90,399 results match your criteria Malaria


Iron Status of Kenyan Pregnant Women after Adjusting for Inflammation Using BRINDA Regression Analysis and Other Correction Methods.

Nutrients 2019 Feb 16;11(2). Epub 2019 Feb 16.

Danone Nutricia Research, route de la Vauve, 91120 Palaiseau, France.

Serum ferritin concentration is the preferred biomarker to assess population iron status in the absence of inflammation. Interpretation of this biomarker is complicated in populations with a high burden of infection, however, because inflammation increases serum ferritin concentration independently of iron status. We aimed to compare estimates of iron status of Kenyan pregnant women, with circulating ferritin concentrations adjusted for inflammation using newly proposed methods by the BRINDA project, or using previously proposed adjustment methods. Read More

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http://dx.doi.org/10.3390/nu11020420DOI Listing
February 2019

Spatial and temporal development of deltamethrin resistance in malaria vectors of the Anopheles gambiae complex from North Cameroon.

PLoS One 2019 19;14(2):e0212024. Epub 2019 Feb 19.

Institut de Recherche de Yaoundé (IRY), Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon.

The effectiveness of insecticide-based malaria vector control interventions in Africa is threatened by the spread and intensification of pyrethroid resistance in targeted mosquito populations. The present study aimed at investigating the temporal and spatial dynamics of deltamethrin resistance in An. gambiae s. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212024PLOS
February 2019

Prevalence of Portable Point of Care Tests Used on Medical Service Trips in Latin America and the Caribbean.

Ann Glob Health 2018 Nov 5;84(4):736-742. Epub 2018 Nov 5.

Toronto Rehabilitation Institute, University Health Network, CA.

Background: Short-term, primary care medical service trips (MSTs) frequently use inexpensive, portable point of care (POC) tests to guide diagnosis and treatment of patients in low-resource settings. However, the degree to which different POC tests are carried by organizations serving remote communities is currently unknown.

Objective: The aim of this study was to determine the prevalence of various POC tests used by MST-sending organizations operating in Latin America. Read More

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http://dx.doi.org/10.9204/aogh.2385DOI Listing
November 2018

Cost Effectiveness of Mobile Health for Antenatal Care and Facility Births in Nigeria.

Ann Glob Health 2018 Nov 5;84(4):592-602. Epub 2018 Nov 5.

Pathfinder International, US.

Background: The use of mobile technology in the health sector, often referred to as mHealth, is an innovation that is being used in countries to improve health outcomes and increase and improve both the demand and supply of health care services. This study assesses the actual cost-effectiveness of initiating and implementing the use of the mHealth as a supply side job aid for antenatal care. The study also estimates the cost-effectiveness ratio if mHealth was also used to encourage and track women through facility delivery. Read More

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http://dx.doi.org/10.9204/aogh.2364DOI Listing
November 2018

Insecticide susceptibility status and major detoxifying enzymes activity in Anopheles subpictus from Kasur, Pakistan.

Med Vet Entomol 2019 Feb 18. Epub 2019 Feb 18.

Department of Statistics, The Women University, Multan, Pakistan.

Anopheles subpictus s.l. Grassi (Diptera: Culicidae) is a malaria vector in South Asia, where insecticides are the mainstay for vector control interventions. Read More

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http://dx.doi.org/10.1111/mve.12367DOI Listing
February 2019

Characterization of Plasmodium ovale spp. imported from Africa to Henan Province, China.

Sci Rep 2019 Feb 18;9(1):2191. Epub 2019 Feb 18.

Department of Parasite Disease Control and Prevention, Henan Province Center for Disease Control and Prevention, Zhengzhou, 450016, P. R. China.

As indigenous malaria has decreased over recent decades, the increasing number of imported malaria cases has provided a new challenge for China. The proportion of imported cases due to Plasmodium ovale has increased during this time, and the difference between P. ovale curtisi and P. Read More

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http://dx.doi.org/10.1038/s41598-019-38629-0DOI Listing
February 2019

Geographical heterogeneity in prevalence of subclinical malaria infections at sentinel endemic sites of Myanmar.

Parasit Vectors 2019 Feb 18;12(1):83. Epub 2019 Feb 18.

Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, 110122, Liaoning, China.

Background: The malaria burden of Myanmar still remains high within the Greater Mekong Subregion of Southeast Asia. An important indicator of progress towards malaria elimination is the prevalence of parasite infections in endemic populations. Information about malaria epidemiology is mostly derived from reports of confirmed acute malaria cases through passive case detection, whereas the prevalence of baseline subclinical malaria infections is much less known. Read More

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http://dx.doi.org/10.1186/s13071-019-3330-1DOI Listing
February 2019

Community perspectives on treating asymptomatic infections for malaria elimination in The Gambia.

Malar J 2019 Feb 18;18(1):39. Epub 2019 Feb 18.

Medical Anthropology Unit, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Innovative and cost-effective strategies that clear asymptomatic malaria infections are required to reach malaria elimination goals, but remain a challenge. This mixed methods study explored people's attitudes towards the reactive treatment of compound contacts of malaria cases with a 3-day course of dihydroartemisinin-piperaquine (DHAP), the socio-cultural representations of asymptomatic infections, and more specifically their treatment.

Methods: Prior to the start of the intervention, a sequential mixed method study was carried out. Read More

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http://dx.doi.org/10.1186/s12936-019-2672-7DOI Listing
February 2019

Relationship between weight status and anti-malarial drug efficacy and safety in children in Mali.

Malar J 2019 Feb 18;18(1):40. Epub 2019 Feb 18.

Malaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), Bamako, Mali.

Background: Anti-malarial treatments effectiveness remains a critical challenge for control programmes. However, when drug efficacy is established, the dose is calculated based on a predefined weight according to the patient age. Based on the hypothesis that the standard assumption of weight according to the age when administering the drug could lead to a therapeutic failure potentially due to under-dosing (in the case of overweight) or over-dosing (in case of underweight). Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2673-6DOI Listing
February 2019
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Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase.

Eur J Med Chem 2019 Feb 8;167:357-366. Epub 2019 Feb 8.

Laboratório de Cristalografia de Proteínas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, 14040-903, Brazil. Electronic address:

Schistosomiasis ranks second only to malaria as the most common parasitic disease worldwide. 700 million people are at risk and 240 million are already infected. Praziquantel is the anthelmintic of choice but decreasing efficacy has already been documented. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.018DOI Listing
February 2019

Amorphous nanoparticles by self-assembly: processing for controlled release of hydrophobic molecules.

Soft Matter 2019 Feb 18. Epub 2019 Feb 18.

Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, USA.

More than 40% of newly developed drug molecules are highly hydrophobic and, thus, suffer from low bioavailability. Kinetically trapping the drug as a nanoparticle in an amorphous state enhances solubility. However, enhanced solubility can be compromised by subsequent recrystallization from the amorphous state during drying processes. Read More

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http://dx.doi.org/10.1039/c8sm02418aDOI Listing
February 2019

Patterns and trends of malaria in 25 risk districts of Nepal from 2001 to 2017.

Clin Exp Vaccine Res 2019 Jan 31;8(1):77-85. Epub 2019 Jan 31.

Department of Statistics, Faculty of Science, Kasetsart University, Bangkok, Thailand.

Purpose: Malaria has been one of a major infectious parasitic disease in Nepal. Although the number of cases is gradually getting declined since last decade. Therefore, study aims to identify the trends and spatial patterns of malaria among 25 risk districts of Nepal. Read More

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http://dx.doi.org/10.7774/cevr.2019.8.1.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369122PMC
January 2019

Path analyses of risk factors for linear growth faltering in four prospective cohorts of young children in Ghana, Malawi and Burkina Faso.

BMJ Glob Health 2019 13;4(1):e001155. Epub 2019 Jan 13.

Department of Nutrition, University of California Davis, Davis, California, USA.

Stunting prevalence is an indicator of a country's progress towards United Nations' Sustainable Development Goal 2, which is to end hunger and achieve improved nutrition. Accelerating progress towards reducing stunting requires a deeper understanding of the factors that contribute to linear growth faltering. We conducted path analyses of factors associated with 18-month length-for-age z-score (LAZ) in four prospective cohorts of children who participated in trials conducted as part of the International Lipid-Based Nutrient Supplements Project in Ghana (n=1039), Malawi (n=684 and 1504) and Burkina Faso (n=2619). Read More

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http://dx.doi.org/10.1136/bmjgh-2018-001155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350712PMC
January 2019

Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines.

