43,595 results match your criteria Malabsorption


Celiac Disease: A Review of Current Concepts in Pathogenesis, Prevention, and Novel Therapies.

Front Pediatr 2018 21;6:350. Epub 2018 Nov 21.

The Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.

Our understanding of celiac disease and how it develops has evolved significantly over the last half century. Although traditionally viewed as a pediatric illness characterized by malabsorption, it is now better seen as an immune illness with systemic manifestations affecting all ages. Population studies reveal this global disease is common and, in many countries, increasing in prevalence. Read More

View Article
November 2018
6 Reads

Metabolic Signatures of Cystic Fibrosis Identified in Dried Blood Spots For Newborn Screening Without Carrier Identification.

J Proteome Res 2018 Dec 3. Epub 2018 Dec 3.

Cystic fibrosis (CF) is a complex multi-organ disorder that is among the most common fatal genetic diseases benefiting from therapeutic interventions early in life. Newborn screening (NBS) for pre-symptomatic detection of CF currently relies on a two-stage immunoreactive trypsinogen (IRT) and cystic fibrosis transmembrane conductance regulator (CFTR) mutation panel algorithm that is sensitive, but not specific for identifying affected neonates with a low positive predictive value. For the first time, we report the discovery of a panel of CF-specific metabolites from a single 3. Read More

View Article
December 2018

Severe gastrointestinal disease in very early systemic sclerosis is associated with early mortality.

Rheumatology (Oxford) 2018 Dec 4. Epub 2018 Dec 4.

Department of Medicine, McGill University.

Objectives: To examine the incidence, predictors and outcomes associated with severe gastrointestinal (GI) disease in a large inception SSc cohort.

Methods: SSc subjects with <2 years of disease duration were identified from two multicentre cohorts. Severe GI disease was defined as: malabsorption, hyperalimentation, pseudo-obstruction and/or ⩾10% weight loss in association with the use of antibiotics for bacterial overgrowth or oesophageal stricture. Read More

View Article
December 2018
2 Reads

Intravenous zanamivir for influenza myocarditis and enteral malabsorption.

Crit Care 2018 Dec 4;22(1):332. Epub 2018 Dec 4.

Department of Intensive Care Medicine and Burns, Lausanne University Hospital Medical Center, CHUV, 1011, Lausanne, Switzerland.

View Article
December 2018

A cross-sectional study of national outpatient gastric acid suppressant prescribing in the United States between 2009 and 2015.

PLoS One 2018 30;13(11):e0208461. Epub 2018 Nov 30.

College of Pharmacy, The University of Texas at Austin, Austin, TX, United States of America.

Purpose: Gastric acid suppressants are commonly used in the United States, and while generally well-tolerated, long-term use has been associated with infection, bone fractures, and nutrient malabsorption. The purpose of this study was to describe national trends in gastric acid suppressant use over a 7-year period.

Methods: This was a cross-sectional study using data from the National Ambulatory Medical Care Survey from 2009 to 2015. Read More

View Article
November 2018

Changing Epidemiology of Liver Involvement in Children with Celiac Disease.

J Pediatr Gastroenterol Nutr 2018 Nov 27. Epub 2018 Nov 27.

Department of Medicine, Surgery, and Health Sciences, University of Trieste, Trieste, Italy.

Objectives: Available data indicate that liver involvement is present in a significant proportion of children with celiac disease (CD) at the diagnosis (elevated transaminases 15-57%, autoimmune liver disease 1-2%). We sought to evaluate prevalence, clinical course, and risk factors for liver involvement in a large cohort of children with CD.

Methods: Children (age 0-18 years) diagnosed with CD from March 2010 to April 2016 were enrolled. Read More

View Article
November 2018
2.625 Impact Factor

The Mini-Gastric Bypass original technique.

Int J Surg 2018 Nov 24;61:38-41. Epub 2018 Nov 24.

Department of Surgery, Kular Hospital Pvt. Ltd., National Highway 1, Bija, Khanna, Ludhiana, Punjab, 141412, India. Electronic address:

Introduction: Mini-Gastric Bypass (MGB) is becoming more and more popular as shown by the numerous articles published over the past 15 years, supporting the operation as a short and simple procedure with excellent outcomes and low complication rates. There is still confusion amongst surgeons on the technique of the operation. The purpose of this paper is to review and describe the technique of MGB by its originators. Read More

View Article
November 2018
1 Read

Gastrointestinal Malabsorption of Thyroxine.

