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Eur J Surg Oncol 2022 Jun 10. Epub 2022 Jun 10.

University Hospital Wishaw, United Kingdom.

Background: Although male breast cancer (MBC) is a rare disease, accounting for <1% of all breast cancers, it has significant oncological, survival and psychosocial implications for patients. The aim of this study is to assess the latest literature in the diagnosis, management, oncological outcomes, and psychosocial impact of MBC.

Methods: A systematic literature review was conducted using the PRISMA guidelines (Moher et al. Read More

Zhonghua Yi Xue Za Zhi 2022 Jun;102(23):1753-1759

Department of Radiology, Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China.

To develop a model combined with dual-energy CT quantitative parameters and conventional CT features for evaluating the expression level of Ki-67 in invasive breast cancer. A total of 191 patients with histologically confirmed invasive breast cancer in Lishui Central Hospital from March 2019 to December 2020, were retrospectively enrolled, all of them were females, aged from 25 to 77 (53.2±11. Read More

Cureus 2022 May 8;14(5):e24834. Epub 2022 May 8.

Tocogynecology, Oncocenter, Teresina, BRA.

Lung cancer is the second most common malignancy worldwide, accounting for the highest number of cancer deaths. Advanced lung cancer may infrequently appear as skin metastasis and this may be the first sign of the disease. In these cases, survival is low and prognosis is poor. Read More

Contrast Media Mol Imaging 2022 26;2022:5847589. Epub 2022 May 26.

Department of Spinal Surgery, Dongying Shengli Oilfield Central Hospital, Dongying City 257100, Shandong Province, China.

Objective: To explore the diagnostic value of emission computed tomography (ECT) combined with computed tomography (CT) for metastatic malignant tumor of spine.

Methods: By means of retrospective study, a total of 102 patients with extraskeletal primary malignant tumor treated in our hospital from February 2019 to February 2021 were selected as the subjects. All patients had single lesion of the spine, of which 72 were malignant and 30 were benign according to the results of pathological examination. Read More

Int J Environ Res Public Health 2022 06 4;19(11). Epub 2022 Jun 4.

Faculty of Science and Technology, University of Silesia, 75 Pułku Piechoty Street 1A, 41-500 Chorzów, Poland.

The aim of the study was to use thermal imaging to evaluate long-term chest temperature changes in patients who had previously been treated with radiotherapy. The examination with a thermal imaging camera involved 144 women-48 of them were patients after RT, 48 were females before breast cancer radiotherapy and the last group of participants were 48 healthy women. All patients (before and after radiotherapy) were divided into women after mastectomy and those after conservative surgery. Read More

Nuklearmedizin 2022 Jun 3;61(3):247-261. Epub 2022 Jun 3.

Department of Nuclear Medicine, Rostock University Medical Center, Rostock, Germany.

Addressing molecular targets, that are overexpressed by various tumor entities, using radiolabeled molecules for a combined diagnostic and therapeutic (theranostic) approach is of increasing interest in oncology. The gastrin-releasing peptide receptor (GRPr), which is part of the bombesin family, has shown to be overexpressed in a variety of tumors, therefore, serving as a promising target for those theranostic applications. A large amount of differently radiolabeled bombesin derivatives addressing the GRPr have been evaluated in the preclinical as well as clinical setting showing fast blood clearance and urinary excretion with selective GRPr-binding. Read More

J Surg Res 2022 May 25;278:223-232. Epub 2022 May 25.

The Department of General Surgery, Istanbul Medeniyet University, Goztepe Prof. Dr Suleyman Yalcin City Hospital, Istanbul, Turkey.

Introduction: The present study aims to determine the diagnostic accuracy of magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT) in predicting a pathological response of molecular subtypes of breast cancer to neoadjuvant chemotherapy (NAC).

Materials And Methods: We retrospectively analyzed patients with breast cancer who were operated after NAC between January 2018 and May 2020. Radiological responses were evaluated as per the Response Evaluation Criteria in Solid Tumors (RECIST) and changes in contrast enhancement patterns on MRI and the classification of PET Response Criteria in Solid Tumors (PERCIST) on PET-CT. Read More

Dis Markers 2022 19;2022:7739777. Epub 2022 May 19.

Department of General Surgery, Xuanwu Hospital, Capital Medical University, China.

