5,987 results match your criteria Macular Hole


Characteristics and Risk Factors for Spontaneous Closure of Idiopathic Full-Thickness Macular Hole.

Authors:
Xida Liang Wu Liu

J Ophthalmol 2019 13;2019:4793764. Epub 2019 Mar 13.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing 100730, China.

Idiopathic full-thickness macular hole is a severe visual impairment disease. Pars plana vitrectomy remains the primary treatment option for idiopathic full-thickness macular holes, and over 90% idiopathic full-thickness macular holes are closed by vitrectomy surgery. However, the full-thickness macular hole may close spontaneously, with a good visual acuity progress. Read More

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http://dx.doi.org/10.1155/2019/4793764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436358PMC

Long-term natural history of idiopathic epiretinal membranes with good visual acuity.

Eye (Lond) 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology & Vision Sciences, University of California, Davis, Sacramento, CA, USA.

Background/objectives: To evaluate the long-term progression of idiopathic epiretinal membranes (iERMs) with good baseline visual acuity, and to identify predictors of visual decline.

Design: Retrospective case series SUBJECTS METHODS: We reviewed records of 145 eyes with iERM and best-corrected visual acuity (BCVA) of 20/40 or greater at presentation, including BCVA, lens status, and central macular thickness (CMT) at yearly visits; as well as anatomic biomarkers including vitreomacular adhesion, pseudohole, lamellar hole, intraretinal cysts, disorganization of the inner retinal layers (DRIL), and disruption of outer retinal layers. Linear mixed effects and mixed-effects Cox proportional hazards models were used to identify clinical and anatomic predictors of vision change and time to surgery. Read More

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http://www.nature.com/articles/s41433-019-0397-z
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http://dx.doi.org/10.1038/s41433-019-0397-zDOI Listing
April 2019
1 Read

Intraoperative Optical Coherence Tomography Demonstrating Macular Hole Associated With Ruptured Retinal Arterial Macroaneurysm.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e125-e127

A 67-year-old female presented with vitreous hemorrhage and sub-internal limited membrane (ILM) hemorrhage in her right eye associated with ruptured retinal arterial macroaneurysm. During pars plana vitrectomy, intraoperative optical coherence tomography aided in the diagnosis of a small macular hole previously obscured by the sub-ILM hemorrhage. Nonexpansile gas was placed followed by postoperative prone positioning, and the hole closed successfully. Read More

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http://dx.doi.org/10.3928/23258160-20190401-17DOI Listing

Higher Vascular Density of the Superficial Retinal Capillary Plexus in Degenerative Lamellar Macular Holes.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e112-e117

Background And Objective: Optical coherence tomography angiography (OCTA) comparison between vessel density in patients with degenerative-subtype lamellar macular hole (LMH) and healthy individuals. Unaffected fellow eyes were also included in the study.

Patients And Methods: This observational, cross-sectional study examined 32 eyes affected by unilateral degenerative-subtype LMH, as well as the 32 fellow eyes of the enrolled population. Read More

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http://dx.doi.org/10.3928/23258160-20190401-15DOI Listing
April 2019
1 Read

Sulfur Hexafluoride (SF) versus Perfluoropropane (CF) in the Intraoperative Management of Macular Holes: A Systematic Review and Meta-Analysis.

J Ophthalmol 2019 12;2019:1820850. Epub 2019 Mar 12.

Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel.

Purpose: A systematic literature search was conducted to identify and review studies comparing SF to CF as a tamponade agent in the intraoperative management of macular holes.

Methods: Publications up to October 2018 that focused on macular hole surgery in terms of primary closure, complications, and clinical outcomes were included. Forest plots were created using a weighted summary of proportion meta-analysis. Read More

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http://dx.doi.org/10.1155/2019/1820850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434271PMC

Patient-reported outcomes of ocriplasmin for the treatment of vitreomacular traction: a systematic review and synthesis of the literature.

Patient Relat Outcome Meas 2019 27;10:101-116. Epub 2019 Mar 27.

Life Sciences and Medicine, King's College London, Department of Ophthalmology, King's College Hospital, London, UK.

Purpose: Vitreomacular traction (VMT) is a disease in which the vitreous exerts abnormally strong traction on the macula, the area of the eye responsible for detailed central vision. If this traction significantly distorts the macula then VMT can lead to troublesome distorted vision (metamorphopsia), sometimes occurring despite relatively preserved visual acuity. Ocriplasmin, administered as a single intravitreal injection, aims to release VMT and improve vision. Read More

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http://dx.doi.org/10.2147/PROM.S153718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443223PMC

Macular Hole in Myopic Eyes: A Narrative Review of the Current Surgical Techniques.

