30,672 results match your criteria Magnetic Resonance Imaging in Acute Stroke


Siponimod (BAF312) Treatment Reduces Brain Infiltration but Not Lesion Volume in Middle-Aged Mice in Experimental Stroke.

Stroke 2019 May;50(5):1224-1231

From the Department of Neurology (A.V., J.R., A.D., J.S.), University Medicine, Greifswald, Germany.

Background and Purpose- The contribution of neuroinflammation and, in particular, the infiltration of the brain by lymphocytes is increasingly recognized as a substantial pathophysiological mechanism after stroke. The interaction of lymphocytes with endothelial cells and platelets, termed thromboinflammation, fosters microvascular dysfunction and secondary infarct growth. Siponimod is an S1PR (sphingosine-1-phosphate receptor) modulator, which blocks the egress of lymphocytes from lymphoid organs and has demonstrated beneficial effects in multiple sclerosis treatment. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023667DOI Listing

Acute Stroke With Large Ischemic Core Treated by Thrombectomy.

Stroke 2019 May;50(5):1164-1171

Department of Neurology, Foch Hospital, Versailles Saint-Quentin en Yvelines University, Suresnes, France (B.L.).

Background and Purpose- Acute stroke patients with a large ischemic core may still benefit from mechanical thrombectomy (MT), but the predictors of clinical outcome are not well known after MT. We investigated the clinical and imaging factors associated with good outcome and mortality at 90 days in acute stroke patients with a large baseline ischemic core treated with MT. Methods- Data from the multicentric prospective ETIS (Endovascular Treatment in Ischemic Stroke) registry of consecutive acute ischemic stroke patients treated with MT from January 1, 2012, to August 31, 2016, were retrospectively analyzed. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.024295DOI Listing

Combining Neurovascular and Neurodegenerative Magnetic Resonance Imaging Measures in Stroke.

Stroke 2019 May;50(5):1136-1139

From the Institute of Cardiovascular and Medical Sciences, University of Glasgow, Queen Elizabeth University Hospital, United Kingdom (A.W., J.D., D.A.D.).

Background and Purpose- Individual markers of cerebral small vessel disease and cerebral atrophy explain a small proportion of variance in vascular risk factors and cognitive function. Combining these markers into a single measure of neurovascular and neurodegenerative disease may be more powerful. We assessed this using data contained in the Virtual International Stroke Trials Archive - Prevention sub-archive. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.024181DOI Listing

Multimodal magnetic resonance imaging to identify stroke onset within 6 h in patients with large vessel occlusions.

Eur Stroke J 2018 Jun 1;3(2):185-192. Epub 2018 Feb 1.

Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven - University of Leuven, Leuven, Belgium.

Introduction: Mechanical thrombectomy within 6 h after stroke onset improves the outcome in patients with large vessel occlusions. The aim of our study was to establish a model based on diffusion weighted and perfusion weighted imaging to provide an accurate prediction for the 6 h time-window in patients with unknown time of stroke onset.

Patients And Methods: A predictive model was designed based on data from the DEFUSE 2 study and validated in a subgroup of patients with large vessel occlusions from the AXIS 2 trial. Read More

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http://dx.doi.org/10.1177/2396987317753486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460412PMC

The impact of early-life intelligence quotient on post stroke cognitive impairment.

Eur Stroke J 2018 Jun 8;3(2):145-156. Epub 2018 Jan 8.

3Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh.

Background: Cognitive impairment can complicate minor stroke, but there is limited information on risk factors including peak cognitive ability earlier in life.

Methods: We recruited patients with clinically-evident lacunar or minor non-lacunar ischaemic stroke, recorded clinical features, vascular risk factors, magnetic resonance imaging-detected stroke sub-type and small vessel disease burden. At 1-3 and 12 months after stroke, we assessed educational attainment (years of education), current cognition (Addenbrooke's Cognitive Examination-Revised), pre-morbid intelligence (National Adult Reading Test) and dependency (modified Rankin Scale). Read More

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http://dx.doi.org/10.1177/2396987317750517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460404PMC

Leptomeningeal anastomosis and early ischemic lesions on diffusion-weighted imaging in male murine focal cerebral ischemia.

J Neurosci Res 2019 Apr 21. Epub 2019 Apr 21.

Department of Neurology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.

Leptomeningeal anastomosis is a key factor for determining early ischemic lesions on diffusion-weighted imaging (DWI) in human stroke. However, few studies have validated this relationship in an experimental model. This study sought to clarify the involvement of leptomeningeal anastomosis in early ischemic lesions using a murine model. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jnr.24403
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http://dx.doi.org/10.1002/jnr.24403DOI Listing
April 2019
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Effectiveness of Nonvitamin K Antagonist Oral Anticoagulants and Warfarin for Preventing Further Cerebral Microbleeds in Acute Ischemic Stroke Patients with Nonvalvular Atrial Fibrillation and At Least One Microbleed: CMB-NOW Multisite Pilot Trial.

