Search Our Scientific Publications & Authors

Radiol Case Rep 2019 Apr 16;14(4):427-429. Epub 2019 Jan 16.

General Radiologist at CediMed and Hospital Pablo Tobón Uribe, Radiology Professor at Universidad CES and Universidad Pontificia Bolivariana, Medellín, Colombia.

Breast hemangioma is a rare benign tumor in female and extremely rare in males. They are part of vascular tumors. Here, we described the case of a male patient who had a breast hemangioma for 30 years that was diagnosed incidentally in a thorax and abdomen tomography. Read More

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r = 0. Read More

Sensors (Basel) 2019 Jan 10;19(2). Epub 2019 Jan 10.

Department of Radiology, Mayo Clinic College of Medicine & Science, Rochester, MN 55905, USA.

Vascular networks can provide invaluable information about tumor angiogenesis. Ultrafast Doppler imaging enables ultrasound to image microvessels by applying tissue clutter filtering methods on the spatio-temporal data obtained from plane-wave imaging. However, the resultant vessel images suffer from background noise that degrades image quality and restricts vessel visibilities. Read More

Int J Colorectal Dis 2019 Jan 8. Epub 2019 Jan 8.

Department of Epidemiology and Biostatistics, First Affiliated Hospital, Army Medical University, 30 Gaotanyan Street Shapingba District, Chongqing, 400038, China.

Purpose: To investigate the incidence and the associated factors for bone metastases (BM) development and prognosis in initial colorectal cancer (CRC) with a large sample using Surveillance, Epidemiology, and End Results (SEER) cohort.

Methods: Primary CRC patients, who were initially diagnosed between 2010 and 2015 in the SEER database, were included to analyze BM incidence and risk factors for BM occurrence. The patients with at least 1-year follow-up were involved to investigate the prognostic factors for BM. Read More

Arch Soc Esp Oftalmol 2018 Dec 18. Epub 2018 Dec 18.

Servicio de Oftalmología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, España.

Two clinical cases of orbital metastasis are presented. The first is a 63 year-old male with a recent loss of visual acuity associated with binocular diplopia. Neuroimaging tests revealed a tumour of aggressive features with intraconal extension and bone invasion. Read More

Clin Nucl Med 2019 Feb;44(2):140-141

From the Departments of Nuclear Medicine, and.

F-Fluorocholine is a relatively new, extremely versatile radiotracer for detecting proliferative or mitogenic activity. Its diagnostic potential has been explored in cancers of the prostate, liver, esophagus, breast, brain, and lung, as well as lymphoma, sarcoma, melanoma, and parathyroid adenomas. The authors present a case where fluorocholine PET/CT performed for characterizing a space-occupying lesion in the brain revealed intensely tracer-avid skull lesions with intracranial soft tissue component and multiple other skeletal lesions. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13706

Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

Rational: Occult breast cancer (OBC) is an extremely rare breast cancer and is defined by the presence of axillary metastasis without a primary tumor in the breasts or any abnormality on radiologic examination.

Patient Concerns: This case report presents a 49-year-old man who was diagnosed with male OBC, which first manifested as an axillary lymph node metastasis followed by the emergence of infraclavicular lymph node metastasis. Neither the breast nor other organs had any abnormality. Read More

EJNMMI Res 2018 Dec 12;8(1):108. Epub 2018 Dec 12.

Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland.

Background: Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer positron emission tomography (PET) protocol. Five male patients with biochemical relapse of prostate adenocarcinoma underwent four whole-body time-of-flight PET/CT scans within 2 h after tracer injection. Read More

Anticancer Res 2018 Dec;38(12):6797-6800

Departments of Radiology, Neurology and Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.

Background/aim: Radiotherapy for carcinoma invasion of the sacrum (CIS) is an alternative treatment to surgery in patients with advanced, inoperable tumors or those not medically eligible for resection of the neoplasm. Herein we present an observational study of patients with imaging-confirmed CIS who were treated non-operatively with radiation.

