266,208 results match your criteria Male Reproductive Organs


The coevolution of male and female genitalia in a mammal: a quantitative genetic insight.

Evolution 2020 Jun 3. Epub 2020 Jun 3.

Centre for Evolutionary Biology, School of Biological Sciences (M092), The University of Western Australia, Crawley, 6009, Australia.

Male genitalia are among the most phenotypically diverse morphological traits, and sexual selection is widely accepted as being responsible for their evolutionary divergence. Studies of house mice suggest that the shape of the baculum (penis bone) affects male reproductive fitness and experimentally imposed postmating sexual selection has been shown to drive divergence in baculum shape across generations. Much less is known of the morphology of female genitalia and its coevolution with male genitalia. Read More

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http://dx.doi.org/10.1111/evo.14031DOI Listing

Identification and characterization of male reproduction-related genes in pig (Sus scrofa) using transcriptome analysis.

BMC Genomics 2020 Jun 1;21(1):381. Epub 2020 Jun 1.

Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, PR China.

Background: The systematic interrogation of reproduction-related genes was key to gain a comprehensive understanding of the molecular mechanisms underlying male reproductive traits in mammals. Here, based on the data collected from the NCBI SRA database, this study first revealed the genes involved in porcine male reproduction as well their uncharacterized transcriptional characteristics.

Results: Results showed that the transcription of porcine genome was more widespread in testis than in other organs (the same for other mammals) and that testis had more tissue-specific genes (1210) than other organs. Read More

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http://dx.doi.org/10.1186/s12864-020-06790-wDOI Listing

Mating with immunised male mice affects the phenotype of adult progeny.

Reproduction 2020 Jul;160(1):117-127

Federal Research Center Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.

The life-history theory suggests that parental experience of the environment is passed to offspring, which allows them to adapt to prevailing conditions. This idea is supported from the mother's side, but to a much less extent from the father's side. Here, we investigated the effect of immunising fathers on pre- and neonatal development and on immune and neuroendocrine phenotypes of their offspring in C57BL/6J mice. Read More

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http://dx.doi.org/10.1530/REP-19-0360DOI Listing

Luteolin protects against testicular injury induced by lead acetate by activating the Nrf2/HO-1 pathway.

IUBMB Life 2020 Jun 1. Epub 2020 Jun 1.

Biology Department, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

Lead (Pb) is a toxic heavy metal that is harmful to humans, especially male reproductive organs. Luteolin (LUT) is a naturally occurring flavonoid with numerous biological activities. Our aim was to investigate the possible reproprotective effect of LUT against testicular deficits induced by Pb intoxication. Read More

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http://dx.doi.org/10.1002/iub.2311DOI Listing
June 2020
3.143 Impact Factor

A Diagnostic Loop-Mediated Isothermal Amplification Method to Distinguish Helicoverpa armigera (Lepidoptera: Noctuidae) From Other Related Species in the New World.

J Insect Sci 2020 May;20(3)

Laboratory of Applied Entomology, Graduate School of Horticulture, Chiba University, Matsudo, Chiba, Japan.

Helicoverpa armigera (Hübner) is a notorious agricultural pest native to the Old World. Recently, its invasion into South and Central America has become a serious problem in the New World. The rapid detection of invasive pests is essential to eradicate them and prevent establishment. Read More

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http://dx.doi.org/10.1093/jisesa/ieaa046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251530PMC

[Transmission electron microscopic observation on gonad of offspring bred in Weishan Lake areas].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Oct;32(2):195-197

Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Acadenmy of Medical Sciences, Jining 272033, China.

Objective: To observe the morphological changes in the testes and ovaries of adult 12th-generation bred for 12 winters in Weishan Lake areas.

Methods: The offspring of the adult snails bred in the Weishan Lake that were originated from the Yangzhou section of the Yangtze River was defined as the experiment group, while uninfected, adult snails captured from the marshland of the Yangzhou section of the Yangtze River served as the control group. Snails were dissected and intact testicular and ovarian specimens were sampled, routinely fixed, dehydrated, embedded, polymerized in an oven and sliced on an ultramicrotome. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019088DOI Listing
October 2019

[Identification and functional study of the epidermal growth factor receptor gene].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Apr;32(2):123-131

State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering,Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai 200433, China.

