49,429 results match your criteria Macular Hole
Prog Retin Eye Res 2018 Dec 12. Epub 2018 Dec 12.
Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
In the eye immune defenses must take place in a plethora of differing microenvironments ranging from the corneal and conjunctival epithelia facing the external environment to the pigmented connective tissue of the uveal tract containing smooth muscle, blood vessels and peripheral nerves to the innermost and highly protected neural retina. The extravascular environment of the neural retina, like the brain parenchyma, is stringently controlled to maintain conditions required for neural transmission. The unique physiological nature of the neural retina can be attributed to the blood retinal barriers (BRB) of the retinal vasculature and the retinal pigment epithelium, which both tightly regulate the transport of small molecules and restrict passage of cells and macromolecules from the circulation into the retina in a similar fashion to the blood brain barrier (BBB). Read More
Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.
Department of Medicine, the University of California, San Francisco, School of Medicine, San Francisco, CA, USA.
Purpose: To evaluate the relationships among age-related macular degeneration (AMD), mortality, and biomarkers of systemic inflammation in patients with the acquired immunodeficiency syndrome (AIDS).
Design: Case control study.
Participants: Participants with intermediate-stage AMD at enrollment in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) and 2:1 controls matched for age and gender. Read More
Int J Infect Dis 2018 Dec 11. Epub 2018 Dec 11.
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Background: Hand, foot and mouth disease (HFMD) has been associated with large outbreaks among young children, including severe illness and fatality, in the Asia-Pacific Region since 1997. Severe illness is often associated with enterovirus A71 (EV-A71). Vietnam experienced a large sustained outbreak of 200. Read More
IUBMB Life 2018 Dec 14. Epub 2018 Dec 14.
Vascular Biology Laboratory, JM USDA-HNRCA at Tufts University, Boston, Massachusetts.
α-Tocopherol is the only tocopherol that has been shown to prevent the human deficiency disease Ataxia with Isolated Vitamin E Deficiency (AVED), and thus it is the only one that, for humans, can be called vitamin E. Vitamin E in addition to preventing AVED has documented immune boosting properties and an activity against nonalcoholic hepatosteatosis and low-grade inflammation. Epidemiological studies indicating that vitamin E could prevent cardiovascular events, neurodegenerative disease, macular degeneration, and cancer were in general not confirmed by clinical intervention studies. Read More
Invest Ophthalmol Vis Sci 2018 Dec;59(15):5893-5903
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Purpose: To investigate the nonperfused areas (NPAs) in each subfield segmented by large arterioles on wide-field swept-source optical coherence tomography angiography (SS-OCTA) images in diabetic retinopathy.
Methods: We retrospectively reviewed 101 consecutive eyes of 67 patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR), for whom 12 × 12-mm SS-OCTA images centered on the optic disc were acquired. Both eyes were included in 34 patients. Read More
Retina 2018 Dec 13. Epub 2018 Dec 13.
Department of Ophthalmology, Eye and ENT Hospital, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea.
Purpose: To investigate the prevalence of pachydrusen, soft drusen, and subretinal drusenoid deposits in eyes with different neovascular age-related macular degeneration (nAMD) subtypes, determine the relationship between each drusen type and the choroidal thickness, and analyze the distinct features of each nAMD subtype according to the drusen type.
Methods: Medical records involving 454 eyes from 454 patients with nAMD were retrospectively reviewed. The prevalence of each drusen type and the choroidal thickness and choroidal characteristics were evaluated according to the nAMD subtype. Read More
Retina 2018 Dec 6. Epub 2018 Dec 6.
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
Purpose: To report visual and anatomical outcomes after the repair of chronic idiopathic macular holes (MHs) with no face-down positioning.
Methods: We conducted a retrospective review of chronic MH cases of greater than 1-year duration that were repaired through pars plana vitrectomy with broad internal limiting membrane peeling and no face-down positioning between March 2009 and December 2017. There were 18 eyes of 18 patients that met inclusion criteria. Read More
Retina 2018 Dec 6. Epub 2018 Dec 6.
Vitreous, Retina, Macula Consultants of New York, New York.
Purpose: To investigate the imaging characteristics of early Type 3 neovascularization and propose a new pathophysiologic sequence for early disease.
