43,844 results match your criteria Malabsorption


Anastomotic leakage with abscess: Neglected severe complication of bariatric surgery for obesity: A case report.

Int J Surg Case Rep 2019 Feb 12;55:227-229. Epub 2019 Feb 12.

Department of Oncology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.

Introduction: Presently, bariatric surgery is a widespread treatment for obesity and its co-morbidities. Comprehensive evidence from outcomes of bariatric surgery supported that the surgery is safe and effective. However, we should be aware of the multiple risks of bariatric surgery, especially the severe infection at the operation site. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.010DOI Listing
February 2019

Case Report on a Rare Disease in Lithuania: Congenital Chloride Diarrhea.

J Pediatr Genet 2019 Mar 25;8(1):24-26. Epub 2018 Aug 25.

Department of Genetics and Molecular Medicine, Hospital of Lithuanian University of Health Sciences, Kaunas, Lithuania.

Congenital chloride diarrhea (CCD) is a rare disease, manifesting with secretory diarrhea and life-threatening electrolyte imbalance during infancy. The early diagnosis of CCD is therefore necessary for the adequate treatment. The long-term prognosis of properly managed CCD is favorable. Read More

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http://dx.doi.org/10.1055/s-0038-1669437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375714PMC

Duodenal switch: Fully stapled technique.

Surg Obes Relat Dis 2019 Jan 22. Epub 2019 Jan 22.

Bariatric Surgeon, North Carolina Surgery, Rex Hospital, Raleigh, North Carolina.

Background: Duodenal switch and single anastomosis modifications continue to gain greater interest among bariatric surgeons. Limiting factors to adoption include concerns around the nutritional management, patient compliance and follow-up, and the technical challenge of the operation. The majority of techniques offered currently use a hand-sewn duodenoileostomy. Read More

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http://dx.doi.org/10.1016/j.soard.2018.12.031DOI Listing
January 2019

Whipple's Disease: A Case Report.

Med Princ Pract 2019 Feb 14. Epub 2019 Feb 14.

Objective

Whipple's disease is a very rare systemic infectious disease, with an incidence of 1 in one million, which may be fatal if not diagnosed and treated appropriately.

Clinical Presentation and Intervention

Herein we will describe a 49 years old male patient admitted to the hospital with the signs of severe malabsorption and diagnosed with Whipple's disease.

Conclusion

We aimed to emphasize the Whipple's disease to be kept in mind for the prompt diagnosis and treatment of patients with malabsorption. Read More

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http://dx.doi.org/10.1159/000498909DOI Listing
February 2019
3 Reads

Helicobacter pylori and nutrition: a bidirectional communication.

Minerva Gastroenterol Dietol 2019 Feb 12. Epub 2019 Feb 12.

Unit of Dietetics and Clinical Nutrition, Città della Salute e della Scienza, Turin, Italy.

Helicobacter pylori (HP) is a gram negative flagellated pathogen acid-resistant bacterium; it belongs to the order Campylobacterales that is wide spread all over the world, infecting more than 50% of the world population. HP infection is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and with 3 to 6-fold increased relative risk for developing gastric adenocarcinoma and mucosa-associated lymphoid tissue (MA LT) lymphoma. For this reason HP is recognized by the World Health Organization as a Class I human carcinogen. Read More

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https://www.minervamedica.it/index2.php?show=R08Y9999N00A190
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http://dx.doi.org/10.23736/S1121-421X.19.02568-6DOI Listing
February 2019
1 Read

Bile Acid Synthesis Disorder Masquerading as Intractable Vitamin D-Deficiency Rickets.

J Endocr Soc 2019 Feb 31;3(2):397-402. Epub 2018 Dec 31.

Division of Pediatric Endocrinology and Metabolism, Children's of Alabama, University of Alabama at Birmingham, Birmingham, Alabama.

Vitamin D-deficiency rickets, not responding to large treatment doses of oral vitamin D, suggest rare receptor mutations, malabsorption, or hepatobiliary dysfunction. We present a set of twins of Hispanic origin who presented with refractory vitamin D-deficiency rickets and failure to thrive (FTT) at 6 months of age. On follow-up, mild elevations in serum alanine transaminases and normal aspartate aminotransferase were noted. Read More

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http://dx.doi.org/10.1210/js.2018-00314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364623PMC
February 2019
1 Read

Celiac crisis, a rare occurrence in adult celiac disease: A systematic review.

