2,346 results match your criteria Magyar sebeszet[Journal]


Romics László Alapítvány pályázata.

Authors:

Magy Seb 2018 Dec;71(4):182

Sebészet Petz Aladár Megyei Oktató Kórház 9024 Győr, Vasvári Pál út 2. http://www.mst.hu.

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December 2018

Fluorogenic probes for super-resolution microscopy.

Org Biomol Chem 2018 Dec 12. Epub 2018 Dec 12.

Chemical Biology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok krt. 2, 1117 Budapest, Hungary.

Fluorogenic probes efficiently reduce non-specific background signals, which often results in highly improved signal-to-noise ratios. Although this implies improved resolution, fluorogenic probes in the context of super-resolution microscopy are somewhat overlooked. Several excellent reviews summarize recent developments in SRM techniques, labeling techniques or different aspects of small synthetic fluorophores, however there is no comprehensive review on fluorogenic probes suitable for super-resolution microscopy. Read More

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December 2018

Application of human pluripotent stem cells and pluripotent stem cell-derived cellular models for assessing drug toxicity.

Expert Opin Drug Metab Toxicol 2018 Dec 10. Epub 2018 Dec 10.

a Institute of Enzymology, Research Centre for Natural Sciences , 1117 Magyar tudósok körútja 2. Budapest , Hungary.

Introduction: Human pluripotent stem cells (hPSCs) are capable of differentiating into all types of cells in the body and so provide suitable toxicology screening systems even for hard-to-obtain human tissues. Since hPSCs can also be generated from differentiated cells and current gene editing technologies allow targeted genome modifications, hPSCs can be applied for drug toxicity screening both in normal and disease-specific models. Targeted hPSC differentiation is still a challenge but cardiac, neuronal or liver cells, and complex cellular models are already available for practical applications. Read More

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December 2018

Geometric, elastic and contractile-relaxation changes in coronary arterioles induced by Vitamin D deficiency in normal and hyperandrogenic female rats.

Microvasc Res 2018 Nov 28;122:78-84. Epub 2018 Nov 28.

2nd Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary.

Vitamin D (VitD) hypovitaminosis and androgen excess (AE) are both risk factors for cardiovascular diseases in fertile women. However, the possible early interaction between AE and VitD status is not clear. Our goal was to describe how VitD status influences early changes in the biomechanical reactivity of small coronary arterioles in adult female rats after transdermal testosterone treatment. Read More

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November 2018
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Biochemical and pharmacological investigation of novel nociceptin/OFQ analogues and N/OFQ-RYYRIK hybrid peptides.

Peptides 2018 Dec 1. Epub 2018 Dec 1.

Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, H-6726 Szeged, Temesvári krt. 62., Hungary. Electronic address:

The endogenous ligand nociceptin (N/OFQ) and a positively charged synthetic peptide RYYRIK are both selective for the nociceptin opioid receptor (NOPr). Despite their structural dissimilarity, N/OFQ and RYYRIK compete for the same binding site of NOP receptor possessing full and partial agonistic character, respectively. In the view of the message-address concept, hybrid peptide constructs were probed for the NOP receptor combining different regions of N/OFQ and RYYRIK related peptide sequences. Read More

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December 2018

Pd-Catalyzed microwave-assisted synthesis of phosphonated 13α-estrones as potential OATP2B1, 17β-HSD1 and/or STS inhibitors.

Beilstein J Org Chem 2018 14;14:2838-2845. Epub 2018 Nov 14.

Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.

Novel 2- or 4-phosphonated 13α-estrone derivatives were synthesized via the Hirao reaction. Bromo regioisomers (2- or 4-) of 13α-estrone and its 3-benzyl or 3-methyl ether were reacted with diethyl phosphite or diphenylphosphine oxide using Pd(PPh) as catalyst under microwave irradiation. The influence of the new compounds on the transport function of the organic anion transporting polypeptide OATP2B1 was investigated by measuring Cascade Blue uptake. Read More

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November 2018

Interaction of dequalinium chloride with phosphatidylcholine bilayers: A biophysical study with consequences on the development of lipid-based mitochondrial nanomedicines.

