36,136 results match your criteria Magnetic Resonance Imaging in Acute Stroke


Trillium tschonoskii rhizomes' saponins induces oligodendrogenesis and axonal reorganization for ischemic stroke recovery in rats.

J Ethnopharmacol 2021 Jun 21:114358. Epub 2021 Jun 21.

School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China; Beijing Key Lab of TCM Collateral Disease Theory Research, Beijing, 100069, China. Electronic address:

Ethnopharmacological Relevance: Trillium tschonoskii Maxim. is one of traditional Chinese medical herbs that has been utilized to treat brain damages and cephalalgia. The neuroprotective effect of total saponins from Trillium tschonoskii rhizome (TSTT) has been demonstrated efficacy in rats following ischemia. Read More

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Visualizing Oxidative Stress Level for Timely Assessment of Ischemic Stroke a Ratiometric Near-Infrared-II Luminescent Nanoprobe.

ACS Nano 2021 Jun 24. Epub 2021 Jun 24.

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.

Ischemic stroke (IS) characterized with high morbidity and mortality rates is considered as one of the most dangerous brain diseases. The timely assessment of IS is crucial for making a clinical decision due to the severity of IS featured with time-dependence. Herein, we develop a highly reactive oxygen species (HROS)-responsive ratiometric near-infrared-II (NIR-II) nanoprobe based on a dye-sensitized system between IR-783 dye and lanthanide-doped nanoparticles. Read More

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Disparate trends of atherosclerotic plaque evolution in stroke patients under 18-month follow-up: a 3D whole-brain magnetic resonance vessel wall imaging study.

Neuroradiol J 2021 Jun 23:19714009211026920. Epub 2021 Jun 23.

Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, USA.

Purpose: The trend of atherosclerotic plaque feature evolution is unclear in stroke patients with and without recurrence. We aimed to use three-dimensional whole-brain magnetic resonance vessel wall imaging to quantify the morphological changes of causative lesions during medical therapy in patients with symptomatic intracranial atherosclerotic disease.

Methods: Patients with acute ischemic stroke attributed to intracranial atherosclerotic disease were retrospectively enrolled if they underwent both baseline and follow-up magnetic resonance vessel wall imaging. Read More

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Segmentation of MRI head anatomy using deep volumetric networks and multiple spatial priors.

J Med Imaging (Bellingham) 2021 May 17;8(3):034001. Epub 2021 Jun 17.

City College New York, Department of Biomedical Engineering, New York City, New York, United States.

Conventional automated segmentation of the head anatomy in magnetic resonance images distinguishes different brain and nonbrain tissues based on image intensities and prior tissue probability maps (TPMs). This works well for normal head anatomies but fails in the presence of unexpected lesions. Deep convolutional neural networks (CNNs) leverage instead spatial patterns and can learn to segment lesions but often ignore prior probabilities. Read More

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Penumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial.

Stroke 2021 Jun 23:STROKEAHA120033806. Epub 2021 Jun 23.

Department of Neurology, University of Utah, Salt Lake City (A.d.H.).

Background And Purpose: In patients with acute large vessel occlusion, the natural history of penumbral tissue based on perfusion time-to-maximum (T) delay is not well established in relation to late-window endovascular thrombectomy. In this study, we sought to evaluate penumbra consumption rates for T delays in patients with large vessel occlusion evaluated between 6 and 16 hours from last known normal.

Methods: This is a post hoc analysis of the DEFUSE 3 trial (The Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke), which included patients with an acute ischemic stroke due to anterior circulation occlusion within 6 to 16 hours of last known normal. Read More

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Left Ventricular Noncompaction Cardiomyopathy as a Potential Cause of Bilateral Posterior Cerebral Artery Stroke - a Rare and Unique Clinical Occurrence.

Am J Case Rep 2021 Jun 22;22:e931103. Epub 2021 Jun 22.

Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.