Front Immunol 2019 1;10:135. Epub 2019 Feb 1.

Institute for Glycomics, Griffith University, Southport, QLD, Australia.

In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adjuvants. Liposomes present an attractive adjuvant/delivery system for antigens. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00135
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http://dx.doi.org/10.3389/fimmu.2019.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367261PMC
February 2019
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Intensive physiotherapy with subsequent community-based rehabilitation: two cases of cerebral malaria in rural areas of Malawi.

J Phys Ther Sci 2019 Jan 29;31(1):112-115. Epub 2019 Jan 29.

Department of Physical Therapy, Faculty of Human Science, Hokkaido Bunkyo University, Japan.

[Purpose] This study aimed to elucidate the effect of intensive physiotherapy and community-based rehabilitation on motor function for patients with cerebral malaria in the rural areas of Malawi. [Participants and Methods] The participants were 10- and 9-year-old children with cerebral malaria. At ages 8 and 6 years, they contracted malaria, and their motor function decreased to Gross Motor Function Classification System level III. Read More

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http://dx.doi.org/10.1589/jpts.31.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348175PMC
January 2019

Protein O- and C-Glycosylation pathways in Toxoplasma gondii and Plasmodium falciparum.

Parasitology 2019 Feb 18:1-12. Epub 2019 Feb 18.

Department of Clinical Biochemistry OE4340,Hannover Medical School,Carl-Neuberg-Strasse 1, 30625 Hannover,Germany.

Apicomplexan parasites are amongst the most prevalent and morbidity-causing pathogens worldwide. They are responsible for severe diseases in humans and livestock and are thus of great public health and economic importance. Until the sequencing of apicomplexan genomes at the beginning of this century, the occurrence of N- and O-glycoproteins in these parasites was much debated. Read More

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http://dx.doi.org/10.1017/S0031182019000040DOI Listing
February 2019

Nutrition and its role in human evolution.

J Intern Med 2019 Feb 17. Epub 2019 Feb 17.

Vice Chancellor and Dean for Agriculture and Life Sciences, Texas A&M AgriLife, College Station, TX, USA.

Our understanding of human evolution has improved rapidly over recent decades, facilitated by large-scale cataloguing of genomic variability amongst both modern and archaic humans. It seems clear that the evolution of the ancestors of chimpanzees and hominins separated 7-9 million years ago with some migration out of Africa by the earlier hominins; Homo sapiens slowly emerged as climate change resulted in drier, less forested African conditions. The African populations expanded and evolved in many different conditions with slow mutation and selection rates in the human genome, but with much more rapid mutation occurring in mitochondrial DNA. Read More

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http://dx.doi.org/10.1111/joim.12878DOI Listing
February 2019

The paramagnetic properties of malaria pigment, hemozoin, yield clues to a low-cost system for its trapping and determination.

Talanta 2019 May 25;197:553-557. Epub 2019 Jan 25.

Service de Chimie Thérapeutique et de Pharmacognosie, Université de Mons (UMONS), Bât. 6, Chemin du Champ de Mars 25, 7000 Mons, Belgium. Electronic address:

The binding of malaria pigment, hemozoin, by a gradient magnetic field has been investigated in a manual trapping column system. Two types of magnetic filling have been tested to produce field gradients: nickel-plated steel wires, wrapped around a steel core, and superparamagnetic microbeads. The latter system allows an efficient trapping (> 80%) of β-hematin (a synthetic pigment with physical and paramagnetic properties analogous to those of hemozoin). Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.090DOI Listing

Leveraging the Medicines for Malaria Venture malaria and pathogen boxes to discover chemical inhibitors of East Coast fever.

Int J Parasitol Drugs Drug Resist 2019 Jan 25;9:80-86. Epub 2019 Jan 25.

