91,113 results match your criteria Malaria


In vitro susceptibility of Plasmodium falciparum isolates from the China-Myanmar border area to artemisinins and correlation with K13 mutations.

Int J Parasitol Drugs Drug Resist 2019 Apr 10;10:20-27. Epub 2019 Apr 10.

Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, Yunnan Province, 650500, China. Electronic address:

Mutations in the Kelch domain of the K13 gene (PF3D7_1343700) were previously associated with artemisinin resistance in Plasmodium falciparum. This study followed the dynamics of the K13 polymorphisms in P. falciparum parasites from the China-Myanmar border area obtained in 2007-2016, and their in vitro sensitivities to artesunate (AS) and dihydroartemisinin (DHA). Read More

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http://dx.doi.org/10.1016/j.ijpddr.2019.04.002DOI Listing

A path to cooperation between China and Mongolia towards the control of echinococcosis under the Belt and Road Initiative.

Acta Trop 2019 Apr 19. Epub 2019 Apr 19.

London School of Hygiene and Tropical Medicine, United Kingdom.

Health is the core of development. Health cooperation between countries plays a pivotal role under the 'Belt and Road' Initiative. In 2013, China launched its Belt and Road Initiative to improve the international cooperation of which health was an important component. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183108
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http://dx.doi.org/10.1016/j.actatropica.2019.04.022DOI Listing
April 2019
1 Read

Dust or disease? Perceptions of influenza in rural Southern Malawi.

PLoS One 2019 22;14(4):e0208155. Epub 2019 Apr 22.

Malawi Liverpool Welcome Trust Clinical Research Programme, Chichiri, Blantyre 3, Malawi.

Influenza virus infections cause between 291 243 and 645 832 deaths annually, with the highest burden in low-income settings. Research in high-income countries has examined public understanding of influenza, but there is little information on views and behaviours about influenza in low-income countries. We explored communities' ideas about the severity, causes, prevention and treatment of influenza in Chikwawa district, Malawi. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208155PLOS

A cross-sectional survey on the seroprevalence of dengue fever in febrile patients attending health facilities in Cross River State, Nigeria.

PLoS One 2019 22;14(4):e0215143. Epub 2019 Apr 22.

Nuffield Centre for International Health and Development, University of Leeds, Leeds, United Kingdom.

Background: In Nigeria, recent reports suggest that dengue viruses could be a major cause of acute fevers. We sought to make a cross-sectional estimate of the prevalence of current and previous dengue infections in patients presenting with fever to healthcare centres in Cross River State Nigeria.

Methodology/principal Findings: This cross-sectional health facility survey recruited persons with temperature ≥38°C. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215143PLOS

Complex malaria epidemiology in an international border area between Brazil and French Guiana: challenges for elimination.

Trop Med Health 2019 11;47:24. Epub 2019 Apr 11.

Laboratory of Parasitic Diseases, Institute Oswaldo Cruz/Fiocruz, Av Brasil 4365. Pavilhão Arthur Neiva, Rio de Janeiro, RJ 21040-900 Brazil.

Background: The epidemiological surveillance of malaria is a necessary intervention for eliminating the disease from the planet. The international border zones of the Amazon continue to be highly vulnerable to malaria since population mobility impedes elimination. Although in the past few years, cases of malaria have had an essential reduction in Brazil, this trend was not confirmed in municipalities along the border. Read More

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http://dx.doi.org/10.1186/s41182-019-0150-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458633PMC

Genetic structure of populations following the use of insecticides on several consecutive years in southern Benin.

Trop Med Health 2019 11;47:23. Epub 2019 Apr 11.

Cotonou Entomological Research Center (CREC), Cotonou, Benin.

Background: Several studies have reported the strong resistance of complex species to pyrethroids. The voltage-dependent sodium channel () gene is the main target of pyrethroids and DDT. In Benin, the frequency of the resistant allele () of this gene varies along the north-south transect. Read More

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http://dx.doi.org/10.1186/s41182-019-0151-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458727PMC

Increasing Complexity Threatens the Elimination of Extra-Amazonian Malaria in Brazil.

