45,657 results match your criteria Malabsorption


Potential contribution of the gut microbiota to hypoglycemia after gastric bypass surgery.

Chin Med J (Engl) 2020 Jul 7. Epub 2020 Jul 7.

Key Laboratory of Endocrinology, Translational Medicine Center, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

Obesity has become a global health problem. Lifestyle modification and medical treatment only appear to yield short-term weight loss. Roux-en-Y gastric bypass (RYGB) is the most popular bariatric procedure, and it sustains weight reduction and results in the remission of obesity-associated comorbidities for obese individuals. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000932DOI Listing

Oral Alanyl-Glutamine for Inflammation, Nutrition, & Enteropathy: A Randomized Dose-Response Controlled Trial in Children.

J Pediatr Gastroenterol Nutr 2020 Jul 8. Epub 2020 Jul 8.

Department of Physiology and Pharmacology, Clinical Research Unit & Institute of Biomedicine/Center for Global Health, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Objective: Determine the minimum dosage of alanyl-glutamine (Ala-Gln) required to improve gut integrity and growth in children at risk of environmental enteropathy (EE).

Methods: This was a double-blinded randomized placebo-controlled dose-response trial. We enrolled 140 children residing in a low-income community in Fortaleza, Brazil. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002834DOI Listing

The effect of 8 plant extracts and combinations on post-prandial blood glucose and insulin responses in healthy adults: a randomized controlled trial.

Nutr Metab (Lond) 2020 6;17:51. Epub 2020 Jul 6.

Unilever R&D Shanghai, Shanghai, China.

Background: Lower post-prandial glucose (PPG) and insulin (PPI) responses to foods are associated with reduced diabetes risk and progression. Several plant extracts have been proposed to reduce PPG or PPI by inhibiting enzymes or transporters involved in carbohydrate digestion and uptake. This study evaluates a range of such extracts, consumed with a carbohydrate load, for their effects on PPG, PPI and indicators of (gastrointestinal) tolerance. Read More

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http://dx.doi.org/10.1186/s12986-020-00471-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336677PMC

Autoimmune gastritis.

Nat Rev Dis Primers 2020 Jul 9;6(1):56. Epub 2020 Jul 9.

Department of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy.

Autoimmune gastritis (AIG) is an increasingly prevalent, organ-specific, immune-mediated disorder characterized by the destruction of gastric parietal cells, leading to the loss of intrinsic factor and reduced acid output. These alterations result in malabsorption of iron, vitamin B (pernicious anaemia) and potentially other micronutrients. For several years, most studies have focused on pernicious anaemia only, generating confusion between the two entities. Read More

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http://dx.doi.org/10.1038/s41572-020-0187-8DOI Listing

Considering histamine in functional gastrointestinal disorders.

Crit Rev Food Sci Nutr 2020 Jul 9:1-8. Epub 2020 Jul 9.

Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria.

In westernized countries, adverse reactions to ingested foods are reported to affect up to 20% of the population. Functional, nonspecific, non-allergic gastrointestinal complaints are mainly due to the intolerance/malabsorption of carbohydrates (lactose and fructose), proteins (gluten), and biogenic amines (histamine). Food intolerance/malabsorption is defined by one or several of the above mentioned food components not being degraded and/or absorbed properly within the gastrointestinal tract. Read More

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http://dx.doi.org/10.1080/10408398.2020.1791049DOI Listing

Omeprazole-induced hypomagnesaemia, causing renal tubular acidosis with hypokalaemia, hypocalcaemia, hyperlactacidaemia and hyperammonaemia.

BMJ Case Rep 2020 Jul 8;13(7). Epub 2020 Jul 8.

Department of Internal Medicine, Ako City Hospital, Ako, Hyogo, Japan.