International Livestock Research Institute, P. O. Box 30709, Nairobi, Kenya. Electronic address:

Chemotherapy of East Coast fever, a lymphoproliferative cancer-like disease of cattle causing significant economic losses in Africa, is largely dependent on the use of buparvaquone, a drug that was developed in the late 1980's. The disease is caused by the tick-borne protozoan pathogen Theileria parva. Buparvaquone can be used prophylactically and it is also active against tropical theileriosis, caused by the related parasite Theileria annulata. Read More

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http://dx.doi.org/10.1016/j.ijpddr.2019.01.002DOI Listing
January 2019
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Acute and sub-acute toxicity of the aqueous extract from the stem bark of Tetrapleura tetrapteura Taub. (Fabaceae) in mice and rats.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

H.E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Biochemistry, Dr. Panjwani Center for Molecular Medicine and Drug Research (P.C.M.D.), International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address:

Ethnopharmacological Relevance: Tetrapleura tetrapteura Taub. is a leguminous multipurpose tree (Fabaceae) indigenous to tropical Africa. Fruits, seeds and stem bark infusions or decoctions of Tetrapleura tetrapteura Taub. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.026DOI Listing
February 2019

Mozambique's Community Antiretroviral Therapy Support Group Program: The Role of Social Relationships in Facilitating HIV/AIDS Treatment Retention.

AIDS Behav 2019 Feb 15. Epub 2019 Feb 15.

The Lewis Family Foundation, Boston, MA, USA.

The Community Antiretroviral (ARV) Therapy Support Group (CASG) program aims to address low retention rates in Mozambique's HIV treatment program and the absorptive capacity of the country's health facilities. CASG provides patients with the opportunity to form groups, whose members provide peer support and collect ARV medications on a rotating basis for one another. Based on the promising results in one province, a multi-site level evaluation followed. Read More

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http://dx.doi.org/10.1007/s10461-019-02419-6DOI Listing
February 2019
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Reverse immunodynamics: a new method for identifying targets of protective immunity.

Sci Rep 2019 Feb 15;9(1):2164. Epub 2019 Feb 15.

Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK.

Despite a dramatic increase in our ability to catalogue variation among pathogen genomes, we have made far fewer advances in using this information to identify targets of protective immunity. Epidemiological models predict that strong immune selection can cause antigenic variants to structure into genetically discordant sets of antigenic types (e.g. Read More

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http://dx.doi.org/10.1038/s41598-018-37288-xDOI Listing
February 2019

Diagnostic performance of CellaVision DM96 for Plasmodium vivax and Plasmodium falciparum screening in peripheral blood smears.

Acta Trop 2019 Feb 12;193:7-11. Epub 2019 Feb 12.

Department of Laboratory Medicine, Korea University College of Medicine, Seoul, South Korea. Electronic address:

Microscopic examination of blood smears is the standard method for malaria diagnosis but is labor-intensive and requires expert staff. CellaVision DM96 (CellaVision, Lund, Sweden) is a digital hematology analyzer available for advanced morphological analysis of blood films including intracellular parasites. Here, we evaluated the CellaVision DM96 Advanced RBC Application for malaria detection in stained peripheral blood (PB) smears. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183084
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http://dx.doi.org/10.1016/j.actatropica.2019.02.009DOI Listing
February 2019
3 Reads

Structured mathematical models to investigate the interactions between Plasmodium falciparum malaria parasites and host immune response.

Math Biosci 2019 Feb 12. Epub 2019 Feb 12.

Department of Mathematics, Millersville University of Pennsylvania, Millersville, PA 17551, USA. Electronic address:

Malaria infection has posed a major health threat for hundreds of years in human history. Yet, due to the complex interactions between a host immune response and the parasite, no sophisticated mathematical models exist to study its dynamics. In this work, we propose a new system of structured partial differential equations that account for the dependence of red blood cell infectivity on maturation level. Read More

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http://dx.doi.org/10.1016/j.mbs.2019.02.005DOI Listing
February 2019

Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria.

PLoS Negl Trop Dis 2019 Feb 15;13(2):e0006987. Epub 2019 Feb 15.

Department of Medical Biology, University of Melbourne, Melbourne, Australia.