J Colloid Interface Sci 2018 Nov 15;537:704-715. Epub 2018 Nov 15.

Institut Galien Paris-Sud, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 92290 Châtenay-Malabry, France. Electronic address:

Dequalinium (DQ) has been proposed as a mitochondrial targeting ligand for nanomedicines, including liposomes, given the implication of these organelles in many diseases. This original study focuses on the interactions of DQ with phosphatidylcholine bilayers during the formation of liposomes. Firstly, PEGylated liposomes suitable for drug delivery were studied and were found to be more stable when made in water than in phosphate-buffered saline, emphasizing the role of electrostatic interactions between positive charges on DQ and the polar head groups of the lipids. Read More

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November 2018
4 Reads

Effect of Polyelectrolyte Mono- and Bilayer Formation on the Colloidal Stability of Layered Double Hydroxide Nanoparticles.

Nanomaterials (Basel) 2018 Nov 28;8(12). Epub 2018 Nov 28.

MTA-SZTE Lendület Biocolloids Research Group, Department of Physical Chemistry and Materials Science, University of Szeged, H-6720 Szeged, Hungary.

Sequential adsorption of polyelectrolytes on nanoparticles is a popular method to obtain thin films after deposition. However, the effect of polyelectrolyte multilayer formation on the colloidal stability of the nanoparticles has not been studied in detail. In the present work, layered double hydroxides (LDH) were synthesized and interaction with oppositely and like-charged polyelectrolytes was investigated. Read More

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November 2018

Riluzole Attenuates L-DOPA-Induced Abnormal Involuntary Movements Through Decreasing CREB1 Activity: Insights from a Rat Model.

Mol Neurobiol 2018 Nov 27. Epub 2018 Nov 27.

Department of Human Genetics, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

Chronic administration of L-DOPA, the first-line treatment of dystonic symptoms in childhood or in Parkinson's disease, often leads to the development of abnormal involuntary movements (AIMs), which represent an important clinical problem. Although it is known that Riluzole attenuates L-DOPA-induced AIMs, the molecular mechanisms underlying this effect are not understood. Therefore, we studied the behavior and performed RNA sequencing of the striatum in three groups of rats that all received a unilateral lesion with 6-hydroxydopamine in their medial forebrain bundle, followed by the administration of saline, L-DOPA, or L-DOPA combined with Riluzole. Read More

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November 2018

Out-of-position telomeres in meiotic leptotene appear responsible for chiasmate pairing in an inversion heterozygote in wheat (Triticum aestivum L.).

Chromosoma 2018 Nov 27. Epub 2018 Nov 27.

Department of Botany and Plant Sciences, University of California, Riverside, CA, 92521, USA.

Chromosome pairing in meiosis usually starts in the vicinity of the telomere attachment to the nuclear membrane and congregation of telomeres in the leptotene bouquet is believed responsible for bringing homologue pairs together. In a heterozygote for an inversion of a rye (Secale cereale L.) chromosome arm in wheat, a distal segment of the normal homologue is capable of chiasmate pairing with its counterpart in the inverted arm, located near the centromere. Read More

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November 2018
1 Read

[Evaluation of chitosan-based nasal dressing in animal model].

Orv Hetil 2018 Nov;159(47):1981-1987

Klinikai Központ, Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs, Munkácsy M. u. 2., 7621.

Introduction: The usefulness of nasal packing after endoscopic sinus surgery is still debated in the literature.

Aim: Our aim was to evaluate the effects of a new chitosan-based nasal dressing in animal model.

Methods: Standard mucosal damage was caused in both nostrils during endoscope-assisted procedure in ten rabbits. Read More

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November 2018
3 Reads

Left ventricular rotational abnormalities in chloroquine-induced cardiomyopathy (from the MAGYAR-Path Study).

Minerva Cardioangiol 2018 Dec;66(6):786-787

Second Department of Medicine and Cardiology Center, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.

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December 2018

Size-Exclusion Borane Catalyzed Domino 1,3-Allylic/Reductive Ireland-Claisen Rearrangements. Impact of the Electronic and Structural Parameters on the 1,3-Allylic Shift Aptitude.

Chemistry 2018 Nov 22. Epub 2018 Nov 22.