Patients And Methods: A retrospective chart review of CIS patients treated with palliative radiotherapy (PR) during a 9-year period (2004-2013) was performed. Read More

Anticancer Res 2018 Dec;38(12):6639-6652

Department of Surgery, Tor Vergata University Hospital, Rome, Italy.

Background/aim: Positron emission tomography/computed tomography (PET/CT) with F-fluorodeoxyglucose (18F-FDG) has recently been used to investigate lymph node (LN) metastases and several predictive features in patients with breast cancer (BC). The aim of this study was to assess the value of this non-invasive imaging procedure for axillary staging.

Patients And Methods: Fifty patients with early primary unilateral, locally advanced, or recurrent invasive operable BC were enrolled. Read More

Cancer Sci 2019 Feb 17;110(2):509-518. Epub 2019 Jan 17.

Laboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan.

Lymph node (LN) dissection is a crucial procedure for cancer staging, diagnosis and treatment, and for predicting patient survival. Activation of lung metastatic lesions after LN dissection has been described for head and neck cancer and breast cancer. Preclinical studies have reported that dissection of a tumor-bearing LN is involved in the activation and rapid growth of latent tumor metastases in distant organs, but it is also important to understand how normal (non-tumor-bearing) LN resection influences secondary cancer formation. Read More

Am J Case Rep 2018 Nov 30;19:1425-1429. Epub 2018 Nov 30.

Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL, USA.

BACKGROUND Male breast hemangioma is a rare benign neoplasm that is usually excised for definitive diagnosis. CASE REPORT In our case report, we present a male octogenarian with multiple comorbidities who presented with a large palpable mass in his right breast. The diagnostic imaging studies were suggestive of a benign tumor, with a BI-RADS (Breast Imaging Reporting and Data System) score of 3. Read More

Nucl Med Commun 2019 Jan;40(1):22-29

Department of Nuclear Medicine, The Ottawa Hospital.

Background: Trastuzumab (T) and anthracycline (A)-based chemotherapy is considered the standard of care in human epidermal growth factor receptor-2+ overexpressing breast cancer, but requires monitoring for known cardiotoxicity using left ventricular (LV) ejection fraction (EF) every 3-4 months during treatment. It is not conclusively established whether diastolic dysfunction (DD) precedes LVEF decrease in patients developing trastuzumab-induced cardiotoxicity (TIC).

Objective: The aim was to elucidate whether DD precedes LVEF decrease in trastuzumab-treated patients being monitored with radionuclide multigated acquisition for TIC. Read More

J Am Coll Radiol 2018 Nov;15(11S):S313-S320

Panel Chair, Emory University Hospital, Atlanta, Georgia.

Although the majority of male breast problems are benign with gynecomastia as the most common etiology, men with breast symptoms and their referring providers are typically concerned about whether or not it is due to breast cancer. If the differentiation between benign disease and breast cancer cannot be made on the basis of clinical findings, or if the clinical presentation is suspicious, imaging is indicated. The panel recommends the following approach to breast imaging in symptomatic men. Read More

No Shinkei Geka 2018 Oct;46(10):865-873

Division of Neurosurgery, Shizuoka Cancer Center.

Background: Skull-base metastases frequently cause progressive ipsilateral disturbances of cranial nerves or pain, resulting in poor quality of life in patients with cancer. Magnetic resonance(MR)imaging is the method to detect skull-base metastases, which demonstrates focal lesions of low-intensity signal and enhancement on T1-weighted MR images.

Methods: We reviewed clinical data and MR images from 127 patients with skull-base metastases diagnosed at Shizuoka Cancer Center Hospital between August 2012 and November 2017. Read More

J Surg Oncol 2018 Dec 27;118(8):1271-1276. Epub 2018 Oct 27.

Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea.