Background: The Plasmodium vivax Duffy Binding Protein (PvDBP) is a key target of naturally acquired immunity. However, region II of PvDBP, which contains the receptor-binding site, is highly polymorphic. The natural acquisition of antibodies to different variants of PvDBP region II (PvDBPII), including the AH, O, P and Sal1 alleles, the central region III-V (PvDBPIII-V), and P. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006987DOI Listing
February 2019

The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial.

PLoS Med 2019 Feb 15;16(2):e1002745. Epub 2019 Feb 15.

Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Background: The emergence and spread of multidrug-resistant Plasmodium falciparum in the Greater Mekong Subregion (GMS) threatens global malaria elimination efforts. Mass drug administration (MDA), the presumptive antimalarial treatment of an entire population to clear the subclinical parasite reservoir, is a strategy to accelerate malaria elimination. We report a cluster randomised trial to assess the effectiveness of dihydroartemisinin-piperaquine (DP) MDA in reducing falciparum malaria incidence and prevalence in 16 remote village populations in Myanmar, Vietnam, Cambodia, and the Lao People's Democratic Republic, where artemisinin resistance is prevalent. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002745DOI Listing
February 2019

Trichomonas vaginalis virus (TVV) among women with trichomoniasis and associations with demographics, clinical outcomes, and metronidazole resistance.

Clin Infect Dis 2019 Feb 15. Epub 2019 Feb 15.

Division of Infectious Diseases, University of Alabama at Birmingham.

Background: Trichomonas vaginalis virus (TVV) is a non-segmented, 4.5-5.5 kbp, double-stranded RNA virus infecting T. Read More

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http://dx.doi.org/10.1093/cid/ciz146DOI Listing
February 2019

Updating the modified Thompson test by using whole-body bioluminescence imaging to replace traditional efficacy testing in experimental models of murine malaria.

Malar J 2019 Feb 15;18(1):38. Epub 2019 Feb 15.

Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.

Background: Rodent malaria models are extensively used to predict treatment outcomes in human infections. There is a constant need to improve and refine these models by innovating ways to apply new scientific findings and cutting edge technologies. In addition, and in accordance with the three R's of animal use in research, in vivo studies should be constantly refined to avoid unnecessary pain and distress to the experimental animals by using preemptive euthanasia as soon as the main scientific study objective has been accomplished. Read More

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http://dx.doi.org/10.1186/s12936-019-2661-xDOI Listing
February 2019
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Cytoplasmic and periplasmic expression of recombinant shark VNAR antibody in Escherichia coli.

Prep Biochem Biotechnol 2019 Feb 15:1-13. Epub 2019 Feb 15.

b Clinical Tropical Medicine Department, QIMR Berghofer Medical Research Institute , Brisbane , Australia.

Shark variable new antigen receptors (VNARs) are known to possess excellent heat-stability, and the long complementarity determining region 3 (CDR3) has permitted it to penetrate into the cleft region of antigens. The number of cysteine (Cys) residues contained within VNAR is greater than in conventional antibodies, entailing disulfide bond formation in both the inter- or intra-loop regions is required for interactions with the target protein antigens. Therefore, the selection of a suitable expression system is important to ensure the solubility and correct folding of functional VNAR protein production. Read More

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http://dx.doi.org/10.1080/10826068.2019.1566145DOI Listing
February 2019
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Preconceptional factors associated with hemoglobin concentration in early pregnancy: a community-based cohort study in rural northeastern Tanzania.

Trop Med Int Health 2019 Feb 15. Epub 2019 Feb 15.

Division of Global Health, Department of Public Health, University of Copenhagen, Denmark.

Objective: Maternal anemia in early pregnancy is associated with poor pregnancy outcomes. Furthermore, preconceptional health can influence the health during pregnancy. The aim of this study was to investigate which preconceptional factors were associated with Hb concentration in early pregnancy. Read More

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http://dx.doi.org/10.1111/tmi.13219DOI Listing
February 2019
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Drug-related teratogenic and pathologic causes of birth defects in a tertiary hospital in Southwestern Nigeria.

Pharmacol Res Perspect 2019 Feb 6;7(1):e00452. Epub 2019 Feb 6.

Department of Pharmacology College of Medicine Lagos State University Lagos Nigeria.

