1,136 results match your criteria Malakoplakia


Colonic Malakoplakia with Retroperitoneal Extension Mimicking Advanced Colon Cancer.

J Gastrointest Surg 2022 Jun 17. Epub 2022 Jun 17.

Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

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Cutaneous malakoplakia with verruciform xanthoma in the same lesion.

Clin Exp Dermatol 2022 Mar 31. Epub 2022 Mar 31.

Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, China.

Cutaneous malakoplakia (CM) is a rare, chronic, granulomatous disease characterized histopathologically by Michaelis-Gutmann bodies (MGB). Verruciform xanthoma (VX) is a rare, benign lesion characterized histopathologically by epithelial papillomatous hyperplasia, local hyperkeratosis with incomplete keratosis, infiltration of foam cells and inflammatory cells in the papillary dermis. We present an elderly Chinese man with CM and coexisting VX with histological confirmation of MGB. Read More

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Clinical Analysis of Renal Failure Caused by Malakoplakia: A Case Report and Literature Review.

Front Med (Lausanne) 2022 3;9:770731. Epub 2022 Mar 3.

Department of Urology Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.

Background: A 52-year-old middle-aged woman developed fatigue, poor appetite and elevated CRE levels 6 months ago without known causes of these symptoms. After repeated anti-infective and renal function improvement treatment, her symptoms did not significantly improve and local progress. Pathological examination confirmed soft spot disease of left kidney and bladder. Read More

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[Cutaneous malakoplakia: A rare pseudo-tumor to know in immunocompromised patients].

Nephrol Ther 2022 Jun 5;18(3):213-215. Epub 2022 Mar 5.

Service de dermatologie, Centre hospitalier universitaire de Martinique, CS 90632, 97261 Fort de France cedex, Martinique.

Cutaneous malakoplakia is a rare pseudo-tumor that occurs in immunocompromised patients. It is a reaction to an infection caused by Gram negative bacteria. The clinical presentation is nonspecific and the diagnosis is histological. Read More

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[A case of tonsil malakoplakia].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Feb;57(2):204-206

Department of Otorhinolaryngology the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China.

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February 2022

Isolated ureteral malakoplakia: A conservative endoscopic approach with a strict follow-up.

Urol Case Rep 2022 Mar 22;41:101986. Epub 2021 Dec 22.

Department of Urology, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.

Ureteral malakoplakia is a rare pathological entity. We report the case of a 54-years-old woman with a single ureteral malakoplakic lesion. Patient presented with history of recurrent urinary tract infections and asymptomatic dilatation of right pelvis. Read More

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Xanthogranulomatous cystitis with malakoplakia leading to recurrent spontaneous bladder perforation in a young girl.

Urol Case Rep 2022 Mar 16;41:101984. Epub 2021 Dec 16.

Department of Urology, King George's Medical University, Chowk, Lucknow, Uttar Pradesh, 226003, India.

Recurrent bladder perforation due to xanthogranulomatous cystitis with malakoplakia is rare entity and can lead to spontaneous bladder perforation. A 15 years girl presented with sudden pain abdomen with reduced urine output. Her exploratory laparotomy revealed, perforation of 2 cm at the dome of bladder with unhealthy margins. Read More

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[An unusual association of malakoplakia and adenocarcinoma of the prostate].

Rev Esp Patol 2022 Jan-Mar;55(1):46-51. Epub 2019 Aug 22.

Departamento de Anatomía Patológica, Hospital y Fundación Clínica Médica Sur, Ciudad de México, México. Electronic address:

Malakoplakia is a chronic inflammatory process caused by a lysosomal defect in bacterial digestion. Although rare, it occurs more frequently in the genitourinary tract and in patients with immune dysfunction. The bladder is the most commonly affected site, although cases have been reported in other organs, including the prostate gland. Read More

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Malakoplakia Presenting as a Lung Mass in a Lung Transplant Recipient: Case Report.

Transplant Proc 2022 Jan-Feb;54(1):173-175. Epub 2021 Dec 29.

Columbia University Lung Transplant Program, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, New York, NY.

Lung nodules or masses due to a variety of malignant or benign conditions such as opportunistic infections are observed after lung transplant. Malakoplakia is a rare complication in immunocompromised patients. Here we describe the clinical course and management of a lung transplant recipient with pulmonary malakoplakia and provide a review of the literature. Read More

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February 2022

Malakoplakia of the urinary bladder in a young French Bulldog.