Endocr Rev 2018 Nov 23. Epub 2018 Nov 23.

Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Latina, Italy.

Levothyroxine, a largely prescribed drug with a narrow therapeutic index, is often a lifelong treatment. The therapeutic efficacy of thyroxine may be marred by behavioral, pharmacologic and pathologic issues acting as interfering factors. Despite a continuous search for an optimal thyroxine treatment, a significant number of patients fail to show a complete chemical and/or clinical response to this reference dose of thyroxine. Read More

View Article
November 2018
7 Reads

Yogurt and other fermented foods as sources of health-promoting bacteria.

Nutr Rev 2018 Dec;76(Supplement_1):4-15

Department of Food Science and Technology, University of Nebraska, Lincoln, Nebraska, USA.

Increased consumption of yogurt, kefir, and other fermented foods has been driven, in part, by the health benefits these products may confer. Epidemiological studies have shown that the consumption of fermented foods is associated with reduced risks of type 2 diabetes, metabolic syndrome, and heart disease, along with improved weight management. The microorganisms present in these foods are suggested to contribute to these health benefits. Read More

View Article
December 2018
15 Reads

Secondary Oxalate Nephropathy: A Systematic Review.

Kidney Int Rep 2018 Nov 29;3(6):1363-1372. Epub 2018 Jul 29.

Division of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.

Introduction: Little is known of the clinical outcomes of secondary oxalate nephropathy. To inform clinical practice, we performed a systematic review of case reports and case series to examine the clinical characteristics and outcomes of patients with secondary oxalate nephropathy.

Methods: Electronic databases were searched for case reports and case series of individual cases or cohorts of patients with biopsy-proven oxalate nephropathy in native or transplanted kidneys from 1950 until January 2018. Read More

View Article
November 2018
4 Reads

Intestinal IgA tTG deposits in the duodenal bulb in patients with celiac disease: light at the beginning of the tunnel!

Gastrointest Endosc 2018 12;88(6):970-971

Department of Medicine, Government Medical College Hospital 32, Chandigarh, India.

View Article
December 2018
1 Read

Serum Concentrations of 7α-hydroxy-4-cholesten-3-one are Associated with Bile Acid Diarrhea in Patients with Crohn's Disease.

Clin Gastroenterol Hepatol 2018 Nov 15. Epub 2018 Nov 15.

Division of Gastroenterology, University of California San Diego, La Jolla, California, USA. Electronic address:

Background & Aims: Patients with Crohn's disease (CD) often have bile acid diarrhea (BAD), due to bile acid malabsorption following ileal resection (IR). Bile acid malabsorption increases production of 7α-hydroxy-4-cholesten-3-one (C4), a bile acid precursor. We investigated relationships between serum concentrations of C4 and BAD in patients with CD. Read More

View Article
November 2018
1 Read

Vitamin D intake, serum 25-hydroxy vitamin D and pulmonary function in paediatric patients with cystic fibrosis: a longitudinal approach.

Br J Nutr 2018 Nov 16:1-7. Epub 2018 Nov 16.

1Department of Paediatric Gastroenterology,University Medical Centre Utrecht,KE.04.133.1,P.O. Box 85500,3508 GA Utrecht,The Netherlands.

Pancreatic-insufficient children with cystic fibrosis (CF) receive age-group-specific vitamin D supplementation according to international CF nutritional guidelines. The potential advantageous immunomodulatory effect of serum 25-hydroxy vitamin D (25(OH)D) on pulmonary function (PF) is yet to be established and is complicated by CF-related vitamin D malabsorption. We aimed to assess whether current recommendations are optimal for preventing deficiencies and whether higher serum 25(OH)D levels have long-term beneficial effects on PF. Read More

View Article
November 2018
4 Reads

Development of Biomarkers for Inhibition of SLC6A19 (B⁰AT1)-A Potential Target to Treat Metabolic Disorders.

Int J Mol Sci 2018 Nov 14;19(11). Epub 2018 Nov 14.

Research School of Biology, Australian National University, Canberra, ACT 2601, Australia.

Recent studies have established that dietary protein restriction improves metabolic health and glucose homeostasis. SLC6A19 (B⁰AT1) is the major neutral amino acid transporter in the intestine and carries out the bulk of amino acid absorption from the diet. Mice lacking SLC6A19 show signs of protein restriction, have improved glucose tolerance, and are protected from diet-induced obesity. Read More

View Article
November 2018

Recognizing the leaky gut as a trans-diagnostic target for neuro-immune disorders using clinical chemistry and molecular immunology assays.