World J Clin Cases 2019 Feb;7(3):311-319

Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania.

Background: Celiac crisis (CC), a potentially life-threatening condition, is one of the rare clinical presentations of celiac disease (CD). Several cases have been documented in the literature, mostly in children.

Aim: To perform a review of CC cases reported in adult CD patients. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i3.311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369385PMC
February 2019
1 Read

Se-Homocholic acid taurine scintigraphy (SeHCAT), a standard benchmark test in bile acid malabsorption?

Rev Esp Med Nucl Imagen Mol 2019 Feb 7. Epub 2019 Feb 7.

Servicio de Medicina Nuclear, Hospital Universitario Puerta del Mar, Cádiz, España.

Chronic diarrhoea due to bile acid malabsorption (BAM) is an underdiagnosed pathology. Different diagnostic tools are available. However, there is currently no consensus on which of these would be the benchmark test or gold standard. Read More

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http://dx.doi.org/10.1016/j.remn.2018.12.005DOI Listing
February 2019

Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis.

Front Neurosci 2019 25;13. Epub 2019 Jan 25.

Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.

Subacute combined degeneration (SCD) is a relatively rare myelopathy mainly caused by vitamin B (VitB12) deficiency. There are many causes contributing to VitB12 deficiency. Autoimmune gastritis might lead to severe VitB12 malabsorption and in its advanced stage pernicious anemia (PA) may occur. Read More

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http://dx.doi.org/10.3389/fnins.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355687PMC
January 2019
1 Read

Treating Severe GERD and Obesity with a Sleeve Gastrectomy with Cardioplication and a Transit Bipartition.

Obes Surg 2019 Feb 8. Epub 2019 Feb 8.

Gastroenterology Department, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627. Morumbi, São Paulo, SP, 050652-900, Brazil.

Introduction: Epidemiological data have demonstrated that obesity is an important risk factor for the development of gastroesophageal reflux disease (GERD). The proportion of subjects with GERD symptoms can be as high as 50% for BMI > 30. Although still controversial in the literature, there are several studies associating sleeve gastrectomy (SG) with an increase in GERD prevalence. Read More

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http://link.springer.com/10.1007/s11695-019-03752-4
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http://dx.doi.org/10.1007/s11695-019-03752-4DOI Listing
February 2019
2 Reads

Off-Label Teduglutide Therapy in Non-intestinal Failure Patients with Chronic Malabsorption.

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, 840 S Wood St (M/C 716), Chicago, IL, 60612, USA.

Background: Teduglutide, a glucagon-like peptide 2 analog, has demonstrated efficacy in treating adult patients with short bowel syndrome (SBS) and dependence on parenteral nutrition (PN), but its role in chronic malabsorptive states that do not necessitate PN remains uncertain.

Aims: To evaluate teduglutide use beyond its approved indications and to discuss the results of this adjunctive treatment in patients resistant to established therapy.

Results: This series reports four patients treated with teduglutide off-label. Read More

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http://dx.doi.org/10.1007/s10620-019-5473-5DOI Listing
February 2019
1 Read

Prevalence and associated factors of small intestinal bacterial overgrowth among systemic sclerosis patients.

Int J Rheum Dis 2019 Feb 6. Epub 2019 Feb 6.

Faculty of Medicine, Division of Allergy-Immunology-Rheumatology, Department of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: Small intestinal bacterial overgrowth (SIBO) results in nutrient malabsorption and malnutrition, thereby increasing the morbidity and mortality in systemic sclerosis (SSc) patients.

Objectives: To evaluate the prevalence and associated factors of SIBO in SSc patients.

Method: A cross-sectional study was conducted between July 2015 and January 2016 in SSc patients over 18, using the glucose H /CH breath test to evaluate SIBO. Read More

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http://dx.doi.org/10.1111/1756-185X.13495DOI Listing
February 2019
1 Read

GLP-1 mediated improvement of the glucose tolerance in the T2DM GK rat model after massive jejunal resection.

Ann Anat 2019 Feb 2;223:1-7. Epub 2019 Feb 2.

Department of Human Anatomy and Embryology, Faculty of Medicine, University of Cádiz.

Objective: The aim of this study was to clarify the role of the middle gut in the entero-pancreatic axis modification that leads to glucose improvement in the Goto-Kakizaki (GK) rat as a non-obese T2DM model.

