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Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):330-336. Epub 2018 Dec 12.

Magnetic resonance imaging revealed spinal cord compression due to intervertebral disc herniation of Hansen type I and II in the thoracolumbar vertebral column in two middle-aged coatis () with chronic progressive paraparesis. Surgical treatment included hemilaminectomy and partial corpectomy in one and dorsal laminectomy in the other coati. Both coatis recovered well after surgery. Read More

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):323-329. Epub 2018 Dec 12.

A 2-year-old male neutered mixed breed dog with a body weight of 30 kg was presented for evaluation of a soft subcutaneous mass on the dorsal midline at the level of the caudal thoracic spine. A further clinical sign was intermittent pain on palpation of the area of the subcutaneous mass. The owner also described a prolonged phase of urination with repeated interruption and re-initiation of voiding. Read More

J Crohns Colitis 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, Akershus University Hospital, Lørenskog, Norway.

Background: Crohns disease (CD) is a chronic inflammation in the gut that often progresses to fibrosis. Magnetic Resonance Enterography (MRE) is an important diagnostic tool in evaluating CD. We aimed to assess the prevalence of inflammation and stricturing disease in patients with long-term CD and investigate associations with clinical factors. Read More

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurological Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Few studies have assessed the prognostic importance of preoperative magnetic resonance imaging (MRI) scan findings in patients undergoing en bloc resection of sacral chordomas.

Objective: To (1) report in-depth imaging characteristics of sacral chordomas, (2) describe the patterns of local and distant recurrence, and (3) determine imaging predictors of overall survival (OS) and local recurrence (LR).

Methods: This retrospective case series was obtained from a prospectively maintained spine database from 1995 to 2016. Read More

Cereb Cortex 2018 Dec 12. Epub 2018 Dec 12.

Department of Biomedical Engineering, Johns Hopkins School of Medicine, 773 North Broadway, Baltimore, MD, USA.

The perceived effort level of an action shapes everyday decisions. Despite the importance of these perceptions for decision-making, the behavioral and neural representations of the subjective cost of effort are not well understood. While a number of studies have implicated anterior cingulate cortex (ACC) in decisions about effort/reward trade-offs, none have experimentally isolated effort valuation from reward and choice difficulty, a function that is commonly ascribed to this region. Read More

Cereb Cortex 2018 Dec 12. Epub 2018 Dec 12.

Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, GA, USA.

The human cerebral cortex is highly folded into diverse gyri and sulci. Accumulating evidences suggest that gyri and sulci exhibit anatomical, morphological, and connectional differences. Inspired by these evidences, we performed a series of experiments to explore the frequency-specific differences between gyral and sulcal neural activities from resting-state and task-based functional magnetic resonance imaging (fMRI) data. Read More

Am J Clin Nutr 2018 Dec;108(6):1264-1274

Wageningen University, Division of Human Nutrition, Wageningen, The Netherlands.

Background: Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions.

Objective: The aim of this study was to investigate the potential benefits of WGW consumption compared with RW consumption on liver health and associated parameters. Read More

Dig Surg 2018 Dec 12:1-8. Epub 2018 Dec 12.

Department of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, Verona,

Background: The prevalence of symptoms in pancreatic cystic neoplasms (PCNs) is mainly based on retrospective surgical series. The aim of this study is to describe the actual prevalence of symptoms in PCNs under surveillance.

Methods: Patients with PCNs under surveillance observed from 2015 to 2017 were submitted to magnetic resonance imaging (MRI) and a specific interview. Read More

Phys Med Biol 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiation Oncology, University of Texas Southwestern Medical Centre, Dallas, TX 75235, Dallas, Texas, 75205, UNITED STATES.

The aim of this work is to develop a novel recursive ensemble OARs segmentation (REOS) framework for accurate organs-at-risk (OARs) automatic segmentation. The REOS recursively segment individual OARs by ensembling images features extracted from an organ localization module and a contour detection module. Both modules are based on a 3D U-Net architecture. Read More

Ear Nose Throat J 2018 Dec;97(12):E28-E30

Department of Otolaryngology-Head and Neck Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.