HUNGARY.

The reductive Ireland-Claisen rearrangement via borane mediated hydrosilylation is reported. The method employs borane catalyst with a special structural design and affords access to synthetically relevant product with high diastereoselectivity. Depending on electronic and structural parameter, the reaction can be coupled with a 1,3-allylic shift, thus the valence isomer of the Ireland-Claisen product is formed. Read More

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November 2018
1 Read

Impact of copper and iron binding properties on the anticancer activity of 8-hydroxyquinoline derived Mannich bases.

Dalton Trans 2018 Dec;47(47):17032-17045

Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, H-1117 Budapest, Hungary.

The anticancer activity of 8-hydroxyquinolines relies on complex formation with redox active copper and iron ions. Here we employ UV-visible spectrophotometry and EPR spectroscopy to compare proton dissociation and complex formation processes of the reference compound 8-hydroxyquinoline (Q-1) and three related Mannich bases to reveal possible correlations with biological activity. The studied derivatives harbor a CH2-N moiety at position 7 linked to morpholine (Q-2), piperidine (Q-3), and chlorine and fluorobenzylamino (Q-4) substituents. Read More

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December 2018
6 Reads

Towards a Stochastic Paradigm: From Fuzzy Ensembles to Cellular Functions.

Authors:
Monika Fuxreiter

Molecules 2018 Nov 17;23(11). Epub 2018 Nov 17.

MTA-DE Laboratory of Protein Dynamics, Department of Biochemistry and Molecular Biology, H-4032 Debrecen, Hungary.

The deterministic sequence → structure → function relationship is not applicable to describe how proteins dynamically adapt to different cellular conditions. A stochastic model is required to capture functional promiscuity, redundant sequence motifs, dynamic interactions, or conformational heterogeneity, which facilitate the decision-making in regulatory processes, ranging from enzymes to membraneless cellular compartments. The fuzzy set theory offers a quantitative framework to address these problems. Read More

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November 2018
5 Reads

[Kidney exchange programmes in Europe. What is the status of Hungary? A summary of the first results of the ENCKEP (European Network for Collaboration on Kidney Exchange Programmes) COST Action].

Orv Hetil 2018 Nov;159(46):1905-1912

Sebészeti Intézet, Szervtranszplantációs Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen.

Patients with end-stage renal disease may exchange their willing, but incompatible donors among each other in centrally coordinated kidney exchange programmes. The aim of this writing is to summarise the results of the ENCKEP COST Action, and describe the lessons learned with regard to the plans for the Hungarian kidney exchange programme. The ENCKEP COST Action had several workshops since 2016 September, and its first working group conducted two surveys that they summarised in two handbooks; our description is based on these resources. Read More

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November 2018
2 Reads

[The start of the Hungarian lung transplantation program and the first results].

Orv Hetil 2018 Nov;159(46):1859-1868

Mellkassebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest.

The first lung transplantation in Hungary was performed on 12th of December, 2015. It was a joint effort of the National Institute of Oncology and the Semmelweis University. Hereby we summarise the results and experiences from the first three years. Read More

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November 2018
1 Read

Protective Effect of PACAP on Ischemia/Reperfusion-Induced Kidney Injury of Male and Female Rats: Gender Differences.

J Mol Neurosci 2018 Nov 16. Epub 2018 Nov 16.

Department of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, Szigeti ut 12, Pecs, 7624, Hungary.

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that exerts general cytoprotective effects, including protection in different kidney disorders. The aim of our study was to investigate the ischemia/reperfusion-induced kidney injury of male and female rats to confirm the protective effects of PACAP in the kidney and to reveal possible gender differences.Male and female Wistar rats underwent unilateral renal artery clamping followed by 24-h, 48-h, or 14-day reperfusion. Read More

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November 2018
6 Reads

Blinking Bug Bite.

Clin Pract Cases Emerg Med 2018 Nov 9;2(4):382-383. Epub 2018 Oct 9.

Pulmonary and Critical Care Associates PC, South Bend, Indiana.

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November 2018

High sensitivity proteomics of prostate cancer tissue microarrays to discriminate between healthy and cancerous tissue.

J Proteomics 2018 Nov 12. Epub 2018 Nov 12.

