30,262 results match your criteria Magnetic Resonance Imaging in Acute Stroke


Cerebrovascular disease burden in late-onset non-lesional focal epilepsy.

Seizure 2019 Feb 8;66:31-35. Epub 2019 Feb 8.

Epilepsy Unit, Neurology Department, Vall d'Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain. Electronic address:

Purpose: Late-onset non-lesional focal epilepsy, defined as new-onset seizures in patients older than 60 years, is diagnosed increasingly more often in relation to aging of the population. It has been attributed mainly to occult cerebral small vessel disease (SVD), although high levels of evidence to support this notion are lacking. This study aimed to evaluate the burden of leukoaraiosis, a marker of cerebral SVD, and hippocampal atrophy in patients with late-onset epilepsy (LOE). Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.004DOI Listing
February 2019

White Matter Hyperintensities in Alzheimer's Disease: A Lesion Probability Mapping Study.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Medical University of Graz, Graz, Austria.

Background/objective: Higher white matter hyperintensity (WMH) load has been reported in Alzheimer's disease (AD) patients in different brain regions when compared to controls. We aimed to assess possible differences of WMH spatial distribution between AD patients and age-matched controls by means of lesion probability maps.

Methods: The present study included MRI scans of 130 probable AD patients with a mean age of 73. Read More

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http://dx.doi.org/10.3233/JAD-180982DOI Listing
February 2019

The Clinical Phenotype of Vascular Cognitive Impairment in Patients with Type 2 Diabetes Mellitus.

J Alzheimers Dis 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurology, Brain Center Rudolph Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Type 2 diabetes mellitus (T2DM) increases the risk of vascular cognitive impairment (VCI). It is unknown which type of vascular lesions and co-morbid etiologies, in particular Alzheimer's disease pathology, are associated with T2DM in patients with VCI, and how this relates to cognition and prognosis.

Objective: To compare brain MRI and cerebrospinal fluid (CSF) markers, cognition, and prognosis in patients with possible VCI with and without T2DM. Read More

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http://dx.doi.org/10.3233/JAD-180914DOI Listing
February 2019

Reproducibility of semi-automated three-dimensional volumetric analysis using cardiac computed tomography in patients with left ventricular assist device.

Cardiovasc Revasc Med 2019 Jan 23. Epub 2019 Jan 23.

MedStar Washington Hospital Center, Washington, D.C., United States of America; MedStar Cardiovascular Research Network, Washington, D.C., United States of America. Electronic address:

Background: Multi-detector gated cardiac computed tomography (CCT) allows three-dimensional (3D) quantification of cardiac chambers and is clinically indicated to assess left ventricular assist device (LVAD) malfunction and complications. Automated volumetric analysis is, however, disrupted by inflow cannula artifact in patients with LVAD. With this study, we evaluated intra-observer variability in semi-automated 3D cardiac volumetric analysis using CCT in patients with LVADs. Read More

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http://dx.doi.org/10.1016/j.carrev.2019.01.024DOI Listing
January 2019

Deep Venous Thrombosis with Decreased Cerebral Blood Flow to the Thalamus was Completely Restored by Factor Xa Inhibitor.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, Kanazawa Medical Center, Kanazawa, Japan.

Background: Cerebral venous thrombosis is rare and an uncommon cause of stroke and has diverse etiologies and varied clinical presentations. Here, we report 2 cases of deep cerebral venous thrombosis.

Case Description: A 64-year-old woman presented with cerebral venous thrombosis due to a hypercoagulable state associated with ovarian tumor. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.023DOI Listing
February 2019

Evaluation of the sensitivity of Rρ MRI to pH and macromolecular density.

Magn Reson Imaging 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology, Box 218, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom, CB2 0QQ. Electronic address:

The tumor microenvironment is characteristically acidic and this extracellular acidosis is known to play a role in carcinogenesis and metastasis and can affect tumor chemosensitivity and radiosensitivity. Intracellular pH has been used as a possible biomarker of salvageable tissue in ischemic stroke. A non-invasive MRI-based approach for the determination and imaging of cerebral pH would be a powerful tool in cancer diagnosis and monitoring, as well as stroke treatment planning. Read More

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http://dx.doi.org/10.1016/j.mri.2019.02.004DOI Listing
February 2019

Twenty-and-a-half syndrome: a case report.

J Med Case Rep 2019 Feb 15;13(1):35. Epub 2019 Feb 15.

Department of Neurology, Sri Aurobindo Medical College & P.G. Institute, 4th Floor, Sanwer Road, Indore, MP, 453555, India.