Curr Top Med Chem 2018 Nov 14. Epub 2018 Nov 14.

Department of Psychiatry and Medical Psychology, Medical Faculty, Medical University of Plovdiv, Plovdiv. Bulgaria.

Background: Increased intestinal permeability with heightened translocation of Gram-negative bacteria, also known as "leaky gut", is associated with the pathophysiology of neuroimmune disorders, such as major depressive disorder (MDD), chronic fatigue syndrome (CSF) and (deficit) schizophrenia, as well as with general medical disorders, including irritable bowel syndrome. This review aims to summarize clinical biochemistry and molecular immunology tests that may aid in the recognition of leaky gut in clinical practice.

Methods: We searched online libraries, including PubMed/MEDLINE, Google Scholar and Scopus, with the key words "diagnosis" or "biomarkers" and "leaky gut", "bacterial translocation", and "intestinal permeability" and focused on papers describing tests that may aid in the clinical recognition of leaky gut. Read More

View Article
November 2018
7 Reads

Robotic distal pancreatectomy with selective closure of pancreatic duct: surgical outcomes.

Updates Surg 2018 Nov 14. Epub 2018 Nov 14.

Division of Oncological and Robotic General Surgery, Careggi University Hospital, Florence, Italy.

Pancreatic fistula is the main post-operative complication of distal pancreatectomy associated with other further complications, such as intra-abdominal abscesses, wound infection, sepsis, electrolyte imbalance, malabsorption and hemorrhage. Surgeons have tried various techniques to close the stump of the remaining pancreas, but the controversy regarding the impact of stapler closure and suture closure of the pancreatic stump is far from resolved. In this study, we reported our technique and results of robotic assisted distal pancreatectomy with ultrasound identification and consequent selective closure of pancreatic duct. Read More

View Article
November 2018
6 Reads

High Prevalence of Pathological Hydrogen Breath Tests in Patients with Functional Dyspepsia.

Digestion 2018 Nov 14:1-6. Epub 2018 Nov 14.

Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Goettingen, Goettingen, Germany.

Background/aims: The aim of the study is to investigate the frequency of pathological hydrogen breath tests (HBT) in patients with clinical features of functional dyspepsia (FD) meeting the Rome criteria and normal testing of upper endoscopy and abdominal sonography.

Methods: We retrospectively included patients who underwent HBT (lactose, fructose, or glucose) between 2006 and 2012 and who had symptoms of FD. Patients were divided into 2 groups according to medical history and diagnostic results: (I) patients with suspected FD according to the Rome III criteria and (II) patients with an alternative diagnosis such as gastroesophageal reflux disease (GERD) or Crohn's disease (CD). Read More

View Article
November 2018
3 Reads

Milky Mesentery: Acute Abdomen with Chylous Ascites.

Indian Pediatr 2018 Oct;55(10):909-910

Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, Shahdara, Delhi, India.

Background: Clinical presentations of intestinal lymphangiectasia include pitting edema, chylous ascites, pleural effusion, diarrhea, malabsorption and intestinal obstruction.

Case Characteristics: An 8-year-old male child presented to the emergency department with clinical features of peritonitis, raising suspicion of appendicular or small bowel perforation.

Intervention/outcome: Diagnosis of chylous ascites with primary intestinal lymphangiectasia made on laparotomy. Read More

View Article
October 2018
4 Reads

Nutrition in Pediatric Chronic Liver Disease.

Pediatr Ann 2018 Nov;47(11):e445-e451

More than one-half of children with chronic liver disease suffer from malnutrition, which leads not only to a poor quality of life and even possibly catastrophic complications, but also to poor outcomes after a liver transplantation. These children have increased metabolic demands but often decreased intake with malabsorption and altered nutrient utilization, all of which make it difficult to keep up with nutritional demands. Assessment of a patient's nutritional status should be timely, and it should be performed routinely and proactively. Read More

View Article
November 2018
4 Reads

Cholestyramine decreases apparent total tract macronutrient digestibility and alters fecal characteristics and metabolites of healthy adult dogs.

J Anim Sci 2018 Nov 13. Epub 2018 Nov 13.

Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL.

