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    Causes of irreversible unilateral or bilateral blindness in the Al Baha region of the Kingdom of Saudi Arabia.
    Saudi J Ophthalmol 2016 Jul-Sep;30(3):189-193. Epub 2016 Jun 28.
    Eye and Laser Surgery Center, Bahrain.
    Purpose: To determine the causes of irreversible unilateral and bilateral blindness that cannot be rehabilitated medically, optically nor surgically in Al Baha province, Kingdom of Saudi Arabia.

    Methods: There were a retrospective chart review and examination of patients presenting to King Fahad Hospital Al Baha, Saudi Arabia, with unilateral or bilateral blindness from June 2011 to September 2011. Blindness was defined as best corrected visual acuity (BCVA) of less than 0. Read More

    En Face Doppler Optical Coherence Tomography Measurement of Total Retinal Blood Flow in Diabetic Retinopathy and Diabetic Macular Edema.
    JAMA Ophthalmol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge2Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge.
    Importance: Alterations in ocular blood flow play an important role in the pathogenesis and progression of diabetic retinopathy (DR). However, the measurement of retinal blood flow in clinical studies has been challenging. En face Doppler optical coherence tomography (OCT) provides an effective method for measuring total retinal blood flow (TRBF) in the clinic. Read More

    QUANTIFICATION OF INTRARETINAL HARD EXUDATES IN EYES WITH DIABETIC RETINOPATHY BY OPTICAL COHERENCE TOMOGRAPHY.
    Retina 2017 Feb 10. Epub 2017 Feb 10.
    *Doheny Eye Institute, Los Angeles, California; †Department of Ophthalmology, University of Bonn, Bonn, Germany; ‡Carson McBeath and Boswell Inc, South Coast Retina Center, Long Beach, California; and §Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California.
    Purpose: To evaluate the reproducibility of intraretinal hard exudate (HE) quantification from spectral domain optical coherence tomography (SD-OCT) images of eyes with diabetic retinopathy (DR).

    Methods: Cases with diabetic macular edema were enrolled. The area of HE obtained by B-scan segmentation was compared with the area obtained by en face segmentation. Read More

    EFFECT OF AN INTRAVITREAL DEXAMETHASONE IMPLANT ON DIABETIC MACULAR EDEMA AFTER CATARACT SURGERY.
    Retina 2017 Feb 10. Epub 2017 Feb 10.
    *IIS-Aragon, Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain; †University of Zaragoza, Zaragoza, Spain; ‡Department of Ophthalmology, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia; §Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand; and ¶Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada.
    Purpose: To analyze the effects of a dexamethasone intravitreal implant (DEX; Ozurdex 700 μg; Allergan) administered immediately after cataract surgery in diabetic patients.

    Methods: This prospective, single-arm, open label study (NCT01748487 at ClinicalTrials.gov) involved Type 2 diabetic patients with at least mild diabetic retinopathy (DR) who underwent cataract surgery and DEX insertion after phacoemulsification, and intraocular lens implantation were enrolled. Read More

    CHOROIDAL THICKNESS IN DIABETIC RETINOPATHY ASSESSED WITH SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY.
    Retina 2017 Feb 10. Epub 2017 Feb 10.
    *Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; †Faculty of Medicine, University of Coimbra, Coimbra, Portugal; ‡Department of Ophthalmology, Coimbra University Hospital, Coimbra, Portugal; §Association for Innovation and Biomedical Research on Light, Coimbra, Portugal; and ¶School of Allied Health Technologies, Polytechnic Institute of Porto, Porto, Portugal.
    Purpose: To compare the choroidal thickness (CT) of diabetic eyes (different stages of disease) with controls, using swept-source optical coherence tomography.

    Methods: A multicenter, prospective, cross-sectional study of diabetic and nondiabetic subjects using swept-source optical coherence tomography imaging. Choroidal thickness maps, according to the nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, were obtained using automated software. Read More

    Significant Bilateral Response in Diabetic Macular Edema After Single Unilateral Intravitreal Aflibercept Injection.
    Ophthalmic Surg Lasers Imaging Retina 2017 02;48(2):167-169
    A 61-year-old patient with bilateral, treatment-naïve, diffuse diabetic macular edema (DME) that had been progressing during the previous 12 months received a single intravitreal injection of aflibercept (Eylea; Regeneron, Tarrytown, NY) to the left eye. At 2-week follow-up, noticeable bilateral improvement of the DME was observed by spectral-domain optical coherence tomography imaging with commensurate improvement of visual acuity to 20/30 bilaterally. [Ophthalmic Surg Lasers Imaging Retina. Read More

    Efficacy of the Intravitreal Sustained-Release Dexamethasone Implant for Diabetic Macular Edema Refractory to Anti-Vascular Endothelial Growth Factor Therapy: Meta-Analysis and Clinical Implications.
    Ophthalmic Surg Lasers Imaging Retina 2017 Feb;48(2):160-166
    Background And Objective: To assess the effect on best-corrected visual acuity (BCVA) and efficacy of the intravitreal sustained-release 0.7 mg dexamethasone implant (Ozurdex; Allergan, Irvine, CA) in patients with recalcitrant diabetic macular edema (DME).

