1,112 results match your criteria Malakoplakia

Malakoplakia mimicking a locally advanced colorectal neoplasm.

J Surg Case Rep 2021 Jun 4;2021(6):rjab225. Epub 2021 Jun 4.

Colorectal Surgery Unit, Surgery Service, Complejo Asistencial Doctor Sótero Del Río, Santiago 8207257, Chile.

Malakoplakia is a rare disease. Clinical presentation is non-specific, making its diagnosis an incidental finding on histopathological analysis. The aim of this case report is to describe a patient diagnosed with colon, renal and soft tissue malacoplakia mimicking a locally advanced colorectal cancer. Read More

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Mimicker of malignancy, malakoplakia presenting as PI-RADS 5 lesion in mp-MRI-A case report.

Indian J Cancer 2021 Apr-Jun;58(2):307-309

Department of Urology, Amrita Institute of Medical Sciences and Research Center, Kochi, Kerala, India.

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CT and pathological features in renal parenchymal malakoplakia: a case report and review of the literature.

Yuanfen Yang

Aktuelle Urol 2021 May 18. Epub 2021 May 18.

Departments of Radiology, Xintai people's Hospital, Xintai, China.

Renal malakoplakia is a rare form of chronic inflammatory granulomatous disease in the kidney. It occurs in adult patients with immunocompromised status or debilitating disease. In the present study, we reported a case of a 50-year-old woman with no underlying disease. Read More

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Necrotizing skin and soft tissue infection with malakoplakia-like features mimicking pyoderma gangrenosum.

JAAD Case Rep 2021 Jun 8;12:1-4. Epub 2021 Apr 8.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

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Successful use of azithromycin for Escherichia coli-associated renal allograft malakoplakia: a report of two cases.

Eur J Clin Microbiol Infect Dis 2021 May 14. Epub 2021 May 14.

Department of Infectious Diseases, Austin Health, 145 Studley Road, Heidelberg, Victoria, 3084, Australia.

Malakoplakia is a chronic granulomatous disease associated with incomplete clearance of bacterial pathogens. A multimodal approach to therapy includes antimicrobials with intracellular activity, reduction in immunosuppression, and debulking of lesions. Azithromycin has an intracellular mechanism of action and enhanced Gram-negative activity compared to other macrolides. Read More

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Malakoplakia in the Urinary Bladder of 4 Puppies.

Vet Pathol 2021 Apr 23:3009858211009779. Epub 2021 Apr 23.

311308Purdue University, West Lafayette, IN, USA.

Malakoplakia in humans most often affects the urinary bladder and is characterized by inflammation with von Hansemann-type macrophages, with or without Michaelis-Gutmann bodies, and is frequently associated with infection. We describe the microscopic features of malakoplakia in the urinary bladder of 4 puppies. In all cases, the lamina propria of the urinary bladder was markedly expanded by sheets of large, round to polygonal macrophages with intracytoplasmic, periodic acid-Schiff-positive granules and granular inclusions, and rare Prussian blue-positive inclusions. Read More

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Expression of uroplakin II and GATA-3 in bladder cancer mimickers: caveats in the use of a limited panel to determine cell of origin in bladder lesions.

Hum Pathol 2021 Apr 19;113:28-33. Epub 2021 Apr 19.

Department of Pathology, University of California San Diego, La Jolla, CA, 92093, USA; Department of Pathology, Oregon Health & Science University, Portland, OR, 97239, USA. Electronic address:

Antibodies targeting uroplakin II (UPII) are highly specific for urothelial cells and are frequently used to determine if a primary bladder lesion or a metastatic lesion originates from the urothelium. However, to date, no studies have tested the expression of UPII in histological mimickers of bladder cancer that are nonurothelial in origin. Given the potential risk of misdiagnosis, immunohistochemical markers are often used to better characterize these lesions. Read More

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Malacoplakia of the Uterine Cervix: A Case Report.

Pathogens 2021 Mar 15;10(3). Epub 2021 Mar 15.

Department of Pathology, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain.

Malacoplakia is an uncommon chronic granulomatous inflammation that rarely affects the female genital tract. A case of a 78-year-old woman with malacoplakia involving the uterine cervix and the vagina is described. The patient complained of vaginal bleeding. Read More

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Mimickers of Urothelial Carcinoma and the Approach to Differential Diagnosis.