Trends Parasitol 2019 Apr 18. Epub 2019 Apr 18.

Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address:

Extra-Amazonian malaria has been reported to be endemic in Brazil since the end of the 19th century. Currently, only a few cases are reported annually. However, recent findings of unexpected Plasmodium infections with uncertain transmission cycles in the Extra-Amazonian region could pose a threat to the malaria elimination agenda in Brazil. Read More

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http://dx.doi.org/10.1016/j.pt.2019.03.009DOI Listing

Nutrition in transition: historical cohort analysis summarising trends in under- and over-nutrition among pregnant women in a marginalised population along the Thailand-Myanmar border from 1986 to 2016.

Br J Nutr 2019 Apr 22:1-26. Epub 2019 Apr 22.

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine,Mahidol University,Mae Sot, 63110,Thailand.

The objective of this study is to summarise trends in under- and over- nutrition in pregnant women on the Thailand-Myanmar border. Refugees contributed data from 1986-2016 and migrants from 1999-2016 for weight at first antenatal consultation. Body mass index (BMI) and gestational weight gain (GWG) data were available during 2004-2016 when height was routinely measured. Read More

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http://dx.doi.org/10.1017/S0007114519000758DOI Listing

[Epidemiological characteristics of imported acute infectious diseases in the border areas of Yunnan province, 2008-2017].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Apr;40(4):412-416

Epidemic Surveillance/Emergency Public Health Disposal Center, Yunnan Province Centre for Disease Control and Prevention, Kunming 650022, China.

To understand the epidemiological characteristics of imported acute infectious diseases between 2008 and 2017 in the border areas of Yunnan province. All the cases occurred between January 2008 and December 2017 and related information was from the Chinese CDC infectious disease report information management system, according to definition of imported cases diagnosed by clinicians. Epidemiological characteristics of the imported cases of related information were gathered. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.04.008DOI Listing

Immune Activation and Microbial Translocation Markers in HIV-Exposed Uninfected Malawian Infants in the First Year of Life.

J Trop Pediatr 2019 Apr 21. Epub 2019 Apr 21.

National Center for Global Health, Istituto Superiore di Sanità, Rome 00161, Italy.

Background: HIV-exposed uninfected (HEU) infants show a high rate of morbidity. We aimed to investigate on biomarkers of immune activation/microbial translocation in HEU infants, evaluating the impact that infections/malnutrition can have on biomarker levels during the first year of life.

Methods: Clinical data of 72 Malawian infants were recorded monthly and correlated with levels of soluble CD14 (sCD14), lipopolysaccharide-binding protein (LBP) and intestinal fatty acid-binding protein (I-FABP), analyzed longitudinally. Read More

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https://academic.oup.com/tropej/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/tropej/fmz022DOI Listing
April 2019
1 Read

Clinical activity at the UK military level 2 hospital in Bentiu, South Sudan during Op TRENTON from June to September 2017.

J R Army Med Corps 2019 Apr 20. Epub 2019 Apr 20.

Academic Department of Military Medicine, Royal Centre for Defence Medicine, Birmingham, UK.

Introduction: Diseases and non-battle injuries (DNBIs) are common on UK military deployments, but the collection and analysis of clinically useful data on these remain a challenge. Standard medical returns do not provide adequate clinical information, and clinician-led approaches have been laudable, but not integrated nor standardised nor used long-term. Op TRENTON is a novel UK military humanitarian operation in support of the United Nations Mission in South Sudan, which included the deployment of UK military level 1 and level 2 medical treatment facilities at Bentiu to provide healthcare for UK and United Nations (UN) personnel. Read More

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http://dx.doi.org/10.1136/jramc-2018-001154DOI Listing

Molecular Imaging of a Zirconium-89 Labeled Antibody Targeting Plasmodium falciparum-Infected Human Erythrocytes.

