44,083 results match your criteria Malabsorption


A minimum of two years of undertreated primary hypothyroidism, as a result of drug-induced malabsorption of l-thyroxine, may have metabolic and cardiovascular consequences.

J Clin Transl Endocrinol 2019 Jun 10;16:100189. Epub 2019 Apr 10.

Medico di Medicina Generale, ASP 5, Messina, Italy.

Objective: Cross-sectional studies have reported that TSH above or close to the upper normal limit correlates with unfavorable metabolic and cardiovascular outcomes. Certain medications impair intestinal absorption of levothyroxine (L-T4), resulting in undertreated hypothyroidism (. failure of serum TSH to reach target levels, if hypothyroidism is primary). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22146237193002
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http://dx.doi.org/10.1016/j.jcte.2019.100189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462542PMC
June 2019
2 Reads

Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study.

Nutrients 2019 Apr 19;11(4). Epub 2019 Apr 19.

Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, via Amendola 165/a, 70126 Bari, Italy.

Functional gastrointestinal symptoms are frequent, and may be driven by several pathogenic mechanisms. Symptoms may persist in lactose intolerant (LI) patients (i.e. Read More

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http://dx.doi.org/10.3390/nu11040886DOI Listing

Chinese guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency (2018 Edition).

J Dig Dis 2019 Apr 21. Epub 2019 Apr 21.

Department of Gastroenterology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, China.

Pancreatic exocrine insufficiency (PEI) is a condition characterized by insufficient or unsynchronized secretion of pancreatic enzymes that results in maldigestion or malabsorption. The Chinese Study Group for Chronic Pancreatitis of the Chinese Medical Doctor Association gathered a group of experts on Gastroenterology, Biliary and Pancreatic Surgery, Radiology, Endocrinology, and Pathology to revise the Chinese Guidelines for the Diagnosis and Treatment of Pancreatic Exocrine Insufficiency (2012 Edition) based on the latest medical evidence both domestic and abroad. Read More

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http://dx.doi.org/10.1111/1751-2980.12753DOI Listing

Effect of bile acid supplementation on endogenous lipid synthesis in patients with short bowel syndrome: A pilot study.

Clin Nutr 2019 Apr 2. Epub 2019 Apr 2.

Nutrition Intensive Care Unit, Hospices Civil de Lyon, F-69495, Pierre Benite Cedex, France. Electronic address:

Background & Aims: Short bowel syndrome patients (SBS) receiving parenteral nutrition (PN) often have dyslipidaemia and can develop intestinal failure-associated liver disease (IFALD). These patients demonstrate increased cholesterol synthesis and hepatic lipogenesis. These lipid disturbances may be due to a decreased concentration of the bile acid pool or malabsorption. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193015
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http://dx.doi.org/10.1016/j.clnu.2019.03.037DOI Listing
April 2019
1 Read

Jejunal interposition for short bowel syndrome in a septuagenarian.

J Surg Case Rep 2019 Apr 10;2019(4):rjz095. Epub 2019 Apr 10.

Department of Surgery, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Short bowel syndrome in adults occurs as a result of massive small intestinal resection commonly due to severe Crohn's disease, volvulus or tumors. Diarrhea and weight loss are hallmarks of malabsorption which are aggravated if the colon is removed along with the small intestinal resection. Enteral nutrition autonomy is difficult to achieve in such cases of malabsorption where parenteral nutrition are required more often than not. Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjz09
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http://dx.doi.org/10.1093/jscr/rjz095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457064PMC
April 2019
1 Read

Brown bowel syndrome: a rare malnutrition-related complication of bariatric surgery.

Nutr Hosp 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery. Faculty of Medical Sciences. Universidade Estadual de Campinas (UNICAMP).

Case Report: we present the case of a 44-year-old male who presented with uncontrollable diarrhea, severe protein-calorie malnutrition and multiple vitamin deficiencies, along with peripheral neuropathy ten years after classic biliopancreatic diversion (BPD). He underwent nutritional support and had the surgery converted to a Roux-en-Y gastric bypass, with an uneventful outcome. The histopathology of the resected bowel revealed lipofuscinosis of the muscular layer compatible with brown bowel syndrome. Read More

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http://dx.doi.org/10.20960/nh.2257DOI Listing
April 2019
1 Read

The Importance of the Microbiome in Bariatric Surgery: a Systematic Review.

Obes Surg 2019 Apr 13. Epub 2019 Apr 13.