A 72-year-old Japanese man treated with omeprazole for 11 years was admitted due to loss of consciousness and muscle weakness. Wolff-Parkinson-White syndrome-induced tachycardia was considered as the cause of syncope. His blood examination revealed rhabdomyolysis, hypokalaemia, hypomagnesaemia, hypocalcaemia, hyperlactacidaemia, hyperammonaemia and high-anion-gap metabolic acidosis. Read More

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http://dx.doi.org/10.1136/bcr-2020-235385DOI Listing

Epithelial vectorial ion transport in cystic fibrosis: Dysfunction, measurement, and pharmacotherapy to target the primary deficit.

SAGE Open Med 2020 25;8:2050312120933807. Epub 2020 Jun 25.

Department of Physiology, Neuroscience and Behavioral Sciences, St. George's University, Grenada, West Indies.

Cystic fibrosis patients display multi-organ system dysfunction (e.g. pancreas, gastrointestinal tract, and lung) with pathogenesis linked to a failure of Cl secretion from the epithelial surfaces of these organs. Read More

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http://dx.doi.org/10.1177/2050312120933807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323271PMC

A not so common cause of iron deficiency in inflammatory bowel disease.

Am J Med 2020 Jul 3. Epub 2020 Jul 3.

Insitute of Pathology Saarbrücken-Rastpfuhl, Saarbrücken, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.05.037DOI Listing

Longitudinal gut microbiome changes in alcohol use disorder are influenced by abstinence and drinking quantity.

Gut Microbes 2020 Nov;11(6):1608-1631

Office of the Clinical Director, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism , Bethesda, MD, USA.

Many patients with alcohol use disorder (AUD) consume alcohol chronically and in large amounts that alter intestinal microbiota, damage the gastrointestinal tract, and thereby injure other organs via malabsorption and intestinal inflammation. We hypothesized that alcohol consumption and subsequent abstinence would change the gut microbiome in adults admitted to a treatment program. Stool and oral specimens, diet data, gastrointestinal assessment scores, anxiety, depression measures and drinking amounts were collected longitudinally for up to 4 weeks in 22 newly abstinent inpatients with AUD who were dichotomized as less heavy drinkers (LHD, <10 drinks/d) and very heavy drinkers (VHD, 10 or more drinks/d). Read More

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http://dx.doi.org/10.1080/19490976.2020.1758010DOI Listing
November 2020

Efficacy and safety of parenteral vitamin D therapy in infants and children with vitamin D deficiency caused by intestinal malabsorption.

Ann Pediatr Endocrinol Metab 2020 Jun 30;25(2):112-117. Epub 2020 Jun 30.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Oral supplementation of vitamin D can be inefficient in patients with vitamin D deficiency caused by intestinal malabsorption. This study investigated the efficacy and safety of parenteral vitamin D supplementation in infants and children with vitamin D deficiency caused by intestinal malabsorption.

Methods: This study included 11 patients with vitamin D deficiency who were unresponsive to oral vitamin D or were unable to try oral vitamin D therapy due to underlying conditions. Read More

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http://dx.doi.org/10.6065/apem.1938142.071DOI Listing

[Analysis of the leading pathogenetic factors of dental caries in children with celiac disease].

Stomatologiia (Mosk) 2020 ;99(3):71-73

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

The Aim: To identify the leading pathogenetic factors of dental caries in children with celiac disease.

Material And Methods: The study included 48 children with a confirmed diagnosis of celiac disease at the age of 8-16 years. All the children were examined by a dentist, the oral cavity was sanitized, recommendations for oral care were given. Read More

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http://dx.doi.org/10.17116/stomat20209903171DOI Listing

Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures.

Open Access Rheumatol 2020 11;12:105-115. Epub 2020 Jun 11.

Rheumatology Department, Espíritu Santo University, Guayaquil, Ecuador.

Introduction: Currently, approximately more than one billion people around the world are considered to have deficient levels of vitamin D. International consensus recommends vitamin D supplementation to high-risk patients (advanced age, osteoporosis, liver failure, malabsorption syndromes, etc.) and those with levels below 30 ng/mL. Read More

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http://dx.doi.org/10.2147/OARRR.S252245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295536PMC

Evaluation of breath, plasma, and urinary markers of lactose malabsorption to diagnose lactase non-persistence following lactose or milk ingestion.