Clin Pract 2021 Feb 25;11(1):110-123. Epub 2021 Feb 25.

Department of Pathology, Cruces University Hospital, Biocruces-Bizkaia Health Research Institute, 48903 Barakaldo, Spain.

A broad spectrum of lesions, including hyperplastic, metaplastic, inflammatory, infectious, and reactive, may mimic cancer all along the urinary tract. This narrative collects most of them from a clinical and pathologic perspective, offering urologists and general pathologists their most salient definitory features. Together with classical, well-known, entities such as urothelial papillomas (conventional (UP) and inverted (IUP)), nephrogenic adenoma (NA), polypoid cystitis (PC), fibroepithelial polyp (FP), prostatic-type polyp (PP), verumontanum cyst (VC), xanthogranulomatous inflammation (XI), reactive changes secondary to BCG instillations (BCGitis), schistosomiasis (SC), keratinizing desquamative squamous metaplasia (KSM), post-radiation changes (PRC), vaginal-type metaplasia (VM), endocervicosis (EC)/endometriosis (EM) (müllerianosis), malakoplakia (MK), florid von Brunn nest proliferation (VB), cystitis/ureteritis cystica (CC), and glandularis (CG), among others, still other cellular proliferations with concerning histological features and poorly understood etiopathogenesis like IgG4-related disease (IGG4), PEComa (PEC), and pseudosarcomatous myofibroblastic proliferations (post-operative spindle cell nodule (POS), inflammatory myofibroblastic tumor (IMT)), are reviewed. Read More

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February 2021

An ulcerated violaceous nodule on the thigh.

JAAD Case Rep 2021 Mar 18;9:61-63. Epub 2021 Jan 18.

Department of Dermatology, Stanford University, Redwood City, California.

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Perianal cutaneous malakoplakia in an allogeneic stem cell transplant recipient.

J Cutan Pathol 2021 Jan 20. Epub 2021 Jan 20.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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January 2021

Coexistence of malacoplakia and mullerianosis in the urinary bladder: An uncommon pathology.

Indian J Urol 2020 Oct-Dec;36(4):321-323. Epub 2020 Oct 1.

Department of Urology, Sai Urology Hospital, Aurangabad, Maharashtra, India.

Malacoplakia is an inflammatory lesion which can affect any organ in the body but predominantly affects the genitourinary system and mainly the bladder. Malacoplakia of the bladder has variable presentations and is associated with urinary infection or immunosuppression. Mullerianosis of the bladder is a rare lesion that consists of two out of the three tissues, endometriosis, endocervicosis, or endosalpingiosis. Read More

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October 2020

[Renal granulomatous nephritis: Histopathological point of view].

Ann Pathol 2021 Apr 1;41(2):166-175. Epub 2020 Dec 1.

UMR9020 - UMR-S 1277, Inserm, CNRS, nephrology department, cancer heterogeneity, plasticity and resistance to therapies, Canther, CHU de Lille, université Lille, 59000 Lille, France.

Granulomatous interstitial nephritis (NIG) is a rare form of interstitial nephritis that can be related to acute or chronic clinical presentation. NIG is characterized by granulomas located to the renal interstitium and composed of either epithelioid histiocytes with giant cells and/or of foreign body reaction. The symptoms are unspecific and associate varying degrees of renal failure with abnormal urinanalysis. Read More

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Uterine Malakoplakia Identified by Diagnostic Hysteroscopy.

J Minim Invasive Gynecol 2021 May 22;28(5):924-926. Epub 2020 Nov 22.

Departments of Obstetrics and Gynecology (Drs. Wu, Wang, Weng, and Chao), Chang Gung Memorial Hospital Linkou Medical Center; Gynecologic Cancer Research Center, Chang Gung University College of Medicine (Dr. Chao), Taoyuan, Taiwan. Electronic address:

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Malakoplakia Presenting as a Mass in the Transplanted Kidney: A Malignancy Mimicker on PET/CT.