Department of Surgery, Catharina Hospital, Michelangelolaan 2, 5623 RJ, Eindhoven, The Netherlands.

Bariatric surgery results in sustained weight loss, improvement of metabolic and hormonal changes, and reduction of comorbidities in obese patients. However, beneficial effects of bariatric surgery are not solely explained by restriction and malabsorption induced by surgery itself. Changes in the microbiome might play a role in this mechanism. Read More

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http://dx.doi.org/10.1007/s11695-019-03863-yDOI Listing

Cystic fibrosis dyslipidaemia: A cross-sectional study.

J Cyst Fibros 2019 Apr 9. Epub 2019 Apr 9.

Poznan University of Medical Sciences, Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland. Electronic address:

Background: The interest in cystic fibrosis (CF) dyslipidaemia as a potential risk factor for cardiovascular disease is increasing with patients' survival. This study aimed to investigate CF dyslipidaemia, its clinical correlates and links to oxidized low-density lipoprotein (oxLDL), adiponectin, and apolipoprotein E (APOE).

Methods: This cross-sectional study assessed clinical characteristics of CF, as well as the serum lipid profile, oxLDL, adiponectin, and APOE. Read More

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http://dx.doi.org/10.1016/j.jcf.2019.04.001DOI Listing
April 2019
1 Read

Bilateral subtrochanteric femur insufficiency fractures after bariatric surgery: a case report.

Osteoporos Int 2019 Apr 11. Epub 2019 Apr 11.

Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, 3737 Market Street, 6th Floor, Philadelphia, PA, 19104, USA.

There have been case reports of proximal femur insufficiency fractures in patients who have previously undergone bariatric surgery. We present a follow-up case of a patient who developed bilateral complete proximal femur insufficiency fractures several years after bariatric surgery. Our patient underwent bilateral intramedullary fixation with a satisfactory postoperative outcome. Read More

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http://dx.doi.org/10.1007/s00198-019-04956-1DOI Listing

Investigating the association of proton pump inhibitors with chronic kidney disease and its impact on clinical practice and future research: a review.

Authors:
Ejaz Cheema

J Pharm Policy Pract 2019 29;12. Epub 2019 Mar 29.

Institute of clinical sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT UK.

Background: Proton pump inhibitors (PPIs) are used worldwide for the treatment of gastroesophageal reflux disease (GERD) and peptic ulcer disease (PUD). Although considered to be widely safe, PPIs have been associated with the potential risk of adverse effects such as infections including pneumonia and , malabsorption of vitamins and minerals, dementia and more recently with chronic kidney disease (CKD). Evidence including large cohort studies suggests that there is a greater risk of developing CKD in chronic users of PPIs. Read More

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http://dx.doi.org/10.1186/s40545-019-0167-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440100PMC
March 2019
4 Reads

Remission of bile acid malabsorption symptoms following treatment with the glucagon-like peptide 1 receptor agonist liraglutide.

Gastroenterology 2019 Apr 6. Epub 2019 Apr 6.

Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.04.002DOI Listing

EMPATHY: A new tool for identifying the most suitable thyroxine formulation in hypothyroid patients.

Thyroid 2019 Apr 9. Epub 2019 Apr 9.

napoli, Italy ;

Therapy of hypothyroidism is based on the administration of appropriate doses of L-thyroxine (L-T4). A failure to achieve the TSH target may be due to poor compliance with the L-T4 therapy in about 60% of cases or to malabsorption in about 40% of cases. No tools are available for detecting malabsorption disorders before the choice of the most appropriate therapy. Read More

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http://dx.doi.org/10.1089/thy.2018.0493DOI Listing
April 2019
1 Read

Identification of conserved candidate vaccine antigens in the surface proteome of .

Infect Immun 2019 Apr 8. Epub 2019 Apr 8.

Department of Medicine, University of California, San Diego, La Jolla, California, USA

, one of the most common protozoal infections of the human intestine, is an important worldwide cause of diarrheal disease, malabsorption, malnutrition, delayed cognitive function in children, and protracted post-infectious syndromes. Despite its medical importance, no human vaccine is available against giardiasis. A crude veterinary vaccine has been developed, and experimental vaccines based on expression of multiple variant-specific surface proteins have been reported, but poorly defined vaccine components and excessive antigen variability are problematic for pharmaceutical vaccine production. Read More

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http://dx.doi.org/10.1128/IAI.00219-19DOI Listing
April 2019
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Antimicrobial peptide KR-32 alleviates Escherichia coli K88-induced fatty acid malabsorption by improving expression of FATP4.

