Jun 25;22(1):91. Epub 2022 Jun 25.

Department of Urology, Yale School of Medicine, 789 Howard Avenue, Fitkin 307, New Haven, CT, 06520, USA.

Background: To investigate the effects of the U.S. Preventive Services Task Force's (USPSTF) 2012 recommendation against prostate-specific antigen (PSA)-based screening for prostate cancer on survival disparities based on insurance status. Read More

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Unraveling mitochondrial piRNAs in mouse embryonic gonadal cells.

Sci Rep 2022 Jun 24;12(1):10730. Epub 2022 Jun 24.

Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas C.I.B. (CSIC), Ramiro de Maeztu 9, 28040, Madrid, Spain.

Although mitochondria are widely studied organelles, the recent interest in the role of mitochondrial small noncoding RNAs (sncRNAs), miRNAs, and more recently, piRNAs, is providing new functional perspectives in germ cell development and differentiation. piRNAs (PIWI-interacting RNAs) are single-stranded sncRNAs of mostly about 20-35 nucleotides, generated from the processing of pre-piRNAs. We leverage next-generation sequencing data obtained from mouse primordial germ cells and somatic cells purified from early-differentiating embryonic ovaries and testis from 11. Read More

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Basal cell carcinoma of the prostate: a case report responding to the FGFR inhibitor pemigatinib and literature review.

Curr Opin Urol 2022 Jul;32(4):358-363

Department of Pathology, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: Due to the limited number of cases, there are no guidelines for basal cell carcinoma (BCC) of the prostate. This review combines an unpublished case report of a 55-year-old patient with BCC with an assessment of the latest literature.

Recent Findings: BCC of the prostate has previously been described in only approximately 140 cases. Read More

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The Penis, the Vagina and HIV Risk: Key Differences (Aside from the Obvious).

Viruses 2022 May 27;14(6). Epub 2022 May 27.

Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.

Globally, most Human Immunodeficiency Virus type 1 (HIV) transmission occurs through vaginal-penile sex (heterosexual transmission). The local immune environment at the site of HIV exposure is an important determinant of whether exposure during sex will lead to productive infection, and the vaginal and penile immune milieus are each critically shaped by the local microbiome. However, there are key differences in the microbial drivers of inflammation and immune quiescence at these tissue sites. Read More

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Lutein Can Alleviate Oxidative Stress, Inflammation, and Apoptosis Induced by Excessive Alcohol to Ameliorate Reproductive Damage in Male Rats.

Nutrients 2022 Jun 9;14(12). Epub 2022 Jun 9.

Institute of Nutrition and Health, School of Public Health, Qingdao University, Qingdao 266021, China.

Chronic excessive alcohol intake may lead to male reproductive damage. Lutein is a carotenoid compound with antioxidant activity. The purpose of this study was to observe the effect of lutein supplementation on male reproductive damage caused by excessive alcohol intake. Read More

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TRPM8 as an Anti-Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination.

Int J Mol Sci 2022 Jun 15;23(12). Epub 2022 Jun 15.

CNRS, INSERM, CHU Lille, Centre Oscar Lambret, UMR 9020-UMR 1277-Canther-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University Lille, 59000 Villeneuve d'Ascq, France.

In the fight against prostate cancer (PCa), TRPM8 is one of the most promising clinical targets. Indeed, several studies have highlighted that TRPM8 involvement is key in PCa progression because of its impact on cell proliferation, viability, and migration. However, data from the literature are somewhat contradictory regarding the precise role of TRPM8 in prostatic carcinogenesis and are mostly based on in vitro studies. Read More

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