5,469 results match your criteria Malaria Journal [Journal]


Spatiotemporal patterns of malaria at cross-boundaries area in Menoreh Hills, Java, Indonesia.

Malar J 2019 Mar 15;18(1):80. Epub 2019 Mar 15.

Graduate Program of Public Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Background: Comprehensive reports of malaria in Menoreh Hills, Central Java, Indonesia, a unique district cross-boundaries area under three districts and two provinces have been published previously. However, no study was performed to identify the hotspots of malaria in this cross-boundaries area, Kaligesing and Bagelen Subdistricts in Purworejo, Jawa Tengah Province and Kokap Subdistrict in Kulon Progo, Yogyakarta Province, using a longitudinal spatial data.

Methods: Monthly reports of malaria cases at primary health centres during 2005-2015 were collected and processed with ArcGIS and SaTScan to identify the malaria distribution at the village level. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2717-yDOI Listing
March 2019
1 Read

Characterizing local-scale heterogeneity of malaria risk: a case study in Bunkpurugu-Yunyoo district in northern Ghana.

Malar J 2019 Mar 15;18(1):81. Epub 2019 Mar 15.

School of Forest Resources and Conservation, University of Florida, Gainesville, USA.

Background: Bayesian methods have been used to generate country-level and global maps of malaria prevalence. With increasing availability of detailed malaria surveillance data, these methodologies can also be used to identify fine-scale heterogeneity of malaria parasitaemia for operational prevention and control of malaria.

Methods: In this article, a Bayesian geostatistical model was applied to six malaria parasitaemia surveys conducted during rainy and dry seasons between November 2010 and 2013 to characterize the micro-scale spatial heterogeneity of malaria risk in northern Ghana. Read More

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http://dx.doi.org/10.1186/s12936-019-2703-4DOI Listing

Avian malaria alters the dynamics of blood feeding in Culex pipiens mosquitoes.

Malar J 2019 Mar 15;18(1):82. Epub 2019 Mar 15.

Centre d'Ecologie Fonctionnelle et Evolutive (CEFE), UMR CNRS 5175, Montpellier, France.

Background: Some Plasmodium species have the ability to modify the behaviour of their mosquito vectors. This is thought to be an adaptive strategy that maximizes the parasite's transmission.

Methods: The effect of Plasmodium relictum infections on the blood feeding behaviour of Culex pipiens quinquefasciatus mosquitoes was monitored. Read More

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http://dx.doi.org/10.1186/s12936-019-2690-5DOI Listing

The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes.

Malar J 2019 Mar 14;18(1):79. Epub 2019 Mar 14.

Institute of Biology, University of Neuchâtel, Rue Emile-Argand 11, 2000, Neuchâtel, Switzerland.

Background: Insecticide-treated bed nets (ITNs) help to control malaria by mechanically impeding the biting of mosquitoes, by repelling and irritating them and by killing them. In contrast to spatial repellency, irritancy implies that mosquitoes contact the ITN and are exposed to at least a sub-lethal dose of insecticide, which impedes their further blood-seeking. This would weaken the transmission of malaria, if mosquitoes are infectious. Read More

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http://dx.doi.org/10.1186/s12936-019-2718-xDOI Listing

Geostatistical analysis and mapping of malaria risk in children under 5 using point-referenced prevalence data in Ghana.

Malar J 2019 Mar 11;18(1):67. Epub 2019 Mar 11.

Malawi-Liverpool Wellcome Trust Research Programme, Queen Elizabeth Central Hospital, Blantyre, Malawi.

Background: Malaria remains a major challenge in sub-Saharan Africa and Ghana is not an exception. Effective malaria transmission control requires evidence-based targeting and utilization of resources. Disease risk mapping provides an effective and efficient tool for monitoring transmission and control efforts. Read More

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http://dx.doi.org/10.1186/s12936-019-2709-yDOI Listing

Brain magnetic resonance imaging in imported malaria.

Malar J 2019 Mar 12;18(1):74. Epub 2019 Mar 12.

Divisions of Infectious Diseases and Tropical Medicine, I. Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Background: Previous studies have documented a spectrum of brain magnetic resonance imaging (MRI) abnormalities in patients with cerebral malaria, but little is known about the prevalence of such abnormalities in patients with non-cerebral malaria. The aim of this study was to assess the frequency of brain MRI findings in returning travellers with non-cerebral malaria.

Methods: A total of 17 inpatients with microscopically confirmed Plasmodium falciparum non-cerebral malaria underwent structural brain MRI at 3. Read More

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http://dx.doi.org/10.1186/s12936-019-2713-2DOI Listing

Persistence of chloroquine resistance alleles in malaria endemic countries: a systematic review of burden and risk factors.

