Search Our Scientific Publications & Authors

Cancer 2021 Jun 22. Epub 2021 Jun 22.

Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Uptake of cancer risk management based on inherited predispositions, which encompasses bilateral mastectomy (BLM), bilateral salpingo-oophorectomy (BSO), and intensified screening, is the primary motivation for cascade testing for hereditary breast and ovarian cancer (HBOC). However, long-term outcome data for cascade testers are lacking.

Methods: Medical records were abstracted for all unaffected women with pathogenic variants in HBOC genes from 2 cancer hospitals (2013-2019) with at least 1 year of follow-up to compare the uptake of surgery and screening between cascade and noncascade testers. Read More

Front Oncol 2021 1;11:646336. Epub 2021 Jun 1.

Department of Radiology, The Third Affiliated Hospital of Zunyi Medical University, The First People's Hospital of Zunyi, Zunyi, China.

Inflammatory myofibroblastic tumor (IMT) is a rare tumor with low-grade malignant risk mainly occurring in soft tissues and lungs, and it is extremely rare in the breast. Meanwhile, imaging findings of the tumor often present with non-specific features that lead to misdiagnosis and delayed treatment. Here, we report a case of inflammatory myofibroblastic tumor in the breast with the imaging findings of mammography, magnetic resonance imaging (MRI), and pathologic findings to improve the understanding of the disease. Read More

Pol J Radiol 2021 10;86:e277-e286. Epub 2021 May 10.

MR Research and Collaborations, Siemens Healthcare Private Limited, Bangalore, India.

Purpose: To evaluate the utility of high-resolution, 3-D diffusion-weighted imaging (DWI) in the detection of breast cancer and to compare the sensitivity, specificity, and area under the curves of DWI and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).

Material And Method: Prospective IEC approved study included 131 breast lesions detected on mammography and breast ultrasound. Cases underwent MRI on a 3 Tesla scanner using a dedicated breast coil. Read More

Clinics (Sao Paulo) 2021 06 14;76:e2980. Epub 2021 Jun 14.

Programa de Pos-Graduacao em Ciencias da Saude, Universidade Federal do Piaui, Teresina, PI, BR.

Cureus 2021 Jun 8;13(6):e15516. Epub 2021 Jun 8.

Department of Radiology, King Abdulaziz University Hospital, Jeddah, SAU.

Background Neoadjuvant chemotherapy (NAC) is an important step in the treatment of various types of breast cancer by downsizing the tumor to make it operable. Determining disease extent after NAC is essential for accurate surgical planning. MRI has been the gold standard for detecting tumors that are usually difficult to detect on ultrasound or mammography. Read More

PLoS One 2021 11;16(6):e0252476. Epub 2021 Jun 11.

Departments of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: To investigate the imaging characteristics of early and late recurrent breast cancer and the detectability of mammography, ultrasonography, and breast magnetic resonance imaging (MRI) in patients who underwent breast-conservation therapy (BCT).

Materials And Methods: Total of 1312 women with 2026 surveillance breast MRI after BCT between January 2014 and September 2018 were studied. Early recurrence was defined as newly diagnosed breast cancer and/or axillary metastasis within 12 months of surgery. Read More

Med Ultrason 2021 Jun 8. Epub 2021 Jun 8.

Department Allgemeine Innere Medizin (DAIM) Kliniken Hirslanden Beau Site, Salem und Permanence, Bern, Switzerland.

A salivary incidentaloma (SI) stands for any focal salivary lesion, independent of size, discovered by any imaging method including ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), multimodal positron emis-sion tomography (PET) combined with CT or MRI, or X-ray imaging, performed for another reason, in the absence of known salivary glands' disease. The article presents a detailed analysis of salivary gland diseases with the emphasis on neoplasms. It describes frequency of SIs found on imaging, their prevalence, epidemiology and clinical significance. Read More

J Surg Case Rep 2021 Jun 4;2021(6):rjab199. Epub 2021 Jun 4.

Department of Breast Oncology, Saitama Medical University International Medical Center, Saitama, Japan.