Clin Nucl Med 2021 Jan;46(1):60-62

From the Department of Nuclear Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Malakoplakia is a rare inflammatory condition that can affect many organ systems, including the genitourinary tract. It is associated with impaired immune function. Isolated renal parenchymal involvement has been reported in very few cases. Read More

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January 2021

Exuberant Malakoplakia of the Prostate Presenting as Prostatic Abscesses in an Immunocompromised Patient.

J Endourol Case Rep 2020 17;6(3):231-234. Epub 2020 Sep 17.

Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.

Malakoplakia is a rare benign lesion, usually associated with deficient intralysosomal degradation of microorganisms, more commonly, . Malakoplakia occurs in various organ systems, the most frequently affected site being the urinary bladder. We report a rare case of isolated extensive malakoplakia involving the prostate, diagnosed on transurethral resection performed for radiologically suspected prostatic abscesses. Read More

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September 2020

A rare renal malakoplakia mimicking renal tumor presenting with deep vein thrombosis and bilateral pulmonary embolism in a 58-year-old woman.

Urol Case Rep 2021 Jan 28;34:101431. Epub 2020 Sep 28.

Urology Department, Nimes University Hospital, France.

Malakoplakia is an uncommon chronic inflammatory disease that appears as soft plaques in various organs and results from defective macrophage function, which tends to affect immunocompromised and debilitated patients. The pseudotumoral form presentation is rare especially with para-neoplastic syndrome. Preoperative diagnosis of renal malakoplakia in appropriate clinical settings can prevent unnecessary surgery. Read More

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January 2021

Colonic malakoplakia in a dual stem cell and cardiac transplant recipient: A case report and literature review.

Transpl Infect Dis 2021 Apr 22;23(2):e13488. Epub 2020 Oct 22.

St. Vincent's Hospital, Sydney, Australia.

We describe the first published case of malakoplakia in a dual stem cell and cardiac transplant recipient. In the 2 months following cardiac transplantation, our patient developed persistent diarrhea and recurrent E coli bacteremia. Biopsies obtained from areas of colonic thickening revealed malakoplakia. Read More

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Malakoplakia, a malignant mimic.

Bladder (San Franc) 2020 2;7(3):e44. Epub 2020 Sep 2.

Department of Urology, Gosford Hospital, Central Coast Local Health District, NSW, Australia.

Malakoplakia is a chronic inflammatory condition that affects multiple systems, most commonly the urogenital tract. Its clinical presentation is often non-specific, but is typically characterized by recurrent urinary tract infections and haematuria. We report a rare case of intravesical malakoplakia mimicking an aggressive transitional cell carcinoma both in its clinical presentation and in its macroscopic appearance on cystoscopy in an 82-year patient, the oldest reported case in the literature. Read More

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September 2020

Malakoplakia of the gastrointestinal tract: clinicopathologic analysis of 23 cases.

Diagn Pathol 2020 Jul 24;15(1):97. Epub 2020 Jul 24.

Department of Pathology and Cell Biology, Columbia University Medical Center, 630 West 168th Street, VC14-240A, New York, NY, 10032, USA.

Background: Malakoplakia is an uncommon, tumor-like inflammatory disease characterized by impaired histiocytes that are unable to completely digest phagocytized bacteria. The genitourinary tract is the most common site of involvement, however, cases have also been described in the gastrointestinal tract, suggesting that it is the second most common site of involvement. This study investigates the clinical and histologic features of malakoplakia in the gastrointestinal tract. Read More

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Pelvic malakoplakia presenting as endometrial cancer: a case report.

Obstet Gynecol Sci 2020 Jul 30;63(4):538-542. Epub 2020 Jun 30.

Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Malakoplakia is a rare granulomatous, inflammatory disease generally manifesting as ulcers of the urogenital tract, especially in the bladder, but it can occur in any part of the body. Because of its varied clinical presentations, malakoplakia is considered for differential diagnosis upon suspicion. The final diagnosis is confirmed by the presence of Michaelis-Gutmann bodies. Read More

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Unexpected endometrial malacoplakia related to abortion and placental rests retention: a case report.

Diagn Pathol 2020 Jul 18;15(1):88. Epub 2020 Jul 18.

Section of Pathology, D.E.T.O. (Department of Emergency and Organ Transplantation), University of Bari, Piazza Giulio Cesare 11, 70124, Bari, BA, Italy.

