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Breast Dis 2022 ;41(1):303-315

Zabol University of Medical Sciences, Zabol, Iran.

Introduction: Breast cancer is the most common cancer in women worldwide. It is responsible for about 23% of cancer in females in both developed and developing countries. This study aimed to compare the diagnostic performance of contrast-enhanced mammography (CEM) and contrast-enhanced magnetic resonance imaging (CEMRI) in preoperative evaluations of breast lesions. Read More

Eur J Radiol 2022 Jun 4;154:110394. Epub 2022 Jun 4.

School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Wuxing Street, Taipei 110, Taiwan.

Purpose: As we have previously demonstrated, breast cancers originating in the major lactiferous ducts and propagating through the process of neoductgenesis are a distinct subtype of invasive breast cancers, although by current practice they are placed within the group termed ductal carcinoma in situ (DCIS) and are consequently underdiagnosed and undertreated. Imaging biomarkers provide a reliable indication of the site of origin of this breast cancer subtype (Ductal Adenocarcinoma of the breast, DAB) and have excellent concordance with long-term patient outcome. In the present paper, the imaging biomarkers of DAB are described in detail to encourage and facilitate its recognition as a distinct, invasive breast cancer subtype. Read More

J Pers Med 2022 May 25;12(6). Epub 2022 May 25.

Radiology Unit, Mater Olbia Hospital (Qatar Foundation Endowment and Policlinico Universitario Agostino Gemelli IRCCS Foundation), Strada Statale 125 Orientale Sarda, 07026 Olbia, Italy.

Invasive lobular carcinoma is the second most common histologic form of breast cancer, representing 5% to 15% of all invasive breast cancers. Due to an insidious proliferative pattern, invasive lobular carcinoma remains clinically and radiologically elusive in many cases. Breast magnetic resonance imaging (MR) is considered the most accurate imaging modality in detecting and staging invasive lobular carcinoma and it is strongly recommended in pre-operative planning for all ILC. Read More

In Vivo 2022 Jul-Aug;36(4):1977-1981

Department of Surgery, Nagoya Tokushukai General Hospital, Kasugai, Japan.

Background/aim: COVID-19 has been a global pandemic for more than 2 years, and vaccination against COVID-19 using an mRNA vaccine is widespread. The COVID-19 vaccination can cause specific side-effects, such as axillary lymph node swelling; therefore, breast oncologists should pay attention to such occurrences. Initially, only two COVID-19 vaccinations were planned; however, in some countries third or fourth vaccines have been administered. Read More

Radiol Case Rep 2022 Sep 15;17(9):2902-2905. Epub 2022 Jun 15.

Integrated Breast Care Centre, All India Institute of Medical Sciences, Rishikesh, 249203, India.

Chest wall lesions can mimic masses on mammograms and can cause diagnostic difficulty in interpretation. Here, we report a case of an axillary and retro-pectoral vascular malformation visualized on mammography in a 67-year-old patient presenting with fullness in the right axilla and right supraclavicular region. Mammography, ultrasonography (US), and computed tomography (CT) angiography of the patient were done to make the final diagnosis. Read More

Ann Surg Oncol 2022 Jun 20. Epub 2022 Jun 20.

Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Background: Determination of implant size is crucial for patients with breast cancer undergoing one-stage breast reconstruction. The purpose of this study is to predict the implant size based on the breast volume measured by mammography (MG) with a fully automated method, and by breast magnetic resonance imaging (MRI) with a semi-automated method, in breast cancer patients with direct-to-implant reconstruction.

Patients And Methods: This retrospective study included 84 patients with breast cancer who underwent direct-to-implant reconstruction after nipple-sparing or skin-sparing mastectomy and preoperative MG and MRI between April 2015 and April 2019. Read More

Biomed Res Int 2022 6;2022:5164970. Epub 2022 Jun 6.

Department of Pharmacy, Faculty of Medical Sciences, Aljanad University for Science and Technology, Taiz, Yemen.

Medical imaging is the process of visual representation of different tissues and organs of the human body to monitor the normal and abnormal anatomy and physiology of the body. There are many medical imaging techniques used for this purpose such as X-ray, computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), digital mammography, and diagnostic sonography. These advanced medical imaging techniques have many applications in the diagnosis of myocardial diseases, cancer of different tissues, neurological disorders, congenital heart disease, abdominal illnesses, complex bone fractures, and other serious medical conditions. Read More

Eur Radiol 2022 May 31. Epub 2022 May 31.