MS Proteomics Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, H-1117 Budapest, Hungary.

Biopsies, in the form of tissue microarrays (TMAs) were studied to identify anomalies indicative of prostate cancer at the proteome level. TMAs offer a valuable source of well-characterized biological material. However, because of the small tissue sample size method development was essential to provide the sensitivity and reliability necessary for the analysis. Read More

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November 2018
4 Reads

Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma.

Sci Transl Med 2018 Nov;10(467)

Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

The diagnostic definition of indeterminate lung nodules as malignant or benign poses a major challenge for clinicians. We discovered a potential marker, the sodium-dependent glucose transporter 2 (SGLT2), whose activity identified metabolically active lung premalignancy and early-stage lung adenocarcinoma (LADC). We found that SGLT2 is expressed early in lung tumorigenesis and is found specifically in premalignant lesions and well-differentiated adenocarcinomas. Read More

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November 2018
7 Reads

Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events in the ODYSSEY OUTCOMES Trial.

J Am Coll Cardiol 2018 Oct 27. Epub 2018 Oct 27.

Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris and Paris Diderot University, Sorbonne Paris Cité, FACT (French Alliance for Cardiovascular Trials), INSERM U1148, Paris, France; National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, London, UK.

Background: The ODYSSEY OUTCOMES trial compared alirocumab with placebo, added to high-intensity or maximum tolerated statin treatment, after acute coronary syndrome (ACS) in 18,924 patients. Alirocumab reduced the first occurrence of the primary composite endpoint and was associated with fewer all-cause deaths.

Objectives: This pre-specified analysis determined the extent to which alirocumab reduced total (first and subsequent) nonfatal cardiovascular events and all-cause deaths in ODYSSEY OUTCOMES. Read More

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October 2018
1 Read

The Melting Diagram of Protein Solutions and Its Thermodynamic Interpretation.

Int J Mol Sci 2018 Nov 12;19(11). Epub 2018 Nov 12.

Institute of Enzymology, Research Centre for Natural Sciences of the HAS, Magyar Tudósok körút. 27, H-1117 Budapest, Hungary.

Here we present a novel method for the characterization of the hydration of protein solutions based on measuring and evaluating two-component wide-line ¹H NMR signals. We also provide a description of key elements of the procedure conceived for the thermodynamic interpretation of such results. These interdependent experimental and theoretical treatments provide direct experimental insight into the potential energy surface of proteins. Read More

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November 2018

Left ventricular rotational mechanics differ between lipedema and lymphedema: Insights from the three-dimensional speckle tracking echocardiographic MAGYAR-path study.

Lymphology 2018 ;51(3):102-108

Department of Dermatology and Allergology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.

The present study aimed to assess LV rotational mechanics by three-dimensional speckle-tracking echocardiography (3DSTE) in lipedema (n=25), lymphedema (n=26) patient groups with age- and gender-matched healthy controls (n=54). 3 lipedema and 4 lymphedema patients were excluded due to insufficient image quality for 3DSTE analysis. LV apical rotation (9. Read More

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January 2018
3 Reads

Correction to: Copper signalling: causes and consequences.

Cell Commun Signal 2018 Nov 12;16(1):80. Epub 2018 Nov 12.

Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary.

Following publication of the original article [1], the authors reported an error in Table 3. The correct version of Table 3 is shown below:The publishers apologise for this error. The original article [1] has been corrected. Read More

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November 2018
2 Reads

The validation of the Hungarian version of the ID-migraine questionnaire.

J Headache Pain 2018 Nov 12;19(1):106. Epub 2018 Nov 12.

Department of Neurology, Semmelweis University, Balassa u. 6, Budapest, 1083, Hungary.

Background: Despite its high prevalence, migraine remains underdiagnosed and undertreated. ID-Migraine is a short, self-administrated questionnaire, originally developed in English by Lipton et al. and later validated in several languages. Read More

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November 2018
4 Reads

The psychological and genetic factors of the addictive behaviors (PGA) study.

Int J Methods Psychiatr Res 2018 Nov 6:e1748. Epub 2018 Nov 6.

Department of Clinical Psychology and Addiction, Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.