J Am Vet Med Assoc 2021 12 27;260(5):543-548. Epub 2021 Dec 27.

Case Description: A 4-month-old 5.9-kg sexually intact female French Bulldog was presented because of recurrent urinary tract infections in combination with pollakiuria, hematuria, and urinary incontinence.

Clinical Findings: A diagnosis of malakoplakia was made on the basis of results of hematologic and serum biochemical testing, abdominal ultrasonography, bacterial culture, and cystoscopic biopsies of the urinary bladder wall. Read More

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December 2021

The necessity of transperineal ultrasound view in urethra malacoplakia.

J Clin Ultrasound 2022 Feb 10;50(2):224-226. Epub 2021 Dec 10.

Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

This case illustrates the untypical presentation of primary bladder malacoplakia. The patient was in her mid-50s have impaired immunity by the long-term hyperglycemic condition. She presented with symptoms of urinary tract infection and dysuria, and had multiple nodulars in bladder and significantly mass in urethra. Read More

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February 2022

Xanthogranulomatous Pyelonephritis and Its Differential Diagnoses: An In-Depth Case Review.

Cureus 2021 Oct 29;13(10):e19133. Epub 2021 Oct 29.

Epidemiology and Public Health, Ciencias de la Salud, Fundación Universidad del Norte, Barranquilla, COL.

Xanthogranulomatous pyelonephritis is a rare chronic infectious process of the kidney, which has been described in three different forms: diffuse, segmental, and focal. It is also known as the great simulator since its clinical, radiological, and histopathological manifestations tend to be confused with other entities. We describe a case of a 55-year-old male patient with two months of clinical manifestations characterized by a 7x7-cm palpable mass in his right lumbar region, which was hot and painful upon touch and increasing in size. Read More

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October 2021

Malakoplakia of Endometrium with Osseous Metaplasia on Evaluation of Postmenopausal Leukorrhea: A Rare Case Report.

J Midlife Health 2021 Jul-Sep;12(3):237-240. Epub 2021 Oct 16.

Department of Obstetrics and Gynaecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Malakoplakia is a chronic xanthogranulomatous condition that affects the genitourinary tract reported earlier as urinary granulomas and pelvic masses. We report a different clinical manifestation of malakoplakia presenting as postmenopausal pyometra. A 64-year-old postmenopausal female presented with foul-smelling vaginal discharge with a past history of induced abortion, followed by dilatation and evacuation. Read More

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October 2021

Granulomatous and xanthogranulomatous prostatitis: A case report.

Urol Case Rep 2022 Jan 12;40:101887. Epub 2021 Oct 12.

Department of Surgery, Urology Section, Hamad Medical Corporation, Doha, Qatar.

Granulomatous prostatitis is a rare condition that is diagnosed only by histopathological examination. Though rare, the condition was reported to have different presentations (mimicking prostate cancer or prostatitis and prostatic abscess) and to have different etiologies which classified it into three main entities; nonspecific (idiopathic), post-surgery, and specific. Specific granulomatous prostatitis is further sub-classified to infective, xanthogranulomatous, Malacoplakia and associated with systemic granulomatous disease and allergy. Read More

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January 2022

Malakoplakia as a Rare Cause of Diarrhea: Case Presentation and Review of Literature.

Middle East J Dig Dis 2021 Jan 2;13(1):71-74. Epub 2021 Mar 2.

Professor of Gastroenterology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Colonic malakoplakia is a rare chronic granulomatous disease that can involve many organs such as the lung, brain, pancreas, bone, adrenal glands, and genitourinary tract. The most common site of involvement outside the genitourinary tract is the gastrointestinal tract. We report a case of colonic malakoplakia who presented with unintentional weight loss, abdominal pain, and chronic diarrhea. Read More

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January 2021

Malakoplakia presenting as Pleuropulmonary masses: A rare clinical, radiological and histopathological diagnosis.

Radiol Case Rep 2021 Dec 8;16(12):3859-3863. Epub 2021 Sep 8.

Department of Radiology, Royal Oldham Hospital, Pennine Acute hospitals NHS Trust, United Kingdom.

