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Cureus 2020 May 25;12(5):e8277. Epub 2020 May 25.

Radiology, University of Texas Medical Branch, Galveston, USA.

Due to the lower rate of breast cancer in men compared to women, there are fewer studies on which to base the treatment of a male patient with breast cancer; and this is further complicated when the patient is part of the elderly population. We report the case of an 81-year-old male who came in for imaging of pulmonary nodules and had an incidental finding of abnormal growth in the breast. Further imaging was performed, and biopsy was completed, confirming invasive ductal carcinoma. Read More

Dig Dis Sci 2020 Jun 27. Epub 2020 Jun 27.

Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.

Background: Immune checkpoint inhibitors (ICI) have improved outcomes in patients with various malignancies; however, they can cause immune-related hepatitis and enterocolitis. Patients on ICI may also develop upper gastrointestinal symptoms and undergo measurement of gastric emptying.

Aims: Our aim was to review records of patients with gastroparesis following ICI therapy at two medical centers. Read More

Clin Imaging 2020 Jun 17;68:45-56. Epub 2020 Jun 17.

Grupo Fleury, São Paulo, Brazil; Hospital São Paulo, Universidade Federal de São Paulo, São Paulo, Brazil.

The male breast is affected by a broad spectrum of conditions, ranging from benign to malignant, many of which are similar to those occurring in its female counterpart. Despite the challenge motivated by different imaging characteristic features, correct imaging interpretation in male breast disease may aid at differentiation between benign and suspected conditions, narrow the differential diagnosis and guide subsequent management. The purpose of this review is to showcase a wide array of male breast diseases, discuss their imaging presentations and key features for diagnosis. Read More

Am J Cancer Res 2020 1;10(5):1477-1517. Epub 2020 May 1.

KU Leuven, Campus Gasthuisberg, Faculty of Medicine Leuven 3000, Belgium.

Metastasis is a major cause of cancer-related death and liver metastasis (LM) is a distinct type for its relatively good prognosis after timely treatment for selected patients. However, a generalizable estimation of incidence and prognosis of LM is lacking. Cancer patients with known LM status in the Surveillance, Epidemiology and End Results database were enrolled in the present study. Read More

In Vivo 2020 Jun;34(3 Suppl):1685-1694

Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy.

Background/aim: Despite the large amount of clinical data available of Coronavirus-19 (COVID-19), not many studies have been conducted about the psychological toll on Health Care Workers (HCWs).

Patients And Methods: In this multicentric descriptive study, surveys were distributed among 4 different Breast Cancer Centers (BCC). BCCs were distinguished according to COVID-19 tertiary care hospital (COVID/No-COVID) and district prevalence (DP) (High vs. Read More

J Am Coll Radiol 2020 May 28. Epub 2020 May 28.

Department of Radiology, Texas A&M University Health Sciences, Temple, Texas. Electronic address:

Breast cancer is the most common nonskin cancer in women and the second leading cause of cancer death for women in the United States. Mammography screening is proven to significantly decrease breast cancer mortality, with a 40% or more reduction expected with annual use starting at age 40 for women of average risk. However, less than half of all eligible women have a mammogram annually. Read More

Radiol Case Rep 2020 Jul 7;15(7):970-974. Epub 2020 May 7.

Department of Pathology, Anatomy, and Laboratory Medicine, West Virginia University, Morgantown, WV, USA.

Renal cell cancer (RCC) is among the 10 most common cancers affecting both genders in the United States. Advanced RCC often remains clinically silent for much of its natural history. This can make the diagnosis challenging, especially when presenting symptoms arise from a metastasis. Read More

Mol Imaging Radionucl Ther 2020 Apr;29(2):82-84

Gazi University, Department of Nuclear Medicine, Ankara, Turkey.

Prostate cancer is a common neoplastic disease especially in elder patients. Metastatic prostate disease has low five-year survival rate. Bicalutamide is an androgen receptor antagonist that acts as an inhibitor by competizing androgen receptors in the target tissue and used as a treatment option in prostate cancer. Read More

Molecules 2020 Apr 26;25(9). Epub 2020 Apr 26.

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, 04318 Leipzig, Germany.

Overexpression of monocarboxylate transporters (MCTs) has been shown for a variety of human cancers (e.g., colon, brain, breast, and kidney) and inhibition resulted in intracellular lactate accumulation, acidosis, and cell death. Read More

Radiol Case Rep 2020 Jun 21;15(6):799-802. Epub 2020 Apr 21.