Mol Imaging Biol 2019 Apr 19. Epub 2019 Apr 19.

Preclinical Imaging Facility, The South African Nuclear Energy Corporation SOC Ltd (Necsa), Pelindaba, South Africa.

Purpose: Nuclear imaging is an important preclinical research tool to study infectious diseases in vivo and could be extended to investigate complex aspects of malaria infections. As such, we report for the first time successful radiolabeling of a novel antibody specific to Plasmodium-infected erythrocytes (IIIB6), its in vitro assessment and molecular imaging in nude mice.

Procedures: In vitro confocal microscopy was used to determine the stage-specificity of Plasmodium-infected erythrocytes recognised by IIIB6. Read More

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http://link.springer.com/10.1007/s11307-019-01360-3
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http://dx.doi.org/10.1007/s11307-019-01360-3DOI Listing
April 2019
2 Reads

Modelling changes in glutathione homeostasis as a function of quinone redox metabolism.

Sci Rep 2019 Apr 19;9(1):6333. Epub 2019 Apr 19.

Department of Applied Mathematics, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.

Redox cycling is an understated mechanism of toxicity associated with a plethora of xenobiotics, responsible for preventing the effective treatment of serious conditions such as malaria and cardiomyopathy. Quinone compounds are notorious redox cyclers, present in drugs such as doxorubicin, which is used to treat a host of human cancers. However, the therapeutic index of doxorubicin is undermined by dose-dependent cardiotoxicity, which may be a function of futile redox cycling. Read More

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http://www.nature.com/articles/s41598-019-42799-2
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http://dx.doi.org/10.1038/s41598-019-42799-2DOI Listing
April 2019
1 Read

Interaction of RNA viruses of the natural virome with the African malaria vector, Anopheles coluzzii.

Sci Rep 2019 Apr 19;9(1):6319. Epub 2019 Apr 19.

Department of Parasites and Insect Vectors, Unit of Genetics and Genomics of Insect Vectors, Institut Pasteur, Paris, 75724 CEDEX 15, France.

Mosquitoes are colonized by a little-studied natural virome. Like the bacterial microbiome, the virome also probably influences the biology and immunity of mosquito vector populations, but tractable experimental models are lacking. We recently discovered two novel viruses in the virome of wild Anopheles and in colonies of the malaria vector Anopheles coluzzii: Anopheles C virus and Anopheles cypovirus. Read More

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http://dx.doi.org/10.1038/s41598-019-42825-3DOI Listing

Elucidating Host Cell Uptake by Malaria Parasites.

Trends Parasitol 2019 Apr 16. Epub 2019 Apr 16.

Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address:

The malaria parasite must digest host cytoplasm for normal growth, and many studies have revealed the essential role of proteases in hemoglobin digestion. Here, we discuss the results of Jonscher et al. (Cell Host Microbe 2019;25:166-173) who have, for the first time, identified a molecule, VPS45, involved in the uptake and trafficking of host cytoplasm to the digestive vacuole. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14714922193005
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http://dx.doi.org/10.1016/j.pt.2019.03.005DOI Listing
April 2019
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Correction to: Bed nets used to protect against malaria do not last long in a semi-arid area of Ethiopia: a cohort study.

Malar J 2019 Apr 19;18(1):142. Epub 2019 Apr 19.

Centre for International Health, University of Bergen, Bergen, Norway.

Following publication of the original article [1], the author has flagged errors that affect the scientific content of the article. Read More

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http://dx.doi.org/10.1186/s12936-019-2772-4DOI Listing

Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women.

PLoS One 2019 19;14(4):e0215550. Epub 2019 Apr 19.

West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon- Accra, Ghana.

Background: The overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in Ghana.

Methods: Clinical parameters (hemoglobin, liver function biomarker, peripheral malaria parasitemia, and hepatitis B viremia) and cytokine profiles were assayed and compared across four categories of pregnant women: un-infected, mono-infected with Plasmodium falciparum (Malaria group), mono-infected with chronic hepatitis B virus (CHB group) and co-infected (Malaria+CHB group). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215550PLOS

Rapid high throughput SYBR green assay for identifying the malaria vectors Anopheles arabiensis, Anopheles coluzzii and Anopheles gambiae s.s. Giles.