J Ophthalmol 2019 11;2019:3230695. Epub 2019 Mar 11.

Eye Clinic, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Macular hole (MH) in myopic eyes is a disease arising from complex tractional forces exerted by vitreomacular interface, epiretinal tissue, and progressive scleral ectasia of the posterior ocular globe wall. This retinal disease requires vitreoretinal treatment for its repair, and the surgical intervention remains a challenge also for experienced surgeons. The aim of this review is to describe the current knowledge regarding the pathogenesis of MH in myopic eyes and to detail novel surgical techniques and technological advancements in its surgical management. Read More

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https://www.hindawi.com/journals/joph/2019/3230695/
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http://dx.doi.org/10.1155/2019/3230695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432738PMC
March 2019
1 Read

Macular Hole Formation after Intravitreal Injection of Bevacizumab for Diabetic Macular Edema.

Korean J Ophthalmol 2019 Apr;33(2):198-199

Department of Ophthalmology, Kangwon National University School of Medicine, Chuncheon, Korea.

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https://synapse.koreamed.org/DOIx.php?id=10.3341/kjo.2018.00
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http://dx.doi.org/10.3341/kjo.2018.0079DOI Listing
April 2019
1 Read

Epiretinal Proliferation Associated with Lamellar Hole or Macular Hole: Origin and Surgical Prognosis.

Korean J Ophthalmol 2019 Apr;33(2):142-149

Department of Ophthalmology, HanGil Eye Hospital, Incheon, Korea.

Purpose: To determine the origin of epiretinal proliferation (EP), a condition that is occasionally observed in lamellar hole and macular hole cases, and EP outcomes after vitrectomy.

Methods: This is a retrospective observational case review of 17 eyes with EP that underwent vitrectomy, EP dissection, and internal limiting membrane peeling between January 2013 and December 2016. Surgical specimens of EP tissue were successfully obtained from 5 cases and they were analyzed after immunohistochemical staining. Read More

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http://dx.doi.org/10.3341/kjo.2018.0070DOI Listing

Optimizing optical coherence tomography and histopathology correlation in retinal imaging.

Can J Ophthalmol 2019 Apr 27;54(2):280-287. Epub 2018 Aug 27.

Pathology Department, McGill University, Montreal, Que., Canada; Ophthalmology Department, Federal University of São Paulo, São Paulo, Brazil.

Objective: To develop a methodology to correlate optical coherence tomography (OCT) images and histopathological sections from the same eye. Part 1: To determine the best fixative for optimal OCT and histopathological analysis in post-mortem eyes. Part 2: A protocol is proposed to correlate histopathological features and OCT scans from the same post-mortem eyes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00084182183057
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http://dx.doi.org/10.1016/j.jcjo.2018.06.024DOI Listing
April 2019
2 Reads
1.299 Impact Factor

Asymmetry of the macular structure is associated with ocular dominance.

Can J Ophthalmol 2019 Apr 19;54(2):237-241. Epub 2018 Jun 19.

Department of Ophthalmology and Visual Science, St. Vincent's Hospital, College of Medicine, Catholic University of Korea, Seoul, South Korea. Electronic address:

Objective: We hypothesized that the ocular dominance associated with brain asymmetry would influence macular structure. We assessed the structural asymmetry of the macula by ocular dominance.

Methods: A total of 144 patients with no ophthalmic abnormalities were examined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00084182173113
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http://dx.doi.org/10.1016/j.jcjo.2018.04.020DOI Listing
April 2019
2 Reads

Intravitreal neurodegenerative and inflammatory mediators in proliferative diabetic retinopathy.

Arq Bras Oftalmol 2019 Apr 8. Epub 2019 Apr 8.

Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Purpose: To compare the intravitreal concentrations of cellular mediators involved in neurodegeneration, inflammation, and angiogenesis in patients with proliferative diabetic retinopathy and other vitreoretinal diseases.

Methods: A multiplex bead immunoassay was used to measure vitreous levels of pigment epithelium-derived factor, serum amyloid P, C-reactive protein, complement C4, alpha-1 antitrypsin, vascular endothelial growth factor, platelet-derived growth factor-AA, platelet-derived growth factor-BB, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor alpha and beta in patients undergoing 23-gauge vitrectomy for proliferative diabetic retinopathy and other diagnoses (control group).