Ameripath Lubbock Pathology, Ameripath, Lubbock, TX 79407, USA.

Metastatic disease of the lung has been extensively documented in the adult patient population. The most common primary sources for pulmonary metastases include breast, colon gastrointestinal including pancreas and urinary bladder. Malignant lung tumors in pediatric population is extremely rare. Read More

Radiol Case Rep 2020 Jun 8;15(6):727-729. Epub 2020 Apr 8.

Department of Radiology, Massachusetts General Hospital, 55 Fruit St Boston, MA 02114-2696, USA.

Invasive lobular carcinoma (ILC) in the male breast is a rare subtype of a rare disease in men, accounting for approximately 1%-2% of all male breast cancers [1,2]. Only a few cases have been reported in the literature. The pathophysiology is uncommon due to a paucity of lobular development seen in men. Read More

J Med Imaging Radiat Oncol 2020 Jun 9;64(3):414-421. Epub 2020 May 9.

Trans Tasman Radiation Oncology Group, Newcastle, New South Wales, Australia.

Introduction: The global COVID-19 pandemic forced the cancellation of the TROG 2020 face to face Annual Scientific Meeting (ASM). It was instead delivered as a live virtual meeting with 6 days of planning. Here, we report the participants' experience of this live virtual meeting. Read More

Medicine (Baltimore) 2020 Apr;99(15):e19728

Department of Medical Ultrasound.

Background: The aim of this study was to present several cases of benign and malignant nipple lesions and contribute to diagnosis and differential diagnosis.

Methods: A retrospective study was conducted on 13 patients. All of the patients were evaluated by ultrasonography, and 11 of them had pathological results. Read More

Br J Radiol 2020 Jun 23;93(1110):20200063. Epub 2020 Apr 23.

Department of Radiology, King's College Hospital, London. Denmark Hill, London SE5 9RS U.K, United Kingdom.

Multiparametric ultrasound (MPUS), combining conventional techniques (greyscale and colour Doppler ultrasound), ultrasound strain elastography, and contrast-enhanced ultrasound (CEUS), has been successfully used in the assessment of adult scrotal pathology. Contrast-enhanced ultrasound can confidently establish testicular tissue vascularity even in the small-volume paediatric testis. Elastography provides further assessment of tissue stiffness, potentially adding useful diagnostic information. Read More

Surg Neurol Int 2020 28;11:29. Epub 2020 Feb 28.

Department of Neurosurgery, Beykoz Institute of Life Science and Biotechnology, Bezmialem Vakif University, İstanbul, Turkey.

Background: The aim of the study was to demonstrate the feasibility of integrating navigated transcranial magnetic stimulation (nTMS) in preoperative gamma knife radiosurgery (GKRS) planning of motor eloquent brain tumors.

Case Description: The first case was a 53-year-old female patient with metastatic breast cancer who developed focal epileptic seizures and weakness of the left hand. The magnetic resonance imaging (MRI) scan demonstrated a 30 mm metastasis neighboring the right precentral gyrus and central sulcus. Read More

Br J Radiol 2020 Jun 14;93(1110):20190869. Epub 2020 Apr 14.

Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden.

Objectives: To estimate risk for exposure-induced cancer death (REID), organ-specific risks of exposure-induced cancer death (REID) and associated conversion coefficients (CC=REID/kerma-area product (KAP), CC=REID/KAP) in paediatric cardiac catheterizations using data from radiation dose structured reports (RDSR). A novel risk surveillance tool consisting of age-specific and gender-specific risk reference values (RRVs) related to population cancer risk is suggested.

Methods: The PCXMC v. Read More

Eur Radiol 2020 Apr 3. Epub 2020 Apr 3.

Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Objectives: To evaluate the usefulness of bilateral mammography in male patients with unilateral breast symptoms, including investigation of the diagnostic performance of unilateral and bilateral reviews and the average glandular dose (AGD) per exposure.

Methods: Two hundred seventy-one consecutive male patients (mean age, 57 years) with unilateral breast symptoms underwent bilateral mammography. Image interpretation was performed in two ways, first with a unilateral review of the symptomatic breast and then with a bilateral review. Read More

PLoS One 2020 31;15(3):e0230553. Epub 2020 Mar 31.