Objectives: Most of the addiction studies focus on very specific aspects of addictions, often with contradictory results, and integrated studies are quite rare. Experimental studies comparing underlying mechanisms of addictions and analyzing data from an integrative psychological and genetic perspective are almost nonexistent. The aim of the present paper is to describe the research protocol of the Psychological and Genetic Factors of Addictive Behaviors (PGA) study, which applies an integrative approach to understanding the acquisition, development, and maintenance of addictive behaviors. Read More

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November 2018
9 Reads

Transfer learning improves resting-state functional connectivity pattern analysis using convolutional neural networks.

Gigascience 2018 Dec 1;7(12). Epub 2018 Dec 1.

Brain Imaging Centre, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2., 1117 Budapest, Hungary.

Background: Deep learning is gaining importance in the prediction of cognitive states and brain pathology based on neuroimaging data. Including multiple hidden layers in artificial neural networks enables unprecedented predictive power; however, the proper training of deep neural networks requires thousands of exemplars. Collecting this amount of data is not feasible in typical neuroimaging experiments. Read More

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December 2018
4 Reads

Associations among behavioral inhibition and owner-rated attention, hyperactivity/impulsivity, and personality in the domestic dog (Canis familiaris).

J Comp Psychol 2018 Nov 5. Epub 2018 Nov 5.

Institute of Biology, Department of Ethology, Eötvös Loránd University.

In humans, behavioral disinhibition is associated with attention-deficit/hyperactivity disorder (ADHD). Limitations to rodent models of ADHD-like behaviors/symptoms may be augmented by complementary ones, such as the domestic dog. We examined associations between family dogs' (N = 29; of 14 breeds and 12 mongrels) performance on a self-developed touchscreen behavioral Go/No-Go paradigm and their owner-rated inattention and hyperactivity/impulsivity, accounting for relevant covariates. Read More

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November 2018
1 Read

Chloroplasts preferentially take up ferric-citrate over iron-nicotianamine complexes in Brassica napus.

Planta 2018 Oct 31. Epub 2018 Oct 31.

Department of Plant Physiology and Molecular Plant Biology, Institute of Biology, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/C, 1117, Budapest, Hungary.

Main Conclusion: Fe uptake machinery of chloroplasts prefers to utilise Fe(III)-citrate over Fe-nicotianamine complexes. Iron uptake in chloroplasts is a process of prime importance. Although a few members of their iron transport machinery were identified, the substrate preference of the system is still unknown. Read More

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October 2018

Relationship Between Midface Volume Deficits and the Appearance of Tear Troughs and Nasolabial Folds.

Dermatol Surg 2018 Dec;44(12):1547-1554

Allergan plc, Irvine, California.

Background: Understanding interrelationships among aging facial features is important in facial aesthetics as a global treatment approach becomes standard.

Objective: Examine empirical relationships between midface volume deficit and severity of tear troughs (TTs) and nasolabial folds (NLFs) in women and men of different racial/ethnic groups.

Methods: A web-based study was administered to health panel members (aged 18-75 years). Read More

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December 2018
4 Reads

Seropositivity and Antibody Profiling of Patients Are Dramatically Impacted by the Features of Peptides Used as Immunosorbents: A Lesson from Anti-Citrullinated Protein/Peptide Antibody.

J Immunol 2018 Dec 29;201(11):3211-3217. Epub 2018 Oct 29.

Laboratory of Epithelial Differentiation and Rheumatoid Autoimmunity, UMR 1056 INSERM - Toulouse University, 31059 Toulouse, France.

Quantification of Abs toward a single epitope is critical to understanding immunobiological processes. In autoimmunity, the prognostic value of the serological profiles of patients draws much attention, but the detection of Abs toward a single epitope is not well controlled. Particularly, the rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide Abs (ACPA) are specific to a two-atom change on arginyl residues and are considered a heterogeneous family of Abs. Read More

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December 2018
3 Reads

Physical Background of the Disordered Nature of "Mutual Synergetic Folding" Proteins.

Int J Mol Sci 2018 Oct 26;19(11). Epub 2018 Oct 26.

Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok krt. 2, H-1117 Budapest, Hungary.

