33,499 results match your criteria Magnetic Resonance Imaging in Acute Stroke


Direct Oral Anticoagulants After Percutaneous Patent Foramen Ovale (PFO) Closure: A Call for Caution.

Am J Case Rep 2020 Jul 6;21:e922467. Epub 2020 Jul 6.

Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.

BACKGROUND Transient atrial fibrillation (AF) following percutaneous patent foramen ovale (PFO) closure is common. Anticoagulation therapy should be considered in selected cases of prolonged AF after PFO closure, but guidelines do not provide clear recommendations on indication or choice of anticoagulant therapy for patients with post-procedural AF. CASE REPORT A 45-year-old woman presented with cryptogenic stroke verified by magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.12659/AJCR.922467DOI Listing

Predictors of malignant middle cerebral artery infarction after mechanical thrombectomy.

Rev Neurol (Paris) 2020 Jul 2. Epub 2020 Jul 2.

Neurosurgery, university hospital, Rennes, France.

Introduction: Several predictors have been described to early diagnose malignant middle cerebral artery infarction (MMI) and select patient for hemicraniectomy. Nevertheless, few studies have assessed them among patients with acute ischemic stroke undergoing mechanical endovascular thrombectomy (MET). The overall objective in this study was to evaluate these predictors in patients undergoing MET in the purpose to guide the medical care in the acute phase. Read More

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http://dx.doi.org/10.1016/j.neurol.2020.01.352DOI Listing

Intramural Hematoma Shape and Acute Cerebral Infarction in Intracranial Artery Dissection: A High-Resolution Magnetic Resonance Imaging Study.

Cerebrovasc Dis 2020 Jul 3:1-8. Epub 2020 Jul 3.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea,

Background: Intracranial artery dissection (IAD) is gaining recognition as an important cause of stroke, but limited information is available about the morphology of the dissection. This study aimed to investigate the relationship between acute cerebral infarctions and the shape of hematoma in patients with IADs using high-resolution magnetic resonance imaging (HRMRI).

Methods: We enrolled consecutive patients who presented with vascular headaches, transient ischemic attacks, or ischemic strokes with acute IAD confirmed by HRMRI using key pathognomonic radiological findings of IAD, including intimal flap, intramural hematoma (IMH), and double lumen. Read More

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http://dx.doi.org/10.1159/000508027DOI Listing

Thoracoscopic Left Atrial Appendage Excision plus Ablation for Atrial Fibrillation to Prevent Stroke.

Semin Thorac Cardiovasc Surg 2020 Jul 2. Epub 2020 Jul 2.

Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. Electronic address:

Atrial fibrillation (AF) patients with a previous stroke are often at a high risk of recurrent stroke and bleeding. Anticoagulation therapy in such patients is a challenging dilemma. Thoracoscopic left atrial appendage excision (LAAE) plus AF ablation is an interventional approach offered to some AF patients. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2020.06.041DOI Listing

Motor evoked potentials during revascularization in ischemic stroke predict motor pathway ischemia and clinical outcome.

Clin Neurophysiol 2020 Jun 18. Epub 2020 Jun 18.

Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Objective: The relevance of motor evoked potential (MEP) recovery during mechanical endovascular thrombectomy (MT) in patients with ischemic stroke is unclear. We correlated MEP recovery during MT to symptom improvement and to ischemia in eloquent motor areas on magnetic resonance imaging (MRI) and compared the predictive value of MEPs to visual angiographic reperfusion status, classified by modified Thrombolysis in Cerebral Infarction grading (mTICI).

Methods: Patients with hemisyndrome and large-vessel occlusion undergoing MT were included (n35, 49% females; 73. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.05.026DOI Listing

Identification of neural networks preferentially engaged by epileptogenic mass lesions through lesion network mapping analysis.

Sci Rep 2020 Jul 3;10(1):10989. Epub 2020 Jul 3.

Division of Neurosurgery, University Health Network, Toronto, ON, USA.

Lesion network mapping (LNM) has been applied to true lesions (e.g., cerebrovascular lesions in stroke) to identify functionally connected brain networks. Read More

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http://dx.doi.org/10.1038/s41598-020-67626-xDOI Listing

High-Degree Middle Cerebral Artery Stenosis : Can Advanced 3D DSA-MRI Fusion Imaging Better Illustrate Plaques and Perforators?

Clin Neuroradiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurology, The First Affiliated Hospital, Jinan University, NO.613 the West of Huangpu street, 510630, Guangzhou, China.

Purpose: Endovascular treatment in severe middle cerebral artery (MCA) stenosis is controversial owing to high rates of periprocedural complications, especially occlusion of the lenticulostriate arteries (LSA). The characteristics of LSAs and the spatial relationships between MCA plaques and LSAs using the fusion of three-dimensional (3D) digital subtraction angiography (DSA) and magnetic resonance imaging (3D DSA-MRI fusion) were investigated.