BACKGROUND Bilateral posterior cerebral artery (PCA) occlusions are exceedingly rare, and are considered a devastating phenomenon that presents as cortical blindness. Predominant causes of PCA infarcts include cardiac and arterial embolisms. Left ventricular noncompaction (LVNC) cardiomyopathy is also an extremely rare cardiopathology. Read More

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QSIPrep: an integrative platform for preprocessing and reconstructing diffusion MRI data.

Nat Methods 2021 Jun 21. Epub 2021 Jun 21.

University of Pennsylvania, Philadelphia, PA, USA.

Diffusion-weighted magnetic resonance imaging (dMRI) is the primary method for noninvasively studying the organization of white matter in the human brain. Here we introduce QSIPrep, an integrative software platform for the processing of diffusion images that is compatible with nearly all dMRI sampling schemes. Drawing on a diverse set of software suites to capitalize on their complementary strengths, QSIPrep facilitates the implementation of best practices for processing of diffusion images. Read More

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The effects of traditional Chinese medicine sensory stimulation combined with transcranial direct current stimulation on deglutition and related complications in stroke patients with dysphagia: a randomized trial.

Ann Palliat Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Nursing, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Background: Stroke is a serious manifestation of a variety of cerebrovascular diseases and can cause significant morbidity and mortality. This study explored the effects of traditional Chinese medicine (TCM) sensory stimulation combined with transcranial direct current stimulation (tDCS) on swallowing function and related complications in stroke patients with dysphagia.

Methods: A total of 60 stroke patients with deglutition dysfunction admitted to our hospital from August 2019 to January 2021 were selected as research subjects. Read More

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Spontaneous spinal epidural hemorrhage and sentinel headache-A case report.

Headache 2021 Jun 21. Epub 2021 Jun 21.

University of South Carolina School of Medicine, Greenville, SC, USA.

Objectives/background: Expand the differential diagnosis of sentinel headache to include spontaneous spinal epidural hematoma (SSEH) and reinforce the need for lumbar puncture in the evaluation of thunderclap headache. SSEH is a rare clinical presentation especially in the absence of bleeding tendencies. Clinicians recognize SSEH with typical presenting signs and symptoms including regional paraspinal muscular contraction and pain along with myelopathy. Read More

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A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease.

Front Physiol 2021 2;12:644837. Epub 2021 Jun 2.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.

Background: Cerebrovascular reactivity (CVR) measures blood flow change in response to a vasoactive stimulus. Impairment is associated with several neurological conditions and can be measured using blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI). Field strength affects the BOLD signal, but the effect on CVR is unquantified in patient populations. Read More

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[A case of cerebral embolism with Coronavirus disease 2019].

Rinsho Shinkeigaku 2021 Jun 18. Epub 2021 Jun 18.

Department of Neurology, Fukuoka City Hospital.

A 63-year-old man, who had persistent fever for a month, was admitted to the hospital with sudden left arm palsy with a National Institutes of Health Stroke Scale score of 3. Consequently, brain MRI showed hyperintensity of the bilateral occipital, right parietal, and right frontal lobes on diffusion-weighted imaging. Moreover, FLAIR presented hyperintensity of the left occipital lobe. Read More

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Characteristics of high-resolution magnetic resonance vessel wall imaging of cervicocerebral artery dissection and the influential factors of vascular recanalization.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 May;46(5):467-474

Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objectives: Cervicocerebral artery dissection (CAD) is one of the important causes for ischemic stroke in young and middle-aged people. CAD is dangerous and untimely diagnosis and treatment are likely to result in severe disability. Early diagnosis and timely intervention can greatly improve the prognosis of patients. Read More

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Cognition-Related Functional Topographies in Parkinson's Disease: Localized Loss of the Ventral Default Mode Network.

Cereb Cortex 2021 Jun 19. Epub 2021 Jun 19.

Center for Neurosciences, The Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.