BMC Gastroenterol 2020 Jun 29;20(1):204. Epub 2020 Jun 29.

The Liggins Institute, The University of Auckland, Auckland, New Zealand.

Background: Adult lactase non-persistence (LNP) is due to low lactase expression, resulting in lactose malabsorption (LM). LNP is a genetic trait, but is typically determined by LM markers including breath H, blood glucose, and urinary galactose after a lactose tolerance test. Known validity of these markers using milk is limited, despite being common practice. Read More

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http://dx.doi.org/10.1186/s12876-020-01352-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325051PMC

Nutritional management of celiac crisis in an elderly adult: A case report of the rare presentation of celiac disease in a 75-y-old woman.

Nutrition 2020 May 19;79-80:110858. Epub 2020 May 19.

Unit of Dietetic and Clinical Nutrition, University Hospital Maggiore della Carità, Novara, Italy.

In adults, a very uncommon presentation of celiac disease (CD) is a celiac crisis, a life-threatening and severe form of the disease having a dramatic onset with diarrhea and metabolic acidosis with electrolyte and fluid imbalance. Treatment of celiac crisis requires a gluten-free diet; however, the risk for refeeding syndrome (RFS) should be considered in patients showing marked malabsorption symptoms and important unintentional weight loss. Therefore, to avoid metabolic and potentially fatal complications of re-nutrition, nutritional management is crucial for a safe recovery after a celiac crisis. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110858DOI Listing

Clinical Management of Infectious Diarrhea.

Rev Recent Clin Trials 2020 Jun 28. Epub 2020 Jun 28.

Fondazione Policlinico Universitario A. Gemelli IRCCS - Rome. Italy.

Background: Infectious diarrhea is the most common cause of diarrhea worldwide and is responsible for more deaths than other gastrointestinal tract diseases such as gastrointestinal cancers, peptic ulcer disease or inflammatory bowel disease. Diarrheal disease still represents the 8th leading cause of death worldwide, with more than 1,6 million attributed fatalities in 2016 alone. The majority of cases can be divided into three principal clinical presentations: acute watery diarrhea lasting 5-10 days and normally self-limiting, bloody diarrhea (dysentery), and persistent diarrhea with or without intestinal malabsorption. Read More

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http://dx.doi.org/10.2174/1574887115666200628144128DOI Listing

IBD and Bile Acid Absorption: Focus on Pre-clinical and Clinical Observations.

Front Physiol 2020 12;11:564. Epub 2020 Jun 12.

Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, California Northstate University, Elk Grove, CA, United States.

Inflammatory bowel disease (IBD) causes chronic inflammation affecting the GI tract. It is classified as consisting of Crohn's Disease (CD) and Ulcerative Colitis (UC). Bile Acid absorption is altered in both pre-clinical models of Inflammatory Bowel Disease (IB) and in human IBD. Read More

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http://dx.doi.org/10.3389/fphys.2020.00564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303840PMC

Nutritional management of lactose intolerance: the importance of diet and food labelling.

J Transl Med 2020 Jun 26;18(1):260. Epub 2020 Jun 26.

Dietetics and Clinical Nutrition Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.

Worldwide, 70% of the adult population has limited expression of lactase enzyme with a wide variation among different regions and countries. Lactase deficiency may lead to lactose intolerance (LI). Depending both on the amount of lactose ingested and on the lactase activity, people who suffer from lactose malabsorption might experience numerous gastrointestinal and extra-intestinal symptoms and manifestations. Read More

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http://dx.doi.org/10.1186/s12967-020-02429-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318541PMC

Measures of Dietary Fat and Energy Absorption in Healthy Adults.

Pancreas 2020 Jul;49(6):845-854

Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia.

Objectives: Existing reference ranges for stool fat and energy absorption were developed using subjects in controlled environments on precise diets. This study measured energy and fat absorption in healthy, community-dwelling adults eating a moderate-to-high fat American diet via stool- and serum-based methods.

Methods: This was a secondary analysis of healthy subjects recruited as the comparison group in a chronic pancreatitis study. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001587DOI Listing

Clinical Impact of Antecedent Bariatric Surgery on Liver Transplant Outcomes: A Retrospective Matched Case-control Study.