Methods: We retrospectively analyzed data from 32 ischemic stroke or transient ischemic attack patients with severe MCA stenosis, who underwent MRI and DSA within 2 weeks after symptom onset. Read More

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http://dx.doi.org/10.1007/s00062-020-00927-wDOI Listing

Intranasal salvinorin A improves neurological outcome in rhesus monkey ischemic stroke model using autologous blood clot.

J Cereb Blood Flow Metab 2020 Jul 2:271678X20938137. Epub 2020 Jul 2.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Salvinorin A (SA) exerts neuroprotection and improves neurological outcomes in ischemic stroke models in rodents. In this study, we investigated whether intranasal SA administration could improve neurological outcomes in a monkey ischemic stroke model. The stroke model was induced in adult male rhesus monkeys by occluding the middle cerebral artery M2 segment with an autologous blood clot. Read More

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http://dx.doi.org/10.1177/0271678X20938137DOI Listing

Enhanced white matter reorganization and activated brain glucose metabolism by enriched environment following ischemic stroke: Micro PET/CT and MRI study.

Neuropharmacology 2020 Jun 29:108202. Epub 2020 Jun 29.

School of Traditional Chinese Medicine, Capital Medical University, Beijing, China; Beijing Key Lab of TCM Collateral Disease Theory Research, Beijing, China. Electronic address:

Enriched environment (EE) is an effective rehabilitative protocol designed to enhance sensorimotor, cognitive and social stimulation. Current understanding of neuronal remodeling after EE intervention mainly derived from conventional histological methods. The efficacy of EE treatment on post-stroke brain reorganization still needed to be elucidated in vivo. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2020.108202DOI Listing

-----Comparison of T1-Post and FLAIR-Post MRI for identification of traumatic meningeal enhancement in traumatic brain injury patients.

PLoS One 2020 2;15(7):e0234881. Epub 2020 Jul 2.

National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America.

Traumatic meningeal enhancement (TME) is a novel biomarker observed on post-contrast fluid-attenuated inversion recovery (FLAIR) in patients who undergo contrast-enhanced magnetic resonance imaging (MRI) after suspected traumatic brain injury (TBI). TME may be seen on acute MRI despite the absence of other trauma-related intracranial findings. In this study we compare conspicuity of TME on FLAIR post-contrast and T1 weighted imaging (T1WI) post-contrast, and investigate if TME is best detected by FLAIR post-contrast or T1WI post-contrast sequences. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234881PLOS

Physiological changes in sleep that affect fMRI inference.

Curr Opin Behav Sci 2020 Jun 23;33:42-50. Epub 2019 Dec 23.

Advanced Magnetic Resonance Imaging Section, National Institute of Neurological Disorders and Stroke.

fMRI relies on a localized cerebral blood flow (CBF) response to changes in cortical neuronal activity. An underappreciated aspect however is its sensitivity to contributions from autonomic physiology that may affect CBF through changes in vascular resistance and blood pressure. As is reviewed here, this is crucial to consider in fMRI studies of sleep, given the close linkage between the regulation of arousal state and autonomic physiology. Read More

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http://dx.doi.org/10.1016/j.cobeha.2019.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328858PMC

The Impact of Cerebral Microbleeds Presence on Outcome Following Minor Stroke Treated With Antiplatelet Therapy.

Front Neurol 2020 16;11:522. Epub 2020 Jun 16.

Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.

The relationship between cerebral microbleeds (CMBs) and prognosis in patients with ischemic stroke is still unclear. Our aim here was to verify the relationship between CMBs and functional outcomes in patients with minor ischemic stroke treated with antiplatelet therapy. We retrospectively reviewed consecutive patients with a non-cardiogenic minor ischemic stroke (NIHSS <4 on admission) who underwent initial brain magnetic resonance imaging within the first 48 h following symptom onset. Read More

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http://dx.doi.org/10.3389/fneur.2020.00522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308486PMC

Biventricular imaging markers to predict outcomes in non-compaction cardiomyopathy: a machine learning study.

ESC Heart Fail 2020 Jun 30. Epub 2020 Jun 30.

Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, São Paulo, 05403-000, Brazil.

Aims: Left ventricular non-compaction cardiomyopathy (LVNC) is a genetic heart disease, with heart failure, arrhythmias, and embolic events as main clinical manifestations. The goal of this study was to analyse a large set of echocardiographic (echo) and cardiac magnetic resonance imaging (CMRI) parameters using machine learning (ML) techniques to find imaging predictors of clinical outcomes in a long-term follow-up of LVNC patients.

Methods And Results: Patients with echo and/or CMRI criteria of LVNC, followed from January 2011 to December 2017 in the heart failure section of a tertiary referral cardiologic hospital, were enrolled in a retrospective study. Read More

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http://dx.doi.org/10.1002/ehf2.12795DOI Listing

Cardiac Imaging After Ischemic Stroke or Transient Ischemic Attack.