Results: We evaluated 55 patients, of whom 24 had proliferative diabetic retinopathy and 31 had other diagnoses including vitreous hemorrhage, retinal detachment, macular hole, and epiretinal membrane. Read More

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http://dx.doi.org/10.5935/0004-2749.20190055DOI Listing
April 2019
1 Read

Anterior chamber aqueous flare is not a predictor for surgical closure of full-thickness idiopathic macular holes.

Eur J Ophthalmol 2019 Apr 10:1120672119843283. Epub 2019 Apr 10.

1 Department of Ophthalmology, University of Cologne, Cologne, Germany.

Purpose: To investigate the predictive value of preoperative anterior chamber aqueous flare levels measured by laser flare photometry for surgical success of idiopathic macular holes in addition to preoperative anatomic characteristics.

Methods: Records of 105 consecutive eyes with full-thickness idiopathic macular holes which underwent pars plana vitrectomy with internal limiting membrane peeling and sulfur hexafluoride 20% (SF20%) endotamponade were reviewed retrospectively. All patients underwent preoperative measurements of anterior chamber aqueous flare and anatomical idiopathic macular hole characteristics evaluated by optical coherence tomography: macular hole inner opening diameter, macular hole minimum linear diameter, macular hole base diameter, and macular hole height. Read More

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http://dx.doi.org/10.1177/1120672119843283DOI Listing

Prevalence and Associations of Posterior Segment Manifestations in a Cohort of Egyptian Patients with Pathological Myopia.

Curr Eye Res 2019 Apr 9. Epub 2019 Apr 9.

a Department of Ophthalmology, Faculty of Medicine , Cairo University , Cairo , Egypt.

Purpose: To determine the prevalence of posterior segment manifestations among consecutive patients with pathological myopia attending our University Hospital general ophthalmology clinic and their association with age, refractive error, axial length and each other.

Methods: Patients diagnosed with pathological myopia underwent full ophthalmological examination, optical coherence tomography, fluorescein angiography, and ocular ultrasonography. Manifestations detected were recorded for each eye and their prevalence and association with age, refractive error, axial length and each other was determined. Read More

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http://dx.doi.org/10.1080/02713683.2019.1606252DOI Listing
April 2019
2 Reads

An Internal Limiting Membrane Plug and Gas Endotamponade for Recurrent or Persistent Macular Hole.

J Ophthalmol 2019 7;2019:6051724. Epub 2019 Mar 7.

Dipartimento Neuro-muscoloscheletrico e Organi di Senso, Azienda Ospedaliera Universitaria di Careggi, Florence, Italy.

Introduction: Recurrent or persistent macular holes (MHs) are rare today due to the tendency to carefully peel the internal limiting membrane. Conversely, their treatment is still a challenge for a vitreoretinal surgeon.

Materials And Methods: This is a retrospective, consecutive, and nonrandomized study of patients affected by recurrent or persistent MHs treated using small-gauge pars plana vitrectomy (25- or 23-gauge) and an autologous ILM plug, at the Eye Clinic of Azienda Ospedaliera Universitaria Careggi (Florence, Italy) between January 2016 and May 2018. Read More

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http://dx.doi.org/10.1155/2019/6051724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431435PMC
March 2019
1 Read

Long-term outcomes of patients with myopic traction maculopathy after phacoemulsification for incident cataract.

Eye (Lond) 2019 Apr 5. Epub 2019 Apr 5.

Department of Ophthalmology, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, 200031, Shanghai, China.

Purpose: To evaluate the long-term effect of cataract surgery on highly myopic patients with myopic traction maculopathy (MTM) and the risk factors associated with MTM progression.

Methods: Highly myopic patients with cataract and MTM were included. Phacoemulsification surgery was performed on patients who had vision loss below 20/63 and were willing to operation. Read More

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http://dx.doi.org/10.1038/s41433-019-0416-0DOI Listing
April 2019
3 Reads

Premacular Cell Proliferation Profiles in Tangential Traction Vitreo-Maculopathies Suggest a Key Role for Hyalocytes.

Ophthalmologica 2019 Apr 4:1-7. Epub 2019 Apr 4.

Department of Ophthalmology, Ludwig Maximilian University, Munich, Germany,

Purpose: To compare immunocytochemical and ultrastructural features of premacular tissue surgically removed from eyes with tangential traction vitreo-maculopathies.

Methods: By spectral-domain optical coherence tomography (SD-OCT), premacular tissue was differentiated into premacular proliferation and premacular membrane (PMM). Specimens were harvested during vitrectomy from 10 eyes with macular pucker, lamellar macular hole (LMH) and full-thickness macular hole, and prepared for immunocytochemistry and transmission electron microscopy. Read More

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http://dx.doi.org/10.1159/000495853DOI Listing
April 2019
2 Reads

Biomarkers for PVR in rhegmatogenous retinal detachment.

