799,693 results match your criteria Magnetic Resonance in Chemistry [Journal]


Thalamic Morphometric Changes Induced by First-Person Action Videogame Training.

Eur J Neurosci 2018 Dec 16. Epub 2018 Dec 16.

Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Italy.

Cross-sectional data suggest videogaming as promoting modifications in perceptual and cognitive skills of players, as well as inducing structural brain changes. However, whether such changes are both possible after a systematic gaming exposure, and last beyond the training period, is not known. Here we originally quantified immediate and long-lasting cognitive and morphometric impact of a systematic gaming experience on a first-person shooter (FPS) game. Read More

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December 2018

Cases of prolonged mild disturbance of consciousness and acute encephalopathy.

Pediatr Int 2018 Dec 15. Epub 2018 Dec 15.

Division of Neurology, National Center for Child Health and Development, Tokyo, Japan 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Background: Acute encephalopathy (AE) is defined by the Japanese guidelines as the acute disturbance of consciousness (Glasgow Coma Scale score ≤11) that persists for more than 24 hours. However, we have often encountered cases of prolonged mild disturbance of consciousness (PMDC) with Glasgow Coma Scale scores >11 that do not fit the definition of acute encephalopathy by the guidelines. The reports of these cases have been relatively sparse, and their nosological position, prognosis, and other characteristics remain unknown. Read More

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December 2018

Clinically applicable delineation of the pallidal sensorimotor region in patients with advanced Parkinson's disease: study of probabilistic and deterministic tractography.

Authors:

J Neurosurg 2018 Dec 14:1-12. Epub 2018 Dec 14.

OBJECTIVEDeep brain stimulation (DBS) is an effective procedure in improving motor symptoms for patients with advanced Parkinson's disease (PD) through the use of high-frequency stimulation. Although one of the most commonly used target sites for DBS, sensorimotor regions of the globus pallidus interna (GPi) have yet to be thoroughly described with advanced neuroimaging analysis in vivo for human subjects. Furthermore, many imaging studies to date have been performed in a research setting and bring into question the feasibility of their applications in a clinical setting, such as for surgical planning. Read More

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December 2018

Rituximab in the Treatment of Refractory Anti-HMGCR Immune-mediated Necrotizing Myopathy.

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

From the Department of Internal Medicine and Clinical Immunology and Inflammation-Immunopathology-Biotherapy Department (I2B), Pitié- Salpêtrière University Hospital, AP-HP, East Paris Neuromuscular Diseases Reference Center, Inserm U974, Sorbonne Université, Paris, France; Center of Reference for Neuromuscular Disorders AOC, Department of Neurology, Bordeaux University Hospital, Bordeaux, France; Polyvalent and Oncologic Radiology Department, Musculoskeletal Unit, Pitié-Salpêtrière University Hospital, AP-HP, Paris, France. Dr. Landon-Cardinal is the recipient of Clinical Fellowship awards from the Université de Montréal Rheumatology Program, Abbvie Educational Grant and the Association des médecins rhumatologues du Québec, Visithan-Khy Educational Grant. O. Landon-Cardinal, MD, Myositis post-doctoral Fellowship, Department of Internal Medicine and Clinical Immunology, AP-HP, Hôpital Pitié- Salpêtrière; Y. Allenbach, MD, PhD, Assistant Professor of Medicine, Department of Internal Medicine and Clinical Immunology, AP-HP, Hôpital Pitié-Salpêtrière; A. Soulages, MD, Clinical Associate of Medicine, Center of Reference for Neuromuscular Disorders AOC, Department of Neurology, Bordeaux University Hospital; A. Rigolet, MD, Clinical Associate of Medicine, Department of Internal Medicine and Clinical Immunology, AP-HP, Hôpital Pitié-Salpêtrière; B. Hervier, MD, PhD, Clinical Associate of Medicine, Department of Internal Medicine and Clinical Immunology, AP-HP, Hôpital Pitié-Salpêtrière; N. Champtiaux, MD, PhD, Clinical Associate of Medicine, Department of Internal Medicine and Clinical Immunology, AP-HP, Hôpital Pitié-Salpêtrière; Q. Monzani, MD, Polyvalent and Oncologic Radiology Department, Musculoskeletal Unit, AP-HP, Hôpital Pitié-Salpêtrière; G. Solé, MD, Professor of Medicine, Center of Reference for Neuromuscular Disorders AOC, Department of Neurology, Bordeaux University Hospital; O. Benveniste, MD, PhD, Professor of Medicine, Department of Internal Medicine and Clinical Immunology, AP-HP, Hôpital Pitié-Salpêtrière. Address correspondence to Dr. O. Landon-Cardinal, Department of Internal Medicine, Pitié-Salpêtrière University Hospital, 47-83 Boulevard de l'Hôpital, 75013 Paris, France. E-mail: Accepted for publication September 11, 2018.