J Anim Sci 2019 Apr 8. Epub 2019 Apr 8.

National Engineering Laboratory of Biological Feed Safety and Pollution Prevention and Control, Key Laboratory of Animal Nutrition and Feed, Ministry of Agriculture, Key Laboratory of Animal Nutrition and Feed Science of Zhejiang Province, Zhejiang University, Yuhang Tang Road, Hangzhou Zhejiang, P.R. China.

Bacterial infection causes nutrient malabsorption in small intestine. KR-32, a kind of synthetic antimicrobial peptide, has the bacteriostatic effect. In the present study, 2 experiments were designed to analyze the effects of KR-32 on fat absorption of piglets with or without E. Read More

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http://dx.doi.org/10.1093/jas/skz110DOI Listing
April 2019
1 Read

Neuro-hormonal mechanisms underlying changes in reward related behaviors following weight loss surgery: Potential pharmacological targets.

Biochem Pharmacol 2019 Apr 4;164:106-114. Epub 2019 Apr 4.

Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, United States.

Currently, the only available effective treatment option for obesity and its comorbidities is weight loss surgery (WLS). Long-term maintenance of weight loss after surgery cannot be explained by caloric restriction or malabsorption alone and has been attributed to unexplained changes in eating behavior. Whether these behavioral changes are related to altered taste or reward functions, or both, are subject to debate. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.04.004DOI Listing
April 2019
2 Reads

An unusual cause of chronic diarrhea: plastron appendicitis.

Gastroenterol Hepatol Bed Bench 2019 ;12(1):74-75

Ankara Numune Training and Research Hospital, Department of Internal Medicine, Ankara, Turkey.

Chronic diarrhea is defined as diarrhea that lasts longer than four weeks. Etiology of chronic diarrhea includes inflammatory bowel disease, malabsorption syndromes, irritable bowel disease, chronic parasitic infections, bacterial toxins, drugs and motility disorders. Plastron appendicitis is an abscess formation that occurs when the appendix is surrounded by the omentum following perforation of acute appendicitis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441483PMC
January 2019
1 Read

Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity.

PLoS One 2019 4;14(4):e0214621. Epub 2019 Apr 4.

Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.

Experimental non-human primate models of obesity are induced through the introduction of atypically calorically rich diets. Studies in captive-bred macaques show the development of obesity and diabetes with similar complications to humans including eye and kidney diseases, nerve damage associated with pain and blood vessel damage. Diets differ in outcomes and here we document inflammation of the gastrointestinal tract that can be exacerbated through these dietary interventions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214621PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448857PMC
April 2019
5 Reads

Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism.

FASEB J 2019 Apr 2:fj201801526RR. Epub 2019 Apr 2.

Micalis Institute, Institut National de la Recherche Agronomique (INRA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

Current fructose consumption levels often overwhelm the intestinal capacity to absorb fructose. We investigated the impact of fructose malabsorption on intestinal endocrine function and addressed the role of the microbiota in this process. To answer this question, a mouse model of moderate fructose malabsorption [ketohexokinase mutant (KHK)] and wild-type (WT) littermate mice were used and received a 20%-fructose (KHK-F and WT-F) or 20%-glucose diet. Read More

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https://www.fasebj.org/doi/10.1096/fj.201801526RR
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http://dx.doi.org/10.1096/fj.201801526RRDOI Listing
April 2019
5 Reads

Identification of human D lactate dehydrogenase deficiency.

Nat Commun 2019 04 1;10(1):1477. Epub 2019 Apr 1.

Department of Genetics, University Medical Center Utrecht, Utrecht, 3584, CX, The Netherlands.

Phenotypic and biochemical categorization of humans with detrimental variants can provide valuable information on gene function. We illustrate this with the identification of two different homozygous variants resulting in enzymatic loss-of-function in LDHD, encoding lactate dehydrogenase D, in two unrelated patients with elevated D-lactate urinary excretion and plasma concentrations. We establish the role of LDHD by demonstrating that LDHD loss-of-function in zebrafish results in increased concentrations of D-lactate. Read More

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http://dx.doi.org/10.1038/s41467-019-09458-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443703PMC
April 2019
2 Reads

Small bowel adenocarcinoma as a complication of celiac disease: clinical and diagnostic features.

BMC Gastroenterol 2019 Mar 27;19(1):45. Epub 2019 Mar 27.