PLoS One 2019 3;14(4):e0214674. Epub 2019 Apr 3.

Swiss Eye Institute and Clinic for Vitreoretinal Diseases, Berner Augenklinik am Lindenhof-Spital, Bern, Switzerland.

Purpose: Various profibrotic and proinflammatory cytokines have been found upregulated in uncomplicated primary retinal detachment (pRD), but without providing a uniform picture. Here, we compare the cyto- and chemokine profiles in pRD with and without proliferative vitreoretinopathy (PVR) in an attempt to unravel relevant differences not in single cytokines, but in the cytokine profiles at diagnosis.

Methods: Undiluted vitreous fluid (VF) was obtained at the beginning of surgery from 174 eyes with pRD without relevant PVR (maximally grade B; group 1; n = 81) and with moderate or advanced PVR requiring a gas tamponade (group 2; n = 49) or silicon oil filling (group 3; n = 44). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214674PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447182PMC
April 2019
3 Reads

Ocriplasmin Treatment Leads to Symptomatic Vitreomacular Adhesion/Vitreomacular Traction Resolution in the Real-World Setting: The Phase IV ORBIT Study.

Ophthalmol Retina 2019 Jan 25;3(1):32-41. Epub 2018 Jul 25.

California Retina Consultants, Santa Barbara, California; California Retina Research Foundation, Santa Barbara, California.

Purpose: To evaluate clinical outcomes and safety up to 12 months after ocriplasmin injection for the treatment of patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction (VMT) in a real-world setting.

Design: The Phase IV Ocriplasmin Research to Better Inform Treatment (ORBIT) trial (NCT02079883) was a Phase IV multicenter, prospective, observational study.

Participants: Patients aged ≥18 years with symptomatic VMA/VMT treated with ocriplasmin. Read More

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http://dx.doi.org/10.1016/j.oret.2018.07.011DOI Listing
January 2019
2 Reads

SPONTANEOUS CLOSURE OF A MACULAR HOLE RESULTING FROM YAG LASER CAPSULOTOMY IN A 13-YEAR-OLD GIRL.

Retin Cases Brief Rep 2019 Mar 28. Epub 2019 Mar 28.

Dell Medical School, University of Texas Austin, Austin, Texas.

Purpose: To describe the novel finding of spontaneous resolution of a full-thickness macular hole resulting from YAG laser capsulotomy in a 13-year-old girl with previous history of retinal detachment repair and cataract surgery.

Methods: A 13-year-old girl who had developed a macular hole after YAG laser was noted to have spontaneous resolution of the macular hole at 2-week follow-up visit with concurrent increase in visual acuity. Institutional review board was not applicable for this case. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000871DOI Listing
March 2019
2 Reads

Ocular findings in posterior microphthalmos.

Saudi J Ophthalmol 2019 Jan-Mar;33(1):41-45. Epub 2018 Oct 21.

Ophthalmology Department, Haseki Training and Research Hospital, İstanbul, Turkey.

Aim: To report a critical case series of six patients with posterior microphthalmos (PM).

Method: Complete ophthalmologic examinations of all patients were performed using best-corrected visual acuity (BCVA), cycloplegic refraction, applanation tonometry, slit lamp biomicroscopy of the anterior segment, fundoscopy, A and B mode ultrasonography (USG), keratometry, and optic coherence tomography (OCT).

Results: The most significant clinical characteristics of male patients aged 10-25 years was the presence of shorter posterior segments (mean: 15. Read More

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http://dx.doi.org/10.1016/j.sjopt.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424690PMC
October 2018
1 Read

Subfoveal Lucency after Treatment of Vitreomacular Traction without Macular Hole in the Phase 3 Trials of Ocriplasmin Vitreolysis.

Ophthalmol Retina 2019 Jan 28;3(1):42-52. Epub 2018 Jun 28.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina. Electronic address:

Purpose: To describe the clinical impact of subfoveal lucency (SFL) seen on OCT before and after treatment of vitreomacular traction (VMT) or symptomatic vitreomacular adhesion (VMA) without macular hole (MH) in the prospective phase 3 trials of ocriplasmin vitreolysis.

Design: Randomized double-blind placebo-controlled multicenter study.