Objective: To characterize the epidermal growth factor receptor () gene in ( gene) and investigate the role of the gene in regulating the growth, reproductive system, maturation and fecundity of .

Methods: Rapid amplification of cDNA ends (RACE) was performed to obtain the full length of the gene, and the gene expression was quantified in different developmental stages of using a quantitative real-time PCR (qPCR) assay. The tissue localization of the gene was detected in 22-day parasite using whole-mount hybridization (WISH). Read More

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http://dx.doi.org/10.16250/j.32.1374.2019300DOI Listing

Condition dependence of phenotypic integration and the evolvability of genitalic traits in a neriid fly.

Biol Lett 2020 May 27;16(5):20200124. Epub 2020 May 27.

Evolution and Ecology Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

The spectacular diversity of insect male genitalia, and their relative insensitivity to the environment, have long puzzled evolutionary biologists and taxonomists. We asked whether the unusual evolvability of male genitalia could be associated with low morphological integration of genitalic traits, by comparison with male somatic traits and female traits. We also asked whether this pattern was robust to variation in resource availability during development, which affects adult condition. Read More

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http://dx.doi.org/10.1098/rsbl.2020.0124DOI Listing

and act redundantly for ovarian-to-testicular fate reprogramming in the absence of in mouse sex reversals.

Elife 2020 May 26;9. Epub 2020 May 26.

Université Côte d'Azur, CNRS, Inserm, iBV, Nice, France.

In mammals, testicular differentiation is initiated by transcription factors SRY and SOX9 in XY gonads, and ovarian differentiation involves R-spondin1 (RSPO1) mediated activation of WNT/β-catenin signaling in XX gonads. Accordingly, the absence of in XX humans and mice leads to testicular differentiation and female-to-male sex reversal in a manner that does not require or in mice. Here we show that an alternate testis-differentiating factor exists and that this factor is . Read More

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http://dx.doi.org/10.7554/eLife.53972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250573PMC

Environmental contaminants and male infertility: Effects and mechanisms.

Andrologia 2020 May 24:e13646. Epub 2020 May 24.

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

The escalating prevalence of male infertility and decreasing trend in sperm quality have been correlated with rapid industrialisation and the associated discharge of an excess of synthetic substances into the environment. Humans are inevitably exposed to these ubiquitously distributed environmental contaminants, which possess the ability to intervene with the growth and function of male reproductive organs. Several epidemiological reports have correlated the blood and seminal levels of environmental contaminants with poor sperm quality. Read More

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http://dx.doi.org/10.1111/and.13646DOI Listing

Evaluation of Mn exposure in the male reproductive system and its relationship with reproductive dysfunction in mice.

Toxicology 2020 May 20:152504. Epub 2020 May 20.

Laboratory of Embryotoxicology, Department of Cell Biology, Federal University of Paraná, Curitiba, PR, Brazil.

Manganese (Mn) is essential for animal development and homeostasis. However, anthropogenic activities increase the concentration of Mn in the environment and lead to increased risk of exposure to high doses of the metal. Thus, this study aimed to evaluate the effect of high doses of Mn on the male reproductive system of swiss mice. Read More

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http://dx.doi.org/10.1016/j.tox.2020.152504DOI Listing

Unmeshed split-thickness SKIN grafts for penile plastic in patients with paraffinoma.

Urol Case Rep 2020 Sep 12;32:101249. Epub 2020 May 12.

Medical University Pleven, "Georgi Kochev"8A str, 5800, Bulgaria.

Paraffinoma of male genitalia (PMG) is a chronic granulomatous reaction to a "foreign body" developed after injection of exogenous substances (ES). There are many plastic surgical techniques for aesthetic and functional recovery of affected tissues. We report here use of unmeshed split-thickness skin grafts (unmSTSG) in patients with genital paraffinoma. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232093PMC
September 2020

Transcriptome Analysis of Male Reproductive Tract in Indirect Response to Elevated CO and Heat Wave.

