5,935 results match your criteria Macular Hole


Involvement of premacular mast cells in the pathogenesis of macular diseases.

PLoS One 2019 22;14(2):e0211438. Epub 2019 Feb 22.

Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.

We previously reported on the elevated intravitreal activities of tryptase and chymase in association with idiopathic epiretinal membrane (ERM) and idiopathic macular hole (MH). In this present study, we investigated the potential intraocular production of these serine proteases, and measured and compared tryptase and chymase activities in the vitreous body and serum in ERM, MH, proliferative diabetic retinopathy (PDR), and rhegmatogenous retinal detachment (RRD) patients. In addition, nuclear staining with hematoxylin and eosin (H&E) and mast-cell staining with toluidine blue were performed on samples of the vitreous core and bursa premacularis (BPM) of MH. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211438PLOS
February 2019

Preoperative prognostic factors for macular hole surgery: Which is better?

Oman J Ophthalmol 2019 Jan-Apr;12(1):20-24

Department of Ophthalmology, Istanbul Research and Education Hospital, Istanbul, Turkey.

Aim: This study aims to evaluate the prognostic factors of different optical coherence tomography (OCT) parameters as well as the tamponade used in surgery, on postoperative anatomical and functional success.

Methods: Twenty-nine eyes of 27 patients were included in this study. A three-port 23-gauge pars plana vitrectomy was performed on all eyes with peeling of the internal limiting membrane by visualization with brilliant blue dye by the same surgeon (E. Read More

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http://dx.doi.org/10.4103/ojo.OJO_247_2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380157PMC
February 2019

Treatment of macular hemorrhage in retinal arterial microaneurysm: anatomic site-oriented therapy.

Jpn J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, Nihon University Hospital, 1-6 Surugadai, Kanda, Chiyodaku, Tokyo, 101-8309, Japan.

Purpose: To investigate the usefulness of anatomic site-oriented therapy for macular hemorrhage secondary to retinal arterial macroaneurysm (RAM).

Study Design: Retrospective observational study, clinical case series METHODS: Twenty-seven consecutive patients (27 eyes) with macular hemorrhage secondary to RAM were classified according to the retinal layer(s) with hemorrhage identified by optical coherence tomography into 4 types and treated differentially. Vitrectomy was conducted for subinternal limiting membrane hemorrhage (SILMH), intravitreal gas injection for subretinal hemorrhage (SRH) or intraretinal hemorrhage (IRH), and vitrectomy and intravitreal air/gas exchange for multilevel hemorrhage (at least 2 among SILMH/SRH/IRH). Read More

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http://dx.doi.org/10.1007/s10384-019-00653-yDOI Listing
February 2019

Macular Hole Complicating Familial Exudative Vitreoretinopathy Due to LRP5 Mutation in an Adolescent.

Ophthalmic Surg Lasers Imaging Retina 2019 Feb;50(2):e49-e51

A 17-year-old boy, previously diagnosed with familial exudative vitreoretinopathy (FEVR) due to LRP5 mutation, complained of left eye decreased vision. Serial imaging by optical coherence tomography showed vitreomacular traction that progressed to lamellar macular hole (MH), and further evolved to full-thickness MH 3 weeks later. Visual acuity (VA) was 20/200. Read More

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http://dx.doi.org/10.3928/23258160-20190129-19DOI Listing
February 2019

Topical Aqueous Suppression and Closure of Idiopathic Full-Thickness Macular Holes.

Ophthalmic Surg Lasers Imaging Retina 2019 Feb;50(2):e38-e43

Hydration of retinal tissue has been proposed as a potential model of macular hole (MH) formation in addition to tractional forces of the vitreous and internal limiting membrane (ILM). Carbonic anhydrase inhibitors have previously been utilized in the treatment of cystoid macular edema in outer retinal diseases. There has been recent interest in the use of topical aqueous suppression as a potential medical therapy for MHs. Read More

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http://dx.doi.org/10.3928/23258160-20190129-17DOI Listing
February 2019

Current Management of Macular Hole.

Ophthalmic Surg Lasers Imaging Retina 2019 Feb;50(2):61-68

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http://dx.doi.org/10.3928/23258160-20190129-01DOI Listing
February 2019

Delayed spontaneous closure of blue laser-induced full thickness macular hole.

Am J Ophthalmol Case Rep 2019 Mar 9;13:154-156. Epub 2019 Jan 9.