Curr Neurol Neurosci Rep 2020 Jun 30;20(8):36. Epub 2020 Jun 30.

Clinic for Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.

Purpose Of Review: Cardiac imaging after ischemic stroke or transient ischemic attack (TIA) is used to identify potential sources of cardioembolism, to classify stroke etiology leading to changes in secondary stroke prevention, and to detect frequent comorbidities. This article summarizes the latest research on this topic and provides an approach to clinical practice to use cardiac imaging after stroke.

Recent Findings: Echocardiography remains the primary imaging method for cardiac work-up after stroke. Read More

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http://dx.doi.org/10.1007/s11910-020-01053-3DOI Listing

Decompression illness type II with stroke: challenging situation in acute neurorehabilitation.

Int Marit Health 2020 ;71(2):105-108

Department of Neurorehabilitation, Leicester General Hospital, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.

A professional 55-year-old female experienced diver, who surfaced after the second dive, had a lucid interval before dropping Glasgow Coma Scale (GCS) to 3/15. She was admitted to intensive care unit and commenced on hyperbaric oxygen therapy. Her initial computed tomography of the head was normal but her magnetic resonance imaging of the brain at 48 hours showed extensive bilateral cortical watershed territory infarcts. Read More

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http://dx.doi.org/10.5603/IMH.2020.0019DOI Listing
January 2020

Inversion Recovery Susceptibility Weighted Imaging With Enhanced T2 Weighting at 3 T Improves Visualization of Subpial Cortical Multiple Sclerosis Lesions.

Invest Radiol 2020 Jun 22. Epub 2020 Jun 22.

From the Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke.

Objectives: Cortical demyelination is common in multiple sclerosis (MS) and can be extensive. Cortical lesions contribute to disability independently from white matter lesions and may form via a distinct mechanism. However, current magnetic resonance imaging methods at 3 T are insensitive to cortical, and especially subpial cortical, lesions. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000698DOI Listing

Diagnosis of Neural Deterioration in Patients with Cerebral Infarction Combined with Non-valvular Atrial Fibrillation under Magnetic Resonance Imaging and Exploration of the Prognostic Infection Factors.

Neurosci Lett 2020 Jun 27:135213. Epub 2020 Jun 27.

Department of Emergency, Geriatric Hospital of Nanjing Medical University, Nanjing City, 210024, China.

To study the prognosis and risk factors of neural deterioration in patients with acute cerebral infarction combined with nonvalvular atrial fibrillation (NVAF), a computer platform was constructed and relevant clinical analysis was conducted, and the basic framework of computer cerebrovascular disease database was established. According to the clinical data of 300 patients with cerebral infarction with NVAF, test results, and imaging data, the anticoagulation treatment, PT-INR monitoring, and the occurrence of healthcare-associated infection recorded in the computer database were tracked, and prognostic factors and infective factors were investigated and recorded. The results showed that among the 70 patients receiving warfarin anticoagulation therapy, there were significant differences in proportion of admission NIHSS score and massive infarction (P < 0. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135213DOI Listing

Unusual non-valvular left ventricular endocarditis presenting as multiple brain embolism.

Acta Clin Belg 2020 Jun 30:1-5. Epub 2020 Jun 30.

Faculty of Medicine, University of Novi Sad , Novi Sad, Serbia.

Introduction: Masses inside the heart can cause serious and life-threatening effects to the cardiovascular system, mainly because of hemodynamic obstruction of the blood flow, either in the heart cavities themselves or remotely due to embolization. In this paper, we report a case of left ventricular tumor mass which presented with neurological symptoms due to multiple brain embolism.

Case Report: A 35-year-old female patient presented with right hemiparesis and dysarthria. Read More

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http://dx.doi.org/10.1080/17843286.2020.1789273DOI Listing

Silent Cerebral Infarct in Sickle Cell Anemia Patients of South Turkey.

Turk J Med Sci 2020 Jun 30. Epub 2020 Jun 30.

Background/aim: Silent cerebral infarct (SCI) is an ischemic lesion seen before clinical signs of brain infarct and ischemic changes in brain tissue. This study aimed to detect SCI with non-invasive methods and to determine releated risk factors in patients with sickle cell anemia (SCA).

Materials And Methods: Fifty-four SCA patients who had no history of cerebral infarct and whose neurological examinations were normal, were included in this study. Read More

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http://dx.doi.org/10.3906/sag-2003-192DOI Listing

Oxygen extraction fraction mapping with multi-parametric quantitative BOLD MRI: reduced transverse relaxation bias using 3D-GraSE imaging.

Neuroimage 2020 Jun 26:117095. Epub 2020 Jun 26.

Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Diagnostic and Interventional Neuroradiology, Munich, Germany; Technical University of Munich, School of Medicine, Klinikum rechts der Isar, TUM Neuroimaging Center, Munich, Germany; Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Clinic for Neurology, Munich, Germany.

Magnetic resonance imaging (MRI)-based quantification of the blood-oxygenation-level-dependent (BOLD) effect allows oxygen extraction fraction (OEF) mapping. The multi-parametric quantitative BOLD (mq-BOLD) technique facilitates relative OEF (rOEF) measurements with whole brain coverage in clinically applicable scan times. Mq-BOLD requires three separate scans of cerebral blood volume and transverse relaxation rates measured by gradient-echo (1/T*) and spin-echo (1/T). Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117095DOI Listing

Use of Real-Time Functional Magnetic Resonance Imaging-Based Neurofeedback to Downregulate Insular Cortex in Nicotine-Addicted Smokers.

J Vis Exp 2020 Jun 10(160). Epub 2020 Jun 10.

Departamento de Psiquiatría, Escuela de Medicina, Centro Interdisciplinario de Neurociencias, Pontificia Universidad Católica de Chile; Laboratory for Brain-Machine Interfaces and Neuromodulation, Pontificia Universidad Católica de Chile; Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile;

It has been more than a decade since the first functional magnetic resonance imaging (fMRI)-based neurofeedback approach was successfully implemented. Since then, various studies have demonstrated that participants can learn to voluntarily control a circumscribed brain region. Consequently, real-time fMRI (rtfMRI) provided a novel opportunity to study modifications of behavior due to manipulation of brain activity. Read More

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http://dx.doi.org/10.3791/59441DOI Listing

Return to Sport After Arthroscopic Rotator Cuff Repair in Middle-Aged and Elderly Swimmers.

Orthop J Sports Med 2020 Jun 17;8(6):2325967120922203. Epub 2020 Jun 17.

Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

Background: No reports have been published on the clinical outcomes, including return to sport, after rotator cuff repair in middle-aged and elderly swimmers with rotator cuff tears.

Purpose: To retrospectively investigate clinical outcomes and return to sport after arthroscopic rotator cuff repair in middle-aged and elderly swimmers.

Study Design: Case series; Level of evidence, 4. Read More

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http://dx.doi.org/10.1177/2325967120922203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301663PMC

ACTA2 leukovasculopathy: A rare pediatric white matter disorder.

Radiol Case Rep 2020 Aug 18;15(8):1285-1288. Epub 2020 Jun 18.

University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390.

A 3-year-old girl presented with ataxia, dilated pupils, and behavioral change prompting work up for stroke. Her medical history included chronic mydriasis and patent ductus arteriosus requiring aortoplasty. Magnetic resonance imaging of the brain demonstrated confluent white matter signal abnormality concerning for leukodystrophy. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306539PMC

Fluctuations in Moyamoya Vasculopathy Associated with Basedow Disease Depending on Thyroid Hormone Status.

Case Rep Neurol 2020 May-Aug;12(2):140-147. Epub 2020 May 20.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

A 31-year-old woman presented with sudden onset of weakness in her left upper limb. Magnetic resonance imaging revealed acute cerebral infarctions in the right frontal and parietal lobes. Magnetic resonance angiography showed stenosis in the proximal portions of the bilateral middle cerebral arteries and terminal portions of the bilateral internal carotid arteries. Read More

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http://dx.doi.org/10.1159/000502571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315203PMC

A Machine Learning Approach for the Differential Diagnosis of Alzheimer and Vascular Dementia Fed by MRI Selected Features.

Front Neuroinform 2020 11;14:25. Epub 2020 Jun 11.

NMR Research Unit, Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Centre, UCL Queen Square Institute of Neurology, London, United Kingdom.

Among dementia-like diseases, Alzheimer disease (AD) and vascular dementia (VD) are two of the most frequent. AD and VD may share multiple neurological symptoms that may lead to controversial diagnoses when using conventional clinical and MRI criteria. Therefore, other approaches are needed to overcome this issue. Read More

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http://dx.doi.org/10.3389/fninf.2020.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300291PMC

Subsampled brain MRI reconstruction by generative adversarial neural networks.

Med Image Anal 2020 Jun 11;65:101747. Epub 2020 Jun 11.

The School of Electrical and Computer Engineering The Zlotowski Center for Neuroscience Ben-Gurion University of the Negev, Israel. Electronic address:

A main challenge in magnetic resonance imaging (MRI) is speeding up scan time. Beyond improving patient experience and reducing operational costs, faster scans are essential for time-sensitive imaging, such as fetal, cardiac, or functional MRI, where temporal resolution is important and target movement is unavoidable, yet must be reduced. Current MRI acquisition methods speed up scan time at the expense of lower spatial resolution and costlier hardware. Read More

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http://dx.doi.org/10.1016/j.media.2020.101747DOI Listing

Clinical characteristics and brain MRI findings in myeloproliferative neoplasms.

