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Prog Retin Eye Res 2018 Dec 8. Epub 2018 Dec 8.

Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. Electronic address:

A posterior staphyloma is an outpouching of a circumscribed region of the posterior fundus and has been considered a hallmark of pathologic myopia. Occurring in highly myopic eyes, it is histologically characterized by a relatively abrupt scleral thinning starting at the staphyloma edge, a pronounced de-arrangement of scleral collagen fibrils and a marked choroidal thinning, which is the most marked at the staphyloma edge and which occurs in addition to the axial elongation-associated choroidal thinning. Besides in highly myopic eyes, a posterior staphyloma can be found in non-highly myopic eyes in association with retinitis pigmentosa or localized defects of Bruch's membrane in the cases of which it is not associated with a marked choroidal thinning. Read More

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.

Neovascularization in cancer or retinopathy is driven by pathological changes that foster abnormal sprouting of endothelial cells. Mouse genetic studies indicate that the stress-induced small GTPase RhoB is dispensable for normal physiology but required for pathogenic angiogenesis. In diabetic retinopathy, retinopathy of prematurity (ROP) or age-related wet macular degeneration (AMD), progressive pathologic anatomic changes and ischemia foster neovascularization are characterized by abnormal sprouting of endothelial cells. Read More

Acta Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Department of Vitreoretinal Surgery, The Rotterdam Eye Hospital, Rotterdam, the Netherlands.

Purpose: Unremoved vitreoschisis-induced vitreous cortex remnants (VCR) are associated with macular pathology. When present on the retinal periphery, they may play a role in proliferative vitreoretinopathy and retinal detachment after vitrectomy. Existing instruments for their removal involve substantial risk of iatrogenic retinal damage. Read More

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5847-5853

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Purpose: To differentiate the four layers of the retinal vessel network in the human macula and examine their morphologic features using high-resolution optical coherence tomography angiography (HR-OCTA).

Methods: Macular areas measuring 464 × 464 pixels of 10 right eyes of 10 healthy subjects without ocular disease were scanned 10 times using a HR-OCTA device. Averaged OCTA images were created. Read More

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5836-5846

Allergan plc, Irvine, California, United States.

Purpose: DARPin molecules are a novel class of small proteins that contain engineered ankyrin repeat domain(s) and bind to target proteins with high specificity and affinity. Abicipar-pegol (abicipar), a DARPin molecule targeting vascular endothelial growth factor-A (VEGF-A), is currently under evaluation in patients with age-related macular degeneration. The pharmacodynamic properties of abicipar were characterized using in vivo and in vitro assays. Read More

Hum Mol Genet 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.

The macula, located near the center of the retina in the human eye, is responsible for providing critical functions, such as central, sharp vision. Structural changes in the macula are associated with many ocular diseases, including age-related macular degeneration (AMD) and glaucoma. Although macular thickness is a highly heritable trait, there are no prior reported genome-wide association studies (GWASs) of it. Read More

Int J Retina Vitreous 2018 5;4:44. Epub 2018 Dec 5.

1Vitreous Retina Macula Consultants of New York, 460 Park Ave., New York, NY 10022 USA.

Background: Aneurysmal type 1 neovascularization (AT1) is a term recently introduced to better describe the aneurysmal dilatation that may arise from neovascular lesions, more commonly known as polypoidal choroidal vasculopathy. The proposed term, AT1, includes an expanded clinical spectrum of aneurysmal (polypoidal) lesions observed in both different ethnicities and associated with varied clinical phenotypes.

Case Presentation: A 61-year-old woman of European descent was referred for a new, asymptomatic retinal hemorrhage found on routine examination. Read More

J Biol Eng 2018 4;12:29. Epub 2018 Dec 4.

1Morgridge Institute for Research, Madison, WI USA.

The retinal pigment epithelium (RPE) is essential to the health of the retina and the proper functioning of the photoreceptors. The RPE is rich in melanosomes, which contain the pigment melanin. Changes in RPE pigmentation are seen with normal aging and in diseases such as albinism and age-related macular degeneration. Read More

J Inflamm (Lond) 2018 4;15:26. Epub 2018 Dec 4.

1Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, 1163, Tatemachi, Hachioji, Tokyo, 193-0998 Japan.