Intrinsically disordered proteins (IDPs) lack a well-defined 3D structure. Their disordered nature enables them to interact with several other proteins and to fulfil their vital biological roles, in most cases after coupled folding and binding. In this paper, we analyze IDPs involved in a new mechanism, mutual synergistic folding (MSF). Read More

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October 2018
3 Reads

Co-Evolution of Intrinsically Disordered Proteins with Folded Partners Witnessed by Evolutionary Couplings.

Int J Mol Sci 2018 Oct 25;19(11). Epub 2018 Oct 25.

Research Centre for Natural Sciences of the Hungarian Academy of Sciences, Institute of Enzymology, 1117 Budapest, Hungary.

Although improved strategies for the detection and analysis of evolutionary couplings (ECs) between protein residues already enable the prediction of protein structures and interactions, they are mostly restricted to conserved and well-folded proteins. Whereas intrinsically disordered proteins (IDPs) are central to cellular interaction networks, due to the lack of strict structural constraints, they undergo faster evolutionary changes than folded domains. This makes the reliable identification and alignment of IDP homologs difficult, which led to IDPs being omitted in most large-scale residue co-variation analyses. Read More

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October 2018
2 Reads

Unexpected Sequential NH/HO Solid/Gas Phase Ligand Exchange and Quasi-Intramolecular Self-Protonation Yield [NHCu(OH)MoO], a Photocatalyst Misidentified before as (NH)Cu(MoO).

Inorg Chem 2018 Nov 15;57(21):13679-13692. Epub 2018 Oct 15.

Research Centre for Natural Sciences , Hungarian Academy of Sciences , Magyar Tudósok krt. 2 , Budapest , H-1519 , Hungary.

[NHCu(OH)MoO] as active photocatalyst in the decomposition of Congo Red when irradiated by UV or visible light has been prepared in an unusual ammonia/water ligand exchange reaction of [tetraamminecopper(II)] molybdate, [Cu(NH)]MoO. [Cu(NH)]MoO was subjected to moisture of open air at room temperature. Light blue orthorhombic [Cu(NH)(HO)]MoO was formed in 2 days as a result of an unexpected solid/gas phase ammonia-water ligand exchange reaction. Read More

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November 2018
5 Reads

A highly collateralized thalamic cell type with arousal-predicting activity serves as a key hub for graded state transitions in the forebrain.

Nat Neurosci 2018 Nov 22;21(11):1551-1562. Epub 2018 Oct 22.

Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.

Sleep cycles consist of rapid alterations between arousal states, including transient perturbation of sleep rhythms, microarousals, and full-blown awake states. Here we demonstrate that the calretinin (CR)-containing neurons in the dorsal medial thalamus (DMT) constitute a key diencephalic node that mediates distinct levels of forebrain arousal. Cell-type-specific activation of DMT/CR cells elicited active locomotion lasting for minutes, stereotyped microarousals, or transient disruption of sleep rhythms, depending on the parameters of the stimulation. Read More

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November 2018

Copper signalling: causes and consequences.

Cell Commun Signal 2018 Oct 22;16(1):71. Epub 2018 Oct 22.

Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary.

Copper-containing enzymes perform fundamental functions by activating dioxygen (O) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O transport, metabolism and production of signalling molecules are supported by molecular systems that regulate and preserve tightly-bound static and weakly-bound dynamic cellular copper pools. Disruption of the reducing intracellular environment, characterized by glutathione shortage and ambient Cu(II) abundance drives oxidative stress and interferes with the bidirectional, copper-dependent communication between neurons and astrocytes, eventually leading to various brain disease forms. Read More

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October 2018
4 Reads

Piezosurgical management of sealer extrusion-associated mental nerve anaesthesia: A case report.

Aust Endod J 2018 Oct 18. Epub 2018 Oct 18.

Department of Conservative Dentistry and Periodontology, University of Pécs, Pécs, Hungary.

The present report describes a case where sealer extrusion (Sealapex) occurred during root canal obturation of a left lower second premolar tooth, and the patient experienced sudden pain and followed by complete anaesthesia of the lower lip. After 3 weeks of conservative therapy and an unaltered anaesthesia period, piezosurgical removal of the extruded sealer and root-end resection was performed despite the direct contact with the mental neurovascular bundle. At suture removal, 1 week after surgery, there was no improvement in sensation. Read More

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October 2018
5 Reads

[Paradigm shift in conservative dentistry: the end of the amalgam era].