J Neurol Sci 2020 Jun 19;416:116990. Epub 2020 Jun 19.

Department of Neurology, Nippon Medical School, Tokyo, Japan.

Background: Myeloproliferative neoplasms (MPNs) including polycythemia vera (PV) and essential thrombocythemia (ET) have an increased risk of ischemic stroke. However, little is known about brain morphological changes and the cerebral vasculature in MPNs. The aim of the present study is to clarify the prevalence rates of brain infarcts (BIs) on magnetic resonance imaging (MRI) and to assess the detailed clinical and MRI characteristics in those patients. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116990DOI Listing

Physiologic effects and functional outcome after treatment of dysfunctional right ventricular outflow tract in congenital heart disease using a two-stage intervention.

Int J Cardiol 2020 Jun 25. Epub 2020 Jun 25.

Heart Center Leipzig at University Leipzig, Department of Internal Medicine/Cardiology, Germany. Electronic address:

Background Pathophysiological differences in relief of pulmonary stenosis (PS) as opposed to pulmonary regurgitation (PR) by percutaneous pulmonary valve implantation (PPVI) remain elusive, but might impact current assessment of procedural success and ultimately indications. Methods Invasive pressure measurements, cardiac magnetic resonance imaging and cardiopulmonary exercise testing were performed before pre-stenting (BMS), after BMS and after PPVI in patients with either PS or PR. Results In PS (n = 14), BMS reduced the right ventricular (RV) to systemic pressure ratio (0. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.026DOI Listing

A Case Report of Sporadic Adult Neuronal Intranuclear Inclusion Disease (NIID) With Stroke-Like Onset.

Front Neurol 2020 10;11:530. Epub 2020 Jun 10.

Department of Neurology, Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China.

Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease. The clinical manifestations of NIID are complex and easily misdiagnosed. Based on the current knowledge of this disease, it is usually chronic, with almost no acute cases. Read More

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http://dx.doi.org/10.3389/fneur.2020.00530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298109PMC

Patterns of motor recovery and structural neuroplasticity after striatal infarcts.

Neurology 2020 Jun 25. Epub 2020 Jun 25.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

Objective: To elucidate the timeframe and spatial patterns of cortical reorganization after different stroke-induced basal ganglia lesions, we measured cortical thickness at five timepoints over a six-month period. We hypothesized that cortical reorganization would occur very early and that, along with motor recovery, it would vary based on the stroke lesion site.

Methods: Thirty-three patients with unilateral basal ganglia stroke and 23 healthy control participants underwent MRI scanning and behavioral testing. Read More

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http://dx.doi.org/10.1212/WNL.0000000000010149DOI Listing

Ruptured Vertebral Artery Dissecting Aneurysm in a Patient with Recurrent Bacterial Meningitis.

World Neurosurg 2020 Jun 22. Epub 2020 Jun 22.

Department of Neurosurgery, University of Louisville, Louisville, KY.

Background: Intracranial mycotic aneurysms are uncommon, it can occur due extravascular extension or intravascular seeding of the vessel wall. It often results subarachnoid hemorrhage (SAH) with poor prognosis. We present a rare case of ruptured proximal anterior inferior cerebellar artery- posterior inferior cerebellar artery (AICA-PICA) mycotic aneurysm after an episode of bacterial meningitis. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.090DOI Listing

Direct oral anticoagulants compared to vitamin K antagonist for the management of left ventricular thrombus.

ESC Heart Fail 2020 Jun 25. Epub 2020 Jun 25.

Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.

Aims: Left ventricular (LV) thrombus is increasingly detected in patients with and without ischaemic heart disease due to the increased availability of cardiac magnetic resonance imaging. Risk factors include anterior ST elevation myocardial infarction, delayed reperfusion therapy, and non-ischaemic cardiomyopathy with severe LV systolic dysfunction. We aimed to report the characteristics and outcomes of patients with LV thrombus treated with either vitamin K antagonist (VKA) or direct oral anticoagulants (DOAC) with a view to describing differences in efficacy, specifically, subsequent thromboembolic events, thrombus resolution, and also side effects of therapy including clinically significant bleeding. Read More

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http://dx.doi.org/10.1002/ehf2.12718DOI Listing

Matrix Metalloproteinase-9 Relationship With Infarct Growth and Hemorrhagic Transformation in the Era of Thrombectomy.

Front Neurol 2020 9;11:473. Epub 2020 Jun 9.

Stroke Department, Pierre Wertheimer Hospital, Hospices Civils de Lyon, Bron, France.