Background: In the list of named numerical neuro-ophthalmological syndromes, such as one-and-a-half syndrome and others, we report for the first time twenty-and-a-half syndrome, which is characterized by one-and-a-half syndrome with bilateral seventh and right fifth nerve palsy (1.5 + 7 + 7 + 5 = 20.5) in a patient with ischemic stroke. Read More

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http://dx.doi.org/10.1186/s13256-019-1980-4DOI Listing
February 2019

One-Year Risk of Recurrent Stroke and Death Associated with Vertebrobasilar Artery Stenosis and Occlusion in a Cohort of 10,515 Patients.

Cerebrovasc Dis 2019 Feb 14;47(1-2):40-47. Epub 2019 Feb 14.

College of Medicine, China Medical University, Taichung, Taiwan.

Background: The natural history of vertebrobasilar artery (VBA) stenosis or occlusion remains understudied.

Methods: Patients with diagnosis of ischemic stroke or transient ischemic attack (TIA) who were noted to have VBA stenosis based on computed tomography or magnetic resonance imaging or catheter-based angiogram were selected from Taiwan Stroke Registry. Cox proportional hazards model was used to determine the hazards ratio (HR) of recurrent stroke and death within 1 year of index event in various groups based on severity of VBA stenosis (none to mild: 0-49%; moderate to severe: 50-99%: occlusion: 100%) after adjusting for differences in demographic and clinical characteristics between groups at baseline evaluation. Read More

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http://dx.doi.org/10.1159/000495418DOI Listing
February 2019

Associations of High Intensities on Magnetization-Prepared Rapid Acquisition with Gradient Echo with Aortic Complicated Lesions in Ischemic Stroke Patients.

Cerebrovasc Dis 2019 Feb 14;47(1-2):15-23. Epub 2019 Feb 14.

Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.

Background: Aortic complicated lesions (ACLs) are key parameters for evaluating aortic embolic sources in embolic stroke, and are usually diagnosed using transesophageal echocardiography (TEE). However, alternative methods for diagnosing ACLs have not been well established. We investigated associations between high-intensity areas on T1-weighted imaging (T1WI) with magnetization-prepared rapid acquisition with gradient echo (MPRAGE) and ACLs on TEE among ischemic stroke patients. Read More

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http://dx.doi.org/10.1159/000497068DOI Listing
February 2019

Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis.

Int J Stroke 2019 Feb 14:1747493019830321. Epub 2019 Feb 14.

1 Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.

Background: Perivascular spaces, visible on brain magnetic resonance imaging, are thought to be associated with small vessel disease, neuroinflammation, and to be important for cerebral hemodynamics and interstitial fluid drainage.

Aims: To benchmark current knowledge on perivascular spaces associations with risk factors, neurological disorders, and neuroimaging lesions, using systematic review and meta-analysis.

Summary Of Review: We searched three databases for perivascular spaces publications, calculated odds ratios with 95% confidence interval and performed meta-analyses to assess adjusted associations with perivascular spaces. Read More

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http://dx.doi.org/10.1177/1747493019830321DOI Listing
February 2019

FLAIR vascular hyperintensity in acute stroke is associated with collateralization and functional outcome.

Eur Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No.68, Changle Road, Nanjing, 210006, China.

Purpose: Fluid-attenuated inversion recovery vascular hyperintensity (FVH) is frequently found in stroke patients after intracranial arterial occlusion, but the prognostic value of FVH findings is unclear. We assessed whether FVH is associated with cerebral collateral status and functional outcome in patients with acute stroke patients receiving endovascular therapy.

Methods: FVH score, American Society of Interventional and Therapeutic Neuroradiology (ASITN) grade, the functional outcome at 3 months (modified Rankin Scale (mRS)), and other clinical data were collected for 37 acute stroke patients with large vessel occlusion (LVO) receiving MRI before and after endovascular therapy. Read More

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http://dx.doi.org/10.1007/s00330-019-06022-0DOI Listing
February 2019

Aphasia rehabilitation based on mirror neuron theory: a randomized-block-design study of neuropsychology and functional magnetic resonance imaging.

Neural Regen Res 2019 Jun;14(6):1004-1012

Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

When watching someone performs an action, mirror neurons are activated in a way that is very similar to the activation that occurs when actually performing that action. Previous single-sample case studies indicate that hand-action observation training may lead to activation and remodeling of mirror neuron systems, which include important language centers, and may improve language function in aphasia patients. In this randomized-block-design experiment, we recruited 24 aphasia patients from, Zhongda Hospital, Southeast University, China. Read More

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http://dx.doi.org/10.4103/1673-5374.250580DOI Listing

Cerebral microbleeds are associated with cognitive decline early after ischemic stroke.

J Neurol 2019 Feb 14. Epub 2019 Feb 14.

Department of Neurology, University Hospital of Würzburg, Josef-Schneider Strasse 11, 97080, Würzburg, Germany.