Absorption of dietary lipids in the small intestine is dependent on the emulsification by bile acids (BA) and the formation of chylomicrons. Cholestyramine is a common drug used in humans - and potentially dogs - to treat BA malabsorption associated with chronic diarrhea. It is known to bind BA to form insoluble complexes, preventing their reabsorption and possibly proper emulsification and absorption of dietary fats. Read More

View Article
November 2018
9 Reads

Eculizumab Is Safe and Effective as a Long-term Treatment for Protein-losing Enteropathy Due to CD55 Deficiency.

J Pediatr Gastroenterol Nutr 2018 Nov 8. Epub 2018 Nov 8.

The Genetics Institute, Rambam Health Care Campus.

Objectives: Loss of the complement inhibitor CD55 leads to a syndrome of early-onset protein-losing enteropathy (PLE), associated with intestinal lymphangiectasia and susceptibility to large-vein thrombosis. The in vitro and short-term treatment benefits of eculizumab (C5-inhibitor) therapy for CD55-deficiency have been previously demonstrated. Here we present the 18-months treatment outcomes for 3 CD55-deficiency patients with sustained therapeutic response. Read More

View Article
November 2018
4 Reads

Oral L-thyroxine liquid versus tablet in patients submitted to total thyroidectomy for thyroid cancer (without malabsorption): A prospective study.

Laryngoscope Investig Otolaryngol 2018 Oct 3;3(5):405-408. Epub 2018 Oct 3.

Department of Clinical and Experimental Medicine University of Pisa Pisa Italy.

Objective: No consistent data are present in literature about the effectiveness of Levothyroxine (L-T4) liquid formulation in patients without malabsorption after thyroidectomy. The aim of this study is to compare the effectiveness of L-T4 liquid formulation, with L-T4 tablets, in thyroid cancer patients after thyroidectomy (without malabsorption or drug interference).

Methods: One hundred five patients were recruited; 52 patients were treated with liquid L-T4 formulation, while 53 with L-T4 tablets, at the same dosage (1. Read More

View Article
October 2018
3 Reads

Congenital glucose-galactose malabsorption: A rare and severe cause of infant diarrhea.

Med Clin (Barc) 2018 Nov 5. Epub 2018 Nov 5.

Servicio de Gastroenterología, Hepatología y Nutrición Pediátricas, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.

View Article
November 2018

Digestive side-effects with teriflunomide: Thoughts on lactose.

Rev Neurol (Paris) 2018 Dec 5;174(10):722-725. Epub 2018 Nov 5.

Centre de ressources et compétences SEP, neurologie, université Nice-Côte-d'Azur, CHU Pasteur 2, 30, voie Romaine, 06002 Nice, France.

Introduction: Teriflunomide, a novel, orally bioavailable, active metabolite of leflunomide, has anti-inflammatory activity. It is prescribed as a first-line treatment for relapsing-remitting multiple sclerosis (RRMS) at a dose of one 14mg tablet per day. Common adverse reactions observed in placebo-controlled trials with a frequency≥10% and a rate twofold or more than reported with placebo, include digestive disorders. Read More

View Article
December 2018
9 Reads

Pancrelipase-Induced Hypersensitivity Reaction: Case Report and Review of Literature.

JOP 2018 Sep;19(5):273-275

Tufts University School of Medicine, Boston, MA, 02111.

Introduction: Drug-induced exanthems are commonly associated with NSAIDs, antibiotics, and anti-epileptics. Pancrelipase is frequently used for conditions resulting in pancreatic exocrine insufficiency. Published case reports of pancrelipase hypersensitivity focus on the respiratory manifestations. Read More

View Article
September 2018
1 Read

Evaluation of condylar structures on panoramic radiographs in adolescent patients with celiac disease.

Folia Morphol (Warsz) 2018 Nov 7. Epub 2018 Nov 7.

Adiyaman University, Turkey.

Background: Celiac disease (CD) is a common disorder that usually originates from calcium malabsorption. Thus, it is accepted that patients with CD have lower bone mineral density than that of healthy individuals. The aim of this study was to assess condylar height, width, area, and perimeter on digital panoramic radiographs in patients with CD. Read More

View Article
November 2018
1 Read

Lipid and Bile Acid Dysmetabolism in Crohn's Disease.

J Immunol Res 2018 1;2018:7270486. Epub 2018 Oct 1.

Department of Public Health, Dokkyo Medical University School of Medicine, Tochigi 321-0293, Japan.