Lebanese American University, Beirut, Lebanon.

Purpose: To report a blue laser-induced full thickness macular hole (FTMH) with delayed spontaneous closure without surgical intervention.

Observations: A 14-year old male developed full thickness macular hole after momentary exposure to a high-power handheld blue laser device. The macular hole closed spontaneously over a long period of observation. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351355PMC

Inverted Internal Limiting Membrane Technique Maintains Macular Hole Closure in Retinal Detachment Following Macular Hole Repair.

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):167-169

Retina Institute, Eye Foundation Hospitals, Lagos, Nigeria.

Recent advances in macular hole surgery have significantly improved the rates of anatomical success. One important advance is the dye-assisted peeling of the internal limiting membrane (ILM) around the hole. In large holes (<400 μ), sometimes, ILM peeling alone is not enough to achieve closure, and this may be improved by inverting part of the peeled membrane and using it to cover the macular hole or inverting and tucking the ILM flap into the hole. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_354_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348937PMC
February 2019

A Heart-Shaped Fovea After Macular Hole Repair.

JAMA Ophthalmol 2019 Feb 14;137(2):e185820. Epub 2019 Feb 14.

Clinique Jules Verne, Institut Ophtalmologique de l'Ouest, Nantes, France.

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http://dx.doi.org/10.1001/jamaophthalmol.2018.5820DOI Listing
February 2019

Bilateral Acute Angle-Closure Glaucoma after Macular Hole Surgery.

Korean J Ophthalmol 2019 Feb;33(1):101-102

Department of Ophthalmology, Keimyung University School of Medicine, Daegu, Korea.

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http://dx.doi.org/10.3341/kjo.2018.0061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372387PMC
February 2019

Predictive Model for Macular Hole Closure Speed: Insights From Intraoperative Optical Coherence Tomography.

Transl Vis Sci Technol 2019 Jan 6;8(1):18. Epub 2019 Feb 6.

The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.

Purpose: To establish a predictive model of macular hole (MH) closure speed.

Methods: This study was a post hoc analysis of eyes that underwent full-thickness MH repair in the prospective PIONEER intraoperative optical coherence tomography (iOCT) study. The Bioptigen SDOIS system was used for iOCT imaging. Read More

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http://dx.doi.org/10.1167/tvst.8.1.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366005PMC
January 2019

A Double Inverted Flap Surgical Technique for the Treatment of Idiopathic Lamellar Macular Hole Associated with Atypical Epiretinal Membrane.

Ophthalmologica 2019 Feb 8:1-10. Epub 2019 Feb 8.

Department of Ophthalmology, University of Padova, Padova, Italy.

Objectives: To propose a new technique of a double inverted epiretinal membrane (ERM) and internal limiting membrane (ILM) flap (double flap group) for the treatment of idiopathic lamellar macular hole (LMH) with atypical ERM (AERM) and to compare surgical outcomes to those of the standard technique of ERM and ILM peeling of the fovea including LMH (control group).

Methods: AERM was tomographically defined as a medium reflective thickened membrane above the retinal fiber layers without retinal traction signs. A series of patients affected by LMH with AERM were recruited. Read More

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http://dx.doi.org/10.1159/000496297DOI Listing
February 2019

Effect of Ocriplasmin on objectively assessed retinal function after treatment of vitreomacular diseases.

Acta Ophthalmol 2019 Feb 7. Epub 2019 Feb 7.

Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.

Background: The scope of the study was the functional assessment of possible effects of intravitreally injected ocriplasmin using electroretinographical (ERG) examinations.

Methods: Seven subjects suffered from pathologies within the label of ocriplasmin (Jetrea ) were examined in the study. An extended international society for clinical electrophysiology of vision ERG protocol was used for baseline recordings (before treatment) and was repeated for comparison 3 months after treatment with intravitreally injected ocriplasmin. Read More

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http://dx.doi.org/10.1111/aos.14030DOI Listing
February 2019

Impact of automated OCT in a high-volume eye urgent care setting.

BMJ Open Ophthalmol 2019 20;4(1):e000187. Epub 2019 Jan 20.

Department of Ophthalmology, New York Eye and Ear Infirmary of Mt. Sinai, New York City, New York, USA.

