105,711 results match your criteria Malaria


What India can learn from globally successful malaria elimination programmes.

BMJ Glob Health 2022 Jun;7(6)

ICMR-National Institute of Malaria Research, New Delhi, Delhi, India

India is targeting malaria elimination by 2030. Understanding and adopting the strategies employed by countries that have successfully eliminated malaria can serve as a crucial thrust in this direction for a geographically diverse country like India. This analysis is based on extensive literature search on malaria elimination policies, strategies and programmes adopted by nine countries (China, El Salvador, Algeria, Argentina, Uzbekistan, Paraguay, Sri Lanka, Maldives and Armenia) which have attained malaria-free status over the past decade. Read More

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Should anti-malarial chemoprophylaxis be reimbursed in France? A cost-effectiveness analysis of different reimbursement strategies.

Infect Dis Now 2022 Jun 24. Epub 2022 Jun 24.

Service d'épidémiologie et de santé publique, CHU Rennes, France. Electronic address:

Objectives: France is the Western country with the highest number of imported malaria cases. This study evaluates the cost and effectiveness of the potential reimbursement of drugs for malaria chemoprophylaxis (CP). It targets travelers with medical insurance in France who are heading to endemic regions in sub-Saharan Africa (SSA), the cost of which is currently fully borne by these travelers. Read More

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Review: Liposomes in the prophylaxis and treatment of infectious diseases.

Life Sci 2022 Jun 24:120734. Epub 2022 Jun 24.

Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address:

Infectious diseases remain as one of the major burdens among health communities as well as in the general public despite the advances in prevention and treatment. Although vaccination and vector eliminations have greatly prevented the transmission of these diseases, the effectiveness of these strategies is no longer guaranteed as new challenges such as drug resistance and toxicity as well as the missing effective therapeutics arise. Hence, the development of new tools to manage these challenges is anticipated, in which nano technology using liposomes as effective nanostructure is highly considered. Read More

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Mosquito (Diptera: Culicidae) Larval Ecology in Rubber Plantations and Rural Villages in Dabou (Côte d'Ivoire).

Ecohealth 2022 Jun 27. Epub 2022 Jun 27.

Entomology and Herpetology Unit, Institut Pasteur of Côte d'Ivoire, 01 BP490 Abidjan01, Abidjan, Côte d'Ivoire.

In Côte d'Ivoire, rubber cultivation has more than doubled since 2010. These mass agricultural areas require a large workforce with little information on how this environment might impact risk of mosquito-borne diseases. The objective of this study was to assess the larval ecology of mosquitoes in rubber areas of Dabou, Côte d'Ivoire. Read More

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Strengthening vaccines and medicines manufacturing capabilities in Africa: challenges and perspectives.

EMBO Mol Med 2022 Jun 27:e16287. Epub 2022 Jun 27.

Department of Family Medicine, Suez Canal University, Ismailia, Egypt.

Africa carries a high burden of infectious diseases. Every year, millions of Africans contract tuberculosis, malaria, and many other diseases. Malaria kills hundreds of thousands of children under the age of five years annually. Read More

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Extracellular vesicles from malaria-infected red blood cells: not all are secreted equal.

EMBO Rep 2022 Jun 27:e55499. Epub 2022 Jun 27.

Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.

Extracellular vesicles (EVs) mediate the transfer of molecules between cells and play diverse roles in host-pathogen interactions. Malaria is an important disease caused by intracellular Plasmodium species that invade red blood cells and these red blood cells release EVs. The EVs from infected cells have diverse functions in the disease and an obstacle in understanding how they exert their functions is that multiple EV types exist. Read More

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Antimicrobial susceptibility testing profiles of ESBL-producing isolated from hospital and community adult patients in Blantyre, Malawi.

IJID Reg 2021 Dec 6;1:47-52. Epub 2021 Sep 6.

Department of Pathology, College of Medicine, Kamuzu University of Health Sciences, Private Bag 360, Blantyre, Malawi.

Objective: There is a paucity of data on antimicrobial resistance (AMR) in Malawi. Here we present a study of AMR of extended-spectrum β-lactamases-producing (ESBL-E) isolated from hospital and community settings in Blantyre, Malawi.

Design And Methods: A cross-sectional study was conducted between March and November 2020, involving 403 adult participants aged ≥18 years. Read More

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December 2021

Meta-Analysis of Human Antibodies Against Variable Surface and Merozoite Stage Antigens.

Front Immunol 2022 9;13:887219. Epub 2022 Jun 9.

Division of Cell-Free Sciences, Proteo-Science Center, Ehime University, Matsuyama, Japan.