Objective: Serum tumor marker (STM) elevation can detect metastasis earlier than imaging diagnosis and, although not recommended by guidelines, is still widely used in clinical practice for postoperative follow-up of breast cancer patients. The purpose of this study was to investigate the change rules of CEA and CA153 in patients with HER2-negative breast cancer during postoperative adjuvant chemotherapy and their influencing factors.

Materials And Methods: The medical records of patients with HER2-negative early breast cancer who visited Xuanwu Hospital from September 2018 to June 2021 were retrospectively analyzed. Read More

Drug Des Devel Ther 2022 18;16:1515-1530. Epub 2022 May 18.

Ultrasound Department, Shengjing Hospital, China Medical University, Shenyang, People's Republic of China.

Objective: Gastric cancer is one of the most lethal malignancies in the world. However, the current research on the diagnosis and treatment of nano-ultrasound contrast agents in the field of tumor is mostly focused on breast cancer, ovarian cancer, prostate cancer, liver cancer, etc. Due to the interference of gas in the stomach, there is no report on the treatment of gastric cancer. Read More

Cureus 2022 Apr 17;14(4):e24216. Epub 2022 Apr 17.

Oncology, AMITA Health Saint Francis Hospital, Evanston, USA.

Cardiac metastatic disease is a rare finding and is usually diagnosed incidentally postmortem; it has been commonly reported in patients with cancers of lung, esophagus, breast, and melanoma. We present a case of a 62-year-old male with a history of squamous cell carcinoma of the pyriform sinus who presented with shortness of breath for one day. He underwent tumor resection followed by chemotherapy and radiotherapy seven months before this presentation. Read More

Ann Ital Chir 2022 Feb 25;11. Epub 2022 Feb 25.

Aim: Angiolipoma is uncommon lesion in the breast and has clinical importance due to the potential of confusion with malignant breast lesions. To date, there is no defined diagnosis and treatment algorithm for breast angiolipomas. We aim to contribute to the literature for the diagnosis and treatment of angiolipomas with this case report and literature review. Read More

Sci Rep 2022 May 18;12(1):8317. Epub 2022 May 18.

University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

The aim of this study was to detect a response difference in primary (PLC) and secondary liver tumors (SLC) with magnetic resonance elastography (MRE) after TACE therapy. Thirty-one patients (25/31 male; mean age 69.6 years [range: 39-85 years]) with repeated TACE therapy of HCC were compared with twenty-seven patients (27/27 female; mean age 61. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Feb;47(2):238-243

Department of Radiology, First Hospital of Changsha, Changsha 410005, China.

Objectives: Accurate breast lesion surface localization can guarantee accurate biopsy and local treatment. But there is no guideline to regular equipment and methods for the localization of breast lesions. The conventional non-invasive localization method is marker-based localization. Read More

JAMA Netw Open 2022 May 2;5(5):e2210331. Epub 2022 May 2.

Department of Radiology, University of Michigan, Ann Arbor.

Importance: Guiding treatment decisions for women with ductal carcinoma in situ (DCIS) requires understanding patient preferences and the influence of preoperative magnetic resonance imaging (MRI) and surgeon recommendation.

Objective: To identify factors associated with surgery preference and surgery receipt among a prospective cohort of women with newly diagnosed DCIS.

Design, Setting, And Participants: A prospective cohort study was conducted at 75 participating institutions, including community practices and academic centers, across the US between March 25, 2015, and April 27, 2016. Read More

N C Med J 2022 May-Jun;83(3):221-228

Director, High-Risk Clinic, The Outer Banks Hospital, Nags Head, North Carolina; medical director, The Breast Center, Chesapeake Regional Medical Center, Chesapeake, Virginia.

The average lifetime risk of breast cancer for an American woman is 12.5%, but individual risks vary significantly. Risk modeling is a standard of care for breast cancer screening and prevention with recommended tools to stratify individual risks based on age, family history, breast density, and a host of other known risk factors. Read More

Radiother Oncol 2022 07 30;172:65-75. Epub 2022 Apr 30.

Cancer Research Institute, University of South Australia, Adelaide, Australia; Department of Physics, University of Adelaide, Australia.

Background And Purpose: Proton therapy (PT) can reduce side effects for paediatric cranial malignancies. Despite the high number of paediatric patients treated with PT, radiation induced risk factors for second primary cancer (SPC) in out-of-field organs are unknown. This study estimated lifetime attributable risk (LAR) of SPC as a function of age and sex for out-of-field organs following passive scattering and scanning beam PT in paediatric brain tumours. Read More

Strahlenther Onkol 2022 Jul 2;198(7):612-621. Epub 2022 May 2.