Background: Intravitreal ranibizumab injection (IRI) is effective for patients with exudative age-related macular degeneration (AMD) and decreases intraocular levels of vascular endothelial growth factor (VEGF), but VEGF receptor intraocular dynamics after IRI are unclear. Therefore, we evaluated changes in the aqueous humor levels of soluble vascular endothelial growth factor receptor (sVEGFR)-1, sVEGFR-2, and their ligands for these receptors (VEGF) patients with AMD receiving IRI.

Methods: The subjects were 24 patients with AMD (24 eyes) who received 3 doses of IRI at monthly intervals. Read More

PLoS One 2018 11;13(12):e0207435. Epub 2018 Dec 11.

Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Purpose: To evaluate structural changes in the choroid among patients with diabetic macular edema (DME), with varying grades of diabetic retinopathy (DR), using enhance depth imaging spectral domain optical coherence tomography (EDI SD-OCT) scans.

Methods: A cross-sectional study was conducted on 82 eyes with DR and DME and 86 healthy control eyes. Eyes with DME were classified according to the severity of DR as per the international DR severity scale. Read More

PLoS One 2018 11;13(12):e0208980. Epub 2018 Dec 11.

Department of Ophthalmology, University Medical Center Goettingen, Germany.

Purpose: To investigate the feasibility and diagnostic benefit of routinely performed preoperative macular spectral-domain (SD-) optical coherence tomography (OCT) for the detection of macular pathology in patients with normal biomicroscopic funduscopy prior to cataract surgery.

Methods: Prospective, single center study. A total of 162 eyes of 123 consecutive patients referred for cataract surgery with a visual acuity better than 20/100, absence of macular symptoms such as metamorphopsia, no history of previous intravitreal procedures and a normal funduscopic appearance on biomicroscopy underwent an additional SD-OCT-examination prior to cataract surgery. Read More

PLoS One 2018 11;13(12):e0208254. Epub 2018 Dec 11.

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: This study investigated the association of central macular thickness (CMT) and macular volume (MV) with severity of Behçet uveitis in the absence of macular edema (ME).

Methods: This retrospective, interventional study included a total 131 treatment-naïve Behçet patients with varying degree of uveitis in the absence of ME. The mean CMT and MV were obtained by spectral domain optical coherence tomography (SD ODT). Read More

Clin Ophthalmol 2018 15;12:2337-2345. Epub 2018 Nov 15.

Newcastle Eye Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK,

Background: An increasingly elderly population with a corresponding increase in ophthalmic conditions has led to increased pressure on hospital eye services (HES). In this study, we evaluated the use of a medical retina virtual clinic (MRVC), which has expanded into assessing all new medical retina referrals, where the need for urgent treatment was not clear.

Methods: Retrospective analysis of all new patients who were seen in the MRVC between April 2016 and May 2018. Read More

Clin Ophthalmol 2018 14;12:2323-2329. Epub 2018 Nov 14.

Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan,

Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy.

Subjects And Methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate. Read More

Gac Med Mex 2018 ;154(Supp 2):S30-S35

Dirección de Investigación y Enseñanza, Hospital Juárez de México, Ciudad de México, México.

Background: Parafoveal capillary density changes have not been characterized in type 2 diabetics without retinopathy.

Objective: To compare parafoveal capillary density between healthy subjects, and diabetics with and without retinopathy.

Method: Observational, prospective, transversal and comparative study; subjects without diabetes (group 1), diabetics without retinopathy (group 2), with retinopathy (group 3) and with diabetic macular edema (group 4), without macular ischemia, were included. Read More

Pol Merkur Lekarski 2018 Nov;45(269):195-197

5 Military Clinical Hospital with Polyclinic in Cracow, Poland.

Macular edema is a rare complication that can occur under the influence of light. Damage occurs as a result of focusing the light beam on the macula. A 23-year-old patient reported to the hospital due to a sudden reduction in visual acuity of the left eye after visual contact with a geodetic laser at work. Read More

Retin Cases Brief Rep 2018 Dec 6. Epub 2018 Dec 6.

Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

Purpose: To report a case of serous macular detachment in a patient with Waldenstrom macroglobulinemia treated with ibrutinib.

Methods: The patient underwent a complete ophthalmic examination and imaging at presentation and at follow-up visits up to 13 months.

Results: At presentation, there were serous macular detachments bilaterally with no dye leakage on fluorescein angiography or vasculature abnormalities on optical coherence tomography angiography. Read More

J Glaucoma 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology and Visual Sciences, Federal University of Sa[Combining Tilde]o Paulo, Sa[Combining Tilde]o Paulo, Brazil.