Participants: Four hundred ninety-nine eyes with VMT or VMA without MH. Read More

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http://dx.doi.org/10.1016/j.oret.2018.05.004DOI Listing
January 2019
1 Read

Characteristics of central visual field defect after macular hole surgery.

Int J Ophthalmol 2019 18;12(3):451-456. Epub 2019 Mar 18.

Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China.

Aim: To investigate the characteristics of postoperative central visual field defect (cVFD) in patients with macular hole (MH).

Methods: Eighteen eyes from 18 MH patients were involved in this retrospective study which reviewed square root of loss variance (sLV) and mean defect (MD) of the visual field test in all subjects. The relationship between cVFD and MH stage, as well as the postoperative ellipsoid zone disruption were evaluated using Spearman's correlation test. Read More

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http://dx.doi.org/10.18240/ijo.2019.03.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423390PMC

Perspectives of Autologous Mesenchymal Stem-Cell Transplantation in Macular Hole Surgery: A Review of Current Findings.

J Ophthalmol 2019 24;2019:3162478. Epub 2019 Feb 24.

S.C.U. Ophthalmology Unit, "City of Health and Science" University Hospital, Via Cherasco 23, 10126 Turin, Italy.

The main treatment available for idiopathic macular holes is represented by pars plana vitrectomy with internal limiting membrane peeling. However, late-stage macular holes are affected by a higher risk of surgical failure. Although adjuvant techniques can be employed, a satisfactory functional recovery is difficult to achieve in refractory macular holes. Read More

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http://dx.doi.org/10.1155/2019/3162478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409040PMC
February 2019

MULTIPLE LATE RECURRENCES OF MACULAR HOLE AFTER VITRECTOMY AND EPISODE OF SPONTANEOUS CLOSURE IN A SINGLE EYE.

Retin Cases Brief Rep 2019 Mar 25. Epub 2019 Mar 25.

Dell Medical School, University of Texas at Austin, Austin, Texas.

Purpose: To report the novel finding of multiple recurrences of full-thickness macular hole in a 70-year-old woman with one episode of spontaneous closure.

Methods: Case report of a 70-year-old woman who initially presented with a full-thickness macular hole who developed 3 subsequent recurrences of full-thickness macular hole over a duration of 4 years. Spontaneous closure was noted at the second recurrence. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000870DOI Listing

POSTERIORLY INSERTED VITREOUS BASE: Preoperative Characteristics, Intraoperative Findings, and Outcomes After Vitrectomy.

Retina 2019 Feb 15. Epub 2019 Feb 15.

Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.

Purpose: To determine the preoperative characteristics, intraoperative and postoperative complications, and outcomes of eyes with posteriorly inserted vitreous base.

Methods: In this retrospective, observational, consecutive case series at 2 academic centers, 37 patients were studied who had posteriorly inserted vitreous base noted during vitrectomy. Posteriorly inserted vitreous base was defined as the insertion of the posterior hyaloid membrane being located posterior to the vortex veins. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002482DOI Listing
February 2019
1 Read

Optical coherence tomography angiography features in patients with idiopathic full-thickness macular hole, before and after surgical treatment.

Clin Interv Aging 2019 8;14:505-514. Epub 2019 Mar 8.

University Clinical Center, University Hospital Medical University of Silesia, Katowice, Poland,

Purpose: To present optical coherence tomography (OCT) angiography features in patients with idiopathic full-thickness macular hole before and after vitrectomy.

Study Design: Prospective case series study.

Materials And Methods: Patients presenting with an idiopathic full-thickness macular hole (IMH) who underwent posterior vitrectomy with internal limiting membrane peeling and gas tamponade were included in the study. Read More

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http://dx.doi.org/10.2147/CIA.S189417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413747PMC

Central perpendicular line in macular spectral-domain optical coherence tomography in five eyes.

Eur J Ophthalmol 2019 Mar 14:1120672119834476. Epub 2019 Mar 14.

Department of Ophthalmology, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium.

Purpose:: The aim of this study is to report a rare spectral-domain optical coherence tomography finding in the macula.

Methods:: This is a descriptive consecutive case series. Patients diagnosed with hyperreflective central perpendicular line in the macular spectral-domain optical coherence tomography were included. Read More

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http://dx.doi.org/10.1177/1120672119834476DOI Listing

RELAXING NASAL RETINOTOMY TECHNIQUE FOR CLOSURE OF A MACULAR HOLE THAT REOPENED AFTER PRIMARY VITRECTOMY.

Retin Cases Brief Rep 2019 Mar 6. Epub 2019 Mar 6.

Retina Consultants of Orange County, Fullerton, California.