Malar J 2019 Mar 12;18(1):76. Epub 2019 Mar 12.

Clinical Epidemiology Unit, Department of Medicine, Makerere University, P.O. Box 7072, Kampala, Uganda.

Background: Chloroquine, a previous highly efficacious, easy to use and affordable anti-malarial agent was withdrawn from malaria endemic regions due to high levels of resistance. This review collated evidence from published-reviewed articles to establish prevalence of Pfcrt 76T and Pfmdr-1 86Y alleles in malaria affected countries following official discontinuation of chloroquine use.

Methods: A review protocol was developed, registered in PROSPERO (#CRD42018083957) and published in a peer-reviewed journal. Read More

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http://dx.doi.org/10.1186/s12936-019-2716-zDOI Listing

In vivo compartmental kinetics of Plasmodium falciparum histidine-rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine-rich protein II.

Malar J 2019 Mar 13;18(1):78. Epub 2019 Mar 13.

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: The Plasmodium falciparum histidine-rich protein II (PfHRP2) is a common biomarker used in malaria rapid diagnostic tests (RDTs), but can persist in the blood for up to 40 days following curative treatment. The persistence of PfHRP2 presents a false positive limitation to diagnostic interpretation. However, the in vivo dynamics and compartmentalization underlying PfHRP2 persistence have not been fully characterized in the plasma and erythrocyte (RBC) fraction of the whole blood. Read More

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http://dx.doi.org/10.1186/s12936-019-2712-3DOI Listing

A comparison of thick-film microscopy, rapid diagnostic test, and polymerase chain reaction for accurate diagnosis of Plasmodium falciparum malaria.

Malar J 2019 Mar 12;18(1):73. Epub 2019 Mar 12.

Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.

Background: Accurate diagnosis of malaria is important for effective disease management and control. In Cameroon, presumptive clinical diagnosis, thick-film microscopy (TFM), and rapid diagnostic tests (RDT) are commonly used to diagnose cases of Plasmodium falciparum malaria. However, these methods lack sensitivity to detect low parasitaemia. Read More

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http://dx.doi.org/10.1186/s12936-019-2711-4DOI Listing

Rice farmers' perceptions and acceptability in the use of a combination of biolarvicide (Bacillus thuringiensis var. israeliensis) and fertilizers application for malaria control and increase rice productivity in a rural district of central Tanzania.

Malar J 2019 Mar 12;18(1):71. Epub 2019 Mar 12.

National Institute for Medical Research Headquarters, Dar es Salaam, Tanzania.

Background: The use of larval source management as a supplementary intervention for malaria control has not been widely used in rural Africa due to perceived high costs and complex logistics. To reduce the cost of larviciding in rice farming communities, concurrent application of biolarvicides and fertilizer in rice fields was introduced to control malaria vectors larvae and improve rice grain yields. The present study determined rice farmers' perceptions and acceptability in the use of a combination of biolarvicide and fertilizers in farming practices. Read More

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http://dx.doi.org/10.1186/s12936-019-2697-yDOI Listing

Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults.

Malar J 2019 Mar 12;18(1):69. Epub 2019 Mar 12.

Laboratory for Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Background: Immunity that limits malarial disease is acquired over time, but adults living in endemic areas continue to become infected and can require treatment for clinical illness. Gamma delta (γδ) T cells, particularly the Vδ2+ subset, have been associated with development of clinical malaria in children. In this study, the dynamics of total γδ T cells, Vδ2+ and Vδ2- T cells were measured during a malaria transmission season in Malian adults. Read More

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http://dx.doi.org/10.1186/s12936-019-2702-5DOI Listing

Biology of Plasmodium falciparum gametocyte sex ratio and implications in malaria parasite transmission.

Malar J 2019 Mar 12;18(1):70. Epub 2019 Mar 12.

Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Rome, Italy.

While significant advances have been made in understanding Plasmodium falciparum gametocyte biology and its relationship with malaria parasite transmission, the gametocyte sex ratio contribution to this process still remains a relevant research question. The present review discusses the biology of sex determination in P. falciparum, the underlying host and parasite factors, the sex specific susceptibility to drugs, the effect of sex ratio dynamics on malaria parasite transmission and the development of gametocyte sex specific diagnosis tools. Read More

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http://dx.doi.org/10.1186/s12936-019-2707-0DOI Listing

Prevalence of G6PD Viangchan variant in malaria endemic areas in Lao PDR: an implication for malaria elimination by 2030.

Malar J 2019 Mar 12;18(1):75. Epub 2019 Mar 12.

