4,611 results match your criteria Male Breast Cancer Imaging


Leptomeningeal Carcinomatosis as the Initial Manifestation of Metastatic Disease diagnosed in Postmortem Examination: A Case Series.

P R Health Sci J 2019 Mar;38(1):64-67

Department of Pathology and Laboratory Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico; Administración de Servicios Médicos de Puerto Rico, San Juan, Puerto Rico.

Leptomeningeal carcinomatosis (LMC) refers to the infiltration of malignant cells in the pia-arachnoids. LMC is undiagnosed until autopsy in about 20% of cases. A nonspecific neurologic symptomatology makes diagnosis challenging; especially in the scenario of unknown malignancy. Read More

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March 2019
1 Read

Clinical outcome of cerebrospinal fluid shunts in patients with leptomeningeal carcinomatosis.

World J Surg Oncol 2019 Mar 27;17(1):59. Epub 2019 Mar 27.

Neuro-oncology Clinic, National Cancer Center, Goyang, Republic of Korea.

Background: Leptomeningeal carcinomatosis (LMC) is frequently associated with hydrocephalus, which quickly devastates the performance of the patient. Cerebrospinal fluid (CSF) shunt is a widely accepted treatment of choice, but the clinical outcomes in patients with LMC are not well studied. This study aimed to examine the efficacy of a CSF shunt in patients with LMC. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-019-1
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http://dx.doi.org/10.1186/s12957-019-1595-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438037PMC
March 2019
5 Reads

Double trouble: two cases of dual adrenal pathologies in one adrenal mass.

Endocrinol Diabetes Metab Case Rep 2019 Mar 23;2019. Epub 2019 Mar 23.

St. Vincent's University Hospital and University College Dublin, Dublin, Ireland.

Context Adrenal incidentalomas (AI) represent an increasingly common problem in modern endocrine practice. The diagnostic approach to AIs can be challenging and occasionally reveals surprising features. Here we describe two rare cases of complex adrenal lesions consisting of phaeochromocytomas with synchronous metastases from extra-adrenal primaries. Read More

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http://dx.doi.org/10.1530/EDM-18-0151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432979PMC
March 2019
1 Read

Probabilistic independent component analysis of dynamic susceptibility contrast perfusion MRI in metastatic brain tumors.

Cancer Imaging 2019 Mar 18;19(1):14. Epub 2019 Mar 18.

UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, Los Angeles, CA, USA.

Purpose: To identify clinically relevant magnetic resonance imaging (MRI) features of different types of metastatic brain lesions, including standard anatomical, diffusion weighted imaging (DWI) and dynamic susceptibility contrast (DSC) perfusion MRI.

Methods: MRI imaging was retrospectively assessed on one hundred and fourteen (N = 114) brain metastases including breast (n = 27), non-small cell lung cancer (NSCLC, n = 43) and 'other' primary tumors (n = 44). Based on 114 patient's MRI scans, a total of 346 individual contrast enhancing tumors were manually segmented. Read More

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http://dx.doi.org/10.1186/s40644-019-0201-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423873PMC
March 2019
1 Read

Radial incision and cutting method using a transanal approach for treatment of anastomotic strictures following rectal cancer surgery: a case report.

World J Surg Oncol 2019 Mar 14;17(1):48. Epub 2019 Mar 14.

Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medicine, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima, 890-8520, Japan.

Background: Development of an anastomotic stricture following rectal cancer surgery is not uncommon. Such strictures are usually managed by manual or instrumental dilatation techniques that are often insufficiently effective, as evidenced by the high recurrence rate. Various surgical procedures using minimally invasive approaches have also been reported. Read More

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http://dx.doi.org/10.1186/s12957-019-1592-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419360PMC
March 2019
2 Reads

Potential Impact of the Interval Between Imaging and Whole-brain Radiotherapy in Patients With Relatively Favorable Survival Prognoses.

Anticancer Res 2019 Mar;39(3):1343-1346

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany

Background/aim: The interval between diagnostic imaging and whole-brain radiotherapy (WBRT) had no significant impact on survival in our previous study of WBRT for brain metastases. Since median survival time was only 2 months, a potentially negative impact by delaying treatment could have been missed. Therefore, we performed an additional analysis of patients surviving at least 4 months following irradiation. Read More

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http://dx.doi.org/10.21873/anticanres.13247DOI Listing
March 2019
1 Read

Costal chondrosarcoma mimicking a breast cancer: Case report and review of literature.

Int J Surg Case Rep 2019 14;56:37-39. Epub 2019 Feb 14.

Department of Surgical Oncologists, Salah-Azaiez Institute, Boulevard of 9-Avril, 1001 Tunis, Tunisia.