Background: Bariatric surgery is considered an assured solution for type 2 Diabetes (T2DM). Enterohormones such as ghrelin, gastric inhibitory polypeptide and mainly glucagon-like peptide-1 (GLP-1) were recognized as key players in the physiophathological mechanisms associated with entero-pancreatic axis regulation and glucose tolerance improvement. Read More

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http://dx.doi.org/10.1016/j.aanat.2019.01.007DOI Listing
February 2019
2 Reads

Clinical evaluation and treatment of chronic bowel symptoms following cancer in the colon and pelvic organs.

Acta Oncol 2019 Jan 30:1-6. Epub 2019 Jan 30.

a Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects After Cancer in the Pelvic Organs , Aarhus University Hospital , Aarhus , Denmark.

Background: Chronic gastrointestinal symptoms are common among patients surviving surgery and/or radio-/chemotherapy for cancer in the pelvic organs. However, little is known about the pathophysiology behind symptoms or the effect of treatment. The aim of the present study was to present the results of clinical evaluation and treatment of patients with chronic bowel symptoms after treatment for cancer in the colon or pelvic organs. Read More

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https://www.tandfonline.com/doi/full/10.1080/0284186X.2018.1
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http://dx.doi.org/10.1080/0284186X.2018.1562211DOI Listing
January 2019
4 Reads

A rare presentation of hypovolemic shock secondary to Whipple's disease.

Eur J Gastroenterol Hepatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Medicine, Division of Gastroenterology, Mount Sinai Hospital, University of Toronto.

Whipple's disease is a rare, multisystem infection caused by the Gram-positive Tropheryma whippelii organism. In addition to neurological and rheumatological manifestations, this disease can result in significant gastrointestinal symptoms such as malabsorption, diarrhea, and weight loss. Given the diagnostic challenge and rare occurrence, a high index of suspicion is critical to prevent morbidity and mortality from this otherwise highly infectious disease transmitted via the fecal-oral route. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001363DOI Listing
January 2019
1 Read

Gluten-free products in celiac disease: Nutritional and technological challenges and solutions.

J Res Med Sci 2018 28;23:109. Epub 2018 Dec 28.

Department of Food Science and Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

In celiac patient exposure to even only a small amount of gluten can lead to malabsorption of some important nutrients including calcium, iron, folic acid, and fat-soluble vitamins because of small-intestine inflammation. A strictly followed gluten-free (GF) diet throughout the patient's lifetime is the only effective treatment for celiac disease; however, elimination of gluten from cereal-based product leads to many technological and nutritional problems. This report discusses different substitutes to replace gluten functionality and examines the economic and social impacts of adherence to a GF diet. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_666_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327684PMC
December 2018
2 Reads

Functions and Applications of Bioactive Peptides From Corn Gluten Meal.

Adv Food Nutr Res 2019 31;87:1-41. Epub 2018 Aug 31.

Beijing Engineering Research Center of Protein & Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing, PR China. Electronic address:

Corn protein has been identified as an important source of bioactive peptides. Such peptides can be released during hydrolysis induced by proteolytic enzymes or microbial fermentation. Corn peptides have been found to exhibit different functions in vitro and in vivo such as antihypertensive, hepatoprotective, anti-obesity, antimicrobial, antioxidative, mineral-binding and accelerating alcohol metabolism. Read More

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http://dx.doi.org/10.1016/bs.afnr.2018.07.001DOI Listing

Combining Acute Kidney Injury with Gastrointestinal Pathology: A Clue to Acute Oxalate Nephropathy.

Case Rep Nephrol 2018 23;2018:8641893. Epub 2018 Dec 23.

Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Acute oxalate nephropathy (AON) is an increasingly recognized cause of acute kidney injury (AKI). Herein, we present two cases of biopsy-proven acute oxalate nephropathy in patients with gastrointestinal malabsorption, coincidentally both stemming from cholangiocarcinoma. The first is a 73-year-old male who presented with syncope and was found to have severe, oliguric AKI in the setting of newly diagnosed, nonresectable cholangiocarcinoma. Read More

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http://dx.doi.org/10.1155/2018/8641893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323504PMC
December 2018
1 Read

Laparoscopic Revision of Failed Bariatric Procedures.

JSLS 2019 Jan-Mar;23(1)

Chicago Institute of Minimally Invasive Surgery, Skokie, Illinois, USA.

Background: The main indications for revision of bariatric surgery are inadequate weight loss, weight regain, or complications. The objective of revision is to restore the restrictive component and/or add a malabsorptive component.