Methods: Patients were evaluated with a comprehensive ophthalmologic examination to include fundus photography, optical coherence tomography, optical coherence tomography angiography, fluorescein angiography, and volume-rendered optical coherence tomography angiography. Relevant literature was also reviewed. Read More
Retina 2018 Dec 6. Epub 2018 Dec 6.
Service d'Ophtalmologie, Hôpital Lariboisière, AP-HP, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Sorbonne Paris Cité, France.
Purpose: To provide values of retinal vessel density (VD) in the three retinal capillary plexuses, foveal avascular zone (FAZ) area, and retinal layer thickness in a cohort of healthy subjects.
Methods: The optical coherence tomography angiography maps of 148 eyes of 84 healthy subjects, aged 22 to 76 years, were analyzed for measuring VD of the retinal capillary plexuses, using the Optovue device comprising a projection artifact removal algorithm. Foveal avascular zone metrics were measured, and the relationship between optical coherence tomography angiography findings and age, sex, and image quality was studied. Read More
J Med Econ 2018 Dec 14:1-28. Epub 2018 Dec 14.
e Market Access, Health Economics and Outcomes Research , Bayer Yakuhin, Ltd , Tokyo , Japan.
Aims: To estimate the impact of anti-vascular endothelial growth factor (VEGF) agents on visual impairment and blindness avoided in patients with diabetic macular edema (DME) and on associated patient and caregiver productivity loss in Japan.
Methods: We compared the impact of current care (estimated at 53.8% utilization of anti-VEGF agents using current data) with that of hypothetical care (characterized by a higher utilization of anti-VEGF agents [80. Read More
Korean J Ophthalmol 2018 Dec;32(6):506-516
Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea.
Purpose: We measured the thicknesses of the ganglion cell and inner plexiform layer (GCIPL), the macula, and the retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography in patients with idiopathic macula holes to analyze the repeatability of these measurements and compare them with those of the fellow eye.
Methods: We evaluated 85 patients who visited our retinal clinic. The patients were divided into two groups according to their macular hole size: group A had a size of <400 μm, while group B had a size of ≥400 μm. Read More
Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Purpose: The aim of the study was to report prevalence, ocular outcome, neurological characteristics, cognitive and behavioural problems in children with optic disc coloboma (ODC).
Methods: This was a population-based, cross-sectional study of 31 children between 2 and 18 years of age diagnosed with ODC. The children were part of a larger cohort of 184 children with congenital optic disc malformations. Read More
Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.
Department of Ophthalmology, Odense University Hospital, Odense, Denmark.
Purpose: Non-invasive retinal markers of disease activity could pave the way for individualized treatment in neovascular age-related macular degeneration (nAMD). We aimed to evaluate if retinal vascular oxygen saturation and calibres could predict the initial treatment response after a loading phase of intravitreal aflibercept in nAMD.
Method: A total of 149 eyes were included (nAMD, n = 76; dry AMD, n = 30; normal eyes n = 43). Read More
Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.
Department of Ophthalmology and Optometry, Vienna Trial Center (VTC), Medical University of Vienna, Vienna, Austria.
Purpose: Quantification of fundus autofluorescence has only recently become available. We report our findings on the evaluation of the repeatability and reliability of quantitative fundus autofluorescence (qAF) measurements in patients with early and intermediate age-related macular degeneration (AMD), using the first approved and commercially available instrument.
Methods: A total of 43 eyes of 22 patients (aged between 52 and 84 years) diagnosed with early and intermediate AMD were included. Read More
J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
The retina is the neural portion and light-sensitive layer of the eye, which has been observed in most of the vertebrates. The retina is composed of light-sensitive cells that absorb light and convert it into neural signals. These signals are sent to the brain for visual recognition. Read More
BMC Ophthalmol 2018 Dec 14;18(1):322. Epub 2018 Dec 14.
Department of Ophthalmology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Background: This study aimed to investigate patient adherence to face-down positioning (FDP) and non-supine positioning (NSP) following vitrectomy with gas tamponade for treating macular holes (MHs).
Methods: Nursing records of 92 patients who underwent vitrectomy with gas tamponade for small-diameter (diameter < 400 μm) MHs during April 2016-June 2017 were examined. Forty-seven and 45 patients were instructed to maintain FDP and NSP (FDP and NSP groups), respectively. Read More
Graefes Arch Clin Exp Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.