J Stroke Cerebrovasc Dis 2019 Apr 18. Epub 2019 Apr 18.

Departments of Neurology, Tokai University School of Medicine, Isehara, Tokyo, Japan. Electronic address:

Background: Nonvitamin K antagonist oral anticoagulants (NOACs) are considered superior, or at least noninferior, to warfarin in preventing stroke or systemic embolism in patients with nonvalvular atrial fibrillation. Here, we recruited acute ischemic stroke patients with nonvalvular atrial fibrillation and at least one cerebral microbleed (CMB), and evaluated the proportion of patients who had an increased number of CMBs (%) after receiving anticoagulant therapy with NOACs or with warfarin for 12 months.

Methods: This was a multicenter, prospective, observational cohort study at 20 centers, conducted between 2015 and 2017, in which we recruited 85 patients with at least one CMB detected by 1. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.050DOI Listing

Left Atrial Mechanical Function and Incident Ischemic Cerebrovascular Events Independent of AF.

JACC Cardiovasc Imaging 2019 Apr 10. Epub 2019 Apr 10.

Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

Objectives: This study sought to assess the association of baseline left atrial (LA) phasic function measured with cardia magnetic resonance (CMR) and incident ischemic cerebrovascular events (CVE).

Background: LA remodeling is a known predictor of atrial fibrillation (AF), which is a risk factor for ischemic CVE. Despite studies showing an association between LA remodeling and ischemic CVE, the association of LA mechanical function with ischemic CVE in a population free of known cardiovascular disease is not fully studied. Read More

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http://dx.doi.org/10.1016/j.jcmg.2019.02.021DOI Listing

Epileptic spasm and other forms of epilepsy in presumed perinatal arterial ischemic stroke in Turkey after more than 10 years follow-up: A single centre study.

Brain Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Neuroradiology, Istanbul Faculty of Medicine, Istanbul, Turkey.

Purpose: To identify the frequency of epilepsy and whether the association of epilepsy with clinical and neuroimaging findings in children with presumed perinatal arterial ischemic stroke (PPAIS).

Methods: We performed a retrospective analysis of 37 children with PPAIS followed-up at a tertiary referral center between January 1, 2000, and October 31, 2016. Clinical data including demographic features, age at onset of symptoms and seizures, initial clinical presentation, epilepsy features, used antiepileptic drugs, and thrombophilia screening results were abstracted from medical records. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604193009
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http://dx.doi.org/10.1016/j.braindev.2019.04.004DOI Listing
April 2019
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Association between excessive supraventricular ectopy and subclinical cerebrovascular disease: A population-based study.

Eur J Neurol 2019 Apr 19. Epub 2019 Apr 19.

Department of Public Health, Shiga University of Medical Science, Otsu, Japan.

Background: The association between an increased supraventricular ectopic beat (SVEB) and subclinical cerebrovascular disease remains unclear. Given the emerging concept that an increased SVEB is a marker of atrial cardiomyopathy or atherosclerosis burden, we sought to determine whether excessive supraventricular ectopic activity (ESVEA) is associated with a higher burden of subclinical cerebrovascular disease in the middle-aged to older cohort with neither apparent stroke nor atrial fibrillation.

Methods: We conducted a cross-sectional population-based study of 462 men (mean age, 68. Read More

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http://dx.doi.org/10.1111/ene.13970DOI Listing

Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study.

JAMA Netw Open 2019 Apr 5;2(4):e192745. Epub 2019 Apr 5.

Framingham Heart Study, Framingham, Massachusetts.

Importance: Dementia risk may be attenuated by physical activity (PA); however, the specific activity levels optimal for dementia prevention are unclear. Moreover, most older adults are unable to meet the nationally recommended PA guidelines, set at 150 minutes of moderate to vigorous PA per week.

Objective: To assess the association of total steps walked per day and total dose (intensity × duration) of PA with brain volumes on magnetic resonance imaging (MRI) among Framingham Heart Study participants. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2745DOI Listing

Low-Grade Inflammation Is Associated with Apathy Indirectly via Deep White Matter Lesions in Community-Dwelling Older Adults: The Sefuri Study.

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

Division of Clinical Research, National Hospital Organization Hizen Psychiatric Center, Saga 842-0192, Japan.

Low-grade inflammation is implicated in the pathogenesis of atherosclerosis, metabolic syndrome, and apathy as a form of vascular depression. We analyzed the brain magnetic resonance imaging findings in 259 community-dwelling older adults (122 men and 137 women, with a mean age of 68.4 years). Read More

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https://www.mdpi.com/1422-0067/20/8/1905
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http://dx.doi.org/10.3390/ijms20081905DOI Listing
April 2019
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Apical hypertrophic cardiomyopathy with preexcitation presenting as a myocardial infarction and ischemic stroke with a history of recurrent syncope: A case report.