Front Physiol 2020 5;11:417. Epub 2020 May 5.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.

Increase in atmospheric CO directly affects the insect physiology and behavior, and indirectly affects the herbivorous insects by affecting their hosts. The increase in atmospheric CO is accompanied by an increase in temperature and heat waves. LeSage is a natural enemy of (common ragweed). Read More

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http://dx.doi.org/10.3389/fphys.2020.00417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215069PMC

Walking-Evoked Erection in Patients with Lumbar Degenerative Diseases: Eight Cases and Review of the Literature.

Asian Spine J 2020 May 21. Epub 2020 May 21.

Spinal Disorders Center, Fujieda Heisei Memorial Hospital, Shizuoka, Japan.

Study Design: Narrative review with a case illustration.

Purpose: The purpose of this study was to evaluate the pathogenesis and outcome of therapy for walking-evoked erection in patients with lumbar degenerative diseases.

Overview Of Literature: Cauda equina compression due to lumbar degenerative diseases rarely cause a walking-evoked erection; however, no review has been undertaken of walking-evoked erection in patients with lumbar degenerative diseases. Read More

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http://dx.doi.org/10.31616/asj.2019.0340DOI Listing

Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection.

Am J Physiol Endocrinol Metab 2020 06 18;318(6):E878-E880. Epub 2020 May 18.

Azrieili Faculty of Medicine in Galilee, Bar-Ilan University, Safed, Israel.

The viral pandemic of the coronavirus disease 2019 (COVID-19), generated by a novel mutated severe acute respiratory syndrome coronavirus (SARS-CoV-2), has become a serious worldwide public health emergency, evolving exponentially. While the main organ targeted in this disease is the lungs, other vital organs, such as the heart and kidney, may be implicated. The main host receptor of the SARS-CoV-2 is angiotensin converting enzyme 2 (ACE2), a major component of the renin-angiotensin-aldosterone system (RAAS). Read More

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http://dx.doi.org/10.1152/ajpendo.00183.2020DOI Listing

Post Circumcision Corona Obliteration.

J Pediatr Urol 2020 Apr 21. Epub 2020 Apr 21.

Urology Unit, Schneider Children's Hospital Medical Center of Israel, Petah Tikva, Israel. Electronic address:

Objective: Abnormal healing after neonatal ritual circumcision is a source of significant concern to patients' parents and their caregivers. This report presents a series of male infants who underwent ritual circumcision and subsequently developed obliteration of the normally distinct structure of the corona.

Methods: We report a case series of infants recruited from the community and a medical center. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.04.017DOI Listing

Developmental Exposure to Tetrabromobisphenol A Has Minimal Impact on Male Rat Reproductive Health.

Reprod Toxicol 2020 May 13;95:59-65. Epub 2020 May 13.

Reproductive Developmental Biology Group, Reproduction and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address:

The flame retardant and plasticizer, tetrabromobisphenol-A (TBBPA) has rapidly become a common component in the manufacture of circuit boards and plastics worldwide. It is also an analog of bisphenol A (BPA), an endocrine disrupting chemical identified by the Endocrine Society. As such, TBBPA needs to be investigated for similar potential human health risks. Read More

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http://dx.doi.org/10.1016/j.reprotox.2020.05.003DOI Listing

Integrative genome-wide analysis reveals the role of WIP proteins in inhibition of growth and development.

Commun Biol 2020 May 15;3(1):239. Epub 2020 May 15.

Institute of Plant Sciences Paris-Saclay (IPS2), INRAE, CNRS, Université Evry, Université de Paris, Université Paris-Saclay, 91405, Orsay, France.