To assess the relationship between matrix metalloproteinase 9 (MMP-9), a proteolytic enzyme involved in the breakdown of the blood-brain barrier, and infarct growth and hemorrhagic transformation in acute ischemic stroke (AIS) with large vessel occlusion (LVO) in the era of mechanical thrombectomy (MT) using the kinetics of MMP-9 and sequential magnetic resonance imaging (MRI). HIBISCUS-STROKE is a cohort study including AIS patients with LVO treated with MT following admission MRI. Patients underwent sequential assessment of MMP-9, follow-up CT at day 1, and MRI at day 6. Read More

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http://dx.doi.org/10.3389/fneur.2020.00473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296118PMC

Estimation of Stroke Volume and Aortic Valve Area in Patients with Aortic Stenosis: A Comparison of Echocardiography versus Cardiovascular Magnetic Resonance.

J Am Soc Echocardiogr 2020 Jun 21. Epub 2020 Jun 21.

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart & Lung Institute, Laval University, Québec City, Québec, Canada. Electronic address:

Background: In aortic stenosis, accurate measurement of left ventricular stroke volume (SV) is essential for the calculation of aortic valve area (AVA) and the assessment of flow status. Current American Society of Echocardiography and European Association of Cardiovascular Imaging guidelines suggest that measurements of left ventricular outflow tract diameter (LVOTd) at different levels (at the annulus vs 5 or 10 mm below) yield similar measures of SV and AVA. The aim of this study was to assess the effect of the location of LVOTd measurement on the accuracy of SV and AVA measured on transthoracic echocardiography (TTE) compared with cardiovascular magnetic resonance (CMR). Read More

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http://dx.doi.org/10.1016/j.echo.2020.03.020DOI Listing

Intracranial High-Grade Stenosis and Hyperhomocysteinemia Presenting as Cortical Subarachnoid Hemorrhage Concomitant with Acute Ischemic Stroke in a Young Man.

Am J Case Rep 2020 Jun 24;21:e920606. Epub 2020 Jun 24.

Department of Neurology, Henan Provincial People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, Henan, China (mainland).

BACKGROUND Cortical subarachnoid hemorrhage (cSAH) is a rare clinical presentation with different causes, but rarely happens along with acute ischemic stroke. Intracranial high-grade stenosis originated from brain has been regarded as an unusual cause of cSAH, especially in young adults. CASE REPORT A case of 33-year-old male presented with mild headache and spontaneous left-sided body weakness. Read More

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http://dx.doi.org/10.12659/AJCR.920606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327752PMC

Hypoperfusion Distal to Anterior Circulation Intracranial Atherosclerosis is Associated with Recurrent Stroke.

J Neuroimaging 2020 Jun 24. Epub 2020 Jun 24.

Department of Neurology, New York University, New York, NY.

Background And Purpose: In patients with symptomatic vertebrobasilar intracranial atherosclerotic disease (ICAD), impaired distal flow predicts recurrent stroke, but limited data exist on the association between perfusion status and recurrent stroke in anterior circulation ICAD.

Methods: This is a retrospective study of patients hospitalized for symptomatic ICAD with 50-99% stenosis of the intracranial carotid or middle cerebral artery. The primary outcome is recurrent symptomatic ischemic stroke in the territory of the artery with ≥50% stenosis within 90 days. Read More

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http://dx.doi.org/10.1111/jon.12710DOI Listing

Quantitative Analysis of the Cerebral Vasculature on Magnetic Resonance Angiography.

Sci Rep 2020 Jun 23;10(1):10227. Epub 2020 Jun 23.

Department of Neurology, Dell Medical School at The University of Texas, Austin, Texas, USA.

The arterial connections in the Circle of Willis are a central source of collateral blood flow and play an important role in pathologies such as stroke and mental illness. Analysis of the Circle of Willis and its variants can shed light on optimal methods of diagnosis, treatment planning, surgery, and quantification of outcomes. We developed an automated, standardized, objective, and high-throughput approach for categorizing and quantifying the Circle of Willis vascular anatomy using magnetic resonance angiography images. Read More

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http://dx.doi.org/10.1038/s41598-020-67225-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311427PMC

Cardiac MRI in common marmosets revealing age-dependency of cardiac function.

Sci Rep 2020 Jun 23;10(1):10221. Epub 2020 Jun 23.

Functional Imaging Laboratory, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany.

The aim of this study was to establish a feasible and robust magnetic resonance imaging protocol for the quantitative assessment of cardiac function in marmosets and to present normal values of cardiac function across different ages from young adult, middle-aged, to very old clinically healthy animals. Cardiac MRI of 33 anesthetized marmosets at the age of 2-15 years was performed at 9.4 T using IntraGate-FLASH that operates without any ECG-triggering and breath holding. Read More

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http://dx.doi.org/10.1038/s41598-020-67157-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311402PMC

Electroacupuncture promotes motor function and functional connectivity in rats with ischemic stroke: an animal resting-state functional magnetic resonance imaging study.

Acupunct Med 2020 Jun 23:964528420920297. Epub 2020 Jun 23.