Background/aims: Optical coherence tomography (OCT) has become standard of care in the diagnosis and management of a myriad of retinal and optic nerve pathology. Access to diagnostic equipment and skilled imaging personnel in the after-hours setting is often limited. We examined the utility and diagnostic indications for automated OCT in a high-volume after-hours clinic within an eye institute. Read More

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http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
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http://dx.doi.org/10.1136/bmjophth-2018-000187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340595PMC
January 2019
4 Reads

Autologous Retinal Transplant For Refractory Macular Holes: Multicenter International Collaborative Study Group.

Ophthalmology 2019 Jan 31. Epub 2019 Jan 31.

Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Associated Retinal Consultants, Royal Oak, MI.

Purpose: To report the structural and functional outcomes of the autologous neurosensory retinal transplant for closure of refractory large macular holes.

Design: Multicenter retrospective consecutive case series PARTICIPANTS: Forty-one eyes of 41 patients (27 female and 14 male) with a full thickness macular hole refractory to prior vitrectomy with internal limiting membrane peel and tamponade.

Methods: All patients underwent pars-plana vitrectomy, autologous neurosensory retinal transplant with either gas, silicone oil tamponade, or short-term Perfluoro-n-octane heavy-liquid tamponade. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.027DOI Listing
January 2019
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Spontaneous resolution of myopic foveoschisis and a macular hole with retinal detachment.

Am J Ophthalmol Case Rep 2019 Mar 9;13:143-146. Epub 2019 Jan 9.

Miyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, Miyazaki, 885-0051, Japan.

Purpose: The aim of this report was to describe a case of myopic foveoschisis and a macular hole with retinal detachment that resolved spontaneously.

Observations: A 62-year-old woman with bilateral blurred vision was referred to our department. Her best-corrected visual acuity (BCVA) was 0. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348488PMC

Incidence and prevalence of vitreomacular traction with and without macular hole in Germany.

Clin Ophthalmol 2019 15;13:177-188. Epub 2019 Jan 15.

Department of Ophthalmology, Faculty of Life Course Sciences and Medicine, King's College London, London, UK.

Purpose: Symptomatic vitreomacular adhesion (sVMA) comprises vitreomacular traction (VMT) and stage 1 and 2 full-thickness macular holes (MHs) associated with vitreomacular adhesion (VMA). We aimed to estimate the incidence and prevalence of sVMA in Germany.

Materials And Methods: A systematic literature review was conducted to identify the incidence and prevalence of sVMA based on international epidemiologic studies, weighted for study size and then averaged across eligible studies. Read More

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http://dx.doi.org/10.2147/OPTH.S188704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339449PMC
January 2019

Comparison of face-down posturing with nonsupine posturing after macular hole surgery: a meta-analysis.

BMC Ophthalmol 2019 Jan 28;19(1):34. Epub 2019 Jan 28.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Background: A few randomized controlled trials (RCTs) have evaluated face-down posturing (FDP) with the far less physically challenging nonsupine posturing (NSP) in the treatment of idiopathic full-thickness macular holes (MHs). The objective of our study was to evaluate the efficacy of postoperative posturing on the anatomical and functional outcomes of MH surgery.

Methods: The PubMed, Embase, and Cochrane Central Register of Controlled Trials databases were searched from their earliest entries through December 2016 to identify the studies that had evaluated the effects of postoperative posturing with FDP or NSP for patients with MH surgery. Read More

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http://dx.doi.org/10.1186/s12886-019-1047-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348675PMC
January 2019

Rhegmatogenous retinal detachment with a giant tear located in the intermediate periphery: Two case reports.

Medicine (Baltimore) 2019 Jan;98(4):e14271

Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.

Rationale: We experienced 2 cases of retinal detachment (RD) with giant tears located in the intermediate periphery of the fundus. In this case report, we investigated the clinical characteristics in these 2 cases.

Patient Concerns And Diagnoses: Case 1 involved a 63-year-old male, who became aware of metamorphopsia and decreased visual acuity (VA) in his left eye. Read More

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http://dx.doi.org/10.1097/MD.0000000000014271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358349PMC
January 2019
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Retinal inflammation diagnosed as an idiopathic macular hole with multiple recurrences and spontaneous closures: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14230

Department of Ophthalmology, Keio University, School of Medicine, 35 Shinanomachi, Shinjukuku.