Concerted efforts to fight malaria have caused significant reductions in global malaria cases and mortality. Sustaining this will be critical to avoid rebound and outbreaks of seasonal malaria. Identifying predictive attributes that define clinical malaria will be key to guide development of second-generation tools to fight malaria. Read More

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suPAR to Risk-Stratify Patients With Malaria.

Front Immunol 2022 10;13:931321. Epub 2022 Jun 10.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Severe malaria (SM) is a leading cause of global morbidity and mortality, particularly in children in sub-Saharan Africa. However, existing malaria diagnostic tests do not reliably identify children at risk of severe and fatal outcomes. Dysregulated host immune and endothelial activation contributes to the pathogenesis of SM. Read More

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Multiplex Serology for Measurement of IgG Antibodies Against Eleven Infectious Diseases in a National Serosurvey: Haiti 2014-2015.

Front Public Health 2022 9;10:897013. Epub 2022 Jun 9.

Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, United States.

Background: Integrated surveillance for multiple diseases can be an efficient use of resources and advantageous for national public health programs. Detection of IgG antibodies typically indicates previous exposure to a pathogen but can potentially also serve to assess active infection status. Serological multiplex bead assays have recently been developed to simultaneously evaluate exposure to multiple antigenic targets. Read More

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MULTIVARIATE MIXED MEMBERSHIP MODELING: INFERRING DOMAIN-SPECIFIC RISK PROFILES.

Ann Appl Stat 2022 Mar 28;16(1):391-413. Epub 2022 Mar 28.

Duke University.

Characterizing the shared memberships of individuals in a classification scheme poses severe interpretability issues, even when using a moderate number of classes (say 4). Mixed membership models quantify this phenomenon, but they typically focus on goodness-of-fit more than on interpretable inference. To achieve a good numerical fit, these models may in fact require many extreme profiles, making the results difficult to interpret. Read More

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Vaccine dilemma for children at risk: Recently approved malaria vaccine versus ongoing COVID-19 vaccination campaign.

Ann Med Surg (Lond) 2022 Jul 18;79:104011. Epub 2022 Jun 18.

Kabul University of Medical Sciences, Kabul, Afghanistan.

Recently, the World Health Organization (WHO) approved RTS, S/AS01 (RTS, S) as the world's first malaria vaccine for partial malaria protection in young children at risk. While this immunization drive begins during the unprecedented pandemic of the SARS-CoV-2 Virus, the WHO has also approved 7 Vaccines in 2021 for the vaccination of children at risk. This article explores the quandary that would occur to the officials in charge of carrying out large vaccination campaigns against these two deadly infectious illnesses in several regions including the continent of Africa. Read More

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Songbird preen oil odour reflects haemosporidian parasite load.

Anim Behav 2022 Jun 11;188:147-155. Epub 2022 May 11.

Department of Biology, Indiana University, Bloomington, IN, U.S.A.

Investigating the impact of parasitism on host phenotype is key to understanding parasite transmission ecology, host behavioural ecology and host-parasite coevolution. Previous studies have provided evidence that avian odour is one such phenotypic trait, as mosquitoes that vector the haemosporidian blood parasite tend to prefer birds that are already infected. Preen oil is a major source of avian odour, yet studies to date have not identified differences in preen oil odour based on the presence or absence of haemosporidian infection. Read More

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Multifunctional Roles of MicroRNAs in Schistosomiasis.

Front Microbiol 2022 9;13:925386. Epub 2022 Jun 9.

National Reference Laboratory for Animal Schistosomiasis, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.

Schistosomiasis is a parasitic disease that is caused by helminths of the genus . The dioecious schistosomes mate and lay eggs after undergoing a complex life cycle. Schistosome eggs are mostly responsible for the transmission of schistosomiasis and chronic fibrotic disease induced by egg antigens is the main cause of the high mortality rate. Read More

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Adapt or Die: Targeting Unique Transmission-Stage Biology for Malaria Elimination.

Front Cell Infect Microbiol 2022 9;12:901971. Epub 2022 Jun 9.

Institute for Sustainable Malaria Control, School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa.

parasites have a complex life cycle that includes development in the human host as well as the vector. Successful transmission of the parasite between its host and vector therefore requires the parasite to balance its investments in asexual replication and sexual reproduction, varying the frequency of sexual commitment to persist within the human host and generate future opportunities for transmission. The transmission window is extended further by the ability of stage V gametocytes to circulate in peripheral blood for weeks, whereas immature stage I to IV gametocytes sequester in the bone marrow and spleen until final maturation. Read More

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Labeling Strategies for Surface-Exposed Protein Visualization and Determination in Malaria.

Authors:
Jinfeng Shao

Front Cell Infect Microbiol 2022 10;12:914297. Epub 2022 Jun 10.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States.