Objectives: To evaluate the effectiveness of revisional laparoscopic bariatric surgery for loss of weight and assess the risks and benefits associated with these technically demanding procedures. Read More

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328359/
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http://dx.doi.org/10.4293/JSLS.2018.00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328359PMC
January 2019
4 Reads

[Glucose and galactose malabsorption: A new case in Spain].

An Pediatr (Barc) 2019 Jan 18. Epub 2019 Jan 18.

Grupo de Investigación en Enfermedades Raras, Unidad Neonatal, Servicio de Pediatría, Instituto de Investigación Sanitaria BioAraba, OSI Araba, Vitoria-Gasteiz, España.

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http://dx.doi.org/10.1016/j.anpedi.2018.12.006DOI Listing
January 2019

Liver Transplantation for Fulminant Hepatic Failure Due to Heat Stroke: A Case Report.

Transplant Proc 2019 Jan - Feb;51(1):87-89. Epub 2018 Jun 30.

Liver Transplant Unit, Department of Surgery, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB-Arrixaca, Murcia, Spain.

Heat stroke is a condition caused by an excessive increase in body temperature in a relatively short period of time, and is clinically characterized by central nervous system dysfunction, including delirium, seizures, coma, and severe hyperthermia. In this context, the resulting fulminant hepatic failure makes liver transplant the best choice when there are no guarantees of better results with conservative treatment. We present our experience in this case, possible alternative choices, and the current role of liver transplantation in the resolution of fulminant liver failure due to heat stroke. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.03.137DOI Listing
June 2018
2 Reads

Congenital glucose-galactose malabsorption: A case report with a novel mutation.

Clin Case Rep 2019 Jan 11;7(1):51-53. Epub 2018 Nov 11.

Department of Pediatrics, School of Medicine The university of Jordan Amman Jordan.

A three-day-old newborn girl presented with decreased feeding and dehydration. She was sick and in shock. She had renal impairment and hypernatremia. Read More

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http://doi.wiley.com/10.1002/ccr3.1913
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http://dx.doi.org/10.1002/ccr3.1913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333054PMC
January 2019
14 Reads

Defective FXR-FGF15 signaling and bile acid homeostasis in cystic fibrosis mice can be restored by the laxative polyethylene glycol.

Am J Physiol Gastrointest Liver Physiol 2019 Jan 17. Epub 2019 Jan 17.

Section of Molecular Metabolism and Nutrition, Laboratory of Pediatrics, University of Groningen, Netherlands.

The gastrointestinal phenotype of cystic fibrosis (CF) features intestinal bile acid (BA) malabsorption, impaired intestinal farnesoid X receptor (FXR) activation and consequently reduced fibroblast growth factor 19 (FGF19, FGF15 in mice) production. The osmotic laxative polyethylene glycol (PEG) has been shown to decrease intestinal mucus accumulation in CF mice and could, by doing so, improve BA reabsorption. Here we determined the effect of PEG on BA excretion and FXR-FGF15 signaling in CF mice. Read More

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https://www.physiology.org/doi/10.1152/ajpgi.00188.2018
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http://dx.doi.org/10.1152/ajpgi.00188.2018DOI Listing
January 2019
9 Reads

What is the cost of delayed diagnosis of bile acid malabsorption and bile acid diarrhoea?

Frontline Gastroenterol 2019 Jan 26;10(1):72-76. Epub 2018 Jul 26.

Department of Gastroenterology, Lincoln County Hospital, Lincoln, UK.

Introduction: Selenium taurocholic acid (SeHCAT) scanning diagnoses bile acid malabsorption/bile acid diarrhoea (BAM/BAD) and defines optimal treatment. Approximately 2% of the population have BAM/BAD.

Aim: To evaluate the cost of delayed diagnosis of BAM/BAD. Read More

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http://dx.doi.org/10.1136/flgastro-2018-101011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319159PMC
January 2019
1 Read

Gluten-Free Diet: Gaps and Needs for a Healthier Diet.

Nutrients 2019 Jan 15;11(1). Epub 2019 Jan 15.

CREA Research Centre for Food and Nutrition; Via Ardeatina 546, I-00178 Rome, Italy.

