48,569 results match your criteria Malabsorption

Is anemia frequently recognized in gastroschisis compared to omphalocele? A multicenter retrospective study in southern Japan.

Pediatr Surg Int 2022 Jun 28. Epub 2022 Jun 28.

Department of Pediatric Surgery, Research Field in Medical and Health Sciences, Medical and Dental Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.

Purpose: We compared cases of anemia in gastroschisis versus omphalocele and investigated this clinical question.

Methods: A multicenter study of five pediatric surgery departments in southern Japan was planned. Sixty patients were collected between 2011 and 2020, with 33 (gastroschisis: n = 19, omphalocele: n = 14) who met the selection criteria ultimately being enrolled. Read More

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Single Anastomosis Jejuno-ileal (SAJI): a New Model of Malabsorptive Revisional Procedure for Insufficient Weight Loss or Weight Regain After Roux-en-Y Gastric Bypass.

Obes Surg 2022 Jun 28. Epub 2022 Jun 28.

Metabolic & Obesity Unit, Chirec Delta Hospital, Brussels, Belgium.

Background: In case of insufficient weight loss or weight regain or relapse of weight-related comorbidities after Roux-en-Y gastric bypass (RYGB), other procedures such as reduction of a large gastric pouch and stoma, lengthening of the Roux limb, conversion to sleeve gastrectomy and/or bilio-pancreatic diversion with duodenal switch have been advocated. Single anastomosis jejuno-ileal (SAJI) is a new revisional simple operation performed after RYGB failure which adds malabsorption to the previous gastric bypass.

Methods: SAJI includes a single jejuno-ileal anastomosis specifically joining the ileum 250-300 cm proximal to the ileo-caecal valve and the jejunum 30 cm below the gastro-jejunal anastomosis on the Roux limb of the previous RYGB. Read More

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Complementary food introduction practices in infants with intestinal failure.

Nutr Clin Pract 2022 Jun 28. Epub 2022 Jun 28.

Department of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Background: Oral intake in infants with intestinal failure (IF) may be limited due to intolerance or feeding difficulties. Guidelines for the introduction of semisolid or solid complementary foods (CFs) to infants with IF do not exist. CF intake and caloric contribution from CF is difficult to assess due to malabsorption and incomplete recording. Read More

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[The malabsorption of levothyroxine: a kaleidoscope of comorbidities?]

Camilla Virili

Recenti Prog Med 2022 Jun;113(6):15e-18e

Oral levothyroxine treatment appears to be easy to manage but the hormone absorption can be impaired by several interfering factors, leading to abnormal TSH levels. Therefore, patients can be at risk of both under and over treatment. A 41 years old woman came to our attention for Hashimoto's thyroiditis with refractory hypothyroidism and a malabsorption has been suspected. Read More

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Spectrum of chronic gastrointestinal diseases with final outcome in children at a tertiary care centre: A single-centre study.

J Pak Med Assoc 2022 Jun;72(6):1188-1192

Department of Anaesthesia, Pakistan Kidney and Liver Institute and Research Centre, Lahore, Pakistan.

Chronic gastrointestinal (GI) diseases in children present with a wide range of symptoms. Limited resources in Paediatric Gastroenterology in developing countries like Pakistan cause considerable difficulties in managing children with chronic GI diseases in a timely fashion. This retrospective descriptive study aimed to determine the spectrum and outcomes of chronic GI diseases in children. Read More

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Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study.

Biogerontology 2022 Jun 24. Epub 2022 Jun 24.

Laboratory of Aging Physiology and Molecular Evolution, Biology Department, Ghent University, Ghent, Belgium.

To find drivers of healthy ageing, a genome-wide association study (GWAS) was performed in healthy and unhealthy older individuals. Healthy individuals were defined as free from cardiovascular disease, stroke, heart failure, major adverse cardiovascular event, diabetes, dementia, cancer, chronic obstructive pulmonary disease (COPD), asthma, rheumatism, Crohn's disease, malabsorption or kidney disease. Six single nucleotide polymorphisms (SNPs) with unknown function associated with ten human genes were identified as candidate healthspan markers. Read More

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Letter: progressive weakening of the concept that gluten has a detrimental effect on mental health and gut symptoms in the absence of coeliac disease.

Aliment Pharmacol Ther 2022 Jul;56(2):363-364

Department of Gastroenterology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

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Editorial: lack of gastrointestinal symptoms caused by gluten in patients without coeliac disease-time to ditch the 'gluten' from 'non-coeliac gluten sensitivity'.