Cognitive dysfunction in Parkinson's disease (PD) is associated with increased expression of the PD cognition-related pattern (PDCP), which overlaps with the normal default mode network (DMN). Here, we sought to determine the degree to which the former network represents loss of the latter as a manifestation of the disease process. To address this, we first analyzed metabolic images (fluorodeoxyglucose positron emission tomography [PET]) from a large PD sample with varying cognitive performance. Read More

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Automated left atrial time-resolved segmentation in MRI long-axis cine images using active contours.

BMC Med Imaging 2021 Jun 19;21(1):101. Epub 2021 Jun 19.

Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, Connecticut, United States of America.

Background: Segmentation of the left atrium (LA) is required to evaluate atrial size and function, which are important imaging biomarkers for a wide range of cardiovascular conditions, such as atrial fibrillation, stroke, and diastolic dysfunction. LA segmentations are currently being performed manually, which is time-consuming and observer-dependent.

Methods: This study presents an automated image processing algorithm for time-resolved LA segmentation in cardiac magnetic resonance imaging (MRI) long-axis cine images of the 2-chamber (2ch) and 4-chamber (4ch) views using active contours. Read More

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Multi-view Iterative Random Walker for Automated Salvageable Tissue Delineation in Ischemic Stroke from Multi-Sequence MRI.

J Neurosci Methods 2021 Jun 16:109260. Epub 2021 Jun 16.

Department of Electrical Engineering, Indian Institute of Technology, Kharagpur, India-721302. Electronic address:

Background And Objective: Non-invasive and robust identification of salvageable tissue (penumbra) is crucial for interventional stroke therapy. Besides identifying stroke injury as a whole, the ability to automatically differentiate core and penumbra tissues, using both diffusion and perfusion magnetic resonance imaging (MRI) sequences is essential for ischemic stroke treatment.

Method: A fully automated and novel one-shot multi-view iterative random walker (MIRW) method with an automated injury seed point detection is developed for lesion delineation. Read More

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Urinary sodium and potassium excretion and cerebrovascular health: a multimodal imaging study.

Eur J Nutr 2021 Jun 19. Epub 2021 Jun 19.

Center for Kidney Disease, Second Affiliated Hospital of Nanjing Medical University, 262# Zhongshan North Road, Nanjing, Jiangsu, China.

Purpose: Dietary sodium and potassium intake are associated with stroke, but the potential mechanisms are unclear. We aimed to study the association between sodium and potassium intake and subclinical cerebrovascular health in hypertensive older males using multimodal magnetic resonance imaging.

Methods: A total of 189 hypertensive male subjects without previous cardiovascular or cerebrovascular disease were included. Read More

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Decreasing Spatial Variability of Individual Watershed Areas by Revascularization Therapy in Patients With High-Grade Carotid Artery Stenosis.

J Magn Reson Imaging 2021 Jun 18. Epub 2021 Jun 18.

Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich (TUM), Germany.

Background: Carotid artery stenosis can impair cerebral hemodynamics especially within watershed areas (WSAs) between vascular territories. WSAs can shift because of collateral flow, which may be an indicator for increased hemodynamic implications and hence higher risk for ischemic stroke. However, whether revascularization treatment can reverse the spatial displacement of individual WSAs (iWSAs) and impaired hemodynamics remains unknown. Read More

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U-Limb: A multi-modal, multi-center database on arm motion control in healthy and post-stroke conditions.

Gigascience 2021 Jun;10(6)

Research Center "Enrico Piaggio" and Dipartimento di Ingegneria dell'Informazione, University of Pisa Largo Lucio Lazzarino 1, 56122 Pisa, Italy.

Background: Shedding light on the neuroscientific mechanisms of human upper limb motor control, in both healthy and disease conditions (e.g., after a stroke), can help to devise effective tools for a quantitative evaluation of the impaired conditions, and to properly inform the rehabilitative process. Read More

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Clinical intra-cardiac 4D flow CMR: acquisition, analysis, and clinical applications.