Background And Purpose: The present study aimed to investigate whether cerebral microbleeds (CMB) are associated with vascular cognitive decline (VCD) already in the early course after ischemic stroke, and-if so-whether distinct cognitive domains are affected more preferentially by CMB.

Methods: In a prospective cohort study, cognitive performance was examined in 33 stroke patients showing ≥ 1 CMB on MRI. Matched for age, gender, clinical and radiological characteristics, 33 stroke survivors without CMB served as a control group. Read More

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http://dx.doi.org/10.1007/s00415-019-09236-wDOI Listing
February 2019

Diffuse optical tomography for the detection of perinatal stroke at the cot side: a pilot study.

Pediatr Res 2019 Feb 13. Epub 2019 Feb 13.

neoLAB, The Evelyn Perinatal Imaging Centre, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.

Background: Perinatal stroke is a potentially debilitating injury, often under-diagnosed in the neonatal period. We conducted a pilot study investigating the role of the portable, non-invasive brain monitoring technique, diffuse optical tomography (DOT), as an early detection tool for infants with perinatal stroke.

Methods: Four stroke-affected infants were scanned with a DOT system within the first 3 days of life and compared to four healthy control subjects. Read More

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http://dx.doi.org/10.1038/s41390-018-0263-xDOI Listing
February 2019

Cerebral Vasculitis Complicating Pneumococcal Meningitis.

Eur J Case Rep Intern Med 2018 25;5(5):000819. Epub 2018 May 25.

Medical Intensive Care Unit, Farhat Hached Hospital, Sousse, Tunisia.

Introduction: Cerebral vasculitis is an uncommon life-threatening complication of community-acquired bacterial meningitis.

Patient And Methods: We report the case of a 64-year-old woman with pneumococcal meningitis who developed parainfectious vasculitis causing ischaemic brain damage. Cerebral magnetic resonance imaging (MRI) confirmed the diagnosis. Read More

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http://dx.doi.org/10.12890/2018_000819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346924PMC
May 2018
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Signal variance-based collateral index in DSC perfusion: A novel method to assess leptomeningeal collateralization in acute ischaemic stroke.

J Cereb Blood Flow Metab 2019 Feb 13:271678X19831024. Epub 2019 Feb 13.

2 Institute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany.

As a determinant of the progression rate of the ischaemic process in acute large-vessel stroke, the degree of collateralization is a strong predictor of the clinical outcome after reperfusion therapy and may influence clinical decision-making. Therefore, the assessment of leptomeningeal collateralization is of major importance. The purpose of this study was to develop and evaluate a quantitative and observer-independent method for assessing leptomeningeal collateralization in acute large-vessel stroke based on signal variance characteristics in T2*-weighted dynamic susceptibility contrast (DSC) perfusion-weighted MR imaging (PWI). Read More

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http://dx.doi.org/10.1177/0271678X19831024DOI Listing
February 2019

Punctate white-matter lesions in the full-term newborn: Underlying aetiology and outcome.

Eur J Paediatr Neurol 2019 Jan 26. Epub 2019 Jan 26.

Department of Neonatology, Wilhelmina Children's Hospital, Utrecht, University Medical Center Utrecht, Utrecht University, the Netherlands.

Background: Punctate white matter lesions (PWMLs) are small focal patches of increased signal intensity (SI) on T1- and decreased SI on T2-weighted magnetic resonance imaging (MRI). To date, there have been few reports of PWMLs in term born infants.

Objective: To identify associated diagnoses and factors predictive of clinical outcome in (near) term infants with PWMLs. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.005DOI Listing
January 2019
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Cortical Cerebral Microinfarcts on 3T Magnetic Resonance Imaging in Patients With Carotid Artery Stenosis.

Stroke 2019 Feb 12:STROKEAHA118023781. Epub 2019 Feb 12.

From the Department of Neurology, Osaka University Graduate School of Medicine, Japan (J.T., K.M., S.O., K.T., T.S., M.S., H.M.).

Background and Purpose- Carotid artery stenosis is common in the elderly and contributes to cognitive impairment and dementia. Cortical cerebral microinfarcts (CMIs) play an important role in vascular cognitive impairment and dementia. We aimed to investigate the association between CMIs on 3T magnetic resonance imaging and clinical and radiological features, including plaque morphology, and cognitive function in patients with carotid stenosis. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023781DOI Listing
February 2019
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Magnetic Resonance Imaging or Computed Tomography Before Treatment in Acute Ischemic Stroke.

Stroke 2019 Feb 12:STROKEAHA118023882. Epub 2019 Feb 12.

From the Imaging Department, INSERM UMR S1266, Sainte-Anne Hospital, Paris Descartes University, France (C.P., L.L., W.B.H., J.B., M.E., G.B., O.N., C.O.).