Rationale: An idiopathic macular hole that causes substantial reduction in central visual acuity is believed to involve no obvious underlying diseases; thus, it is suspected to form due to the presence of idiopathic tractional forces at the vitreoretinal interface. Importantly, it is effectively treated with pars plana vitrectomy (PPV), which removes the mechanical forces. However, while it is exceedingly rare, a macular hole can develop in eyes after PPV; fresh or postoperative macular holes can close spontaneously without surgical removal of traction. Read More

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http://dx.doi.org/10.1097/MD.0000000000014230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358394PMC
January 2019
1 Read

Five-year nationwide incidence of macular hole requiring surgery in Korea.

Br J Ophthalmol 2019 Jan 23. Epub 2019 Jan 23.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea

Background/aims: To estimate the incidence and demographics of macular hole (MH) requiring surgery in Korea.

Methods: Patients who underwent surgery for MH in Korea from 2011 to 2015 with the diagnostic code for MH and the surgical code for vitrectomy were retrospectively identified using the Korean national health claims database. The average incidence rate of MH during the 5-year study period was estimated by applying the direct method of standardisation using the 2015 census data as a reference population. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313237DOI Listing
January 2019

Learning curve of three-dimensional heads-up vitreoretinal surgery for treating macular holes: a prospective study.

Int Ophthalmol 2019 Jan 23. Epub 2019 Jan 23.

Department of Ophthalmology-Retina, Federal University of São Paulo, Alameda Santos, 333 - Apto 142, São Paulo, SP, CEP 01419-000, Brazil.

Purposes: To compare surgeons' opinions regarding idiopathic full-thickness macular hole (MH) surgery by using traditional microscopy and three-dimensional (3-D) visualization system. To analyze the required time for pars plana vitrectomy (PPV) and for internal limiting membrane (ILM) rhexis by using both visualization methods. To evaluate anatomical surgical results. Read More

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http://dx.doi.org/10.1007/s10792-019-01075-yDOI Listing
January 2019
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[Results of pars plana vitrectomy with peeling of the inner limiting membrane in patients with laser-induced macular hole].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(48):3941-3945

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

To evaluate the results of pars plana vitrectomy (PPV) with peeling of the inner limiting membrane (ILM) in patients with laser-induced macular hole. The clinical data of 11 patients (12 eyes) with decreased visual acuity due to laser-induced macular hole from January 2014 to December 2017 were retrospectively studied.All patients underwent routine examination, fundus photography and optical coherence tomography (OCT). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.48.007DOI Listing
December 2018

Differential expression of connective tissue growth factor and hepatocyte growth factor in the vitreous of patients with high myopia versus vitreomacular interface disease.

BMC Ophthalmol 2019 Jan 21;19(1):25. Epub 2019 Jan 21.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.

Background: To determine the levels of connective tissue growth factor (CTGF) and hepatocyte growth factor (HGF) in the vitreous of patients with high myopia, in comparison with those with a vitreomacular interface disease (VMID).

Methods: Patients with either high myopia (high myopia group) or a VMID (VMID group) were included in this study. Each of the two groups were further subdivided into two subgroups: group A (high myopia with macular hole), group B (high myopia with macular retinoschisis), group C (idiopathic macular hole), and group D (idiopathic epiretinal membrane). Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
Publisher Site
http://dx.doi.org/10.1186/s12886-019-1041-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341692PMC
January 2019
4 Reads

DEVELOPMENT OF IDIOPATHIC MACULAR HOLE IN FELLOW EYES: Spectral Domain Optical Coherence Tomography Features.

Retina 2019 Jan 3. Epub 2019 Jan 3.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Purpose: To investigate the long-term incidence and risk factors of macular hole (MH) development in the fellow eyes of patients with unilateral idiopathic MH.

Methods: The retrospective case-control study involved the fellow eyes of 215 consecutive patients with idiopathic MH. The patients were classified into two groups according to the presence or development of MH in the fellow eye. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002439DOI Listing
January 2019
1 Read

Lamellar macular hole surgery - current concepts, future prospects.

Clin Ophthalmol 2019 8;13:143-146. Epub 2019 Jan 8.

Retina Division, Stein Eye Institute, University of California Los Angeles, Los Angeles, CA, USA.

Lamellar macular holes present distinct morphological features including tractional or non-tractional epimacular membranes, foveal tissue alterations, defects of the outer retinal layers, or a separation of the retinal layers. At present, degenerative lamellar holes are differentiated from tractional holes based on the morphological characteristics seen in OCT. The current treatment approach is based on this gross differentiation. Read More

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http://dx.doi.org/10.2147/OPTH.S188309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329342PMC
January 2019
2 Reads

Combined phacoemulsification, 23-gauge pars plana vitrectomy with internal limiting membrane peeling and gas tamponade for patients with coexisting idiopathic macular hole and age-associated cataract.