Objective: A pathogenic role of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies has been proposed. Our objective was to assess efficacy of rituximab (RTX) in anti-HMGCR immune-mediated necrotizing myopathy.

Methods: All patients who had been treated with RTX were retrospectively reviewed to assess features and outcome. Read More

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December 2018

Value of Color Doppler Ultrasound Assessment of Sacroiliac Joints in Patients with Inflammatory Low Back Pain.

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

From the Rheumatology Unit, Internal Medicine Department, and the Radiology Department, Hospital Italiano de Buenos Aires; University Institute Hospital Italiano de Buenos Aires; Fundación Dr. Pedro M. Catoggio para el Progreso de la Reumatología, Buenos Aires, Argentina. This study was supported by an Investigator Initiated Study Grant from UCB. J.E. Rosa, MD, Rheumatology Unit, Internal Medicine Department, Hospital Italiano de Buenos Aires, and University Institute Hospital Italiano de Buenos Aires; S. Ruta, MD, Rheumatology Unit, Internal Medicine Department, Hospital Italiano de Buenos Aires, and University Institute Hospital Italiano de Buenos Aires; M. Bravo, MD, Rheumatology Unit, Internal Medicine Department, Hospital Italiano de Buenos Aires, and University Institute Hospital Italiano de Buenos Aires; L. Pompermayer, MD, Rheumatology Unit, Internal Medicine Department, Hospital Italiano de Buenos Aires, and University Institute Hospital Italiano de Buenos Aires; J. Marin, MD, Rheumatology Unit, Internal Medicine Department, Hospital Italiano de Buenos Aires, and University Institute Hospital Italiano de Buenos Aires; L. Ferreyra-Garrot, MD, Rheumatology Unit, Internal Medicine Department, Hospital Italiano de Buenos Aires, and University Institute Hospital Italiano de Buenos Aires; R. García-Mónaco, MD, Radiology Department, Hospital Italiano de Buenos Aires; E.R. Soriano, PhD, Rheumatology Unit, Internal Medicine Department, Hospital Italiano de Buenos Aires, and University Institute Hospital Italiano de Buenos Aires, and Fundación Dr. Pedro M. Catoggio para el Progreso de la Reumatología. Address correspondence to Dr. J.E. Rosa, Sección Reumatología, Servicio de Clínica Médica, Hospital Italiano de Buenos Aires, Gascón 450, Capital Federal 1181, Buenos Aires, Argentina. E-mail: Accepted for publication September 10, 2018.

Objective: To evaluate the diagnostic value of color Doppler ultrasound (CDUS) for the detection of sacroiliitis, in patients with inflammatory back pain (IBP).

Methods: Consecutive patients with IBP and suspected axial spondyloarthritis (SpA), but without a definitive diagnosis, were included. Consecutive patients with defined SpA and axial involvement were included as a control group. Read More

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December 2018

Longitudinal Reliability of the OMERACT Thumb Base Osteoarthritis Magnetic Resonance Imaging Scoring System (TOMS).

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

From the Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Paris 6, Sorbonne Universités, GRC-08 (EEMOIS); AP-HP, Department of Rheumatology, Pitié Salpêtrière University Hospital, Paris, France; Spire Sciences Inc., Boca Raton, Florida; Data and Statistical Sciences, and Immunology Development, AbbVie Inc., North Chicago, Illinois; Departments of Radiology and Medicine, University of California at San Francisco, San Francisco, California; AbbVie Inc., Cambridge, Massachusetts, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research, Leeds Biomedical Research Centre, Leeds, UK; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. PGC is supported in part by the UK National Institute for Health Research infrastructure at Leeds. F.P. Kroon, MD, Department of Rheumatology, Leiden University Medical Center; S. van Beest, MD, Department of Rheumatology, Leiden University Medical Center; F. Gandjbakhch, MD, Practicing Rheumatologist, Paris 6, Sorbonne Universités, GRC-08 (EEMOIS), and AP-HP, Department of Rheumatology, Pitié Salpêtrière University Hospital; C.G. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; S. Chen, Data and Statistical Sciences, AbbVie Inc.; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research, Leeds Biomedical Research Centre; I. Eshed, MD, Associate Professor of Radiology, Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University; V. Foltz, MD, Practicing Rheumatologist, Paris 6, Sorbonne Universités, GRC-08 (EEMOIS), and AP-HP, Department of Rheumatology, Pitié Salpêtrière University Hospital; H.K. Genant, MD, FACR, FRCR, Professor Emeritus of Radiology, Medicine and Orthopedics, Departments of Radiology and Medicine, University of California at San Francisco; I.K. Haugen, MD, PhD, Postdoctoral Researcher, Department of Rheumatology, Diakonhjemmet Hospital; J.K. Medema, MS, Senior Project Leader, Immunology Development, AbbVie Inc.; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, and Department of Clinical Medicine, University of Copenhagen; L. Zhang, Data and Statistical Sciences, AbbVie Inc.; M.C. Levesque, MD, PhD, Foundational Immunology Senior Director, AbbVie Inc.; M. Kloppenburg, MD, PhD, Professor of Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center. Address correspondence to Dr. F.P. Kroon, Department of Rheumatology, Leiden University Medical Center, Post Box 9600, 2300 RC Leiden, the Netherlands. E-mail: Accepted for publication November 7, 2018.