Introduction: Chondrosarcoma (CS) was the third most common primary bone malignancy. Frequently chondrosarcoma was occurring in long bones or in the pelvis. Their localization in the rib is rare. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393690PMC
February 2019
1 Read

Meta-analysis of ultrasound for cervical lymph nodes in papillary thyroid cancer: Diagnosis of central and lateral compartment nodal metastases.

Eur J Radiol 2019 Mar 7;112:14-21. Epub 2019 Jan 7.

Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Purpose: To evaluate the performance of preoperative ultrasound in the diagnosis of cervical lymph nodes metastases (CLNM) of papillary thyroid cancer (PTC) and its value in assisting cervical lymph node dissection (CLND).

Methods: PubMed, EMBASE and Cochrane Library databases were searched to identify relevant studies up to Sep. 2017. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.01.006DOI Listing

Breast hemangioma in a male patient: Report of a case.

Radiol Case Rep 2019 Apr 16;14(4):427-429. Epub 2019 Jan 16.

General Radiologist at CediMed and Hospital Pablo Tobón Uribe, Radiology Professor at Universidad CES and Universidad Pontificia Bolivariana, Medellín, Colombia.

Breast hemangioma is a rare benign tumor in female and extremely rare in males. They are part of vascular tumors. Here, we described the case of a male patient who had a breast hemangioma for 30 years that was diagnosed incidentally in a thorax and abdomen tomography. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348300PMC

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r = 0. Read More

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019
13 Reads
10.742 Impact Factor

18F-FDG PET/CT versus conventional investigations for cancer screening in autoimmune inflammatory myopathy in the era of novel myopathy classifications.

Nucl Med Commun 2019 Apr;40(4):377-382

Nuclear Medicine Department, Lady Davis Institute, Jewish General Hospital.

Background: To compare the performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) and conventional tests for cancer screening in autoimmune inflammatory myopathy (AIM) patients.

Patients And Methods: We carried out a retrospective cohort study of AIM patients from one academic center in Montreal, Canada, classified using myositis-specific antibodies, who underwent F-FDG PET/CT between April 2005 and February 2018 and were followed up on average 3.5±2. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000981DOI Listing
April 2019
7 Reads

Are BRCA1 and BRCA2 gene mutation patients underscreened for pancreatic adenocarcinoma?

J Surg Oncol 2019 May 12;119(6):777-783. Epub 2019 Jan 12.

Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.

Background: Breast cancer (BRCA) mutations account for the highest proportion of hereditary causes of pancreatic ductal adenocarcinoma (PDAC). Screening is currently recommended only for patients with one first-degree relative or two family members with PDAC. We hypothesized that screening all BRCA1/2 patients would identify a higher rate of pancreatic abnormalities. Read More

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http://dx.doi.org/10.1002/jso.25376DOI Listing
May 2019
3 Reads

Non-Local Based Denoising Framework for In Vivo Contrast-Free Ultrasound Microvessel Imaging.

Sensors (Basel) 2019 Jan 10;19(2). Epub 2019 Jan 10.

Department of Radiology, Mayo Clinic College of Medicine & Science, Rochester, MN 55905, USA.

Vascular networks can provide invaluable information about tumor angiogenesis. Ultrafast Doppler imaging enables ultrasound to image microvessels by applying tissue clutter filtering methods on the spatio-temporal data obtained from plane-wave imaging. However, the resultant vessel images suffer from background noise that degrades image quality and restricts vessel visibilities. Read More

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http://www.mdpi.com/1424-8220/19/2/245
Publisher Site
http://dx.doi.org/10.3390/s19020245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358982PMC
January 2019
8 Reads

Patterns of bone metastases in newly diagnosed colorectal cancer: a real-world analysis in the SEER database.

Int J Colorectal Dis 2019 Mar 8;34(3):533-543. Epub 2019 Jan 8.

Department of Epidemiology and Biostatistics, First Affiliated Hospital, Army Medical University, 30 Gaotanyan Street Shapingba District, Chongqing, 400038, China.

Purpose: To investigate the incidence and the associated factors for bone metastases (BM) development and prognosis in initial colorectal cancer (CRC) with a large sample using Surveillance, Epidemiology, and End Results (SEER) cohort.

Methods: Primary CRC patients, who were initially diagnosed between 2010 and 2015 in the SEER database, were included to analyze BM incidence and risk factors for BM occurrence. The patients with at least 1-year follow-up were involved to investigate the prognostic factors for BM. Read More

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http://dx.doi.org/10.1007/s00384-018-3213-5DOI Listing
March 2019
4 Reads
2.449 Impact Factor

Two case reports on Mandibular metastases.