College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Background: To evaluate whether electroacupuncture (EA) treatment at LI11 and ST36 could reduce motor impairments and enhance brain functional recovery in a rat model of ischemic stroke.

Methods: A rat model of middle cerebral artery occlusion (MCAO) was established. EA at LI11 and ST36 was started at 24 h (MCAO + EA group) after ischemic stroke modeling. Read More

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http://dx.doi.org/10.1177/0964528420920297DOI Listing

Effect of computed tomography perfusion post-processing algorithms on optimal threshold selection for final infarct volume prediction.

Neuroradiol J 2020 Jun 23:1971400920934122. Epub 2020 Jun 23.

Department of Biomedical Engineering, University at Buffalo, USA.

In acute ischemic stroke (AIS) patients, eligibility for endovascular intervention is commonly determined through computed tomography perfusion (CTP) analysis by quantifying ischemic tissue using perfusion parameter thresholds. However, thresholds are not uniform across all analysis methods due to dependencies on patient demographics and computational algorithms. This study aimed to investigate optimal perfusion thresholds for quantifying infarct and penumbra volumes using two post-processing CTP algorithms: Vitrea Bayesian and singular value decomposition plus (SVD+). Read More

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http://dx.doi.org/10.1177/1971400920934122DOI Listing

Quantitative Histogram Analysis on Intracranial Atherosclerotic Plaques: A High-Resolution Magnetic Resonance Imaging Study.

Stroke 2020 Jul 17;51(7):2161-2169. Epub 2020 Jun 17.

Department of Radiology (Z.S., J. Li, W.P., T.J., Q.L., J. Lu), Changhai Hospital, Naval Medical University, Shanghai, China.

Background And Purpose: Intracranial atherosclerosis is one of the main causes of stroke, and high-resolution magnetic resonance imaging provides useful imaging biomarkers related to the risk of ischemic events. This study aims to evaluate differences in histogram features between culprit and nonculprit intracranial atherosclerosis using high-resolution magnetic resonance imaging.

Methods: Two hundred forty-seven patients with intracranial atherosclerosis who underwent high-resolution magnetic resonance imaging sequentially between January 2015 and December 2016 were recruited. Read More

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http://dx.doi.org/10.1161/STROKEAHA.120.029062DOI Listing
July 2020
5.723 Impact Factor

Corticospinal Fibers With Different Origins Impact Motor Outcome and Brain After Subcortical Stroke.

Stroke 2020 Jul 17;51(7):2170-2178. Epub 2020 Jun 17.

Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, China (J.L., W.Q., H.D., C.Y.).

Background And Purpose: Motor deficit is the most common disability after stroke, and early prediction of motor outcome is critical for early interventions. Here, we constructed a fine map of the corticospinal tract (CST) for early prediction of motor outcome and for understanding the secondary brain changes after subcortical stroke.

Methods: Diffusion spectrum imaging data from 50 healthy adults were used to reconstruct fine maps of CST with different origins, including primary motor area (M1), primary sensory area (S1), premotor cortex, and supplementary motor area (SMA). Read More

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http://dx.doi.org/10.1161/STROKEAHA.120.029508DOI Listing

Matrix Metalloproteinase-9 and Monocyte Chemoattractant Protein-1 Are Associated With Collateral Status in Acute Ischemic Stroke With Large Vessel Occlusion.

Stroke 2020 Jul 17;51(7):2232-2235. Epub 2020 Jun 17.

Stroke Department (L.M., L.D., E.O., T.-H.C., N.N.), Hospices Civils de Lyon, France.

Background And Purpose: In ischemic stroke, inflammatory status may condition the development of collateral circulation. Here we assessed the relationship between systemic inflammatory biomarkers and collateral status in large vessel occlusion before mechanical thrombectomy.

Methods: HIBISCUS-STROKE is a cohort study including acute ischemic stroke patients with large vessel occlusion treated with mechanical thrombectomy following admission magnetic resonance imaging. Read More

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http://dx.doi.org/10.1161/STROKEAHA.120.029395DOI Listing

Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial.

Stroke 2020 Jul 17;51(7):1983-1990. Epub 2020 Jun 17.

Departments of Neurology (G.A., N.H.), Aarhus University Hospital, Denmark.

Background And Purpose: Delayed recanalization increases the risk of infarct growth and poor clinical outcome in acute ischemic stroke. The vasoactive agent theophylline has shown neuroprotective effects in animal stroke models but inconclusive results in case series and randomized clinical trials. The primary objective of this study was to evaluate whether theophylline, as an add-on to thrombolytic therapy, is safe and effective in acute ischemic stroke patients. Read More

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http://dx.doi.org/10.1161/STROKEAHA.119.027446DOI Listing

Thrombolysis Outcomes in Acute Ischemic Stroke by Fluid-Attenuated Inversion Recovery Hyperintense Arteries.

Stroke 2020 Jul 17;51(7):2240-2243. Epub 2020 Jun 17.