Eur Heart J Cardiovasc Imaging 2021 Jun 18. Epub 2021 Jun 18.

Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Identification of flow patterns within the heart has long been recognized as a potential contribution to the understanding of physiological and pathophysiological processes of cardiovascular diseases. Although the pulsatile flow itself is multi-dimensional and multi-directional, current available non-invasive imaging modalities in clinical practice provide calculation of flow in only 1-direction and lack 3-dimensional volumetric velocity information. Four-dimensional flow cardiovascular magnetic resonance imaging (4D flow CMR) has emerged as a novel tool that enables comprehensive and critical assessment of flow through encoding velocity in all 3 directions in a volume of interest resolved over time. Read More

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Expert opinion paper on cardiac imaging after ischemic stroke.

Clin Res Cardiol 2021 Jun 18. Epub 2021 Jun 18.

Atrial Fibrillation NETwork (AFNET) e.V., Münster, Germany.

This expert opinion paper on cardiac imaging after acute ischemic stroke or transient ischemic attack (TIA) includes a statement of the "Heart and Brain" consortium of the German Cardiac Society and the German Stroke Society. The Stroke Unit-Commission of the German Stroke Society and the German Atrial Fibrillation NETwork (AFNET) endorsed this paper. Cardiac imaging is a key component of etiological work-up after stroke. Read More

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Extent and determinants of left ventricular reverse remodeling in patients with secondary mitral regurgitation undergoing MitraClip implantation.

Int J Cardiol Heart Vasc 2021 Jun 3;34:100804. Epub 2021 Jun 3.

Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Duesseldorf, Heinrich-Heine University Duesseldorf, Medical Faculty, Moorenstraße 5, 40225 Duesseldorf, Germany.

Background: In secondary MR, data on left ventricular (LV) remodeling after MitraClip procedure are rare, even this information may impact patient selection. This study investigated changes in LV structure and function by cardiovascular magnetic resonance (CMR) following MitraClip implantation for secondary mitral regurgitation (MR) in order to assess extent and predictors of LV reverse remodeling (LVRR).

Methods And Results: Twenty-nine patients underwent CMR imaging prior to and six months after MitraClip procedure. Read More

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Common genetic variation influencing human white matter microstructure.

Science 2021 06;372(6548)

Biomedical Research Imaging Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Brain regions communicate with each other through tracts of myelinated axons, commonly referred to as white matter. We identified common genetic variants influencing white matter microstructure using diffusion magnetic resonance imaging of 43,802 individuals. Genome-wide association analysis identified 109 associated loci, 30 of which were detected by tract-specific functional principal components analysis. Read More

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Brain Infarction MRI Pattern in Stroke Patients with Intracardiac Thrombus.

Cerebrovasc Dis 2021 Jun 17:1-7. Epub 2021 Jun 17.

Department of Neurology, CHU Nîmes, University of Montpellier, Nîmes, France.

Background: Acute infarction patterns have been described in cardioembolic stroke, mainly with atrial fibrillation (AF) or patent foramen ovale. We aimed to analyse acute infarction magnetic resonance imaging (MRI) characteristics in stroke patients with intracardiac thrombus (ICT) compared with stroke patients with AF.

Methods: We performed a retrospective study analysing brain MRI scans of consecutive acute symptomatic cardioembolic infarction patients associated with ICT or AF who were recruited and registered in the stroke database between June 2018 and November 2019. Read More

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2021 MAGNIMS-CMSC-NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis.

Lancet Neurol 2021 Jun 14. Epub 2021 Jun 14.

Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address:

The 2015 Magnetic Resonance Imaging in Multiple Sclerosis and 2016 Consortium of Multiple Sclerosis Centres guidelines on the use of MRI in diagnosis and monitoring of multiple sclerosis made an important step towards appropriate use of MRI in routine clinical practice. Since their promulgation, there have been substantial relevant advances in knowledge, including the 2017 revisions of the McDonald diagnostic criteria, renewed safety concerns regarding intravenous gadolinium-based contrast agents, and the value of spinal cord MRI for diagnostic, prognostic, and monitoring purposes. These developments suggest a changing role of MRI for the management of patients with multiple sclerosis. Read More

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[Posterior reversible encephalopathy syndrome in transplanted patients. Clinical features and imaging follow up].

Medicina (B Aires) 2021 ;81(3):359-366

Centro de Stroke, Hospital Universitario Fundación Favaloro, Universidad Favaloro, Buenos Aires, Argentina.

Posterior reversible encephalopathy syndrome (PRES) is an acute neurological disorder characterized by headache, encephalopathy, seizures and visual disturbances, with reversible vasogenic edema in posterior brain areas. The aim of this research was to describe a case series of transplanted patients who developed PRES, characterize their presentation, treatment, clinical and imaging evolution. Electronic medical records were analyzed from January 2009 to January 2019. Read More

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Stroke Outcome Prediction Using Admission Nihss In Anterior And Posterior Circulation Stroke.

J Ayub Med Coll Abbottabad 2021 Apr-Jun;33(2):274-278

Shifa College of Medicine and Shifa International Hospital, Islamabad, Pakistan.

Background: Stroke is a worldwide disease with high morbidity. Various scales are used to measure the severity and outcome of stroke. National Institute of Health Stroke Scale (NIHSS) is a quantifiable scale used to assess stroke severity. Read More

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A neutrophil-mimetic magnetic nanoprobe for molecular magnetic resonance imaging of stroke-induced neuroinflammation.

Biomater Sci 2021 Jun 17. Epub 2021 Jun 17.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, P.R. China.

Neuroinflammation plays a key role in the progression of brain injury induced by stroke, and has become a promising target for therapeutic intervention for stroke. Monitoring this pivotal process of neuroinflammation is highly desirable to guide specific therapy. However, there is still a lack of a satisfactory nanoprobe to selectively monitor neuroinflammation. Read More

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Machine learning approaches to predicting amyloid status using data from an online research and recruitment registry: The Brain Health Registry.

Alzheimers Dement (Amst) 2021 9;13(1):e12207. Epub 2021 Jun 9.

Department of Veterans Affairs Medical Center Northern California Institute for Research and Education (NCIRE) San Francisco California USA.

Introduction: This study investigated the extent to which subjective and objective data from an online registry can be analyzed using machine learning methodologies to predict the current brain amyloid beta (Aβ) status of registry participants.

Methods: We developed and optimized machine learning models using data from up to 664 registry participants. Models were assessed on their ability to predict Aβ positivity using the results of positron emission tomography as ground truth. Read More

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C-reactive Protein for Stroke Detection in the Emergency Department in Patients With Dizziness Without Neurological Deficits.

Front Neurol 2021 31;12:662510. Epub 2021 May 31.

Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Stroke diagnosis can be challenging in patients with dizziness without neurologic deficits. The aim of this study was to evaluate the predictive value of C-reactive protein (CRP) for identifying acute stroke in such patients. Data from adult patients (>18 years) admitted to the emergency department from August 2019 to February 2020 were evaluated. Read More

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Cerebral Small Vessel Disease Associated With Atrial Fibrillation Among Older Adults: A Population-Based Study.

Stroke 2021 Jun 17:STROKEAHA120031573. Epub 2021 Jun 17.

Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm University, Sweden. (M.D., R.W., G.K., E.J.L., Y.L., L.F., C.Q.).

Background And Purpose: Cerebral small vessel disease, as a potential mechanism underlying the association between atrial fibrillation (AF) and dementia, remains poorly investigated. In this cohort study, we sought to examine the association between AF and cerebral small vessel disease markers among older adults.

Methods: Data on 336 participants (age ≥60 years, mean 70. Read More

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