Purpose: To perform a glaucoma work-up in infants with congenital Zika syndrome (CZS).

Patient And Methods: This cross-sectional study included 188 eyes of 107 children (1.1 ± 0. Read More

Ophthalmology 2018 Dec 6. Epub 2018 Dec 6.

Marsden Eye Specialists, Parramatta, Australia.

Purpose: To investigate the incidence, characteristics and baseline predictors of poor visual outcomes in eyes with neovascular age-related macular degeneration (nAMD) receiving intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents in daily clinical practice.

Design: Observational study.

Participants: Treatment-naïve eyes starting anti-VEGF therapy for nAMD between 2007 and 2012 tracked in the Fight Retinal Blindness! registry. Read More

Mol Ther 2018 Nov 13. Epub 2018 Nov 13.

Adverum Biotechnologies, Menlo Park, CA, USA. Electronic address:

Inhibition of vascular endothelial growth factor, a key contributor to the choroidal neovascularization associated with wet age-related macular degeneration, is the mode of action of several approved therapies, including aflibercept, which requires frequent intravitreal injections to provide clinical benefit. Lack of compliance with the dosing schedule may result in recurrence of active wet macular degeneration, leading to irreversible vision impairment. Gene therapy providing sustained anti-vascular endothelial growth factor levels in the retina following a single injection could drastically reduce the treatment burden and improve visual outcomes. Read More

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):918-922

Tianjin Medical University Eye Hospital, College of Optometry and Ophthalmology, Tianjin Medical University Eye Institute, Tianjin 300384, China.

To report the clinical outcomes and safety profile of 27G(+) transconjunctival sutureless vitrectomy (TSV) in eyes with posterior segment disease. Prospective, interventional case series. Eyes undergoing 27G(+) TSV for a vitreoretinal surgery indication were included from Dec 2015 to Mar 2016. Read More

BMC Ophthalmol 2018 Dec 10;18(1):315. Epub 2018 Dec 10.

Department of Ophthalmology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.

Background: Despite the potential usefulness of optical coherence tomography angiography in retinal and optic disc conditions, the reliability of the imaging modality remains unclear. This study set out to measure the microvascular density of macula and optic disc by mean of optical coherence tomography angiography and report the repeatability of the vessel density measurements.

Methods: Cross sectional observational cohort study. Read More

Mult Scler 2018 Dec 11:1352458518817987. Epub 2018 Dec 11.

Department of Neurology, Hacettepe University, Ankara, Turkey.

Background:: The extent of neurodegeneration in the earliest stages of central nervous system (CNS) demyelination is not known. Optical coherence tomography (OCT) is a powerful tool to study neurodegeneration in demyelinating disorders.

Objectives:: To study neuroaxonal loss in the retina of individuals with radiologically isolated syndrome (RIS) and investigate whether OCT measurements are associated with brain volumetrics and clinical conversion to multiple sclerosis (MS). Read More

Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.

Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.

Background: The aim of this study was to examine the influence of B-scan averaging on choroidal thickness using wide-field enhanced-depth imaging optical coherence tomography.

Methods: Six high-resolution trans-foveal horizontal enhanced-depth imaging line scans (spanning a 60° field) were acquired consecutively from the right eye of 10 healthy adults (mean age 30 ± 5 years), with each line scan an average of 10, 20, 30, 40, 50 or 100 B-scans, using the automated real-time image averaging and follow-up features of a Spectralis device. The impact of B-scan averaging on regional measures of wide-field choroidal thickness (across macular and peripheral regions) and their accuracy was investigated, assuming that averaging 100 B-scans would provide the most accurate estimate of choroidal thickness. Read More

Am J Ophthalmol Case Rep 2019 Mar 10;13:28-31. Epub 2018 Nov 10.

Howard University, 2041 Georgia Avenue NW, Washington DC, USA.

Purpose: We report 2 cases of young diabetic mothers with pre-eclampsia and no previously documented visual deficits prior to pregnancy who were found to have profound retinal circulation loss during the postpartum period.

Observations: Fluorescein angiogram in both cases documented profound ischemia of retinal and macular circulation with resulting severe vision loss, leading to legal blindness.

Conclusions And Importance: While Pre-eclampsia and Eclampsia are well known clinical entities with potentially grave effects on both the mother and child, there is little information about the possible combined effects of diabetes and Pre-eclampsia/Eclampsia on the retinal circulation. Read More

BMJ Open Ophthalmol 2018 25;3(1):e000195. Epub 2018 Oct 25.