Granulomatous mastitis is a rare breast disease that is categorized as a benign tumor with chronic inflammation. Since the cause of the chronic inflammation is usually unknown, it is sometimes called idiopathic granulomatous mastitis (IGM). Although imaging modalities, such as ultrasound, magnetic resonance imaging and mammography can detect tumors, they are sometimes unable to differentiate between benign and malignant tumors. Read More

Front Genet 2021 17;12:628136. Epub 2021 May 17.

College of Information Science and Engineering, Xinjiang University, Urumqi, China.

Mastering the molecular mechanism of breast cancer (BC) can provide an in-depth understanding of BC pathology. This study explored existing technologies for diagnosing BC, such as mammography, ultrasound, magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) and summarized the disadvantages of the existing cancer diagnosis. The purpose of this article is to use gene expression profiles of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) to classify BC samples and normal samples. Read More

J Pers Med 2021 May 25;11(6). Epub 2021 May 25.

Radiology Unit, Mater Olbia Hospital (Qatar Foundation Endowment and Policlinico Universitario Agostino Gemelli IRCCS Foundation), 07026 Olbia, Italy.

Axillary lymph node metastases of occult breast cancer (CUPAx) is an unusual condition that represents both a diagnostic and therapeutic challenge. The first steps in the diagnostic work-up of patients with CUPAx are the histological analysis of the lymph node metastasis and the execution of basic breast diagnostic imaging (mammography and ultrasound). In the case of occult breast cancer, breast Magnetic Resonance (MR) must be performed. Read More

Int J Environ Res Public Health 2021 05 21;18(11). Epub 2021 May 21.

Diagnostic Senology Unit, Azienda Ospedaliero-Universitaria Careggi, 50139 Florence, Italy.

Breast cancer (BC) is the cancer with the highest incidence in women in the world. In this last period, the COVID-19 pandemic has caused in many cases a drastic reduction of routine breast imaging activity due to the combination of various factors. The survival of BC is directly proportional to the earliness of diagnosis, and especially during this period, it is at least fundamental to remember that a diagnostic delay of even just three months could affect BC outcomes. Read More

Curr Med Imaging 2021 May 20. Epub 2021 May 20.

Department of Radiology, College of Medicine, Yeungnam University, Daegu, Korea.

Background: Different molecular breast cancer subtypes present different biologic features, treatment options, and clinical prognoses. The breast cancer imaging phenotype may help precisely classify breast cancer in a non-invasive manner.

Objective: To identify the association between the imaging and clinicopathologic features of invasive breast cancer according to the molecular subtype. Read More

Ann Surg Oncol 2021 May 27. Epub 2021 May 27.

Department of Breast Surgery, Rigshospitalet/Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Some subgroups of breast cancer patients receiving neoadjuvant chemotherapy (NACT) show high rates of pathologic complete response (pCR) in the breast, proposing the possibility of omitting surgery. Prediction of pCR is dependent on accurate imaging methods. This study investigated whether magnetic resonance imaging (MRI) is better than ultrasound (US) in predicting pCR in breast cancer patients receiving NACT. Read More

Ann Transl Med 2021 Apr;9(7):610

Division of Pediatric and Adolescent Gynecology, Department of Surgery, Boston Children's Hospital, Boston, MA, USA.

Medical imaging plays an integral role in the preoperative evaluation and postoperative management of transgender and gender diverse (TGD) patients who pursue gender-affirming surgery. Radiology department encounters can be a source of anxiety for patients of any demographic, including TGD patients. Although most imaging modalities are considered "non-invasive", certain imaging procedures and other aspects of the radiology encounter could be considered quite invasive to the TGD patient. Read More

Ann Transl Med 2021 Apr;9(7):609

Department of Radiology, University of California San Francisco, San Francisco, CA, USA.

Gender-affirming surgeries (GS) allow transgender individuals to align their physical sexual characteristics with their gender identity, which can result in profound changes to native anatomy. Medical imaging is a useful tool for evaluation of patients who have undergone or plan to pursue GS. Given the complex nature of some GS, complications may arise. Read More

Am J Clin Oncol 2021 Jul;44(7):331-339

Department of Nuclear Medicine, College of Medicine, Pusan National University.

Objective: This study aimed to compare diagnostic performances of 8 different imaging modalities for preoperative detection of axillary lymph node (LN) metastasis in patients with breast cancer by performing a network meta-analysis (NMA) using direct comparison studies with 2 or more imaging techniques.