In cucurbits, CmWIP1 is a master gene controlling sex determination. To bring new insight in the function of CmWIP1, we investigated two Arabidopsis WIP transcription factors, AtWIP1/TT1 and AtWIP2/NTT. Using an inducible system we showed that WIPs are powerful inhibitor of growth and inducer of cell death. Read More

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http://dx.doi.org/10.1038/s42003-020-0969-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229033PMC

CCL20-CCR6 axis directs sperm-oocyte interaction and its dysregulation correlates/associates with male infertility.

Biol Reprod 2020 May 15. Epub 2020 May 15.

Department of Dermatology, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, Germany.

The interaction of sperm with the oocyte is pivotal during the process of mammalian fertilization. The limited numbers of sperm that reach the fallopian tube as well as anatomic restrictions indicate that human sperm-oocyte encounter is not a matter of chance but a directed process. Chemotaxis is the proposed mechanism for re-orientating sperm towards the source of a chemoattractant, and hence to the oocyte. Read More

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http://dx.doi.org/10.1093/biolre/ioaa072DOI Listing

Administration of sodium hydrosulfide reduces remote organ injury by an anti-oxidant mechanism in a rat model of varicocele.

Iran J Basic Med Sci 2020 Feb;23(2):236-243

Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Infertility in varicocele may have an adverse outcome on the future life of an infertile male. This study was designed to investigate whether varicocele affects remote organs, including the kidney, liver, and brain. We have also evaluated the protective effects of NaHS administration on the structure and function of these organs. Read More

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http://dx.doi.org/10.22038/IJBMS.2019.39727.9412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211358PMC
February 2020
0.604 Impact Factor

Short- and long-term exposure to methamidophos impairs spermatogenesis in mice.

Reprod Biol 2020 May 13. Epub 2020 May 13.

Department of Pharmacology, Laboratory of Physiology and Pharmacology of Reproduction, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Methamidophos (MET) is a pesticide that has toxic properties, including effects on fertility. This study aimed to assess the joint action of treatment time and exposure to methamidophos on the male reproductive system. MET was orally administered to adult male Swiss mice at a dose of 0. Read More

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http://dx.doi.org/10.1016/j.repbio.2020.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218378PMC

Tumor of the epididymis: an uncommon presentation of disseminated coccidioidomycosis.

Rev Inst Med Trop Sao Paulo 2020 11;62:e24. Epub 2020 May 11.

Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico.

Coccidioidomycosis is an endemic disease of arid regions in the Western hemisphere. Its clinical presentation varies from asymptomatic nodules on chest x-rays to disseminated disease. We present the case of a 48-year-old man with a hard and heterogeneous tumor in the posterior aspect of the right testis. Read More

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http://dx.doi.org/10.1590/s1678-9946202062024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232960PMC

Developmental programming: intrauterine caloric restriction promotes upregulation of mitochondrial sirtuin with mild effects on oxidative parameters in the ovaries and testes of offspring.

Reprod Fertil Dev 2020 May;32(8):763-773

Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Prédio Anexo, Floresta, Porto Alegre, RS, 90035-003, Brazil; and Programa de Pós-graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências, Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Prédio Anexo, Floresta, Porto Alegre, RS, 90035-003, Brazil; and Programa de Pós-graduação em Ciências Biológicas: Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, R. Sarmento Leite, n° 500, Farroupilha, Porto Alegre, RS, 90050-170, Brazil; and Corresponding author. Email:

According to the developmental origins of health and disease (DOHaD) hypothesis, changes in the maternal environment are known to reprogram the metabolic response of offspring. Known for its redox modulation, caloric restriction extends the lifespan of some species, which contributes to diminished cellular damage. Little is known about the effects of gestational caloric restriction, in terms of antioxidant parameters and molecular mechanisms of action, on the reproductive organs of offspring. Read More

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http://dx.doi.org/10.1071/RD19384DOI Listing

Contrast-enhanced ultrasound evaluation of the prostate before transrectal ultrasound-guided biopsy can improve diagnostic sensitivity: A STARD-compliant article.

Medicine (Baltimore) 2020 May;99(19):e19946

Department of Ultrasound, The First Affiliated Hospital of Hainan Medical University, No. 31, Longhua Road, Haikou 570102, China.