Section of Specialized Endocrinology, Oslo University Hospital, Oslo, Norway.

Objective: To estimate the macular ganglion cell complex (GCC) asymmetry in patients with suprasellar tumours, to compare its diagnostic performance to the nasal GCC thickness and visual field (VF) and to investigate how the parameters correlate with magnetic resonance imaging (MRI) findings.

Methods And Analysis: Cross-sectional study of patients with suprasellar tumours affecting the optic chiasm. Macular optical coherence tomography (OCT) scans were evaluated for nasal GCC sector thinning and loss of normal GCC asymmetry between corresponding nasal-temporal sectors. Read More

Int J Retina Vitreous 2018 30;4:45. Epub 2018 Nov 30.

Gavin Herbert Eye Institute, University of California Irvine, 850 Health Sciences Road, Irvine, CA 92697 USA.

Background: Prader-Willi syndrome (PWS) is a genetic disease caused by loss of expression of the paternally inherited copy of several genes on the long arm of chromosome 15. Ophthalmic manifestations of PWS include strabismus, amblyopia, nystagmus, hypopigmentation of the iris and choroid, diabetic retinopathy, cataract and congenital ectropion uvea. An overlap between PWS and oculocutaneous albinism (OCA) has long been recognized and attributed to deletion of OCA2 gene located in PWS critical region (PWCR). Read More

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.

Purpose: To assess Descemet's membrane endothelial keratoplasty (DMEK) without performing a peripheral iridotomy (PI) prior to or during surgery ("PI-less DMEK").

Materials And Methods: This retrospective study included consecutive patients that underwent PI-less DMEK by a single surgeon (E.L) between February 2016 and February 2017 at the Rabin Medical Center, a Tertiary Hospital. Read More

Appl Psychophysiol Biofeedback 2018 Nov 30. Epub 2018 Nov 30.

Department of Ophthalmology, Semmelweis University, Mária u. 39, Budapest, 1085, Hungary.

Biofeedback training has been used to improve fixation stability in subjects with central vision loss, but the psychophysiological mechanisms underlying the functional improvements resulted was not reported. The aim of this study was to investigate the effects of microperimetric biofeedback training on different visual functions and self-reported quality of vision in subjects with age-related macular degeneration. This case-control study included six subjects (72. Read More

Acta Neurol Belg 2018 Nov 30. Epub 2018 Nov 30.

Department of Neurology, Keçiören Training and Research Hospital, Ankara, Turkey.

The aim of the study was to measure the thicknesses of the inner retinal segments and optic nerve head (ONH) parameters in migraineurs and patients with tension-type headache (TTH) in headache-free period using swept source optical coherence tomography (SS-OCT) and to compare the outcomes with each other and those of healthy subjects. The study population consisted of 23 migraineurs, 22 TTH patients, and 25 controls with a best-corrected visual acuity of 20/20 and without a history of systemic or ocular disease. Macular ganglion cell inner plexiform layer (mGCIPL), macular ganglion cell complex (mGCC), circumpapillary retinal nerve fiber layer (cpRNFL), and ONH parameters were evaluated using SS-OCT, and the areas under the receiver-operating characteristic (ROC) curves were calculated to determine the ability of these parameters to distinguish between the patient and normal eyes. Read More

Ophthalmologe 2018 Nov 30. Epub 2018 Nov 30.

Augenklinik, Konventhospital der Barmherzigen Brüder Linz, Seilerstätte 2, 4021, Linz, Österreich.

In the literature various causes of opacification of hydrophilic lenses have been described. Pronounced opacity is a complication that must be taken seriously because it can lead to explantation or exchange of the intraocular lens (IOL). The calcification of hydrophilic IOLs is often made responsible for an explantation. Read More

Ophthalmol Retina 2018 Oct 2;2(10):1021-1027. Epub 2018 Jun 2.

Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland.

Purpose: To identify the development and progression of macular retinal pigment epithelial atrophy in eyes with neovascular (CNV) age-related macular degeneration (AMD) and to correlate with visual acuity (VA).

Design: Cohort study.

Participants: Age-Related Eye Disease Study 2 (AREDS2) participants with intermediate AMD enrolled in a randomized controlled clinical trial of oral supplements. Read More

Rom J Ophthalmol 2018 Jul-Sep;62(3):246-249

Department of Ophthalmology, Private Yeni Sevgi Hospital, Hatay, Turkey.