Background And Objectives: The adrenal gland is a frequent site for metastasis, and a solitary adrenal mass is often observed during staging workup or imaging follow-up in patients with extra-adrenal malignancy. To create an appropriate management plan, it is essential to distinguish between benign adrenal lesions and metastasis in patients with extra-adrenal cancer having solitary adrenal masses. Therefore, here we evaluated the predictive factors for adrenal metastasis in patients with extra-adrenal malignancy having solitary adrenal mass. Read More

Technol Cancer Res Treat 2018 01;17:1533033818806472

1 Division of Radiation Oncology, Department of Radiology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Bunkyo-ku, Tokyo, Japan.

Object: This study aimed to clarify the outcomes of stereotactic body radiotherapy for spinal metastases with a uniform dose fractionation schedule in our institution.

Materials And Methods: Patients treated with spine stereotactic body radiotherapy were retrospectively reviewed. The prescribed dose was 24 Gy in 2 fractions. Read More

Oncol Lett 2018 Nov 3;16(5):5583-5590. Epub 2018 Sep 3.

Department of Laboratory Medicine, Inha University College of Medicine, Incheon 22332, Republic of Korea.

The present study was performed to evaluate the efficacy of circulating cystatin-C as a tumor monitoring biomarker at different clinical time points in patients with breast cancer over a long-term follow-up period. In addition, the secretory rate of circulating cystatin-C from cancer tissue was investigated by comparing the blood and tissue expression levels of cystatin-C. Blood samples from healthy volunteers (40 males and 40 females) were obtained at yearly health examinations if laboratory and imaging abnormalities were not detected. Read More

Med Phys 2018 Dec 8;45(12):5411-5419. Epub 2018 Nov 8.

Unit of Medical Physics, Pisa University Hospital "Azienda Ospedaliero-Universitaria Pisana", 56126, Pisa, Italy.

Purpose: While previous studies have demonstrated the feasibility and potential usefulness of quantitative non-Gaussian diffusional kurtosis imaging (DKI) of the brain, more recent research has focused on oncological application of DKI in various body regions such as prostate, breast, and head and neck (HN). Given the need to minimize scan time during most routine magnetic resonance imaging (MRI) acquisitions of body regions, diffusion-weighted imaging (DWI) with only three orthogonal diffusion weighting directions (x, y, z) is usually performed. Moreover, as water diffusion within malignant tumors is generically thought to be almost isotropic, DWI with only three diffusion weighting directions is considered sufficient for oncological application and it represents the de facto standard in body DKI. Read More

Nucl Med Commun 2019 Jan;40(1):63-72

Radiotherapy, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: Male breast cancer (MBC) is a rare malignancy, with recurrence being one of the main adverse predictors for prognosis. The aim of the study was to evaluate the diagnostic and predictive value of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in the setting of suspected recurrence of MBC.

Patients And Methods: Retrospective analysis of PET/CT findings was performed in 23 previously treated, histologically proven patients with MBC (mean age: 59. Read More

Rofo 2018 Nov 8;190(11):1006-1009. Epub 2018 Oct 8.

Diagnostic and Interventional Radiology, Universität Leipzig Medizinische Fakultät, Leipzig, Germany.

Medicine (Baltimore) 2018 Oct;97(40):e12578

Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing.

This study aimed to evaluate the characteristics of parathyroid carcinoma and to validate the diagnostic value of Tc-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography/x-ray computed tomography (SPECT/CT) for differentiating between parathyroid carcinoma and hyperparathyroidism. Four consecutive patients with suspected primary hyperparathyroidism were enrolled in this study and underwent Tc-MIBI SPECT/CT, ultrasonography, enhanced CT, and MRI. Serum parathyroid hormone (PTH) and calcium were measured. Read More

Br J Radiol 2019 Feb 7;92(1094):20180620. Epub 2018 Nov 7.

1 Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka , Kagoshima , Japan.

Objective:: This retrospective study examined whether the primary tumour 18F-FDG uptake features could predict the high-risk of recurrence in differentiated thyroid cancer (DTC) patients.