Department of Community and Global Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Primaquine is effective against the latent liver stage of Plasmodium vivax. Eliminating the latent liver stage of P. vivax is one of the necessary conditions to achieve the goal of malaria elimination in Lao People's Democratic Republic (PDR) by 2030. Read More

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http://dx.doi.org/10.1186/s12936-019-2715-0DOI Listing
March 2019
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Artisanal fishing supports breeding of malaria mosquitoes in Western Kenya.

Malar J 2019 Mar 12;18(1):77. Epub 2019 Mar 12.

Science for Health, P.O. Box 44970-00100, Nairobi, Kenya.

Background: Everyday hundreds of people, mainly men, set out to take part in a vibrant artisanal capture fishing (ACF) industry on Lake Victoria. It is not known whether actions of artisanal fishers, in their unrelenting quest for existence, surpass ecosystems' sustainability thresholds with potentially negative repercussions on human health with respect to malaria transmission potential. This article sought to fill this information gap. Read More

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http://dx.doi.org/10.1186/s12936-019-2708-zDOI Listing

Indoor residual spray bio-efficacy and residual activity of a clothianidin-based formulation (SumiShield 50WG) provides long persistence on various wall surfaces for malaria control in the Democratic Republic of the Congo.

Malar J 2019 Mar 12;18(1):72. Epub 2019 Mar 12.

China Molybdenum Co., Ltd./International SOS Malaria Control Programme, Tenke Fungurume Mining, Fungurume, Lualaba Province, Democratic Republic of the Congo.

Background: Bio-efficacy and residual activity of SumiShield 50WG (50%, w/w) with active ingredient clothianidin, a neonicotinoid compound, was assessed using an insecticide-susceptible laboratory strain of Anopheles arabiensis. Implications of the findings are examined in the context of potential alternative insecticides for indoor residual spraying in Lualaba Province, Democratic Republic of the Congo.

Methods: Contact surface bioassays were conducted for 48 weeks on four types of walls (unbaked clay, baked clay, cement, painted cement) in simulated semi-field experimental conditions using two different doses of clothianidin active ingredient (200 mg ai/sq m and 300 mg ai/sq m). Read More

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http://dx.doi.org/10.1186/s12936-019-2710-5DOI Listing

Exploring the heterogeneity of human exposure to malaria vectors in an urban setting, Bouaké, Côte d'Ivoire, using an immuno-epidemiological biomarker.

Malar J 2019 Mar 11;18(1):68. Epub 2019 Mar 11.

Institut Pierre Richet (IPR), Institut National de la Santé Publique (INSP), Bouaké, Côte d'Ivoire.

Background: In some African cities, urban malaria is a threat to the health and welfare of city dwellers. To improve the control of the disease, it is critical to identify neighbourhoods where the risk of malaria transmission is the highest. This study aims to evaluate the heterogeneity of malaria transmission risk in one city (Bouaké) in a West African country (Côte d'Ivoire) that presents several levels of urbanization. Read More

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http://dx.doi.org/10.1186/s12936-019-2696-zDOI Listing

Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae).

Malar J 2019 Mar 8;18(1):65. Epub 2019 Mar 8.

Malaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag x20, Hatfield, 0028, South Africa.

Background: Optimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of different sources of drugs in search of transmission-blocking agents. While plant species have been extensively investigated in search of malaria chemotherapeutic agents, comparatively less effort has been channelled towards exploring them in search of transmission-blocking drugs. Read More

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http://dx.doi.org/10.1186/s12936-019-2694-1DOI Listing

Human population movement and behavioural patterns in malaria hotspots on the Thai-Myanmar border: implications for malaria elimination.

Malar J 2019 Mar 8;18(1):64. Epub 2019 Mar 8.

Department of Population Health and Disease Prevention, University of California, Irvine, USA.

Background: Malaria is heterogeneously distributed across landscapes. Human population movement (HPM) could link sub-regions with varying levels of transmission, leading to the persistence of disease even in very low transmission settings. Malaria along the Thai-Myanmar border has been decreasing, but remains heterogeneous. Read More

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http://dx.doi.org/10.1186/s12936-019-2704-3DOI Listing

Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework.

Malar J 2019 Mar 8;18(1):66. Epub 2019 Mar 8.

School of Biological Sciences, University of Adelaide, Adelaide, Australia.

Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia. Recently, knowlesi malaria has become the predominant malaria affecting humans in Malaysian Borneo, being responsible for approximately 70% of reported cases. Largely as a result of anthropogenic land use changes in Borneo, vectors which transmit the parasite, along with macaque hosts, are both now frequently found in disturbed forest habitats, or at the forest fringes, thus having more frequent contact with humans. Read More

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http://dx.doi.org/10.1186/s12936-019-2693-2DOI Listing

Determinants of bed net use conditional on access in population surveys in Ghana.