Crohn's disease is one of the systemic autoimmune diseases. It commonly affects the small intestine and colon but may involve any portion of the gastrointestinal tract from the mouth to the anus. The most affected area by Crohn's disease is the distal part of the small intestine, in which the bile acid molecules are most efficiently reabsorbed. Read More

View Article
November 2018
8 Reads

Noninvasive biomarkers of gut barrier function identify two subtypes of patients suffering from diarrhoea predominant-IBS: a case-control study.

BMC Gastroenterol 2018 Nov 6;18(1):167. Epub 2018 Nov 6.

Laboratory of Nutritional Pathophysiology, National Institute of Gastroenterology, "S. de Bellis" Research Hospital, Via Turi 27, I-70013 Castellana Grotte, Bari, Italy.

Background: Alterations of the small-intestinal permeability (s-IP) might play an essential role in both diarrhoea-predominant IBS (D-IBS) and celiac disease (CD) patients. Our aims were to analyse in D-IBS patients the symptom profile along with the levels of urinary sucrose (Su), lactulose (La), mannitol (Ma), and circulating biomarkers (zonulin, intestinal fatty acid binding protein - I-FABP, and diamine oxidase - DAO) of the gastrointestinal (GI) barrier function. The pro-inflammatory interleukins 6 and 8 (IL-6 and IL-8), the plasma values of lipopolysaccharide (LPS), and Toll-like receptor 4 (TLR-4) were also investigated. Read More

View Article
November 2018
5 Reads

Trichohepatoenteric syndrome: A rare mutation in SKIV2L gene in the first Balkan reported case.

SAGE Open Med Case Rep 2018 30;6:2050313X18807795. Epub 2018 Oct 30.

2nd Pathologic Propaedeutic Clinic, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Trichohepatoenteric syndrome or syndromic diarrhea is a rare and severe Mendelian autosomal recessive syndrome characterized by intractable diarrhea, facial and hair abnormalities, liver dysfunction, immunodeficiency and failure to thrive. It has been associated with mutations in TTC37 and SKIV2L genes, which encode proteins of the SKI complex that contributes to the cytosolic degradation of the messenger RNA by the cell's exosome. We report a case of a male infant who suffered from typical symptoms and signs of trichohepatoenteric syndrome without immunodeficiency. Read More

View Article
October 2018
9 Reads

Repeatability and effect of blinding of fructose breath tests in patients with functional gastrointestinal disorders.

Neurogastroenterol Motil 2018 Nov 4:e13497. Epub 2018 Nov 4.

Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.

Background: Breath tests are used as measures of sugar intolerance or malabsorption in patients with functional gastrointestinal disorders (FGID), although the repeatability or anticipatory bias have not been adequately studied. We examined the repeatability and anticipatory bias during fructose breath testing using a nocebo-controlled, randomized, cross-over, and double-blind study design.

Methods: Gastrointestinal symptoms and breath concentrations of hydrogen and methane were documented during breath tests with fructose (given open twice and blinded once), water (blind neutral nocebo) and a cyclamate/saccharine sweetener (blind sweet nocebo) on 5 days in patients with FGID. Read More

View Article
November 2018
3 Reads

Home parenteral support in patients with incurable cancer. Patient characteristics of importance for catheter related complications and overall survival.

Clin Nutr ESPEN 2018 Dec 12;28:88-95. Epub 2018 Oct 12.

Department of Medical Gastroenterology, Odense University Hospital, Denmark; Institute of Clinical Research, University of Southern Denmark, Denmark. Electronic address:

Purpose: It is uncertain if home parenteral support (HPS) is of advantage in patients with incurable cancer and intestinal failure, functional obstruction or severe malabsorption. From a single centre cohort we present characteristics of patients with incurable cancer treated with HPS.

Methods: Over a ten year period (2005-2015) data were retrospectively collected on patients with incurable cancer discharged on HPS from a Danish tertiary referral centre. Read More

View Article
December 2018
4 Reads

Effects of branched chain amino acid supplementation on patient care outcomes in adults and children with liver cirrhosis: A systematic review.

Clin Nutr ESPEN 2018 Dec 14;28:41-51. Epub 2018 Aug 14.