Clin Case Rep 2019 Apr 14;7(4):816-820. Epub 2019 Mar 14.

Centre for Research and Development Uppsala University/Region Gävleborg Gävle Sweden.

Contrast-enhanced echocardiography or cardiac magnetic resonance imaging is of value in the diagnosis of apical hypertrophic cardiomyopathy. Apical hypertrophic cardiomyopathy is rare in Caucasians, and gene negativity does not rule out the diagnosis. Risk stratification for sudden cardiac death and decisions about anticoagulation in cases with atrial fibrillation should be based on guidelines. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2104
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http://dx.doi.org/10.1002/ccr3.2104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452448PMC
April 2019
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Relationship between changes in resting-state spontaneous brain activity and cognitive impairment in patients with CADASIL.

J Headache Pain 2019 Apr 17;20(1):36. Epub 2019 Apr 17.

Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People's Republic of China.

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) mainly manifests with cognitive impairment. Cognitive deficits in patients with CADASIL are correlated with structural brain changes such as lacunar lesion burden, normalized brain volume, and anterior thalamic radiation lesions, but changes in resting-state functional brain activity in patients with CADASIL have not been reported.

Methods: This study used resting-state functional magnetic resonance imaging (fMRI) to measure the amplitude of low-frequency fluctuation (ALFF) in 22 patients with CADASIL and 44 healthy matched controls. Read More

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http://dx.doi.org/10.1186/s10194-019-0982-3DOI Listing

The Clinical and Vascular Characteristics of RNF213 c.14576G>A Variant-Related Intracranial Major Artery Disease in China.

Behav Neurol 2019 12;2019:7908392. Epub 2019 Mar 12.

Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Background And Purpose: Recently, several studies indicated the c.14576G>A variant on the ring finger protein 213 (RNF213), a founder variant of moyamoya diseases (MMD), was associated with non-MMD intracranial major artery stenosis/occlusion (non-MMD ICASO). We proposed that RNF213 variant-related ICASO including MMD might be a special entity with its own characteristics based on a genetic background. Read More

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https://www.hindawi.com/journals/bn/2019/7908392/
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http://dx.doi.org/10.1155/2019/7908392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434291PMC
March 2019
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Axillary artery cannulation reduces early embolic stroke and mortality after open arch repair with circulatory arrest.

J Thorac Cardiovasc Surg 2019 Mar 15. Epub 2019 Mar 15.

Division of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

Objective: To evaluate the efficacy of axillary artery cannulation for early embolic stroke and operative mortality, we retrospectively compared the outcomes between patients with or without axillary artery cannulation during open aortic arch repair with circulatory arrest.

Methods: Between January 2004 and December 2017, 468 patients underwent open aortic arch repair with circulatory arrest using antegrade cerebral perfusion and were divided into 2 groups according to the site of arterial cannulation: the axillary artery (axillary group, n = 352) or another site (nonaxillary group, n = 116) groups. Embolic stroke was defined as a physician-diagnosed new postoperative neurologic deficit lasting more than 72 hours, generally confirmed by computed tomography or magnetic resonance imaging. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.02.112DOI Listing
March 2019
2 Reads

Right ventricular remodeling after conduit replacement in patients with corrected tetralogy of Fallot - evaluation by cardiac magnetic resonance.

J Cardiothorac Surg 2019 Apr 15;14(1):77. Epub 2019 Apr 15.

Department of Cardiothoracic Surgery, Clinical sciences, Lund University, Skane University Hospital, SE-221 85, Lund, Sweden.

Purpose: To evaluate the potential for right ventricular reverse remodelling after pulmonary valve replacement using cardiac magnetic resonance imaging, in adults with corrected tetralogy of Fallot and severe pulmonary insufficiency.

Material And Methods: Ten patients with previous correction of tetralogy of Fallot with severe pulmonary insufficiency accepted for pulmonary valve replacement were evaluated prospectively with cardiac magnetic resonance imaging preoperatively and re-evaluated 10 ± 5 months postoperatively. Follow up for survival was 100% complete with mean of 37 ± 12 months. Read More

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http://dx.doi.org/10.1186/s13019-019-0899-6DOI Listing
April 2019
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IMM-H004 Protects against Cerebral Ischemia Injury and Cardiopulmonary Complications via CKLF1 Mediated Inflammation Pathway in Adult and Aged Rats.

Int J Mol Sci 2019 Apr 3;20(7). Epub 2019 Apr 3.

Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces & College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

(1) Background: Chemokine-like factor 1 (CKLF1) is a chemokine with potential to be a target for stroke therapy. Compound IMM-H004 is a novel coumarin derivative screened from a CKLF1/C-C chemokine receptor type 4 (CCR4) system and has been reported to improve cerebral ischemia/reperfusion injury. This study aims to investigate the protective effects of IMM-H004 on cerebral ischemia injury and its infectious cardiopulmonary complications in adult and aged rats from the CKLF1 perspective. Read More

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http://dx.doi.org/10.3390/ijms20071661DOI Listing
April 2019
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Double-wavelet transform for multisubject task-induced functional magnetic resonance imaging data.

Biometrics 2019 Apr 15. Epub 2019 Apr 15.

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.

The goal of this article is to model multisubject task-induced functional magnetic resonance imaging (fMRI) response among predefined regions of interest (ROIs) of the human brain. Conventional approaches to fMRI analysis only take into account temporal correlations, but do not rigorously model the underlying spatial correlation due to the complexity of estimating and inverting the high dimensional spatio-temporal covariance matrix. Other spatio-temporal model approaches estimate the covariance matrix with the assumption of stationary time series, which is not always feasible. Read More

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http://dx.doi.org/10.1111/biom.13055DOI Listing

Assessment of cerebral infarction after transient cerebral ischemic attack by ABCD2 score combined with the position of intracranial vascular stenosis.

Medicine (Baltimore) 2019 Apr;98(15):e15081

This study aims to investigate the value of the ABCD score combined with the position of the offending vessel stenosis in predicting the risk of transient ischemic attack (TIA) to develop into cerebral infarction.The ABCD score and head magnetic resonance imaging + magnetic resonance angiography (MRA) results of 192 patients with TIA were retrospectively analyzed. With the 7th day as the endpoint time, these patients were divided into 3 groups, according to ABCD scores: low-risk group (n = 105), moderate-risk group (n = 60), and high-risk group (n = 27). Read More

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http://dx.doi.org/10.1097/MD.0000000000015081DOI Listing

Pretreatment Blood Pressure is a Simple Predictor of Hemorrhagic Infarction after Intravenous Recombinant Tissue Plasminogen Activator (rt-PA) Therapy.

J Stroke Cerebrovasc Dis 2019 Apr 11. Epub 2019 Apr 11.

Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Fukakusa, Kyoto, Japan.

Background: Hemorrhagic infarction (HI) is among the most severe complications that can occur following the administration of intravenous recombinant tissue plasminogen activator (rt-PA). In the present study, we aimed to determine the optimal cut-off points of blood pressure (BP) for HI after rt-PA treatment, and to compare our findings with those for other prediction models.

Methods: We analyzed data from 109 consecutive patients with stroke treated at our hospital between 2009 and 2016. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.035DOI Listing

Intracranial arterial wall imaging: Techniques, clinical applicability, and future perspectives.

Int J Stroke 2019 Apr 13:1747493019840942. Epub 2019 Apr 13.

4 Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, the Netherlands.

Purpose: To review the current state of the art and future development of intracranial vessel wall imaging.

Methods: Recent literature review and expert opinion about intracranial arterial wall imaging.

Results: Intracranial large artery diseases represent an important cause of stroke and vascular cognitive impairment worldwide. Read More

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http://dx.doi.org/10.1177/1747493019840942DOI Listing
April 2019
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Occurrence of cerebral small vessel disease at diagnosis of MPO-ANCA-associated vasculitis.

J Neurol 2019 Apr 13. Epub 2019 Apr 13.

Division of Neurology, Department of Internal Medicine IV, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.

Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) often causes peripheral nervous system impairments. However, little is known about subclinical involvements of the central nervous system in AAV. We investigated the frequency and progression of cerebral small vessel disease (SVD) in patients with AAV. Read More

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http://dx.doi.org/10.1007/s00415-019-09318-9DOI Listing

Anticoagulation therapy and the risk of perioperative brain injury in neonates with congenital heart disease.

J Thorac Cardiovasc Surg 2019 Feb 26. Epub 2019 Feb 26.

Division of Neurology, Department of Pediatrics, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada. Electronic address:

Objective: There is considerable variability in anticoagulation use in neonates with transposition of the great arteries (TGA) and single ventricle physiology (SVP) for secondary stroke prevention and primary cardiovascular indications. Leveraging cross-center differences in anticoagulation use, we compared the risk of new postoperative brain injury in neonates with TGA and SVP treated with anticoagulation relative to untreated neonates.

Methods: Two-center observational cohort study of 118 term-born neonates with TGA (n = 83) and SVP (n = 35), undergoing cardiopulmonary bypass surgery and pre- and postoperative brain magnetic resonance imaging. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.02.029DOI Listing
February 2019
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Rationale and design of the randomized, controlled Early Valve Replacement Guided by Biomarkers of Left Ventricular Decompensation in Asymptomatic Patients with Severe Aortic Stenosis (EVOLVED) trial.