Ghana Med J 2018 Sep;52(3):168-172

Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Lagos State University College of Medicine, Lagos State, Nigeria.

Metastatic tumours of the oral cavity are not common. The most common site for bone metastases in the head and neck region is the mandible. Metastatic lesion of the mandible most commonly originate from the lungs in men and breast in women, and these lesions (or tumours) usually are carcinomas rather than sarcomas. Read More

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http://dx.doi.org/10.4314/gmj.v52i3.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303547PMC
September 2018
3 Reads

Myofibroblastoma of the breast.

Malays J Pathol 2018 Dec;40(3):349-353

University Malaya Research Imaging Centre, Department of Biomedical Imaging, Kuala Lumpur, Malaysia.

Introduction: Myofibroblastoma is a rare benign mesenchymal tumour arising from the stromal elements of the breast tissue. Histopathological variants such as classic, cellular, collagenous / fibrous, lipomatous, infiltrative, myxoid and epithelioid have been identified. Most myofibroblastomas are immunoreactive for CD34, actin, CD10 and desmin, usually express oestrogen receptor (ER), progesterone receptor (PR) and variably express androgen receptor (AR). Read More

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December 2018
11 Reads

Study of aggressive carcinomas through orbital metastasis.

Arch Soc Esp Oftalmol 2018 Dec 18. Epub 2018 Dec 18.

Servicio de Oftalmología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, España.

Two clinical cases of orbital metastasis are presented. The first is a 63 year-old male with a recent loss of visual acuity associated with binocular diplopia. Neuroimaging tests revealed a tumour of aggressive features with intraconal extension and bone invasion. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03656691183033
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http://dx.doi.org/10.1016/j.oftal.2018.10.012DOI Listing
December 2018
16 Reads

Splenectomy for breast carcinoma diffusely metastatic to the spleen presenting as severe transfusion-dependent anaemia and thrombocytopaenia.

BMJ Case Rep 2018 Dec 18;11(1). Epub 2018 Dec 18.

Surgical Oncology Service, Hillel Yaffe Medical Center, Hadera, Israel.

We report a 48-year-old woman with metastatic infiltrating lobular carcinoma of the breast. Though her metastatic disease remained stable, she was repeatedly admitted for symptomatic anaemia and treated by red blood cell and platelet transfusions with increasing frequency as time elapsed. Abdominal examination and ultrasound revealed splenomegaly (27 cm span). Read More

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http://dx.doi.org/10.1136/bcr-2017-223453DOI Listing
December 2018
1 Read

Incidental Detection of Plasma Cell Neoplasm on 18F-Choline PET/CT Imaging.

Clin Nucl Med 2019 Feb;44(2):140-141

From the Departments of Nuclear Medicine, and.

F-Fluorocholine is a relatively new, extremely versatile radiotracer for detecting proliferative or mitogenic activity. Its diagnostic potential has been explored in cancers of the prostate, liver, esophagus, breast, brain, and lung, as well as lymphoma, sarcoma, melanoma, and parathyroid adenomas. The authors present a case where fluorocholine PET/CT performed for characterizing a space-occupying lesion in the brain revealed intensely tracer-avid skull lesions with intracranial soft tissue component and multiple other skeletal lesions. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9731
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http://dx.doi.org/10.1097/RLU.0000000000002415DOI Listing
February 2019
12 Reads

Axillary lymph node metastasis as the first manifestation of male occult breast cancer: A Case Report.

Medicine (Baltimore) 2018 Dec;97(50):e13706

Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, Jilin Province, China.

Rational: Occult breast cancer (OBC) is an extremely rare breast cancer and is defined by the presence of axillary metastasis without a primary tumor in the breasts or any abnormality on radiologic examination.

Patient Concerns: This case report presents a 49-year-old man who was diagnosed with male OBC, which first manifested as an axillary lymph node metastasis followed by the emergence of infraclavicular lymph node metastasis. Neither the breast nor other organs had any abnormality. Read More

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http://dx.doi.org/10.1097/MD.0000000000013706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320098PMC
December 2018
1 Read
5.723 Impact Factor

Complete pathological response following neoadjuvant FOLFOX chemotherapy in BRCA2-mutant locally advanced rectal cancer: a case report.

BMC Cancer 2018 Dec 14;18(1):1253. Epub 2018 Dec 14.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Patients with locally advanced rectal cancer (LARC) achieving a pathological complete response (pCR) to neoadjuvant treatment usually have a good prognosis, but only accounted for less than 20%.