The gluten-free diet (GFD) is currently the only effective treatment in remitting the symptoms of coeliac disease (CD), a chronic systemic autoimmune disorder caused by a permanent intolerance to gluten proteins in genetically susceptible individuals. The diet entails the substitution of gluten-containing products with gluten-free-rendered products. However, over recent decades the nutritional profile of gluten-free (GF) food products has been increasingly questioned within the scientific community. Read More

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http://dx.doi.org/10.3390/nu11010170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357014PMC
January 2019

The Spectrum of Small Intestinal Bacterial Overgrowth (SIBO).

Curr Gastroenterol Rep 2019 Jan 15;21(1). Epub 2019 Jan 15.

Lynda K and David M Underwood Center for Digestive Disorders, Division of Gastroenterology and Hepatology, Houston Methodist Hospital, Weill Cornell Medical College, Houston, TX, USA.

Purpose Of Review: To critically review recent (past 3 years) literature on the definition, diagnosis, and management of small intestinal bacterial overgrowth (SIBO).

Recent Findings: While various series continue to illustrate the occurrence of SIBO in disease states where well-known risk factors for its occurrence are present (hypochlorhydria, disorders of intestinal structure or motor function, pancreatic insufficiency, and chronic liver disease, for example), the current challenge is in defining the limits of SIBO. Is SIBO truly common among those with "functional" gastrointestinal symptoms where there is no evidence of maldigestion or malabsorption; the original hallmarks of SIBO? Our attempts to address this question continue to be hampered by the limitations of our diagnostic tool kit. Read More

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http://dx.doi.org/10.1007/s11894-019-0671-zDOI Listing
January 2019
6 Reads

Th17 cell frequency is associated with low bone mass in primary sclerosing cholangitis.

J Hepatol 2019 Jan 11. Epub 2019 Jan 11.

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany; Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany. Electronic address:

Background & Aims: Osteoporotic fractures are a major cause of morbidity and reduced quality of life in patients with primary sclerosing cholangitis (PSC), a progressive bile duct disease of unknown origin. Although it is generally assumed that this pathology is a consequence of impaired calcium homeostasis and malabsorption, the cellular and molecular causes of PSC-associated osteoporosis are unknown.

Methods: We determined bone mineral density by dual-X-ray absorptiometry and assessed bone microstructure by high-resolution peripheral quantitative computed tomography in patients with PSC. Read More

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http://dx.doi.org/10.1016/j.jhep.2018.12.035DOI Listing
January 2019
1 Read

Chylomicron retention disease: genetics, biochemistry, and clinical spectrum.

Curr Opin Lipidol 2019 Jan 11. Epub 2019 Jan 11.

Research Centre.

Purpose Of Review: Chylomicron retention disease (CRD) is an autosomic recessive disorder, in which intestinal fat malabsorption is the main cause of diverse severe manifestations. The specific molecular defect was identified in 2003 and consists of mutations in the SAR1B or SARA2 gene encoding for intracellular SAR1B GTPase protein. The aim of this review is first to provide an update of the recent biochemical, genetic and clinical findings, and second to discuss novel mechanisms related to hallmark symptoms. Read More

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http://dx.doi.org/10.1097/MOL.0000000000000578DOI Listing
January 2019
1 Read

Symptoms that are associated with decreased pancreatic enzyme flow: MRCP assessment.

J Magn Reson Imaging 2019 Jan 13. Epub 2019 Jan 13.

Department of Radiology, Kawasaki Medical School, Kurashiki, Japan.

Background: Pancreatic exocrine insufficiency is one of the causes of malabsorption syndrome. In many cases of malabsorption syndrome, pancreatic exocrine insufficiency can be treated with pancreatic enzyme replacement therapy. Therefore, it is important to detect pancreatic endocrine insufficiency as early and accurately as possible. Read More

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http://dx.doi.org/10.1002/jmri.26619DOI Listing
January 2019

Exposure to Different Amounts of Dietary Gluten in Patients with Non-Celiac Gluten Sensitivity (NCGS): An Exploratory Study.

Nutrients 2019 Jan 10;11(1). Epub 2019 Jan 10.

Center for Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20135 Milan, Italy.

It is unclear whether patients with non-celiac gluten sensitivity (NCGS) can tolerate gluten. We have evaluated the changes of both gastrointestinal symptoms and quality of life for NCGS patients after the re-introduction of dietary gluten. Twenty-two NCGS patients reporting functional gastroenterological symptoms and on gluten-free diet (GFD) for the previous three weeks were exposed to incremental gluten-containing diets. Read More

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http://www.mdpi.com/2072-6643/11/1/136
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http://dx.doi.org/10.3390/nu11010136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356445PMC
January 2019
9 Reads

Hyperhomocysteinemia in men with a reproductive history of fetal neural tube defects: Three case reports and literature review.