Purpose: To describe relaxing nasal retinotomy as a technique to achieve closure of a recurrent macular hole.

Methods: A patient with juxtafoveal telangiectasia presented with recurrent macular hole after primary vitrectomy and internal limiting membrane peel. During repeat surgery, a superonasal retinotomy was performed to allow for release of tangential traction contributing to the macular hole. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000862DOI Listing

Macular buckle without vitrectomy for myopic macular schisis: a Canadian case series.

Can J Ophthalmol 2019 Feb 3;54(1):60-64. Epub 2018 May 3.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta.

Objective: To determine the effectiveness of a macular buckle procedure without vitrectomy for the treatment of symptomatic myopic macular schisis.

Design: Retrospective case series.

Participants And Methods: All patients who underwent surgery with placement of an NPB macular buckle (AJL Ophthalmic, Miñano, Álava, Spain) without vitrectomy for symptomatic myopic macular schisis were included. Read More

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http://dx.doi.org/10.1016/j.jcjo.2018.02.014DOI Listing
February 2019

Pars plana vitrectomy versus scleral buckling for repairing simple rhegmatogenous retinal detachments.

Cochrane Database Syst Rev 2019 03 8;3:CD009562. Epub 2019 Mar 8.

Department of Ophthalmology, University Hospital Centre Split, Spinciceva 1, Split, Croatia, 21000.

Background: Rhegmatogenous retinal detachment (RRD) is a separation of neurosensory retina from the underlying retinal pigment epithelium. It is caused by retinal tears, which let fluid pass from the vitreous cavity to the subretinal space. Pars plana vitrectomy (PPV), scleral buckling surgery and pneumatic retinopexy are three accepted management strategies whose efficacy remains controversial. Read More

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http://dx.doi.org/10.1002/14651858.CD009562.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407688PMC
March 2019
2 Reads

Clinical observation of treatment of idiopathic macular hole with internal limiting membrane transplantation combined with temporal flap turnover and air filling.

Panminerva Med 2019 Mar 4. Epub 2019 Mar 4.

Department of Ophtalmology, The First People's Hospital of Lianyungang, Lianyungang, China -

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http://dx.doi.org/10.23736/S0031-0808.19.03611-5DOI Listing
March 2019
4 Reads

Comparison of effectiveness between complete internal limiting membrane peeling and internal limiting membrane peeling with preservation of the central fovea in combination with 25G vitrectomy for the treatment of high myopic foveoschisis.

Medicine (Baltimore) 2019 Mar;98(9):e14710

Vitrectomy combined with internal limiting membrane peeling (ILMP) treats high myopic foveoschisis with good results, but there is a risk of iatrogenic macular holes, which may be reduced by preserving the internal limiting membrane of the central fovea. This study compared complete ILMP with partial ILMP, both combined with 25G vitrectomy, for the treatment of high myopic foveoschisis.Thirty-three cases (33 eyes) of high myopic foveoschisis were retrospectively analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000014710DOI Listing
March 2019
2 Reads

Clinical outcomes with large macular holes using the tiled transplantation internal limiting membrane pedicle flap technique.

Int J Ophthalmol 2019 18;12(2):246-251. Epub 2019 Feb 18.

Department of Ophthalmology, Shaanxi Ophthalmic Medical Center, Xi'an Fourth Hospital, Affiliated Guangren Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.

Aim: To report the surgical technique and efficacy of the tiled transplantation internal limiting membrane (ILM) pedicle flap technique after vitrectomy for 33 patients with large macular hole (MH).

Methods: This study was a prospective noncontrolled interventional study. All patients were treated by vitrectomy, the tiled transplantation ILM pedicle flap and gas tamponade. Read More

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http://dx.doi.org/10.18240/ijo.2019.02.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376224PMC
February 2019

Internal Limiting Membrane Flap in the Management of Retinal Detachment due to Paracentral Retinal Breaks.

J Ophthalmol 2019 21;2019:4303056. Epub 2019 Jan 21.

Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan.

Purpose: To describe the technique and outcomes of using either inverted or free internal limiting membrane flap in the management of retinal detachment due to paracentral retinal breaks.

Methods: This retrospective observational case series includes nine patients who received surgery for retinal detachment due to paracentral retinal breaks developed either from primary rhegmatogenous origin, or secondary iatrogenic retinal breaks after prior membrane peeling, or during surgery for tractional retinal detachment. Either inverted or free internal limiting membrane flaps were inserted in the identified breaks, followed by air fluid exchange and gas tamponade. Read More

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http://dx.doi.org/10.1155/2019/4303056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360606PMC
January 2019
3 Reads

Involvement of premacular mast cells in the pathogenesis of macular diseases.