Exp Ther Med 2019 Jan 13;17(1):525-530. Epub 2018 Nov 13.

Department of Ophthalmology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China.

The aim of the present study was to assess the curative effect of combined phacoemulsification, 23-gauge pars plana vitrectomy with Brilliant blue G-assisted limiting membrane peeling and gas tamponade in patients with coexisting idiopathic macular hole (IMH) and age-associated cataract. A total of 21 consecutive patients (21 eyes) with coexisting IMH and age-associated cataract were enrolled in the study. All patients were treated by 23-gauge microincision vitrectomy with internal limiting membrane peeling, gas tamponade and combined phacoemulsification. Read More

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http://dx.doi.org/10.3892/etm.2018.6963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307372PMC
January 2019

Postoperative Adverse Events, Interventions, and the Utility of Routine Follow-Up After 23-, 25-, and 27-Gauge Pars Plana Vitrectomy.

Asia Pac J Ophthalmol (Phila) 2019 Jan 10. Epub 2019 Jan 10.

Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, United States.

Purpose: To evaluate the utility of standard postoperative visit (POV) intervals in pars plana vitrectomy (PPV) as a function of adverse events (AEs) identified.

Design: Retrospective case review.

Methods: The medical records of all patients undergoing 23-, 25-, and 27-gauge PPV from January 1, 2016 to December 31, 2016 were reviewed. Read More

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http://dx.doi.org/10.22608/APO.2018398DOI Listing
January 2019
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A Combination of Surgical Techniques to Repair a Giant Traumatic Macular Hole.

Case Rep Ophthalmol Med 2018 9;2018:7595873. Epub 2018 Dec 9.

Birmingham Midlands Eye Centre, Sandwell and West Birmingham Hospitals NHS Trust, Dudley Road, Birmingham B18 7QH, UK.

A 38-year-old man with a traumatic full-thickness macular hole (FTMH) presented to our eye casualty department with a sudden deterioration of his right eye vision to hand movements over the past one week. The suspected traumatic FTMH was present since he was 13 years old from a direct impact of a golf ball in his right eye and his best-corrected visual acuity (BCVA) has always remained at 1/60 Snellen vision. On examination, he had a very large FTMH measuring 1635 with central foveal retinal detachment. Read More

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http://dx.doi.org/10.1155/2018/7595873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304587PMC
December 2018

Lamellar Macular Hole: State of the Art.

Ophthalmic Res 2019 9;61(2):73-82. Epub 2019 Jan 9.

Department of Ophthalmology, University of Padua, Padua, Italy.

Lamellar macular hole (LMH) is a vitreoretinal disorder characterized by an irregular foveal contour, a break in the inner fovea, dehiscence of the inner foveal retina from the outer retina, and the absence of a full-thickness foveal defect with intact foveal photoreceptors. The pathogenesis is only partially known. The advent of high-resolution optical coherence tomography has allowed distinguishing between two types of epiretinal membrane (ERM) associated with LMH: a conventional ERM (commonly found in macular pucker) and an atypical ERM (known by varied names: dense, epiretinal proliferation, or degenerative). Read More

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http://dx.doi.org/10.1159/000494687DOI Listing
January 2019
2 Reads

Topical steroids: A non-surgical approach for recurrent macular holes.

Am J Ophthalmol Case Rep 2019 Mar 18;13:93-95. Epub 2018 Dec 18.

Department of Ophthalmology, University of Toronto, St. Michael's Hospital, Toronto, Canada.

Purpose: Report a case of a recurrent macular hole which completely resolved with a non-surgical approach with steroid drops.

Observations: While traction is considered the mayor contributor to full thickness macular hole formation, retinal hydration as that in cystoid macular edema also plays an important role.

Conclusions And Importance: Topical corticosteroid drops can be considered as an alternative therapy for small recurrent macular holes that lack tractional components and have an appearance of cystoid changes on the edges of the hole. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305691PMC

Deep Learning-Based Automated Classification of Multi-Categorical Abnormalities From Optical Coherence Tomography Images.

Transl Vis Sci Technol 2018 Nov 28;7(6):41. Epub 2018 Dec 28.

Eye Center, Renmin Hospital of Wuhan University, Eye Institute of Wuhan University, Wuhan, Hubei, China.