Orv Hetil 2018 10;159(42):1700-1709

Fogorvostudományi Kar, Fogpótlástani Klinika, Semmelweis Egyetem Budapest, Szentkirályi u. 47., 1088.

Dental amalgam has been used for more than 150 years due to its beneficial mechanical properties and durability in dentistry. In the past and to date, many questions about amalgam restorations have arisen, especially regarding the mercury content, which has been the subject of global disputes. By presenting the past and present of the 'amalgam issue', the aim of our paper is to display the current position of international literature. Read More

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October 2018
1 Read

Effect of Particle Restructuring During Reduction Processes Over Polydopamine-Supported Pd Nanoparticles.

J Nanosci Nanotechnol 2019 Jan;19(1):484-491

Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Magyar tudósok körútja 2, 1117, Hungary.

The effect of catalyst restructuring on the polydopamine-supported Pd catalyzed transfer hydrogenation of ethyl 4-nitrobenzoate and the catalytic hydrogenation of ()-2-methyl-2-butenoic acid is reported. Transmission electron microscopy investigation of different catalyst pre-treatment and reaction conditions revealed high catalytic activity in both reactions unless drastic aggregation of the active metal occurred. In the transfer hydrogenation reaction aggregation was primarily dependent on the H-source used, while in the catalytic hydrogenation additives in combination with the reductive environment led to extensive Pd aggregation and thus decreased catalytic activity. Read More

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January 2019

Genotyping of Riemerella anatipestifer by ERIC-PCR and correlation with serotypes.

Avian Pathol 2018 Oct 17:1-5. Epub 2018 Oct 17.

a Respiratory Bacteriology Research Team, Institute for Veterinary Medical Research , Centre for Agricultural Research, Hungarian Academy of Sciences , Budapest , Hungary.

Riemerella anatipestifer (RA) is a widely distributed bacterial pathogen of birds responsible for remarkable losses to poultry production, especially among waterfowl. We characterized the genomic diversity of 166 field isolates of RA, collected from geese and ducks, using enterobacterial repetitive intergenic consensus (ERIC)-polymerase chain reaction (PCR). The field strains and five reference strains showed 17 distinct patterns consisting of five to 12 bands ranging from approximately 150-1800bp. Read More

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October 2018
1 Read
1.640 Impact Factor

The thiosemicarbazone MeNNMe induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition.

Cell Death Dis 2018 Oct 15;9(11):1052. Epub 2018 Oct 15.

Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090, Vienna, Austria.

Due to their high biological activity, thiosemicarbazones have been developed for treatment of diverse diseases, including cancer, resulting in multiple clinical trials especially of the lead compound Triapine. During the last years, a novel subclass of anticancer thiosemicarbazones has attracted substantial interest based on their enhanced cytotoxic activity. Increasing evidence suggests that the double-dimethylated Triapine derivative MeNNMe differs from Triapine not only in its efficacy but also in its mode of action. Read More

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October 2018
8 Reads

A road map for prioritizing warheads for cysteine targeting covalent inhibitors.

Eur J Med Chem 2018 Dec 6;160:94-107. Epub 2018 Oct 6.

Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok krt 2, H-1117, Budapest, Hungary. Electronic address:

Targeted covalent inhibitors have become an integral part of a number of therapeutic protocols and are the subject of intense research. The mechanism of action of these compounds involves the formation of a covalent bond with protein nucleophiles, mostly cysteines. Given the abundance of cysteines in the proteome, the specificity of the covalent inhibitors is of utmost importance and requires careful optimization of the applied warheads. Read More

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December 2018
8 Reads

Study of PtO/TiO₂ Photocatalysts in the Photocatalytic Reforming of Glycerol: The Role of Co-Catalyst Formation.

Materials (Basel) 2018 Oct 10;11(10). Epub 2018 Oct 10.

Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary.