Jason A Tye-Din

Aliment Pharmacol Ther 2022 Jul;56(2):340-341

Immunology Division, The Walter and Eliza Hall Institute, Parkville, Victoria, Australia.

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Systemic amyloidosis as a cause of chronic diarrhea after gastric surgery. Literature review.

Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

Cirugía General y del Aparato Digestivo, Hospital Universitario Clínico San Cecilio, España.

Amyloidosis with gastrointestinal involvement is a rare cause of chronic diarrhoea, and should be considered especially in adult patients with intestinal malabsorption and extra GI manifestations. We present the case of a male patient who, after an oncological gastrectomy, presented with chronic diarrhea that did not respond to treatment and, after study, the cause of the diarrhea was finally found. Primary systemic light chain amyloidosis (AL) initially presents as chronic diarrhea and weight loss after gastrectomy. Read More

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Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study.

Nutrients 2022 Jun 15;14(12). Epub 2022 Jun 15.

Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55907, USA.

Histological changes induced by gluten in the duodenal mucosa of patients with non-coeliac gluten sensitivity (NCGS) are poorly defined. To evaluate the structural and inflammatory features of NCGS compared to controls and coeliac disease (CeD) with milder enteropathy (Marsh I-II). Well-oriented biopsies of 262 control cases with normal gastroscopy and histologic findings, 261 CeD, and 175 NCGS biopsies from 9 contributing countries were examined. Read More

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Adherence to Gluten-Free Diet Restores Alpha Diversity in Celiac People but the Microbiome Composition Is Different to Healthy People.

Nutrients 2022 Jun 14;14(12). Epub 2022 Jun 14.

Department of Agriculture, Food, Natural Resources and Engineering (DAFNE), University of Foggia, 71122 Foggia, Italy.

Celiac disease (CD) is an autoimmune disease with the destruction of small intestinal villi, which occurs in genetically predisposed individuals. At the present moment, a gluten-free diet (GFD) is the only way to restore the functionality of gut mucosa. However, there is an open debate on the effects of long-term supplementation through a GFD, because some authors report an unbalance in microbial taxa composition. Read More

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[Vein of Galen aneurysmal malformation].

Radiologie (Heidelb) 2022 Jun 23. Epub 2022 Jun 23.

Klinik für Diagnostische und Interventionelle Neuroradiologie, Klinikum Bremen-Mitte/Bremen-Ost, 28205, Bremen, Deutschland.

The vein of Galen aneurysmal malformation (VGAM) is a rare aneurysmatic cerebrovascular malformation in newborns and children. The VGAM results from an arteriovenous fistula between the persistent vein of Markowski (embryonic precursor of the vein of Galen) and deep choroidal arteries. The VGAM is the most common noncardiac cause of high-output cardiac failure in newborns. Read More

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[Pediatric Intestinal Failure, 10 years of experience from a specialized unit].

Andes Pediatr 2022 Apr;93(2):192-198

Hospital San Juan de Dios, Santiago, Chile.

Intestinal Failure (IF) includes the loss of functional intestinal mass and the requirement of long term Parenteral Nutrition (PN) to achieve the development and growth in childhood.

Objective: To evaluate the experience in a specialized unit for pediatric patients with IF, describing the clinical cha racteristics of those admitted from November 2009 to December 2019.

Patients And Method: Retros pective and descriptive review from clinical records of 24 cases that matched the inclusion criteria. Read More

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Liposoluble vitamins A and E in kidney disease.

World J Nephrol 2022 May;11(3):96-104

Department of Renal Medicine, Nutrition School, Universidad Autónoma de Querétaro, Querétaro 76090, Mexico.

Kidney disease (KD) is characterized by the presence of elevated oxidative stress, and this is postulated as contributing to the high cardiovascular morbidity and mortality in these individuals. Chronic KD (CKD) is related to high grade inflammatory condition and pro-oxidative state that aggravates the progression of the disease by damaging primary podocytes. Liposoluble vitamins (vitamin A and E) are potent dietary antioxidants that have also anti-inflammatory and antiapoptotic functions. Read More

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Severe small intestinal bacterial overgrowth syndrome after jejunal feeding requiring surgical intervention: a case report and review of the literature.

BMC Gastroenterol 2022 Jun 20;22(1):300. Epub 2022 Jun 20.

Department of Surgery, Valleywise Health Medical Center, Phoenix, AZ, USA.