Objective: To assess the longitudinal reliability of the Outcome Measures in Rheumatology (OMERACT) Thumb base Osteoarthritis Magnetic resonance imaging (MRI) Scoring system (TOMS).

Methods: Paired MRI of patients with hand osteoarthritis were scored in 2 exercises (6-mo and 2-yr followup) for synovitis, subchondral bone defects (SBD), osteophytes, cartilage assessment, bone marrow lesions (BML), and subluxation. Interreader reliability of delta scores was assessed. Read More

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December 2018

A serine in the first transmembrane domain of the human E3 ubiquitin ligase MARCH9 is critical for down-regulation of its protein substrates.

J Biol Chem 2018 Dec 15. Epub 2018 Dec 15.

Structural Biology, The Walter and Eliza Hall Institute of Medical Research, Australia.

The membrane-associated RING-CH (MARCH) family of membrane-bound E3 ubiquitin ligases regulates the levels of cell-surface membrane proteins, many of which are involved in immune responses. Although their role in ubiquitin-dependent endocytosis and degradation of cell-surface proteins is extensively documented, the features of MARCH proteins and their substrates that drive the molecular recognition events leading to ubiquitin transfer remain poorly defined. In this study, we sought to determine the features of human MARCH9 that are required for regulating the surface levels of its substrate proteins. Read More

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December 2018

Relationship between depressive symptom severity and amygdala volume in a large community-based sample.

Psychiatry Res Neuroimaging 2018 Dec 6;283:77-82. Epub 2018 Dec 6.

Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. MC 8849, Dallas, TX, USA. Electronic address:

Amygdala is an affective processing center that regulates and assigns valence to different emotions and has been implicated in the pathophysiology of mood disorders. This population-based study employed a community sample of 1747 adults to examine relationships between amygdala volume and depressive symptom severity. Neuroimaging data from participants in the Dallas Heart Study were used. Read More

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December 2018

Cabazitaxel and silibinin co-encapsulated cationic liposomes for CD44 targeted delivery: A new insight into nanomedicine based combinational chemotherapy for prostate cancer.

Biomed Pharmacother 2018 Dec 13;110:803-817. Epub 2018 Dec 13.

Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad 500037, India. Electronic address:

Cancer stem cells (CSCs) are the promising targets for cancer chemotherapy that cannot be eliminated by conventional chemotherapy. In this study cationic liposomes of cabazitaxel (CBX) and silibinin (SIL) were prepared with an aim to kill cancer cells and CSCs for prostate cancer. CBX act as cancer cell inhibitor and SIL as CSC inhibitor. Read More

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December 2018

A general strategy to fabricate soft magnetic CuFeO@SiO nanofibrous membranes as efficient and recyclable Fenton-like catalysts.

J Colloid Interface Sci 2018 Dec 8;538:620-629. Epub 2018 Dec 8.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Innovation Center for Textile Science and Technology, Donghua University, Shanghai 200051, China. Electronic address:

Fenton or Fenton-like technique, as one of the advanced oxidation processes, plays a significant role in the removal of non-easily degradable organic pollutants; however, most of such catalysts are fragile with poor structural integrity under large deformation, thereby restricting their wide applications. Herein, soft copper ferrite nanostructures functionalized silica nanofibrous membranes (CuFeO@SNM) were fabricated through a novel strategy with the combination of in-situ dopamine polymerization, ion adsorption, and cohesive precipitation method. Benefiting from the high metallic ion adsorption capacity of polydopamine together with the rapid co-precipitation of adsorbed ions on fiber surface in alkaline solution, the membranes possessed homogenously distributed nanostructured CuFeO, large specific surface area, and high pore volume, which are a benefit for the improvement of Fenton-like catalytic activity towards organic pollutants decomposition. Read More

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December 2018

Adsorptive removal of patulin from apple juice via sulfhydryl-terminated magnetic bead-based separation.

J Hazard Mater 2018 Dec 3;366:413-422. Epub 2018 Dec 3.

Department of Bioengineering, Karamanoğlu Mehmetbey University, Karaman, Turkey.

Patulin is a naturally produced toxin having potential carcinogenic properties. It is mainly produced by species of Penicillium growing on fruits, especially on apples. Detoxification of patulin, therefore, is very important for providing food safety. Read More

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December 2018

Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson's disease.

Neurobiol Aging 2018 Nov 22;75:83-97. Epub 2018 Nov 22.

Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

In Parkinson's disease (PD), iron accumulation in the substantia nigra (SN) exacerbates oxidative stress and α-synuclein aggregation, leading to neuronal death. However, the influence of iron-related nigral degeneration on the subcortical function and global network configuration in PD remains unknown. Ninety PD patients and 38 normal controls underwent clinical assessments and multimodality magnetic resonance imaging scans. Read More

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November 2018

Combination of OPSY and PhD-PHIP results in enhanced sensitivity in PHIP.

J Magn Reson 2018 Dec 7;299:28-32. Epub 2018 Dec 7.

Universidad Nacional de Córdoba, Facultad de Matemática, Atronomía, Física y Computación, Córdoba, Argentina; CONICET, Instituto de Física Enrique Gaviola (IFEG), Córdoba, Argentina.

Despite the large degree of polarization in PHIP experiments compared to the Boltzmann factor, the presence of a large amount of non-reacted molecules with thermal polarization is an important obstacle when dealing with very diluted samples. The feasibility of enhancing both sensitivity and resolution in a single experiment by combining two well established pulse sequences, OPSY and PHD-PHIP is presented. OPSY is used as a block for filtering the signals originated from thermally polarized protons. Read More

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December 2018

Time course of microglia activation and brain and blood cytokine/chemokine levels following chronic ethanol exposure and protracted withdrawal in rats.

Alcohol 2018 Jul 17;76:37-45. Epub 2018 Jul 17.

Department of Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States; Dorris Neuroscience Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States.

Alcohol produces complex effects on the immune system. Moderate alcohol use (1-2 drinks per day) has been shown to produce anti-inflammatory responses in human blood monocytes, whereas, the post mortem brains of severe alcoholics show increased immune gene expression and activated microglial markers. The present study was conducted to evaluate the time course of alcohol effects during exposure and after withdrawal, and to determine the relationship between microglial and cytokine responses in brain and blood. Read More

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Pathological laughter as an early and unusual presenting symptom of petroclival meningioma: A case report and review of literature.

World Neurosurg 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, India.

Background: Pathological laughter is inappropriate, involuntary and unmotivated laughter episodes which may or may not be associated with mirth or amusement. Though associated with many diffuse brain pathologies, its association with intracranial focal mass lesions causing ventrolateral brainstem compression like petroclival meningioma is very rare. The exact pathophysiology of this interesting and unusual clinical symptom is unknown but probably involves disinhibition and release of the so-called coordination center located in the upper brainstem due to compression by the tumor. Read More

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December 2018

Solitary fibrous tumor/hemangiopericytoma of spinal cord: a retrospective single-center study of 16 cases.

World Neurosurg 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Objective: In this study, we retrospectively reviewed our experience in the surgical management of solitary fibrous tumor/hemangiopericytomas (SFT/HPCs) of the spinal cord.

Methods: 16 cases with SFT/HPCs of the spinal cord were enrolled in this study. Data on clinical presentation, radiological findings, histopathological features, surgical treatment, adjuvant therapy, and prognosis were retrospectively reviewed. Read More

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December 2018

Design Strategies for Shape-Controlled Magnetic Iron Oxide Nanoparticles.

Adv Drug Deliv Rev 2018 Dec 13. Epub 2018 Dec 13.

Dept. Energía, Medio Ambiente y Salud, Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, E-28049, Madrid, Spain. Electronic address:

Ferrimagnetic iron oxide nanoparticles (magnetite or maghemite) have been the subject of an intense research, not only for fundamental research but also for their potentiality in a widespread number of practical applications. Most of these studies were focused on nanoparticles with spherical morphology but recently there is an emerging interest on anisometric nanoparticles. This review is focused on the synthesis routes for the production of uniform anisometric magnetite/maghemite nanoparticles with different morphologies like cubes, rods, disks, flowers and many others, such as hollow spheres, worms, stars or tetrapods. Read More

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December 2018

The concentration of dissolved organic matter impacts the metabolic response in Daphnia magna exposed to 17α-ethynylestradiol and perfluorooctane sulfonate.

Ecotoxicol Environ Saf 2018 Dec 13;170:468-478. Epub 2018 Dec 13.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, Canada M5S 3H6; Environmental NMR Centre and Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, Canada M1C 1A4. Electronic address:

The pharmaceutical 17α-ethynylestradiol (EE2) and the industrial chemical perfluorooctane sulfonate (PFOS) are organic contaminants frequently detected in freshwater environments. It is hypothesized that hydrophobic organic contaminants can sorb to dissolved organic matter (DOM) and this may reduce the toxicity of these contaminants by reducing the contaminants' bioavailability. To investigate this hypothesis, H nuclear magnetic resonance (NMR)-based metabolomics was used to determine how the metabolome of Daphnia magna changes when a range of DOM concentrations are added during EE2 and PFOS exposure experiments. Read More

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December 2018

Repolarization of myeloid derived suppressor cells via magnetic nanoparticles to promote radiotherapy for glioma treatment.