Background: Malacoplakia is a rare chronic inflammatory disease. The name derives from the Greek "μαλακός" meaning "soft" and "πλάξ" meaning "plaque", describing its usual macroscopic presentation as a friable yellow soft plaque. It was first described by von Hansemann in 1901 and by Michaelis and Gutmann in 1902. Read More

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Rectal malakoplakia.

Proc (Bayl Univ Med Cent) 2020 Jul 18;33(3):389-390. Epub 2020 May 18.

Department of Gastroenterology, State University of New York Upstate Medical UniversitySyracuseNew York.

Malakoplakia is a rare chronic granulomatous disease with potential to affect multiple organs. Gastrointestinal involvement is considered one of the most common locations outside of the urinary tract. Herein, we present the case of a man who presented to our clinic with painless hematochezia. Read More

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Fine-Needle Aspiration of Malakoplakia Presenting as a Peri-rectal Mass after Intestinal Transplant.

J Cytol 2020 Apr-Jun;37(2):110-111. Epub 2020 Apr 2.

Department of Pathology and Laboratory Medicine, Medstar Georgetown University Hospital, Washington DC, USA.

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Poor bladder compliance due to malacoplakia with xanthogranulomatous cystitis: A case report.

Medicine (Baltimore) 2020 Jun;99(26):e20852

Continence Research Clinic, The Central Hosptial of Shaoyang, Shaoyang, China.

Rationale: Either malacoplakia or xanthogranulomatous cystitis (XC) is a rare chronic infection disease of urinary bladder, which often mimics bladder masses undifferentiated from malignance and results in severe lower urinary tract symptoms. The malacoplakia combined with XC is even rarer in the literature.

Patient Concerns: A 64-year-old female, who presented with nocturia, frequency of micturition, severe urgency with occasional urinary incontinence, and recurrent hematuria for >2 years, was diagnosed with azotemia and anemia. Read More

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Appendiceal malakoplakia masquerading as a cecal mass.

J Surg Case Rep 2020 May 1;2020(5):rjaa140. Epub 2020 Jun 1.

Colon and Rectal Surgery, Kelsey-Seybold Clinic, Houston, TX, USA.

Appendiceal malakoplakia masquerading as a cecal mass is uniquely rare. The presence of an infiltrate of granular eosinophilic macrophages containing Michaelis-Gutmann bodies on histopathology is pathognomonic of malakoplakia. Cutaneous, gastrointestinal and most commonly urogenital malakoplakia is reported in association with an immunocompromised state, infectious, inflammatory and neoplastic processes. Read More

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Gallbladder malakoplakia masquerading as malignant primary on 18F-FDG PET/CT.

Eur J Nucl Med Mol Imaging 2021 01 13;48(1):323-324. Epub 2020 May 13.

Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Homi Bhabha National Institute, E. Borges road, Parel, Mumbai, 400012, India.

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January 2021

Mischievous malakoplakia: A potential pitfall of mpMRI of the prostate?

Urol Case Rep 2020 Sep 24;32:101222. Epub 2020 Apr 24.

Section of Urology, Department of Surgery, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, 03756, USA.

Interpretation of multiparametric magnetic resonance imaging (mpMRI) for prostate cancer diagnosis and staging can be challenging and, in some cases, benign prostate disease can mimic locally advanced malignancy. We present the case of a 57 year-old male with biopsy-proven Gleason 3 + 4 prostate cancer and a preoperative mpMRI showing extraprostatic extension who was later found to have infiltrating malakoplakia on final surgical pathology. This case highlights the importance of recognizing that malakoplakia of the prostate can present as a PI-RADS 5 lesion with extracapsular extension on mpMRI. Read More

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September 2020

Renal malakoplakia mimicking a malignancy and diagnosed by fine-needle aspiration: A case report.

Diagn Cytopathol 2020 Nov 2;48(11):1093-1097. Epub 2020 May 2.

Department of Pathology, University of Colorado, Aurora, Colorado.

Malakoplakia is a rare, granulomatous disease that affects a wide variety of organs and can have a clinical and radiographic presentation resembling that of malignancy. The genitourinary tract is the most commonly involved site. There are scant reported cases presenting as a locally advanced renal mass and even rarer, diagnosed by fine-needle aspiration (FNA) cytology. Read More

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November 2020