Department of Medical Sciences, University of Ferrara, St. Anna Hospital, Via Aldo Moro, 8, 44124, Ferrara, Cona, Italy.

Background: Small bowel adenocarcinoma (SBA) is a rare neoplasm, which can occur in a sporadic form or can be associated with a number of predisposing conditions such as hereditary syndromes and immune-mediated intestinal disorders, e.g. celiac disease (CD). Read More

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http://dx.doi.org/10.1186/s12876-019-0964-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437995PMC
March 2019
1 Read

Serum PTH reference values in an adult Brazilian population: implications for the diagnosis of hyperparathyroidism.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brasil.

Objective: To define serum parathyroid hormone (PTH) reference values in carefully selected subjects following the recommended pre-analytical guidelines.

Subjects And Methods: First, 676 adults who would be submitted to thyroidectomy were evaluated. Patients using interfering medications or with malabsorption syndrome, hypomagnesemia, hyper- or hypophosphatemia, hypo- or hypercalcemia, 25-hydroxyvitamin D < 30 ng/dL, estimated glomerular filtration rate < 60 mL/min/1. Read More

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http://dx.doi.org/10.20945/2359-3997000000117DOI Listing
March 2019
1 Read

Metabolomics-based identification of metabolic alterations in PARK2.

Ann Clin Transl Neurol 2019 Mar 21;6(3):525-536. Epub 2019 Feb 21.

Department of Neurology Juntendo University School of Medicine Tokyo Japan.

Objective: is the causative gene for autosomal recessive familial Parkinson's disease (PD), although it remains unclear how parkin dysfunction is involved with the general condition. Recently, serum and/or plasma metabolomics revealed alterations in metabolic pathways that might reflect pathomechanisms of idiopathic PD (iPD). Thus, we hypothesized that serum metabolomics of patients with homozygous or compound heterozygous mutations (namely, PARK2) might reflect metabolic alterations due to parkin dysfunction. Read More

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http://dx.doi.org/10.1002/acn3.724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414487PMC
March 2019
1 Read

In vitro formation of Maillard reaction products during simulated digestion of meal-resembling systems.

Food Res Int 2019 Apr 21;118:72-80. Epub 2017 Sep 21.

Food Bioscience Group, Department of Bioactivity and Food Analysis, Institute of Food Science Research (CIAL, UAM-CSIC), C/ Nicolás Cabrera, 9, Campus de Cantoblanco, Universidad Autónoma de Madrid, 28049 Madrid, Spain. Electronic address:

The aim of the present research was to study the formation of Maillard reaction products (MRPs) during digestive process of meal-resembling systems. An average meal (protein, starch and oil) and sugar-containing meals (protein and glucose or fructose or high fructose corn syrup (HCFS)) were tested. Intestinal simple amino acid systems were also analyzed to gain insight into their contribution to the Maillard reaction (MR). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09639969173064
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http://dx.doi.org/10.1016/j.foodres.2017.09.056DOI Listing
April 2019
3 Reads

Switch from tablet levothyroxine to oral solution resolved reduced absorption by intestinal parasitosis.

Endocrinol Diabetes Metab Case Rep 2019 Mar 21;2019. Epub 2019 Mar 21.

Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Salerno, Italy.

Reduced intestinal absorption of levothyroxine (LT4) is the most common cause of failure to achieve an adequate therapeutic target in hypothyroid patients under replacement therapy. We present the case of a 63-year-old woman with autoimmune hypothyroidism previously well-replaced with tablet LT4 who became unexpectedly no more euthyroid. At presentation, the patient reported the onset of acute gastrointestinal symptoms characterized by nausea, loss of appetite, flatulence, abdominal cramps and diarrhea, associated with increase of thyrotropin levels (TSH: 11 mIU/mL). Read More

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http://dx.doi.org/10.1530/EDM-19-0026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432983PMC
March 2019
3 Reads

Chronic ethanol consumption alters lamina propria leukocyte response to stimulation in a region-dependent manner.

FASEB J 2019 Mar 21:fj201802780R. Epub 2019 Mar 21.

Department of Molecular Biology and Biochemistry, University of California-Irvine, Irvine, California, USA.

