7,332 results match your criteria Macular Hole

Vitreomacular Interface Disorders in Proliferative Diabetic Retinopathy: An Optical Coherence Tomography Study.

J Clin Med 2022 Jun 7;11(12). Epub 2022 Jun 7.

Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou 515041, China.

Vitreomacular interface plays an important role in the pathogenesis and progression of proliferative diabetic retinopathy (PDR). This study investigated the prevalence and risk factors of vitreomacular interface disorders (VMID) in PDR. The macular optical coherence tomography (OCT) scans of 493 eyes from 378 PDR patients were retrospectively reviewed to detect VMID, including vitreomacular adhesion (VMA), vitreomacular traction (VMT), epiretinal membrane (ERM), lamellar hole-associated epiretinal proliferation (LHEP), and macular hole (MH). Read More

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Long anterior lens zonules with retinal stripes: a case report.

BMC Ophthalmol 2022 Jun 23;22(1):274. Epub 2022 Jun 23.

Hebei Ophthalmology Key Lab, Hebei Eye Hospital, No. 399, Quanbei East Street, Xingtai, 054000, Hebei, China.

Background: Long anterior lens zonules   (LAZs) is a rare disease that was mostly conducted among African Americans. Through the observation of a Chinese patient, we discoverd that the disease may show different characteristics in Asians.

Case Presentation: A patient with vision loss due to a macular hole was found to have several special clinical signs during vitrectomy combined with phacoemulsification and intraocular lens implantation surgery in our hospital, including radially oriented lines on the anterior capsule with pigment, a shallow anterior chamber, slightly high intraocular pressure, and radial retinal stripes in the peripheral retina. Read More

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Vertical Internal Limiting Membrane Stalk after Macular Hole Surgery.

Ophthalmology 2022 Jul;129(7):751

Department of Ophthalmology, Chair of Ophthalmology and Optometry, Poznan University of Medical Sciences, Poznan, Poland.

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Inverted multi-layer internal limiting membrane flap for macular hole retinal detachment in high myopia.

Sci Rep 2022 Jun 22;12(1):10593. Epub 2022 Jun 22.

Hunan Key Laboratory of Ophthalmology, Eye Center of Xiangya Hospital, Central South University, Changsha, China.

To investigate the surgical outcomes of pars plana vitrectomy (PPV) combined with inverted multi-layer internal limiting membrane (ILM) flap for the treatment of macular hole retinal detachment in high myopia. We retrospectively analysed the medical records of macular hole retinal detachment (MHRD) patients with high myopia. The patients were divided into two groups with different surgical procedure: inverted multi-layer ILM flap group (group 1, 27 eyes) and the ILM peeling group (group 2, 29 eyes). Read More

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Clinical features of ocular sarcoidosis: severe, refractory, and prolonged inflammation.

Jpn J Ophthalmol 2022 Jun 21. Epub 2022 Jun 21.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

Purpose: To clarify the proportion of ocular sarcoidosis with severe, refractory, and prolonged inflammation and their association with ocular complications and visual prognosis.

Study Design: Multicenter, retrospective, longitudinal cohort study.

Methods: Three hundred and twenty-three eyes of 164 patients (45 men; 119 women) with ocular sarcoidosis who visited Hokkaido University Hospital and Yokohama City University Hospital from 2010 to 2015. Read More

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Influence of Race, Ethnicity, and Socioeconomic Factors in Idiopathic Macular Hole Presentation and Surgical Outcomes.

Ophthalmic Surg Lasers Imaging Retina 2022 06 1;53(6):333-344. Epub 2022 Jun 1.

Background And Objective: To characterize the influence of race, ethnicity, and socioeconomic factors on idiopathic macular hole (IMH) presentation and surgical outcomes.

Patients And Methods: This retrospective cohort study of patients diagnosed with IMH who underwent surgical repair collected IMH data from optical coherence tomography scans as well as demographic information. Univariate and multivariate regression models interrogated relevant relationships. Read More

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Retina 2022 07;42(7):1277-1283

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.