Birth defects are important causes of neonatal morbidity and mortality. A good understanding of the etiology is a vital step toward developing improved treatment and preventive strategies. We conducted an audit of medical records of newborns with birth abnormalities in a tertiary hospital over a 10-year period, using a Pro forma designed to collect information on obstetric history, antenatal history, sociodemographics of parents, and the type of birth abnormality. Read More

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http://dx.doi.org/10.1002/prp2.452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364330PMC
February 2019

Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine.

Curr Ther Res Clin Exp 2019 12;90:9-15. Epub 2019 Jan 12.

Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology University of Copenhagen and Department of Clinical Microbiology and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.

Background: There is limited information on the safety or efficacy of currently recommended antimalarial drugs in patients with sickle cell disease (SCD), a population predisposed to worse outcomes if affected by acute malaria. Artesunate-amodiaquine (ASAQ) is the first-line treatment for uncomplicated malaria (UM) in many malaria-endemic countries and is also used for treatment of UM in SCD patients. There is, however, no information to date, on the pharmacokinetics (PK) of amodiaquine or artesunate or the metabolites of these drugs in SCD patients. Read More

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http://dx.doi.org/10.1016/j.curtheres.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360331PMC
January 2019

Integrated approach to malaria prevention at household level in rural communities in Wakiso district, Uganda: impact evaluation of a pilot project.

Afr Health Sci 2018 Dec;18(4):1144-1156

School of Sciences, Nkumba University, Entebbe, Uganda.

Background: The integrated approach to malaria prevention, which advocates for the use of several malaria prevention methods at households, is being explored to complement other existing strategies. We implemented a pilot project that promoted the integrated approach to malaria prevention in two rural communities in Wakiso district, Uganda.

Objectives: This paper presents the impact evaluation findings of the project carried out 2 years after implementation with a focus on changes in knowledge and practices on malaria prevention. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354846PMC
December 2018

Different Life Cycle Stages of Induce Contrasting Responses in Dendritic Cells.

Front Immunol 2019 31;10:32. Epub 2019 Jan 31.

Burnet Institute, Melbourne, VIC, Australia.

Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition of immunity and the efficacy of vaccines. Understanding how dendritic cells are affected by blood-stage parasites will help to understand how immunity is acquired and maintained, and how vaccine responses may be impacted by malaria infection or exposure. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00032
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http://dx.doi.org/10.3389/fimmu.2019.00032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365426PMC
January 2019
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People from Ibiza: an unexpected isolate in the Western Mediterranean.

Eur J Hum Genet 2019 Feb 14. Epub 2019 Feb 14.

Departament de Ciències Experimentals i de la Salut, Institute of Evolutionary Biology (CSIC-UPF), Universitat Pompeu Fabra, Barcelona, Spain.

In this study, we seek to understand and to correlate the genetic patterns observed in the population of the island of Ibiza in the Western Mediterranean basin with past events. Genome-wide genotypes of 189 samples representing 13 of 17 regions in Spain have been analyzed, in addition to 105 samples from the Levant, 157 samples from North Africa, and one ancient sample from the Phoenician Cas Molí site in Ibiza. Before the Catalans conquered the island in 1235 CE, Ibiza (Eivissa) had already been influenced by several cultures, starting with the Phoenicians, then the Carthaginians, followed by the Umayyads. Read More

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http://dx.doi.org/10.1038/s41431-019-0361-1DOI Listing
February 2019

Juvenile hormone controls ovarian development in female Anopheles albimanus mosquitoes.

Sci Rep 2019 Feb 14;9(1):2127. Epub 2019 Feb 14.

Department of Biological Sciences and Biomolecular Science Institute, Florida International University, Miami, FL, USA.

Anophelinae mosquitoes are vectors of human malaria, a disease that infects hundreds of millions of people and causes almost 600,000 fatalities annually. Despite their medical importance, laboratory studies on key aspects of Anophelinae reproductive biology have been limited, and in particular, relatively little is known about the role of juvenile hormone (JH) in the control of female reproduction. The study presented here attempts to fill a gap of knowledge in our understanding of the JH control of ovarian development in female Anophelinae mosquitoes, using Anopheles albimanus as a model. Read More

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http://dx.doi.org/10.1038/s41598-019-38631-6DOI Listing
February 2019

Efficacy of Nutrition and WASH/Malaria Educational Community-Based Interventions in Reducing Anemia in Preschool Children from Bengo, Angola: Study Protocol of a Randomized Controlled Trial.