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Successful Oral Antimalarial Therapy in A 14-Year-Old Child with Blackwater Fever: A Case in a Rural Area of Asmat Regency of Papua, Indonesia: Successful Oral Antimalarial in Blackwater Fever.

IJID Reg 2022 Jun 31;3:157-159. Epub 2022 Mar 31.

Department of Child Health, Regional Public Hospital of Agats, Asmat Regency, Papua, Indonesia.

Background: Blackwater fever (BWF) is one of the severe forms of malaria manifested by hemoglobinuria that causes dark-colored urine, fever, anemia, jaundice and acute kidney injury. BWF is most commonly associated with infection and its treatment. Parenteral antimalarial therapy is recommended as the treatment of choice for BWF. Read More

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Seroprevalence of chikungunya virus among military personnel in Papua New Guinea, 2019.

IJID Reg 2022 Jun 4;3:34-36. Epub 2022 Mar 4.

Australian Defence Force Malaria and Infectious Disease Institute, Enoggera, Brisbane, Queensland, Australia.

Objectives: The first outbreak of chikungunya virus (CHIKV) was reported in West Sepik, Papua New Guinea (PNG) in June 2012, and spread rapidly throughout PNG. CHIKV imported from PNG to Queensland has been reported occasionally, but transmission of CHIKV in PNG remains unclear due to the lack of testing capability. This study investigated the degree of CHIKV exposure among PNG military personnel (PNGMP) in 2019, 7 years after its first emergence. Read More

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histidine-rich protein 2 and 3 gene deletion in the Mount Cameroon region.

IJID Reg 2022 Jun 20;3:300-307. Epub 2022 May 20.

Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, P.O. Box 63, Buea, South West Region of Cameroon.

Objective: produces histidine-rich protein 2/3 () genes that accumulate to high levels in the bloodstream and serve as a diagnostic and prognostic marker for malaria. gene deletions may lead to false-negative rapid diagnostic test (RDT) results. We aimed to determine the prevalence of / gene deletions in isolates and the implications for RDT use in the Mount Cameroon region. Read More

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Delayed diagnosis of severe falciparum malaria in a patient presenting with acute gastroenteritis in West Texas.

Proc (Bayl Univ Med Cent) 2022 22;35(4):543-544. Epub 2022 Mar 22.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.

Falciparum malaria is a life-threatening infection that affects both people in endemic areas and people who travel to endemic areas. Malaria in exceedingly rare in West Texas, but the initial recognition and prompt initiation of antimalarial treatment are crucial in managing malaria. Here we present a case of a 31-year-old woman who was initially diagnosed with acute gastroenteritis and was later found to have cerebral malaria. Read More

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Evaluating recurrent episodes of malaria incidence in Timika, Indonesia, through a Markovian multiple-state model.

Infect Dis Model 2022 Sep 6;7(3):261-276. Epub 2022 Jun 6.

Department of Statistics, Faculty of Mathematics and Natural Science, Universitas Islam Indonesia, Jalan Kaliurang Km 14.5 Sleman, Yogyakarta, 55584, Indonesia.

Background: The high prevalence of malaria in endemic areas generally stems from recurrence events, characterized by the appearance of malaria symptoms at the time of examination; nearly every resident is at risk of experiencing such a recurrence. The verified presence of sp is referred to as the Confirmed state, while the condition without confirmed is called the Undetected Parasitaemia state. After malaria treatment, a person can be in Aparasitaemic state or return to an Undetected Parasitaemia or Confirmed state due to non-adherence in complying with malaria therapy. Read More

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September 2022

Reduced performance of community bednets against pyrethroid-resistant Anopheles funestus and Anopheles gambiae, major malaria vectors in Cameroon.

Parasit Vectors 2022 Jun 26;15(1):230. Epub 2022 Jun 26.

Centre for Research in Infectious Diseases (CRID), P.O. Box 13501, Yaoundé, Cameroon.

Background: Long-lasting insecticidal nets (LLINs) are a vital tool in the fight against malaria vectors. However, their efficacy in the field can be impacted by several factors, including patterns of usage, net age, mosquito resistance and the delayed mortality effect, all of which could influence malaria transmission. We have investigated the effectiveness of the various brands of LLINs available in markets and households in Cameroon on pyrethroid-resistant mosquitoes and assessed their post-exposure effect. Read More

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Population genetic structure and evolutionary genetics of Anopheles sinensis based on knockdown resistance (kdr) mutations and mtDNA-COII gene in China-Laos, Thailand-Laos, and Cambodia-Laos borders.

Parasit Vectors 2022 Jun 26;15(1):229. Epub 2022 Jun 26.