PLoS One 2019 22;14(2):e0211438. Epub 2019 Feb 22.

Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.

We previously reported on the elevated intravitreal activities of tryptase and chymase in association with idiopathic epiretinal membrane (ERM) and idiopathic macular hole (MH). In this present study, we investigated the potential intraocular production of these serine proteases, and measured and compared tryptase and chymase activities in the vitreous body and serum in ERM, MH, proliferative diabetic retinopathy (PDR), and rhegmatogenous retinal detachment (RRD) patients. In addition, nuclear staining with hematoxylin and eosin (H&E) and mast-cell staining with toluidine blue were performed on samples of the vitreous core and bursa premacularis (BPM) of MH. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211438PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386310PMC
February 2019
4 Reads

Re: Baumgarten et al.: Vitrectomy with and without encircling band for pseudophakic retinal detachment with inferior breaks: VIPER Study Report No. 3. Graefes Arch Clin Exp Ophthalmol. 2018 Nov;256(11):2069-2073. doi: 10.1007/s00417-018-4106-6. Epub 2018 Aug 23.

Graefes Arch Clin Exp Ophthalmol 2019 04 20;257(4):843. Epub 2019 Feb 20.

Department of Ophthalmology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1007/s00417-019-04268-4DOI Listing
April 2019
3 Reads

Preoperative prognostic factors for macular hole surgery: Which is better?

Oman J Ophthalmol 2019 Jan-Apr;12(1):20-24

Department of Ophthalmology, Istanbul Research and Education Hospital, Istanbul, Turkey.

Aim: This study aims to evaluate the prognostic factors of different optical coherence tomography (OCT) parameters as well as the tamponade used in surgery, on postoperative anatomical and functional success.

Methods: Twenty-nine eyes of 27 patients were included in this study. A three-port 23-gauge pars plana vitrectomy was performed on all eyes with peeling of the internal limiting membrane by visualization with brilliant blue dye by the same surgeon (E. Read More

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http://dx.doi.org/10.4103/ojo.OJO_247_2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380157PMC
February 2019
5 Reads

Treatment of macular hemorrhage in retinal arterial microaneurysm: anatomic site-oriented therapy.

Jpn J Ophthalmol 2019 Mar 19;63(2):186-196. Epub 2019 Feb 19.

Department of Ophthalmology, Nihon University Hospital, 1-6 Surugadai, Kanda, Chiyodaku, Tokyo, 101-8309, Japan.

Purpose: To investigate the usefulness of anatomic site-oriented therapy for macular hemorrhage secondary to retinal arterial macroaneurysm (RAM).

Study Design: Retrospective observational study, clinical case series METHODS: Twenty-seven consecutive patients (27 eyes) with macular hemorrhage secondary to RAM were classified according to the retinal layer(s) with hemorrhage identified by optical coherence tomography into 4 types and treated differentially. Vitrectomy was conducted for subinternal limiting membrane hemorrhage (SILMH), intravitreal gas injection for subretinal hemorrhage (SRH) or intraretinal hemorrhage (IRH), and vitrectomy and intravitreal air/gas exchange for multilevel hemorrhage (at least 2 among SILMH/SRH/IRH). Read More

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http://dx.doi.org/10.1007/s10384-019-00653-yDOI Listing
March 2019
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Macular Hole Complicating Familial Exudative Vitreoretinopathy Due to LRP5 Mutation in an Adolescent.

Ophthalmic Surg Lasers Imaging Retina 2019 02;50(2):e49-e51

A 17-year-old boy, previously diagnosed with familial exudative vitreoretinopathy (FEVR) due to LRP5 mutation, complained of left eye decreased vision. Serial imaging by optical coherence tomography showed vitreomacular traction that progressed to lamellar macular hole (MH), and further evolved to full-thickness MH 3 weeks later. Visual acuity (VA) was 20/200. Read More

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http://dx.doi.org/10.3928/23258160-20190129-19DOI Listing
February 2019

Topical Aqueous Suppression and Closure of Idiopathic Full-Thickness Macular Holes.

Ophthalmic Surg Lasers Imaging Retina 2019 02;50(2):e38-e43

Hydration of retinal tissue has been proposed as a potential model of macular hole (MH) formation in addition to tractional forces of the vitreous and internal limiting membrane (ILM). Carbonic anhydrase inhibitors have previously been utilized in the treatment of cystoid macular edema in outer retinal diseases. There has been recent interest in the use of topical aqueous suppression as a potential medical therapy for MHs. Read More

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http://dx.doi.org/10.3928/23258160-20190129-17DOI Listing
February 2019

Current Management of Macular Hole.