Medicine (Baltimore) 2019 Jan;98(2):e13998

Center for Reproductive Medicine and prenatal diagnosis, First Bethune Hospital of Jilin University, Changchun, China.

Rationale: Hereditary hyperhomocysteinemia results from a polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene that reduces folate metabolism. Mutations in the MTHFR gene are common in parents who have given birth to children with neural tube defects (NTDs). Most research has focused on the risk for fetal NTDs in women with hyperhomocysteinemia and MTHFR gene mutations. Read More

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http://dx.doi.org/10.1097/MD.0000000000013998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336619PMC
January 2019
2 Reads

Coeliac disease.

Nat Rev Dis Primers 2019 Jan 10;5(1). Epub 2019 Jan 10.

Department of Internal Medicine, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Coeliac disease is an immune-mediated enteropathy against dietary gluten present in wheat, rye and barley and is one of the most common lifelong food-related disorders worldwide. Coeliac disease is also considered to be a systemic disorder characterized by a variable combination of gluten-related signs and symptoms and disease-specific antibodies in addition to enteropathy. The ingestion of gluten leads to the generation of harmful gluten peptides, which, in predisposed individuals, can induce adaptive and innate immune responses. Read More

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http://www.nature.com/articles/s41572-018-0054-z
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http://dx.doi.org/10.1038/s41572-018-0054-zDOI Listing
January 2019
6 Reads

Identifying and improving adherence to the gluten-free diet in people with coeliac disease.

Proc Nutr Soc 2019 Jan 11:1-8. Epub 2019 Jan 11.

Department of Life Sciences,University of Roehampton,London SW15 4JD,UK.

Coeliac disease (CD) is an autoimmune gastrointestinal disorder whereby the ingestion of gluten, a storage protein found in wheat, barley and rye, causes damage to intestinal mucosa with resultant malabsorption, increased risk of anaemia and osteoporosis. Worldwide estimates suggest 1% of the population have CD. With no cure, the only treatment is a gluten-free diet (GFD). Read More

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http://dx.doi.org/10.1017/S002966511800277XDOI Listing
January 2019
2 Reads

Risk factors for loss of bone mineral density after curative esophagectomy.

Arch Osteoporos 2019 Jan 9;14(1). Epub 2019 Jan 9.

Metabolic Medicine, University College Dublin, Conway Institute of Biomedical and Biomolecular Research, Dublin 4, Ireland.

Micronutrient and fat malabsorption and altered enteroendocrine signaling occur after esophagectomy for cancer; however, the impact of malnutrition on bone health in this cohort has not been previously investigated. In this study, the prevalence of osteoporosis increased after curative surgery, associated with disease-specific, treatment-related, and population risk factors.

Purpose: Improved oncologic outcomes in esophageal cancer (EC) have resulted in increased survivorship and a focus on long-term quality of life. Read More

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http://link.springer.com/10.1007/s11657-018-0556-z
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http://dx.doi.org/10.1007/s11657-018-0556-zDOI Listing
January 2019
5 Reads

Hypothyroidism associated with short bowel syndrome in children: a report of six cases.

Arch Endocrinol Metab 2018 ;62(6):655-660

Serviço de Cirurgia Pediátrica e Transplante Hepático, Laboratório de Investigação em Cirurgia Pediátrica (LIM-30), Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brasil.

Short bowel syndrome (SBS) is the leading cause of intestinal failure in children, a condition of absence of sufficient bowel to meet the nutritional and metabolic needs of a growing individual. The treatment of patients in this situation is based on the association of parenteral and enteral nutrition for prolonged periods of time until intestinal rehabilitation occurs with complete enteral nutrition autonomy. Six consecutive cases of children with SBS (residual intestinal length of 5 cm to 75 cm) were managed with this program and were diagnosed with associated hypothyroidism during the treatment (ages at the diagnosis 5 months to 12 years). Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.20945/2359-3997000000093DOI Listing
February 2019
7 Reads

Use of a Novel Probiotic Formulation to Alleviate Lactose Intolerance Symptoms-a Pilot Study.

Probiotics Antimicrob Proteins 2019 Jan 7. Epub 2019 Jan 7.

Gastroenterology Laboratory and the Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, 39 Jabotinsky Street, 4941492, Petah Tikva, Israel.