Department of Computed Tomography and Magnetic Resonance, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.

Objectives: To investigate the diagnostic performance of contrast-enhanced mammography (CEM) combined with the Kaiser score (KS) in digital breast tomosynthesis (DBT) BI-RADS 4A lesions to potentially reduce unnecessary breast biopsies.

Methods: This retrospective study evaluated 106 patients with 109 DBT BI-RADS 4A lesions from June 2019 to June 2021. For the absence of enhancement on CEM, the lesions were downgraded to BI-RADS 3. Read More

Breast 2022 Aug 19;64:85-99. Epub 2022 Apr 19.

Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Objectives: Breast cancer screening guidelines could provide valuable tools for clinical decision making by reviewing the available evidence and providing recommendations. Little information is known about how many countries have issued breast cancer screening guidelines and the differences among existing guidelines. We systematically reviewed current guidelines and summarized corresponding recommendations, to provide references for good clinical practice in different countries. Read More

Breast Cancer (Auckl) 2022 16;16:11782234221095897. Epub 2022 May 16.

Department of Radiology, Femme-Laboratório da Mulher, São Paulo, Brazil.

Rationale And Objectives: According to the Breast Imaging and Reporting Data System (BI-RADS), one of the main limitations of MRI is diagnosing the non-mass enhancement (NME). The NME lesion is challenging since it is unique to the MRI lexicon. This study aims to report our experience with NME lesions diagnosed by MRI referred for MRI-guided biopsies and discuss the management and follow-up of these lesions. Read More

Radiol Case Rep 2022 Jul 11;17(7):2492-2500. Epub 2022 May 11.

Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiotherapy, University Hospital of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.

Vascular lesions of the breast comprise a heterogeneous group that includes a variety of benign, atypical, and malignant lesions. These are a diagnostic challenge given variable clinical, radiological and pathological presentation, especially when they are small and asymptomatic. We present 2 cases of these rare lesions of the breast which were occult to mammographics and ultrasound studies. Read More

Radiol Case Rep 2022 Jul 9;17(7):2470-2476. Epub 2022 May 9.

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.

The presence of synchronous dual hematological diseases is an uncommon finding. We report an unusual case of coexistence of primary central nervous system lymphoma and primary breast lymphoma without systemic involvement in an immunocompetent patient. To our knowledge a similar case has not yet been reported in the literature. Read More

Contrast Media Mol Imaging 2022 6;2022:4224701. Epub 2022 Apr 6.

Department of Clinic Imaging, Taian City Central Hospital, Affiliated Hospital of Qingdao University, Taian 271000, China.

Objectives: We aimed to determine the difference between contrast-enhanced spectral mammography (CESM) and contrast-enhanced magnetic resonance imaging (CE-MRI) in detecting multifocal and multicentric breast cancer (MMBC).

Methods: : This study was conducted among breast cancer patients between July 1, 2017, and May 30, 2021. The sensitivity, specificity, and accuracy of CESM and CE-MRI in the diagnosis of MMBC were evaluated with pathological results as the gold standard. Read More

Cancers (Basel) 2022 Apr 25;14(9). Epub 2022 Apr 25.

Struttura Semplice Dipartimentale di Radiodiagnostica Senologica-IRCCS Istituto Tumori Giovanni Paolo II, Via Orazio Flacco 65, 70124 Bari, Italy.

Purpose: To evaluate radiomics features in order to: differentiate malignant versus benign lesions; predict low versus moderate and high grading; identify positive or negative hormone receptors; and discriminate positive versus negative human epidermal growth factor receptor 2 related to breast cancer.

Methods: A total of 182 patients with known breast lesions and that underwent Contrast-Enhanced Mammography were enrolled in this retrospective study. The reference standard was pathology (118 malignant lesions and 64 benign lesions). Read More

Magn Reson Imaging 2022 09 10;91:24-31. Epub 2022 May 10.