Department of Radiation Oncology, SS. Annunziata Hospital, "G. D'Annunzio" University of Chieti, Via dei Vestini, 66100, Chieti, Italy.

Purpose: Axillary management remains unclear when sentinel lymph node (SLN) results are positive in cN0 patients with breast cancer (BC). The trial ACOSOG Z0011 represented a revolution with axillary lymph node dissection (ALND) omission in SLN+ patients, despite critiques regarding non-uniformity of radiation fields. We conducted an observational study (LISEN) where whole breast radiotherapy (WBRT) was planned with tangential fields without nodal irradiation in patients eligible for the Z0011 trial. Read More

Rev Sci Instrum 2022 Apr;93(4):044101

Genetic Epidemiology Group, School of Population and Global Health, The University of Western Australia, 35 Stirling Highway M431, Crawley, Western Australia 6009, Australia.

Mammographic breast density is a strong breast cancer risk factor, and its routine clinical measurement could potentially be used to identify women at higher risk of breast cancer and/or monitor primary prevention strategies. Previous reports of optical breast spectroscopy (OBS), a novel approach to measuring breast density, demonstrated that it is safe (no ionizing radiation), portable, low-cost, and does not require image interpretation but have been limited to small, single-center studies. Reference measurements taken on a phantom breast prior to and after each woman's OBS assessment are required for the calibration of the system transfer function as a part of processing participant data. Read More

BMJ Open 2022 04 29;12(4):e050457. Epub 2022 Apr 29.

Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Objectives: This mixed-method study aimed to understand the effectiveness of linkage to biopsy and treatment in women with a high-risk mammography result (Breast Imaging Reporting and Data System, BI-RADS 4 and 5) in the national telemammography programme and to explore women's experiences during this process.

Setting: Quantitative component: we collected and linked health data from the telemammography reading centre, the national public health insurance, the national centre for disease control and the national referral cancer centre. Qualitative component: we interviewed participants from different regions of the country representing diverse social and geographical backgrounds. Read More

Am Surg 2022 Jul 24;88(7):1588-1589. Epub 2022 Apr 24.

Division Chief, Surgical Oncology, Department of Surgery, School of Medicine, 21693University of Mississippi Medical Center, Jackson, MS, USA.

Sweat gland carcinomas are a rare group of cancer, representing less than .01% of all diagnosed skin malignancies. We report the case of a 32-year-old male who presented with a fungating lesion on the posterolateral side of his left knee. Read More

Eur J Radiol 2022 Jun 18;151:110320. Epub 2022 Apr 18.

Department of Radiology, Paracelsus Medical University, Salzburg, Austria; Department of Health Sciences and Medicine, Universität Luzern, Frohburgstrasse 3, 6002 Luzern, Switzerland; Institute of Radiology and Nuclear Medicine and Breast Center St. Anna, Hirslanden Klinik St. Anna, St. Anna-Strasse 32, 6006 Lucerne, Switzerland.

Background & Aims: To determine if radiological hard- and software offers options beyond the binary female / male classification.

Methods: We surveyed thirteen radiological hardware and six radiological software vendors about the options to enter patient gender.

Results: Six of thirteen hardware and five of six software vendors replied to our inquiry. Read More

J Healthc Eng 2022 12;2022:4834594. Epub 2022 Apr 12.

Radiology Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan City 250011, Shandong Province, China.

Objective: To compare the application value of dynamic enhanced magnetic resonance imaging (MRI) and ultrasonic diffused optical tomography (DOT) in early diagnosis of breast cancer.

Methods: The clinical data of 110 female patients with breast diseases treated in our hospital from June 2018 to June 2021 were selected for the retrospective analysis, and the patients were divided into the benign lesion group ( = 50) and breast cancer group ( = 60) according to the pathologic findings. All patients received dynamic enhanced MRI and ultrasonic DOT examinations for the observation of lesion morphology and analysis of relevant parameters, so as to scientifically evaluate the diagnostic value of dynamic enhanced MRI and ultrasonic DOT for early breast cancer. Read More

Eur J Breast Health 2022 Apr 1;18(2):199-202. Epub 2022 Apr 1.