Purpose: To develop a new intelligent system based on deep learning for automatically optical coherence tomography (OCT) images categorization.

Methods: A total of 60,407 OCT images were labeled by 17 licensed retinal experts and 25,134 images were included. One hundred one-layer convolutional neural networks (ResNet) were trained for the categorization. Read More

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http://dx.doi.org/10.1167/tvst.7.6.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314222PMC
November 2018

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.

J Mol Med (Berl) 2019 Jan 7. Epub 2019 Jan 7.

MediCity Research Laboratory, University of Turku, Tykistökatu 6A, 20520, Turku, Finland.

ATP and adenosine are important signaling molecules involved in vascular remodeling, retinal function, and neurovascular coupling in the eye. Current knowledge on enzymatic pathways governing the duration and magnitude of ocular purinergic signaling is incompletely understood. By employing sensitive analytical assays, this study dissected ocular purine homeostasis as a complex and coordinated network. Read More

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http://dx.doi.org/10.1007/s00109-018-01734-0DOI Listing
January 2019
2 Reads

LONG-TERM RESULTS OF AUTOLOGOUS RETINAL PIGMENT EPITHELIUM AND CHOROID TRANSPLANTATION FOR THE TREATMENT OF EXUDATIVE AND ATROPHIC MACULOPATHIES.

Retina 2018 Dec 31. Epub 2018 Dec 31.

Department of Ophthalmology, University of Padova, Padova, Italy.

Purpose: To evaluate the long-term results of autologous retinal pigment epithelium (RPE) and choroid transplantation (RPE-choroid patch) for exudative and atrophic maculopathies.

Methods: Consecutive chart review of 120 eyes, which underwent RPE-choroid patch, from 2007 to 2017 for RPE atrophy or choroidal neovascular membrane secondary to exudative and hemorrhagic age-related macular degeneration, myopia, angioid streaks, and laser. Eyes were tested with best-corrected visual acuity (BCVA), reading ability, optical coherence tomography, fluorescein angiography and indocyanine green angiography, autofluorescence, and microperimetry. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002429DOI Listing
December 2018
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NECROSIS OF THE RETINA AND UVEAL TRACT SECONDARY TO EXPANDING GAS TAMPONADE.

Retin Cases Brief Rep 2018 Dec 27. Epub 2018 Dec 27.

Retina Specialists of Alabama, Birmingham, Alabama.

Purpose: To present a case of retinal and uveal necrosis caused by expanding gas tamponade after pars plana vitrectomy.

Methods: Single case report.

Results: An otherwise healthy 66-year-old woman underwent pars plana vitrectomy with intended 20% sulfur hexafluoride (SF6) tamponade for macular hole repair of her pseudophakic left eye. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000841DOI Listing
December 2018
1 Read

Long-Term Anatomic and Functional Outcomes after Macular Hole Surgery.

J Ophthalmol 2018 26;2018:3082194. Epub 2018 Nov 26.

Department of Ophthalmology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum, Bydgoszcz, Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.

Aim: To evaluate the structural and functional outcomes in patients who underwent macular hole (MH) surgery in the long-term follow-up.

Materials And Methods: Forty-four eyes of 40 patients (28 females and 12 males) were examined. The examination included visual acuity, optical coherence tomography, and colour vision testing. Read More

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http://dx.doi.org/10.1155/2018/3082194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287145PMC
November 2018
1 Read

Effect of intravitreal CF gas in patients with vitreomacular traction: A retrospective case series.

Spektrum Augenheilkd 2018 11;32(6):228-238. Epub 2017 Dec 11.

Department of Ophthalmology, Medical University of Graz, Auenbruggerplatz 4, 8036 Graz, Austria.

Background: We aimed to assess the efficacy of a single intravitreal perfluoropropane (CF) gas injection for the treatment of vitreomacular traction with or without a macular hole.

Methods: In this retrospective case series, seven eyes of six patients with symptomatic vitreomacular traction documented on optical coherence tomography, one with a macular hole additionally, received a single intravitreal CF gas injection of up to 0.3 ml. Read More

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http://dx.doi.org/10.1007/s00717-017-0382-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280806PMC
December 2017

[Prognostic factors for idiopathic macular hole surgery: Report of 107 eyes (Approach by univariate statistical analysis)].

J Fr Ophtalmol 2019 Feb 26;42(2):153-158. Epub 2018 Dec 26.