Department of Tropical Diseases, Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.

Background: Vector control is still a pivotal method for preventing malaria, and its potency is weakened by the increasing resistance of vectors to chemical insecticides. As the most abundant and vital malaria vector in Southeast Asia, the chemical insecticide resistance status in Anopheles sinensis remains elusive in Laos, which makes it imperative to evaluate the true nature of chemical insecticide resistance-associated genetic mutations in An. sinensis in Laos. Read More

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Global impact of the first year of COVID-19 vaccination: a mathematical modelling study.

Lancet Infect Dis 2022 Jun 23. Epub 2022 Jun 23.

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.

Background: The first COVID-19 vaccine outside a clinical trial setting was administered on Dec 8, 2020. To ensure global vaccine equity, vaccine targets were set by the COVID-19 Vaccines Global Access (COVAX) Facility and WHO. However, due to vaccine shortfalls, these targets were not achieved by the end of 2021. Read More

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Efficacy of RTS,S/AS01 malaria vaccine administered according to different full, fractional, and delayed third or early fourth dose regimens in children aged 5-17 months in Ghana and Kenya: an open-label, phase 2b, randomised controlled trial.

Lancet Infect Dis 2022 Jun 23. Epub 2022 Jun 23.

Kwame Nkrumah University of Science and Technology/Agogo Presbyterian Hospital, Agogo, Asante Akyem, Ghana.

Background: Controlled infection studies in malaria-naive adults suggest increased vaccine efficacy for fractional-dose versus full-dose regimens of RTS,S/AS01. We report first results of an ongoing trial assessing different fractional-dose regimens in children, in natural exposure settings.

Methods: This open-label, phase 2b, randomised controlled trial is conducted at the Malaria Research Center, Agogo, Ashanti Region (Ghana), and the Kenya Medical Research Institute and the US Centers for Disease Control and Prevention site in Siaya County (Kenya). Read More

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Health outcomes associated with micronutrient-fortified complementary foods in infants and young children aged 6-23 months: a systematic review and meta-analysis.

Lancet Child Adolesc Health 2022 Jun 23. Epub 2022 Jun 23.

Cochrane Hungary, University of Pécs, Pécs, Hungary; Department of Public Health Medicine, University of Pécs, Pécs, Hungary. Electronic address:

Background: Appropriate feeding of infants and young children is essential for healthy growth and the prevention of stunting, wasting, and overweight. We aimed to assess the beneficial versus harmful effects of providing fortified complementary foods to children in the complementary feeding period.

Methods: In this systematic review and meta-analysis, we searched the databases Cochrane Central Register of Controlled Trials, MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, Global Index Medicus, Web of Science, ClinicalTrials. Read More

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[Consensus document for the management of schistosomiasis in Primary Care].

Aten Primaria 2022 Jun 23;54(8):102408. Epub 2022 Jun 23.

Servicio Enfermedades Infecciosas, Hospital Universitario de Donostia/Donostia unibertsitate ospitalea, EHU-UPV, Biodonostia, Gipuzkoa, SEMTSI, Donostia-San Sebastian, España.

Human schistosomiasis is the parasitic disease with the highest morbidity and mortality worldwide after malaria. It is endemic in more than 78 tropical and subtropical countries, especially in sub-Saharan Africa, and it is estimated that 236 million people are infected. It can cause serious health complications at the genitourinary and hepatosplenic level, leading to the death of 300,000 people each year. Read More

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Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya.

Trop Med Health 2022 Jun 25;50(1):41. Epub 2022 Jun 25.

University of New Mexico-Kenya Global Health Programs, Kisumu, Siaya, Kenya.

Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte-macrophage colony-stimulating factor (GM-CSF), a hematopoietic growth factor that mediates host immune responses. Read More

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A malaria-free China: global importance and key experience.

Adv Parasitol 2022 ;116:xv-xix

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, PR China; School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. Electronic address:

Malaria has a worldwide distribution and is the world's deadliest mosquito-borne disease. The goal of malaria elimination is also reflected in the United Nations Sustainable Development Goals and the Global Technical Strategy for Malaria 2016-2030 issued by the World Health Organization (WHO). China succeeded in its malaria elimination programme after being certified as malaria-free by the WHO on 30 June 2021. Read More

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Surveillance and response systems driving malaria elimination in the mountain areas of Hainan Province.

Adv Parasitol 2022 18;116:69-113. Epub 2022 Mar 18.

Hainan Provincial Center for Disease Control & Prevention, Haikou, Hainan, PR China. Electronic address:

Hainan Province is in a tropical area of China and previously experienced serious P. falciparum and P. vivax malaria epidemics. Read More

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