Department of Radiology, Trakya University Faculty of Medicine, Edirne, Turkey.

Breast cancer is a rare entity in men, accounting for less than 1% of all breast cancers. Contralateral breast cancer diagnosed within 12 months of the prior breast cancer is known as bilateral synchronous breast cancer. Bilateral, synchronous male breast cancer is extremely rare and consequently there are few publications describing imaging findings of synchronous bilateral male breast cancer. Read More

Comput Math Methods Med 2022 8;2022:6841334. Epub 2022 Apr 8.

Department of Information Technology, Dambi Dollo University, Dembi Dolo, Welega, Ethiopia.

Breast cancer is the second leading cause of death among women, behind only heart disease. However, despite the high incidence and mortality rates associated with breast cancer, it is still unclear as to what is responsible for its development in the first place. The prevention of breast cancer is not possible with any of the current available methods. Read More

Front Immunol 2022 30;13:850240. Epub 2022 Mar 30.

Department of Oncology, Linköping University, Linköping, Sweden.

High mammographic density and exposure to sex steroids are independent risk factors for breast cancer by yet unknown mechanisms. Inflammation is one hallmark of cancer and the tumor necrosis factor family of proteins (TNFSFs) and receptors (TNFRSFs) are key determinants of tissue inflammation. The relationship between TNFSFs/TNFRSFs and breast tissue density or local breast estradiol levels is unknown. Read More

Radiologia (Engl Ed) 2022 Mar;64 Suppl 1:37-43

Departamento de Imágenes, Facultad de Medicina Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.

Adenomyoepithelioma of the breast (AB) is an uncommon tumor that is characterized by the biphasic proliferation of epithelial and myoepithelial cells. The radiologic findings for AB have been scantly reported. This paper aims to analyze the characteristic findings for AB on ultrasonography (US) and mammography. Read More

Lancet Oncol 2022 05 12;23(5):601-611. Epub 2022 Apr 12.

Institute of Biostatistics and Clinical Research, University of Münster and University Hospital Münster, Münster, Germany.

Background: Two dimensional (2D) full-field digital mammography is the current standard of breast cancer screening. Digital breast tomosynthesis generates pseudo-three dimensional datasets of the breast from which synthesised 2D (s2D) mammograms can be reconstructed. This innovative approach reduces the likelihood of overlapping breast tissues that can conceal features of malignancy. Read More

JAMA Netw Open 2022 04 1;5(4):e227234. Epub 2022 Apr 1.

Harvard Medical School, Boston, Massachusetts.

Importance: Increasing use of screening breast magnetic resonance imaging (MRI), including among women at low or average risk of breast cancer, raises concerns about resulting mammary and extramammary cascades (downstream services and new diagnoses) of uncertain value.

Objective: To estimate rates of cascade events (ie, laboratory tests, imaging tests, procedures, visits, hospitalizations, and new diagnoses) and associated spending following screening breast MRI vs mammography among commercially insured US women.

Design, Setting, And Participants: This cohort study used 2016 to 2018 data from the MarketScan research database (IBM Corporation), which includes claims and administrative data from large US employers and commercial payers. Read More

Ann Med Surg (Lond) 2022 Mar 1;75:103421. Epub 2022 Mar 1.

Neurosurgery department, University Hospital Center IBN ROCHD, Casablanca, Morocco.

Male breast cancer is rare, less than 1% of men's cancers. The tumors occurring in the cerebellopontine angle remain a rare entity. Features suggestive of metastasis are acute onset, rapid progression of symptoms. Read More

Radiology 2022 Jul 5;304(1):218-224. Epub 2022 Apr 5.

From the Departments of Radiology (S.J., C.U.L., G.K.H., J.M.K.), Pharmacy (N.J.B.), and Plastic Surgery (N.V.T.), Mayo Clinic, 200 First St SW, Rochester, MN 55905.

Background Lymphaticovenous anastomosis (LVA) surgery is an effective surgical treatment of secondary lymphedema in the extremities, but indocyanine green (ICG) fluorescent lymphography, the reference standard for imaging target lymphatic vessels, has several limitations. More effective methods are needed for preoperative planning. Purpose To evaluate whether contrast-enhanced US (CEUS) can be used to identify target lymphatic vessels for LVA surgery in patients with secondary upper extremity lymphedema and compare the results with those from ICG fluorescent lymphography. Read More