Case Presentation: We report a case of a 25-year-old male with LARC treated with neoadjuvant FOLFOX chemotherapy, and experienced a pCR. The next-generation sequencing analysis revealed the presence of breast cancer gene 2 (BRCA2) somatic mutation and an increased somatic mutational load without microsatellite instability (MSI). Read More

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http://dx.doi.org/10.1186/s12885-018-5182-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295047PMC
December 2018
1 Read

Biological Aggressiveness of Subclinical No-Mass Ductal Carcinoma In Situ (DCIS) Can Be Reflected by the Expression Profiles of Epithelial-Mesenchymal Transition Triggers.

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Breast Unit, Department of Surgical Oncology, Lower Silesia Oncology Center, 53-413 Wroclaw, Poland.

Epithelial-mesenchymal transitions (EMTs) have been recently implicated in the process of cancer progression. The aim of this study was to assess how the preoperative expression patterns of EMT biomarkers correlate with the risk of postoperative invasion in ductal carcinoma in situ (DCIS) found on stereotactic breast biopsies. N-cadherin, Snail1, and secreted protein acidic and rich in cysteine (SPARC) immunoreactivity was observed in 8%, 62%, and 38% of tumors, respectively. Read More

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http://dx.doi.org/10.3390/ijms19123941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320898PMC
December 2018
2 Reads

First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist Ga-NODAGA-MJ9.

EJNMMI Res 2018 Dec 12;8(1):108. Epub 2018 Dec 12.

Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland.

Background: Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer positron emission tomography (PET) protocol. Five male patients with biochemical relapse of prostate adenocarcinoma underwent four whole-body time-of-flight PET/CT scans within 2 h after tracer injection. Read More

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http://dx.doi.org/10.1186/s13550-018-0462-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291411PMC
December 2018

Palliative Radiotherapy as a Treatment for Carcinoma Invasion of the Sacrum: An Observational Case Series Study.

Anticancer Res 2018 Dec;38(12):6797-6800

Departments of Radiology, Neurology and Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.

Background/aim: Radiotherapy for carcinoma invasion of the sacrum (CIS) is an alternative treatment to surgery in patients with advanced, inoperable tumors or those not medically eligible for resection of the neoplasm. Herein we present an observational study of patients with imaging-confirmed CIS who were treated non-operatively with radiation.

Patients And Methods: A retrospective chart review of CIS patients treated with palliative radiotherapy (PR) during a 9-year period (2004-2013) was performed. Read More

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http://dx.doi.org/10.21873/anticanres.13051DOI Listing
December 2018
2 Reads

Evaluation of the Usefulness of FDG-PET/CT for Nodal Staging of Breast Cancer.

Anticancer Res 2018 Dec;38(12):6639-6652

Department of Surgery, Tor Vergata University Hospital, Rome, Italy.

Background/aim: Positron emission tomography/computed tomography (PET/CT) with F-fluorodeoxyglucose (18F-FDG) has recently been used to investigate lymph node (LN) metastases and several predictive features in patients with breast cancer (BC). The aim of this study was to assess the value of this non-invasive imaging procedure for axillary staging.

Patients And Methods: Fifty patients with early primary unilateral, locally advanced, or recurrent invasive operable BC were enrolled. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13031DOI Listing
December 2018
17 Reads
1.872 Impact Factor

Incidental 18F-NaF Uptake in Drug-Induced Gynecomastia.

Clin Nucl Med 2019 Apr;44(4):e303-e304

Gynecomastia is not uncommon in men older than 50 years of age and is characterized by glandular proliferation of breast tissue. Non-physiologic gynecomastia is mostly caused by a variety of external medical interventions. Medications that belong to classes of antiandrogens, antipsychotics, or antibiotics alter the levels of estrogen and testosterone and are commonly implicated in patients with gynecomastia. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9733
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http://dx.doi.org/10.1097/RLU.0000000000002401DOI Listing
April 2019
14 Reads

Lymph node resection induces the activation of tumor cells in the lungs.

Cancer Sci 2019 Feb 17;110(2):509-518. Epub 2019 Jan 17.

Laboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan.

Lymph node (LN) dissection is a crucial procedure for cancer staging, diagnosis and treatment, and for predicting patient survival. Activation of lung metastatic lesions after LN dissection has been described for head and neck cancer and breast cancer. Preclinical studies have reported that dissection of a tumor-bearing LN is involved in the activation and rapid growth of latent tumor metastases in distant organs, but it is also important to understand how normal (non-tumor-bearing) LN resection influences secondary cancer formation. Read More

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http://dx.doi.org/10.1111/cas.13898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361607PMC
February 2019
3 Reads

Hemangioma of a Male Breast: Case Report and Review of the Literature.