Lactose intolerance is a common condition caused by lactase deficiency and may result in symptoms of lactose malabsorption (bloating, flatulence, abdominal discomfort, and change in bowel habits). As current data is limited, the aim of our study was to assess the efficacy of probiotics with a β-galactosidase activity on symptoms of lactose malabsorption and on the lactose hydrogen breath test (LHBT). The study group comprised eight symptomatic female patients with a positive LHBT. Read More

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http://dx.doi.org/10.1007/s12602-018-9507-7DOI Listing
January 2019
1 Read

Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique.

Gastroenterol Res Pract 2018 26;2018:2097359. Epub 2018 Nov 26.

Department of New Technologies and Translational Research in Medicine and Surgery, Gastroenterology Unit, University of Pisa, Via Roma 67, 56122 Pisa, Italy.

Bile acid malabsorption (BAM) causing chronic diarrhea may be due to organic as well as functional disorders, and some of them were included under the general label of diarrheic-type irritable bowel syndrome (IBS-D). The 75-selenium homocholic acid taurine (SeHCAT) test is a nuclear medicine investigation considered to be the gold standard for the diagnosis of bile acid malabsorption (BAM). Many studies demonstrate that it could be effective in the clinical workout of chronic diarrhea due to different conditions. Read More

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http://dx.doi.org/10.1155/2018/2097359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287164PMC
November 2018
1 Read

Novel screening test for celiac disease using peptide functionalised gold nanoparticles.

World J Gastroenterol 2018 Dec;24(47):5379-5390

School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney 2007, Australia.

Aim: To develop a screening test for celiac disease based on the coating of gold nanoparticles with a peptide sequence derived from gliadin, the protein that triggers celiac disease.

Methods: 20 nm gold nanoparticles were first coated with NeutrAvidin. A long chain Polyethylene glycol (PEG) linker containing Maleimide at the Ω-end and Biotin group at the α-end was used to ensure peptide coating to the gold nanoparticles. Read More

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http://dx.doi.org/10.3748/wjg.v24.i47.5379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305529PMC
December 2018
1 Read

Pancreas Cancer-Associated Weight Loss.

Oncologist 2018 Dec 27. Epub 2018 Dec 27.

Pancreatic Cancer Action Network, Manhattan Beach, California, USA.

Unintentional weight loss in patients with pancreatic cancer is highly prevalent and contributes to low therapeutic tolerance, reduced quality of life, and overall mortality. Weight loss in pancreatic cancer can be due to anorexia, malabsorption, and/or cachexia. Proper supportive care can stabilize or reverse weight loss in patients and improve outcomes. Read More

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2018-0266DOI Listing
December 2018
7 Reads

Inherited selective cobalamin malabsorption in Komondor dogs associated with a CUBN splice site variant.

BMC Vet Res 2018 Dec 27;14(1):418. Epub 2018 Dec 27.

Section of Medical Genetics, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104-6010, USA.

Background: Three Komondor dogs in a small family and 3 sporadic cases exhibited a constellation of signs that included juvenile-onset of failure-to-thrive, inappetence, vomiting and/or diarrhea, and weakness. In each we documented dyshematopoiesis, increased anion gap, methylmalonic acidemia/-uria, and serum cobalamin deficiency. Urine protein electrophoresis demonstrated excretion of cubam ligands. Read More

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http://dx.doi.org/10.1186/s12917-018-1752-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309081PMC
December 2018
3 Reads
1.777 Impact Factor

Molecular and epigenetic regulatory mechanisms of normal stem cell radiosensitivity.

Cell Death Discov 2018 18;4:117. Epub 2018 Dec 18.

1Cancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, Saint Louis, MO 63108 USA.

Ionizing radiation (IR) therapy is a major cancer treatment modality and an indispensable auxiliary treatment for primary and metastatic cancers, but invariably results in debilitating organ dysfunctions. IR-induced depletion of neural stem/progenitor cells in the subgranular zone of the dentate gyrus in the hippocampus where neurogenesis occurs is considered largely responsible for deficiencies such as learning, memory, and spatial information processing in patients subjected to cranial irradiation. Similarly, IR therapy-induced intestinal injuries such as diarrhea and malabsorption are common side effects in patients with gastrointestinal tumors and are believed to be caused by intestinal stem cell drop out. Read More

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http://dx.doi.org/10.1038/s41420-018-0132-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299079PMC
December 2018
1 Read

Systematic review with meta-analysis: the prevalence of bile acid malabsorption and response to colestyramine in patients with chronic watery diarrhoea and previous cholecystectomy.