Department of Ophthalmology and Vision Sciences, Princess Margaret Hospital/University Health Network, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.
Interferons are cytokines that regulate the host's response to viral infection, particularly in the setting of the immunologic response to the hepatitis C virus (HCV). While the virus has the ability to evade the host's innate and specific immunity, exogenous interferon-α with combined ribavirin, treatments have been found to achieve a significant sustained viral response in subgroups of patients with chronic HCV. One of the major side effects of interferon-α is an ocular retinopathy characterized by flame-shaped hemorrhages and cotton wool spots visualized on funduscopic examination. Read More
Ophthalmologe 2018 Dec 13. Epub 2018 Dec 13.
Eye (Lond) 2018 Dec 13. Epub 2018 Dec 13.
Department of Ophthalmology, Bolton Hospitals NHS Foundation Trust, Bolton, UK.
Objective: To explore self-inflicted retinal burns from laser pointers in children.
Methods: Literature review of laser pointer retinal injuries in childhood and online survey of UK Consultant Ophthalmologists. A cohort of local children with self-inflicted injury is described. Read More
BMC Ophthalmol 2018 Dec 13;18(1):321. Epub 2018 Dec 13.
Department of Ophthalmology, Eye and ENT Hospital, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Background: Changes in retinal fluid patterns associated with circumscribed choroidal hemangioma (CCH) have not been investigated yet. A long-term follow-up study was performed to evaluate the changes of retinal fluid patterns and treatment responses.
Methods: We retrospectively reviewed medical records of all CCH patients diagnosed between November 2005 and March 2017. Read More
Int J Vitam Nutr Res 2018 Dec 14:1-10. Epub 2018 Dec 14.
1 Luxembourg Institute of Health (LIH), Department of Population Health, Strassen, Luxembourg.
Carotenoids are C-30, C-40 or C-50 terpenoids produced by a number of bacteria, fungi, and plants. In addition to acting as vitamin A precursors such as β-carotene, their dietary intake and blood plasma/serum and tissue levels have been associated in several epidemiological studies to the reduced incidence of chronic diseases, including the reduction of type 2 diabetes and other cardiometabolic diseases, as well as some types of cancer. Lutein and zeaxanthin also appear to play a role in the amelioration of age-related macular degeneration (AMD), the main cause of blindness in the elderly, and may be regarded as conditionally essential nutrients for the elderly. Read More
Int J Environ Res Public Health 2018 Dec 10;15(12). Epub 2018 Dec 10.
Department of Dermatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
There have been many public health recommendations for avoiding UV radiation exposures. This is primarily due to concerns about skin cancer and especially melanoma, the most serious type of skin cancer. However, UV radiation is also known as the primary source of vitamin D and other compounds needed for good health. Read More
JAMA Oncol 2018 Dec 13. Epub 2018 Dec 13.
Department of Haematology, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, Scotland.
BMC Ophthalmol 2018 Dec 12;18(1):318. Epub 2018 Dec 12.
Department of Ophthalmology, Hainan General Hospital, Haikou, 570102, China.
Background: Doyne honeycomb retinal dystrophy (DHRD)/malattia leventinese (ML) is a rare allelic condition with massive drusen in the posterior fundus caused by EFEMP1 gene mutation. Patients showed decreased vision when the lesion affected the macular area. At present, the treatment efficiency is not satisfactory. Read More
Cesk Slov Oftalmol 2018 ;73(5-6):183-188
Purpose: functional and anatomical results after combination of intravitreal dexamethasone implant with anti-VEGF bevacizumab in macular edema secondary to retinal vein occlusion.
Methods: Retrospective analysis of 50 patients, average age 72 years, 15 men and 35 women. Inclusion criteria for treatment were retinal vein occlusion, best corrected visual acuity (BCVA) more than 20/200 and macular edema more than 250 μm. Read More
Cesk Slov Oftalmol 2018 ;73(5-6):171-177
Purpose: To evaluate OCT findings and long-term follow-up results in patient with optic disc pit (ODP) and associated maculopathy treated with pars plana vitrectomy (PPV).