Background and Purpose- The acute management of stroke patients requires a fast and efficient screening imaging modality. We compared workflow and functional outcome in acute ischemic stroke patients screened by magnetic resonance imaging (MRI) or computed tomography (CT) before treatment in the THRACE trial (Thrombectomie des Artères Cérébrales), with the emphasis on the duration of the imaging step. Methods- The THRACE randomized trial (June 2010 to February 2015) evaluated the efficacy of mechanical thrombectomy after intravenous tPA (tissue-type plasminogen activator) in ischemic stroke patients with proximal occlusion. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023882DOI Listing
February 2019

Characterization of Functional Brain Connectivity towards Optimization of Music Selection for Therapy - A fMRI study.

Int J Neurosci 2019 Feb 11:1-9. Epub 2019 Feb 11.

b MRI core, Houston Methodist Research Institute , Houston TX , USA.

Background: Music therapy, a non-traditional approach to patient care, has long been used to achieve a wide variety of positive results. A better understanding of the connection and therapeutic potential of music, music therapy, and music medicine (music administered without an interactive therapeutic relationship) to individuals by exploring music's effect on the brain remains a topic of active research.

Objective: This study is aimed at investigating the effect of different music genres and individualized music selection on brain functional connectivity (FC) measured by functional magnetic resonance imaging (fMRI). Read More

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http://dx.doi.org/10.1080/00207454.2019.1581189DOI Listing
February 2019

Investigation of the emotional network in depression after stroke: A study of multivariate Granger causality analysis of fMRI data.

J Affect Disord 2019 Feb 6;249:35-44. Epub 2019 Feb 6.

Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. Electronic address:

Objective: Depression after stroke (DAS) is a serious complication of stroke that significantly restricts rehabilitation. Brain imaging technology is an important method for studying the emotional network of DAS. However, few studies have focused on dynamic interactions within the network. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.020DOI Listing
February 2019

Development and Validation of a Prognostic Model of Swallowing Recovery and Enteral Tube Feeding After Ischemic Stroke.

JAMA Neurol 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Kantonsspital St Gallen, St Gallen, Switzerland.

Importance: Predicting the duration of poststroke dysphagia is important to guide therapeutic decisions. Guidelines recommend nasogastric tube (NGT) feeding if swallowing impairment persists for 7 days or longer and percutaneous endoscopic gastrostomy (PEG) placement if dysphagia does not recover within 30 days, but, to our knowledge, a systematic prediction method does not exist.

Objective: To develop and validate a prognostic model predicting swallowing recovery and the need for enteral tube feeding. Read More

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http://dx.doi.org/10.1001/jamaneurol.2018.4858DOI Listing
February 2019
1 Read

Late-onset mitochondrial disease in a patient with MELAS and mitochondrial DNA T14487C mutation.

Chin Med J (Engl) 2019 Feb 5. Epub 2019 Feb 5.

Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong 250000, China.

We report a case of a 58-year-old male who presented with stroke-like episodes and late-onset mitochondrial encephalopathy. Brain magnetic resonance imaging (MRI) revealed multiple lesions in different locations, including in the left hypothalamus, bilateral parietal lobe, left occipital lobe, centrum semiovale and right cerebellar hemisphere. Muscle histopathological analysis showed no myopathic changes. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000139DOI Listing
February 2019
1.016 Impact Factor

Effect of disease-modifying therapies on subcortical gray matter atrophy in multiple sclerosis.

Mult Scler 2019 Feb 11:1352458519826364. Epub 2019 Feb 11.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background:: The effects of disease-modifying therapies (DMTs) on region-specific brain atrophy in multiple sclerosis (MS) are unclear.

Objective:: To determine the effects of higher versus lower efficacy DMTs on rates of brain substructure atrophy in MS.

Methods:: A non-randomized, observational cohort of people with MS followed with annual brain magnetic resonance imaging (MRI) was evaluated retrospectively. Read More

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http://dx.doi.org/10.1177/1352458519826364DOI Listing
February 2019
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fMRI prediction of naming change after adult temporal lobe epilepsy surgery: Activation matters.

Epilepsia 2019 Feb 11. Epub 2019 Feb 11.

Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Objective: We aimed to predict language deficits after epilepsy surgery. In addition to evaluating surgical factors examined previously, we determined the impact of the extent of functional magnetic resonance imaging (fMRI) activation that was resected on naming ability.

Method: Thirty-five adults (mean age 37. Read More

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http://dx.doi.org/10.1111/epi.14656DOI Listing
February 2019

Artery of Percheron infarction: a rare cause of somnolence in a patient with sepsis and atrial fibrillation.