Nanomedicine 2018 Dec 13. Epub 2018 Dec 13.

Northwestern University Feinberg School of Medicine, Chicago, IL, United States. Electronic address:

Although radiotherapy has been established as a major therapeutic modality for glioma, radical new avenues are critically needed to prevent inevitable tumor recurrence. Herein, we utilized a magnetic nanoparticle-based platform with cationic polymer modification to promote radiotherapy for glioma treatment. We found that the nanoplatform induced cytotoxicity to glioma cells under radiation as well as promoting significant survival benefits in both immunocompetent and aythmic mice with glioma. Read More

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December 2018

Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI.

Neuroimage 2018 Dec 13. Epub 2018 Dec 13.

F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

The goal of this study was to develop a molecular biomarker for the detection of protein aggregation involved in Alzheimer's disease (AD) by exploiting the features of the water saturation transfer spectrum (Z-spectrum), the CEST signal of which is sensitive to the molecular configuration of proteins. A radial-sampling steady-state sequence based ultrashort echo time (UTE) readout was implemented to image the Z-spectrum in the mouse brain, especially the contributions from mobile proteins at the frequency offsets for the composite protein amide proton (+3.6 ppm) and aliphatic proton (-3. Read More

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December 2018

3D Printing and Heart Failure: The Present and the Future.

JACC Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

Department of Internal Medicine, Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.

Advanced imaging modalities provide essential anatomic and spatial information in patients with complex heart disease. Two-dimensional imaging can be limited in the extent to which true 3-dimensional (3D) relationships are represented. The application of 3D printing technology has increased the creation of physical models that overcomes the limitations of a 2D screen. Read More

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December 2018

Intraductal Papillary Neoplasm of the Bile Duct: Assessment of Invasive Carcinoma and Long-Term Outcomes using MRI.

J Hepatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Pathology, BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Background & Aims: Imaging characteristics for discriminating malignant potential of intraductal papillary neoplasm of the bile duct (IPNB) still remain unclear. This study aimed to define the magnetic resonance (MR) imaging findings that help to differentiate IPNB with an associated invasive carcinoma from IPNB with intraepithelial neoplasia and to investigate their significance with respect to long-term outcomes in patients with surgically resected IPNB.

Methods: This retrospective study included 120 patients with surgically resected IPNB who underwent preoperative MR imaging with MR cholangiography before surgery from January 2008 and December 2017 in two tertiary referral centers. Read More

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December 2018

Direct contrast-enhanced magnetic resonance lymphangiography in the diagnosis of persistent occult chylous effusion leak after thoracic duct embolization.

J Vasc Surg Venous Lymphat Disord 2018 Dec 12. Epub 2018 Dec 12.

Section of Vascular and Interventional Radiology, Department of Radiology, Loma Linda University School of Medicine, Loma Linda, Calif. Electronic address:

Thoracic duct embolization (TDE) is currently the technique of choice for chylothorax refractory to medical management. Diagnosis and treatment of persistent lymphatic leakage after an initially successful TDE are complicated by inadequate imaging to localize the nidus of the lymphatic leak. Traditional imaging modalities including nuclear medicine lymphoscintigraphy, magnetic resonance lymphangiography, and fluoroscopic lymphangiography lack spatial resolution and dynamic physiologic real-time evaluation. Read More

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December 2018

Different patterns of white matter changes after successful surgery of mesial temporal lobe epilepsy.

Neuroimage Clin 2018 Dec 8:101631. Epub 2018 Dec 8.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Objectives: To explore the dynamic changes of white matters following anterior temporal lobectomy (ATL) in mesial temporal lobe epilepsy (MTLE) patients who achieved seizure-free at two-year follow-up.

Methods: Diffusion tensor imaging (DTI) was obtained in ten MTLE patients at five serial time points: before surgery, three months, six months, 12 months and 24 months after surgery, as well as in 11 age- and sex-matched healthy controls at one time point. Regions with significant postoperative fractional anisotropy (FA) changes and their dynamic changes were confirmed by comparing all preoperative and postoperative data using Tract-Based Spatial Statistics (TBSS). Read More

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December 2018

Automated and manual hippocampal segmentation techniques: Comparison of results, reproducibility and clinical applicability.

Neuroimage Clin 2018 Oct 14:101574. Epub 2018 Oct 14.

Department of Neurology, Indiana University, Indianapolis, IN, USA; Department of Radiological Sciences, Indiana University, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA. Electronic address:

Background: Imaging techniques used to measure hippocampal atrophy are key to understanding the clinical progression of Alzheimer's disease (AD). Various semi-automated hippocampal segmentation techniques are available and require human expert input to learn how to accurately segment new data. Our goal was to compare 1) the performance of our automated hippocampal segmentation technique relative to manual segmentations, and 2) the performance of our automated technique when provided with a training set from two different raters. Read More

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October 2018

Blind fMRI Source Unmixing via Higher-Order Tensor Decompositions.