Ophthalmic Surg Lasers Imaging Retina 2019 02;50(2):61-68

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http://dx.doi.org/10.3928/23258160-20190129-01DOI Listing
February 2019

Delayed spontaneous closure of blue laser-induced full thickness macular hole.

Am J Ophthalmol Case Rep 2019 Mar 9;13:154-156. Epub 2019 Jan 9.

Lebanese American University, Beirut, Lebanon.

Purpose: To report a blue laser-induced full thickness macular hole (FTMH) with delayed spontaneous closure without surgical intervention.

Observations: A 14-year old male developed full thickness macular hole after momentary exposure to a high-power handheld blue laser device. The macular hole closed spontaneously over a long period of observation. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351355PMC
March 2019
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Inverted Internal Limiting Membrane Technique Maintains Macular Hole Closure in Retinal Detachment Following Macular Hole Repair.

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):167-169

Retina Institute, Eye Foundation Hospitals, Lagos, Nigeria.

Recent advances in macular hole surgery have significantly improved the rates of anatomical success. One important advance is the dye-assisted peeling of the internal limiting membrane (ILM) around the hole. In large holes (<400 μ), sometimes, ILM peeling alone is not enough to achieve closure, and this may be improved by inverting part of the peeled membrane and using it to cover the macular hole or inverting and tucking the ILM flap into the hole. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_354_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348937PMC

A Heart-Shaped Fovea After Macular Hole Repair.

JAMA Ophthalmol 2019 Feb 14;137(2):e185820. Epub 2019 Feb 14.

Clinique Jules Verne, Institut Ophtalmologique de l'Ouest, Nantes, France.

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http://dx.doi.org/10.1001/jamaophthalmol.2018.5820DOI Listing
February 2019

Bilateral Acute Angle-Closure Glaucoma after Macular Hole Surgery.

Korean J Ophthalmol 2019 02;33(1):101-102

Department of Ophthalmology, Keimyung University School of Medicine, Daegu, Korea.

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http://dx.doi.org/10.3341/kjo.2018.0061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372387PMC
February 2019
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Predictive Model for Macular Hole Closure Speed: Insights From Intraoperative Optical Coherence Tomography.

Transl Vis Sci Technol 2019 Jan 6;8(1):18. Epub 2019 Feb 6.

The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.

Purpose: To establish a predictive model of macular hole (MH) closure speed.

Methods: This study was a post hoc analysis of eyes that underwent full-thickness MH repair in the prospective PIONEER intraoperative optical coherence tomography (iOCT) study. The Bioptigen SDOIS system was used for iOCT imaging. Read More

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http://dx.doi.org/10.1167/tvst.8.1.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366005PMC
January 2019
2 Reads

A Double Inverted Flap Surgical Technique for the Treatment of Idiopathic Lamellar Macular Hole Associated with Atypical Epiretinal Membrane.

Ophthalmologica 2019 Feb 8:1-10. Epub 2019 Feb 8.

Department of Ophthalmology, University of Padova, Padova, Italy.

Objectives: To propose a new technique of a double inverted epiretinal membrane (ERM) and internal limiting membrane (ILM) flap (double flap group) for the treatment of idiopathic lamellar macular hole (LMH) with atypical ERM (AERM) and to compare surgical outcomes to those of the standard technique of ERM and ILM peeling of the fovea including LMH (control group).

Methods: AERM was tomographically defined as a medium reflective thickened membrane above the retinal fiber layers without retinal traction signs. A series of patients affected by LMH with AERM were recruited. Read More

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http://dx.doi.org/10.1159/000496297DOI Listing
February 2019

Effect of Ocriplasmin on objectively assessed retinal function after treatment of vitreomacular diseases.

Acta Ophthalmol 2019 Feb 7. Epub 2019 Feb 7.

Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.

Background: The scope of the study was the functional assessment of possible effects of intravitreally injected ocriplasmin using electroretinographical (ERG) examinations.

Methods: Seven subjects suffered from pathologies within the label of ocriplasmin (Jetrea ) were examined in the study. An extended international society for clinical electrophysiology of vision ERG protocol was used for baseline recordings (before treatment) and was repeated for comparison 3 months after treatment with intravitreally injected ocriplasmin. Read More

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http://dx.doi.org/10.1111/aos.14030DOI Listing
February 2019