Background: Small intestinal bacterial overgrowth (SIBO) is a condition of unknown prevalence characterized by an excessive amount of bacteria in the small bowel, typically resulting in vague gastrointestinal symptoms with bloating being most commonly reported. Here we describe a severe case of SIBO leading to small bowel necrosis requiring surgical intervention.

Case Presentation: A 55-year-old Hispanic female with gastric outlet obstruction secondary to a newly diagnosed gastric adenocarcinoma, receiving neoadjuvant chemotherapy, developed bloody gastrostomy output and rapidly progressing nausea and abdominal distention 3 days after jejunostomy tube placement and initiation of jejunal enteral nutrition. Read More

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Management of pediatric intestinal failure related to short bowel syndrome.

Semin Pediatr Surg 2022 Jun 14;31(3):151175. Epub 2022 May 14.

Division of General and Thoracic Surgery, Cincinatti Children's Hospital Medical Center, University of Cincinnati, Cincinnatii, USA; Cincinnati Children's Intestinal Rehabilitation Program, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, MLC 2023, Cincinnati, Ohio 45229, USA. Electronic address:

Intestinal failure (IF) secondary to short bowel syndrome is a challenging and complex medical condition with significant risk for surgical and medical complications. Significant advancements in the care of this patient population have led to improved survival rates. Due to their intensive medical needs children with IF are at risk for long-term complications that require comprehensive management and close monitoring. Read More

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The role of methylenetetrahydrofolate reductase C677T gene polymorphism as a risk factor for coronary artery disease: a cross-sectional study in the Sidoarjo Regional General Hospital.

Pan Afr Med J 2022 15;41:212. Epub 2022 Mar 15.

Cardiology and Vascular Medicine Department, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.

Introduction: hyperhomocysteinemia (HHcy) may contribute to an increased risk of coronary artery disease (CAD). The underlying mechanisms are not well understood, but other than dietary intake factors, hyperhomocysteinemia may genetically result from a methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism. A cross-sectional study was performed to assess whether this mutation was a potential genetic risk factor for CAD. Read More

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An apparent primitive mass of the mesentery: A case report.

Medicine (Baltimore) 2022 Jun 17;101(24):e29464. Epub 2022 Jun 17.

General Surgery Department, IRCCS MultiMedica, Italy.

Introduction: Neuroendocrine tumours (NETs) are rare tumors. 55% of NETs originate in the gastrointestinal tract and the liver is the most common site of distant metastases. Serum chromogranin A is the most common biomarker for assessing the extent of disease and monitoring treatment; carcinoid syndrome occurs in 19% of NETs and is characterized by chronic diarrhea or flushing. Read More

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Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients.

Cell Rep 2022 Jun;39(11):110956

Departement of Oncology, UNIL-CHUV, Ludwig Institute for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland. Electronic address:

Celiac disease (CD) is a multisystem disease in which different organs may be affected. We investigate whether circulating innate lymphoid cells (ILCs) contribute to the CD peripheral inflammatory status. We find that the CD cytokine profile is characterized by high concentrations of IL-12p40, IL-18, and IFN-γ, paralleled by an expansion of ILC precursors (ILCPs). Read More

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Ashford, Bananas, and Celiac Disease.

Alan Preston

P R Health Sci J 2022 Jun;41(2):2965

Department of Biochemistry, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.

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Letter to the Editor for the article "20-year follow-up study of celiac patients identified in a mass school screening: compliance to gluten-free diet and autoimmunity".

J Pediatr Gastroenterol Nutr 2022 Apr 2;74(4):e101. Epub 2021 Nov 2.

Tampere Center for Child, Adolescent and Maternal Health Research, Tampere University and Department of Pediatrics, Tampere University Hospital.

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Modification of baseline status to improve breath tests performance.

Sci Rep 2022 Jun 13;12(1):9752. Epub 2022 Jun 13.

Clínica Universidad de Navarra (Service of Biochemistry), Av. Pío XII 36, 31008, Pamplona, Spain.

Breath tests used to evaluate carbohydrates malabsorption require baseline H and CH levels as low as possible. Test cancellation is recommended when exceeding certain cut-offs (H ≥ 20 ppm and CH ≥ 10 ppm). Although following preparation protocols, many patients have baseline levels above those cut-offs. Read More

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HLA Genotyping in Romanian Adult Patients with Celiac Disease, their First-degree Relatives and Healthy Persons.