Chronic heavy alcohol consumption, also referred to as chronic heavy drinking (CHD), results in intestinal injury characterized by increased permeability, dysbiosis, nutrient malabsorption, potentially higher susceptibility to infection, and increased risk of colorectal cancer. However, our understanding of the mechanisms by which CHD results in intestinal damage remains incomplete. Here, we investigated the impact of chronic drinking on transcriptional and functional responses of lamina propria leukocytes (LPLs) isolated from the 4 major gut sections. Read More

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http://dx.doi.org/10.1096/fj.201802780RDOI Listing
March 2019
2 Reads

Experience of Using a Semielemental Formula for Home Enteral Nutrition in Children: A Multicenter Cross-sectional Study.

J Pediatr Gastroenterol Nutr 2019 Apr;68(4):585-590

Department of Pediatric Gastroenterology, Hepatology and Nutrition, CHU Lille, University Lille, Lille, France.

Objectives: The use of semielemental diets concerns a small proportion of children on enteral nutrition whose characteristics have never been reported. Our aim was to describe a cohort of patients on home enteral nutrition with Peptamen Junior, including the tolerance and nutritional efficacy of this product.

Methods: We performed a retrospective multicenter survey on a cohort of patients receiving this semielemental diet at home between 2010 and 2015 in 14 tertiary pediatric French centers. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002236DOI Listing
April 2019
1 Read

The impact of exercise-induced hypohydration on gastrointestinal integrity, function, symptoms, and systemic endotoxin and inflammatory profile.

J Appl Physiol (1985) 2019 Mar 21. Epub 2019 Mar 21.

Department of Nutrition, Dietetics and Food, Monash University, Australia.

It is commonly believed that gastrointestinal issues during exercise are exacerbated by hypohydration. The study aimed to determine the effect of exercise-induced hypohydration on gastrointestinal integrity, function, symptoms, systemic endotoxin, and inflammatory profile. Using a randomised cross-over design, male endurance runners (n=11) performed 2h of running at 70% V ̇O in 25°C ambient temperature, with water provisions (euhydration (EuH)) and total water restriction (hypohydration (HypoH)) during running, which accounted for 0. Read More

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http://dx.doi.org/10.1152/japplphysiol.01032.2018DOI Listing

Macroscopic hematuria as presenting symptom of celiac disease.

Neth J Med 2019 Feb;77(2):84-85

Department of Internal Medicine, Spaarne Gasthuis Hospital, Haarlem/Hoofddorp, the Netherlands.

A 47-year old man was admitted for macroscopic hematuria and spontaneous hematomas. Laboratory results showed a prolonged partial thromboplastin time (PTT), a prolonged activated partial thromboplastin time (APTT) and a severe vitamin K deficiency. The underlying cause proved to be vitamin K malabsorption due to previously undiagnosed celiac disease, possibly provoked by oral antibiotic administration. Read More

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February 2019
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A Novel Mutation of the Calcium-Sensing Receptor Gene Causing Familial Hypocalciuric Hypercalcemia Complicates Medical Followup after Roux-en-Y Gastric Bypass: A Case Report and a Summary of Mutations Found in the Same Hospital Laboratory.

Case Rep Endocrinol 2019 13;2019:9468252. Epub 2019 Feb 13.

Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Denmark.

Heterozygous inactivating mutations in the calcium-sensing receptor (CaSR) gene are known to cause familial hypocalciuric hypercalcemia (FHH), usually a benign form of hypercalcemia without symptoms of a disrupted calcium homeostasis. FHH can be mistaken for the more common primary hyperparathyroidism (PHPT), for which surgical treatment may be needed. We describe a case of a 36-year-old woman with hypercalcemia and elevated PTH, initially suspected of having PHPT. Read More

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http://dx.doi.org/10.1155/2019/9468252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393866PMC
February 2019
1 Read

Lactose intolerance: what is a correct management?

Rev Assoc Med Bras (1992) 2019 Feb;65(2):270-275

Life Sciences Department, State University of Bahia, Rua Silveira Martins, 2555, Cabula. 41150-000, Salvador, Bahia, Brasil.

Individuals with Lactose Intolerance (LI) tend to exclude milk from their diet since this behavior seems to relieve the symptoms caused by the disease. However, milk is a food of high nutritional value, and complete exclusion of dairy products may favor the development of bone diseases such as osteopenia and osteoporosis. The objective of this review was to evaluate the scientific evidence on the adequate management of patients with LI. Read More

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http://dx.doi.org/10.1590/1806-9282.65.2.270DOI Listing
February 2019
1 Read

Coeliac disease in Caucasian and South Asian patients in the North West of England.

J Hum Nutr Diet 2019 Mar 20. Epub 2019 Mar 20.