Extra-abdominal fibromatosis (EAF) is a rare, locally aggressive tumor that originates in fascial structures. It accounts for less than 0.3% of all tumors diagnosed. Read More

Orthopedics 2018 Dec 11:1-3. Epub 2018 Dec 11.

Femoral nerve palsy with concomitant patellar dislocation is a rare clinical entity that has not previously been well documented. The authors present the case of a 16-year-old female ballet dancer who sustained a patellar dislocation with concomitant femoral nerve palsy. She experienced muscle weakness after the initial injury and developed neuropathic symptoms through the anterior left thigh. Read More

PLoS One 2018 12;13(12):e0208699. Epub 2018 Dec 12.

Department of Pediatric Oncology and Hematology, Oslo University Hospital, Oslo, Norway.

Genome-wide DNA methylation studies are becoming increasingly important in unraveling the epigenetic basis of cell biology, aging and human conditions. The aim of the present study was to explore whether different methods for extracting DNA from whole blood can affect DNA methylation outcome, potentially confounding DNA methylation studies. DNA was isolated from healthy blood donors (n = 10) using three different extraction methods (i. Read More

PLoS One 2018 12;13(12):e0203514. Epub 2018 Dec 12.

Division of Cardiology, Institute for Cardiology and Cardiac Surgery, NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, United States of America.

Background/objectives: Previous studies have demonstrated that in acute coronary syndrome (ACS), plaque destabilization and vessel inflammation, represented by vessel edema, often occur simultaneously in multiple coronaries, as well as extend to the cerebrovascular system. Our aim was to determine whether the inflammatory vascular processes occurring within the coronaries during ACS extend simultaneously to the descending aorta.

Methods: We prospectively enrolled 111 patients (56 ACS patients and 55 non-ACS patients with known coronary artery disease) to undergo cardiac magnetic resonance of the thoracic aortic wall at presentation and at three-month follow-up. Read More

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Headquarters Joint Force Command (HQ JFC) of the North Atlantic Treaty Organization (NATO), Lago Patria, Giugliano in Campania (NA), Italy.

Study Design: Cross-sectional, retrospective, magnetic resonance (MR) imaging study, performed during cadets' selection procedures of the Italian Air Force Academy.

Objective: To assess the prevalence of spinal MR imaging findings in asymptomatic young adults (18-22 yrs) candidate to Air Force Flight.

Summary Of Background Data: Spinal MR imaging findings are frequently detected in asymptomatic subjects. Read More

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Children's Orthopaedic Center, Children's Hospital Los Angeles.

Study Design: Diagnostic accuracy.

Objective: The purpose of this study was to determine if neural axis abnormalities in early onset scoliosis (EOS) patients can be reliably detected with limited magnetic resonance imaging (MRI) sequences (sagittal T1, sagittal T2).

Summary Of Background Data: MRI's are often performed in EOS patients as studies have shown there are neural axis abnormalities in up to 40% of this population. Read More

Nurs Res 2018 Dec 12. Epub 2018 Dec 12.

Edward J. and Louise Mellen Professor of Nursing, Case Western Reserve University, Cleveland, OH Marvin E. and Ruth Durr Denekas Professor of Nursing, Case Western Reserve University, Cleveland, OH Associate Professor, Case Western Reserve University, Cleveland, OH PhD Student, Case Western Reserve University, Cleveland, OH Professor, Kent State University, Kent, OH Assistant Professor, Case Western Reserve University, Cleveland, OH Assistant Professor, Chief Diversity Officer, The Ohio State University, Columbus, OH Associate Professor, Case Western Reserve University, Cleveland, OH Associate Professor, Case Western Reserve University, Cleveland, OH.

Background: Although many of the proposed mediating processes of self-management interventions are operationally defined as cognitive processes (e.g., acquiring and using information, self-efficacy, motivation, decision-making), little is known about their underlying brain mechanisms. Read More

JBJS Case Connect 2018 Dec 12. Epub 2018 Dec 12.