PLoS One 2019 19;14(4):e0215669. Epub 2019 Apr 19.

Vestergaard regional office, Washington DC, United States of America.

The Anopheles gambiae sensu lato species complex consists of a number of cryptic species with different habitats and behaviours. These morphologically indistinct species are identified by chromosome banding. Several molecular diagnostic techniques for distinguishing between An. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215669PLOS
April 2019
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Cyclosporiasis Surveillance - United States, 2011-2015.

MMWR Surveill Summ 2019 04 19;68(3):1-16. Epub 2019 Apr 19.

Division of Parasitic Diseases and Malaria, Center for Global Health, CDC.

Problem/condition: Cyclosporiasis is an intestinal illness caused by the parasite Cyclospora cayetanensis, which is transmissible by ingestion of fecally contaminated food or water. Cyclosporiasis is most common in tropical and subtropical regions of the world. In the United States, foodborne outbreaks of cyclosporiasis have been linked to various types of imported fresh produce (e. Read More

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http://dx.doi.org/10.15585/mmwr.ss6803a1DOI Listing

The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum.

Parasitol Res 2019 Apr 18. Epub 2019 Apr 18.

LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG), Senckenberganlage 25, 60325, Frankfurt, Germany.

Antimicrobial peptides (AMPs) are important components of the vertebrate and invertebrate innate immune systems. Although AMPs are widely recognized for their broad-spectrum activity against bacteria, fungi, and viruses, their activity against protozoan parasites has not been investigated in detail. In this study, we tested 10 AMPs from three different insect species: the greater wax moth Galleria mellonella (cecropin A-D), the fruit fly Drosophila melanogaster (drosocin, Mtk-1 and Mtk-2), and the blow fly Lucilia sericata (LSerPRP-2, LSerPRP-3 and stomoxyn). Read More

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http://dx.doi.org/10.1007/s00436-019-06305-xDOI Listing

Development of B Cell Memory in Malaria.

Front Immunol 2019 2;10:559. Epub 2019 Apr 2.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

A single exposure to many viral and bacterial pathogens typically induces life-long immunity, however, the development of the protective immunity to parasites is strikingly less efficient and achieves only partial protection, with adults residing in endemic areas often experiencing asymptomatic infections. Although naturally acquired immunity to malaria requires both cell-mediated and humoral immune responses, antibodies govern the control of malarial disease caused by the blood-stage form of the parasites. A large body of epidemiological evidence described that antibodies to antigens are inefficiently generated and rapidly lost without continued parasite exposure, suggesting that malaria is accompanied by defects in the development of immunological B cell memory. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00559
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http://dx.doi.org/10.3389/fimmu.2019.00559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454213PMC
April 2019
1 Read

Cytochrome P450 2D6 profiles and their relationship with outcomes of primaquine anti-relapse therapy in Australian Defence Force personnel deployed to Papua New Guinea and East Timor.

Malar J 2019 Apr 18;18(1):140. Epub 2019 Apr 18.

Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD, Australia.

Background: Primaquine, an 8-aminoquinoline with anti-hypnozoite activity against Plasmodium vivax, is metabolized by human cytochrome P450 2D6 (CYP2D6) to its active metabolite. Human CYP2D6 activities may influence the metabolism of primaquine and the risk of experiencing Plasmodium relapses following primaquine anti-relapse therapies (PART). In this study, the CYP2D6 profile and its relationship with outcomes of PART in Australian Defence Force (ADF) personnel is retrospectively investigated. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2774-2DOI Listing
April 2019
1 Read

Long-lasting insecticidal nets and indoor residual spraying may not be sufficient to eliminate malaria in a low malaria incidence area: results from a cluster randomized controlled trial in Ethiopia.