Gastroenterology Department, Royal Blackburn Hospital, Blackburn, UK.

Background: Coeliac disease is an autoimmune enteropathy characterised by mucosal inflammation subsequent to gluten exposure, leading to malabsorption. Treatment is strict dietary control, relying on the patient's ability to maintain lifestyle modifications. The present study aimed to compare clinical presentation and adherence to a gluten-free diet between South Asian and Caucasian patients with coeliac disease in East Lancashire METHODS: In total, 33 South Asian and 113 Caucasian adult patients diagnosed with coeliac disease under the care of the Dietetics Department at East Lancashire Hospitals NHS Trust were selected using a convenience sampling method and then allocated to the South Asian or Caucasian group. Read More

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http://dx.doi.org/10.1111/jhn.12622DOI Listing
March 2019
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Extra-Intestinal Manifestations of Coeliac Disease in Children: Clinical Features and Mechanisms.

Front Pediatr 2019 5;7:56. Epub 2019 Mar 5.

Department of Medical Translational Sciences and European Laboratory for the Investigation of Food-Induced Diseases, University of Naples Federico II, Naples, Italy.

Celiac disease (CD) is a systemic autoimmune disease due to a dysregulated mucosal immune response to gluten and related prolamines in genetically predisposed individuals. It is a common disorder affecting ~1% of the general population, its incidence is steadily increasing. Changes in the clinical presentation have become evident since the 80s with the recognition of extra-intestinal symptoms like short stature, iron deficiency anemia, altered bone metabolism, elevation of liver enzymes, neurological problems. Read More

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http://dx.doi.org/10.3389/fped.2019.00056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413622PMC
March 2019
4 Reads

Isolated Amylase Deficiency in Children and its Clinical Implication.

J Pediatr Gastroenterol Nutr 2019 Feb 20. Epub 2019 Feb 20.

Clinical Professor of Pediatrics, The Florida State University, Center for Digestive Health and Nutrition, Arnold Palmer Hospital for Children, Orlando, FL.

Objectives And Study: Among the three lines of pancreatic enzymes, amylase secretion develops last and it is not detected in duodenal aspirates of infants in the first month after birth. The aim of this study was to assess the prevalence and symptoms of isolated amylase deficiency in children.

Methods: During a 6-year period we performed endoscopic pancreatic function tests (ePFT) in 712 children. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002317DOI Listing
February 2019
1 Read

Chronic diarrhoea in adults: what not to miss.

Curr Opin Gastroenterol 2019 May;35(3):206-212

NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust.

Purpose Of Review: Chronic diarrhoea remains a diagnostic challenge, with numerous causes and few effective symptomatic treatments. This review focuses on new methods for diagnosis of common disorders and alerts readers to rarer causes through a systematic approach to the underlying mechanisms.

Recent Findings: New strategies are emerging to stratify the need for endoscopic investigation. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000516DOI Listing
May 2019
2 Reads

[Tetany as a form of presentation of adult celiac disease.]

Rev Fac Cien Med Univ Nac Cordoba 2019 02 27;76(1):56-58. Epub 2019 Feb 27.

Dpto. de Medicina Interna. Hospital Nacional. Itauguá, Paraguay.

Introduction: celiac disease is an autoimmune disease with symptoms involving multiple organs. The forms of presentation vary considerably, which makes it difficult to diagnose. The objective is to present an atypical case of celiac disease. Read More

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http://dx.doi.org/10.31053/1853.0605.v76.n1.20212DOI Listing
February 2019
4 Reads

3D-real IR MRI detects serendipity of inner ear in enlarged vestibular aqueduct syndrome.

Acta Otolaryngol 2019 Mar 18:1-5. Epub 2019 Mar 18.

a NHC Key Laboratory of Hearing Medicine , Fudan University , Shanghai , PR China.

Background: Although, the diagnostic criteria for enlarged vestibular aqueduct syndrome (EVAS) were determined by years. On the shoulders of predecessors, we still detected some new discoveries about EVAS by using 3D-real IR MRI.

Aims/objectives: To analyze the signal intensity of membranous and osseous labyrinths of vestibular aqueduct (VA) and endolymphatic sac (ES) in EVAS using three-dimensional real inversion recovery (3D-Real-IR) magnetic resonance imaging (MRI) after intratympanic injection of gadolinium. Read More

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http://dx.doi.org/10.1080/00016489.2018.1563719DOI Listing
March 2019
1 Read

Growth failure in pediatric onset inflammatory bowel disease: mechanisms, epidemiology, and management.