J Neurosci Methods 2018 Dec 13. Epub 2018 Dec 13.

Computer Technology Institute & Press "Diophantus" (CTI), Greece; Dept. of Informatics and Telecommunications, National and Kapodistrian University of Athens, Greece; Chinese University of Hong Kong, Shenzhen, China.

Background: The growing interest in neuroimaging technologies generates a massive amount of biomedical data of high dimensionality. Tensor-based analysis of brain imaging data has been recognized as an effective analysis that exploits its inherent multi-way nature. In particular, the advantages of tensorial over matrix-based methods have previously been demonstrated in the context of functional magnetic resonance imaging (fMRI) source localization. Read More

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December 2018

Preoperative Assessment of the Peroneal Tendons in Lateral Ankle Instability: Examining Clinical Factors, Magnetic Resonance Imaging Sensitivity, and Their Relationship.

J Foot Ankle Surg 2018 Dec 12. Epub 2018 Dec 12.

Assistant Professor, Department of Surgery, Division of Orthopaedics, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

The purpose of our study was to examine the preoperative clinical factors and magnetic resonance imaging (MRI) findings associated with peroneal pathology in chronic lateral ankle instability patients, as well as the clinical factors associated with peroneal lesions being detected on MRI. Peroneal pathology was determined from intraoperative findings. Patients with/without peroneal pathology were compared regarding their preoperative clinical findings. Read More

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December 2018

Spontaneous Left Anterior Descending Coronary Artery Dissection in a Teenager.

JACC Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Milan, Italy; Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.

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December 2018

Cannabis induced increase in striatal glutamate associated with loss of functional corticostriatal connectivity.

Eur Neuropsychopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

Cannabis is the most commonly used illicit drug and is known to alter state of consciousness and impair neurocognitive function. However, the mechanisms underlying these effects have yet to be fully elucidated. Rodent studies suggest that Δ9-tetrahydrocannabinol (THC) activates dopaminergic neurons in the limbic system, subsequently enhancing dopamine, which is implicated in the rewarding effects of cannabis. Read More

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December 2018

In vivo metabotropic glutamate receptor 5 availability-associated functional connectivity alterations in drug-naïve young adults with major depression.

Eur Neuropsychopharmacol 2018 Dec 12. Epub 2018 Dec 12.

Neuroscience Research Institute, Gachon University, Incheon, South Korea.

There has been increasing interest in glutamatergic neurotransmission as a putative underlying mechanism of depressive disorders. We performed [C]ABP688 positron emission tomography (PET) and resting-state functional magnetic resonance imaging (rs-fMRI) in drug-naïve young adult patients with major depression to examine alterations in metabotropic glutamate receptor-5 (mGluR5) availability, and to investigate their functional significance relating to neural systems-level changes in major depression. Sixteen psychotropic drug-naïve patients with major depression without comorbidity (median age: 22. Read More

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December 2018

Cardiac Magnetic Resonance Normal Reference Values of Biventricular Size and Function in Male Athlete's Heart.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.

Objectives: The aim of this meta-analysis was to derive normal reference values of biventricular size and function estimated by cardiac magnetic resonance (CMR) in competitive athletes.

Background: Exercise-induced enlargement of cardiac chambers is commonly observed in competitive athletes. However, ventricular dilatation is also a common phenotypic expression of life-threatening cardiomyopathies. Read More

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December 2018

Understanding the Tides of Myocardial Infarction.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Departments of Medicine and Diagnostic Radiology, McGill University Health Centre, Montreal, Quebec, Canada; Department of Medicine, Heidelberg University, Heidelberg, Germany; Department of Radiology, Université de Montréal, Montreal, Quebec, Canada; Department of Medicine and Radiology, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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December 2018

Prognosticating in Cardiac Amyloidosis: Let Me Count the Ways.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Department of Internal Medicine, Division of Cardiology, Center for Cardiac Amyloidosis, Columbia University Medical Center, New York, New York. Electronic address:

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December 2018

Cardiac Magnetic Resonance Imaging in Athletes: Acquiring the Bigger Picture.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Cardiology Clinical Academic Group, St. George's University of London, London, United Kingdom.

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December 2018

Early Detection of Increased Risk for Atrial Fibrillation Recurrence Based on Intra-Atrial Dyssynchrony.

Authors:
Shelby Kutty

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Helen B. Taussig Heart Center, the Johns Hopkins Hospital and School of Medicine, Baltimore, Maryland. Electronic address:

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December 2018

Radiation therapy after sentinel lymph node biopsy for early stage breast cancer using a magnetic tracer: Results of a single institutional prospective study of tolerance.

Cancer Radiother 2018 Dec 12. Epub 2018 Dec 12.