Malar J 2019 Apr 18;18(1):141. Epub 2019 Apr 18.

Centre for International Health, University of Bergen, Bergen, Norway.

Background: Conflicting results exist on the added benefit of combining long-lasting insecticidal nets (LLINs) with indoor residual spraying (IRS) to control malaria infection. The main study objective was to evaluate whether the combined use of LLINs and IRS with propoxur provides additional protection against Plasmodium falciparum and/or Plasmodium vivax among all age groups compared to LLINs or IRS alone.

Methods: This cluster-randomized, controlled trial was conducted in the Rift Valley area of Ethiopia from September 2014 to January 2017 (121 weeks); 44 villages were allocated to each of four study arms: LLIN + IRS, IRS, LLIN, and control. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2775-1DOI Listing
April 2019
1 Read

Identification and characterization of Pv50, a novel Plasmodium vivax merozoite surface protein.

Parasit Vectors 2019 Apr 18;12(1):176. Epub 2019 Apr 18.

Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, Republic of Korea.

Background: Plasmodium vivax contains approximately 5400 coding genes, more than 40% of which code for hypothetical proteins that have not been functionally characterized. In a previous preliminary screening using pooled serum samples, numerous hypothetical proteins were selected from among those that were highly transcribed in the schizont-stage of parasites, and highly antigenic P. vivax candidates including hypothetical proteins were identified. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3434-7DOI Listing
April 2019
4 Reads

Population pharmacokinetics and pharmacodynamics of the artesunate-mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children.

Malar J 2019 Apr 18;18(1):139. Epub 2019 Apr 18.

Drugs for Neglected Diseases initiative, Geneva, Switzerland.

Background: The World Health Organization (WHO) recommends combinations of an artemisinin derivative plus an anti-malarial drug of longer half-life as treatment options for uncomplicated Plasmodium falciparum infections. In Africa, artesunate-mefloquine (ASMQ) is an infrequently used artemisinin-based combination therapy (ACT) because of perceived poor tolerance to mefloquine. However, the WHO has recommended reconsideration of the use of ASMQ in Africa. Read More

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http://dx.doi.org/10.1186/s12936-019-2754-6DOI Listing

Training through malaria research: building capacity in good clinical and laboratory practice in Liberia.

Malar J 2019 Apr 17;18(1):136. Epub 2019 Apr 17.

ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Background: Limited health research capacities (HRC) undermine a country's ability to identify and adequately respond to local health needs. Although numerous interventions to strengthen HRC have been conducted in Africa, there is a need to share the lessons learnt by funding organizations, institutes and researchers. The aim of this report is to identify best practices in HRC strengthening by describing a training programme conducted between 2016 and 2017 at the Saint Joseph's Catholic Hospital (SJCH) in Monrovia (Liberia). Read More

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http://dx.doi.org/10.1186/s12936-019-2767-1DOI Listing

Invasive Salmonella infections among children in Bintulu, Sarawak, Malaysian Borneo: a 6-year retrospective review.

BMC Infect Dis 2019 Apr 18;19(1):330. Epub 2019 Apr 18.

Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.

Background: Invasive Salmonella infections result in significant morbidity and mortality in developing countries. In Asia, typhoid and paratyphoid fever are reported to be the major invasive Salmonella infections, while invasive non-typhoidal Salmonella (iNTS) infections are believed to be uncommon. Data from Sarawak, in Malaysian Borneo, are limited. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3963-xDOI Listing
April 2019
1 Read

Genetic diversity of zoonotic malaria parasites from mosquito vector and vertebrate hosts.

Infect Genet Evol 2019 Apr 15;73:26-32. Epub 2019 Apr 15.

Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:

We explored and constructed haplotype network for simian malaria species: Plasmodium knowlesi, P. cynomolgi and P. inui aiming to understand the transmission dynamics between mosquitoes, humans and macaques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15671348193005
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http://dx.doi.org/10.1016/j.meegid.2019.04.010DOI Listing
April 2019
3 Reads

The effects of larval organic fertiliser exposure on the larval development, adult longevity and insecticide tolerance of zoophilic members of the Anopheles gambiae complex (Diptera: Culicidae).