Methods:: The enrolled 114 DTC patients underwent preoperative F-FDG-PET/CT. SUVmax, SUVmean, metabolic tumour volume (MTV), total lesion glycolysis (TLG) and 6 texture parameters were obtained. Read More

Eur J Nucl Med Mol Imaging 2018 12 27;45(13):2285-2299. Epub 2018 Sep 27.

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK.

Background: Effective anticancer therapy is thought to involve induction of tumour cell death through apoptosis and/or necrosis. [F]ICMT-11, an isatin sulfonamide caspase-3/7-specific radiotracer, has been developed for PET imaging and shown to have favourable dosimetry, safety, and biodistribution. We report the translation of [F]ICMT-11 PET to measure chemotherapy-induced caspase-3/7 activation in breast and lung cancer patients receiving first-line therapy. Read More

Asian Pac J Cancer Prev 2018 Sep 26;19(9):2455-2460. Epub 2018 Sep 26.

Department of Radiological Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait. Email:

Colorectal cancer (CRC) is the third most common type of cancer and also the fourth most common cause of cancer related death in both men and women worldwide. The CRC is considered to be the second killer in Kuwait after breast cancer. Aim: to assess and identify the level of knowledge and awareness of colorectal cancer with regards to risk factors, symptoms and screening/imaging procedures among general public in the State of Kuwait. Read More

Nucl Med Commun 2018 Nov;39(11):1033-1038

Surgery, Breast Surgery, Tokyo Medical and Dental University, Tokyo, Japan.

Purpose: This study investigated the correlation between fluorine-18-fluorodeoxyglucose (F-FDG)-PET/computed tomography (CT) and clinicopathological factors in patients with mucinous breast carcinoma and assessed the feasibility of using F-FDG-PET/CT in evaluating tumors.

Patients And Methods: We retrospectively examined 42 consecutive patients with pathologically proven mucinous breast carcinoma who preoperatively underwent F-FDG-PET/CT. In addition, we compared F-FDG uptake with clinicopathological characteristics. Read More

BMC Cancer 2018 Sep 19;18(1):903. Epub 2018 Sep 19.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

Background: Magnetic resonance imaging (MRI) has improved capacity to visualize tumor and soft tissue involvement in head and neck cancers. Using advanced MRI, we can interrogate cell density using diffusion weighted imaging, a quantitative imaging that can be used during radiotherapy, when diffuse inflammatory reaction precludes PET imaging, and can assist with target delineation as well. Correlation of circulating tumor cells (CTCs) measurements with 3D quantitative tumor characterization could potentially allow selective, patient-specific response-adapted escalation or de-escalation of local therapy, and improve the therapeutic ratio, curing the greatest number of patients with the least toxicity. Read More

PET Clin 2018 Oct 17;13(4):491-503. Epub 2018 Aug 17.

Department of Nuclear Medicine, Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg 69120, Germany; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Centre, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

The skeleton is a common site for cancer metastases. Bone metastases are a major cause of morbidity and mortality and associated with pain, pathologic fractures, spinal cord compression, and decreased survival. Various radionuclides have been used for pain therapy. Read More

Pathol Int 2018 Oct 14;68(10):563-566. Epub 2018 Sep 14.

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

SMARCB1-deficiency has been found in a variety of tumors. Here, we report a SMARCB1-deficient squamous cell carcinoma of a mediastinal cyst. A 53-year-old man was diagnosed with a cyst of the pericardial region in his twenties. Read More

Nucl Med Biol 2018 11 24;66:26-31. Epub 2018 Aug 24.

Department of Chemistry, University of Illinois at Urbana-Champaign, IL 61801, United States of America.

Introduction: Poly (ADP-ribose) polymerase-1 (PARP-1) plays many roles in prostate cancer (PC), such as mediating DNA damage repair, transcriptional regulation and nuclear hormone receptor signaling. Because of this, PARP-1 has been targeted for therapy in PC, and non-invasive imaging of PARP-1 could help predict which patients are likely to respond to such therapy. Several PARP-1 positron emission tomography (PET) imaging agents have been developed and show promise for imaging PARP-1 expression in breast, brain, and lung cancer in small animals, but not as yet in prostate cancer. Read More

Radiol Med 2019 Jan 6;124(1):50-57. Epub 2018 Sep 6.