The George Institute for Global Health, Faculty of Medicine, University of New South Wales Sydney, Australia (Z.Z., S.Y., C.D., A.M., T.T.-Y., C.C., X.W., X.C., J.C., C.S.A.).

Background And Purpose: To determine factors associated with fluid-attenuated inversion recovery (FLAIR) hyperintense arteries (FLAIR-HAs) on magnetic resonance imaging and their prognostic significance in thrombolysis-treated patients with acute ischemic stroke from the ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) trial alteplase-dose arm.

Methods: Patients with acute ischemic stroke (N=293) with brain magnetic resonance imaging (FLAIR and diffusion-weighted imaging sequences) scanned <4.5 hours of symptom onset were assessed for location and extent (score) of FLAIR-HAs, infarct volume, large vessel occlusion (LVO), and other ischemic signs. Read More

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http://dx.doi.org/10.1161/STROKEAHA.119.028550DOI Listing

Association Between Immunosuppressive Treatment and Outcomes of Cerebral Amyloid Angiopathy-Related Inflammation.

JAMA Neurol 2020 Jun 22. Epub 2020 Jun 22.

J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston.

Importance: Cerebral amyloid angiopathy-related inflammation (CAA-ri), a distinct subtype of cerebral amyloid angiopathy, is characterized by an autoimmune reaction to cerebrovascular β-amyloid deposits. Outcomes and response to immunosuppressive therapy for CAA-ri are poorly understood.

Objective: To identify clinical, neuroimaging, laboratory, pathologic, or treatment-related associations with outcomes after an episode of CAA-ri. Read More

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http://dx.doi.org/10.1001/jamaneurol.2020.1782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309570PMC

Catheter ablation of atrial fibrillation after pericardiectomy: multi-center experience in China.

Ann Transl Med 2020 May;8(9):580

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Background: To study the effectiveness and safety of atrial fibrillation (AF) catheter ablation after pericardiectomy.

Methods: Data of 24 consecutive AF patients after pericardiectomy underwent catheter ablation from five centers were collected and analyzed retrospectively. All patients were followed up at 1, 3, and 12 months after catheter ablation. Read More

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http://dx.doi.org/10.21037/atm.2020.04.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290548PMC

Consensus Guidelines of the French Society of Neuroradiology (SFNR) on the use of Gadolinium-Based Contrast agents (GBCAs) and related MRI protocols in Neuroradiology.

J Neuroradiol 2020 06 18. Epub 2020 Jun 18.

MRI center, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France; Université Lyon 1, CREATIS-LRMN, CNRS/UMR/5220-INSERM U630, Villeurbanne, France.

Gadolinium-based contrast agents (GBCAs) are used in up to 35% of magnetic resonance imaging (MRI) examinations and are associated with an excellent safety profile. Nevertheless, two main issues have arisen in the last two decades: the risk of nephrogenic systemic fibrosis and the risk of gadolinium deposition and retention. As a first step, this article reviews the different categories of GBCAs available in neuroradiology, their issues, and provides updates regarding the use of these agents in routine daily practice. Read More

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http://dx.doi.org/10.1016/j.neurad.2020.05.008DOI Listing

L-3-n-butylphthalide attenuates inflammation response and brain edema in rat intracerebral hemorrhage model.

Aging (Albany NY) 2020 Jun 21;12. Epub 2020 Jun 21.

Department of Neurology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.

L-3-n-butylphthalide(NBP), a compound found in Linn seed extracts, has a therapeutic effect on acute ischemic stroke. The pathological inflammatory pathways and consequent brain edema in intracerebral hemorrhage (ICH) share some similar characteristics with ischemic stroke. We hypothesized that NBP has anti-inflammatory and therapeutic effects on rats with ICH. Read More

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http://dx.doi.org/10.18632/aging.103342DOI Listing

Left Atrial Late Gadolinium Enhancement is Associated With Incident Atrial Fibrillation as Detected by Continuous Monitoring With Implantable Loop Recorders.

JACC Cardiovasc Imaging 2020 Jun 16. Epub 2020 Jun 16.

Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Objectives: We hypothesized that left atrial (LA) fibrosis was associated with incident atrial fibrillation (AF) as detected by continuous long-term monitoring in an at-risk population.

Background: LA late gadolinium enhancement (LGE) measured with cardiac magnetic resonance is emerging as a marker of atrial fibrosis and has been associated with worse outcomes in AF ablation procedures; however, the prognostic value of LA LGE for incident AF remains unknown.

Methods: Cardiac magnetic resonance, including measurement of left ventricular and LA volumes and function, as well as left ventricular extracellular volume fraction and LA LGE, was acquired in 68 patients aged at least 70 years with risk factors for stroke. Read More

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http://dx.doi.org/10.1016/j.jcmg.2020.03.024DOI Listing