Department of Diagnostic and Interventional Radiology, RWTH Aachen University Hospital, Aachen, Germany.

Objective: The purpose of this study was to investigate signal changes in T2-weighted magnetic resonance imaging of liver metastases under treatment with and without bevacizumab-containing chemotherapy and to compare these signal changes to tumor contrast enhancement.

Materials And Methods: Retrospective analysis of 44 patients, aged 36-84 years, who underwent liver magnetic resonance imaging including T2-weighted and dynamic contrast enhancement sequences. Patients received bevacizumab-containing (n = 22) or conventional cytotoxic chemotherapy (n = 22). Read More

Ann Ital Chir 2020 Mar 25;9. Epub 2020 Mar 25.

Aim: We aimed to evaluate; (i) the accuracy of ultrasonography (US), contrast-enhanced magnetic resonance imaging (cMRI) and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for detection of axillary lymph node metastases (ALNMs), (ii) the role of late prone imaging, and (iii) the effect of PET/CT on preoperative staging of breast cancer.

Material And Methods: From June 2015 to January 2019, 236 breast cancer patients were preoperatively exam ined using US, cMRI, and PET/CT and whom underwent pathological evaluations of axillary lymph nodes were analyzed. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy (ACC) of US, cMRI, and PET/CT for ALNMs were determined. Read More

Ann Ital Chir 2020 ;91:23-26

Purpose: Breast neuroendocrine carcinomas constitute approximately 0.3-0.5% of all breast cancers. Read More

Medicine (Baltimore) 2020 Mar;99(11):e19506

General Surgery, Qingdao West Coast New Area Central Hospital, Qingdao, China.

Rationale: Accessory breast cancer is extremely rare among all cancerous diseases, especially in male patients. There were only few male axillary accessory breast cancer cases that have been reported in scientific literatures so far. Hereby, we would like to discuss a case of male axillary accessory breast cancer found in our hospital. Read More

N Engl J Med 2020 Feb;382(9):856-864

From the Departments of Medicine (S.J.I., K.M.S.), Radiology (C.D.L.), and Pathology (K.M.B.), Massachusetts General Hospital, and the Departments of Medicine (S.J.I.), Radiology (C.D.L.), and Pathology (K.M.B.), Harvard Medical School - both in Boston.

Br J Radiol 2020 Apr 26;93(1108):20190948. Epub 2020 Feb 26.

The D-Lab & The M-Lab, Department of Precision Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Historically, medical imaging has been a qualitative or semi-quantitative modality. It is difficult to quantify what can be seen in an image, and to turn it into valuable predictive outcomes. As a result of advances in both computational hardware and machine learning algorithms, computers are making great strides in obtaining quantitative information from imaging and correlating it with outcomes. Read More

Tech Innov Patient Support Radiat Oncol 2019 Dec 16;12:56-63. Epub 2019 Dec 16.

The Royal Marsden NHS Foundation Trust, London, United Kingdom.

Objectives: To systematically identify the preferred magnetic resonance imaging (MRI) sequences following volunteer imaging on a 1.5 Tesla (T) MR-Linear Accelerator (MR Linac) for future protocol development.

Methods: Non-patient volunteers were recruited to a Research and Ethics committee approved prospective MR-only imaging study on a 1. Read More

J Clin Oncol 2020 Jun 14;38(16):1849-1863. Epub 2020 Feb 14.

MD Anderson Cancer Center, Houston, TX.

Purpose: To develop recommendations concerning the management of male breast cancer.

Methods: ASCO convened an Expert Panel to develop recommendations based on a systematic review and a formal consensus process.

Results: Twenty-six descriptive reports or observational studies met eligibility criteria and formed the evidentiary basis for the recommendations. Read More

J Comput Assist Tomogr 2020 May/Jun;44(3):450-461

The University of Texas MD Anderson Cancer Center, Houston, TX.

Objective: Rosai-Dorfman disease (RDD) is a rare and idiopathic nonneoplastic disease of histiocytes that is characterized by lymphadenopathy and extranodal disease. In this study, we documented anatomical preferences, imaging findings, comorbid diseases, and ethnic differences in 32 RDD patients.

Methods: We conducted a retrospective review of pathologically confirmed cases seen at our institution from 1998 to 2016. Read More

Mol Imaging Biol 2020 04;22(2):221-222

Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, 300 Pasteur Drive, H2200, Stanford, CA, 94305, USA.