Oxf Med Case Reports 2018 Jul 5;2018(7):omy032. Epub 2018 Jul 5.

Department of Neurology, Advocate Illinois Masonic Medical Center, Chicago, IL, USA.

Artery of Percheron (AOP) occlusion is a rare cause of ischemic stroke characterized by bilateral para-median thalamic infarcts. It usually presents with altered mental status, hyper-somnolence and ocular movement disorders. Here, we report a case of cardio-embolic AOP infarction in a 72-year-old man with sepsis and new-onset atrial fibrillation. Read More

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http://dx.doi.org/10.1093/omcr/omy032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363084PMC
July 2018
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MELAS syndrome with m.4450 G > A mutation in mitochondrial tRNA gene.

Brain Dev 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, Jichi Medical University, Japan. Electronic address:

Mutations in the mitochondrial tRNA gene have been reported in only five patients to date, all of whom presented with muscle weakness and exercise intolerance as signs of myopathy. We herein report the case of a 12-year-old girl with focal epilepsy since the age of eight years. At age 11, the patient developed sudden visual disturbances and headaches accompanied by recurrent, stroke-like episodes with lactic acidosis (pH 7. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183059
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http://dx.doi.org/10.1016/j.braindev.2019.01.006DOI Listing
February 2019
2 Reads

Misdiagnosis of multiple sclerosis in a female heterozygote with Fabry's disease.

Authors:
Joseph R Berger

Mult Scler Relat Disord 2019 Jan 30;30:45-47. Epub 2019 Jan 30.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, PCAM-South Tower #765, 3400 Convention Avenue, Philadelphia, PA 19104, USA. Electronic address:

Fabry's disease is an X-linked disorder of enzyme alpha-galactosidase A which leads to an accumulation of the glycolipids in lysosomes in vessels and organs. The disorder is rare with an estimated incidence of 1 in 40,000 and disease occurs more rarely in women than men. Paresthesias, hearing loss, and stroke are the typical neurological manifestations. Read More

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http://dx.doi.org/10.1016/j.msard.2019.01.040DOI Listing
January 2019
1 Read

Season and myocardial injury in patients with ST-segment elevation myocardial infarction: A cardiac magnetic resonance imaging study.

PLoS One 2019 8;14(2):e0211807. Epub 2019 Feb 8.

Department of Radiology, Cardiovascular Imaging Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Little is known about the causality and pathological mechanism underlying the association of seasonal variation with myocardial injury in patients with ST-segment elevation myocardial infarction (STEMI).

Objective: We evaluated the association of seasonal effect with myocardial injury using cardiovascular magnetic resonance (CMR) imaging in STEMI patients undergoing primary percutaneous coronary intervention (PCI).

Methods: In 279 patients undergoing primary PCI for STEMI, CMR was performed for a median of 3. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211807PLOS
February 2019

Persistent Target Mismatch Profile >24 Hours After Stroke Onset in DEFUSE 3.

Stroke 2019 Feb 8:STROKEAHA118023392. Epub 2019 Feb 8.

From the Stanford Stroke Center, Stanford University School of Medicine, CA (S.C., M.M., S.K., A.Y., M.G.L., G.W.A.).

Background and Purpose- Efficacy of endovascular thrombectomy has been demonstrated up to 24 hours after stroke onset in patients selected with perfusion imaging. We hypothesized that a persistent favorable perfusion profile exists in some patients beyond 24 hours from the onset and can be predicted by a lower baseline hypoperfusion intensity ratio, which indicates favorable collaterals. Methods- We identified control arm patients from the DEFUSE 3 trial (The Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke) with a diffusion weighted imaging and perfusion magnetic resonance imaging performed 24 hours following randomization and compared imaging and clinical variables between patients with persistent mismatch versus patients who no longer had a mismatch 24 hours after randomization. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023392DOI Listing
February 2019
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High risk of silent stroke in older bipolar patients with typical-onset age.

Psychogeriatrics 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Aim: Older patients with bipolar disorder (BD) are at a high risk of stroke. Silent stroke could be neglected in BD patients after middle age, particularly in those with illness onset at the young age. Therefore, we investigated the morbidity and related factors for stroke in older BD patients with typical-onset age. Read More

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http://dx.doi.org/10.1111/psyg.12419DOI Listing
February 2019
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Exercise cardiovascular magnetic resonance imaging allows differentiation of low-risk pulmonary arterial hypertension.

J Heart Lung Transplant 2019 Jan 25. Epub 2019 Jan 25.

Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address:

Background: Patients with pulmonary arterial hypertension (PAH) have a decreased ability to compensate for demands on increased cardiac output, such as during exercise. In this study we aimed to differentiate cardiac exercise responses in patients with PAH, stratified according to known measurements of disease severity.