Miraidaira Orthopaedic Clinic, Tsukubamirai, Japan.

Case: A 19-year-old college baseball outfielder presented with a 3-month history of right shoulder pain. Radiographs, computed tomography, and magnetic resonance imaging showed a large osteochondral defect at the posterosuperior aspect of the glenoid. Arthroscopic evaluation identified an unstable fragment that was partially attached. Read More

Inorg Chem 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry & Materials Science , Northwest University , Xi'an 710127 , Shaanxi , P. R. China.

Two series of new lanthanide complexes, {[Ln(L)(HO)]·DMA·4HO} (1-Ln, Ln = Tb, Gd, and Dy) and {[La(L)]·4HO} (2-La), were prepared successfully by Ln ions and a N-heterocyclic dicarboxylic (2-pyrimidin-5-yl)terephthalic acid (HL) ligand. The four complexes are three-dimensional (3D) microporous frameworks with different secondary building units (SBUs) and exposed Lewis base active sites. Topology analyses reveal that 1-Ln are the binodal (3,8)-connected tfz-d (4)(4·6·8) nets and 2-La is a binodal (2,12)-connected (4)(4·8·12) net. Read More

Biomacromolecules 2018 Dec 12. Epub 2018 Dec 12.

Cellulose nanofiber films (CNFF), were treated via a welding process using ionic liquids (ILs). Acid-base conjugated ILs derived from 1,5-diazabicyclo[4.3. Read More

ACS Nano 2018 Dec 12. Epub 2018 Dec 12.

Catalytic deoxyribozyme has great potential for gene regulation, but poor efficiency of the cleavage of mRNA and lack of versatile DNAzyme vehicles remain big challenges for potent gene therapy. By rational designing a diverse vehicle of polydopamine-Mn2+ nanoparticles (MnPDA), we demonstrate that MnPDA has integrated functions as an effective DNAzyme delivery vector, self-generation source of DNAzyme cofactor for catalytic mRNA cleavage, inherent therapeutic photothermal agent, as well as contrast agents for photoacoustic and magnetic resonance imaging. Specifically, the DNAzyme-MnPDA nanosystem protects catalytic deoxyribozyme from degradation and enhances cellular uptake efficiency. Read More

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

In order to develop a novel kind of antibacterial Cu-containing TiN film with good corrosion resistance, impressive mechanical properties and low cytotoxicity, three differently designed multilayer films of TiCu/TiCuN multilayer (M1, M2, M3) were deposited on the surface of 316L stainless steel surface using the axial magnetic field-enhanced arc ion plating (AMFE-ARP) method, in which the interlayer of TiCu was firstly introduced for Cu-containing TiN film in order to improve comprehensive properties especially corrosion resistance of film. The performance of the TiCu/TiCuN multilayer films were compared with that of the two single layers, TiN and TiCuN, which were deposited by the same method and the same total deposition time. The results indicated that the TiCu/TiCuN multilayer film of M2 revealed the best comprehensive corrosion resistance with low electric current values, high pitting potential and high polarization resistance due to the proper thickness of TiCu interlayers and more number of TiCu/TiCuN bilayers. Read More

Dalton Trans 2018 Dec 12. Epub 2018 Dec 12.

Departament de Química Inorgànica i Orgànica, Secció Inorgànica and Institute of Nanoscience (IN2UB) and Nanotechnology, Universitat de Barcelona, Marti i Franques 1-11, Barcelona-08028, Spain.