Transplantation 2020 Jun 23. Epub 2020 Jun 23.

Division of Transplantation, Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota, U.S.A.

Background: Bariatric surgery (BS) may be associated with significant malabsorption and nutritional deficiencies.

Methods: Between March 1987 and January 2017, we performed 922 liver transplants (LT) at our institution; 33 had antecedent BS. We matched the BS cohort to LT recipients without BS (1:3 matching) based on exact matching for gender and cancer and inverse variance matching for age, LT BMI, MELD score, and transplant date. Read More

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http://dx.doi.org/10.1097/TP.0000000000003378DOI Listing

Unequal effects of MYO5B mutations in liver and intestine determine the clinical presentation of low-GGT cholestasis.

Hepatology 2020 Jun 24. Epub 2020 Jun 24.

Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Mutations in the MYO5B gene cause in some patients low gamma-glutamyltransferase (low-GGT) cholestatic liver disease (CLD) and in other patients microvillus inclusion disease (MVID, a congenital diarrheal and malabsorption disorder). Overlap of symptoms occurs but more MVID patients present cholestasis than CLD patients present diarrhea. Clinical observations indicate that MYO5B mutations can cause but also protect against CLD. Read More

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http://dx.doi.org/10.1002/hep.31430DOI Listing

Excess free fructose, apple juice, high fructose corn syrup and childhood asthma risk - the National Children's Study.

Nutr J 2020 Jun 23;19(1):60. Epub 2020 Jun 23.

Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA.

Background: Recent research provides consistent evidence that the unexplained doubling of childhood asthma prevalence (1980-1995), its continued climb and 2013 plateau, may be associated with the proliferation of high-fructose-corn-syrup (HFCS) in the US food supply. The HFCS used in soft drinks has been shown to contain a higher fructose-to-glucose ratio than previously thought. This coincides with a preference shift from orange to apple juice among young children. Read More

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http://dx.doi.org/10.1186/s12937-020-00578-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313206PMC

A novel surgical technique focused on the study of the ileum: The preduodenal ileal transposition.

Cir Cir 2020 ;88(4):402-409

Surgery Unit, Puerto Real University Hospital, Universidad de Cádiz. Cadiz, Spain.

Aims: Our main goal is to study the effects on the carbohydrate metabolism. Thus, we designed various experimental surgical models on healthy non-obese Wistar rats to reproduce several conditions. In this sense, we report a new experimental model. Read More

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http://dx.doi.org/10.24875/CIRU.20001272DOI Listing
January 2020

Lactose Intolerance: What Your Breath Can Tell You.

Diagnostics (Basel) 2020 Jun 17;10(6). Epub 2020 Jun 17.

Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences University, Boston, MA 02115, USA.

Lactose intolerance has seen recognized as a clinical syndrome characterized by pain, abdominal distention, flatulence, and diarrhea after the consumption of lactose. Lactose is a common disaccharide found in dairy that requires lactase-phlorizin hydrolase (LPH) to break down into glucose and galactose. A deficiency in this enzyme results in flora bacteria further along in the gastrointestinal tract (GI) tract to metabolize the excess lactose to numerous gases, including H. Read More

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http://dx.doi.org/10.3390/diagnostics10060412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344825PMC

The Role of Bile Acids in Chronic Diarrhea.

Am J Gastroenterol 2020 Jun 11. Epub 2020 Jun 11.

Division of Gastroenterology and Hepatology, Department of Medicine, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, Rochester, Minnesota, USA.

Bile acids (BAs) are the central signals in enterohepatic communication, and they also integrate microbiota-derived signals into enterohepatic signaling. The tissue distribution and signaling pathways activated by BAs through natural receptors, farsenoid X receptor and G protein-coupled BA receptor 1 (GPBAR1, also known as Takeda G-coupled receptor 5), have led to a greater understanding of the mechanisms and potential therapeutic agents. BA diarrhea is most commonly encountered in ileal resection or disease, in idiopathic disorders (with presentation similar to functional diarrhea or irritable bowel syndrome with diarrhea), and in association with malabsorption such as chronic pancreatitis or celiac disease. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000696DOI Listing

Investigating coeliac disease in adults.