Am Heart J 2019 Mar 15;212:91-100. Epub 2019 Mar 15.

British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom. Electronic address:

Background: The optimal timing of aortic valve replacement in asymptomatic patients with aortic stenosis is uncertain. Replacement fibrosis, as assessed by midwall (nonischemic) late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging, is an irreversible marker of left ventricular decompensation in aortic stenosis. Once established, it progresses rapidly and is associated with poor long-term prognosis in a dose-dependent manner. Read More

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http://dx.doi.org/10.1016/j.ahj.2019.02.018DOI Listing
March 2019
1 Read

Transorbital alternating current stimulation modifies BOLD activity in healthy subjects and in a stroke patient with hemianopia: A 7 Tesla fMRI feasibility study.

Int J Psychophysiol 2019 Apr 9. Epub 2019 Apr 9.

Institute of Medical Psychology, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany; Department of Clinical Neurophysiology, University Medical Center Göttingen, Göttingen, Germany.

Background: Modifying brain activity using non-invasive, low intensity transcranial electrical brain stimulation (TES) has rapidly increased during the past 20 years. Alternating current stimulation (ACS), for example, has been shown to alter brain rhythm activities and modify neuronal functioning in the visual system. Daily application transorbital ACS to patients with optic nerve damage induces functional connectivity reorganization, and partially restores vision. Read More

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http://dx.doi.org/10.1016/j.ijpsycho.2019.04.002DOI Listing
April 2019
3 Reads

Left Ventricular and Proximal Aorta Coupling in Magnetic Resonance Imaging: Aging Together?

Am J Physiol Heart Circ Physiol 2019 Apr 12. Epub 2019 Apr 12.

Division of cardiology, Johns Hopkins University, School of Medicine.

Background: The importance of aorta-ventricular coupling in cardiovascular disease is recognized but underestimated. The contribution of the age-related decline in ascending aortic function in comparison to characteristic impedance and total peripheral resistance on left ventricular function and remodeling is poorly studied. Our aim was to evaluate the relation of proximal aortic distensibility and impedance with left ventricular geometry and function in asymptomatic individuals. Read More

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http://dx.doi.org/10.1152/ajpheart.00694.2018DOI Listing
April 2019
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Uninterrupted edoxaban vs. vitamin K antagonists for ablation of atrial fibrillation: the ELIMINATE-AF trial.

Eur Heart J 2019 Apr 11. Epub 2019 Apr 11.

Department of Cardiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic.

Aims: Edoxaban is a direct factor Xa inhibitor approved for stroke prevention in atrial fibrillation (AF). Uninterrupted edoxaban therapy in patients undergoing AF ablation has not been tested.

Methods And Results: The ELIMINATE-AF trial, a multinational, multicentre, randomized, open-label, parallel-group study, was conducted to assess the safety and efficacy of once-daily edoxaban 60 mg (30 mg in patients indicated for dose reduction) vs. Read More

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http://dx.doi.org/10.1093/eurheartj/ehz190DOI Listing
April 2019
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Autopsied case with MERRF/MELAS overlap syndrome accompanied by stroke-like episodes localized to the precentral gyrus.

Neuropathology 2019 Apr 10. Epub 2019 Apr 10.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

We present an autopsied case with A8344G-mutated myoclonus epilepsy with ragged red fibers (MERRF)/mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) overlap syndrome accompanied by stroke-like episodes localized to the precentral gyrus. A 16-year-old Japanese woman suddenly experienced repetitive consciousness disturbances with increased serum lactate and creatine kinase levels. Magnetic resonance imaging showed abnormal intensity of bilateral precentral gyrus. Read More

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http://dx.doi.org/10.1111/neup.12551DOI Listing
April 2019
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Six-Month Outcome of Transient Ischemic Attack and Its Mimics.

Front Neurol 2019 27;10:294. Epub 2019 Mar 27.

Department of Neurology, Geisinger Medical Center, Danville, PA, United States.

Although the risk of recurrent cerebral ischemia is higher after a transient ischemic attack (TIA), there is limited data on the outcome of TIA mimics. The goal of this study is to compare the 6-month outcome of patients with negative and positive diffusion-weighted imaging (DWI) TIAs (DWI-neg TIA vs. DWI-pos TIA) and also TIA mimics. Read More

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http://dx.doi.org/10.3389/fneur.2019.00294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445867PMC
March 2019
4 Reads

Postoperative ischemic events in patients undergoing carotid artery stenting using algorithmic selection for embolic protection.

Neuroradiol J 2019 Apr 11:1971400919839644. Epub 2019 Apr 11.