PLoS One 2019 18;14(4):e0215552. Epub 2019 Apr 18.

Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.

Zoophilic members of the Anopheles gambiae complex are often associated with cattle. As such, it is likely that the immature aquatic stages will be exposed to cattle faeces as a pollutant. This study aimed to examine the effect of cattle manure on members of the An. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215552PLOS

Larvicidal activity of extract against mosquitoes.

J Vector Borne Dis 2018 Oct-Dec;55(4):282-290

World Health Organization, SEARO, New Delhi, India.

Background & Objectives: Vector control strategies play significant role in reducing the transmission of malaria, dengue and other vector-borne diseases. The control of vector population using synthetic insecticides has resulted in development of insecticide resistance and negative effects on humans and environment. The present investigation evaluated the larvicidal potential of methanol, dichloromethane and hexane extracts of leaves and seeds of Ricinus communis (castor) plant against the early IV instar larvae of the dengue vector, Aedes aegypti, and malaria vector, Anopheles culicifacies. Read More

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http://dx.doi.org/10.4103/0972-9062.256563DOI Listing
April 2019
2 Reads

Genetic diversity and structural analysis of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (IspE) from .

J Vector Borne Dis 2018 Oct-Dec;55(4):271-281

Protein Biochemistry and Structural Biology Laboratory, ICMR-National Institute of Malaria Research, New Delhi, India.

Background & Objectives: Plasmodium parasite harbours unique methylerythritol phosphate (MEP) pathway which is obligatory for the biosynthesis of isoprenoids. In malaria parasites, the isoprenoids are indispensable during hepatic, erythrocytic and gametocytic stages. Owing to the criticality of MEP pathway and the potential of its enzymes to act as antimalarial drug target, this study comprehensively investigated the genetic diversity and structural composition of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (IspE), fourth enzyme of MEP pathway in Indian Plasmodium falciparum (PfIspE). Read More

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http://dx.doi.org/10.4103/0972-9062.256562DOI Listing
April 2019
1 Read

Strengthening of vector control in South-East Asia: Outcomes from a WHO regional workshop.

J Vector Borne Dis 2018 Oct-Dec;55(4):247-257

Department of Communicable Diseases, World Health Organization, South-East Asia Regional Office, New Delhi, India.

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http://dx.doi.org/10.4103/0972-9062.256559DOI Listing
April 2019
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Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide.

Sci Rep 2019 Apr 17;9(1):6203. Epub 2019 Apr 17.

Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States.

Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease burden areas. However, diagnosing bacteremia is challenging for clinicians, especially in children presenting with co-infections such as malaria and HIV. Read More

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http://dx.doi.org/10.1038/s41598-019-42502-5DOI Listing
April 2019
1 Read

Astronaut twins, Nepal tornado and malaria vaccine.

Authors:

Nature 2019 Apr;568(7752):280-281

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http://www.nature.com/articles/d41586-019-01165-y
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http://dx.doi.org/10.1038/d41586-019-01165-yDOI Listing
April 2019
1 Read

Hospital-derived antibody profiles of malaria patients in Southwest India.

Malar J 2019 Apr 17;18(1):138. Epub 2019 Apr 17.

Department of Chemistry and Department of Global Health, University of Washington, Seattle, WA, 98195, USA.

Background: Naturally acquired immunity to malaria across the globe varies in intensity and protective powers. Many of the studies on immunity are from hyperendemic regions of Africa. In Asia, particularly in India, there are unique opportunities for exploring and understanding malaria immunity relative to host age, co-occurrence of Plasmodium falciparum and Plasmodium vivax infections, varying travel history, and varying disease severity. Read More

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http://dx.doi.org/10.1186/s12936-019-2771-5DOI Listing

Systematic Review of Important Bacterial Zoonoses in Africa in the Last Decade in Light of the 'One Health' Concept.