Methods: Six eyes of 6 patients (3 females, 3 males) were included in a retrospective study. We excluded patients with ODP without maculopathy. Read More
Cesk Slov Oftalmol 2018 ;74(1):3-8
Progress in optical coherent tomography (OCT) has recently provided new insights into variety of chorioretinal disorders. The use of EDI (Enhanced Depth Imaging) during OCT examinations and as well as OCT angiography provides a more accurate analysis of the choroid both quantitatively and qualitatively. "Pachychoroid" (greek pachy- [παχύ] - thick) is defined as an abnormal and sustained increase in choroidal thickness 300 μm, which is mainly due to dilated choroidal vessels in the Hallers layer and other structural changes in physiological choroidal architecture. Read More
J Ophthalmol 2018 4;2018:8463569. Epub 2018 Nov 4.
Ophthalmology Unit, University Hospital of Parma, Parma, Italy.
Purpose: To compare the functional and clinical outcomes of the iris-claw intraocular lens (IOL) placed on the anterior versus posterior surface of the iris.
Patients And Methods: A multicenter, retrospective study. Data on eyes that underwent anterior or retropupillary iris-claw IOL implantation because of inadequate capsular support secondary to complicated cataract surgery, trauma, and dislocated/opacified IOLs since January 2015 were analyzed. Read More
J Ophthalmol 2018 6;2018:3470731. Epub 2018 Nov 6.
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Purpose: To evaluate logical surgical approaches to closing macular holes in eyes with proliferative diabetic retinopathy with retinal detachment.
Methods: Retrospective, interventional case series.
Results: 10 eyes in 10 patients were included in this study. Read More
Oxid Med Cell Longev 2018 5;2018:9248640. Epub 2018 Nov 5.
Schepens Eye Research Institute of Mass. Eye and Ear, Boston, MA 02114, USA.
Retinal pigment epithelium (RPE) dysfunction due to accumulation of reactive oxygen species and oxidative damage is a key event in the development of age-related macular degeneration (AMD). Here, we examine the therapeutic potential of ZLN005, a selective PGC-1 transcriptional regulator, in protecting RPE from cytotoxic oxidative damage. Gene expression analysis on ARPE-19 cells treated with ZLN005 shows robust upregulation of PGC-1 and its associated transcription factors, antioxidant enzymes, and mitochondrial genes. Read More
Oxid Med Cell Longev 2018 7;2018:4814928. Epub 2018 Nov 7.
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
The medicinal herb fruit has been widely used for improving and maintaining the health of the eyes in the Far East for many centuries. This study is aimed at investigating whether protective effects generated from the aqueous (LBA) and ethanol (LBE) extracts of the fruit existed against oxidative stress-induced apoptosis in human retinal pigment epithelial cells. extracts LBA and LBE exerted the activity of ROS scavenging and rescued UVB irradiation-induced growth inhibition in retinal pigment epithelial ARPE-19 cells. Read More
Neuroophthalmology 2018 Dec 5;42(6):402-403. Epub 2018 Feb 5.
Department of Haematology, Royal Free London Hospitals NHS Foundation Trust, London, UK.
Ocular features of Gaucher disease include gaze abnormalities, corneal clouding, ocular deposits and pigmentary changes in the macula. We report the presence of bilateral fovea sparing macular deposits in a 21-year-old woman with type 3 Gaucher disease. Macular deposits occur due to glucocerebroside accumulation within histiocytes and retinal deposits might correlate with the degree of systemic infiltration. Read More
Neuroophthalmology 2018 Dec 22;42(6):356-366. Epub 2018 May 22.
Department of Ophthalmology, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
The purpose of this study was to evaluate retinal thickness in different Xeroderma Pigmentosum (XP) complementation groups using spectral-domain optical coherence tomography (SD-OCT). This was a cross-sectional pilot study of 40 patients with XP. All patients had healthy-looking retinae and optic nerves on slit lamp biomicroscopy, and subtle or no neurological deficits. Read More
Br J Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.
Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea
Background/aims: To analyse intraocular pressure (IOP) changes over a period of 1 year after intravitreal dexamethasone (DEX, Ozurdex) implant injection and to compare the results with those of previously published studies that involved non-Asian populations.