2 Department of Neurosurgery, National Hospital Organization Kyoto Medical Center, Japan.

Purpose: Carotid artery stenting (CAS) is a valuable alternative to carotid endarterectomy, especially in high-risk patients. However, the reported incidences of perioperative stroke and death remain higher than for carotid endarterectomy, even when using embolic protection devices (EPDs) during CAS. Our purpose was to evaluate 30-day major adverse events after CAS when selecting the most appropriate EPD. Read More

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http://dx.doi.org/10.1177/1971400919839644DOI Listing
April 2019
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Symptomatic Carotid Plaques Demonstrate Less Leaky Plaque Microvasculature Compared With the Contralateral Side: A Dynamic Contrast-Enhanced Magnetic Resonance Imaging Study.

J Am Heart Assoc 2019 Apr;8(8):e011832

1 Department of Radiology and Nuclear Medicine Maastricht University Medical Centre Maastricht The Netherlands.

Background Rupture of a vulnerable carotid atherosclerotic plaque is an important underlying cause of ischemic stroke. Increased leaky plaque microvasculature may contribute to plaque vulnerability. These immature microvessels may facilitate entrance of inflammatory cells into the plaque. Read More

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http://dx.doi.org/10.1161/JAHA.118.011832DOI Listing
April 2019
1 Read

Synergistic role of susceptibility-weighted imaging with diffusion-weighted imaging and magnetic resonance angiography in the evaluation of acute arterial stroke.

J Int Med Res 2019 Apr 10:300060519840909. Epub 2019 Apr 10.

3 Department of Internal Medicine, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Objective: This study was performed to investigate whether diffusion-weighted imaging (DWI) and susceptibility-weighted imaging (SWI) are more effective than conventional imaging modalities for evaluation of stroke and selection of candidates for thrombolytic therapy.

Methods: Eighty patients who presented within 12 hours of onset of symptoms of brain ischemia underwent 1.5T magnetic resonance imaging. Read More

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http://dx.doi.org/10.1177/0300060519840909DOI Listing
April 2019
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Post-Stroke Blood-Brain Barrier Disruption and Poor Functional Outcome in Patients Receiving Thrombolytic Therapy.

Cerebrovasc Dis 2019 Apr 10:1-8. Epub 2019 Apr 10.

National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA,

Background And Purpose: The role played by post-stroke inflammation after an ischemic event in limiting functional recovery remains unclear. One component of post-stroke inflammation is disruption of the blood-brain barrier (BBB). This study examines the relationship between post-stroke BBB disruption and functional outcome. Read More

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http://dx.doi.org/10.1159/000499666DOI Listing
April 2019
2 Reads

Cardiovascular effects of two adenosine constant rate infusions in anaesthetized dogs.

Vet Anaesth Analg 2019 Feb 8. Epub 2019 Feb 8.

Department of Clinical Diagnostics and Services, Division of Anaesthesiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Objective: Adenosine induces vasodilatation. The aim of this study was to investigate cardiovascular effects of two adenosine constant rate infusion (CRI) doses in dogs.

Study Design: Experimental, longitudinal repeated measure design. Read More

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http://dx.doi.org/10.1016/j.vaa.2018.12.007DOI Listing
February 2019

Survival of retinal ganglion cells after damage to the occipital lobe in humans is activity dependent.

Proc Biol Sci 2019 Feb;286(1897):20182733

3 Department of Psychology, Carnegie Mellon University , Pittsburgh, PA 15206 , USA.

Damage to the optic radiations or primary visual cortex leads to blindness in all or part of the contralesional visual field. Such damage disconnects the retina from its downstream targets and, over time, leads to trans-synaptic retrograde degeneration of retinal ganglion cells. To date, visual ability is the only predictor of retinal ganglion cell degeneration that has been investigated after geniculostriate damage. Read More

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http://dx.doi.org/10.1098/rspb.2018.2733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408898PMC
February 2019
1 Read

Distilling the essence of TMS-evoked EEG potentials (TEPs): A call for securing mechanistic specificity and experimental rigor.

Brain Stimul 2019 Apr 2. Epub 2019 Apr 2.

Deutsches Resilienz Zentrum (DRZ), Johannes Gutenberg University Medical Center, Mainz, Germany; Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard Karls University of Tübingen, Tübingen, Germany; Institute for Medical Psychology and Behavioral Neurobiology, Eberhard Karls University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1016/j.brs.2019.03.076DOI Listing

Craniocervical Arterial Dissection in Children: Pathophysiology and Management.

Pediatr Neurol 2019 Feb 2. Epub 2019 Feb 2.