Pathogens 2019 04 16;8(2). Epub 2019 Apr 16.

Infectious Diseases and Anti-Infective Therapy Research Group, Sharjah Medical Research Institute and College of Pharmacy, University of Sharjah, Sharjah 27272, UAE.

Zoonoses present a major public health threat and are estimated to account for a substantial part of the infectious disease burden in low-income countries. The severity of zoonotic diseases is compounded by factors such as poverty, living in close contact with livestock and wildlife, immunosuppression as well as coinfection with other diseases. The interconnections between humans, animals and the environment are essential to understand the spread and subsequent containment of zoonoses. Read More

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http://dx.doi.org/10.3390/pathogens8020050DOI Listing
April 2019
3 Reads

Effects of Socio-Environmental Factors on Malaria Infection in Pakistan: A Bayesian Spatial Analysis.

Int J Environ Res Public Health 2019 Apr 16;16(8). Epub 2019 Apr 16.

School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.

The role of socio-environmental factors in shaping malaria dynamics is complex and inconsistent. Effects of socio-environmental factors on malaria in Pakistan at district level were examined. Annual malaria cases data were obtained from Directorate of Malaria Control Program, Pakistan. Read More

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http://dx.doi.org/10.3390/ijerph16081365DOI Listing

The Importance of Iron Status for Young Children in Low- and Middle-Income Countries: A Narrative Review.

Pharmaceuticals (Basel) 2019 Apr 16;12(2). Epub 2019 Apr 16.

Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Sciences and Technology, ETH Zürich, CH-8092 Zürich, Switzerland.

Early childhood is characterised by high physiological iron demand to support processes including blood volume expansion, brain development and tissue growth. Iron is also required for other essential functions including the generation of effective immune responses. Adequate iron status is therefore a prerequisite for optimal child development, yet nutritional iron deficiency and inflammation-related iron restriction are widespread amongst young children in low- and middle-income countries (LMICs), meaning iron demands are frequently not met. Read More

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https://www.mdpi.com/1424-8247/12/2/59
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http://dx.doi.org/10.3390/ph12020059DOI Listing
April 2019
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Geographic expansion of artemisinin resistance.

J Travel Med 2019 Apr 17. Epub 2019 Apr 17.

Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Background: Artemisinin-based combination therapy (ACT) is the global standard of care for uncomplicated falciparum malaria. First reports of ACT resistance came from western Cambodia and the Thailand-Cambodia border in 2002-2004. The subsequent emergence and expansion of P. Read More

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http://dx.doi.org/10.1093/jtm/taz030DOI Listing

Malaria Standby Emergency Treatment (SBET) for Travelers Visiting Malaria Endemic Areas: a Systematic Review and Meta-Analysis.

J Travel Med 2019 Apr 17. Epub 2019 Apr 17.

Department of research, innovation and training, Unisanté, Center for Primary Care and Public Health, University of Lausanne, Switzerland.

Malaria prevention methods for travelers to low or moderate malaria risk areas varies and remains controversial. Standby Emergency Treatment (SBET) for malaria is one possible strategy increasingly recommended since 1988 with little evidence on its effectiveness or how it is truly being used. A systematic review and meta-analysis were performed based on a structured search in Embase, Medline, PubMed, Cochrane, and Web of Science on September 7, 2018. Read More

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http://dx.doi.org/10.1093/jtm/taz027DOI Listing

Cerebral inducible nitric oxide synthase protein expression in microglia, astrocytes and neurons in Trypanosoma brucei brucei-infected rats.

PLoS One 2019 17;14(4):e0215070. Epub 2019 Apr 17.

Malaria Research Unit, UMR 5246 CNRS, Claude-Bernard Lyon-1 University, Villeurbanne, France.