BMJ 2020 06 17;369:m2176. Epub 2020 Jun 17.

Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton SO16 6YD, UK

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http://dx.doi.org/10.1136/bmj.m2176DOI Listing

Meal-Time Supplementation with Betaine HCl for Functional Hypochlorhydria: What is the Evidence?

Integr Med (Encinitas) 2020 Feb;19(1):32-36

Research Associate at the Point Institute.

It is well established that the inadequate of key nutrients can lead to nutrient deficiency-related phenomena. However, even when the intake of nutrients is sufficient, the inadequate digestion and/or absorption of macronutrients, micronutrients or other therapeutic compounds from the diet (i.e. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238915PMC
February 2020

Follow-up after bariatric surgery: A review.

Nutrition 2020 Apr 21;78:110831. Epub 2020 Apr 21.

Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania; 1st Surgery Department, Constanta County Emergency Hospital, Constanta, Romania.

Bariatric surgery is becoming increasingly popular in the treatment of severely obese patients who failed to lose weight with the help of non-surgical interventions. Such patients are at increased risk for premature death, type 2 diabetes, high blood pressure, gallstones, coronary heart disease, dyslipidemia, some cancers, anxiety, depression, and degenerative joint disorders. Although bariatric surgery appears to be the most effective and durable treatment option for obesity, it is associated with a number of surgical and medical complications. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110831DOI Listing
April 2020
2.926 Impact Factor

Case Report: Acute kidney failure leading to permanent haemodialysis due to hyperoxaluria following one-anastomosis gastric bypass-related rapid weight loss.

F1000Res 2020 26;9:155. Epub 2020 Feb 26.

General Surgery Departement, Desio Hospital, Desio, Italy, 20843, Italy.

The one-anastomosis gastric bypass (OAGB) has been proven to provide good weight loss, comorbidity improvement, and quality of life with follow-up longer than five years. Although capable of improving many obesity-related diseases, OAGB is associated with post-operative medical complications mainly related to the induced malabsorption. A 52-year-old man affected by nephrotic syndrome due to a focal segmental glomerulosclerosis underwent OAGB uneventfully. Read More

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http://dx.doi.org/10.12688/f1000research.22109.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265574.2PMC
February 2020

Lysophosphatidic Acid Increases Maturation of Brush Borders and SGLT1 activity in MYO5B-deficient Mice, a Model of Microvillus Inclusion Disease.

Gastroenterology 2020 Jun 11. Epub 2020 Jun 11.

Section of Surgical Sciences, Vanderbilt University Medical Center; Epithelial Biology Center, Vanderbilt University School of Medicine; Cell and Developmental Biology, Vanderbilt University School of Medicine; Nashville Veterans Affairs Medical Center, Nashville TN.

Background & Aim: Myosin VB (MYO5B) is an essential trafficking protein for membrane recycling in gastrointestinal epithelial cells. The inactivating mutations of MYO5B cause the congenital diarrheal disease, microvillus inclusion disease (MVID). MYO5B deficiency in mice causes mislocalization of SGLT1 and NHE3, but retained apical function of CFTR, resulting in malabsorption and secretory diarrhea. Read More

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http://dx.doi.org/10.1053/j.gastro.2020.06.008DOI Listing

Dietary Macronutrient Distribution and Nutrition Outcomes in Persons with Cystic Fibrosis: An Evidence Analysis Center Systematic Review.

J Acad Nutr Diet 2020 Jun 9. Epub 2020 Jun 9.

Cystic fibrosis (CF) increases risk for undernutrition and malabsorption. Individuals with CF traditionally have been counseled to consume a high-fat diet. However, a new era of CF care has increased lifespan and decreased symptoms in many individuals with CF, necessitating a re-examination of the high-fat CF legacy diet. Read More

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http://dx.doi.org/10.1016/j.jand.2020.03.016DOI Listing

Gluten hydrolyzing activity of Bacillus spp isolated from sourdough.