Purpose: To compare pneumatic vitreolysis and pars plana vitrectomy in the management of focal symptomatic vitreomacular traction (VMT).

Method: Patients aged 18 years or older, with idiopathic focal symptomatic VMT and best-corrected visual acuity <20/40, without any other retinal pathology were randomized to undergo pneumatic vitreolysis (Group 1) or pars plana vitrectomy (Group 2). The primary outcome measure was resolution of traction confirmed with optical coherence tomography at 3 months. Read More

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Retina 2022 07;42(7):1262-1267

Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Purpose: To compare surgical outcomes of filtered air and sulfur hexafluoride (SF6) as an internal tamponade in patients undergoing primary 25-gauge pars plana vitrectomy for uncomplicated rhegmatogenous retinal detachment with inferior breaks.

Methods: Patients with uncomplicated rhegmatogenous retinal detachment associated with inferior breaks (between 4 and 8 o'clock positions) who were undergoing primary pars plana vitrectomy were enrolled. All eyes underwent pars plana vitrectomy and complete drainage of subretinal fluid, followed by filtered air or 20% SF6 tamponade. Read More

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Intentional use of topical latanoprost with resulting macular edema to help in the closure of a failed, chronic, macular hole.

Am J Ophthalmol Case Rep 2022 Sep 8;27:101603. Epub 2022 Jun 8.

Florida State University College of Medicine, 1115 West Call St, Tallahassee, FL, 32306, USA.

Purpose: To report a case where the induction of macular edema with topical latanoprost coupled with in-office gas injection effectively sealed a persistent, chronic, macular hole.

Observations: A 70-year-old, pseudophakic, patient presented with a stage three, chronic, macular hole (MH) and vision reduced to 20/200. The symptoms had been present for 18 months. Read More

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September 2022

AAV2-hCHM Subretinal Delivery to the Macula in Choroideremia: Two Year Interim Results of an Ongoing Phase I/II Gene Therapy Trial.

Ophthalmology 2022 Jun 14. Epub 2022 Jun 14.

Scheie Eye Institute at the Perelman Center for Advanced Medicine; The Center for Advanced Retinal & Ocular Therapeutics; The Children's Hospital of Philadelphia, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, United States.

Purpose: To assess the safety of the subretinal delivery of a recombinant adeno-associated virus serotype 2 (AAV2) vector carrying a human CHM-encoding cDNA in choroideremia (CHM).

Design: Prospective, open-label, non-randomized, dose-escalation, phase 1/2 clinical trial.

Subjects, Participants, And/or Controls: Fifteen CHM patients (ages 20-57 years at dosing). Read More

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A Novel Subfoveal Perfluorocarbon Liquid Removal Technique Combining a 25-Gauge Retrobulbar Needle With a Built-in 30-Gauge Needle.

Front Med (Lausanne) 2022 31;9:894991. Epub 2022 May 31.

Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Introduction: To report a novel combining a 25-gauge retrobulbar needle with a built-in 30-gauge needle surgical technique for subfoveal perfluorocarbon liquid (PFCL) removal.

Materials And Methods: Fourteen eyes of 14 patients who underwent subfoveal PFCL removal with a 25-gauge retrobulbar needle combined with a built-in 30-gauge needle were studied. The 30-gauge needle was inserted into the 25-gauge retrobulbar needle. Read More

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Outcomes from the Retrospective Multicenter Cross-Sectional Study on Lamellar Macular Hole Surgery.

Clin Ophthalmol 2022 8;16:1847-1860. Epub 2022 Jun 8.

Department of Ophthalmology, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Purpose: To analyze the functional and anatomical parameters of lamellar macular hole (LMH) surgery with internal limiting membrane peeling and determine which surgical technique provides the best visual outcome.