Methods: Right and left ventricular end-diastolic volume and end-systolic volume, stroke volume (SV), and cardiac output were measured in 20 patients with PAH and a lower risk of mortality with 6-month intervals using cardiovascular magnetic resonance (CMR) imaging during rest and during ergometer exercise (totaling 44 scans). Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1305DOI Listing
January 2019
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Asymptomatic moderate carotid artery stenosis with intraplaque hemorrhage: Progression of degree of stenosis and new ischemic stroke.

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan.

Carotid intraplaque hemorrhage (IPH) plays a critical role in the progression of carotid atherosclerotic disease. IPH was associated with high intensity signal (HIS) in the plaque on Maximum intensity projection (MIP) images from routine three dimensional magnetic resonance imaging (3D-TOF MRA). The aim of this study was to evaluate the relationships among HIS, new ipsilateral ischemic stroke and a progression rate in carotid plaques with moderate stenosis. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.033DOI Listing
February 2019
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Does Clot Burden Score on Baseline T2*-MRI Impact Clinical Outcome in Acute Ischemic Stroke Treated with Mechanical Thrombectomy?

J Stroke 2019 Jan 31;21(1):91-100. Epub 2019 Jan 31.

Paris Descartes University, INSERM UMR 894 and Department of Neuroradiology, Sainte-Anne Hospital Center, Paris, France.

Background And Purpose: A long clot, defined by a low (0-6) clot burden score (CBS) assessed by T2*-MR sequence, is associated with worse clinical outcome after intravenous thrombolysis (IVT) for acute ischemic stroke than is a small clot (CBS, 7-10). The added benefit of mechanical thrombectomy (MT) might be higher in patients with long clot. The aim of this pre-specified post hoc analysis of the THRombectomie des Artères CErebrales (THRACE) trial was to assess the association between T2*-CBS, successful recanalization and clinical outcome. Read More

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http://dx.doi.org/10.5853/jos.2018.01921DOI Listing
January 2019
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Estimation of Acute Infarct Volume with Reference Maps: A Simple Visual Tool for Decision Making in Thrombectomy Cases.

J Stroke 2019 Jan 31;21(1):69-77. Epub 2019 Jan 31.

Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background And Purpose: Thrombectomy within 24 hours can improve outcomes in selected patients with a clinical-infarct mismatch. We devised an easy-to-use visual estimation tool that allows infarct volume estimation in centers with limited resources.

Methods: We identified 1,031 patients with cardioembolic or large-artery atherosclerosis infarction on diffusion-weighted images (DWIs) obtained before recanalization therapy and within 24 hours of onset, and occlusion of the internal carotid or middle cerebral artery. Read More

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http://dx.doi.org/10.5853/jos.2018.03202DOI Listing
January 2019

Post-Thrombolysis Recanalization in Stroke Referrals for Thrombectomy: Incidence, Predictors, and Prediction Scores.

Stroke 2018 12;49(12):2975–2982

From the Neurology Department (P.S., G.T., J.-L.M., J.-C.B.), INSERM U894, Sainte-Anne Hospital, Université Paris Descartes, Paris, France.

Background and Purpose—Whether all acute stroke patients with large vessel occlusion need to undergo intravenous thrombolysis before mechanical thrombectomy (MT) is debated as (1) the incidence of post-thrombolysis early recanalization (ER) is still unclear; (2) thrombolysis may be harmful in patients unlikely to recanalize; and, conversely, (3) transfer for MT may be unnecessary in patients highly likely to recanalize. Here, we determined the incidence and predictors of post-thrombolysis ER in patients referred for MT and derive ER prediction scores for trial design. Methods—Registries from 4 MT-capable centers gathering patients referred for MT and thrombolyzed either on site (mothership) or in a non MT-capable center (drip-and-ship) after magnetic resonance– or computed tomography–based imaging between 2015 and 2017. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.022335DOI Listing
December 2018

The spectrum of spinal cord lesions in a primate model of multiple sclerosis.

Mult Scler 2019 Feb 7:1352458518822408. Epub 2019 Feb 7.

Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Background:: Experimental autoimmune encephalomyelitis (EAE) in the common marmoset is a nonhuman primate model of multiple sclerosis (MS) that shares numerous clinical, radiological, and pathological features with MS. Among the clinical features are motor and sensory deficits that are highly suggestive of spinal cord (SC) damage.

Objective:: To characterize the extent and nature of SC damage in symptomatic marmosets with EAE using a combined magnetic resonance imaging (MRI) and histopathology approach. Read More

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http://dx.doi.org/10.1177/1352458518822408DOI Listing
February 2019

Special issue on fluorine-19 magnetic resonance: technical solutions, research promises and frontier applications.