Pleuropulmonary malakoplakia is a rare granulomatous inflammatory condition characterized by the accumulation of histiocytes that contain basophilic inclusions called Michaelis-Gutmann bodies . It is usually reported in patients with acquired immunodeficiency syndrome. We present clinical, radiological, pathological features and management of a rare case of pulmonary malakoplakia in an immunocompetent male patient with a past history of empyema treated with surgical decortication. Read More

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December 2021

Malakoplakia of the bladder near the ureteral orifice: a case report.

J Int Med Res 2021 Oct;49(10):3000605211050799

Department of Urology, Second People's Hospital of Yichang, Second People's Hospital of China Three Gorges University, Yichang, Hubei, China.

Malakoplakia, a rare acquired granulomatous disease, affects many systems, including the urogenital tract. The literature describes malakoplakia of different viscera, and satisfactory results have been obtained after treatment. We reported a 48-year-old patient with diabetes who received multiple treatments in our hospital for bladder malakoplakia near the ureteral orifice. Read More

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October 2021

Case Report: Malacoplakia Due to With Infection of a Transplanted Kidney in a Patient With Recurrent Urinary Tract Infection.

Front Med (Lausanne) 2021 14;8:721145. Epub 2021 Sep 14.

Department of Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Colonization of rarely occurs in a graft. This study reports a case of malacoplakia and cryptococcoma caused by and in a transplanted kidney, with detailed pathology and metagenome sequencing analysis. We presented a case of cryptococcoma and malacoplakia in the genitourinary system including the transplant kidney, bladder, prostate, and seminal vesicles caused by and in a renal-transplant recipient. Read More

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September 2021

Xanthogranulomatous Pyelonephritis: A Narrative Review with Current Perspectives on Diagnostic Imaging and Management, Including Interventional Radiology Techniques.

Int J Nephrol Renovasc Dis 2021 7;14:359-369. Epub 2021 Sep 7.

Division of Interventional Radiology, Department of Radiology, University Hospital Waterford, Waterford City, X91 DWX0, Ireland.

Xanthogranulomatous Pyelonephritis (XGP) is a rare, chronic granulomatous inflammatory condition thought to arise secondary to a combination of obstruction, recurrent bacterial infection and an incomplete immune response resulting in focal or diffuse renal destruction. This destruction may be profound with the potential to infiltrate surrounding tissues and viscera. The imaging features of XGP can be ambiguous, mimicking malignancy, tuberculosis (TB) and malakoplakia earning the title of "the great imitator". Read More

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September 2021

Malakoplakia and xanthogranulomatous pyelonephritis treated with nephrectomy: A case report.

Medicine (Baltimore) 2021 Sep;100(36):e27137

Department of Urology, Taipei Municipal Wanfang Hospital, Taipei, Taiwan.

Rationale: Malakoplakia and xanthogranulomatous pyelonephritis are chronic inflammatory conditions of the kidney characterized by the infiltration of inflammatory cells.

Patient Concerns: An 82-year-old female patient had a history of hypertension, type 2 diabetes mellitus, dyslipidemia, and end-stage renal disease under hemodialysis. She was admitted repeatedly 4 times within 4 months due to urosepsis. Read More

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September 2021

Surgically Managed Malakoplakia of the Spine: A Case Report.

JBJS Case Connect 2021 09 2;11(3). Epub 2021 Sep 2.

From the Department of Orthopaedics, The Johns Hopkins Hospital, Baltimore, Maryland.

Case: A 66-year-old woman with polymyositis and recurrent urinary tract infections presented with lumbar pain and progressive lower extremity neuropathy. Imaging showed lytic destruction of the vertebral bone from L2 to L4 with extension into adjacent musculature. Histological examination demonstrated Michaelis-Gutmann bodies consistent with malakoplakia. Read More

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September 2021

Renal graft malakoplakia masquerading post-transplant lymphoproliferative disorder.

BMJ Case Rep 2021 Aug 16;14(8). Epub 2021 Aug 16.

Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India

A 45-year-old woman presented to us in March 2019 with complaints of fever and right lower quadrant abdominal pain for 1 month. She had undergone renal transplantation in 2017 for end-stage renal disease and developed four episodes of urinary tract infection in the next 16 months post transplantation, which were treated based on culture reports. She was subsequently kept on long-term prophylaxis with trimethoprim and sulfamethoxazole. Read More

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Malakoplakia prostate presenting as urinary retention: a report of two cases and review of the literature.

