46,919 results match your criteria Malabsorption

Expression of the fructose transporter GLUT5 in patients with fructose malabsorption.

Z Gastroenterol 2021 Jun 15;59(6):531-539. Epub 2021 Jun 15.

Specialist Practice for Internal Medicine, Oldenburg, Oldenburg Germany.

Background:  Patients with abdominal symptoms are frequently diagnosed with fructose malabsorption (FM). Fructose is absorbed by monosaccharide transporters located in the brush border of the human small intestine. The aim of this study was to investigate the histoanatomical distribution of the main fructose transporter GLUT5. Read More

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Immunosuppression does not prevent severe gastrointestinal tract involvement in systemic sclerosis.

Clin Exp Rheumatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, McGill University, Montreal, Quebec; Division of Rheumatology, Jewish General Hospital, Montreal, Quebec, and Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.

Objectives: We aimed to test the hypothesis that exposure to immunosuppression in early systemic sclerosis (SSc) could modify the risk of developing new onset severe gastrointestinal (GIT) involvement.

Methods: A total of 762 subjects with <3 years of disease duration and without severe GIT disease at baseline study visit were identified from combined longitudinal cohort data from the Canadian Scleroderma Research Group (CSRG) and Australian Scleroderma Interest Group (ASIG). The primary exposure was ever use of methotrexate, cyclophosphamide, mycophenolate mofetil and/or azathioprine during the study period. Read More

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A Rare Case of Exocrine Pancreatic Insufficiency.

Eur J Case Rep Intern Med 2021 18;8(5):002556. Epub 2021 May 18.

Emergency Radiology Department, Ibn Rochd University Hospital, Faculty of Medicine and Pharmacy of Casablanca, Morocco.

Lipomatous pseudohypertrophy (LPH) of the pancreas is an uncommon affection of exocrine pancreatic insufficiency. It is defined as substitution of the pancreatic exocrine gland by a large fat component. We report the case of a young patient with malabsorption syndrome (chronic diarrhoea and steatorrhoea), abnormal laboratory results and normal fibroscopy. Read More

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Decreased Expression of Ileal Thyroid Hormone Transporters in a Hypothyroid Patient: A Case Report.

Front Endocrinol (Lausanne) 2021 26;12:664839. Epub 2021 May 26.

Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.

Background: Malabsorption of levothyroxine (LT4) is a common problem faced in clinical practice. It is usually solved, if there are no complexities including gastrointestinal absorption disorder, by taking medicines on an empty stomach and avoiding foods interfering with LT4. Herein we present a rare case of a patient exhibiting malabsorption of LT4 with decreased membranous expression of ileal transporters. Read More

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Altered tryptophan absorption and metabolism could underlie long-term symptoms in survivors of coronavirus disease 2019 (COVID-19).

Nutrition 2021 May 1;90:111308. Epub 2021 May 1.

Department of General Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

The global pandemic of COVID-19 has been lasting for more than one year and there is little known about the long-term health effects of the disease. Long-COVID is a new term that is used to describe the enduring symptoms of COVID-19 survivors. Huang et al. Read More

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Serum iPTH range in a reference population: From an integrated approach to vitamin D prevalence impact evaluation.

Clin Chim Acta 2021 Jun 8;521:1-8. Epub 2021 Jun 8.

Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy; Unit of Laboratory Medicine, Tor Vergata University Hospital, Rome, Italy.

Background: The iPTH upper reference limit (URL) reported by our laboratory provider (Abbott Laboratories) at Tor Vergata University Hospital was evaluated by internal verification procedures as not representative of our population and resulting as underestimated. In this study, a new reference interval has been investigated and established by comparing a direct and an indirect method based on a statistical reduction from results stored in the laboratory database.

Methods: For reference interval calculation from the healthy population, we analyzed a cohort of 100 blood donors (84% males and 16% females) screened with no bone-related and malabsorption diseases. Read More

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The safety of available treatment options for short bowel syndrome and unmet needs.

Expert Opin Drug Saf 2021 Jun 19:1-13. Epub 2021 Jun 19.

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Centre for Chronic Intestinal Failure - Clinical Nutrition and Metabolism Unit, Italy.

Introduction: Short bowel syndrome (SBS) is a rare, highly disabling, life-threatening condition due to extensive intestinal resections, characterized by diarrhea, malabsorption, and malnutrition. SBS is the main cause of intestinal failure (SBS-IF). The primary therapy for SBS-IF is intravenous supplementation (IVS) of nutrients. Read More

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An examination of gastrointestinal absorption using the acetaminophen absorption test in critically ill patients with COVID-19: A retrospective cohort study.

Nutr Clin Pract 2021 Jun 8. Epub 2021 Jun 8.

Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Objective: Gastrointestinal (GI) dysfunction is prevalent in critically ill patients with coronavirus disease 2019 (COVID-19). The acetaminophen absorption test (AAT) has been previously described as a direct method for assessment of GI function. Our study determines whether the AAT can be used to assess GI function in critically ill COVID-19 patients, compared with traditional measures of GI function. Read More

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Levothyroxine sodium oral solution to control thyroid function in a patient with hypothyroidism and celiac disease.

Ernest Asamoah

Clin Case Rep 2021 May 28;9(5):e04170. Epub 2021 May 28.

Diabetes & Endocrinology Care Community Physicians Network Indianapolis IN USA.

Implementing a gluten-free diet and switching to the levothyroxine oral solution significantly improved malabsorptive and hypothyroid symptoms in a patient with hypothyroidism, Addison's disease, and celiac disease without the need to increase levothyroxine dosage. Read More

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Understanding celiac disease monitoring patterns and outcomes after diagnosis: A multinational, retrospective chart review study.

World J Gastroenterol 2021 May;27(20):2603-2614

Takeda Pharmaceuticals International Co., Cambridge, MA 02139, United States.

Background: Long-term outcomes and monitoring patterns in real-world practice are largely unknown among patients with celiac disease.

Aim: To understand patterns of follow-up and management of patients with celiac disease, and to characterize symptoms and villous atrophy after diagnosis.

Methods: A retrospective chart review study was performed using medical chart data of patients diagnosed with celiac disease. Read More

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The impact of a gluten-free diet on the growth pattern of Saudi children with coeliac disease.

J Pak Med Assoc 2021 May;71(5):1388-1393

Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Saudi Arabia.

Objective: To assess the growth pattern of children with coeliac disease after the introduction of a gluten-free diet.

Method: The retrospective study was conducted at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, and comprised data from January 2015 to December 2018 of children aged 2-16 years with biopsy-proven coeliac disease. Serial measurements of height-for-age and weight-for-age z-scores were recorded at 0, 4, 8, 12 and 16 months. Read More

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Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: A Thesis* Questionnaire Survey of Romanian Physicians *Thesis: Treatment of Hypothyroidism in Europe by Specialists: an International Survey.

Acta Endocrinol (Buchar) 2020 Oct-Dec;16(4):462-469

"Carol Davila" University of Medicine and Pharmacy - Endocrinology, Bucharest, Romania.

Objective: Romania has no national guidelines for hypothyroidism treatment, nor are there any recommendations from national societies to adhere to international guidelines. Our aim was to identify the attitudes of Romanian physicians relating to hypothyroidism treatment focusing on available formulations of levothyroxine (LT4).

Methods: All 748 members of the Romanian Society of Endocrinology were invited to participate in a web-based survey. Read More

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Epidemiology and burden of progressive familial intrahepatic cholestasis: a systematic review.

Orphanet J Rare Dis 2021 Jun 3;16(1):255. Epub 2021 Jun 3.

, Roboleo & Co, Leeds, UK.

Background: Progressive familial intrahepatic cholestasis is a rare, heterogeneous group of liver disorders of autosomal recessive inheritance, characterised by an early onset of cholestasis with pruritus and malabsorption, which rapidly progresses, eventually culminating in liver failure. For children and their parents, PFIC is an extremely distressing disease. Significant pruritus can lead to severe cutaneous mutilation and may affect many activities of daily living through loss of sleep, irritability, poor attention, and impaired school performance. Read More

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Abetalipoproteinemia Due to a Novel Splicing Variant in in 3 Siblings.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211022484

Western University, London, Ontario, Canada.

Abetalipoproteinemia (ABL) is a rare recessive condition caused by biallelic loss-of-function mutations in the gene encoding the microsomal triglyceride transfer protein large subunit. ABL is characterized by absence of apolipoprotein B-containing lipoproteins and deficiencies in fat-soluble vitamins leading to multisystem involvement of which neurological complications are the most serious. We present 3 siblings with ABL who were born to non-consanguineous parents of Filipino and Chinese background. Read More

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Approach to the adult patient with chronic diarrhea: a literature review.

Rev Gastroenterol Mex 2021 May 29. Epub 2021 May 29.

Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Veracruz, México.

Chronic diarrhea is defined by symptoms lasting longer than 4 weeks. It is a common problem that affects up to 5% of the adult population. Different pathophysiologic mechanisms involve numerous causes, including drug side effects, postoperative anatomic and physiologic alterations, intestinal and colonic wall abnormalities, inflammatory or malabsorption causes, pancreatobiliary diseases, and functional or gut-brain axis disorders associated with dysbiosis or gastrointestinal motility alterations. Read More

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Non-Celiac Gluten Sensitivity: An Update.