Int J Environ Res Public Health 2019 Feb 5;16(3). Epub 2019 Feb 5.

Health Research Center of Angola (CISA), Caxito, Estação Central de Luanda, Apartado IV n°5547, Luanda, Angola.

Angola reports one of the highest infant mortality rates in the world, and anemia represents one of its important causes. Recent studies, in under-five children from the Bengo province of Angola, described high prevalence's, suggesting malaria, undernutrition and urogenital schistosomiasis as important contributors for the occurrence and spatial variations of anemia. Educational community-based interventions, either in Nutrition and Water, Sanitation, Hygiene and Malaria are recommended to correct anemia. Read More

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http://dx.doi.org/10.3390/ijerph16030466DOI Listing
February 2019

T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes.

J Neuroimmunol 2019 Feb 7;330:5-11. Epub 2019 Feb 7.

Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, USA.

Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.02.002DOI Listing
February 2019
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Plasmodium ovale curtisi and Plasmodium ovale wallikeri in Chinese travelers: Prevalence of novel genotypes of circumsporozoite protein in the African continent.

Infect Genet Evol 2019 Feb 11. Epub 2019 Feb 11.

Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea. Electronic address:

Imported malaria due to Plasmodium ovale curtisi and P. ovale wallikeri infections from African countries has increased recently (2011-2014) in Chinese travelers. We report novel genotypes, their prevalence and the predominant haplotypes of P. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.02.008DOI Listing
February 2019

The Amaryllidaceae as a source of antiplasmodial crinane alkaloid constituents.

Fitoterapia 2019 Feb 11. Epub 2019 Feb 11.

Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa. Electronic address:

Malaria is prevalent in tropical and subtropical regions of the globe. With over 200 million cases reported annually, particularly in sub-Saharan Africa, it is an unnecessary burden to already overworked and ailing healthcare structures. Traditional medicine (TM) remains vibrant in most of these regions wherein plants often serve as the first line of defense against malaria. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.009DOI Listing
February 2019

In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

J Ethnopharmacol 2019 Feb 11. Epub 2019 Feb 11.

Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610, Antwerp, Belgium.

Ethnopharmacological Relevance: An aqueous decoction of root bark of Alstonia congensis Engl. (Apocynaceae) is used in several African countries to treat various ailments including malaria.

Materials And Methods: Extracts of different polarity and isolated constituents were tested in vitro for their antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 and the chloroquine-sensitive strain P. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.019DOI Listing
February 2019

Ultra-low-density Plasmodium falciparum infections in African settings.

Clin Infect Dis 2019 Feb 15. Epub 2019 Feb 15.

Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control & MRC Collaborating Centre for Malaria Research, University of Pretoria, Private Bag x20, Hatfield, Pretoria, South Africa.

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http://dx.doi.org/10.1093/cid/ciz147DOI Listing
February 2019

Significance of Autophagy in Dengue Virus Infection: A Brief Review.

Am J Trop Med Hyg 2019 Feb 11. Epub 2019 Feb 11.

Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Thailand.

Dengue virus (DENV) causes asymptomatic to severe life-threatening infections and affects millions of people worldwide. Autophagy, a cellular degradative pathway, has both proviral and antiviral functions. Dengue virus triggers the autophagy pathway for the successful replication of its genome. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0761DOI Listing
February 2019

Proteome data of salivary glands using high-resolution mass spectrometry analysis.

Data Brief 2018 Dec 27;21:2554-2561. Epub 2018 Nov 27.

ICMR-National Institute of Malaria Research, Field Unit, Campal, Panaji, Goa 403001, India.

The data article reports data of the proteins expressed in female salivary glands. Proteomic data were acquired using high-resolution mass spectrometers - Orbitrap-Velos and Orbitrap-Elite. Samples derived from adult female salivary glands led to the identification of 4390 proteins. Read More

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http://dx.doi.org/10.1016/j.dib.2018.11.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288417PMC
December 2018

Plasmodium palmitoylation machinery engineered in for high-throughput screening of palmitoyl acyl-transferase inhibitors.