To conduct a STARD-compliant validity that the contrast-enhanced ultrasound (CEUS) evaluation of prostate for the improvement of positive rate of biopsy and diagnostic efficiency of prostate carcinoma (PCa).Data of 137 patients with suspected PCa who underwent relevant examinations and treatment were reviewed, and 82 of 137 patients were finally included. The patients consisted of Group 1 (26 patients) and Group 2 (42 patients) according to which they underwent transrectal ultrasound (TRUS) biopsy selected from CEUS evaluation of the prostate and who underwent TRUS-guided biopsy directly. Read More

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http://dx.doi.org/10.1097/MD.0000000000019946DOI Listing

[PSMA-based theranostics for prostate cancer : From imaging to treatment].

Urologe A 2020 May;59(5):617-625

Klinik und Poliklinik für Nuklearmedizin, Universitätsmedizin Rostock, Rostock, Deutschland.

Background: In recent years nuclear medicine theranostics using radiolabeled prostate-specific membrane antigen (PSMA) ligands have gained increasing importance in the management of prostate cancer.

Aim: The aim of this work is to highlight the value of theranostic concepts using radiolabeled PSMA ligands for both the diagnostic work-up and treatment of advanced prostate cancer.

Material And Methods: The currently available knowledge in the literature is summarized and presented. Read More

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http://dx.doi.org/10.1007/s00120-020-01193-xDOI Listing

Revision of the Herbulot, 1966 group of genera with description of two new genera, ten new species, and two new subspecies (Lepidoptera, Geometridae, Ennominae, Cassymini).

Zookeys 2020 22;929:53-77. Epub 2020 Apr 22.

Department of Agriculture, Environment and Food Sciences, University of Molise, Via Francesco De Sanctis Campobasso, Italy.

The genus Herbulot, 1966 is revised. Two new genera are described: Hausmann & Tujuba, (type species: Ectropis ? subaurata Warren, 1899), and Hausmann & Tujuba, (type species: Hausmann & Tujuba, ). Ten new species and two new subspecies are described: Hausmann & Tujuba, , from western Africa, Hausmann & Tujuba, , from Kenya, Hausmann & Tujuba, , from Zambia, Hausmann & Tujuba, , from Tanzania, Hausmann & Tujuba, , from Kenya, Hausmann & Tujuba, , from Kenya, Hausmann & Tujuba, , from Zambia, Hausmann & Tujuba, , from South Africa, Hausmann & Tujuba, , from Zambia, Tanzania, Ethiopia, Hausmann & Tujuba, , from Ethiopia, Hausmann & Tujuba, , from Zambia and Malawi, and Hausmann & Tujuba, from Ethiopia. Read More

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http://dx.doi.org/10.3897/zookeys.929.50391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192960PMC

Description of six new large species of Lynch-Arribálzaga, 1891 and redescription of (Fluke, 1945) (Diptera, Syrphidae, Syrphinae).

Zookeys 2020 22;929:19-51. Epub 2020 Apr 22.

Grupo de Entomología, Universidad de Antioquia, Calle 67 # 53-108, Medellín, Colombia Universidad de Antioquia Medellín Colombia.

The morphological similarities between five new large species and Fluke are characterized and presented. Six new species of (10-12 mm long) are described: Montoya & Wolff, (Colombia), Montoya, (Colombia), Montoya & Wolff, (Colombia), Montoya, (México), Montoya, (Costa Rica), and Thompson, (Costa Rica). The genus Fluke is re-diagnosed and, redescribed. Read More

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http://dx.doi.org/10.3897/zookeys.929.37666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192955PMC

Incidental Testicular Pathologies in Patients With Idiopathic Hydrocele Testis: Is Preoperative Scrotal Ultrasound Justified?

Anticancer Res 2020 May;40(5):2861-2864

Department of Urology, Medical University Innsbruck, Innsbruck, Austria

Background/aim: Hydrocele testis is a common disease with a prevalence of 1% in adults. Although it can be diagnosed by physical examination, scrotal ultrasound represents a standard diagnostic tool, to exclude underlying pathologies among them testicular or scrotal malignancies.