MAGMA 2019 Feb 7. Epub 2019 Feb 7.

Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.

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http://dx.doi.org/10.1007/s10334-019-00741-7DOI Listing
February 2019

Stabilization of vulnerable carotid plaques with proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab.

Acta Neurochir (Wien) 2019 Feb 7. Epub 2019 Feb 7.

Department of Neurosurgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga-shi, Saga, 849-8501, Japan.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, a novel class of monoclonal antibodies, reduce low-density lipoprotein cholesterol levels and improve outcomes of myocardial infarction and stroke. However, the effects of PCSK9 inhibitors on carotid plaques remain unclear. We describe three patients treated with PCSK9 inhibitor alirocumab for progressive carotid stenosis despite lipid-lowering statin therapy. Read More

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http://dx.doi.org/10.1007/s00701-019-03825-4DOI Listing
February 2019
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Evaluating the effect and mechanism of upper limb motor function recovery induced by immersive virtual-reality-based rehabilitation for subacute stroke subjects: study protocol for a randomized controlled trial.

Trials 2019 Feb 6;20(1):104. Epub 2019 Feb 6.

China-USA Neuroimaging Research Institute, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.

Background: There is compelling evidence of beneficial effects of non-immersive virtual reality (VR)-based intervention in the rehabilitation of patients with stroke, whereby patients experience both the real world and the virtual environment. However, to date, research on immersive VR-based rehabilitation is minimal. This study aims to design a randomized controlled trial to assess the effectiveness of immersive VR-based upper extremity rehabilitation in patients with subacute stroke and explore the underlying brain mechanisms of immersive VR-based rehabilitation. Read More

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http://dx.doi.org/10.1186/s13063-019-3177-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366030PMC
February 2019
1 Read
2.117 Impact Factor

Ischemic Core and Hypoperfusion Volumes Correlate With Infarct Size 24 Hours After Randomization in DEFUSE 3.

Stroke 2019 Feb 6:STROKEAHA118023177. Epub 2019 Feb 6.

From the Department of Neurology and Neurological Sciences, Stanford University School of Medicine, CA (V.R., S.C., A.Y., M.M., M.G.L., G.W.A.).

Background and Purpose- Accurate prediction of the subsequent infarct volume early after stroke onset helps determine appropriate interventions and prognosis. In the DEFUSE 3 trial (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke), we evaluated the accuracy of baseline ischemic core and hypoperfusion volumes for predicting infarct volume 24 hours after randomization to endovascular thrombectomy versus medical management. We also assessed if the union of baseline ischemic core and the volume of persistent hypoperfusion at 24 hours after randomization predicts infarct volume. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023177DOI Listing
February 2019

High-resolution vessel wall magnetic resonance imaging of carotid and intracranial vessels.

Acta Radiol 2019 Feb 6:284185119826538. Epub 2019 Feb 6.

1 Radiology Department, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.

Carotid and intracranial imaging play an essential role in the comprehensive evaluation and prevention for stroke patients. High-resolution vessel wall magnetic resonance imaging (HR VW-MRI) has been applied in carotid and intracranial arteries with optimal ability in displaying the features of various vascular diseases. Recent advanced MRI techniques can not only help in the differential diagnosis of vascular diseases but can also provide information on pathogenesis exploration of underlying mechanisms, follow-up monitoring, and determination of prognosis for patients with cerebral strokes. Read More

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http://dx.doi.org/10.1177/0284185119826538DOI Listing
February 2019

Visualizing the Distribution of Matrix Metalloproteinases in Ischemic Brain Using In Vivo F-Magnetic Resonance Spectroscopic Imaging.

Contrast Media Mol Imaging 2019 6;2019:8908943. Epub 2019 Jan 6.

Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan.

Matrix metalloproteinases (MMPs) damage the neurovascular unit, promote the blood-brain barrier (BBB) disruption following ischemic stroke, and play essential roles in hemorrhagic transformation (HT), which is one of the most severe side effects of thrombolytic therapy. However, no biomarkers have presently been identified that can be used to track changes in the distribution of MMPs in the brain. Here, we developed a new F-molecular ligand, TGF-019, for visualizing the distribution of MMPs in vivo using F-magnetic resonance spectroscopic imaging (F-MRSI). Read More

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http://dx.doi.org/10.1155/2019/8908943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339703PMC
January 2019
1 Read

EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke.

Acta Neuropathol Commun 2019 Feb 5;7(1):15. Epub 2019 Feb 5.

Department of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany.