German Cancer Research Center, Department of Radiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

Purpose: In fibroglandular breast tissue, conventional dynamic contrast-enhanced MR-mammography is known to be affected by water content changes during the menstrual cycle. Likewise, amide proton transfer (APT) chemical exchange saturation transfer (CEST)-MRI might be inherently prone to the menstrual cycle, as CEST signals are indirectly detected via the water signal. The purpose of this study was to investigate the influence of the menstrual cycle on APT CEST-MRI in fibroglandular breast tissue. Read More

Semin Roentgenol 2022 Apr 31;57(2):160-167. Epub 2021 Dec 31.

Massachusetts General Hospital, Department of Radiology, Boston, MA. Electronic address:

Artificial intelligence (AI) for breast imaging has rapidly moved from the experimental to implementation phase. As of this writing, Food and Drug Administration (FDA)-approved mammographic applications are available for triage, lesion detection and classification, and breast density assessment. For sonography and MRI, FDA-approved applications are available for lesion classification. Read More

Eur Radiol 2022 Apr 28. Epub 2022 Apr 28.

Department of Radiology and Nuclear Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim-University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167, Mannheim, Germany.

Objectives: Abbreviated breast MRI (AB-MRI) was introduced to reduce both examination and image reading times and to improve cost-effectiveness of breast cancer screening. The aim of this model-based economic study was to analyze the cost-effectiveness of full protocol breast MRI (FB-MRI) vs. AB-MRI in screening women with dense breast tissue for breast cancer. Read More

Breast Cancer (Auckl) 2022 19;16:11782234221092155. Epub 2022 Apr 19.

Department of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, Luebeck, Germany.

Background: The impact of certain tumor parameters on the sensitivity of imaging tools is unknown. The purpose was to study the impact of breast cancer histology, tumor grading, single receptor status, and molecular subtype on the sensitivity of contrast-enhanced breast magnetic resonance imaging (CE-BMRI) vs X-ray mammography (XRM) to detect breast cancer.

Materials And Methods: We ran a supplemental analysis of 2 global Phase III studies which recruited patients with histologically proven breast cancers. Read More

Eur J Breast Health 2022 Apr 1;18(2):199-202. Epub 2022 Apr 1.

Department of Radiology, Trakya University Faculty of Medicine, Edirne, Turkey.

Breast cancer is a rare entity in men, accounting for less than 1% of all breast cancers. Contralateral breast cancer diagnosed within 12 months of the prior breast cancer is known as bilateral synchronous breast cancer. Bilateral, synchronous male breast cancer is extremely rare and consequently there are few publications describing imaging findings of synchronous bilateral male breast cancer. Read More

Eur J Breast Health 2022 Apr 1;18(2):172-181. Epub 2022 Apr 1.

Department of Pathology, Tekirdağ Namık Kemal University School of Medicine, Tekirdağ, Turkey.

Objective: We aimed to investigate mammography (MG), ultrasound (US), and magnetic resonance imaging (MRI) findings of papillary breast carcinoma subtypes and to compare the diagnostic features and performance of the imaging method in distinguishing subtypes.

Materials And Methods: Forty-two patients presenting with pathological diagnosis of 45 papillary carcinoma lesions, between 2014 and 2019, were included. Cases were assigned to five subgroups according to the latest World Health Organization (WHO) classification. Read More

Eur J Breast Health 2022 Apr 1;18(2):190-194. Epub 2022 Apr 1.

Department of Radiology, Ege University Faculty of Medicine, İzmir, Turkey.

Vascular tumors are rare in the breasts, and the most common forms include hemangiomas and angiosarcomas. Hemangiomas are rare benign vascular tumors. Most of them are asymptomatic and nonpalpable clinically, and the vast majority of such lesions are detected incidentally by mammography. Read More

Front Immunol 2022 30;13:850240. Epub 2022 Mar 30.

Department of Oncology, Linköping University, Linköping, Sweden.

High mammographic density and exposure to sex steroids are independent risk factors for breast cancer by yet unknown mechanisms. Inflammation is one hallmark of cancer and the tumor necrosis factor family of proteins (TNFSFs) and receptors (TNFRSFs) are key determinants of tissue inflammation. The relationship between TNFSFs/TNFRSFs and breast tissue density or local breast estradiol levels is unknown. Read More

JAMA Netw Open 2022 04 1;5(4):e227234. Epub 2022 Apr 1.