Patients And Methods: We conducted a retrospective analysis of 156 patients aged between 20 and 60 years who underwent surgical hydrocelectomy between 2003 and 2018. Read More

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http://dx.doi.org/10.21873/anticanres.14261DOI Listing

Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes.

Sci China Life Sci 2020 Apr 30. Epub 2020 Apr 30.

Beijing Advanced Innovation Center for Genomics, Department of Obstetrics and Gynecology, Third Hospital, College of Life Sciences, Peking University, Beijing, 100871, China.

Being infected by SARS-CoV-2 may cause damage to multiple organs in patients, such as the lung, liver and heart. Angiotensin-converting enzyme 2 (ACE2), reported as a SARS-CoV-2 receptor, is also expressed in human male testes. This suggests a potential risk in human male reproductive system. Read More

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http://dx.doi.org/10.1007/s11427-020-1705-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195615PMC

Male postabdomen reveals ancestral traits of Megasecoptera among winged insects.

Arthropod Struct Dev 2020 Apr 30;57:100944. Epub 2020 Apr 30.

Senckenberg Natural History Collections Dresden, Museum of Zoology, Königsbrücker Landstrasse 159, 01109 Dresden, Germany.

External male genitalia of insects are greatly diverse in form and frequently used in evolutionary context and taxonomy. Therefore, our proper recognition of homologous structures among various groups from Paleozoic and extant insect taxa is of crucial interest, allowing to understand the key steps in insect evolution. Here, we reveal structural details of two Late Carboniferous representatives of Megasecoptera (families Bardohymenidae and Brodiopteridae), such as the presence of separated coxal plates VIII and ventral expansions of coxal lobes IX. Read More

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http://dx.doi.org/10.1016/j.asd.2020.100944DOI Listing

Effect of quinestrol on body weight, vital organs, biochemicals and genotoxicity in adult male lesser bandicoot rat, Bandicota bengalensis.

Pestic Biochem Physiol 2020 May 19;165:104544. Epub 2020 Feb 19.

Department of Mathematics, Statistics & Physics, Punjab Agricultural University, Ludhiana 141004, India.

The present study was aimed to evaluate the toxic effects of quinestrol (a synthetic estradiol) in male lesser bandicoot rat, Bandicota bengalensis. Effect was studied on body weight, weight of vital organs, changes in level of biochemical parameters and genotoxicity. Feeding of bait containing 0. Read More

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http://dx.doi.org/10.1016/j.pestbp.2020.02.010DOI Listing

Prediction of microdissection testicular sperm extraction outcome in men with idiopathic nonobstruction azoospermia.

Medicine (Baltimore) 2020 May;99(18):e19934

Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun, China.

The aim of the present study is to assess whether the preoperative clinical indicators have an impact on sperm retrieval rate (SRR) in men with idiopathic nonobstructive azoospermia (NOA).We retrospectively studied 241 consecutive men with NOA who underwent microdissection testicular sperm extraction from 2016 to 2019 in the Reproductive Medicine Center, including 154 patients diagnosed with idiopathic NOA. They were grouped according to preoperative indicators, including average testicular volume, follicle-stimulating hormone (FSH), luteinizing hormone, Testosterone (T), and pathology, respectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000019934DOI Listing

Hydrocele in recurrent acute pancreatitis caused by testicular venous obstruction: A case report of a rare complication (CARE-compliant).

Medicine (Baltimore) 2020 May;99(18):e19738

Division of Gastroenterology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University.

Rationale: Scrotal swelling is a rare complication of acute pancreatitis. It had been explained by fluid accumulation in scrotum originated from abdomen. Here we demonstrated a case of recurrent pancreatitis with hydrocele caused by impaired testicular venous drainage. Read More

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http://dx.doi.org/10.1097/MD.0000000000019738DOI Listing

Regenerative potential of prostate luminal cells revealed by single-cell analysis.