Service d'ophtalmologie, hôpital Émile-Muller, GHR Mulhouse Sud Alsace, 68100 Mulhouse, France.

Purpose: To identify prognostic factors influencing the success of idiopathic macular hole surgery, including initial visual acuity, hole size and stage, and type of gas used for tamponade.

Patients And Methods: Retrospective single-center descriptive analysis of all patients with an idiopathic macular hole operated by the same surgeon, treated in the ophthalmology department of Mulhouse hospital, between January 2004 and July 2014. Patients whose functional and anatomical results could be confounded by the coexistence of other ocular pathologies and patients with secondary macular holes were excluded. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01815512183044
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http://dx.doi.org/10.1016/j.jfo.2018.05.010DOI Listing
February 2019
1 Read

The role of endocrine disruptors in ocular surface diseases.

Med Hypotheses 2019 Jan 22;122:157-164. Epub 2018 Nov 22.

Department of Ophthalmology, Otorhinolaryngology and Head & Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo University of São Paulo, Ribeirão Preto, Sao Paulo, Brazil. Electronic address:

Endocrine disruptors are a group of compounds that occur in increasing amounts in the environment. These compounds change the hormone homeostasis of the target organs regulated by those hormones, mostly by binding to their receptors and affecting their signaling pathways. Among the hormones altered by endocrine disruptors are sex hormones, thyroid hormones, and insulin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183088
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http://dx.doi.org/10.1016/j.mehy.2018.11.009DOI Listing
January 2019
7 Reads

Spontaneous closure of a chronic full thickness macular hole after failed surgery.

Am J Ophthalmol Case Rep 2019 Mar 5;13:59-61. Epub 2018 Dec 5.

Retina Service, Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Purpose: To describe an unusual case of spontaneous closure of a chronic, large, idiopathic, stage 4 macular hole after failed surgery.

Observations: A 75-year-old female presented with a history of a chronic, full thickness macular hole after failed surgery in the right eye. Two years after onset, she developed a fibrotic scar, which closed the macular hole and unexpectedly improved her vision. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292999PMC

MORPHOLOGICAL CHARACTERISTICS AND VISUAL ACUITY OF HIGHLY MYOPIC EYES WITH DIFFERENT SEVERITIES OF MYOPIC MACULOPATHY.

Retina 2018 Dec 18. Epub 2018 Dec 18.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: To investigate the morphological feature, visual acuity, and prevalence of macular complications in highly myopic eyes with different categories of myopic maculopathy (MM) according to the META-PM classification system.

Methods: The clinical records of 1,132 consecutive patients (1,841 eyes) with high myopia (refractive error ≤ -6D and axial length ≥26.5 mm), who visited the High Myopia Clinic at the Zhongshan Ophthalmic Center from January 2014 to July 2017, were reviewed. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002418DOI Listing
December 2018
2 Reads

Macular Hole Formation After Pars Plana Vitrectomy for Diabetic Tractional Retinal Detachment.

Ophthalmic Surg Lasers Imaging Retina 2018 Dec;49(12):e256-e262

Background And Objective: To investigate the incidence, clinical features, and outcomes of patients with macular hole (MH) formation after pars plana vitrectomy (PPV) for diabetic tractional retinal detachment (TRD).

Patients And Methods: We conducted a retrospective review of all cases of PPV for diabetic TRD performed by a surgeon (DS) at a large county hospital between November 2013 and August 2016.

Results: Ninety consecutive eyes of 79 patients were included in this case series, of which four eyes developed MH, yielding an incidence of 4. Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2018
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http://dx.doi.org/10.3928/23258160-20181203-16DOI Listing
December 2018
4 Reads

Updated Cost-Effectiveness of Intravitreal Ocriplasmin for Vitreomacular Adhesion and Macular Hole.

Ophthalmic Surg Lasers Imaging Retina 2018 Dec;49(12):e240-e248

Background And Objective: The purpose of this study is to provide an updated assessment of cost-efficacy of intravitreal ocriplasmin (IVO) for vitreomacular adhesion (VMA) and macular holes (MH).

Patients And Methods: This was a single-center, multiple-physician, institutional review board-approved, retrospective, 15-month cost-effectiveness analysis study (January 2015 to April 2016). Clinical charts and billing records of 247 patients with VMA and MH were reviewed. Read More

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http://dx.doi.org/10.3928/23258160-20181203-14DOI Listing
December 2018

Comparison of Surgical Performance of Internal Limiting Membrane Peeling Using a 3-D Visualization System With Conventional Microscope.