Department of Agricultural, Food & Nutritional Sciences, University of Alberta, Canada; Department of Pediatrics, University of Alberta, Canada. Electronic address:

Background & Aims: Malnutrition is highly prevalent in chronic liver disease (CLD) due to alterations in nutrient utilization, malabsorption and poor intake. Low serum concentrations of branched chain amino acids (BCAA) in the presence of elevated aromatic acid concentrations is commonly observed in adult and children with liver cirrhosis and is associated with malnutrition and other adverse patient outcomes. The efficacy of BCAA supplementation has not been well established in adults and children with CLD. Read More

View Article
December 2018
1 Read

Improving basic skills in celiac-like disease diagnosis: a case report.

BMC Gastroenterol 2018 Nov 3;18(1):162. Epub 2018 Nov 3.

Gastroenterology and Gastrointestinal Endoscopy Unit, Sant'Andrea University Hospital, "Sapienza" University of Rome, Rome, Italy.

Background: The diagnosis of Coeliac disease (CD) requires a combination of sign/symptoms, positivity of specific antibodies and duodenal histological evidence of villous atrophy. Duodenal villous atrophy, despite representing the CD landmark, is not specific since it is found in many gastrointestinal disorders. Giardiasis is one of the most common human intestinal protozoan infestations in industrialized countries whose histological duodenal mucosa damage could mimic that of CD. Read More

View Article
November 2018
2 Reads

Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on Current Management and Future Perspectives.

Nutrients 2018 Nov 1;10(11). Epub 2018 Nov 1.

Allergy Therapeutics Italia, via IV Novembre 76, 20190 Milano, Italy.

Milk is a fundamental component of the diet of every mammal; nevertheless, not every individual can tolerate this kind of food, especially in adulthood. However, lactose intolerance has only been recognized in the last 50 years, and currently, lactose intolerance is defined as a clinical syndrome characterized by pain, abdominal distention, flatulence, and diarrhoea that occur after lactose consumption. Lactose is currently a common disaccharide in human nutrition, both in breastfed infants and in adults, but its digestion requires a specialized enzyme called lactase. Read More

View Article
November 2018
8 Reads

Nutritional support in chronic liver disease and cirrhotics.

World J Hepatol 2018 Oct;10(10):685-694

Undergraduate Medicine, McMaster University, Hamilton, ON L8S4L8, Canada.

The liver is a major organ and an essential component in maintaining an appropriate nutritional status in healthy individuals through metabolism of protein, carbohydrates, and fat. In individuals with chronic liver disease (CLD), along with a number of other essential functions that the liver serves, its role in nutrition maintenance is severely impaired. Common causes of CLD include hepatitis C, alcoholic liver disease, and non-alcoholic liver disease. Read More

View Article
October 2018
1 Read

Bile acid malabsorption is associated with diarrhea in acute phase of colitis.

Can J Physiol Pharmacol 2018 Dec 1;96(12):1328-1336. Epub 2018 Nov 1.

a School of Pharmaceutical, Shanxi Medical University, Shanxi 030000 China.

The enterohepatic circulation of bile acids (BAs) critically depends on BA transporters and enzymes, which can be affected by inflammatory bowel disease. Diarrhea in colitis is believed to result in part from BA malabsorption. The work aimed to investigate whether diarrhea in colitis was associated with the expression of BA transporters, enzymes, and nuclear receptors. Read More

View Article
December 2018
1 Read

Genetic and environmental factors affecting the expression of α-gliadin canonical epitopes involved in celiac disease in a wide collection of spelt (Triticum aestivum ssp. spelta) cultivars and landraces.

BMC Plant Biol 2018 Nov 1;18(1):262. Epub 2018 Nov 1.

Unit of Bioengineering, Department of Life Sciences, Walloon Agricultural Research Center, Gembloux, Belgium.

Background: Celiac disease (CD) is an autoimmune disorder affecting genetically predisposed individuals whose dietary gluten proteins trigger an inflammatory reaction in the small intestine. Gluten is found in the seeds of cereals like bread wheat (Triticum aestivum ssp. aestivum) and spelt (Triticum aestivum ssp. Read More

View Article
November 2018
2 Reads

L-thyroxine malabsorption due to calcium carbonate impairs blood pressure, total cholesterolemia, and fasting glycemia.

Endocrine 2018 Oct 27. Epub 2018 Oct 27.

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Purpose: Calcium carbonate was previously shown to interfere with L-thyroxine absorption. To estimate the magnitude of tablet L-thyroxine malabsorption caused by calcium carbonate, with resulting increase in serum thyrotropin (TSH), we performed a cohort study in a referral care center.

Methods: Fifty postmenopausal hypothyroid L-thyroxine-treated women (age 71. Read More

View Article
October 2018
4 Reads

Celiac Disease in the Pediatric Population.