Department of Radiation Oncology - Gemelli-ART, Catholic University of Rome, School of Medicine, Foundation University Hospital "A. Gemelli", Largo A. Gemelli 8, 00168, Rome, Italy.

Objectives: Recently, radiomic analysis has gained attention as a valuable instrument for the management of oncological patients. The aim of the study is to isolate which features of magnetic resonance imaging (MRI)-based radiomic analysis have to be considered the most significant predictors of metastasis in oncological patients with spinal bone marrow metastatic disease.

Materials And Methods: Eight oncological patients (3 lung cancer; 1 prostatic cancer; 1 esophageal cancer; 1 nasopharyngeal cancer; 1 hepatocarcinoma; 1 breast cancer) with pre-radiotherapy MR imaging for a total of 58 dorsal vertebral bodies, 29 metastatic and 29 non-metastatic were included. Read More

Diagn Cytopathol 2018 Oct 26;46(10):879-882. Epub 2018 Aug 26.

Department of Pathology, West China Hospital of Sichuan University, Chengdu, China.

Fine-needle aspiration (FNA) is commonly used to evaluate both primary thyroid lesions (PTLs) and secondary thyroid neoplasms (STNs). Although STNs are uncommon, metastases from various primary sites particularly the kidney, lung, and breast have been previously described. Giant cell tumor (GCT) is typically found in the metaphyseal-epiphyseal area of long bones that seldom involves thyroid. Read More

World Neurosurg 2018 Dec 23;120:28-35. Epub 2018 Aug 23.

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Objective: To report and describe a modified posterior-only approach (paraspinal approach) for total en bloc spondylectomy (TES) of lumbar spinal tumors.

Methods: From February 2013 to June 2014, 5 patients with lumbar spinal tumors who underwent TES through a posterior-only paraspinal approach were studied retrospectively; operative time, blood loss, complications, neurologic outcomes, and degree of resection were recorded to evaluate the efficacy of this surgical method.

Results: Patients included 3 men and 2 women with a mean age of 48. Read More

Medicine (Baltimore) 2018 Aug;97(34):e11970

Department of Breast Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.

The aim of the present study was to meta-analyze the literature on the diagnostic value of 18-fluorodeoxyglucose (F-FDG) positron emission tomography (PET) with or without computed tomography (CT) in detecting extrahepatic metastases or local residual/recurrent hepatocellular carcinoma (HCC).Systematic review of literature in MEDLINE, Embase, and Cochrane databases was conducted in March 2017, and relevant studies analyzing the diagnostic performance of F-FDG PET with or without CT were meta-analyzed.Meta-analysis was carried out on data from 11 studies involving 572 patients. Read More

No Shinkei Geka 2018 Aug;46(8):683-689

Department of Neurosurgery(Omori), School of Medicine, Faculty of Medicine, Toho University.

Male breast cancer accounts for less than 1.0% of all breast cancer cases, and its brain metastasis is very rare. We encountered a male patient in whom brain metastasis occurred more than 20 years after the development of breast cancer. Read More

Cureus 2018 Jun 18;10(6):e2821. Epub 2018 Jun 18.

Pathology, Florida Hospital, Orlando , USA.

Renal cell carcinoma (RCC) has the propensity to hematogenously metastasize to the lung, bone, or liver, however, metastasis to the esophagus is exceedingly rare. We report a case of ulcerative esophagitis secondary to recurrent metastatic renal cell cancer status post remote nephrectomy. An 82-year-old Caucasian male presented with dark tarry stools for two days, progressive dysphagia to solid food for several weeks and unintentional weight loss. Read More

Clin Imaging 2018 Nov - Dec;52:203-207. Epub 2018 Aug 8.

Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242, United States.