Materials And Methods: PubMed, Cochrane, and Embase were searched for the studies evaluating the performances of 8 different imaging modalities for preoperative axillary LN staging in patients with breast cancer. The NMA was performed in patient-based analyses. Read More

Phys Med 2021 Mar 2;83:221-241. Epub 2021 May 2.

Dipartimento di Fisica E.Pancini, Università degli Studi di Napoli Federico II and INFN Napoli, I-80126 Napoli, Italy.

Purpose: To perform a systematic review on the research on the application of artificial intelligence (AI) to imaging published in Italy and identify its fields of application, methods and results.

Materials And Methods: A Pubmed search was conducted using terms Artificial Intelligence, Machine Learning, Deep learning, imaging, and Italy as affiliation, excluding reviews and papers outside time interval 2015-2020. In a second phase, participants of the working group AI4MP on Artificial Intelligence of the Italian Association of Physics in Medicine (AIFM) searched for papers on AI in imaging. Read More

Breast Dis 2021 Apr 22. Epub 2021 Apr 22.

Biostatistician and Research Consultant, Buderer Drug Co, Perrysburg, OH, USA.

Background: Of the most common imaging modalities for breast cancer diagnosis - mammogram (MAM), ultrasound (US), magnetic resonance imaging (MRI) - it has not been well established which of these most accurately corresponds to the histological tumor size.

Objective: To determine which imaging modality (MAM, US, MRI) is most accurate for determining the histological tumor size of breast lesions.

Methods: A retrospective study of 76 breast cancers found in 73 female patients who received MAM, US, and/or MRI was performed. Read More

J Breast Cancer 2021 Apr;24(2):218-228

Department of Radiology, Seoul National University Hospital, Seoul, Korea.

Purpose: Interest in unenhanced magnetic resonance imaging (MRI) screening for breast cancer is growing due to concerns about gadolinium deposition in the brain and the high cost of contrast-enhanced MRI. The purpose of this report is to describe the protocol of the Diffusion-Weighted Magnetic Resonance Imaging Screening Trial (DWIST), which is a prospective, multicenter, intraindividual comparative cohort study designed to compare the performance of mammography, ultrasonography, dynamic contrast-enhanced (DCE) MRI, and diffusion-weighted (DW) MRI screening in women at high risk of developing breast cancer.

Methods: A total of 890 women with mutation or family history of breast cancer and lifetime risk ≥ 20% are enrolled. Read More

Lab Anim 2021 Apr 22:236772211009074. Epub 2021 Apr 22.

Bracco Imaging, Italy.

Breast cancer is the most common cancer among women worldwide. For high-risk women, contrast enhanced (CE)-magnetic resonance imaging (MRI) is recommended as supplemental screening together with mammography. The development of new MRI contrast agents is an active field of research, which requires efficacy tests on appropriate preclinical pathological models. Read More

Surg Oncol 2021 Mar 31;38:101552. Epub 2021 Mar 31.

Department of Oncology, Turku University Hospital, Finland; University of Turku, Turku, Finland; Finnish Nuclear and Radiation Safety, Helsinki, Finland.

Background: International guidelines do not recommend magnetic resonance imaging (MRI) for all breast cancer patients at primary diagnostics. This study aimed to understand which patient or tumor characteristics are associated with the use of MRI. The role of MRI among other preoperative imaging methods in clinically node negative breast cancer was studied. Read More

Cureus 2021 Mar 12;13(3):e13854. Epub 2021 Mar 12.

Cardiology, Rush University Medical Center, Chicago, USA.

Breast cancer is the most common malignancy affecting women worldwide, and early diagnosis of breast cancer is the key to its successful and effective treatment. Traditional imaging techniques such as mammography and ultrasound are used to detect and configure breast abnormalities; unfortunately, these modalities have low sensitivity and specificity, particularly in young patients with dense breast tissue, breast implants, or post-surgical scar/architecture distortions. Therefore, breast magnetic resonance imaging (MRI) has been superior in the characterization and detection of breast cancer, especially that with invasive features. Read More

Korean J Radiol 2021 Jun 1;22(6):867-879. Epub 2021 Apr 1.

Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.

Objective: To compare the screening performance of diffusion-weighted (DW) MRI and combined mammography and ultrasound (US) in detecting clinically occult contralateral breast cancer in women with newly diagnosed breast cancer.