Methods: This is a retrospective multicenter cross-sectional study on patients who underwent pars plana vitrectomy (PPV) for LMH with or without combined phaco-vitrectomy, as well as gas-, air- or BSS-tamponade. Pre- and postoperative examination included best corrected visual acuity (BCVA) measurements for functional comparison and optical coherence tomography (OCT) scans to determine the contributing anatomical parameters. Read More

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[Progress in the treatment of refractory macular hole by human amniotic membrane].

Q H Wang H Yan

Zhonghua Yan Ke Za Zhi 2022 Jun;58(6):467-471

Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China.

The surgery of refractory macular hole is often very tough for its uncertain prognosis. There is no unified definition for refractory macular hole, which usually refers to macular hole with a long duration, large diameter, or failure of initial operation. Treatment success can be achieved in some cases by expanding the range of internal limiting membrane peeling or filling with autologous tissue. Read More

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[Choroidal blood flow and visual function in idiopathic macular hole].

Zhonghua Yan Ke Za Zhi 2022 Jun;58(6):412-419

Eye Hospital of Wenzhou Medical University, National Clinical Research Center for Ocular Diseases, Wenzhou 325027, China.

To investigate the choroidal blood flow and visual function in idiopathic macular hole. In this prospective study, fundus structure and visual function in 22 eyes with macular hole and their fellow eyes and 16 normal eyes were assessed. The best corrected visual acuity and retinal sensitivity were detected by the EDTRS visual chart and MP1. Read More

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In vivo generated autologous plasmin assisted vitrectomy in young patients.

Int J Retina Vitreous 2022 Jun 11;8(1):36. Epub 2022 Jun 11.

Department of Ophthalmology, Istanbul Medipol Medical School, Istanbul, Turkey.

Background: Autologous plasmin enzyme facilitates the induction of posterior vitreous detachment(PVD) during vitrectomy in young patients. We proposed the concept of in-vivo generated plasmin which is based on the injection of tissue plasminogen activator(t-PA) and autologous whole blood(AWB) into the vitreous cavity. The purpose of this pilot study is to report the efficacy of preoperative simultaneous intravitreal injection of(t-PA) and autologous whole blood in facilitating the intraoperative induction of PVD in young patients with various vitreoretinal pathologies. Read More

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Effect of Diabetes Mellitus and Systemic Hypertension on Macular Hole Surgery.

J Coll Physicians Surg Pak 2022 Jun;32(6):758-762

Department of Ophthalmology, Health Sciences University Haydarpaşa Numune Training and Research Hospital, Uskudar, Istanbul, Turkey.

Objective: To evaluate the anatomical and functional results of macular hole surgery in patients with diabetes mellitus (DM) and hypertension (HT) without retinopathy.

Study Design: Descriptive comparative study.

Place And Duration Of Study: Department of Ophthalmology, Health Sciences University Haydarpaşa Numune Training and Research Hospital, Turkey between January 2016 and December 2020. Read More

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Secondary Full-thickness Macular Holes after Diabetic Vitrectomy: Clinical Manifestations and Rational Approaches to the Treatment.

J Ophthalmol 2022 31;2022:3156642. Epub 2022 May 31.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Purpose: The aim of the study is to present the clinical characteristics and surgical treatment of secondary full-thickness macular hole (MH) after diabetic vitrectomy (DV) in patients with proliferative diabetic retinopathy (PDR).

Methods: In this retrospective, observational, and longitudinal study, we enrolled consecutive patients with PDR who developed MH after DV. The macular structure was evaluated using optical coherence tomography. Read More

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Automatic Determination of the Center of Macular Hole Using Optical Coherence Tomography En Face Images.

J Clin Med 2022 Jun 2;11(11). Epub 2022 Jun 2.

Department of Ophthalmology, Saitama Medical University, Saitama 350-0495, Japan.