Microb Cell Fact 2020 Jun 12;19(1):130. Epub 2020 Jun 12.

SDM Research Institute for Biomedical Sciences (SDMRIBS), Shri Dharmasthala Manjunatheshwara University, Manjushree Nagar, Dharwad, Karnataka, 580 009, India.

Background: Celiac disease is an intestinal chronic disorder with multifactorial etiology resulting in small intestinal mucosal injuries and malabsorption. In genetically predisposed individuals with HLA DQ2/DQ8 molecules, the gluten domains rich in glutamine and proline present gluten domains to gluten reactive CD4 T cells causing injury to the intestine. In the present experimental design, the indigenous bacteria from wheat samples were studied for their gluten hydrolyzing functionality. Read More

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http://dx.doi.org/10.1186/s12934-020-01388-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291523PMC
June 2020
4.221 Impact Factor

Pancreatic Insufficiency in Patients Under Sorafenib Treatment for Hepatocellular Carcinoma.

J Clin Gastroenterol 2020 Jun 19. Epub 2020 Jun 19.

Barcelona Clinic Liver Cancer (BCLC) Group, Liver Unit.

Goals: To describe the occurrence of malabsorption (MA) in hepatocellular carcinoma (HCC) patients under sorafenib, the potential relationship with pancreatic insufficiency (PI), and the role of pancreatic enzymes supplementation.

Background: With the increasing options of second-line systemic therapies for HCC, the recognition of drug intolerance using practical tools is crucial. It has been proposed that a MA syndrome could be due to sorafenib-induced pancreatic dysfunction. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001366DOI Listing

A Rare Cause of Bilateral Corneal Ulcers: Vitamin A Deficiency in the Setting of Chronic Alcoholism.

Cureus 2020 May 6;12(5):e7991. Epub 2020 May 6.

Internal Medicine, State University of New York (SUNY) Upstate Medical University, Syracuse, USA.

Vitamin A deficiency is rarely encountered in the western world. When encountered, vitamin A deficiency is seen as a component of the malabsorption spectrum of disease. Given the infrequency of nutritional deficits in the developed world, vitamin A-associated ophthalmologic disease is rarely encountered. Read More

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http://dx.doi.org/10.7759/cureus.7991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274257PMC

Pathogenesis and Clinical Management of Mesenteric Fibrosis in Small Intestinal Neuroendocine Neoplasms: A Systematic Review.

J Clin Med 2020 Jun 8;9(6). Epub 2020 Jun 8.

1st Department of Propaedeutic Internal Medicine, Endocrine Unit, National and Kapodistrian, University of Athens, 11527 Athens, Greece.

Mesenteric fibrosis (MF) constitutes an underrecognized sequela in patients with small intestinal neuroendocrine neoplasms (SI-NENs), often complicating the disease clinical course. The aim of the present systematic review, carried out by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, is to provide an update in evolving aspects of MF pathogenesis and its clinical management in SI-NENs. Complex and dynamic interactions are present in the microenvironment of tumor deposits in the mesentery. Read More

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http://dx.doi.org/10.3390/jcm9061777DOI Listing

Early-onset refractory diarrhea due to immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome associated with a novel mutation in the gene: A case report.

World J Clin Cases 2020 May;8(10):1988-1994

Department of Pediatric Hematology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China.

Background: Immune dysregulation, polyendocrinopthy, enteropathy, X-linked (IPEX) syndrome is a rare X-linked recessive disease caused by mutations in the forkhead box protein 3 () gene, which is a master transcriptional regulator for the development and function of CD4CD25 regulatory T (Treg) cells. The dysfunction of these cells leads to multiple system autoimmune diseases. We present a case of IPEX due to a mutation not reported in the literature before. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i10.1988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262694PMC

Outer retina changes on optical coherence tomography in vitamin A deficiency.

Int J Retina Vitreous 2020 5;6:23. Epub 2020 Jun 5.