Am J Case Rep 2018 Nov 30;19:1425-1429. Epub 2018 Nov 30.

Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL, USA.

BACKGROUND Male breast hemangioma is a rare benign neoplasm that is usually excised for definitive diagnosis. CASE REPORT In our case report, we present a male octogenarian with multiple comorbidities who presented with a large palpable mass in his right breast. The diagnostic imaging studies were suggestive of a benign tumor, with a BI-RADS (Breast Imaging Reporting and Data System) score of 3. Read More

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https://www.amjcaserep.com/abstract/index/idArt/911842
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http://dx.doi.org/10.12659/AJCR.911842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287655PMC
November 2018
19 Reads

Single-molecule catalytic hairpin assembly for rapid and direct quantification of circulating miRNA biomarkers.

Anal Chim Acta 2018 Dec 22;1042:109-115. Epub 2018 Aug 22.

Department of Clinical Laboratory, Taihe Hospital, Hubei University of Medicine, 32 Renmin South Road, Shiyan, Hubei Province, 442000, China. Electronic address:

The emergence of circulating miRNAs as potential biomarkers for cancer necessitates reliable approaches to detect miRNAs with high sensitivity and specificity. We disclose a highly sensitive method for rapid and direct quantification of circulating miRNA in serum by combining dynamic DNA circuit and single-molecule fluorescence detection. The product of DNA circuits based amplification is detected by total internal reflection fluorescence microscopy (TIRFM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183100
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http://dx.doi.org/10.1016/j.aca.2018.08.037DOI Listing
December 2018
10 Reads

Fluid signal in the mastoid is a common incidental finding on MRI of the brain.

Authors:
J Gossner

Eur Arch Otorhinolaryngol 2019 Feb 12;276(2):611-612. Epub 2018 Nov 12.

Department of Diagnostic and Interventional Radiology, Evangelisches Krankenhaus Göttingen-Weende, An der Lutter 24, 37074, Göttingen, Germany.

Incidental findings are common on patients undergoing magnetic resonance imaging (MRI) of the brain. Fluid signal in the mastoid can be such an incidental finding on MRI of the brain. In only a small number of patients, this relates to inflammatory disease of the middle ear or mastoid. Read More

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http://link.springer.com/10.1007/s00405-018-5197-8
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http://dx.doi.org/10.1007/s00405-018-5197-8DOI Listing
February 2019
23 Reads

Diastolic dysfunction can precede systolic dysfunction on MUGA in cancer patients receiving trastuzumab-based therapy.

Nucl Med Commun 2019 Jan;40(1):22-29

Department of Nuclear Medicine, The Ottawa Hospital.

Background: Trastuzumab (T) and anthracycline (A)-based chemotherapy is considered the standard of care in human epidermal growth factor receptor-2+ overexpressing breast cancer, but requires monitoring for known cardiotoxicity using left ventricular (LV) ejection fraction (EF) every 3-4 months during treatment. It is not conclusively established whether diastolic dysfunction (DD) precedes LVEF decrease in patients developing trastuzumab-induced cardiotoxicity (TIC).

Objective: The aim was to elucidate whether DD precedes LVEF decrease in trastuzumab-treated patients being monitored with radionuclide multigated acquisition for TIC. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282666PMC
January 2019
14 Reads

ACR Appropriateness Criteria Evaluation of the Symptomatic Male Breast.

J Am Coll Radiol 2018 Nov;15(11S):S313-S320

Panel Chair, Emory University Hospital, Atlanta, Georgia.

Although the majority of male breast problems are benign with gynecomastia as the most common etiology, men with breast symptoms and their referring providers are typically concerned about whether or not it is due to breast cancer. If the differentiation between benign disease and breast cancer cannot be made on the basis of clinical findings, or if the clinical presentation is suspicious, imaging is indicated. The panel recommends the following approach to breast imaging in symptomatic men. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15461440183115
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http://dx.doi.org/10.1016/j.jacr.2018.09.017DOI Listing
November 2018
8 Reads

The Shiraz Breast Cancer Registry (SBCR): study design and primary reports.

Per Med 2018 11 30;15(6):471-479. Epub 2018 Oct 30.

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Aim: This is a description of the largest breast cancer (BC) registry in Iran, termed the Shiraz Breast Cancer Registry (SBCR).

Methods: Data on baseline and clinical characteristics, socioeconomic status, imaging, physical examination, histopathology, treatment and prognosis have been recorded for each individual.