Employing the chiral bi-compartmental Schiff-base ligand H2L obtained from the condensation of (RR) or (SS)-1,2-diphenyl-ethylenediamine and o-vanillin, we report the structural characterization of the discrete dinuclear pairs of enantiomers [NiIIEuIII] 1RR, 1SS and [ZnIIEuIII] 2RR, 2SS and the magnetic properties for the series of complexes [NiIILnIII], Ln = Ce, 3RR; Nd, 4RR; Dy, 5RR; Er, 6RR, Yb, 7SS and [ZnIILnIII], Ln = Ce, 8RR; Nd, 9RR; Dy, 10SS; Er, 11SS and Yb, 12RR in which MII is diamagnetic and LnIII is a Kramers lanthanide. Single crystal X-ray diffraction shows that relevant changes in the [ZnIILnIII] structures are produced after a period in open air (2RRb, 2RRc), evidencing that the lability of the ligands bonded to ZnII can modify the structures that will be correlated to the experimental measurements. The dynamic magnetic measurements showed that the [NiIILnIII] and [ZnIILnIII] derivatives exhibit different behaviors in the relaxation of magnetization especially for oblate and prolate LnIII cations. Read More

Phys Chem Chem Phys 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, Assam, India. and Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati-781039, Assam, India.

We report that the Z-type binding rather than X-type binding was favored when 8-hydroxyquinoline (HQ) reacted with presynthesized ZnS quantum dots (Qdots) to form surface zinc quinolinate complexes having a preferred stoichiometry of 1 : 2 (surface Zn2+ : HQ). Importantly, the higher solubility in polar solvents and high desorption coefficient (following Langmuir binding isotherm) of HQ-treated ZnS Qdot in DMSO solvent compared with those in methanol clearly indicated the favorable Z-type binding of HQ and thus the formation of surface octahedral ZnQ2 complex. Furthermore, the characteristics peaks in the 1H-nuclear magnetic resonance (NMR) spectrum of the desorbed species and the ligand density calculation of the surface complex (formed due to the reaction between HQ and ZnS Qdot) supported the octahedral ZnQ2 complex formation. Read More

J Cereb Blood Flow Metab 2018 Dec 12:271678X18818291. Epub 2018 Dec 12.

1 Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark.

The aging brain is associated with atrophy along with functional and metabolic changes. In this study, we examined age-related changes in resting brain functions and the vulnerability of brain physiology to hypoxic exposure in humans in vivo. Brain functions were examined in 81 healthy humans (aged 18-62 years) by acquisitions of gray and white matter volumes, cerebral blood flow, cerebral oxygen consumption, and concentrations of lactate, N-acetylaspartate, and glutamate+glutamine using magnetic resonance imaging and spectroscopy. Read More

AJR Am J Roentgenol 2018 Dec 12:W1-W7. Epub 2018 Dec 12.

1 Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.

Objective: The purpose of this study was to evaluate four previously validated MRI activity scoring systems for diagnosis and grading of Crohn disease (CD) in the terminal ileum against an endoscopic and histopathologic reference standard.

Subjects And Methods: Ethics approval and written informed consent were obtained. Subjects with known or suspected CD were prospectively recruited between December 2011 and August 2014. Read More

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e464s. Epub 2018 Dec 10.

Grupo de Uro-Oncologia, Departamento de Urologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Objective: Bipolar disorder (BD) is highly heritable. The present study aimed at identifying brain morphometric features that could represent markers of BD vulnerability in non-bipolar relatives of bipolar patients.

Methods: In the present study, structural magnetic resonance imaging brain scans were acquired from a total of 93 subjects, including 31 patients with BD, 31 non-bipolar relatives of BD patients, and 31 healthy controls. Read More

Chin Med J (Engl) 2018 Dec;131(24):2960-2967

Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.

Background: Nowadays, the anterior cruciate ligament (ACL) injury has been one of the most common diseases of the knee joint. The relationships between the ACL injury and the anatomical structures are still controversial. This study aimed to identify the anatomical risk factors of ACL injury by magnetic resonance imaging (MRI) of the knee. Read More

Chin Med J (Engl) 2018 Dec;131(24):2930-2937

Department of Radiology, Beijing Youan Hospital Affiliated to Capital Medical University, Beijing 100069, China.