Malar J 2019 Mar 8;18(1):63. Epub 2019 Mar 8.

Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box CH-4002, Basel, Switzerland.

Background: Insecticide-treated nets (ITNs) are one of the most effective and widely available methods for preventing malaria, and there is interest in understanding the complexities of behavioural drivers of non-use among those with access. This analysis evaluated net use behaviour in Ghana by exploring how several household and environmental variables relate to use among Ghanaians with access to a net.

Methods: Survey data from the Ghana 2014 Demographic and Health Survey and the 2016 Malaria Indicator Survey were used to calculate household members' access to space under a net as well as the proportion of net use conditional on access (NUCA). Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2700-7DOI Listing
March 2019
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K13-propeller gene polymorphisms in Plasmodium falciparum parasite population in malaria affected countries: a systematic review of prevalence and risk factors.

Malar J 2019 Mar 7;18(1):60. Epub 2019 Mar 7.

Clinical Epidemiology Unit, Department of Medicine, Makerere University, P.O. Box 7072, Kampala, Uganda.

Background: Efficacy of artemisinin (ART) agents, a critical element of current malaria control efforts is threatened by emergence and spread of resistance. Mutations in pfkelch13 gene associated with ART-resistance evolved in Southeast Asia (SEA). k13 mutations whose role in ART-resistance remains unknown, have subsequently emerged independently across all malaria-affected regions. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2701-6DOI Listing
March 2019
4 Reads

Investigating the upsurge of malaria prevalence in Zambia between 2010 and 2015: a decomposition of determinants.

Malar J 2019 Mar 7;18(1):61. Epub 2019 Mar 7.

School of Public Health, University of Zambia, Ridgeway Campus, Lusaka, Zambia.

Background: Malaria is among the top causes of mortality and morbidity in Zambia. Efforts to control, prevent, and eliminate it have been intensified in the past two decades which has contributed to reductions in malaria prevalence and under-five mortality. However, there was a 21% upsurge in malaria prevalence between 2010 and 2015. Read More

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http://dx.doi.org/10.1186/s12936-019-2698-xDOI Listing

UDP-glycosyltransferase genes and their association and mutations associated with pyrethroid resistance in Anopheles sinensis (Diptera: Culicidae).

Malar J 2019 Mar 7;18(1):62. Epub 2019 Mar 7.

Chongqing Key Laboratory of Vector Insects, Institute of Entomology and Molecular Biology, Chongqing Normal University, Chongqing, 401331, China.

Background: UDP-glycosyltransferase (UGT) is an important biotransformation superfamily of enzymes. They catalyze the transfer of glycosyl residues from activated nucleotide sugars to acceptor hydrophobic molecules, and function in several physiological processes, including detoxification, olfaction, cuticle formation, pigmentation. The diversity, classification, scaffold location, characteristics, phylogenetics, and evolution of the superfamily of genes at whole genome level, and their association and mutations associated with pyrethroid resistance are still little known. Read More

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http://dx.doi.org/10.1186/s12936-019-2705-2DOI Listing
March 2019
3.109 Impact Factor

Evaluation of MAGNet, a long-lasting insecticidal mosquito net against Anopheles fluviatilis in experimental huts in India.

Malar J 2019 Mar 6;18(1):59. Epub 2019 Mar 6.

ICMR-Vector Control Research Centre, Medical Complex, Indira Nagar, Puducherry, 605006, India.

Background: MAGNet LN is a wash resistant long-lasting insecticidal (polyethylene) net (LLIN) in which the alpha-cypermethrin insecticide is incorporated within the 150 denier high density polyethylene monofilaments of the nets. The bio-efficacy of MAGNet LN was reported to be high even after 25 washes. The LN met the WHO criteria of Phase I evaluation and obtained recommendation from the World Health Organization Pesticide Evaluation Scheme (WHOPES) for Phase II trial. Read More

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http://dx.doi.org/10.1186/s12936-019-2692-3DOI Listing
March 2019
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Acute interstitial nephritis with podocyte foot-process effacement complicating Plasmodium falciparum infection.

Malar J 2019 Mar 1;18(1):58. Epub 2019 Mar 1.

Department of Nephrology, University College Hospital, Galway, Republic of Ireland.

Background: Malarial acute renal failure (MARF) is a component of the severe malaria syndrome, and complicates 1-5% of malaria infections. This form of renal failure has not been well characterized by histopathology.

Case Presentation: A 44 year-old male presented to the emergency department with a 5-day history of fever and malaise after returning from Nigeria. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2674-5DOI Listing
March 2019
6 Reads

An update on glucose-6-phosphate dehydrogenase deficiency in children from Brazzaville, Republic of Congo.

Malar J 2019 Feb 28;18(1):57. Epub 2019 Feb 28.