To study the anatomo-biochemical substrates of brain inflammatory processes, Wistar male rats were infected with Trypanosoma brucei brucei. With this reproducible animal model of human African trypanosomiasis, brain cells (astrocytes, microglial cells, neurons) expressing the inducible nitric oxide synthase (iNOS) enzyme were revealed. Immunohistochemistry was achieved for each control and infected animal through eight coronal brain sections taken along the caudorostral axis of the brain (brainstem, cerebellum, diencephalon and telencephalon). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215070PLOS

Assessing the causes of under-five mortality and proportion associated with pneumococcal diseases in Cameroon. A case-finding retrospective observational study: 2006-2012.

PLoS One 2019 17;14(4):e0212939. Epub 2019 Apr 17.

Mother & Child Centre (MCH), Chantal Biya Foundation, Yaoundé, Cameroon.

Background: Vital registration data outlining causes of deaths (CoD) are important for a sustainable health system, targeted interventions and other relevant policies. There is data paucity on vital registration systems in developing countries. We assessed the leading causes and proportions of under-five deaths, and particularly those related to pneumococcal infections in Yaoundé, Cameroon, using hospital registration data. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212939PLOS

Host Selection of Field-Collected and in Bangladesh.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh.

and appear to play an important role in contemporary malaria transmission in Bangladesh. However, very little is known about the natural host selection of these vectors. Therefore, host selection of these two species was investigated in Bandarban, the most malarious region of Bangladesh. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0923
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http://dx.doi.org/10.4269/ajtmh.18-0923DOI Listing
April 2019
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Development and Initial Validation of a Frontline Health Worker mHealth Assessment Platform (MEDSINC) for Children 2-60 Months of Age.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

THINKMD, Inc., Burlington, Vermont.

Approximately 3 million children younger than 5 years living in low- and middle-income countries (LMICs) die each year from treatable clinical conditions such as pneumonia, dehydration secondary to diarrhea, and malaria. A majority of these deaths could be prevented with early clinical assessments and appropriate therapeutic intervention. In this study, we describe the development and initial validation testing of a mobile health (mHealth) platform, MEDSINC, designed for frontline health workers (FLWs) to perform clinical risk assessments of children aged 2-60 months. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0869
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http://dx.doi.org/10.4269/ajtmh.18-0869DOI Listing
April 2019
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2.699 Impact Factor

The Investment Case for Malaria Elimination in Thailand: A Cost-Benefit Analysis.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

RTI International, Washington, District of Columbia.

After a dramatic decline in the annual malaria incidence in Thailand since 2000, the Thai government developed a National Malaria Elimination Strategy (NMES) to end local malaria transmission by 2024. This study examines the expected costs and benefits of funding the NMES (elimination scenario) versus not funding malaria elimination programming (resurgence scenario) from 2017 to 2036. Two case projection approaches were used to measure the number of malaria cases over the study period, combined with a set of Thailand-specific economic assumptions, to evaluate the cost of a malaria case and to quantify the cost-benefit ratio. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0897DOI Listing

Infection as a Predictor of Low Aerobic Capacity in Ugandan Children.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Using the 20-meter shuttle run test (20mSRT) as a morbidity metric, we assessed whether infection was associated with decreased aerobic capacity in Ugandan children across a range of altitudes, either at low (∼600 m) or high (∼1,000 m) altitudes. A total of 305 children were recruited from six schools within the Buliisa District, Lake Albert, Uganda. A subset ( = 96) of these had been previously assessed and treated for schistosomiasis ± malaria 2 weeks prior. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0922
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http://dx.doi.org/10.4269/ajtmh.18-0922DOI Listing
April 2019
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A Direct from Blood/Plasma Reverse Transcription-Polymerase Chain Reaction for Dengue Virus Detection in Point-of-Care Settings.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada.

Infection with dengue virus (DENV) is widespread across tropical regions and can result in severe disease. Early diagnosis is important both for patient management and to differentiate infections that present with similar symptoms, such as malaria, chikungunya, and Zika. Rapid diagnostic tests that are used presently for point-of-care detection of DENV antigens lack the sensitivity of molecular diagnostics that detect viral RNA. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0138DOI Listing