J Gastrointestin Liver Dis 2022 Jun 12;31(2):191-197. Epub 2022 Jun 12.

Carol Davila University of Medicine and Pharmacy, Centre of Immunogenetics and Virology, Clinical Fundeni Institute, Bucharest, Romania.

Background And Aims: Celiac disease is characterized by an inappropriate T-cell-mediated response to gluten in small bowel in genetically predisposed individuals, carriers of the DQ2 and/or DQ8 haplotypes of the human leukocyte antigen. The aim of our study was to asses HLA typing in adult patients with celiac disease, in their first degree relatives and in a healthy control group.

Methods: We conducted a prospective observational study on three cohorts: 117 patients diagnosed with celiac disease, 41 first-degree relatives of celiac patients and 57 asymptomatic healthy volunteers. Read More

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Artesunate and dihydroartemisinin-piperaquine treatment failure in a severe Plasmodium falciparum malaria case imported from Republic of Côte d'Ivoire.

Int J Infect Dis 2022 Jun 9;122:352-355. Epub 2022 Jun 9.

Dipartimento di Ricerca Traslazionale e Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa, Pisa, Italy; Sezione Dipartimentale di Microbiologia Universitaria, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy. Electronic address:

A 68-year-old man returning from Republic of Côte d'Ivoire (Ivory Coast) was diagnosed with severe Plasmodium falciparum malaria and treated with intravenous artesunate followed by oral dihydroartemisinin-piperaquine (DHA-PPQ). A month later the patient experienced a new P. falciparum episode; analysis of pfmsp-1 and pfmsp-2 revealed that the infection was caused by a genetic strain identical to the strain that caused the initial episode, indicating resurgence of the previous infection. Read More

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Coeliac disease.

Lancet 2022 06 9;399(10344):2413-2426. Epub 2022 Jun 9.

Department of Specialized Clinical Sciences and Odontostomatology, Polytechnic University of Marche, Ancona, Italy.

Coeliac disease is an autoimmune disorder that primarily affects the small intestine, and is caused by the ingestion of gluten in genetically susceptible individuals. Prevalence in the general population ranges from 0·5% to 2%, with an average of about 1%. The development of the coeliac enteropathy depends on a complex immune response to gluten proteins, including both adaptive and innate mechanisms. Read More

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Pharmacological Management of Obesity: A Century of Expert Opinions in Cecil Textbook of Medicine.

Am J Ther 2022 Jun 10. Epub 2022 Jun 10.

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures/Internal Medicine I, Diabetes, Nutrition and Metabolic Diseases Outpatient Unit, Emergency County Clinical Hospital, Târgu Mureş, Romania.

Background: Innovations in drug therapy for obesity have had a limited impact on the body mass index, prevalence of medical complications, quality of life, and work potential of a substantial majority of affected persons.

Study Question: What are the milestones of the changes in the expert approach to the pharmacological management of obesity in the past century?

Study Design: To determine the changes in the experts' approach to the management of obesity, as presented in a widely used textbook in the United States.

Data Sources: The primary sources were chapters describing the management of obesity in the 26 editions of Cecil Textbook of Medicine published from 1927 through 2020. Read More

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Pathophysiology and Clinical Management of Bile Acid Diarrhea.

J Clin Med 2022 May 30;11(11). Epub 2022 May 30.

Division of Internal Medicine, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, Italy.

Bile acid malabsorption (BAM) represents a common cause of chronic diarrhea whose prevalence is under-investigated. We reviewed the evidence available regarding the pathophysiology and clinical management of bile acid diarrhea (BAD). BAD results from dysregulation of the enterohepatic recirculation of bile acids. Read More

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Enhanced Extracellular Transfer of HLA-DQ Activates CD3 Lymphocytes towards Compromised Treg Induction in Celiac Disease.

Int J Mol Sci 2022 May 29;23(11). Epub 2022 May 29.

Department of Medical Genetics, Third Faculty of Medicine, Charles University, Ruská 87, 10000 Prague, Czech Republic.

Celiac disease (CeD) manifests with autoimmune intestinal inflammation from gluten and genetic predisposition linked to human leukocyte antigen class-II (HLA-II) gene variants. Antigen-presenting cells facilitate gluten exposition through the interaction of their surface major histocompatibility complex (MHC) with the T cell receptor (TCR) on T lymphocytes. This fundamental mechanism of adaptive immunity has broadened upon recognition of extracellular exosomal MHC, raising awareness of an alternative means for antigen presentation. Read More

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