Fondation Congolaise pour la Recherche Médicale (FCRM), Brazzaville, Republic of Congo.

Background: Malaria transmission-blocking anti-malarial drugs, such as primaquine, offers an effective strategy for reducing the incidence of falciparum malaria. However, this drug induces haemolytic anaemia among glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. The distribution of G6PD deficiency in Brazzaville, Republic of Congo and the association of G6PD deficiency with haemoglobin levels and blood cell counts were investigated. Read More

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http://dx.doi.org/10.1186/s12936-019-2688-zDOI Listing
February 2019
1 Read

Environmental and sociodemographic factors associated with household malaria burden in the Congo.

Malar J 2019 Feb 26;18(1):53. Epub 2019 Feb 26.

School of Medicine and Graduate School of Public Health, International University of Health and Welfare, Narita, Japan.

Background: Malaria is one of the most severe public health issues that result in massive morbidity and mortality in most countries of the sub-Saharan Africa (SSA). This study aimed to determine the scope of household, accessibility to malaria care and factors associated with household malaria in the Democratic Republic of Congo (DRC).

Methods: This was a community-based cross-sectional study conducted in an urban and a rural sites in which 152 households participated, including 82 urban and 70 rural households (1029 members in total). Read More

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http://dx.doi.org/10.1186/s12936-019-2679-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390528PMC
February 2019
1 Read

The impact of Anopheles gambiae egg storage for mass rearing and production success.

Malar J 2019 Feb 26;18(1):52. Epub 2019 Feb 26.

Department of Medical Parasitology, School of Medicine, Catholic University of Health and Allied Sciences-Bugando, P.O. Box 1464, Mwanza, Tanzania.

Background: Mass rearing requires a large colony from which male individuals can be harvested for sterilization and release. Attention is needed when monitoring life parameters of the reared population, knowing that any variations within the target population would lead to mismatching between two populations. The aim of this study was to assess the impact of Anopheles gambiae sensu stricto (s. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2691-4DOI Listing
February 2019
2 Reads

Impact of sunlight exposure on the residual efficacy of biolarvicides Bacillus thuringiensis israelensis and Bacillus sphaericus against the main malaria vector, Anopheles gambiae.

Malar J 2019 Feb 26;18(1):55. Epub 2019 Feb 26.

Institut Pierre Richet (IPR), Bouaké, Côte d'Ivoire.

Background: Biotic and abiotic factors have been reported to affect the larvicidal efficacy of Bacillus thuringiensis israelensis (Bti) and Bacillus sphaericus (Bs), although the extent to which they are affected has been poorly documented. This paper studies the effect of sunlight exposure on the efficacy of a new larvicide formulation based on both Bti and Bs, herein after referred to as BTBSWAX, applied against two different larval stages.

Methods: The emergence of inhibition exhibited by BTBSWAX at three different dosages (1 g/m, 1. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2687-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390594PMC
February 2019
1 Read
3.109 Impact Factor

'The mosquitoes are preparing to attack us': knowledge and perceptions of communities in south-eastern Tanzania regarding mosquito swarms.

Malar J 2019 Feb 26;18(1):56. Epub 2019 Feb 26.

Environmental Health and Ecological Science Department, Ifakara Health Institute, P. O. Box 53, Ifakara, Tanzania.

Background: Targeting swarms of male Anopheles mosquitoes with techniques such as aerosol spraying could potentially suppress malaria vector populations and parasite transmission. Unfortunately, research on Anopheles swarming behaviours is limited, particularly in East Africa where only a handful of studies have been done. New evidence has recently emerged that such swarms are common even in Tanzania, where they could be readily identified and characterized by community-based volunteers, and potentially targeted for control. Read More

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http://dx.doi.org/10.1186/s12936-019-2686-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390612PMC
February 2019

Environmental and meteorological factors linked to malaria transmission around large dams at three ecological settings in Ethiopia.

Malar J 2019 Feb 26;18(1):54. Epub 2019 Feb 26.

Department of Microbial, Cellular and Molecular Biology, College of Natural Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: A growing body of evidence suggests that dams intensify malaria transmission in sub-Saharan Africa. However, the environmental characteristics underpinning patterns in malaria transmission around dams are poorly understood. This study investigated local-scale environmental and meteorological variables linked to malaria transmission around three large dams in Ethiopia. Read More

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http://dx.doi.org/10.1186/s12936-019-2689-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390543PMC
February 2019
1 Read
3.109 Impact Factor

Evaluation of toxicity of clothianidin (neonicotinoid) and chlorfenapyr (pyrrole) insecticides and cross-resistance to other public health insecticides in Anopheles arabiensis from Ethiopia.