Background: The incidence of cryptococcal meningitis among immunocompetent patients increases, especially in China and imaging plays an important role. The current study was to find the correlation between magnetic resonance imaging (MRI) manifestation and clinical severity in nonhuman immunodeficiency virus patients with cryptococcal infection of central nervous system (CNS).

Methods: A total of 65 patients with CNS cryptococcal infection from August 2014 to October 2016 were retrospectively included in this study. Read More

Chin Med J (Engl) 2018 Dec;131(24):2915-2920

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background: Few studies have been published on new-onset geriatric epilepsy especially in older Chinese people. This study was to have a comprehensive understanding of new-onset geriatric epilepsy and find a more reasonable diagnosis and management of epilepsy in older people.

Methods: One hundred and three patients with onset age 60 years and older were admitted between January 2008 and December 2016. Read More

Chin Med J (Engl) 2018 Dec;131(24):2904-2909

Department of Neurology, Peking Union Medical College Hospital; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100730, China.

Background: Ongoing efforts have been made to identify new neuroimaging markers to track amyotrophic lateral sclerosis (ALS) progression. This study aimed to explore the monitoring value of multimodal magnetic resonance imaging (MRI) in the disease progression of ALS.

Methods: From September 2015 to March 2017, ten patients diagnosed with ALS in Peking Union Medical College Hospital completed head MRI scans at baseline and during follow-up. Read More

Chin Med J (Engl) 2018 Dec;131(24):2899-2903

Department of Neurology, Xuanwu Hospital, Capital Medical University; Beijing Key Laboratory of Neuromodulation, Beijing 100053; Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China.

Neural Regen Res 2019 Mar;14(3):446-449

NYU Langone Eye Center, Department of Ophthalmology, NYU School of Medicine, NYU Langone Health; Department of Radiology, NYU School of Medicine, NYU Langone Health; Center for Neural Science, Faculty of Arts and Science, New York University, New York, NY, USA.

Glaucoma, the world's leading cause of irreversible blindness, is a condition for which elevated intraocular pressure is currently the only modifiable risk factor. However, the disorder can continue to progress even at reduced intraocular pressure. This indicates additional key factors that contribute to the etiopathogenesis. Read More

Neural Regen Res 2019 Mar;14(3):413-424

Regenerative Bioscience Center; Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA.

Traumatic brain injury (TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the development of functional impairments. However, there are currently no effective therapeutic interventions that improve brain outcomes following TBI. Read More

Neural Regen Res 2019 Mar;14(3):373-386

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences; Center for Biomedical Imaging at Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA.

Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Environmental and genetic factors are associated with the risk of developing MS, but the exact cause still remains unidentified. Epstein-Barr virus (EBV), vitamin D, and smoking are among the most well-established environmental risk factors in MS. Read More

Schizophr Res 2018 Dec 30;202:149-157. Epub 2018 Jun 30.

Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Rudolf-Bultmann-Straße 8, 35039 Marburg, Germany.

Humor is a ubiquitous human ability with important implications for both social and emotional functioning. Patients with neuropsychiatric disorders, such as schizophrenia, experience difficulties in the comprehension and appreciation of humor. However, the specific neural mechanisms underlying these deficits are unknown. Read More

Eur J Radiol 2018 Dec 21;109:235-247. Epub 2018 Oct 21.

Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 19/P, 8036 Graz, Austria; Research & Development, Siemens Healthcare Diagnostics GmbH, Strassgangerstrasse 315, 8054 Graz, Austria. Electronic address:

Non-invasive identification and differentiation of myocardial diseases represents the primary objectives of cardiac magnetic resonance (CMR) longitudinal relaxation time (T1) and extracellular volume (ECV) mapping. Given the fact that myocardial T1 and ECV values overlap throughout and within left ventricular phenotypes, a central issue to be addressed is whether and to what extent myocardial T1 and ECV mapping provides additional or superior diagnostic information to standard CMR imaging, and whether native T1 mapping could be employed as a non-contrast alternative to late gadolinium enhancement (LE) imaging. The present review aims to summarize physiological and pathophysiological alterations in native T1 and ECV values and summarized myocardial T1 and ECV alterations associated with cardiac diseases to support the translation of research findings into routine CMR imaging. Read More

Eur J Radiol 2018 Dec 13;109:223-234. Epub 2018 Oct 13.

Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 19/P, 8036 Graz, Austria. Electronic address:

While an enormous number of studies have documented pathological alterations of the myocardial native longitudinal relaxation time (T1) and the fraction of the extracellular myocardial volume (ECV), it has also become clear that continuously evolving T1 mapping sequence, acquisition and evaluation techniques have a substantial impact on quantitative results, making the translation of reported findings into routine clinical use particularly challenging. To provide a basis for the discussion of pathological myocardial T1 and ECV alterations, the present review aims to summarize the methodological aspects of myocardial T1 mapping along with technical and physiological factors influencing results and normal ranges of myocardial native T1 and ECV reported across studies. Read More

Psychiatry Res Neuroimaging 2018 Dec 30;282:126-131. Epub 2018 Jun 30.

Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa 56126, Italy.

Leukoaraiosis is one of the main contributors to mild cognitive impairment due to vascular damage (vascular MCI, VMCI), whose pathophysiology has not been fully elucidated yet. We aimed to shed light on such issue using functional MRI (fMRI). Sixteen patients with VMCI were enrolled and compared with twenty-five patients with MCI but without significant vascular damage (non-vascular MCI, NVMCI) and with fifteen healthy controls (HC). Read More

Vasa 2018 Dec 12:1-7. Epub 2018 Dec 12.

2 1st Department of Neurology, Aristotle University of Thessaloniki, AHEPA University General Hospital, Thessaloniki, Greece.

Background: Carotid dissection is a rare disease, mainly affecting young and middle-aged patients potentially ending up in stroke. Multimodality imaging plays an essential role, both in terms of prompt and accurate diagnosis and follow-up of this entity.

Patients And Methods: We herein present a case series of patients with internal carotid artery dissection and compare the various imaging findings of ultrasonography, multidetector computed tomography angiography and magnetic resonance angiography, with a purpose to illustrate the value of multimodality imaging in the diagnosis of carotid dissection. Read More

Methods Mol Biol 2019 ;1904:377-400

Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang, Malaysia.

Panning is a common process used for antibody selection from phage antibody libraries. There are several methods developed for a similar purpose, namely streptavidin mass spectrometry immunoassay (MSIA™) Disposable Automation Research Tips, magnetic beads, polystyrene immunotubes, and microtiter plate. The advantage of using a magnetic particle processor system is the ability to carry out phage display panning against multiple target antigens simultaneously in parallel. Read More

Methods Mol Biol 2019 ;1897:403-416

Drug Discovery Laboratory, Department of Neurology, Mary S. Easton Center for Alzheimer's Disease Research, University of California, Los Angeles, Los Angeles, CA, USA.

Analyses of bloodborne nanoscale extracellular vesicles (nsEVs) have shown tremendous promise in enabling the development of noninvasive blood-based clinical diagnostic tests, predicting and monitoring the efficacy of treatment programs, and identifying new drug targets in the context of health conditions such as cancer and Alzheimer's disease. In this chapter we present a protocol for generating global nsEV proteomic profiles that can further the utility of nsEV analysis for the above biomedical applications by enlightening us of differences in protein abundance across normal and disease state nsEVs. This protocol features the use of magnetic particle-based immunoprecipitation to enrich highly purified populations of nsEVs directly from plasma or serum samples. Read More

Knee Surg Sports Traumatol Arthrosc 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopaedic Sports Medicine, Klinikum Rechts der Isar, Technical University Munich, Ismaningerstr. 22, 81675, Munich, Germany.