J Pediatr Health Care 2018 Nov - Dec;32(6):627-631

Celiac disease is an autoimmune disorder in which the lining of the gastrointestinal tract is damaged by an immune-mediated response to gluten proteins (Allen, 2015). It is a polygenetic disease that only appears in genetically susceptible individuals (Newton & Singer, 2012). It is a worldwide concern, with North America having a high prevalence rate (Liu et al. Read More

View Article
December 2017
13 Reads

Jaundice revisited: recent advances in the diagnosis and treatment of inherited cholestatic liver diseases.

J Biomed Sci 2018 Oct 26;25(1):75. Epub 2018 Oct 26.

Departments of Pediatrics, National Taiwan University College of Medicine and Children's Hospital, 17F, No. 8, Chung Shan S. Rd, Taipei, 100, Taiwan.

Background: Jaundice is a common symptom of inherited or acquired liver diseases or a manifestation of diseases involving red blood cell metabolism. Recent progress has elucidated the molecular mechanisms of bile metabolism, hepatocellular transport, bile ductular development, intestinal bile salt reabsorption, and the regulation of bile acids homeostasis.

Main Body: The major genetic diseases causing jaundice involve disturbances of bile flow. Read More

View Article
October 2018
11 Reads

Position of the Academy of Nutrition and Dietetics: Micronutrient Supplementation.

J Acad Nutr Diet 2018 Nov;118(11):2162-2173

It is the position of the Academy of Nutrition and Dietetics that micronutrient supplements are warranted when requirements are not being met through the diet alone. Those with increased requirements secondary to growth, chronic disease, medication use, malabsorption, pregnancy and lactation, and aging may be at particular risk for inadequate dietary intakes. However, the routine and indiscriminate use of micronutrient supplements for the prevention of chronic disease is not recommended, given the lack of available scientific evidence. Read More

View Article
November 2018
11 Reads

Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation in -Deficient Intestinal Organoids.

Cell Mol Gastroenterol Hepatol 2018 14;6(4):477-493.e1. Epub 2018 Aug 14.

German Cancer Consortium (Deutsches Konsortium für Translationale Krebsforschung), Heidelberg, Germany.

Background & Aims: Microvillus inclusion disease (MVID) is a congenital intestinal malabsorption disorder caused by defective apical vesicular transport. Existing cellular models do not fully recapitulate this heterogeneous pathology. The aim of this study was to characterize 3-dimensional intestinal organoids that continuously generate polarized absorptive cells as an accessible and relevant model to investigate MVID. Read More

View Article
August 2018
6 Reads

Nutritional Deficiencies after Gastric Bypass: Mechanisms Involved and Strategies to Improve Oral Supplement Disposition.

Curr Drug Metab 2018 Oct 26. Epub 2018 Oct 26.

Diabetes Complications Research Centre, Conway Institute, University College Dublin, Dublin. Ireland.

Background: Nutritional deficiencies are common following Roux-en-Y gastric bypass (RYGB). Aetiology is diverse; including unresolved preoperative deficiency, post-operative malabsorption and reduced food intake. Iron and calcium/vitamin D deficiency are particularly troublesome following RYGB. Read More

View Article
October 2018
1 Read

A Systematic Review of Probiotics for Cystic Fibrosis Patients: Moving Forward.

J Pediatr Gastroenterol Nutr 2018 Oct 24. Epub 2018 Oct 24.

Instituto da Criança - Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo.

Background: Cystic fibrosis (CF) is associated with chronic respiratory disease and pancreatic insufficiency and results in the malabsorption of nutrients and intestinal inflammation. There is evidence that probiotic supplementation may impact the gastrointestinal and respiratory microbiota. This study aimed to categorize current evidence regarding the effects of supplementing with probiotics in CF patients on gastrointestinal and respiratory outcomes according to the type of intervention. Read More

View Article
October 2018
3 Reads

[Yogurt and dietary recommendations for lactose intolerance].

Nutr Hosp 2018 Sep 7;35(Spec No6):45-48. Epub 2018 Sep 7.

.

Malabsorption to lactose is caused by the inability to digest sugar due to the decrease in the activity of intestinal lactase. Malabsorption may be due to a primary or secondary disorder. Adult type primary hypolactasia is an autosomal recessive disorder, characterized by the progressive loss of lactase after weaning. Read More

View Article
September 2018
2 Reads