Authors:
Takashi Ishige

Transl Pediatr 2019 Jan;8(1):16-22

Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Impairment of growth is recognized as one of the most significant complications of inflammatory bowel disease (IBD) in pediatric patients. The reported incidence of growth failure at diagnosis is 15-40% in pediatric onset Crohn's disease (CD) and 3-10% in ulcerative colitis (UC). Growth failure is associated with decreased appetite, abdominal symptoms, malabsorption due to mucosal inflammation, growth hormone (GH) resistance due to inflammation, and even genetic factors. Read More

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http://dx.doi.org/10.21037/tp.2018.12.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382509PMC
January 2019
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Vitamin D and vitamin B deficiencies in patients with small intestinal carcinoid tumour: is opioid use disorder a confounding factor in the diagnosis?

BMJ Case Rep 2019 Mar 16;12(3). Epub 2019 Mar 16.

Allama Iqbal Medical College, Lahore, Pakistan.

Carcinoid tumours have the ability to secrete various peptides and bioamines that lead to carcinoid syndrome manifested as cutaneous flushing, diarrhoea, bronchial constriction and cardiac involvement. The deficiencies of vitamins D and B have previously been reported in patients with carcinoid tumours presumably due to chronic diarrhoea associated with the carcinoid syndrome. Herein, we chronicle the case of a patient with opioid use disorder who presented with small bowel obstruction that was found to be caused by a midgut carcinoid tumour. Read More

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http://dx.doi.org/10.1136/bcr-2018-227430DOI Listing
March 2019
2 Reads

Zinc and skin: an update.

J Dtsch Dermatol Ges 2019 Mar 15. Epub 2019 Mar 15.

Department of Dermatology, Venereology and Allergology, University Medical Center, Würzburg, Germany.

The essential trace element zinc (Zn) plays a key role in the development, differentiation and growth of various human tissues. Zinc homeostasis is primarily regulated by two zinc transporter families (solute-linked carrier families, SLC). Disturbances in zinc metabolism may give rise to disorders that typically manifest themselves on the skin. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13811
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http://dx.doi.org/10.1111/ddg.13811DOI Listing
March 2019
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Serum Hepcidin Levels Predict Intestinal Iron Absorption in Patients with Inflammatory Bowel Disease.

Clin Lab 2019 Mar;65(3)

Background: Hepcidin has been shown to be inversely associated with iron absorption and the expression of iron transport proteins in healthy females and patients with iron deficiency. Data describing the relationship between hepcidin expression and iron absorption in patients with inflammatory bowel disease (IBD) are lacking. The objective of this study was to assess the relationship between serum concentrations of hepcidin and iron absorption in patients with IBD and iron deficiency by means of an oral iron absorption test. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.190106DOI Listing
March 2019
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Levothyroxine absorption test results in patients with TSH elevation resistant to treatment.

Endocrine 2019 Apr 13;64(1):118-121. Epub 2019 Mar 13.

Division of Endocrinology and Metabolism Disorders, Ege University Medical Faculty, Izmir, Turkey.

Introduction: Persistent elevation of thyroid-stimulating hormone (TSH) is common in endocrinology practice in patients undergoing replacement or suppression therapy with levothyroxine sodium (LT4). After examining the causes of this condition, LT4 absorption test is recommended. In this report, we wanted to share our results of LT4 absorption test in patients with elevated TSH levels. Read More

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http://dx.doi.org/10.1007/s12020-019-01889-xDOI Listing
April 2019
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Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.

Nat Commun 2019 03 13;10(1):1198. Epub 2019 Mar 13.

Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, L8S 4K1, ON, Canada.

Microbe-host interactions are generally homeostatic, but when dysfunctional, they can incite food sensitivities and chronic diseases. Celiac disease (CeD) is a food sensitivity characterized by a breakdown of oral tolerance to gluten proteins in genetically predisposed individuals, although the underlying mechanisms are incompletely understood. Here we show that duodenal biopsies from patients with active CeD have increased proteolytic activity against gluten substrates that correlates with increased Proteobacteria abundance, including Pseudomonas. Read More

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http://dx.doi.org/10.1038/s41467-019-09037-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416356PMC
March 2019
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Why do lung transplant patients discontinue triazole prophylaxis?

Transpl Infect Dis 2019 Mar 13:e13067. Epub 2019 Mar 13.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota.