Malar J 2019 Feb 22;18(1):49. Epub 2019 Feb 22.

Entomology Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, 30329-4027, USA.

Background: Insecticide-based interventions play an integral role in malaria vector control. However, the continued spread of insecticide resistance threatens to undermine progress made thus far and may ultimately lead to operational failure of current control measures. Clothianidin and chlorfenapyr both have unique modes of action and have expanded the number of insecticide classes available to vector control programmes. Read More

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http://dx.doi.org/10.1186/s12936-019-2685-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387473PMC
February 2019

Assessment of the Suna trap for sampling mosquitoes indoors and outdoors.

Malar J 2019 Feb 22;18(1):51. Epub 2019 Feb 22.

College of Medicine, University of Malawi, Blantyre, Malawi.

Background: Entomological monitoring is important for public health because it provides data on the distribution, abundance and host-seeking behaviour of disease vectors. Various methods for sampling mosquitoes exist, most of which are biased towards, or specifically target, certain portions of a mosquito population. This study assessed the Suna trap, an odour-baited trap for sampling host-seeking mosquitoes both indoors and outdoors. Read More

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http://dx.doi.org/10.1186/s12936-019-2680-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387520PMC
February 2019
1 Read

The role of monitoring and evaluation to ensure functional access to community-based early diagnosis and treatment in a malaria elimination programme in Eastern Myanmar.

Malar J 2019 Feb 22;18(1):50. Epub 2019 Feb 22.

IRD, Aix Marseille Université, INSERM, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information, Médicale, Marseille, France.

Background: Improving access to early diagnosis and treatment (EDT) has increasingly proven to be a major contributor to decreasing malaria incidence in low-transmission settings. The Malaria Elimination Task Force (METF) has deployed malaria posts set up in Eastern Myanmar, providing free uninterrupted community-based access to EDT in more than 1200 villages. Ensuring high quality services are provided by these malaria posts is essential to reaching elimination targets. Read More

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http://dx.doi.org/10.1186/s12936-019-2677-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387481PMC
February 2019
3.109 Impact Factor

Malaria case management commodity supply and use by community health workers in Mozambique, 2017.

Malar J 2019 Feb 21;18(1):47. Epub 2019 Feb 21.

United States President's Malaria Initiative, US Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Community health workers (CHWs) provide preventive care and integrated community case management (iCCM) to people with low healthcare access worldwide. CHW programmes have helped reduce mortality in myriad countries, but little data on malaria supply chain management has been shared. This project evaluated the current composition, use, and delivery of malaria iCCM kit commodities in Mozambique-rapid diagnostic tests (RDTs) and artemether-lumefantrine (AL) treatments-to better tailor existing resources to the needs of CHWs in diverse practice settings. Read More

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http://dx.doi.org/10.1186/s12936-019-2682-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385463PMC
February 2019

On the discriminatory and predictive accuracy of the RDT against the microscopy in the diagnosis of malaria among under-five children in Nigeria.

Malar J 2019 Feb 21;18(1):46. Epub 2019 Feb 21.

Department of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: Accurate identification of malaria cases is crucial to the management of cases and the eventual success of malaria eradication agenda. This study is designed to evaluate the discriminatory and predictive accuracy of malaria rapid diagnostic tests (RDTs) in Nigeria.

Methods: The data obtained during the 2015 Nigeria Malaria Indicator Survey was used to quantify the discriminatory accuracy of the RDT against the microscopy through the analysis of its sensitivity, specificity, positive (LR+) and negative (LR-) likelihood ratio. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2678-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385408PMC
February 2019
4 Reads

Effectiveness of 24-h mobile reporting tool during a malaria outbreak in Mpumalanga Province, South Africa.

Malar J 2019 Feb 21;18(1):45. Epub 2019 Feb 21.

Department of Health, Malaria and Other Vector Borne Diseases, Pretoria, South Africa.

Background: As surveillance is a key strategy for malaria elimination in South Africa, ensuring strong surveillance systems is a National Department of Health priority. Historically, real time tracking of case trends and reporting within 24 h-a requirement in South Africa's National surveillance guidelines-has not been possible. To enhance surveillance and response efficiency, a mobile surveillance tool, MalariaConnect, was developed using Unstructured Supplementary Service Data (USSD) technology. Read More

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http://dx.doi.org/10.1186/s12936-019-2683-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385402PMC
February 2019

Effects and factors associated with indoor residual spraying with Actellic 300 CS on malaria morbidity in Lira District, Northern Uganda.

Malar J 2019 Feb 21;18(1):44. Epub 2019 Feb 21.

Department of Disease Control and Environmental Health, College of Health Sciences, School of Public Health, Makerere University, Kampala, Uganda.