Johns Hopkins School of Medicine, Wilmer Eye Institute, 600 N. Wolfe Street, Woods 459A, Baltimore, MD 21287 USA.

Background: Vitamin A deficiency is rare in the United States and can be missed in patients with malabsorption syndromes without a high dose of suspicion. Ocular complications of hypovitaminosis A include xerosis and nyctalopia, and to a lesser extent reduction in visual acuity and color vision. Outer retinal changes, as seen on spectral domain optic coherence tomography (SD-OCT), in patients with vitamin A deficiency have previously not been documented. Read More

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http://dx.doi.org/10.1186/s40942-020-00224-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275575PMC

Vitamin C deficiency mimicking inflammatory bone disease of the hand.

Pediatr Rheumatol Online J 2020 Jun 9;18(1):45. Epub 2020 Jun 9.

Division of Rheumatology, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.

Background: Severe vitamin C deficiency, or scurvy, encompasses a syndrome of multisystem abnormalities due to defective collagen synthesis and antioxidative functions. Among the more common presentations is a combination of oral or subcutaneous hemorrhage with lower extremity pain, the latter often exhibiting inflammatory bone changes on magnetic resonance imaging (MRI).

Case Presentation: A 12-year-old male with anorexia nervosa presented with asymmetric painful swelling of multiple fingers of both hands. Read More

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http://dx.doi.org/10.1186/s12969-020-00439-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285567PMC

A Prospective Multicenter Study on the Prevalence of Fructose Malabsorption in Patients with Chronic Inflammatory Bowel Disease.

Digestion 2020 Jun 9:1-7. Epub 2020 Jun 9.

Department of Internal and Integrative Medicine, Klinikum Bamberg, Bamberg, Germany.

Background And Aims: Patients with chronic inflammatory bowel disease (IBD) might have a higher prevalence of fructose malabsorption than healthy controls. This study's aim was to determine the prevalence and symptom severity of fructose malabsorption in patients with active and inactive IBD.

Methods: The present study was a multicenter noninterventional diagnostic pilot trial. Read More

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http://dx.doi.org/10.1159/000507851DOI Listing

Alcohol use disorder and the gut.

Addiction 2020 Jun 8. Epub 2020 Jun 8.

Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia.

Acute and chronic gastrointestinal problems are common in the setting of excessive alcohol use, and excessive alcohol use is associated with injury to all parts of the gastrointestinal tract. There is mounting evidence of gastrointestinal injury and increased cancer risk even from moderate alcohol consumption. The major causes of alcohol-related morbidity and mortality within the gastrointestinal system are liver disease, pancreatitis and gastrointestinal cancer. Read More

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http://dx.doi.org/10.1111/add.15147DOI Listing

[Iron metabolism and iron-refractory iron deficiency anemia].

Authors:
Takahiro Suzuki

Rinsho Ketsueki 2020 ;61(5):475-483

Department of Hematology, Kitasato University School of Medicine.

Hepcidin is a key molecule that regulates iron metabolism in the body. Iron refractory iron deficiency anemia (IRIDA) is a genetic disorder caused by a defect in the TMPRSS6 gene encoding matriptase-2, a transmembrane serine protease that physiologically inhibits hepcidin production. In patients with IRIDA, the iron uptake in the intestine is remarkably reduced, and iron deficiency anemia (IDA) develops. Read More

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http://dx.doi.org/10.11406/rinketsu.61.475DOI Listing
January 2020

Lower gastrointestinal bleeding due to colonic fistula caused by a gossypiboma: Case report and literature review.

Int J Surg Case Rep 2020 May 29;72:59-62. Epub 2020 May 29.

Department of General and Digestive Surgery, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Universitat Autonoma de Barcelona, Spain.

Introduction: Even in modern surgery, human mistakes cannot be totally avoided. Retained surgical items are among the most feared ones. Forgotten sponges inside patients can cause a wide range of complications due to the foreign body reaction, called gossypiboma. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283079PMC

Maldigestion Versus Malabsorption in the Elderly.

Curr Gastroenterol Rep 2020 Jun 4;22(7):33. Epub 2020 Jun 4.