Background: Lung transplant recipients are prone to invasive fungal infections prompting many transplant centers to use prolonged triazole antifungal prophylaxis. From a practical standpoint, it is unclear if lung transplant recipients are able to continue prolonged or lifelong prophylaxis without premature discontinuation from side effects, drug interactions, development of fungal disease, or medication cost. We examined the number of patients that are able to reach a prophylactic endpoint and understand the reasons for early termination. Read More

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http://dx.doi.org/10.1111/tid.13067DOI Listing
March 2019
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Excess weight and gastrointestinal symptoms in Chilean celiac patients at the time of diagnosis.

Rev Esp Enferm Dig 2019 Mar 12. Epub 2019 Mar 12.

Pontificia Universidad Católica de Chile.

Introduction: celiac disease is an immune condition that results in histologic changes in the small bowel and produces both digestive and extra-digestive symptoms. Intestinal damage results in malabsorption and impaired weight or impaired optimal weight gain. However, these patients may be overweight or obese in spite of histologic damage. Read More

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http://dx.doi.org/10.17235/reed.2019.5251/2017DOI Listing

Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation.

J Biol Chem 2019 Mar 11. Epub 2019 Mar 11.

College of Medicine, Albert Einstein Cancer Center, United States.

The proton-coupled folate transporter (PCFT) mediates intestinal absorption of folates and their transport from blood to cerebrospinal fluid across the choroid plexus. Substitutions at Asp109 in the first intracellular loop between the first and second transmembrane domains (TMDs) abolish PCFT function, but protein expression and trafficking to the cell membrane are retained. Here, we used site-directed mutagenesis, the substituted-cysteine accessibility method, functional analyses and homology modeling, to determine whether the D109A substitution locks PCFT in one of its conformational states. Read More

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http://dx.doi.org/10.1074/jbc.RA118.005533DOI Listing

Significant Weight Loss In A Patient Taking Olmesartan: An Unusual Case Report.

Curr Drug Saf 2019 Mar 7. Epub 2019 Mar 7.

Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina. Greece.

Objective: Olmesartan-induced enteropathy consists a syndrome that mimics celiac disease both clinically and histologically. Cases of this entity have sporadically been reported since 2012 and are usually characterized by severe diarrhea and malabsorption, followed by significant weight loss.

Case Report: Herein, we report an uncommon case of this syndrome, where weight loss preceded several months the onset of gastrointestinal symptoms. Read More

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http://dx.doi.org/10.2174/1574886314666190307142111DOI Listing
March 2019
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The role of small bowel endoscopy for Crohn's disease.

Curr Opin Gastroenterol 2019 May;35(3):223-234

Academic Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, UK.

Purpose Of Review: The review discusses the roles of small bowel capsule endoscopy and deep enteroscopy in patients with Crohn's disease. It highlights recent advances in the field and identifies areas where evidence is lacking.

Recent Findings: Small bowel capsule endoscopy has an important role in the follow-up of patients with Crohn's disease after escalation of therapy and in the postoperative assessment period following surgical resection. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000519DOI Listing
May 2019
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The relationship between plasma homocysteine levels and MTHFR gene variation, age, and sex in Northeast China.

Niger J Clin Pract 2019 Mar;22(3):380-385

Chinese Ministry of Health Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.

Background: Hyperhomocysteinemia (HHcy) is the risk factor for cardiovascular disease and stroke. However, the impacts on the genetic variation of methylene tetrahydrofolate reductase (MTHFR) on plasma homocysteine levels in the Northeast Chinese population have not been studied. Therefore, this study was carried out to determine the relationship between HHcy and MTHFR gene variation, and whether it was influenced by age and sex of the population in Northeast China. Read More

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http://dx.doi.org/10.4103/njcp.njcp_291_18DOI Listing

Evaluation of symptoms and symptom combinations in histamine intolerance.

Intest Res 2019 Mar 7. Epub 2019 Mar 7.

Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria.

Background/aims: Food intolerance/malabsorption, particularly histamine intolerance (HIT), may cause nonspecific functional gastrointestinal and extraintestinal symptoms. We evaluated gastrointestinal and extraintestinal symptoms in patients with HIT.

Methods: In an analysis of outpatients' charts we identified 133 patients, who presented with recurring nonspecific functional gastrointestinal, extraintestinal symptoms, and a diamine oxidase value <10 U/mL, indicative of HIT. Read More

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http://dx.doi.org/10.5217/ir.2018.00152DOI Listing
March 2019
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