Science 2020 05;368(6490):497-505

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Androgen deprivation is the cornerstone of prostate cancer treatment. It results in involution of the normal gland to ~90% of its original size because of the loss of luminal cells. The prostate regenerates when androgen is restored, a process postulated to involve stem cells. Read More

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http://dx.doi.org/10.1126/science.aay0267DOI Listing
May 2020
31.477 Impact Factor

Male Hypogonadism and Disorders of Sex Development.

Front Endocrinol (Lausanne) 2020 15;11:211. Epub 2020 Apr 15.

Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE), CONICET-FEI-División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.

Disorders of Sex Development (DSD) are congenital anomalies in which there is a discordance between chromosomal, genetic, gonadal, and/or internal/external genital sex. In XY individuals, the process of fetal sex differentiation can be disrupted at the stage of gonadal differentiation, resulting in gonadal dysgenesis, a form of early fetal-onset primary hypogonadism characterized by insufficient androgen and anti-Müllerian hormone (AMH) production, which leads to the development of ambiguous or female genitalia. The process of sex differentiation can also be disrupted at the stage of genital differentiation, due to isolated defects in androgen or AMH secretion, but not both. Read More

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http://dx.doi.org/10.3389/fendo.2020.00211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174651PMC

Remote ischemic conditioning protects against testicular ischemia∕reperfusion injury in rats.

Acta Cir Bras 2020 27;35(2):e202000203. Epub 2020 Apr 27.

Centro Universitário do Estado do Pará, Brazil.

Purpose To evaluate the effect of remote ischemic conditioning associated to N-acetylcysteine (NAC) on testicular ischemia∕reperfusion (I∕R) injury in rats. Methods Twenty-five adult male Wistar rats were randomly distributed into five experimental groups (n=5), as follows: Sham, I∕R, Perconditioning (PER), NAC and PER+NAC. Two-hour ischemia was induced by rotating the left testis 720° to clockwise direction, followed by 4 hours of reperfusion. Read More

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http://dx.doi.org/10.1590/s0102-865020200020000003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184938PMC

Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice.

Elife 2020 Apr 29;9. Epub 2020 Apr 29.

Embryotools, Parc Cientific de Barcelona, Barcelona, Spain.

The developmental potential of early embryos is mainly dictated by the quality of the oocyte. Here, we explore the utility of the maternal spindle transfer (MST) technique as a reproductive approach to enhance oocyte developmental competence. Our proof-of-concept experiments show that replacement of the entire cytoplasm of oocytes from a sensitive mouse strain overcomes massive embryo developmental arrest characteristic of non-manipulated oocytes. Read More

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http://dx.doi.org/10.7554/eLife.48591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259950PMC

First record and taxonomic description of the genus (Fabricius) (Lepidoptera: Noctuidae: Plusiinae) from Pakistan.

Saudi J Biol Sci 2020 May 13;27(5):1375-1379. Epub 2019 Dec 13.

Research Center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia.

Species belonging to genus, Fabricius of the subfamily Plusiinae which are polyphagous in nature and pest of vegetables, foods, legumes, fodder, fruits, ornamental plants and cotton crops. Samples were collected from different localities of district Bahawalpur. For collection, comprehensive and comparative surveys were carried out during 2017-18 on taxonomic account of species of the genus Fabricius and resulted identified one species (Fabricius) first time from Pakistan. Read More

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http://dx.doi.org/10.1016/j.sjbs.2019.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182779PMC
May 2020
0.741 Impact Factor

Integrative and Analytical Review of the 5-Alpha-Reductase Type 2 Deficiency Worldwide.

Appl Clin Genet 2020 14;13:83-96. Epub 2020 Apr 14.

Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia, do Departamento de Clínica Médica, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Introduction: The conversion of testosterone into dihydrotestosterone is catalyzed by the 5α-reductase type 2 enzyme which plays a crucial role in the external genitalia virilization. It is encoded by the gene. Allelic variants in this gene cause a 46,XY DSD with no genotype-phenotype relationship. Read More

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http://dx.doi.org/10.2147/TACG.S198178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167369PMC

Mating changes the genital microbiome in both sexes of the common bedbug across populations.