Background: Indoor residual spraying (IRS) with Actellic 300 CS was conducted in Lira District between July and August 2016. No formal assessment has been conducted to estimate the effect of spraying with Actellic 300 CS on malaria morbidity in the Ugandan settings. This study assessed malaria morbidity trends before and after IRS with Actellic 300 CS in Lira District in Northern Uganda. Read More

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http://dx.doi.org/10.1186/s12936-019-2681-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383239PMC
February 2019
2 Reads

Association of high Plasmodium falciparum parasite densities with polyclonal microscopic infections in asymptomatic children from Toubacouta, Senegal.

Malar J 2019 Feb 21;18(1):48. Epub 2019 Feb 21.

Immunology Unit, Institut Pasteur Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal.

Background: Malaria is a leading cause of mortality and morbidity in tropical countries, especially in sub-Saharan Africa. In Senegal, a control plan implemented in the beginning of the 2000s has enabled a substantial reduction of mortality and morbidity due to malaria. However, eradication of malaria requires a vaccine that protects against Plasmodium falciparum the deadliest species of the parasite that causes this disease. Read More

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http://dx.doi.org/10.1186/s12936-019-2684-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385392PMC
February 2019

Effects of a health educational intervention on malaria knowledge, motivation, and behavioural skills: a randomized controlled trial.

Malar J 2019 Feb 20;18(1):41. Epub 2019 Feb 20.

Department of Obstetrics and Gynaecology, University of Maiduguri, Maiduguri, Nigeria.

Background: The levels of insecticide-treated net use among pregnant women and uptake of intermittent preventive treatment in pregnancy, have been sub-optimal in Nigeria. Previous studies have reported positive correlations between knowledge, attitude and practice of malaria preventive measures. It has also been reported that information and motivation, act through a mediator (behavioural skills), to cause a health behaviour change. Read More

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http://dx.doi.org/10.1186/s12936-019-2676-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381678PMC
February 2019

A comparative study of the prevalence of and factors associated with insecticide-treated nets usage among children under 5 years of age in households that already own nets in Malawi.

Malar J 2019 Feb 20;18(1):43. Epub 2019 Feb 20.

School of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.

Background: Despite malaria control programmes having successfully increased the number of households owning insecticide-treated nets (ITNs) in Malawi, the population of people with ITN access but still not using them fluctuated from 13% in 2010, 5% in 2012 and then 12% in 2015. This study aimed to compare the rate and factors associated with ITN usage among children under 5 years of age, living in household with at least one ITN, in Malawi between 2010 and 2015.

Methods: The 2010 and 2015-2016 Malawi Demographic and Health Surveys (MDHSs) were utilized. Read More

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http://dx.doi.org/10.1186/s12936-019-2667-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383286PMC
February 2019

Factors associated with children's health facility visits for primaquine treatment in rural Papua New Guinea.

Malar J 2019 Feb 20;18(1):42. Epub 2019 Feb 20.

Department of International Affairs and Tropical Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Background: To control and eventually eliminate vivax malaria, radical treatment with primaquine (PQ) is essential after completion of blood-stage treatment. Although in many malaria-endemic countries, village health volunteers (VHVs) are engaged in diagnostic treatment of malaria in remote communities, they principally provide blood-stage treatment. In such a situation, access to PQ following blood-stage treatment can be a barrier to complete treatment. Read More

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http://dx.doi.org/10.1186/s12936-019-2675-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383275PMC
February 2019
1 Read

Community perspectives on treating asymptomatic infections for malaria elimination in The Gambia.

Malar J 2019 Feb 18;18(1):39. Epub 2019 Feb 18.

Medical Anthropology Unit, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Innovative and cost-effective strategies that clear asymptomatic malaria infections are required to reach malaria elimination goals, but remain a challenge. This mixed methods study explored people's attitudes towards the reactive treatment of compound contacts of malaria cases with a 3-day course of dihydroartemisinin-piperaquine (DHAP), the socio-cultural representations of asymptomatic infections, and more specifically their treatment.

Methods: Prior to the start of the intervention, a sequential mixed method study was carried out. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2672-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378745PMC
February 2019
3 Reads
3.109 Impact Factor

Relationship between weight status and anti-malarial drug efficacy and safety in children in Mali.

Malar J 2019 Feb 18;18(1):40. Epub 2019 Feb 18.

Malaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), Bamako, Mali.

Background: Anti-malarial treatments effectiveness remains a critical challenge for control programmes. However, when drug efficacy is established, the dose is calculated based on a predefined weight according to the patient age. Based on the hypothesis that the standard assumption of weight according to the age when administering the drug could lead to a therapeutic failure potentially due to under-dosing (in the case of overweight) or over-dosing (in case of underweight). Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
Publisher Site
http://dx.doi.org/10.1186/s12936-019-2673-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380011PMC
February 2019
5 Reads

Updating the modified Thompson test by using whole-body bioluminescence imaging to replace traditional efficacy testing in experimental models of murine malaria.