FEBS Open Bio 2019 Feb 10;9(2):248-264. Epub 2019 Jan 10.

Special Centre for Molecular Medicine Jawaharlal Nehru University New Delhi India.

Lipid-based palmitoylation is a post-translation modification (PTM) which acts as a biological rheostat in life cycle progression of a deadly human malaria parasite, . palmitoylation is catalyzed by 12 putative palmitoyl acyl-transferase enzymes containing the conserved DHHC-CRD (DHHC motif within a cysteine-rich domain) which can serve as a druggable target. However, the paucity of high-throughput assays has impeded the design of drugs targeting palmitoylation. Read More

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http://dx.doi.org/10.1002/2211-5463.12564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356172PMC
February 2019

Brain Endothelium: The "Innate Immunity Response Hypothesis" in Cerebral Malaria Pathogenesis.

Front Immunol 2018 29;9:3100. Epub 2019 Jan 29.

Instituto Gulbenkian de Ciência, Oeiras, Portugal.

Cerebral malaria (CM) is a life-threatening neurological syndrome caused by infection afflicting mainly children in Africa. Current pathogenesis models implicate parasite and host-derived factors in impairing brain vascular endothelium (BVE) integrity. Sequestration of -infected red blood cells (iRBCs) in brain microvessels is a hallmark of CM pathology. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361776PMC
January 2019

Fetal-Derived MyD88 Signaling Contributes to Poor Pregnancy Outcomes During Gestational Malaria.

Front Microbiol 2019 29;10:68. Epub 2019 Jan 29.

Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.

Placental malaria (PM) remains a severe public health problem in areas of high malaria transmission. Despite the efforts to prevent infection poor outcomes in endemic areas, there is still a considerable number of preterm births and newborns with low birth weight resulting from PM. Although local inflammation triggered in response to malaria is considered crucial in inducing placental damage, little is known about the differential influence of maternal and fetal immune responses to the disease progression. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362412PMC
January 2019

Are malaria elimination efforts on right track? An analysis of gains achieved and challenges ahead.

Authors:
Sunil Dhiman

Infect Dis Poverty 2019 Feb 13;8(1):14. Epub 2019 Feb 13.

Vector Management Division, Defence Research and Development Establishment, Gwalior, Madhya Pradesh, 474002, India.

Background: Malaria causes significant morbidity and mortality each year. In the past few years, the global malaria cases have been declining and many endemic countries are heading towards malaria elimination. Nevertheless, reducing the number of cases seems to be easy than sustained elimination. Read More

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http://dx.doi.org/10.1186/s40249-019-0524-xDOI Listing
February 2019

Prevalence and intensity of Loa loa infection over twenty-three years in three communities of the Mbalmayo health district (Central Cameroon).

BMC Infect Dis 2019 Feb 13;19(1):146. Epub 2019 Feb 13.

Centre for Research on Filariasis and other Tropical Diseases, PO Box 5797, Yaounde, Cameroon.

Background: Loiasis is a vector-borne parasitic disease due to Loa loa and transmitted to humans by tabanids of the genus Chrysops. Loiasis has been historically considered as the second or third most common reason for medical consultation after malaria, and a recent study has reported an excess mortality associated with the infection. However, the clinical impact of this filarial disease is yet to be elucidated, and it is still considered a benign disease eliciting very little attention. Read More

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http://dx.doi.org/10.1186/s12879-019-3776-yDOI Listing
February 2019
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Community health workers trained to conduct verbal autopsies provide better mortality measures than existing surveillance: Results from a cross-sectional study in rural western Uganda.

PLoS One 2019 13;14(2):e0211482. Epub 2019 Feb 13.

Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, United States of America.

Background: In much of sub-Saharan Africa, health facilities serve as the primary source of routine vital statistics. These passive surveillance systems, however, are plagued by infrequent and unreliable reporting and do not capture events that occur outside of the formal health sector. Verbal autopsies (VA) have been utilized to estimate the burden and causes of mortality where civil registration and vital statistics systems are weak, but VAs have not been widely employed in national surveillance systems. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211482PLOS
February 2019