Section of Pediatric Neurology, Department of Pediatrics and Child Health, University of Manitoba, Manitoba, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Background: Craniocervical arterial dissection is a commonly reported arteriopathy associated with stroke in children. It is characterized by a high stroke recurrence rate and variable outcomes. Here we review the pathophysiology, clinical presentation, and diagnostic neuroimaging approaches that are helpful in accurate diagnosis and follow-up of children with arterial dissection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183130
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http://dx.doi.org/10.1016/j.pediatrneurol.2019.01.020DOI Listing
February 2019
3 Reads

Clinical feasibility of brain quantitative susceptibility mapping.

Magn Reson Imaging 2019 Apr 4;60:44-51. Epub 2019 Apr 4.

Department of Radiology, Weill Cornell Medicine, New York, NY, USA; Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA. Electronic address:

Purpose: To evaluate the quality of brain quantitative susceptibility mapping (QSM) that is fully automatically reconstructed in clinical MRI of various neurological diseases.

Methods: 393 consecutive patients in one month were recruited for this evaluation study. QSM was reconstructed using Morphology Enabled Dipole Inversion without zero reference regularization (MEDI) and using MEDI with cerebrospinal fluid automatic zero-reference regularization to generate susceptibility values (MEDI+0). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0730725X193001
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http://dx.doi.org/10.1016/j.mri.2019.04.003DOI Listing
April 2019
4 Reads

Carotid artery imaging: the study of intra-plaque vascularization and hemorrhage in the era of the "vulnerable" plaque.

J Neuroradiol 2019 Apr 4. Epub 2019 Apr 4.

Department of Medical Imaging, AOU of Cagliari, University of Cagliari, Italy.

Intraplaque hemorrhage (IPH) is one of the main factors involved in atherosclerotic plaque (AP) instability. Its recognition is crucial for the correct staging and management of patients with carotid artery plaques to limit ischemic stroke. Imaging plays a crucial role in identifying IPH, even if the great variability of intraplaque vascularization and the limitations of our current imaging technologies make it difficult. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01509861183031
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http://dx.doi.org/10.1016/j.neurad.2019.03.009DOI Listing
April 2019
7 Reads

A closer look at right ventricular 3D volume quantification by transthoracic echocardiography and cardiac MRI.

Clin Radiol 2019 Apr 4. Epub 2019 Apr 4.

Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Germany.

Aim: To compare right ventricular (RV) volumetry using state-of-the-art three-dimensional (3D) transthoracic echocardiography (3DE) and cardiac magnetic resonance imaging (CMR) near-simultaneously in a clinical setting.

Materials And Methods: Forty-seven consecutive patients received comprehensive echocardiography including 3DE within 30 minutes of CMR. RV volumetry was performed offline with semi-automated 3D endocardial border tracing as well as manual delineation of the compacted myocardium in short-axis views by CMR. Read More

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http://dx.doi.org/10.1016/j.crad.2019.03.005DOI Listing

Multimodality imaging of left atrium in patients with atrial fibrillation.

J Cardiovasc Comput Tomogr 2019 Mar 30. Epub 2019 Mar 30.

Centro Cardiologico Monzino, IRCCS, Milan, Italy. Electronic address:

Atrial fibrillation (AF) is the most common arrhythmia worldwide associated with significant morbidity and mortality and represents a significant health care burden. Goals of AF treatment include prevention of cardioembolic stroke using anticoagulation and device therapy and restoration of sinus rhythm using antiarrhythmic drugs or catheter ablation techniques. A comprehensive assessment of cardiac chamber size and function is often started with echocardiography as a first line diagnostic imaging strategy. Read More

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http://dx.doi.org/10.1016/j.jcct.2019.03.005DOI Listing
March 2019
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Novel gap junction protein beta-1 gene mutation associated with a stroke-like syndrome and central nervous system involvement in patients with X-linked Charcot-Marie-Tooth Type 1: A case report and literature review.

Clin Neurol Neurosurg 2019 May 28;180:68-73. Epub 2019 Mar 28.

Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, China. Electronic address:

Gap junction protein beta-1 (GJB1) gene mutations lead to X-linked Charcot-Marie-Tooth Type 1 (CMTX1). We studied a Chinese family with CMTX1 and identified a novel GJB1 point mutation. Our patient had a transient stroke-like clinical manifestations and magnetic resonance imaging (MRI) changes. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.03.018DOI Listing

MRI Assessment of Oxygen Metabolism and Hemodynamic Status in Symptomatic Intracranial Atherosclerotic Stenosis: A Pilot Study.

J Neuroimaging 2019 Apr 4. Epub 2019 Apr 4.

Department of Neuroradiology, Hospices Civils de Lyon, Bron, France.

Background And Purpose: Hemodynamic and metabolic impairment in intracranial atherosclerotic stenosis (ICAS) may promote stroke vulnerability particularly in borderzone areas. Perfusion and oxygen mapping magnetic resonance imaging (MRI) may provide useful information in this setting.