In this study, relationships between preparation conditions, structure, and activity of Pt-containing TiO₂ photocatalysts in photoinduced reforming of glycerol for H₂ production were explored. Commercial Aerolyst TiO₂ (P25) and homemade TiO₂ prepared by precipitation-aging method were used as semiconductors. Pt co-catalysts were prepared by incipient wetness impregnation from aqueous solution of Pt(NH₃)₄(NO₃)₂ and activated by calcination, high temperature hydrogen, or nitrogen treatments. Read More

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October 2018

Distinguishing Core and Antenna Fucosylated Glycopeptides Based on Low-Energy Tandem Mass Spectra.

Anal Chem 2018 Nov 17;90(21):12776-12782. Epub 2018 Oct 17.

MS Proteomics Research Group, Research Centre for Natural Sciences , Hungarian Academy of Sciences , Magyar Tudósok körútja 2 , H-1117 Budapest , Hungary.

A straightforward approach has been developed to distinguish core and antenna fucosylation in glycopeptides. The method does not require derivatization and can be easily adapted into a proteomics workflow. The key aspect is to use low collision energy collision-induced dissociation (CID) (on a quadrupole time-of-flight type instrument) when only single-step fragmentation processes occur. Read More

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November 2018
4 Reads

[Possibilities for residual hearing preservation with Nucleus CI532 Slim Modiolar electrode array. Case report].

Orv Hetil 2018 10;159(41):1680-1688

Általános Orvostudományi Kar, Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika, Szegedi Tudományegyetem Szeged, Tisza Lajos krt. 111., 6725.

During the rehabilitation of hearing-impaired patients, the preservation of residual acoustic hearing following cochlear implantation by minimizing the implantation trauma allows for improved hearing performance. To achieve this, minimally invasive, soft surgery methods and thinner, atraumatic electrodes were required. In our present study, we reported a case where Cochlear® Nucleus CI532 Slim Modiolar electrode was implanted in a patient with residual hearing. Read More

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October 2018
7 Reads

Effects of sulfide and polysulfides transmitted by direct or signal transduction-mediated activation of TRPA1 channels.

Br J Pharmacol 2018 Oct 6. Epub 2018 Oct 6.

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.

Hydrogen sulfide (H S) is a gaseous mediator in various physiological and pathological processes, including neuroimmune modulation, metabolic pathways, cardiovascular system, tumour growth, inflammation and pain. Now the hydrogen polysulfides (H S ) have been recognised as signalling molecules modulating ion channels, transcription factors and protein kinases. Transient receptor potential (TRP) cation channels can be activated by mechanical, thermal or chemical triggers. Read More

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October 2018
8 Reads

Life beyond the Tanimoto coefficient: similarity measures for interaction fingerprints.

J Cheminform 2018 Oct 4;10(1):48. Epub 2018 Oct 4.

Plasma Chemistry Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok krt. 2, Budapest, 1117, Hungary.

Background: Interaction fingerprints (IFP) have been repeatedly shown to be valuable tools in virtual screening to identify novel hit compounds that can subsequently be optimized to drug candidates. As a complementary method to ligand docking, IFPs can be applied to quantify the similarity of predicted binding poses to a reference binding pose. For this purpose, a large number of similarity metrics can be applied, and various parameters of the IFPs themselves can be customized. Read More

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October 2018
3 Reads

Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial.

Lancet Neurol 2018 Dec 28;17(12):1053-1060. Epub 2018 Sep 28.

Division of Neurology, McMaster University, Hamilton, ON, Canada.

Background: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with aspirin among patients with PFO enrolled in the NAVIGATE ESUS trial. Read More

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December 2018
10 Reads

Effects of side-dominance on knee joint proprioceptive target-matching asymmetries.

Physiol Int 2018 09 1;105(3):257-265. Epub 2018 Oct 1.

1 Pain Clinic , Budapest, Hungary.

Aims: Right- and left-side-dominant individuals reveal target-matching asymmetries between joints of the dominant and non-dominant upper limbs. However, it is unclear if such asymmetries are also present in lower limb's joints. We hypothesized that right-side-dominant participants perform knee joint target-matching tasks more accurately with their non-dominant leg compared to left-side-dominant participants. Read More

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September 2018