Results: Overall, 5937 were included in the report. Read More

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https://www.futuremedicine.com/doi/10.2217/pme-2018-0047
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http://dx.doi.org/10.2217/pme-2018-0047DOI Listing
November 2018
17 Reads

[Classification of Clinical Syndromes Associated with Skull-Base Metastasis in the MR Era].

No Shinkei Geka 2018 Oct;46(10):865-873

Division of Neurosurgery, Shizuoka Cancer Center.

Background: Skull-base metastases frequently cause progressive ipsilateral disturbances of cranial nerves or pain, resulting in poor quality of life in patients with cancer. Magnetic resonance(MR)imaging is the method to detect skull-base metastases, which demonstrates focal lesions of low-intensity signal and enhancement on T1-weighted MR images.

Methods: We reviewed clinical data and MR images from 127 patients with skull-base metastases diagnosed at Shizuoka Cancer Center Hospital between August 2012 and November 2017. Read More

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http://dx.doi.org/10.11477/mf.1436203829DOI Listing
October 2018
16 Reads

Predictive factors for adrenal metastasis in extra-adrenal malignancy patients with solitary adrenal mass.

J Surg Oncol 2018 Dec 27;118(8):1271-1276. Epub 2018 Oct 27.

Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea.

Background And Objectives: The adrenal gland is a frequent site for metastasis, and a solitary adrenal mass is often observed during staging workup or imaging follow-up in patients with extra-adrenal malignancy. To create an appropriate management plan, it is essential to distinguish between benign adrenal lesions and metastasis in patients with extra-adrenal cancer having solitary adrenal masses. Therefore, here we evaluated the predictive factors for adrenal metastasis in patients with extra-adrenal malignancy having solitary adrenal mass. Read More

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http://doi.wiley.com/10.1002/jso.25272
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http://dx.doi.org/10.1002/jso.25272DOI Listing
December 2018
19 Reads

Stereotactic Body Radiotherapy for Spinal Metastases: Clinical Experience in 134 Cases From a Single Japanese Institution.

Technol Cancer Res Treat 2018 01;17:1533033818806472

1 Division of Radiation Oncology, Department of Radiology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Bunkyo-ku, Tokyo, Japan.

Object: This study aimed to clarify the outcomes of stereotactic body radiotherapy for spinal metastases with a uniform dose fractionation schedule in our institution.

Materials And Methods: Patients treated with spine stereotactic body radiotherapy were retrospectively reviewed. The prescribed dose was 24 Gy in 2 fractions. Read More

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http://dx.doi.org/10.1177/1533033818806472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202742PMC
January 2018
4 Reads

Aberrant cystatin-C expression in blood from patients with breast cancer is a suitable marker for monitoring tumor burden.

Oncol Lett 2018 Nov 3;16(5):5583-5590. Epub 2018 Sep 3.

Department of Laboratory Medicine, Inha University College of Medicine, Incheon 22332, Republic of Korea.

The present study was performed to evaluate the efficacy of circulating cystatin-C as a tumor monitoring biomarker at different clinical time points in patients with breast cancer over a long-term follow-up period. In addition, the secretory rate of circulating cystatin-C from cancer tissue was investigated by comparing the blood and tissue expression levels of cystatin-C. Blood samples from healthy volunteers (40 males and 40 females) were obtained at yearly health examinations if laboratory and imaging abnormalities were not detected. Read More

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http://dx.doi.org/10.3892/ol.2018.9380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176264PMC
November 2018

An Assessment of Novel Biomarkers in Bone Metastatic Disease Using Multiplex Measurement and Multivariate Analysis.

Technol Cancer Res Treat 2018 01;17:1533033818807466

1 Department of Immunochemistry, University Hospital and Faculty of Medicine in Pilsen, Charles University, Plzen, Czech Republic.

Aim: Current diagnostics of bone metastatic disease is not satisfactory for early detection or regular process monitoring. The combination of biomarkers and the multiparametric approach was described as effective in other oncology diagnoses. The aim of the study was to improve the difference diagnostics between bone-metastatic disease and solid tumors using mutivariate logistic regression model. Read More

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http://dx.doi.org/10.1177/1533033818807466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198393PMC
January 2018
2 Reads

Initial experience with dual-energy computed tomography-guided bone biopsies of bone lesions that are occult on monoenergetic CT.

Skeletal Radiol 2019 Apr 20;48(4):605-613. Epub 2018 Oct 20.

Department of Radiology, Northwestern University Feinberg School of Medicine, 676 North Saint Clair Street, Suite 800, Chicago, IL, 60611, USA.