Medicina (Kaunas) 2021 May 24;57(6). Epub 2021 May 24.

Clinical and Research Laboratory (LACIUS, URS), Department of Chemical, Biological, and Agricultural Sciences (DC-QB), Division of Sciences and Engineering, University of Sonora, Navojoa 85880, Mexico.

Non-celiac gluten sensitivity (NCGS) is a clinical entity characterized by the absence of celiac disease and wheat allergy in patients that trigger reproducible symptomatic responses to gluten-containing foods consumption. Due to the lack of sensitive and reproducible biomarkers for NCGS diagnosis, placebo-controlled gluten challenges must be carried out for its diagnosis. The gluten challenges can be either double- or single-blind, for research or clinical practice purposes, respectively. Read More

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Pandemic Effects and Gluten-Free Diet: An Adherence and Mental Health Problem.

Nutrients 2021 May 27;13(6). Epub 2021 May 27.

Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago 7810000, Chile.

The COVID-19 pandemic has been present for many months, influencing diets such as the gluten-free diet (GFD), which implies daily challenges even in non-pandemic conditions. Persons following the GFD were invited to answer online ad hoc and validated questionnaires characterizing self-perceptions of the pandemic, current clinical condition, dietary characteristics, adherence to GFD, anxiety, and depression. Of 331 participants, 87% experienced shortage and higher cost of food and 14. Read More

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Blinded Oral Challenges with Lactose and Placebo Accurately Diagnose Lactose Intolerance: A Real-Life Study.

Nutrients 2021 May 13;13(5). Epub 2021 May 13.

Department of Clinical Medicine and Surgery, Gastroenterology, University Federico II of Naples, 80131 Naples, Italy.

Lactose intolerance (LI) is characterized by diarrhea, abdominal pain, or bloating occurring after lactose consumption in patients with lactose malabsorption. The National Institute of Health (NIH) proposed a double-blind placebo testing to identify LI individuals correctly. However, until now, no study used this approach in a real-life setting. Read More

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Impact of Liver and Pancreas Diseases on Nutritional Status.

Nutrients 2021 May 13;13(5). Epub 2021 May 13.

Unidad de Gastroenterología, Hepatología y Nutrición, Hospital Universitario San Jorge, 22004 Huesca, Spain.

Liver and pancreatic diseases have significant consequences on nutritional status, with direct effects on clinical outcomes, survival, and quality of life. Maintaining and preserving an adequate nutritional status is crucial and should be one of the goals of patients with liver or pancreatic disease. Thus, the nutritional status of such patients should be systematically assessed at follow-up. Read More

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Baseline Levels of Vitamin D in a Healthy Population from a Region with High Solar Irradiation.

Nutrients 2021 May 13;13(5). Epub 2021 May 13.

Servicio de Reumatología, Hospital Universitario de Canarias, 38320 La Laguna, Spain.

The use of vitamin D (VitD) supplements has become widespread in the last decade due not only to the dissociation between the blood levels recommended as "optimal" and those shown by the healthy population but also to its presumed beneficial effects on multiple disorders. This work evaluated the levels of 25-hydroxyvitamin D (25(OH)D) in a healthy population of European origin living in a region with high solar irradiation. In serum samples from a population-based study conducted in the Canary Islands, levels of 25(OH)D were analyzed. Read More

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Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature.

Nutrients 2021 May 22;13(6). Epub 2021 May 22.

General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy.

Total pancreatectomy (TP) is a highly invasive procedure often performed in patients affected by anorexia, malabsorption, cachexia, and malnutrition, which are risk factors for bad surgical outcome and even may cause enhanced toxicity to chemo-radiotherapy. The role of nutritional therapies and the association between nutritional aspects and the outcome of patients who have undergone TP is described in some studies. The aim of this comprehensive review is to summarize the available recent evidence about the influence of nutritional factors in TP. Read More

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Health-Related Quality of Life and Experiences of Brazilian Celiac Individuals over the Course of the Sars-Cov-2 Pandemic.

Nutrients 2021 May 9;13(5). Epub 2021 May 9.

Department of Nutrition, School of Health Sciences, University of Brasilia, 70910-900 Brasilia, Brazil.

Since the end of 2019, the world has been facing an unpredicted COVID-19 pandemic with consequences for the economy, environment, society, and health. The COVID-19 pandemic has increased the risk of death, bringing unbearable psychological pressure upon people worldwide. For celiac patients, the pandemic may represent an additional burden concerning the inherent aspects of celiac disease (CD) that compromise these individuals' quality of life (QoL). Read More

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Peripheral T-Cell Lymphoma Possibly Due to Unrecognized Celiac Disease in an Elderly Patient: A Case Report.