Malar J 2019 Feb 15;18(1):38. Epub 2019 Feb 15.

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.

Background: Rodent malaria models are extensively used to predict treatment outcomes in human infections. There is a constant need to improve and refine these models by innovating ways to apply new scientific findings and cutting edge technologies. In addition, and in accordance with the three R's of animal use in research, in vivo studies should be constantly refined to avoid unnecessary pain and distress to the experimental animals by using preemptive euthanasia as soon as the main scientific study objective has been accomplished. Read More

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http://dx.doi.org/10.1186/s12936-019-2661-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376706PMC
February 2019
1 Read
3.109 Impact Factor

Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin.

Malar J 2019 Feb 11;18(1):37. Epub 2019 Feb 11.

MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.

Background: Insecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigated whether insecticide resistance was associated with increased incidence of clinical malaria.

Methods: In an area of southern Benin with insecticide resistance and high use of insecticide-treated nets (ITNs), malaria morbidity and insecticide resistance were measured simultaneously in 30 clusters (villages or collections of villages) multiple times over the course of 2 years. Read More

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http://dx.doi.org/10.1186/s12936-019-2656-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371432PMC
February 2019
1 Read
3.109 Impact Factor

Prescribing patterns and compliance with World Health Organization recommendations for the management of severe malaria: a modified cohort event monitoring study in public health facilities in Ghana and Uganda.

Malar J 2019 Feb 8;18(1):36. Epub 2019 Feb 8.

The African Collaborating Centre for Pharmacovigilance & Surveillance, Accra, Ghana.

Background: Injectable artesunate (AS) is the World Health Organization (WHO) recommended medication for the treatment of severe malaria followed with an oral artemisinin-based combination therapy (ACT). There are few studies indicating how physicians prescribe injectable AS, injectable quinine (Q) or injectable artemether (AR) and ACT for severe malaria. This study was undertaken to evaluate prescription compliance to the WHO recommendation in 8 public health facilities in Ghana and Uganda. Read More

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http://dx.doi.org/10.1186/s12936-019-2670-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368732PMC
February 2019
1 Read
3.109 Impact Factor

Effects of Azadirachta indica seed kernel extracts on early erythrocytic schizogony of Plasmodium berghei and pro-inflammatory response in inbred mice.

Malar J 2019 Feb 8;18(1):35. Epub 2019 Feb 8.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Background: Medicinal plant research may contribute to develop new pharmacological control tools for vector borne diseases, such as malaria.

Methods: The effects of methanol extracts (ME) obtained from seed kernel of ripe and unripe Azadirachta indica fruits were studied on erythrocytic proliferation of the rodent malaria parasite Plasmodium berghei strain ANKA and on mice pro-inflammatory response, as evaluated by measuring the matrix-metalloproteinase-9 (MMP-9) and tumour necrosis factor (TNF) plasma levels, in two mouse strains (C57BL/6 and BALB/c) which are considered as prototypical of Th1 and Th2 immune response, respectively.

Results: ME obtained from seed kernel of unripe Azadirachta indica fruits decreased by about 30% the proportion of erythrocytes infected with the malaria parasite in C57BL/6 mice in the 4 days suppressive test. Read More

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http://dx.doi.org/10.1186/s12936-019-2671-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368791PMC
February 2019
2 Reads
3.109 Impact Factor

Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study.

Malar J 2019 Feb 6;18(1):34. Epub 2019 Feb 6.

Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, 6140, South Africa.

Background: Treatment of parasitic diseases has been challenging due to evolution of drug resistant parasites, and thus there is need to identify new class of drugs and drug targets. Protein translation is important for survival of malarial parasite, Plasmodium, and the pathway is present in all of its life cycle stages. Aminoacyl tRNA synthetases are primary enzymes in protein translation as they catalyse amino acid addition to the cognate tRNA. Read More

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http://dx.doi.org/10.1186/s12936-019-2665-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366043PMC
February 2019
3.109 Impact Factor

Correction to: Performance of an ultra-sensitive Plasmodium falciparum HRP2-based rapid diagnostic test with recombinant HRP2, culture parasites, and archived whole blood samples.

Malar J 2019 Feb 4;18(1):33. Epub 2019 Feb 4.

Diagnostics Program, PATH, Seattle, WA, USA.

Following publication of the original article [1], the authors flagged an error concerning a reference to a product in the Methods section. Read More

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http://dx.doi.org/10.1186/s12936-019-2669-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362589PMC
February 2019