Ophthalmic Surg Lasers Imaging Retina 2018 Dec;49(12):941-945

Background And Objective: To compare the surgical performance of internal limiting membrane (ILM) peeling in idiopathic macular hole using a digitally assisted vitreoretinal system (DAVS) and an analog microscope (AM).

Patients And Methods: Patients were operated on using an AM (Group A) and a DAVS (Group B). The data analyzed included surgical time required to complete ILM peeling, number of attempts to create ILM flap and complete ILM peeling, and intraoperative complications. Read More

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http://dx.doi.org/10.3928/23258160-20181203-06DOI Listing
December 2018
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LINCOFF RULES ARE NOT FOLLOWED IN RETINAL DETACHMENT WITH POSTERIOR BREAKS AND ATTACHED CORTICAL VITREOUS.

Retin Cases Brief Rep 2019 Winter;13(1):21-24

Vitreo Retina Services, Dr RP Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.

Purpose: 1) To evaluate factors governing flow of subretinal fluid and validate Lincoff rules (LRs) in cases of rhegmatogenous retinal detachment. 2) To identify cases of rhegmatogenous retinal detachment where LRs are not followed.

Method: This was a retrospective study where 253 patients of rhegmatogenous retinal detachment were identified through surgery records. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000522DOI Listing
February 2019

Cytokine profiles of phakic and pseudophakic eyes with primary retinal detachment.

Acta Ophthalmol 2018 Dec 18. Epub 2018 Dec 18.

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Purpose: To compare the cytokine profiles of phakic (p) and pseudophakic (ps) eyes with primary rhegmatogenous retinal detachment (RD) to eyes with macular holes (MH) and to identify differences in the specific cytokine profiles.

Methods: Aqueous humour (AH) and vitreous fluid (VF) were obtained from patients with primary RD without proliferative vitreoretinopathy undergoing vitrectomy. AH and VF of patients with macular holes (MH) served as controls. Read More

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http://doi.wiley.com/10.1111/aos.13998
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http://dx.doi.org/10.1111/aos.13998DOI Listing
December 2018
8 Reads

Ability of MultiColor scanning laser ophthalmoscope to detect non-glaucomatous retinal nerve fiber layer defects in eyes with retinal diseases.

BMC Ophthalmol 2018 Dec 17;18(1):324. Epub 2018 Dec 17.

Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.

Purpose: To compare the ability of ocular fundus images obtained by Spectralis MultiColor scanning laser ophthalmoscope (MC-SLO) to that obtained by conventional color fundus images (CF) in detecting non-glaucomatous nerve fiber layer defects (NFLDs).

Methods: A cross-sectional, retrospective study. Patients with retinal diseases who had ocular examination with both the MC-SLO and CF instruments at the Kagoshima University from December 2016 to February 2017 were studied. Read More

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http://dx.doi.org/10.1186/s12886-018-0995-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296147PMC
December 2018
2 Reads

NO FACE-DOWN POSITIONING SURGERY FOR THE REPAIR OF CHRONIC IDIOPATHIC MACULAR HOLES.

Retina 2018 Dec 6. Epub 2018 Dec 6.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.

Purpose: To report visual and anatomical outcomes after the repair of chronic idiopathic macular holes (MHs) with no face-down positioning.

Methods: We conducted a retrospective review of chronic MH cases of greater than 1-year duration that were repaired through pars plana vitrectomy with broad internal limiting membrane peeling and no face-down positioning between March 2009 and December 2017. There were 18 eyes of 18 patients that met inclusion criteria. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002396DOI Listing
December 2018
10 Reads
3.243 Impact Factor

Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell-inner Plexiform Layer in the Macular Hole: The Repeatability Study of Spectral-domain Optical Coherence Tomography.

Korean J Ophthalmol 2018 Dec;32(6):506-516

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea.

Purpose: We measured the thicknesses of the ganglion cell and inner plexiform layer (GCIPL), the macula, and the retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography in patients with idiopathic macula holes to analyze the repeatability of these measurements and compare them with those of the fellow eye.

Methods: We evaluated 85 patients who visited our retinal clinic. The patients were divided into two groups according to their macular hole size: group A had a size of <400 μm, while group B had a size of ≥400 μm. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3341/kjo.2018.00
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http://dx.doi.org/10.3341/kjo.2018.0030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288014PMC
December 2018
13 Reads