Materials And Methods: Between January 2017 and July 2018, 1148 women (mean age ± standard deviation, 53.2 ± 10. Read More

Radiol Bras 2021 Mar-Apr;54(2):83-86

Hospital Felício Rocho - Radiologia, Belo Horizonte, MG, Brazil.

Objective: To describe the indications for breast magnetic resonance imaging (MRI) at a referral center for breast cancer in Brazil.

Materials And Methods: This was a retrospective study in which we reviewed the clinical records, including physician requests and patient questionnaires, of women who underwent breast MRI between 2014 and 2018 at a referral center for the diagnosis and treatment of breast cancer in the city of Belo Horizonte, Brazil.

Results: The most common indication for breast MRI was as a complement to mammography/ultrasonography (in 43. Read More

Virchows Arch 2021 Apr 13. Epub 2021 Apr 13.

Pathology & Cytology Dalarna, Region Dalarna, Falun, Sweden.

Granulomatous mastitis is a rare inflammatory disease of varying etiology. Tuberculosis and cystic neutrophilic granulomatous mastitis caused by Corynebacterium are the best-established infectious examples. Despite the increasing incidence of Rickettsia-related diseases worldwide, granulomatous inflammation of breast parenchyma caused by Rickettsia has not yet been reported. Read More

Eur Radiol 2021 Apr 13. Epub 2021 Apr 13.

Department of Radiology, Institut Bergonié, Comprehensive Cancer Centre, F-33076, Bordeaux, France.

Objectives: To evaluate the diagnostic accuracy of breast MRI in identifying lesions requiring excision for patients with suspicious nipple discharge but normal mammograms and ultrasounds.

Methods: Between September 2013 and May 2019, 106 female participants (mean age 57.9 years) were consecutively included in this prospective multicenter study; 102 were retained for analysis. Read More

Clin Breast Cancer 2021 Mar 16. Epub 2021 Mar 16.

Medical Image Optimisation and Perception Group, Discipline of Medical Imaging Science, Faculty of Medicine and Health, The University of Sydney, Australia; Orange Radiology, Laboratories and Research Centre, Calabar, Nigeria.

Purpose: To compare the diagnostic performance of mammography (MG) alone versus MG combined with adjunctive imaging modalities, including handheld ultrasound (HHUS), automated breast ultrasound (ABUS), digital breast tomosynthesis (DBT), contrast-enhanced mammography (CEM), and magnetic resonance imaging (MRI) in women with non-dense and dense breasts.

Patients And Methods: Medline, Embase, PubMed, CINAHL, Scopus, and the Web of Science databases were searched up to October 2019. Quality assessment was performed using QUADAS-2. Read More

Acad Radiol 2021 Apr 9. Epub 2021 Apr 9.

Division of Breast Imaging, Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 USA. Electronic address:

Rationale And Objectives: Our purpose is to understand patient preferences towards contrast-enhanced imaging such as CEM or MRI for breast cancer screening.

Methods And Materials: An anonymous survey was offered to all patients having screening mammography at a single academic institution from December 27 th 2019 to March 6 th 2020. Survey questions related to: (1) patients' background experiences (2) patients' concern for aspects of MRI and CEM measured using a 5-point Likert scale, and (3) financial considerations. Read More

Int J Cancer 2021 Apr 12. Epub 2021 Apr 12.

Division of Health Economics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

To analyse published evidence on the economic evaluation of risk-based screening (RBS), a full systematic literature review was conducted. After a quality appraisal, we compared the cost-effectiveness of risk-based strategies (low-risk, medium-risk and high-risk) with no screening and age-based screening. Studies were also analysed for modelling, risk stratification methods, input parameters, data sources and harms and benefits. Read More

Hered Cancer Clin Pract 2021 Apr 9;19(1):24. Epub 2021 Apr 9.

Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia.

Background: This nationwide study assessed the impact of nationally agreed cancer genetics guidelines on use of BRCA1/2 germline testing, risk management advice given by health professionals to women with pathogenic BRCA1/2 variants and uptake of such advice by patients.

Methods: Clinic files of 883 women who had initial proband screens for BRCA1/2 pathogenic variants at 12 familial cancer clinics between July 2008-July 2009 (i.e. Read More