Objective: Our purpose was to determine whether dual-energy CT (DECT), specifically the bone marrow setting of the virtual noncalcium (VNCa) algorithm, could be used to identify and accurately biopsy suspected bone malignancies that were visible on magnetic resonance imaging (MRI), nuclear bone scintigraphy, or positron-emission tomography/computed tomography (PET/CT), but occult on monoenergetic computed tomography (CT) by virtue of being either isodense or nearly isodense to surrounding normal bone.

Materials And Methods: We present 4 cases in which DECT was used to detect various malignant bone lesions and was successfully used to direct percutaneous DECT-guided bone biopsies.

Results: Two of the lesions were solid tumor metastases (breast and prostate carcinoma), whereas two others were hematological malignancies (leukemia and lymphoma). Read More

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http://link.springer.com/10.1007/s00256-018-3087-1
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http://dx.doi.org/10.1007/s00256-018-3087-1DOI Listing
April 2019
9 Reads

An Interesting Case of Hepatic Adrenocortical Carcinoma.

Acta Med Indones 2018 Jul;50(3):257-259

Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran - Hasan Sadikin Hospital, Bandung, Indonesia.

Adrenocortical carcinoma (ACC) is a rare solid tumor with an incidence of 0.5 to 2 cases per million per year. It affects women more commonly than men with a ratio of 1. Read More

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July 2018
13 Reads

Diffusional kurtosis imaging in head and neck cancer: On the use of trace-weighted images to estimate indices of non-Gaussian water diffusion.

Med Phys 2018 Dec 8;45(12):5411-5419. Epub 2018 Nov 8.

Unit of Medical Physics, Pisa University Hospital "Azienda Ospedaliero-Universitaria Pisana", 56126, Pisa, Italy.

Purpose: While previous studies have demonstrated the feasibility and potential usefulness of quantitative non-Gaussian diffusional kurtosis imaging (DKI) of the brain, more recent research has focused on oncological application of DKI in various body regions such as prostate, breast, and head and neck (HN). Given the need to minimize scan time during most routine magnetic resonance imaging (MRI) acquisitions of body regions, diffusion-weighted imaging (DWI) with only three orthogonal diffusion weighting directions (x, y, z) is usually performed. Moreover, as water diffusion within malignant tumors is generically thought to be almost isotropic, DWI with only three diffusion weighting directions is considered sufficient for oncological application and it represents the de facto standard in body DKI. Read More

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http://doi.wiley.com/10.1002/mp.13238
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http://dx.doi.org/10.1002/mp.13238DOI Listing
December 2018
10 Reads

Diagnostic and prognostic value of 18F-FDG PET/CT imaging in suspected recurrence of male breast cancer.

Nucl Med Commun 2019 Jan;40(1):63-72

Radiotherapy, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: Male breast cancer (MBC) is a rare malignancy, with recurrence being one of the main adverse predictors for prognosis. The aim of the study was to evaluate the diagnostic and predictive value of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in the setting of suspected recurrence of MBC.

Patients And Methods: Retrospective analysis of PET/CT findings was performed in 23 previously treated, histologically proven patients with MBC (mean age: 59. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282661PMC
January 2019
28 Reads

A clinical 3D/4D CBCT-based treatment dose monitoring system.

J Appl Clin Med Phys 2018 Nov 10;19(6):166-176. Epub 2018 Oct 10.

Department of Radiation Oncology, Beaumont Health System, Royal Oak, MI, USA.

To monitor delivered dose and trigger plan adaptation when deviation becomes unacceptable, a clinical treatment dose (Tx-Dose) reconstruction system based on three-dimensional (3D)/four-dimensional (4D)-cone beam computed tomograpy (CBCT) images was developed and evaluated on various treatment sites, particularly for lung cancer patient treated by stereotactic body radiation therapy (SBRT). This system integrates with our treatment planning system (TPS), Linacs recording and verification system (R&V), and CBCT imaging system, consisting of three modules: Treatment Schedule Monitoring module (TSM), pseudo-CT Generating module (PCG), and Treatment Dose Reconstruction/evaluation module (TDR). TSM watches the treatment progress in the R&V system and triggers the PCG module when new CBCT is available. Read More

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http://doi.wiley.com/10.1002/acm2.12474
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http://dx.doi.org/10.1002/acm2.12474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236849PMC
November 2018
3 Reads

[Extramedullary Plasmacytoma].

Rofo 2018 Nov 8;190(11):1006-1009. Epub 2018 Oct 8.

Diagnostic and Interventional Radiology, Universität Leipzig Medizinische Fakultät, Leipzig, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0604-2831
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http://dx.doi.org/10.1055/a-0604-2831DOI Listing
November 2018
4 Reads

99mTc-MIBI single photon emission computed tomography/computed tomography for the incidental detection of rare parathyroid carcinoma.