Metastatic disease represents over half of all malignancies in brain parenchyma, and carcinoma when metastatic will often spread to the brain, with lung and breast tumors being the most common culprits. The suggestive features of metastatic disease on magnetic resonance imaging include peritumoral, vasogenic edema and avid postcontrast enhancement. We present the case of a 50-year-old male with an established diagnosis of metastatic adenocarcinoma of the lung treated with erlotinib who developed multiple cystic brain lesions on surveillance MRI. Read More

Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):91-95

Department of Medical Oncology, Barts health NHS Trust, London, UK.

Purpose: The purpose of this study was to report the results of staging primary uveal melanoma with whole-body (18) fluorodeoxyglucose (FDG) positron-emission tomography/computed tomography (PET/CT) and abdominal ultrasound.

Materials And Methods: From January 2012, patients with uveal melanoma over 4 mm in thickness were staged with FDG PET/CT and abdominal ultrasound.

Results: Over 2 years, 108 patients with medium-to-large melanoma underwent dual imaging. Read More

Curr Probl Diagn Radiol 2018 Jul 29. Epub 2018 Jul 29.

Boston University School of Medicine, Boston Medical Center, Section of Breast Imaging, Department of Radiology, Boston, MA.

The male breast is susceptible to a variety of benign and malignant processes, many of which clinically present as a palpable finding, focal pain, or breast enlargement. Gynecomastia is the most common abnormality in the male breast and must be distinguished from malignancy. Imaging of the symptomatic male breast begins with a diagnostic mammogram in a patient ≥25 years and targeted ultrasound in a patient <25 years. Read More

Cell Physiol Biochem 2018 17;48(6):2429-2440. Epub 2018 Aug 17.

National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

Background/aims: The chondroitin sulfate proteoglycan serglycin (SRGN), a hematopoietic cell granule proteoglycan, has been implicated in promoting tumor metastasis; however, the underlying mechanisms remain to be elucidated. The present study aimed to investigate the SRGN gene expression and its regulation as downstream signaling of hypoxia-inducible transcription factor 1 alpha (HIF-1α) in colorectal cancer (CRC) cells and tissues.

Methods: The expression of SRGN was analyzed in CRC specimens for its correlation with progression and metastasis. Read More

Med Phys 2018 Oct 24;45(10):4667-4682. Epub 2018 Sep 24.

Department of Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.

Purpose: The purpose of this study was to estimate the radiation dose to the lung and breast as well as the effective dose from tube current modulated (TCM) lung cancer screening (LCS) scans across a range of patient sizes.

Methods: Monte Carlo (MC) methods were used to calculate lung, breast, and effective doses from a low-dose LCS protocol for a 64-slice CT that used TCM. Scanning parameters were from the protocols published by AAPM's Alliance for Quality CT. Read More

World Neurosurg 2018 Nov 13;119:e991-e996. Epub 2018 Aug 13.

Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA; Veterans Affairs Medical Center, Ann Arbor, Michigan, USA. Electronic address:

Background: Spinal metastases pose significant morbidity. For many histologies, the spine is a frequent site for bone metastases. This predilection is not fully understood, and there are conflicting reports regarding the distribution within the vertebral body itself. Read More

World Neurosurg 2018 Nov 7;119:394-399. Epub 2018 Aug 7.

Department of Neurosurgery, Kumamoto University Hospital, Kumamoto, Japan.

Background: Thyroid-stimulating hormone-secreting pituitary adenomas (TSHomas) are uncommon, and majority of the patients present with symptoms of hyperthyroidism. Herein, we report the first case of TSHoma with differentiated thyroid carcinoma (DTC) that presented with visual disturbance without any clinical feature of hyperthyroidism.

Case Description: A 57-year-old man presented with left temporal hemianopsia of his left eye without any sign of hyperthyroidism. Read More

Hell J Nucl Med 2018 May-Aug;21(2):125-133

Department of Nuclear Medicine, University Hospital of Patras, Patras, Greece, Department of Nuclear Medicine, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Objective: Single photon emission tomography/computed tomography (SPET/CT) is usually recommended after ambiguous whole body bone scan (WBS) findings. We investigated the value of routine 2-field ("near" whole-body) SPET/CT application in breast cancer (BC) patients.