Methods: A retrospective observational study was conducted. A total of 540 eyes of 503 patients who received DEX implant injection and were diagnosed with macular oedema (ME) due to various retinal diseases were examined. Read More
Diabetes Care 2018 Dec 6. Epub 2018 Dec 6.
Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Objective: The importance of renin-angiotensin-aldosterone system (RAAS) activation in retinopathy for long-standing diabetes is not well understood. We determined retinopathy stage and evaluated associations with other vascular complications before and after physiological RAAS activation in adults with long-standing (≥50 years duration) type 1 diabetes.
Research Design And Methods: Participants underwent retinal examination by digital funduscopic photography and optical coherence tomography and were classified as having nonproliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR), or no diabetic retinopathy (NDR) with or without diabetic macular edema (DME). Read More
Nutr Res 2018 Oct 28. Epub 2018 Oct 28.
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, IL; Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, IL. Electronic address:
Despite the growing awareness regarding lutein's putative roles in eyes and brain, its pharmacokinetics and tissue distribution in primates have been poorly understood. We hypothesized that C-lutein will be differentially distributed into tissues of an adult rhesus macaque (Macaca mulatta) 3 days following a single oral dose. After a year of prefeeding a diet supplemented with unlabeled lutein (1 μmol/kg/d), a 19-year-old female was dosed with 1. Read More
BMC Ophthalmol 2018 Dec 6;18(1):310. Epub 2018 Dec 6.
Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, #17 Haengdang-dong, Seongdong-gu, Seoul, 133-792, South Korea.
Background: Cystoid macular oedema (CMO) is an uncommon complication associated with hydroxychloroquine (HCQ) retinopathy threatening central vision. We report a patient with HCQ retinopathy and CMO, for which an intravitreal dexamethasone implant was used, which led to complete resolution of oedema.
Case Presentation: A 57-year-old woman with systemic lupus erythematosus (SLE) complaining of blurred vision in both eyes was diagnosed with bilateral HCQ retinopathy and CMO based on characteristic photoreceptor defects and cystoid spaces on optical coherence tomography, hypo-autofluorescence on fundus autofluorescence, and corresponding visual field defects. Read More
Eur J Ophthalmol 2018 Dec 12:1120672118812270. Epub 2018 Dec 12.
In-Patient Department 2, Affiliated Eye Hospital of Nanjing Medical University, Nanjing, China.
Purpose:: To compare the outcome of the sequence in the two treatments (intravitreal ranibizumab and panretinal photocoagulation) in high-risk proliferative diabetic retinopathy.
Methods:: This retrospective study included 35 patients with newly diagnosed high-risk proliferative diabetic retinopathy in 43 eyes; 18 (22 eyes) received intravitreal ranibizumab before panretinal photocoagulation (intravitreal ranibizumab+ group), while the other 17 (21 eyes) received panretinal photocoagulation before intravitreal ranibizumab (panretinal photocoagulation+ group). Each subject received three intravitreal ranibizumabs that were interleaved with three panretinal photocoagulations. Read More
Graefes Arch Clin Exp Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.
Department of Ophthalmology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China.
Purpose: To evaluate the effect of adenoidectomy on the brains of children with obstructive sleep apnea-hypopnea syndrome (OSAS) through observation of the alteration of retinal perfusion by optical coherence tomography angiography (OCTA).
Methods: Sixty-two children with OSAS (124 eyes; 5.94 ± 1. Read More
Ophthalmologe 2018 Dec 11. Epub 2018 Dec 11.
Augenklinik, Ludwig-Maximilians-Universität, Mathildenstr. 8, 80336, München, Deutschland.
Background: Corneal optical coherence tomography (anterior segment OCT, AS-OCT) is described in the current IC3D classification of corneal dystrophies to be a method for improvement of clinical diagnostics and treatment.
Objective: In this case series AS-OCT images of corneal dystrophies were analyzed with respect to morphological changes.
Material And Methods: This was a retrospective imaging and morphological case series with 38 eyes. Read More
BMJ Open Ophthalmol 2018 17;3(1):e000209. Epub 2018 Nov 17.
British Columbia Center for Epidemiology & International Ophthalmology and Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada.
Introduction: The only population-based survey of blindness and visual impairment of a Tibetan population was conducted in the Tibet Autonomous Region in 1999.