Baylor University Medical Center, 260 Wadley Tower, 3500 Gaston Avenue, Dallas, TX, 75246, USA.

Purpose Of Review: To evaluate recently published information about the frequency of maldigestion and malabsorption in older individuals, likely diagnoses causing these problems, and the diagnostic scheme when these diagnoses are being considered.

Recent Findings: Although the prevalence of malnourishment and frank malnutrition may be increasing among older adults admitted to the hospital, this appears to be due to reduced food intake rather than maldigestion or malabsorption. The mechanisms of food digestion and absorption seem to be resilient, even in old age, but concurrent illness may produce malabsorption in older individuals. Read More

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http://dx.doi.org/10.1007/s11894-020-00771-5DOI Listing

A rare cause of nephrocalcinosis in an infant: Answers.

Pediatr Nephrol 2020 Jun 4. Epub 2020 Jun 4.

Pediatric Gastroenterology, Hepatology and Nutrition Unit, Division of Pediatrics, Hospital Regional Universitario de Málaga, Málaga, Spain.

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http://dx.doi.org/10.1007/s00467-020-04615-2DOI Listing

Vitamin K supplementation for cystic fibrosis.

Cochrane Database Syst Rev 2020 06 4;6:CD008482. Epub 2020 Jun 4.

Research and Development, Empower 2 Go, Edmonton, UK.

Background: Malabsorption and deficiency of fat-soluble vitamins K may occur in cystic fibrosis, a genetic disorder affecting multiple organs. Vitamin K is known to play an important role in both blood coagulation and bone formation, hence the role of supplementation of vitamin K in this category needs to be reviewed. This is an updated version of the review. Read More

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http://dx.doi.org/10.1002/14651858.CD008482.pub6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272115PMC

Food intolerance/malabsorption may occur in rare diseases.

Intractable Rare Dis Res 2020 May;9(2):126-129

Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Auenbruggerplatz 30, Graz, Austria.

Sugars including lactose and fructose, or proteins (gluten), or biogenic amines (histamine), and combinations thereof may cause food intolerance/malabsorption. However, in usually asymptomatic patients with rare diseases, who present with functional, non-specific, non-allergic gastrointestinal (GI) complaints the etiologic factors of food intolerance/malabsorption need to be evaluated. We summarize patients with rare diseases, such as primary epiploic appendagitis, beta-thalassemias minor, Gullo syndrome and anomaly of the inferior vena cava, who presented functional, non-specific, non-allergic GI complaints. Read More

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http://dx.doi.org/10.5582/irdr.2020.01029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263995PMC

A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 3;21(1):466. Epub 2020 Jun 3.

Clinical Pharmacology Department, Clinical Trial Unit, La Paz University Hospital - IdiPAZ, Paseo de la Castellana, 261, 28046, Madrid, Spain.

Objectives: Primary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure. Secondary objectives: To evaluate the efficacy of melatonin as a prophylactic treatment on prevention of asymptomatic SARS-CoV-2 infection.To evaluate the efficacy of melatonin to prevent the development of severe COVID-19 in the participants enrolled in this study who develop SARS-CoV-2 infection along the trial. Read More

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http://dx.doi.org/10.1186/s13063-020-04436-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267766PMC

Nutritional Status and Bone Microarchitecture in a Cohort of Systemic Sclerosis Patients.

Nutrients 2020 Jun 1;12(6). Epub 2020 Jun 1.

Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine DiMI, University of Genoa, IRCCS San Martino Polyclinic, 16126 Genoa, Italy.

Systemic sclerosis (SSc) is a connective tissue disease characterized by initial microvascular damage, immune system activation and progressive fibrosis with insufficiency of internal organs. Gastrointestinal (GI) involvement is characterized by atrophy of the smooth muscle and small bowel hypomotility, mainly resulting from an autonomic nerve dysfunction. These modifications significantly affect gut transit and nutrient absorption, thus leading to malnutrition deficit induced by malabsorption. Read More

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http://dx.doi.org/10.3390/nu12061632DOI Listing