Subjects And Methods: In this prospective study planar WBS and 2-field SPET/CT was performed in 257 consecutive BC patients referred for a bone scan. Read More

Nat Commun 2018 08 6;9(1):3116. Epub 2018 Aug 6.

Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.

Glioblastoma multiforme (GBM) is an aggressive primary brain cancer that includes focal amplification of PDGFRα and for which there are no effective therapies. Herein, we report the development of a genetically engineered mouse model of GBM based on autocrine, chronic stimulation of overexpressed PDGFRα, and the analysis of GBM signaling pathways using proteomics. We discover the tubulin-binding protein Stathmin1 (STMN1) as a PDGFRα phospho-regulated target, and that this mis-regulation confers sensitivity to vinblastine (VB) cytotoxicity. Read More

BMC Oral Health 2018 08 3;18(1):131. Epub 2018 Aug 3.

Department of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, No.666, Buzih Road, Beitun District, Taichung City, 40601, Taiwan.

Background: Radiation dose evaluation is important to cone-beam computed tomography (CBCT) for routine orthodontic treatment planning, especially for a significant proportion of children in orthodontic patients. This study evaluated the patient radiation dose and estimated the radiation cancer risk on dental CBCT according to the calculations by the Monte Carlo simulation method.

Methods: The dental CBCT scanner evaluated in this project was the i- CAT® (Imaging Sciences International Inc. Read More

Radiographics 2018 Sep-Oct;38(5):1289-1311. Epub 2018 Aug 3.

From the Department of Radiology, New York University Langone Medical Center, 160 E 34th St, New York, NY 10016 (Y.G., S.L.H., L.M.); and the Center for Advanced Imaging Innovation and Research, New York University School of Medicine, New York, NY (L.M.).

In detection, treatment, and follow-up, male breast cancer has historically lagged behind female breast cancer. On the whole, breast cancer is less common among men than among women, limiting utility of screening, yet the incidence of male breast cancer is rising, and there are men at high risk for breast cancer. While women at high risk for breast cancer are well characterized, with clearly established guidelines for screening, supplemental screening, risk prevention, counseling, and advocacy, men at high risk for breast cancer are poorly identified and represent a blind spot in public health. Read More

BMJ Case Rep 2018 Aug 1;2018. Epub 2018 Aug 1.

Pathology Department, KK Women's and Children's Hospital, Singapore.

An elderly woman presented with an enlarging left breast lump. Breast imaging revealed a large suspicious mass associated with cystic components. Core biopsy however was non-diagnostic and only revealed necrotic papillary tissue. Read More

J Korean Neurosurg Soc 2018 Sep 1;61(5):633-639. Epub 2018 Aug 1.

Department of Neurosurgery, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju, Korea.

Objective: We investigated the outcomes of repeat stereotactic radiosurgery (SRS) for metastatic brain tumors that locally recurred despite previous SRS, focusing on the tumor control.

Methods: A total of 114 patients with 176 locally recurring metastatic brain tumors underwent repeat SRS after previous SRS. The mean age was 59. Read More

Eur J Nucl Med Mol Imaging 2018 12 28;45(13):2328-2337. Epub 2018 Jul 28.

Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.

Objectives: The purpose of this study was to compare the diagnostic value of a one-step to a two-step staging algorithm utilizing F-FDG PET/MRI in breast cancer patients.

Methods: A total of 38 patients (37 females and one male, mean age 57 ± 10 years; range 31-78 years) with newly diagnosed, histopathologically proven breast cancer were prospectively enrolled in this trial. All PET/MRI examinations were assessed for local tumor burden and metastatic spread in two separate reading sessions: (1) One-step algorithm comprising supine whole-body F-FDG PET/MRI, and (2) Two-step algorithm comprising a dedicated prone F-FDG breast PET/MRI and supine whole-body F-FDG PET/MRI. Read More