Medicina (Kaunas) 2021 May 11;57(5). Epub 2021 May 11.

Department of Internal Diseases, Metabolic Disorders and Hypertension, Poznań University of Medical Sciences, Szamarzewskiego 84, 60-569 Poznań, Poland.

Celiac disease (CD) is widely perceived as a childhood disorder. However, it has been demonstrated that 19-34% of new CD cases are diagnosed in patients over 60 years of age and lack the typical presentation. A 76-year-old female was admitted to the clinic due to a recurrent fever that had lasted over a year accompanied by progressive weakness, weight loss of about 10 kg, dehydration, and malnutrition. Read More

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Celiac Disease and the Thyroid: Highlighting the Roles of Vitamin D and Iron.

Nutrients 2021 May 21;13(6). Epub 2021 May 21.

Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.

Celiac disease (CD) and autoimmune thyroid diseases (AITD) like Hashimoto's thyroiditis (HT) and Graves' disease (GD) frequently coexist, entailing numerous potential impacts on diagnostic and therapeutic approaches. Possible correlations might exist through gut microbiota, regulating the immune system and inflammatory responses, promoting autoimmune diseases, as well as shared cytokines in pathogenesis pathways, cross-reacting antibodies or malabsorption of micronutrients that are essential for the thyroid like iron or vitamin D. Vitamin D deficiency is a common finding in patients with AITD, but might protect from autoimmunity by wielding immunoregulatory and tolerogenic impacts. Read More

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Third reported case of rare necrolytic migratory erythema associated with bacteraemia due to severe zinc deficiency after revisional Roux-En-Y gastric bypass: case report and literature review.

Eat Weight Disord 2021 Jun 1. Epub 2021 Jun 1.

Department of Bariatric Surgery/Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, State of Qatar.

Introduction: Obesity is a risk factor for zinc deficiency. After bariatric surgery, non-compliance to diet/vitamin supplements, surgical complications leading to vomiting/diarrhea, poor follow-up and malabsorption can precipitate or exacerbate pre-existing zinc deficiency.

Case Report: We report a patient with rare necrolytic migratory erythema associated with bacteraemia due to severe zinc deficiency after revisional Roux-en-Y gastric bypass (following primary laparoscopic sleeve gastrectomy). Read More

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Lymphocytic gastritis and celiac disease.

Pol J Pathol 2021 ;72(1):87-88

Gastroenterology Unit. Department of Life, Health and Environmental Sciences. University of L'Aquila, L'Aquila, Italy.

We read with great interest the review article "Lymphocytic gastritis" by Puderecki et al., which was recently published in your journal [1]. The article describes the features of lymphocytic gastritis (LG), a rare form of gastritis with unclear pathogenesis. Read More

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[Serological screening and analysis of clinical characteristics for celiac disease in susceptible population in Southern China].

Zhonghua Nei Ke Za Zhi 2021 Jun;60(6):539-543

Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

To determine the seroprevalence of celiac disease in susceptible population, and to analyze the relationship between demographic characteristics, dietary habits, lifestyle and serological positivity so as to provide guidance for the prevention and treatment of celiac disease in Southern China. A total of 1 273 individuals who participated in Guangdong Province Health Screening Program in 2015, were selected as serologically positive subjects of celiac disease, including people with irritable bowel syndrome, colitis, diarrhea, anemia, low BMI, short stature, type 1 diabetes mellitus (T1DM), rheumatoid arthritis (RA), ankylosing spondylitis, psoriasis and bristol grade=6 or 7. All subjects were tested for serum IgA anti-tissue transglutaminase antibodies (TTGA), IgA antibodies against deamidated gliadin peptides(DGPA) and IgG against deamidated gliadin peptides (DGPG). Read More

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A 17-Month-old Boy With Pancytopenia Caused by a Rare Genetic Defect of Vitamin B12 Malabsorption.

J Pediatr Hematol Oncol 2021 May 31. Epub 2021 May 31.

Departments of Pediatrics Pathology Pediatrics and Prevention Genetics LLC Pediatric Hematology-Oncology Pediatric Intensive Care Unit, Marshfield Children's Hospital, Marshfield Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Imerslund-Gräsbeck syndrome is an autosomal recessive disorder of vitamin B12 malabsorption presenting with megaloblastic anemia and mild proteinuria in childhood. The disorder is caused by biallelic pathogenic variants in the CUBN or AMN genes, which encode proteins involved in B12 absorption. We present the case of a 17-month-old boy with failure to thrive, pancytopenia, and fevers. Read More

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