Gyrate atrophy (GA) of the fundus is a rare, progressive metabolic disease secondary to the deficiency of the pyridoxal phosphate-dependent enzyme, ornithine aminotransferase. GA may lead to cystoid macular edema (CME) resulting from chronic inflammation. We aimed to report a child case with CME secondary to gyrate atrophy. Read More

Rom J Ophthalmol 2018 Jul-Sep;62(3):222-227

Ophthalmology Department, Bucharest University Emergency Hospital, Bucharest, Romania.

To present a series of 2 cases of central serous chorioretinopathy and the changes in the macular pigment optical density during the evolution of the disease. A 32-year-old patient presented himself for blurred vision on his LE. The SD OCT imaging revealed serous macular detachment of the neurosensory retina on the LE. Read More

Rom J Ophthalmol 2018 Jul-Sep;62(3):217-221

Anatomy Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Serpiginous choroiditis represents an inflammation, often asymmetric, situated at the level of the inner choroid, which is related to the retinal pigment epithelium and the choriocapillaris. It is known as a primarily idiopathic, but there are authors who consider it an autoimmune process. Many times, fundus autofluorescence is the investigation which is guiding the diagnosis, the management, also the follow-up together with the determination of the progressive visual prognosis. Read More

Rom J Ophthalmol 2018 Jul-Sep;62(3):212-216

Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

To evaluate the effect of intravitreal bevacizumab (IVB) injection on central macular thickness (CMT) in patients with diabetic macular edema (DME) associated with epiretinal membrane (ERM) and compare the results to those with DME without ERM. 54 eyes of 54 patients with DME were included in this prospective comparative case series. Twenty-eight patients had ERM. Read More

Am J Ophthalmol Case Rep 2019 Mar 13;13:13-15. Epub 2018 Nov 13.

Doheny Eye Institute, Los Angeles, CA, USA.

Purpose: Peripapillary vascular alterations have been classically described as hallmarks of Leber's Hereditary Optic Neuropathy (LHON). We recently demonstrated microvascular pathology involving the macula in patients affected with chronic LHON using optical coherence tomography angiography (OCTA). Macular vascular pathology in acute LHON has not previously been reported. Read More

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(4):176-182

Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.

The aim of this study was to investigate the efficacy of Intravitreal Injection of Bevacizumab (IVB) in patients with Central Serous Chorioretinopathy (CSC) compared to the control group, after four months of injection. In this study, 30 eyes of 30 patients with CSC, who were in the age range of 23 to 50 years old (70% male subject) were included. Eligible patients were randomly allocated to the intervention (n = 15) and control groups (n = 15). Read More

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(4):169-175

Department of Ophthalmology, Dokuz Eylul University, İzmir, Turkey.

Macular Edema (ME) is a common complication, leading to severe vision loss in patients with Non-Infectious Uveitis (NIU). The treatment of uveitic ME is still very challenging for many ophthalmologists. Various agents, such as corticosteroids, anti-vascular endothelial growth factors, and immune-modulators, have been used for combatting uveitic ME. Read More

Oman J Ophthalmol 2018 Sep-Dec;11(3):304-305

Department of Ophthalmology, BPS Government Medical College for Women, Sonepat, Haryana, India.

Oman J Ophthalmol 2018 Sep-Dec;11(3):277-279

Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

This report describes a lamellar macular hole formation subsequent to intravitreal bevacizumab injection for the treatment of choroidal neovascularization (CNV) by age-related macular degeneration. A 67-year-old woman with bilateral CNV underwent 3 monthly intravitreal bevacizumab injections in her both eyes. One month after the third bilateral injection, vision loss happened. Read More

Oman J Ophthalmol 2018 Sep-Dec;11(3):254-258

Department of Biostatistics, Dr. R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Aim: The aim of this study is to compare the efficacy of intravitreal bevacizumab and posterior subtenons triamcinolone acetate in the management of diffuse diabetic macular edema (DME) and to evaluate their efficacy as an adjunct to modified grid laser in management of DME.

Design: This was a prospective, randomized clinical trial of 30 patients.

Materials And Methods: A total of 30 patients attending the medical ophthalmology clinic at a tertiary care hospital were included in the study. Read More

Oman J Ophthalmol 2018 Sep-Dec;11(3):248-253

Department of Ophthalmology, University College of Medical Sciences and GTB Hospital, Delhi University, New Delhi, India.