Methods And Analysis: The Rapid Assessment of Avoidable Blindness methodology was used to conduct a survey of Kandze Tibetan Autonomous Prefecture, Sichuan Province of China in the Fall 2017. Using the 2010 census, 100 clusters of 50 participants aged 50 years or older were randomly sampled using probability proportionate to size. Read More
BMJ Open Ophthalmol 2018 23;3(1):e000174. Epub 2018 Nov 23.
Dipartimento Neuromuscoloscheletrico e Organi di Sensi, Università degli Study di Firenze, Florence, Italy.
Objective: Intraocular lens (IOL) repositioning using a closed-eye approach could be carried out in some selected cases. Our study focuses on the efficacy and safety of a IOL closed-eye repositioning technique using scleral suture, which is performed using a trocar as an intrastromal limbal guide.
Methods And Analysis: Thirty-one eyes of 31 patients with late IOL dislocation operated on between January 2015 and May 2017 were included in this retrospective non-comparative consecutive case series study. Read More
J Ophthalmol 2018 13;2018:7361212. Epub 2018 Nov 13.
Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain.
Purpose: To evaluate the ability of new swept-source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with multiple sclerosis (MS).
Methods: A total of 101 healthy and 97 MS eyes underwent retinal and choroidal assessment using SS Triton OCT (Topcon). Macular thickness and peripapillary data (retinal, ganglion cell layer (GCL+, GCL++) and retinal nerve fiber layer (RNFL) thickness) were analyzed, including choroidal thickness evaluation. Read More
J Ophthalmol 2018 12;2018:7348153. Epub 2018 Nov 12.
Municipal Hospital of Qingdao City, Qingdao, China.
Purpose: To evaluate the correlative factors of best-corrected visual acuity (BCVA) with intravitreal conbercept injection in macular edema secondary to branch retinal vein occlusion (BRVO).
Methods: This is a self-controlled retrospective study. 35 eyes of 35 patients with macular edema secondary to BRVO were enrolled. Read More
J Ophthalmol 2018 12;2018:2353428. Epub 2018 Nov 12.
Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0114, Japan.
Purpose: To evaluate the effect of smoking on the outcome of antivascular endothelial growth factor (VEGF) therapy in patients with neovascular age-related macular degeneration (nAMD).
Methods: This retrospective case-control study included 64 eyes in 59 patients with treatment-naïve nAMD. Smoking habits were obtained from hospital records and patient recall. Read More
Clin Ophthalmol 2018 26;12:2383-2391. Epub 2018 Nov 26.
Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt.
Purpose: The purpose of this study was to evaluate the safety of high-dose intravitreal triamcinolone acetonide (IVTA) as affordable low-cost alternative to anti-vascular endothelial growth factor (anti-vascular endothelial growth factor [anti-VEGF] agents) in lower-middle-income countries.
Patients And Methods: This was a retrospective interventional non-comparative case series. The study recruited patients who received 20 mg IVTA for treating various retinal and optic nerve diseases over the past 5 years. Read More
Br J Ophthalmol 2018 Dec 11. Epub 2018 Dec 11.
Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Purpose: To evaluate vascular changes in patients with intermediate uveitis with or without retinal vasculitis using swept-source wide-field optical coherence tomography angiography (OCTA).
Methods: This is a prospective cross-sectional study. Consecutive patients with intermediate uveitis were evaluated using wide-field OCTA. Read More
Prog Retin Eye Res 2018 Dec 8. Epub 2018 Dec 8.
Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. Electronic address:
A posterior staphyloma is an outpouching of a circumscribed region of the posterior fundus and has been considered a hallmark of pathologic myopia. Occurring in highly myopic eyes, it is histologically characterized by a relatively abrupt scleral thinning starting at the staphyloma edge, a pronounced de-arrangement of scleral collagen fibrils and a marked choroidal thinning, which is the most marked at the staphyloma edge and which occurs in addition to the axial elongation-associated choroidal thinning. Besides in highly myopic eyes, a posterior staphyloma can be found in non-highly myopic eyes in association with retinitis pigmentosa or localized defects of Bruch's membrane in the cases of which it is not associated with a marked choroidal thinning. Read More