Department of radiation oncology, institut Curie, 25, rue d'Ulm, 75005 Paris, France.

Purpose: . The aim of the study was, through a single institutional analysis of a large population of breast cancer patients, to assess the feasibility of and the tolerance to radiotherapy after the use of magnetic detection method for sentinel lymph node biopsy.

Material And Methods: The super paramagnetic iron oxide particles database was collected prospectively and identified 520 cases from October 2013 to December 2016 at our institution. Read More

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December 2018

A Case of Multiple Cerebral Infarction Preceding Acute Exacerbation of Idiopathic Thrombocytopenic Purpura.

J Stroke Cerebrovasc Dis 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurology, Yokohama Rosai Hospital, Yokohama, Kanagawa, Japan.

Background: Although it was suggested that idiopathic thromobocytopenic purpura (ITP) can be a paradoxical cause of cerebral infarction, previous reports indicate that cerebral infarction associated with ITP occurs when thrombocytopenia is already evident at the onset of cerebral infarction.

Case Report: We report a case of multiple cerebral infarction that preceded acute exacerbation of ITP. An 80-year-old woman with a history of ITP presented with tetraplegia, and brain magnetic resonance imaging revealed multiple infarction in bilateral cerebral and cerebellar hemispheres. Read More

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December 2018

Magnetic C/C-corrector compensating for the chromatic aberration and the spherical aberration of electron lenses.

Ultramicroscopy 2018 Nov 29. Epub 2018 Nov 29.

CEOS GmbH, Englerstr. 28, D-69126 Heidelberg, Germany. Electronic address:

Aberration correction in transmission electron microscopy has proven feasible and useful over a large range of acceleration voltages. The spherical aberration has been corrected for beam energies from 15 kV [1] up to 1.2 MeV [2] while the correction of the chromatic aberration has been achieved for beam energies ranging from 20 kV[3] up to 300 kV[4]. Read More

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November 2018

Maternal reading fluency is associated with functional connectivity between the child's future reading network and regions related to executive functions and language processing in preschool-age children.

Brain Cogn 2018 Dec 12. Epub 2018 Dec 12.

Reading and Literacy Discovery Center, Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Educational Neuroimaging Center, Faculty of Education in Science and Technology, Technion, Haifa, Israel. Electronic address:

Reading is an acquired skill that relies on cognitive-control and language abilities. Home reading environment has been positively correlated with activation in parietal-temporal-occipital association cortex supporting mental imagery and narrative comprehension during a story-listening task in preschool-age children. However, the degree to which maternal reading ability influences early brain development, specifically neural circuits involved with language and reading, is not well understood. Read More

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December 2018

Surgical validation of functional magnetic resonance urography in the study of ureteropelvic junction obstruction in a pediatric cohort.

J Pediatr Urol 2018 Nov 22. Epub 2018 Nov 22.

Pediatric Surgery Department, IRCCS, Istituto Giannina Gaslini, Largo Gaslini 5, 16147, Genoa, Italy; DINOGMI, University of Genoa, Genoa, Italy. Electronic address:

Introduction: Ureteropelvic junction obstruction (UPJO) is one of the most common urological diseases in children. The etiology can be intrinsic, extrinsic (crossing vessel [CV] or adhesions), or mixed. To date, ultrasonography and scintigraphy are considered gold-standard imaging techniques for the study of UPJO. Read More

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November 2018

Evaluation of a multidisciplinary training program in magnetic resonance imaging of patients with axial spondyloarthritis: PROGRESSES Project.

Radiologia 2018 Dec 12. Epub 2018 Dec 12.

Unidad de Radiodiagnóstico, Hospital Universitario Fundación Alcorcón, Madrid, España.

Objective: To analyze the impact of a multidisciplinary training program in magnetic resonance imaging (MRI) for axial spondyloarthritis in daily clinical practice.

Methods: After two years of training workshops for radiologists and rheumatologists, we designed a survey to assess changes in: 1) communication and collaboration between departments; 2) radiologists' interest and keeping up to date in axial spondyloarthritis and rheumatologists' training in MRI; 3) number of MRI studies done; 4) availability of protocols about technical requirements for studying axial spondyloarthritis by MRI and of standardized reporting templates; 5) evaluation and management of axial spondyloarthritis; 6) areas of improvement.

Results: After 50 workshops, 96 rheumatologists and 51 radiologists completed the survey. Read More

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December 2018

Evaluation of commercial kits for purification of circulating free DNA.

Cancer Genet 2018 Dec 29;228-229:21-27. Epub 2018 Aug 29.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia; The Poche Centre, Melanoma Institute Australia, NSW 2065, Australia. Electronic address:

Analysis of liquid biopsies and the identification of non-invasive biomarkers for the diagnosis and prognosis of solid tumors has grown exponentially over the last few years. This has led to an increasing number of commercial kits optimised for the purification of circulating free (cf) DNA and RNA/miRNA from biofluids such as plasma, serum and urine. To optimise and standardise current practices we sought to evaluate the performance of spin column-based and magnetic bead-based commercial kits. Read More

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December 2018

Magnetic chitosan nanocomposite: Fabrication, properties, and optimization for adsorptive removal of crystal violet from aqueous solutions.