Dis Colon Rectum 2020 02;63(2):183-189

Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio.

Background: Researchers are searching in vain for a coherent genetic explanation for serrated polyposis. We hypothesize that there is no consistent monogenetic inheritance.

Objective: The purpose of this study was to describe the serrated polyposis phenotype, assessing features of mendelian inheritance, and to compare these features with patients with a solitary sessile serrated lesion. Read More

Rom J Morphol Embryol 2019 ;60(3):1031-1037

Department of Psychiatry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Breast cancer is less common among men than among women (about 1 in 100) and it is considered a rare disease but the evolution is significantly influenced by depression and distress. We present the case of a 63-year-old patient that was diagnosed in another Clinic with squamous skin carcinoma, but, after complete resection in our Hospital, it was proven to be breast cancer. At diagnosis, computed tomography (CT) scan showed local disease. Read More

Neurology 2020 02 6;94(5):e521-e528. Epub 2020 Jan 6.

From the Division of Pharmacology (M.T.J.v.B., D.P., B.M.K., J.H.B., J.H.M.S.), Clinical Pharmacology (M.T.J.v.B., B.M.K., J.H.B., J.H.M.S), Division of Pathology (M.B.), Department of Biometrics (K.S.), Department of Laboratory Medicine (D.T.C.L., D.v.d.B.), and Department of Neuro-oncology (D.B.), Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam; and Science Faculty (J.H.B., J.H.M.S), Pharmaceutical Sciences, Division of Pharmaco-epidemiology and Clinical Pharmacology, Utrecht University, the Netherlands.

Objective: The primary objective was to determine the sensitivity and specificity of epithelial cell adhesion molecule (EpCAM) immunoflow cytometry circulating tumor cells (CTC) analysis in CSF in patients with suspected leptomeningeal metastases (LM). The secondary objective was to explore the distribution of driver mutations in the primary tumor, plasma, cell free CSF (cfCSF), and isolated CTC from CSF in non-small cell lung cancer (NSCLC).

Methods: We tested the performance of the CTC assay vs CSF cytology in a prospective study in 81 patients with a clinical suspicion of LM but a nonconfirmatory MRI. Read More

Anticancer Res 2020 Jan;40(1):75-80

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Background/aim: The aim of the present study was to compare human epidermal growth factor receptor 2 (HER2) expression before and after trastuzumab-based chemotherapy in patients with advanced HER2-positive gastric cancer.

Materials And Methods: We assessed HER2 expression using immunohistochemistry and/or fluorescence in situ hybridization in pre-treatment biopsied specimens and post-treatment resected specimens obtained from seven patients with advanced HER2-positive gastric cancer receiving trastuzumab-based chemotherapy.

Results: Four patients maintained the HER2-positive status and three patients had a change in HER2 expression from positive to negative. Read More

Clin Imaging 2020 Mar 28;60(1):84-89. Epub 2019 Nov 28.

Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA; University of Wisconsin Carbone Cancer Center, 600 Highland Avenue, Madison, WI 53792, USA; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705, USA.

Male breast cancer is a rare malignancy. Due to low prevalence and limited data to support male breast cancer screening, there are currently no recommendations for image-based screening in asymptomatic men and few recommendations for men at high risk for breast cancer. However, symptomatically diagnosed cancers in men are typically advanced, suggesting that earlier detection may improve outcomes. Read More

Rev Med Chil 2019 Jul;147(7):828-835

Departamento de Cirugía, Clínica Las Condes, Santiago, Chile.

Background: Colorectal cancer (CRC) is the third most prevalent cancer in the world and is the second cause of cancer death. Positron emission tomography/computed tomography (PET/CT) using 18F-FDG is used for its staging and follow up.

Aim: To assess the occurrence of synchronous colonic and extracolonic tumors detected with contrast-enhanced F18-FDG PET/CT (PET/CTc) in patients with a recently diagnosed CRC. Read More

Medicine (Baltimore) 2019 Dec;98(50):e18372

Department of Breast Surgery, The First Hospital of Jilin University, Changchun, Jilin Province, China.

Rationale: Mammary hamartoma is a rare benign breast tumor, composed of ducts, lobules, fibers, and adipose tissue. We describe a mammary hamartoma in a man; this is the fourth case being reported in the literature.

Patient Concerns: A 30-year-old man presented with a 1-month history of a painless mass in his right breast. Read More

Cancer Sci 2020 Feb 6;111(2):477-488. Epub 2020 Jan 6.

Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy,Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

ATP6L, the C subunit of the V-ATPase V0 domain, is involved in regulating the acidic tumor micro-environment and may promote tumor progression. However, the expression and functional role of ATP6L in tumors have not yet been well explored. In this study, we found that ATP6L protein overexpression was related to colorectal cancer histological differentiation (P < 0. Read More

Radiol Med 2020 Mar 10;125(3):280-287. Epub 2019 Dec 10.

Department of Biomedical and Dental Sciences and of Morphofunctional Imaging, University of Messina, Messina, Italy.

Objective: To report our experience with the use of intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE)-MRI in bone marrow before and after administration of granulocyte colony-stimulating factor (GCSF). Moreover, a small series of patients with bone metastases from breast cancer have been evaluated by IVIM DW-MRI and DCE-MRI before and after GCSF administration.

Materials And Methods: We studied with IVIM-MRI and DCE-MRI 14 patients with rectal or uterine cervix cancer studied before and 4-18 days after administration of GCSF; the second MR examination was obtained after three chemotherapy courses. Read More

PLoS One 2019 10;14(12):e0224457. Epub 2019 Dec 10.

Department of Biomedical Engineering, School of Electrical Engineering, University of Ulsan, Ulsan, Republic of Korea.

No method has yet been approved for detecting lymphedema fibrosis before its progression. This study assessed the feasibility of computed tomography-based estimation of fibrosis. This observational, cross-sectional study included patients with lymphedema affecting one limb. Read More

Med Sci Monit 2019 Dec 10;25:9416-9425. Epub 2019 Dec 10.

Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China (mainland).

BACKGROUND Esophageal cancer is a common cancer worldwide. We performed the present study to assess the homogeneous and heterogeneous risk and prognostic factors of bone metastasis (BM) in esophageal cancer patients using data extracted from the Surveillance, Epidemiology, and End Results (SEER) database. MATERIAL AND METHODS Data from patients with esophageal cancer in the SEER database from 2010 to 2016 were extracted to reveal the risk factors for BM through univariable and multivariable logistic regression. Read More

J Clin Imaging Sci 2019 6;9:46. Epub 2019 Nov 6.

Departments of Radiology, Medical University of South Carolina, Charleston, South Carolina, USA.

Pilomatrixoma or calcifying epithelioma of Malherbe is a benign skin tumor arising from the hair follicle; breast occurrence is considered a rarity. Clinically presenting as a palpable abnormality and with both benign and malignant mammographic and sonographic features, it can be easily misdiagnosed as a breast neoplasm. We report a very rare case of pilomatrixoma of the male breast in a 36-year-old male presenting with a firm, superficial nodule in the upper outer quadrant. Read More

Mol Imaging Biol 2020 04;22(2):219-220

Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Breast Cancer Res 2019 12 4;21(1):136. Epub 2019 Dec 4.

Department of Radiology, Breast Imaging Service, Memorial Sloan Kettering Cancer Center, Suite 705, 300 E 66th Street, New York, NY, 10065, USA.

Background: Available data proving the value of DWI for breast cancer diagnosis is mainly for enhancing masses; DWI may be less sensitive and specific in non-mass enhancement (NME) lesions. The objective of this study was to assess the diagnostic accuracy of DWI using different ROI measurement approaches and ADC metrics in breast lesions presenting as NME lesions on dynamic contrast-enhanced (DCE) MRI.

Methods: In this retrospective study, 95 patients who underwent multiparametric MRI with DCE and DWI from September 2007 to July 2013 and who were diagnosed with a suspicious NME (BI-RADS 4/5) were included. Read More

Med Ultrason 2019 Nov;21(4):491-493

Department of Radiology, Dokuz Eylul University School of Medicine, Izmir, Turkey.

Encapsulated solid papillary carcinoma (ESPC) is one of the malignant papillary lesions and classified it as ductal carcinoma in situ. Radiologic features of ESPC have been reported in the literature many times. However, to our best knowledge US elastography findings of ESPC have not been reported in the published literature yet. Read More

Plast Reconstr Surg 2019 12;144(6):975e-985e

Boston, Mass. From the Department of Surgery, Division of Plastic and Reconstructive Surgery, the Department of Medicine, Division of Cardiovascular Medicine, the Department of Radiology, Division of Magnetic Resonance Imaging, and the Department of Surgery/Breast Care Center, Beth Israel Deaconess Medical Center, Harvard Medical School.