Purpose: Acute meniscus repair in young athletes is always a challenge due to the long rehabilitation process and time to return to sport (RTS). The purpose was to investigate signal alterations in short-term follow-up after acute meniscus repair on specific magnetic resonance imaging (MRI) scan sequences. It was hypothesized that (1) MRI signal changes over the first postoperative healing phase and represent a continuous healing process and (2) meniscus healing properties correlates with clinical outcomes and RTS. Read More

Knee Surg Sports Traumatol Arthrosc 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: The purpose of this study was to reveal the relation between age and the morphological characteristics of the anterior cruciate ligament (ACL) using magnetic resonance imaging (MRI).

Methods: Thirty-seven young subjects who were diagnosed with a meniscus injury without ACL tear using MRI (15 male and 22 female, median age 26, range 15-49), and 33 elderly subjects for whom knee MRI was performed before uni-compartmental knee arthroplasty (11 male and 22 female, median age 77, range 60-83), were included in this study. In the elderly group, healthy ACL gross morphology was confirmed macroscopically during surgery. Read More

Arch Orthop Trauma Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedics and Traumatology, School of Medicine, University of São Paulo, Rua Dr. Ovídio Pires de Campos 333, 3rd Floor, São Paulo, SP, 05403-010, Brazil.

Introduction: The accuracy of MRI for subscapularis tear is lower than that of overall rotator cuff tears. Until now, no systematic reviews and meta-analysis have been conducted to compile these data. The purpose of this study was to determine, through a systematic review and meta-analysis, the diagnostic accuracy of MRI in the detection of subscapularis tendon tears. Read More

Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiology, Hospital Sírio-Libanês, Adma Jafet, 91, Bela Vista, São Paulo, SP, 01308-050, Brazil.

Purpose: The aim of this study is to provide an overview of endometriosis-associated neuropathy and to review main anatomical concepts of intrapelvic peripheral nerves.

Methods: In this pictorial essay, we review the anatomy of pelvic nerves and imaging features of endometriosis-associated neuropathy. We also evaluate clinical findings, imaging features, and outcome of seven patients with endometriosis-associated neuropathy. Read More

Unfallchirurg 2018 Dec 11. Epub 2018 Dec 11.

Abteilung für Plastische, Hand- und Rekonstruktive Chirurgie, BG Unfallklinik Frankfurt, Friedberger Landstr. 430, 60389, Frankfurt am Main, Deutschland.

Background: Fractures of the scaphoid bone are common but can easily be overlooked in standard X‑rays. Inadequate diagnostics and therefore inappropriate treatment of scaphoid fractures often leads to problems in healing with formation of non-union and painful osteoarthritis of the wrist.

Objective: This review summarizes the current practical recommendations in the diagnostics and treatment of acute scaphoid fractures. Read More

Pediatr Cardiol 2018 Dec 11. Epub 2018 Dec 11.

Division of Pediatric Cardiology, University of Nebraska College of Medicine and Children's Hospital and Medical Center, 8200 Dodge St, Omaha, NE, 68114, USA.

Quantification of pulmonary regurgitation (PR), pulmonary flow distribution, and ventricular function is important for clinical surveillance in repaired Tetralogy of Fallot (TOF). Cardiovascular magnetic resonance (CMR) is the established reference, but cost, test duration, and patient discomfort are potential limitations to its serial use. We investigated whether an Abbreviated CMR protocol would alter clinical decisions in TOF from those that would have been made using a full protocol. Read More

Int Orthop 2018 Dec 11. Epub 2018 Dec 11.

Unità Operativa C.A.S.C.O, IRCCS Istituto Ortopedico Galeazzi, 20161, Milan, Italy.

Purpose: The aim of our study is to evaluate the long-term results in patients treated with a fully arthroscopic TruFit system for osteochondral lesions of the femoral condyle, analyzing the clinical and radiological outcomes, survival rate, complications, and correlations.

Methods: The study included all patients treated with the TruFit system with a full-thickness focal lesion of the knee cartilage (grade IV according to the ICRS classification), entirely arthroscopically with a minimum follow-up of five years. All patients were evaluated clinically prior to surgery (T) and at two consecutive follow-ups (T 36. Read More