Harvard Medical School, Boston, Massachusetts.

Importance: Increasing use of screening breast magnetic resonance imaging (MRI), including among women at low or average risk of breast cancer, raises concerns about resulting mammary and extramammary cascades (downstream services and new diagnoses) of uncertain value.

Objective: To estimate rates of cascade events (ie, laboratory tests, imaging tests, procedures, visits, hospitalizations, and new diagnoses) and associated spending following screening breast MRI vs mammography among commercially insured US women.

Design, Setting, And Participants: This cohort study used 2016 to 2018 data from the MarketScan research database (IBM Corporation), which includes claims and administrative data from large US employers and commercial payers. Read More

Curr Med Imaging 2022 Apr 11. Epub 2022 Apr 11.

Baskent University Hospital, Department of Radiology.

Objectives Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) has been recognised in the latest years and there is an ongoing extensive research. Although the exact mechanism and cause are still not clear, we now know that the disease is more associated with textured implants. To the best of our knowledge, no previous study investigating the radiological differential of various implants has been conducted. Read More

Cancer Diagn Progn 2022 Jan-Feb;2(1):87-92. Epub 2022 Jan 3.

Radiology Department, Policlinico Campus Bio-Medico di Roma, Rome, Italy.

Background: Secretory and medullary carcinomas of the breast are rare subtypes of infiltrating ductal carcinoma. The different histological behavior of medullary and secretory carcinomas is correlated with different imaging features on mammography, ultrasound, and magnetic resonance imaging.

Case Report: We report the case of a Caucasian woman in which both subtypes of tumors were diagnosed in an 8-year time interval and evaluate, in antithesis, histopathological and imaging aspects of medullary and secretory carcinoma. Read More

Rozhl Chir 2022 ;101(3):138-142

Occult breast cancer is a very rare type of cancer which presents with axillary lymphadenopathy with no visible mass in the breast. Advances in imaging methods (MRI, PET/CT, PET/MRI, etc.) have enabled the detection of a large number of lesions which are not visible using basic imaging methods, such as mammography and ultrasound. Read More

Clin Radiol 2022 Jul 29;77(7):503-513. Epub 2022 Mar 29.

Department of Radiology, Princess Margaret Hospital, 2-10 Princess Margaret Hospital Road, Lai Chi Kok, Kowloon, Hong Kong.

Physiological and pathological processes arising from the breast and anterior chest wall may share similar clinical presentations because of the small volume of male breasts. Therefore, imaging is frequently required to localise and characterise the lesion and guide biopsy when radiological findings are equivocal or suspicious. Mammography or digital breast tomosynthesis (DBT) and ultrasound are the mainstays of breast imaging work-up. Read More

Sci Data 2022 03 30;9(1):122. Epub 2022 Mar 30.

Cairo University, Computers and Artificial Intelligence, Computer Science Department, Cairo, 12613, Egypt.

Contrast-enhanced spectral mammography (CESM) is a relatively recent imaging modality with increased diagnostic accuracy compared to digital mammography (DM). New deep learning (DL) models were developed that have accuracies equal to that of an average radiologist. However, most studies trained the DL models on DM images as no datasets exist for CESM images. Read More

Semin Nucl Med 2022 Mar 23. Epub 2022 Mar 23.

Department of Radiology, Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

This review gives an overview of the current state of deep learning research in breast cancer imaging. Breast imaging plays a major role in detecting breast cancer at an earlier stage, as well as monitoring and evaluating breast cancer during treatment. The most commonly used modalities for breast imaging are digital mammography, digital breast tomosynthesis, ultrasound and magnetic resonance imaging. Read More

Curr Oncol 2022 03 19;29(3):2119-2131. Epub 2022 Mar 19.

Division of Breast Imaging, Department of Diagnostic Imaging, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.

For women with genetic risk of breast cancer, the addition of screening breast MRI to mammography has become a standard. The order and interval of annual imaging can be variable among providers. To evaluate the clinical implications related to the timing, we conducted a chart review on a cohort of women ( = 276) with high-risk (, , , and ) and moderate high-risk ( and ) predisposition to breast cancer in a 48-month follow up. Read More