Carbohydr Polym 2019 Feb 19;206:844-853. Epub 2018 Nov 19.

Department of Environmental Health Engineering, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran; Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

Recovery of crystal violet (CV) dye was investigated using magnetic chitosan nano-composites (MCNCs) and the effects of process variables (contact time, initial CV concentration, adsorbent dose, and pH) were optimized through response surface methodology. The reliability of the RSM models (first-order model, first model with interaction, the second-order model, and reduced model) was tested by fitting the data. A comparative analysis of the results derived from the models demonstrated that the reduced model was the best. Read More

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February 2019

β-cyclodextrin based dual-responsive multifunctional nanotheranostics for cancer cell targeting and dual drug delivery.

Carbohydr Polym 2019 Feb 20;206:694-705. Epub 2018 Nov 20.

Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390 002, India. Electronic address:

Multifunctional nanoconjugates possessing an assortment of key functionalities such as magnetism, florescence, cell-targeting, pH and thermo-responsive features were developed for dual drug delivery. The novelty lies in careful conjugation of each of the functionality with magnetic FeO nanoparticles by virtue of urethane linkages instead of silica in a simple one pot synthesis. Further β-cyclodextrin (CD) was utilized to carry hydrophobic as well as hydrophilic drug. Read More

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February 2019

Inverse solubility of chitin/chitosan in aqueous alkali solvents at low temperature.

Carbohydr Polym 2019 Feb 15;206:487-492. Epub 2018 Nov 15.

National Center for Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Science, Wuhan 430071, People's Republic of China. Electronic address:

The low-temperature dissolving mechanism of chitin/chitosan in the alkali (LiOH, NaOH and KOH) aqueous solvents has not been well established yet. As revealed by our XRD and NMR methods, the prepared deacetylated chitins can be categorized as chitin (DA = 0.94-0. Read More

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February 2019

Evolution of flax cell wall ultrastructure and mechanical properties during the retting step.

Carbohydr Polym 2019 Feb 28;206:48-56. Epub 2018 Oct 28.

IRDL, Université Européenne Bretagne, CNRS, UMR 6027, Lorient, France.

Flax retting is a major bioprocess in the cultivation and extraction cycle of flax fibres. The aim of the present study is to improve the understanding of the evolution of fibre properties and ultrastructure caused by this process at the plant cell wall scale. Initially, investigations of the mechanical performances of the flax cell walls by Atomic Force Microscopy (AFM) in Peak Force mode revealed a significant increase (+33%) in the cell wall indentation modulus with retting time. Read More

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February 2019

Structural characterization, antioxidant and antibacterial activities of a novel polysaccharide from Periploca laevigata root barks.

Carbohydr Polym 2019 Feb 13;206:380-388. Epub 2018 Nov 13.

Laboratory of Enzyme Engineering and Microbiology, National School of Engineering of Sfax (ENIS), University of Sfax, P.O. Box 1173, Sfax, 3038, Tunisia.

A novel water-soluble polysaccharide named PLP1 was successfully isolated from root barks of Periploca laevigata by hot water extraction and further purified by DEAE-sepharose chromatography. PLP1 has a relative molar mass of 5.57 10 g/mol determined by Ultra-high performance liquid chromatography (UHPLC). Read More

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February 2019

Morphologic characteristics of severe basilar artery atherosclerotic stenosis on 3D high-resolution MRI.

BMC Neurol 2018 Dec 15;18(1):206. Epub 2018 Dec 15.

Department of Radiology, China-Japan Friendship Hospital, 2 Yinghuayuan Dongjie, Beijing, China.

Background: Two-dimensional high-resolution MRI (2D HRMRI) faces many technical challenges for fully assessing morphologic characteristics of inherent tortuous basilar arteries. Our aim was to investigate remodeling mechanisms and plaque distribution in symptomatic patients with basilar artery stenosis on three-dimensional (3D) HRMRI.

Methods: Forty-six consecutive patients with symptomatic basilar artery atherosclerotic stenosis on MRA (70-99%) were enrolled. Read More

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December 2018

Therapeutic Hypothermia in Brazil: A MultiProfessional National Survey.

Am J Perinatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, Neonatal Division, McGill University Health Center, Montreal, Quebec, Canada.

Objective:  To determine the rate of therapeutic hypothermia (TH) use, current practices, and long-term follow-up.

Study Design:  Prospective cross-sectional national survey with 19 questions related to the assessment of hypoxic-ischemic encephalopathy (HIE) and TH practices. An online questionnaire was made available to health care professionals working in neonatal care in Brazil. Read More

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December 2018
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