Aliment Pharmacol Ther 2019 Feb 25;49(3):242-250. Epub 2018 Dec 25.

Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain.

Background: A limited number of small-sized studies suggest that bile acid diarrhoea is frequent in patients with chronic watery diarrhoea and previous cholecystectomy.

Aim: To perform a systematic review and meta-analysis to assess the prevalence of bile acid diarrhoea in patients with chronic watery diarrhoea and previous cholecystectomy, and their response to colestyramine, including a new consecutive series of patients.

Methods: MEDLINE and EMBASE were searched up to January 2018. Read More

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http://dx.doi.org/10.1111/apt.15099DOI Listing
February 2019
3 Reads

Age and recurrent stroke are related to the severity of white matter hyperintensities in lacunar infarction patients with diabetes.

Clin Interv Aging 2018 7;13:2487-2494. Epub 2018 Dec 7.

Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People's Republic of China,

Background And Purpose: White matter hyperintensities (WMH) is identified as a marker of cerebral small vessel diseases and is a major contributor to cognitive impairment, depression, gait disturbance, and urinary incontinence. However, the risk factors for WMH in patients with type 2 diabetes mellitus (T2DM) has not been well explored. Thus, in this study, we aimed to investigate the relationship between the severity of WMH and vascular risk factors in lacunar infarction patients with T2DM. Read More

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https://www.dovepress.com/age-and-recurrent-stroke-are-relat
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http://dx.doi.org/10.2147/CIA.S184463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290865PMC
February 2019
7 Reads

We might have got it wrong: Modern wheat is not more toxic for celiac patients.

Food Chem 2019 Apr 5;278:820-822. Epub 2018 Dec 5.

CQ-VR, Chemistry Research Centre, Chemistry Department, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.

If there is a disease in which many myths are part of the daily lives of both patients and clinicians as well as researchers, this must be celiac disease. Here, we discuss the possibility that modern wheat varieties used by man do not have led to the increased prevalence of celiac disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03088146183209
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http://dx.doi.org/10.1016/j.foodchem.2018.12.003DOI Listing
April 2019
2 Reads

Hydrogen Sulfide Ameliorates Developmental Impairments of Rat Offspring with Prenatal Hyperhomocysteinemia.

Oxid Med Cell Longev 2018 12;2018:2746873. Epub 2018 Nov 12.

Kazan Federal University, Kazan 420008, Russia.

Maternal high levels of the redox active amino acid homocysteine-called hyperhomocysteinemia (hHCY)-can affect the health state of the progeny. The effects of hydrogen sulfide (HS) treatment on rats with maternal hHCY remain unknown. In the present study, we characterized the physical development, reflex ontogeny, locomotion and exploratory activity, muscle strength, motor coordination, and brain redox state of pups with maternal hHCY and tested potential beneficial action of the HS donor-sodium hydrosulfide (NaHS)-on these parameters. Read More

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http://dx.doi.org/10.1155/2018/2746873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276483PMC
January 2019
1 Read

Exocrine pancreatic and enterocyte function in patients with advanced pancreatic cancer.

Clin Nutr 2018 Dec 8. Epub 2018 Dec 8.

Amsterdam UMC, Vrije Universiteit, Department of Nutrition and Dietetics, Amsterdam, The Netherlands. Electronic address:

Background & Aims: Exocrine pancreatic function is affected in patients with locally advanced pancreatic cancer (LAPC), clinically leading to steatorrhea. It is unknown whether maldigestion and malabsorption can also be attributed to impaired intestinal enterocyte function. In this exploratory study enterocyte function was assessed in patients with locally advanced pancreatic cancer, treated with Irreversible Electroporation (IRE). Read More

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http://dx.doi.org/10.1016/j.clnu.2018.12.005DOI Listing
December 2018
1 Read

Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens.

J Pharmacol Sci 2019 Feb 11;139(2):65-71. Epub 2018 Dec 11.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Tacrolimus is one of the most commonly used immunosuppressive agents in animal models of transplantation. However, in these models, oral administration is often problematic due to the lowered compliance associated with highly invasive surgery and due to malabsorption in the intestinal tract. Therefore, we carried out a study to determine the pharmacokinetics of tacrolimus after intramuscular (IM) injection and to determine the optimal IM dosing regimens in primate models. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.05.013DOI Listing
February 2019