To evaluate the automated determination of the center of an idiopathic macular hole (MH) by using swept-source optical coherence tomography (OCT) images with new macro-based algorithms in ImageJ and to compare the difference between the MH center measurements obtained automatically and manually. This cross-sectional study included 39 eyes of 39 elderly individuals (22 women, 17 men) with stage 3 and 4 MH. The MH center was automatically determined using the ImageJ macro. Read More

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Postoperative retinal microstructure and functional outcome after inverted-flap technique associated with silicone oil tamponade in macular hole surgery.

Rom J Morphol Embryol 2021 Oct-Dec;62(4):991-1000

Department of Ophthalmology, Carol Davila University of Medicine and Pharmacy, Clinical Hospital for Ophthalmological Emergencies, Bucharest, Romania;

Purpose: Our retrospective study on 27 patients with a large mean macular hole diameter (MH-D) of 480.08±78.62 μm evaluates the usefulness of combining the current internal limiting membrane (ILM) inverted-flap surgical technique with silicone oil tamponade, which has been associated with the classical technique of ILM peeling. Read More

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Microvolume Analysis of Aflibercept in Aqueous Humor Using Mass Spectrometry.

Transl Vis Sci Technol 2022 Jun;11(6)

Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Purpose: To develop a microvolume analytical method for measurement of the aflibercept concentration in human intraocular fluid and plasma.

Methods: We analyzed trace amounts of aflibercept in human aqueous humor using Fab-selective proteolysis and nano-surface and molecular-orientation limited (nSMOL) proteolysis, coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Patients with age-related macular degeneration or diabetic macular edema were recruited. Read More

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Postoperative microstructural re-modelling and functional outcomes in idiopathic full thickness macular hole.

Indian J Ophthalmol 2022 Jun;70(6):2077-2083

Department of Ophthalmology, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli, Maharashtra, India.

Purpose: To analyze the effect of various macular hole indices and postoperative microstructural changes of all retinal layers on postoperative functional outcomes in patients with idiopathic full-thickness macular hole (FTMH).

Methods: In this prospective study, pre and post-operative optical coherence tomography (OCT) scans of 36 eyes with idiopathic FTMH were analyzed. Hole indices and microstructural changes of all retinal layers such as ellipsoid zone (EZ), external limiting membrane (ELM) integrity, outer and inner retinal defects, and cystoid resolution were studied on follow-up visits. Read More

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Proteomic Insight into the Role of Exosomes in Proliferative Vitreoretinopathy Development.

J Clin Med 2022 May 11;11(10). Epub 2022 May 11.

Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

: To characterize vitreous humor (VH) exosomes and to explore their role in the development of proliferative vitreoretinopathy (PVR) using mass spectrometry-based proteome profiling. : Exosomes were isolated from undiluted VH from patients with retinal detachment (RD) with various stages of PVR ( = 9), macular hole (MH; = 5), or epiretinal membrane (ERM; = 5) using differential ultracentrifugation. The exosomal size, morphology, and exosome markers were analyzed using a nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM), and an exosome detection antibody array. Read More

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Intraretinal Layer Segmentation Using Cascaded Compressed U-Nets.

J Imaging 2022 May 17;8(5). Epub 2022 May 17.

Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13125 Berlin, Germany.

Reliable biomarkers quantifying neurodegeneration and neuroinflammation in central nervous system disorders such as Multiple Sclerosis, Alzheimer's dementia or Parkinson's disease are an unmet clinical need. Intraretinal layer thicknesses on macular optical coherence tomography (OCT) images are promising noninvasive biomarkers querying neuroretinal structures with near cellular resolution. However, changes are typically subtle, while tissue gradients can be weak, making intraretinal segmentation a challenging task. Read More

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Factors Affecting Visual Prognosis of Myopic Foveoschisis after Macular Buckling.

J Ophthalmol 2022 17;2022:9293347. Epub 2022 May 17.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.