Background: Lymphedema is a chronic condition that carries a significant physical, psychosocial, and economic burden. The authors' program was established in 2017 with the aims of providing immediate lymphatic reconstruction in high-risk patients undergoing lymphadenectomy and performing delayed lymphatic reconstruction in patients with chronic lymphedema. The purpose of this study was to describe the authors' clinical experience in the first year. Read More

BMC Gastroenterol 2019 Nov 14;19(1):187. Epub 2019 Nov 14.

Department of Medicine, Division of Gastroenterology, Showa University School of Medicine, Tokyo, Japan.

Background: Hepatic epithelioid hemangioendothelioma (HEH) is rare; it is reported in < 1 person in 1,000,000 individuals. For accurate diagnosis, information regarding multiple graphic modalities in HEH is required. However, there is very little information concerning Sonazoid® contrast enhanced ultrasonography (CEUS) in HEH. Read More

Tuberk Toraks 2019 Sep;67(3):211-218

Department of Chest Diseases, University of Health Science, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey.

Introduction: Although metastasis of extrapulmonary solid organ malignant tumors to the lungs is very common, endobronchial metastases are very rare. The most common extrapulmonary tumors that make endobronchial metastases are breast, kidney and colorectal carcinomas.

Materials And Methods: In this study, we retrospectively examined the data of eleven renal cell carcinoma patients who underwent endobronchial metastases in an eight-year period. Read More

Eur J Cancer 2019 12 2;123:130-137. Epub 2019 Nov 2.

Health Economics Unit, University of Birmingham, Edgbaston, West Midlands, UK. Electronic address:

Background: Mammographic screening reduces breast cancer mortality but may lead to the overdiagnosis and overtreatment of low-risk breast cancers. Conservative management may reduce the potential harm of overtreatment, yet little is known about the impact upon quality of life.

Objectives: To quantify women's preferences for managing low-risk screen detected ductal carcinoma in situ (DCIS), including the acceptability of active monitoring as an alternative treatment. Read More

Int J Pharm 2019 Dec 31;572:118791. Epub 2019 Oct 31.

Technical University of Denmark, Department of Health Technology, Center for Intestinal Absorption and Transport of Biopharmaceuticals, 2800 Kgs. Lyngby, Denmark.

Fluorinated graphene has recently gained much attention for cancer drug delivery, owing to its peculiar properties including high electronegativity difference, magnetic resonance imaging contrast agent, and the photothermal effect. However, the hydrophobic nature of fluorinated graphene greatly hinders its application as a biological material. Herein, a novel green method is reported for synthesis of a pH-sensitive charge-reversal and water-soluble fluorinated graphene oxide, modified with polyethyleneimine anchored to sericin-polypeptide (FPS). Read More

Cancer Res 2020 01 31;80(1):102-115. Epub 2019 Oct 31.

Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.

The sodium iodide symporter (NIS) is required for iodide uptake, which facilitates thyroid hormone biosynthesis. NIS has been exploited for over 75 years in ablative radioiodine (RAI) treatment of thyroid cancer, where its ability to transport radioisotopes depends on its localization to the plasma membrane. The advent of NIS-based imaging and theranostic strategies in other malignancies and disease modalities has recently increased the clinical importance of NIS. Read More

Chirurgia (Bucur) 2019 Sept-Oct;114(5):664-667

Fibromatosis is a benign lesion of the breast that can rarely occur in men, and requires good imaging and biopsy to make a differential diagnosis to breast carcinoma. Primary breast fibromatosis predominately affects females but can rarely affect the male breast (1,2). Due toits rarity, the condition has often been confused with breast carcinoma. Read More

Radiother Oncol 2019 12 22;141:283-291. Epub 2019 Oct 22.

Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Center of Molecular Imaging, Radiotherapy and Oncology (MIRO), Brussels, Belgium; Cliniques Universitaires Saint Luc, Department of Radiation Oncology, Brussels, Belgium.

Background And Purpose: Current motion mitigation strategies, like margins, gating, and tracking, deal with geometrical uncertainties in the tumour position, induced by breathing during radiotherapy (RT). However, they often overlook motion variability in amplitude, respiratory rate, or baseline position, when breathing spontaneously. Consequently, this may negatively affect the delivered dose conformality in comparison to the plan. Read More