BMJ Case Rep 2021 Jul 28;14(7). Epub 2021 Jul 28.

Department of Urology, LTMMC & GH, Mumbai, Maharashtra, India.

Malakoplakia is a rare chronic inflammatory condition, which primarily occurs in genitourinary tract, with prostatic malakoplakia being extremely rare. We present two cases of acute urinary retention, with clinically firm nodular prostate and a raised serum prostate-specific antigen. Transrectal ultrasound-guided prostatic biopsy showed features of malakoplakia. Read More

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Multivisceral Resection for Colonic Splenic Flexure Malakoplakia: A Minimally Invasive Approach.

Ann Coloproctol 2021 Jul 21. Epub 2021 Jul 21.

Division of Colorectal Surgery, Surgery Department, Hospital Central Militar, Secretaría de la Defensa Nacional, Mexico City, Mexico.

Malakoplakia is a rare granulomatous inflammatory disorder. Its diagnosis depends on histopathological findings; however, high-quality literature regarding proper medical/surgical treatment is lacking. A 38-year-old diabetic female patient was admitted to the emergency room with a history of lower gastrointestinal hemorrhage. Read More

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Malakoplakia mimicking a locally advanced colorectal neoplasm.

J Surg Case Rep 2021 Jun 4;2021(6):rjab225. Epub 2021 Jun 4.

Colorectal Surgery Unit, Surgery Service, Complejo Asistencial Doctor Sótero Del Río, Santiago 8207257, Chile.

Malakoplakia is a rare disease. Clinical presentation is non-specific, making its diagnosis an incidental finding on histopathological analysis. The aim of this case report is to describe a patient diagnosed with colon, renal and soft tissue malacoplakia mimicking a locally advanced colorectal cancer. Read More

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Mimicker of malignancy, malakoplakia presenting as PI-RADS 5 lesion in mp-MRI-A case report.

Indian J Cancer 2021 Apr-Jun;58(2):307-309

Department of Urology, Amrita Institute of Medical Sciences and Research Center, Kochi, Kerala, India.

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December 2021

CT and pathological features in renal parenchymal malakoplakia: a case report and review of the literature.

Authors:
Yuanfen Yang

Aktuelle Urol 2021 May 18. Epub 2021 May 18.

Departments of Radiology, Xintai people's Hospital, Xintai, China.

Renal malakoplakia is a rare form of chronic inflammatory granulomatous disease in the kidney. It occurs in adult patients with immunocompromised status or debilitating disease. In the present study, we reported a case of a 50-year-old woman with no underlying disease. Read More

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Necrotizing skin and soft tissue infection with malakoplakia-like features mimicking pyoderma gangrenosum.

JAAD Case Rep 2021 Jun 8;12:1-4. Epub 2021 Apr 8.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

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Successful use of azithromycin for Escherichia coli-associated renal allograft malakoplakia: a report of two cases.

Eur J Clin Microbiol Infect Dis 2021 Dec 14;40(12):2627-2631. Epub 2021 May 14.

Department of Infectious Diseases, Austin Health, 145 Studley Road, Heidelberg, Victoria, 3084, Australia.

Malakoplakia is a chronic granulomatous disease associated with incomplete clearance of bacterial pathogens. A multimodal approach to therapy includes antimicrobials with intracellular activity, reduction in immunosuppression, and debulking of lesions. Azithromycin has an intracellular mechanism of action and enhanced Gram-negative activity compared to other macrolides. Read More

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December 2021

Malakoplakia in the Urinary Bladder of 4 Puppies.

Vet Pathol 2021 07 23;58(4):699-704. Epub 2021 Apr 23.

311308Purdue University, West Lafayette, IN, USA.

Malakoplakia in humans most often affects the urinary bladder and is characterized by inflammation with von Hansemann-type macrophages, with or without Michaelis-Gutmann bodies, and is frequently associated with infection. We describe the microscopic features of malakoplakia in the urinary bladder of 4 puppies. In all cases, the lamina propria of the urinary bladder was markedly expanded by sheets of large, round to polygonal macrophages with intracytoplasmic, periodic acid-Schiff-positive granules and granular inclusions, and rare Prussian blue-positive inclusions. Read More

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