Purpose: To analyze the visual prognosis of macular buckling in patients with high myopia foveoschisis (FS) and to identify factors that predict the final visual outcome.

Methods: We retrospectively included 155 eyes of 155 patients who underwent foveoschisis-related macular buckling. Best-corrected visual acuity (BCVA) and coexisting macular pathologies were assessed as a measure of surgical outcome, and multivariate linear regression was performed to identify factors affecting final visual prognosis. Read More

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The Clinical and Safety Outcomes of 27 Gauge Pars Plana Vitrectomy in Eyes With Macular Hole.

Cureus 2022 Apr 23;14(4):e24409. Epub 2022 Apr 23.

Ophthalmology, Shifa International Hospital, Islamabad, PAK.

Objective To report the clinical, visual, and safety outcomes of 27 gauge pars plana vitrectomy (27G PPV) in eyes with full thickness and lamellar macular hole (MH).  Methodology This retrospective cross-sectional study, conducted at the ophthalmology department of Shifa International Hospital, Islamabad, was done on 89 eyes of 85 patients who underwent 27G PPV for full-thickness and lamellar MH with a postoperative follow-up period of six months.  Results The mean age was 61. Read More

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A Deep Learning Method for Automatic Identification of Drusen and Macular Hole from Optical Coherence Tomography.

Stud Health Technol Inform 2022 May;294:565-566

Department of Engineering and Architecture, University of Trieste, Trieste, Italy.

Deep Learning methods have become dominant in various fields of medical imaging, including ophthalmology. In this preliminary study, we investigated a method based on Convolutional Neural Network for the identification of drusen and macular hole from Optical Coherence Tomography scans with the aim to assist ophthalmologists in diagnosing and assessing retinal diseases. Read More

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Macular Hole Formation Following Intravitreal Aflibercept for Neovascular Age-Related Macular Degeneration.

Case Rep Ophthalmol 2022 Jan-Apr;13(1):247-252. Epub 2022 Apr 4.

Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.

This case report describes full-thickness macular hole formation after intravitreal aflibercept injections for the treatment of macular neovascularization in neovascular age-related macular degeneration (AMD). Only limited case reports and case series have reported this possible adverse event after aflibercept injection. Possible mechanisms leading to the formation of a macular hole subsequent to intravitreal injection are focal tractional forces on the vitreoretinal interface due to globe deformation during needle insertion, vitreous syneresis, and vitreous incarceration at the injection site, and tangential shearing forces on the posterior surface of the retina due to contraction and rapid volume reduction of the neovascular membrane or a decrease in intra- or subretinal fluid. Read More

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Amniotic membrane for covering high myopic macular hole associated with retinal detachment following failed primary surgery.

Int J Ophthalmol 2022 18;15(5):760-765. Epub 2022 May 18.

Wanjiang Eye Hospital of Mianyang, Mianyang 621000, Sichuan Province, China.

Aim: To evaluate the therapeutic effect of amniotic membrane (AM) for covering high myopic macular hole associated with retinal detachment following failed primary surgery.

Methods: Seventeen eyes of 17 patients whose axial length was more than 29 mm suffered from macular hole (MH) or MH associated with retinal detachment (RD), and had previously surgery of pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling and silicone oil (SO) tamponade. Half a year after the surgery, optical coherence tomography (OCT) showed that MH did not heal in all 17 eyes and RD was still maintained in 13 eyes of these 17 eyes. Read More

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Angiogenesis and Anastomosis on Graft Retina after Autologous Retinal Transplantation.

Ophthalmol Retina 2022 May 18. Epub 2022 May 18.

Department of Ophthalmology and Micro-technology, Yokohama City University, Yokohama, Japan. Electronic address:

Anastomosis on graft retina was studied after autologous retinal transplantation (ART) on 26 eyes with primary and refractory macular holes. Angiogenesis and anastomosis were seen in 35% of the eyes with successful ART, likely contributing to the survival of the transplanted retina. Read More

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