Background And Objective: The objective of the study was to compare the efficacy of intravitreal bevacizumab (IVB) as monotherapy versus combination with modified macular grid (MMG) laser photocoagulation in the primary treatment of diffuse diabetic macular edema (DDME).

Materials And Methods: A prospective randomized trial was carried out in sixty eyes with DDME after Institutional Ethical clearance. Group A received three doses of IVB at a 1-month interval. Read More

Oman J Ophthalmol 2018 Sep-Dec;11(3):241-247

Senior Resident, Department of Ophthalmology, AIIMS, Raipur (CG), Chhattisgarh, India.

Purpose: An assessment of variation in Macular Volume and RNFL Thickness in myopes using OCT, and their significance for early diagnosis of Primary Open Angle Glaucoma(POAG).

Materials And Method: Total of 122 eyes of 61 Indian Myopic subjects of both sex and various age groups underwent retinal nerve fiber layer thickness, macular volume in 6mm analysis by Rtvue Avanti SD-OCT, Optovue Technology V6.1. Read More

Eye (Lond) 2018 Nov 30. Epub 2018 Nov 30.

Gloucestershire Retinal Research Group, Cheltenham General Hospital, Cheltenham, UK.

Background: Annually 2.7 million individuals are offered screening for diabetic retinopathy (DR) in England. Spectral-Domain Optical Coherence Tomography (SD-OCT) has the potential to relieve pressure on NHS services by correctly identifying patients who are screen positive for maculopathy on two-dimensional photography without evidence of clinically significant macular oedema (CSMO), limiting the number of referrals to hospitals. Read More

Br J Ophthalmol 2018 Dec 1. Epub 2018 Dec 1.

Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

Aims: To compare 24 months outcomes of eyes with retinal angiomatous proliferations (RAPs) treated with antivascular endothelial growth factor (anti-VEGF) with a group of controls diagnosed with other neovascular age-related macular degeneration (nAMD) subtypes in a real-world setting.

Methods: Treatment-naïve nAMD eyes that commenced anti-VEGF between January 2006 and November 2015 were identified from a registry of nAMD treatment outcomes. Cases were defined as eyes diagnosed with RAP. Read More

Br J Ophthalmol 2018 Dec 1. Epub 2018 Dec 1.

Department of Ophthalmology, Horngren Family Vitreoretinal Center, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.

Purpose: To determine if final visual acuity (VA) is affected by duration of macular detachment (DMD) within the first week of macula-off retinal detachment (RD).

Methods: This is a retrospective study of eyes that underwent repair within 7 days with vitrectomy or vitrectomy with scleral buckle for macula-off RD at Stanford University Hospital between 1 May 2007 and 1 May 2017. A generalised linear model was constructed using DMD, postoperative lens status, preoperative VA, patient age and surgeon as the independent variables and the final VA as the dependent variable. Read More

J Pharmacol Sci 2018 Nov 20. Epub 2018 Nov 20.

Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy; Center for Research in Ocular Pharmacology, CERFO University of Catania, Catania, Italy; Regional Pharmacovigilance Centre of Catania, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy.

Introduction: Systematic review of real-world studies about repeated dexamethasone intravitreal implant (DEXi) 0.7 mg in diabetic macular edema management, in order to identify the effective window of time occurring between injections, the critical evaluation of efficacy of the treatment, and the relative long-term safety in the real life setting.

Methods: Literature databases such as PubMed, SCOPUS, and EMBASE were used to identify reports including DEX implant injections. Read More

Can J Ophthalmol 2018 Dec 2;53(6):637-638. Epub 2018 Apr 2.

Department of Ophthalmology, Singleton Hospital, Swansea, Wales.. Electronic address:

Objective: To canvass views about whether argon laser pretreatment to ischemic areas of retina would be acceptable if it resulted in a reduced burden of intravitreal injections.

Method: A postal survey was mailed to all 813 patients under the care of the diabetic eye clinic at Singleton Hospital with 10 questions, explanatory information, and a stamp-addressed envelope available for returning completed questionnaires.

Results: Patients were strongly supportive (9. Read More

Can J Ophthalmol 2018 Dec 2;53(6):632-636. Epub 2018 Apr 2.

Department of Ophthalmology, Medical University Innsbruck, Innsbruck, Austria.

Objective: We compared visual and macular morphological outcomes after epiretinal membrane (ERM) peeling, with and without IVTA treatment.

Design: Interventional, retrospective, consecutive case-control study.

Participants: Forty-one eyes of 41 participants (17 men, 24 women) were included. Read More