Medicine (Baltimore) 2018 Oct;97(40):e12578

Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing.

This study aimed to evaluate the characteristics of parathyroid carcinoma and to validate the diagnostic value of Tc-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography/x-ray computed tomography (SPECT/CT) for differentiating between parathyroid carcinoma and hyperparathyroidism. Four consecutive patients with suspected primary hyperparathyroidism were enrolled in this study and underwent Tc-MIBI SPECT/CT, ultrasonography, enhanced CT, and MRI. Serum parathyroid hormone (PTH) and calcium were measured. Read More

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http://dx.doi.org/10.1097/MD.0000000000012578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200521PMC
October 2018
5 Reads

F-FDG-PET/CT features of primary tumours for predicting the risk of recurrence in thyroid cancer after total thyroidectomy: potential usefulness of combination of the SUV-related, volumetric, and heterogeneous texture parameters.

Br J Radiol 2019 Feb 7;92(1094):20180620. Epub 2018 Nov 7.

1 Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka , Kagoshima , Japan.

Objective:: This retrospective study examined whether the primary tumour 18F-FDG uptake features could predict the high-risk of recurrence in differentiated thyroid cancer (DTC) patients.

Methods:: The enrolled 114 DTC patients underwent preoperative F-FDG-PET/CT. SUVmax, SUVmean, metabolic tumour volume (MTV), total lesion glycolysis (TLG) and 6 texture parameters were obtained. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180620
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http://dx.doi.org/10.1259/bjr.20180620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404810PMC
February 2019
1 Read

Clinical translation of [F]ICMT-11 for measuring chemotherapy-induced caspase 3/7 activation in breast and lung cancer.

Eur J Nucl Med Mol Imaging 2018 12 27;45(13):2285-2299. Epub 2018 Sep 27.

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W120NN, UK.

Background: Effective anticancer therapy is thought to involve induction of tumour cell death through apoptosis and/or necrosis. [F]ICMT-11, an isatin sulfonamide caspase-3/7-specific radiotracer, has been developed for PET imaging and shown to have favourable dosimetry, safety, and biodistribution. We report the translation of [F]ICMT-11 PET to measure chemotherapy-induced caspase-3/7 activation in breast and lung cancer patients receiving first-line therapy. Read More

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http://dx.doi.org/10.1007/s00259-018-4098-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208806PMC
December 2018
3 Reads

Knowledge and Awareness of Colorectal Cancer among General Public of Kuwait

Asian Pac J Cancer Prev 2018 Sep 26;19(9):2455-2460. Epub 2018 Sep 26.

Department of Radiological Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait. Email:

Colorectal cancer (CRC) is the third most common type of cancer and also the fourth most common cause of cancer related death in both men and women worldwide. The CRC is considered to be the second killer in Kuwait after breast cancer. Aim: to assess and identify the level of knowledge and awareness of colorectal cancer with regards to risk factors, symptoms and screening/imaging procedures among general public in the State of Kuwait. Read More

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http://journal.waocp.org/article_69113.html
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http://dx.doi.org/10.22034/APJCP.2018.19.9.2455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249459PMC
September 2018
22 Reads

Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage.

PLoS One 2018 24;13(9):e0198464. Epub 2018 Sep 24.

Department of Pathology, UC San Diego, La Jolla, CA, United States of America.

Matrix metalloproteinases-2 and -9 (MMP-2/-9) are key tissue remodeling enzymes that have multiple overlapping activities critical for wound healing and tumor progression in vivo. To overcome issues of redundancy in studying their functions in vivo, we created MMP-2/-9 double knockout (DKO) mice in the C57BL/6 background to examine wound healing. We then bred the DKO mice into the polyomavirus middle T (PyVmT) model of breast cancer to analyze the role of these enzymes in tumorigenesis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198464PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152858PMC
February 2019
7 Reads

The feasibility of using 18F-FDG-PET/CT in patients with mucinous breast carcinoma.

Nucl Med Commun 2018 Nov;39(11):1033-1038

Surgery, Breast Surgery, Tokyo Medical and Dental University, Tokyo, Japan.

Purpose: This study investigated the correlation between fluorine-18-fluorodeoxyglucose (F-FDG)-PET/computed tomography (CT) and clinicopathological factors in patients with mucinous breast carcinoma and assessed the feasibility of using F-FDG-PET/CT in evaluating tumors.

Patients And Methods: We retrospectively examined 42 consecutive patients with pathologically proven mucinous breast carcinoma who preoperatively underwent F-FDG-PET/CT. In addition, we compared F-FDG uptake with clinicopathological characteristics. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000910DOI Listing
November 2018
1 Read