Local cerebral hypoperfusion causes ischemic stroke while driving multiple cell-specific responses including inflammation, glutamate-induced neurotoxicity mediated via NMDAR, edema formation and angiogenesis. Despite the relevance of these pathophysiological mechanisms for disease progression and outcome, molecular determinants controlling the onset of these processes are only partially understood. In this context, our study intended to investigate the functional role of EphB2, a receptor tyrosine kinase that is crucial for synapse function and binds to membrane-associated ephrin-B ligands. Read More

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http://dx.doi.org/10.1186/s40478-019-0669-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362601PMC
February 2019
3 Reads

Brain-Machine Interface in Chronic Stroke: Randomized Trial Long-Term Follow-up.

Neurorehabil Neural Repair 2019 Feb 5:1545968319827573. Epub 2019 Feb 5.

1 University of Tubingen, Tübingen, Germany.

Background: Brain-machine interfaces (BMIs) have been recently proposed as a new tool to induce functional recovery in stroke patients.

Objective: Here we evaluated long-term effects of BMI training and physiotherapy in motor function of severely paralyzed chronic stroke patients 6 months after intervention.

Methods: A total of 30 chronic stroke patients with severe hand paresis from our previous study were invited, and 28 underwent follow-up assessments. Read More

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http://dx.doi.org/10.1177/1545968319827573DOI Listing
February 2019
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The Relationship between Diffusion-Weighted Magnetic Resonance Imaging Lesions and 24-Hour Rhythm Holter Findings in Patients with Cryptogenic Stroke.

Medicina (Kaunas) 2019 Feb 4;55(2). Epub 2019 Feb 4.

Department of Cardiology, School of Medicine, Trakya University, 22030 Edirne, Turkey.

Background And Objectives: Cranial magnetic resonance imaging findings of patients considered to be cryptogenic stroke may be useful in determining the clinical and prognostic significance of arrhythmias, such as atrial premature beats and atrial run attacks, that are frequently encountered in rhythm Holter analysis. This study was conducted to investigate the relationship between short atrial runs and frequent premature atrial contractions detected in Holter monitors and infarct distributions in cranial magnetic resonance imaging of patients diagnosed with cryptogenic stroke.

Materials And Methods: We enrolled the patients with acute ischemic stroke whose etiology were undetermined. Read More

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http://www.mdpi.com/1010-660X/55/2/38
Publisher Site
http://dx.doi.org/10.3390/medicina55020038DOI Listing
February 2019
3 Reads

Acupuncture Enhances Communication between Cortices with Damaged White Matters in Poststroke Motor Impairment.

Evid Based Complement Alternat Med 2019 2;2019:4245753. Epub 2019 Jan 2.

Department of Neurology and Stroke Center, Dongzhimen Hospital, The First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.

Stroke is a leading cause of motor disability. Acupuncture is an effective therapeutic strategy for poststroke motor impairment. However, its mechanism is still elusive. Read More

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http://dx.doi.org/10.1155/2019/4245753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334314PMC
January 2019
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Acute Iloprost Inhalation Improves Right Ventricle Function in Pulmonary Artery Hypertension: A Cardiac Magnetic Resonance Study.

Front Pharmacol 2018 21;9:1550. Epub 2019 Jan 21.

Tianjin Medical University General Hospital, Tianjin, China.

Right ventricle (RV) function is among the most important prognostic factors for pulmonary arterial hypertension (PAH) patients. Inhaled iloprost, an inhaled member of the prostacyclin family, is effective for the treatment of severe PAH and acute RV failure. However, the acute effects of iloprost on RV physiology have not been thoroughly explored in the past. Read More

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http://dx.doi.org/10.3389/fphar.2018.01550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348276PMC
January 2019
1 Read

The Influence of Stroke Location on Cognitive and Mood Impairment. A Voxel-Based Lesion-Symptom Mapping Study.

J Stroke Cerebrovasc Dis 2019 Feb 1. Epub 2019 Feb 1.

UMR-5287 CNRS, Université de Bordeaux, EPHE PSL Research University, Bordeaux, France; CHU de Bordeaux, Unité Neuro-vasculaire, Bordeaux, France. Electronic address:

Background And Purpose: The role of stroke location as a determinant of mood and cognitive symptoms is still a matter of debate. The aim of this study was to identify the predictive value of ischemic stroke location, on a voxel basis, for mood and cognitive outcome.

Materials And Methods: A prospective monocentric study including patients with a supratentorial ischemic stroke was conducted. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.010DOI Listing
February 2019

The inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: The chronnectome fingerprint.

Neuroimage 2019 Feb 1;189:645-654. Epub 2019 Feb 1.

Centre for Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address:

Frontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a "chronnectome" approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 472 at-risk FTD subjects from the Genetic Frontotemporal dementia research Initiative (GENFI) cohort. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.01.080DOI Listing
February 2019
1 Read
6.357 Impact Factor