Proc Biol Sci 2020 May 29;287(1926):20200302. Epub 2020 Apr 29.

Animal Population Ecology, Animal Ecology I, University of Bayreuth, Universitätsstraße 30, 95440 Bayreuth, Germany.

Many bacteria live on host surfaces, in cells and in specific organ systems. In comparison with gut microbiomes, the bacterial communities of reproductive organs (genital microbiomes) have received little attention. During mating, male and female genitalia interact and copulatory wounds occur, providing an entrance for sexually transmitted microbes. Read More

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http://dx.doi.org/10.1098/rspb.2020.0302DOI Listing

Venereal Transmission of Vesicular Stomatitis Virus by Midges.

Pathogens 2020 Apr 24;9(4). Epub 2020 Apr 24.

United States Department of Agriculture, Agricultural Research Service, Arthropod-Borne Animal Diseases Research Unit, Manhattan, KS 66502, USA.

biting midges are well-known agricultural pests and transmission vectors of arboviruses such as vesicular stomatitis virus (VSV). The epidemiology of VSV is complex and encompasses a broad range of vertebrate hosts, multiple routes of transmission, and diverse vector species. In temperate regions, viruses can overwinter in the absence of infected animals through unknown mechanisms, to reoccur the next year. Read More

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http://dx.doi.org/10.3390/pathogens9040316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238210PMC

Exogenous melatonin improves cotton (Gossypium hirsutum L.) pollen fertility under drought by regulating carbohydrate metabolism in male tissues.

Plant Physiol Biochem 2020 Jun 8;151:579-588. Epub 2020 Apr 8.

College of Agriculture, Nanjing Agricultural University, Nanjing, 210095, PR China; Jiangsu Collaborative Innovation Center for Modern Crop Production (JCIC-MCP), Nanjing Agricultural University, Nanjing, 210095, Jiangsu, China. Electronic address:

Although exogenous melatonin can enhance the drought tolerance of plants, reports on the role of melatonin in drought tolerance in male reproductive organs are limited. To explore this, a pot experiment was conducted with cotton cultivar Yuzaomian 9110 to study the effects of exogenous melatonin (100, 200, and 1000 μM) on male fertility and related carbohydrate metabolism in anther under drought. Results showed that drought inhibited the translocation of carbon assimilates to anthers, however, melatonin application (100 and 200 μM) significantly improved the translocation of carbon assimilates to drought-stressed anthers. Read More

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http://dx.doi.org/10.1016/j.plaphy.2020.04.001DOI Listing

Differential Small RNA Responses against Co-Infecting Insect-Specific Viruses in Mosquitoes.

Viruses 2020 Apr 21;12(4). Epub 2020 Apr 21.

Institut Pasteur, Viruses and RNA Interference Unit, CNRS Unité Mixte de Recherche 3569, 75724 Paris Cedex 15, France.

The mosquito antiviral response has mainly been studied in the context of arthropod-borne virus (arbovirus) infection in female mosquitoes. However, in nature, both female and male mosquitoes are frequently infected with insect-specific viruses (ISVs). ISVs are capable of infecting the reproductive organs of both sexes and are primarily maintained by vertical transmission. Read More

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http://dx.doi.org/10.3390/v12040468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232154PMC

A novel homozygous mutation in WDR19 induces disorganization of microtubules in sperm flagella and nonsyndromic asthenoteratospermia.

J Assist Reprod Genet 2020 Apr 23. Epub 2020 Apr 23.

Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Background: Asthenoteratospermia with multiple morphological abnormalities in the sperm flagella (MMAF) is a significant cause of male infertility. WDR19 is a core component in the IFT-A complex and has a critical role in intraflagellar transport. However, the role of WDR19 mutations in male infertility has yet to be examined. Read More

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http://dx.doi.org/10.1007/s10815-020-01770-1DOI Listing