Methods: In this pilot study, patients with symptomatic atherosclerotic anterior circulation stenosis ≥60%, without other sources of ischemic stroke, were included. Read More

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http://dx.doi.org/10.1111/jon.12615DOI Listing
April 2019
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New Variant of MELAS Syndrome With Executive Dysfunction, Heteroplasmic Point Mutation in the Gene (m.12015T>C; p.Leu419Pro) and Comorbid Polyglandular Autoimmune Syndrome Type 2.

Front Immunol 2019 21;10:412. Epub 2019 Mar 21.

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Mitochondrial diseases are caused by dysfunctions in mitochondrial metabolic pathways. MELAS syndrome is one of the most frequent mitochondrial disorders; it is characterized by encephalopathy, myopathy, lactic acidosis, and stroke-like episodes. Typically, it is associated with a point mutation with an adenine-to-guanine transition at position 3243 of the mitochondrial DNA (mtDNA; m. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437310PMC
March 2019
2 Reads

Extracranial Artery Stenosis Is Associated With Total MRI Burden of Cerebral Small Vessel Disease in Ischemic Stroke Patients of Suspected Small or Large Artery Origins.

Front Neurol 2019 21;10:243. Epub 2019 Mar 21.

Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Extracranial artery stenosis (ECAS) is related to individual imaging markers of cerebral small vessel disease (cSVD). However, little has been reported on the association between ECAS and the total burden of cSVD as assessed by magnetic resonance imaging (MRI). The purpose of this study was to investigate the relationship between ECAS and cSVD burden in patients with ischemic stroke of suspected small or large artery origin. Read More

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http://dx.doi.org/10.3389/fneur.2019.00243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437037PMC
March 2019
1 Read

Sickle Cell Disease and Stroke.

Pediatr Neurol 2019 Feb 27. Epub 2019 Feb 27.

Developmental Neurosciences Section and Biomedical Research Unit, Clinical and Experimental Sciences, University of Southampton, UCL Great Ormond Street Institute of Child Health, London, UK. Electronic address:

Cerebral infarction is a common complication of sickle cell disease and may manifest as overt stroke or cognitive impairment associated with "silent" cerebral infarction on magnetic resonance imaging. Vasculopathy may be diagnosed on transcranial Doppler or magnetic resonance angiography. The risk factors in sickle cell disease for cognitive impairment, overt ischemic stroke, silent cerebral infarction, overt hemorrhagic stroke, and vasculopathy defined by transcranial Doppler or magnetic resonance angiography overlap, with severe acute and chronic anemia, acute chest crisis, reticulocytosis, and low oxygen saturation reported with the majority. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183130
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http://dx.doi.org/10.1016/j.pediatrneurol.2019.02.018DOI Listing
February 2019
2 Reads

Extending the time window for intravenous thrombolysis in acute ischemic stroke using magnetic resonance imaging-based patient selection.

Int J Stroke 2019 Apr 4:1747493019840938. Epub 2019 Apr 4.

16 Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.

Background: Intravenous thrombolysis with alteplase within a time window up to 4.5 h is the only approved pharmacological treatment for acute ischemic stroke. We studied whether acute ischemic stroke patients with penumbral tissue identified on magnetic resonance imaging 4. Read More

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http://dx.doi.org/10.1177/1747493019840938DOI Listing
April 2019
3 Reads

Outcome, efficacy and safety of endovascular thrombectomy in ischaemic stroke according to time to reperfusion: data from a multicentre registry.

Ther Adv Neurol Disord 2019 27;12:1756286419835708. Epub 2019 Mar 27.

Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Freiburgstrasse 8, CH-3010, Switzerland.

Background And Purpose: In acute ischaemic stroke (AIS) of the anterior circulation (AC) treated with mechanical thrombectomy (MT), data point to a decline of treatment effect with increasing time from symptom onset to treatment. However, the magnitude of the decline will depend on the clinical setting and imaging selection used. The aims of this study were (1) to evaluate the clinical effect of time to reperfusion (TTR); and (2) to assess the safety and technical efficacy of MT according to strata of TTR. Read More

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http://dx.doi.org/10.1177/1756286419835708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437320PMC
March 2019
3 Reads

Repeatability and reproducibility of cerebral Na imaging in healthy subjects.

BMC Med Imaging 2019 04 3;19(1):26. Epub 2019 Apr 3.

Institute of Diagnostic and Interventional Radiology, University Hospital Cologne, University of Cologne, Cologne, Germany.

Background: Initial reports of Na magnetic resonance imaging (MRI) date back to the 1970s. However, methodological challenges of the technique hampered its widespread adoption for many years. Recent technical developments have overcome some of these limitations and have led to more optimal conditions for Na-MR imaging. Read More

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https://bmcmedimaging.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12880-019-0324-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446283PMC
April 2019
5 Reads