    Patients And Methods: Meta-analysis utilizing the MOOSE framework and a random effects model. Read More

    Considerations for management of patients with diabetic macular edema: Optimizing treatment outcomes and minimizing safety concerns through interdisciplinary collaboration.
    Diabetes Res Clin Pract 2017 Jan 29;126:1-9. Epub 2017 Jan 29.
    Kantonsspital Baselland, Eye Clinic, Liestal, Switzerland; University of Basel, Basel, Switzerland.
    Diabetes is a growing worldwide epidemic and a leading cause of blindness in working-age people around the world. Diabetic retinopathy (DR) and diabetic macular edema (DME) are common causes of visual impairment in people with diabetes and often indicate the presence of diabetes-associated preclinical micro- and macrovascular complications. As such, patients with DR and DME often display complex, highly comorbid profiles. Read More

    An anomaly detection approach for the identification of DME patients using spectral domain optical coherence tomography images.
    Comput Methods Programs Biomed 2017 Feb 4;139:109-117. Epub 2016 Nov 4.
    LE2I, UMR6306, CNRS, Arts et Métiers, Université de Bourgogne-Franche Comté, F-21000 Dijon, France; Center for Intelligent Signal and Imaging Research (CISIR), EEE Department, Universiti Teknologi Petronas, 32610 Seri Iskandar, Perak, Malaysia.
    This paper proposes a method for automatic classification of spectral domain OCT data for the identification of patients with retinal diseases such as Diabetic Macular Edema (DME). We address this issue as an anomaly detection problem and propose a method that not only allows the classification of the OCT volume, but also allows the identification of the individual diseased B-scans inside the volume. Our approach is based on modeling the appearance of normal OCT images with a Gaussian Mixture Model (GMM) and detecting abnormal OCT images as outliers. Read More

    Comparison of Efficacy and Side Effects of Multispot Lasers and Conventional Lasers for Diabetic Retinopathy Treatment.
    Turk J Ophthalmol 2017 Jan 17;47(1):34-41. Epub 2017 Jan 17.
    Marmara University Faculty of Medicine, Department of Ophthalmology, İstanbul, Turkey.
    Panretinal photocoagulation (PRP) is a standard treatment for proliferative diabetic retinopathy. Conventional laser (CL) therapy is performed in one or more sessions in single spot mode. Visual disabilities have been reported after treatment with CL, including central vision loss due to macular edema and peripheral visual field loss resulting from extensive inner retinal scarring. Read More

    Platform-Independent Cirrus and Spectralis Thickness Measurements in Eyes with Diabetic Macular Edema Using Fully Automated Software.
    Transl Vis Sci Technol 2017 Feb 7;6(1). Epub 2017 Feb 7.
    Department of Ophthalmology, Duke University, Durham, NC, USA.
    Purpose: We determine whether the automated segmentation software, Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP), can measure, in a platform-independent manner, retinal thickness on Cirrus and Spectralis spectral domain optical coherence tomography (SD-OCT) images in eyes with diabetic macular edema (DME) under treatment in a clinical trial.

    Methods: Automatic segmentation software was used to segment the internal limiting membrane (ILM), inner retinal pigment epithelium (RPE), and Bruch's membrane (BM) in SD-OCT images acquired by Cirrus and Spectralis commercial systems, from the same eye, on the same day during a clinical interventional DME trial. Mean retinal thickness differences were compared across commercial and DOCTRAP platforms using intraclass correlation (ICC) and Bland-Altman plots. Read More

    A Nonrandomized, Open-Label, Multicenter, Phase 4 Pilot Study on the Effect and Safety of ILUVIEN® in Chronic Diabetic Macular Edema Patients Considered Insufficiently Responsive to Available Therapies (RESPOND).
    Ophthalmic Res 2017 Feb 9. Epub 2017 Feb 9.
    AIBILI - Association for Innovation and Biomedical Research on Light and Image, University of Coimbra, Coimbra, Portugal.
    Purpose: The aim of this study was to assess the effectiveness and safety of ILUVIEN® in patients with chronic diabetic macular edema (DME) who were insufficiently responsive to prior therapies.

    Methods: This is a prospective, nonrandomized, multicenter, open-label, phase 4 pilot study assessing the effectiveness and safety of ILUVIEN® involving 12 patients insufficiently responsive to available therapies. Assessments were performed at screening, baseline, week 1, and months 1, 3, 6, 9, and 12. Read More

    Comparison of efficacy of intravitreal ranibizumab between non-vitrectomized and vitrectomized eyes with diabetic macular edema.
    Int Ophthalmol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Ophthalmology, Far Eastern Memorial Hospital, No. 21, Sect. 2, Nan-Ya South Road, Pan-Chiao District, New Taipei, 220, Taiwan.
    Purpose: To compare the efficacy of intravitreal ranibizumab between non-vitrectomized and vitrectomized eyes with diabetic macular edema (DME).

    Study Design: A retrospective, nonrandomized, and comparative study.

    Methods: From May 2013 to March 2016, 148 eyes of 148 patients with treatment-naïve center-involving DME were reviewed in one institution. Read More

    Comparison of 55° Wide-Field Spectral Domain Optical Coherence Tomography and Conventional 30° Optical Coherence Tomography for the Assessment of Diabetic Macular Edema.
    Ophthalmologica 2017 Feb 8. Epub 2017 Feb 8.
    Department of Ophthalmology, Inselspital, University Clinic Bern, Switzerland.
    Purpose: To compare conventional 30° spectral domain optical coherence tomography (SD-OCT) with 55° wide-field SD-OCT for the assessment of diabetic macular edema (DME).

    Methods: This study included 50 DME patients. Both 55° and 30° SD-OCT was conducted. Read More

    Optical coherence tomography angiography of macular telangiectasia type 1: Comparison with mild diabetic macular edema.
    Lasers Surg Med 2017 Feb 7. Epub 2017 Feb 7.
    Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 200080.
    Objective: The present study aimed to investigate the characteristics of macular telangiectasia type 1 (Mac tel type 1) using spectral-domain optical coherence tomography angiography (OCTA) and compare them with the characteristics of mild diabetic macular edema (DME), to provide a new objective method for quick clinical diagnosis and treatment.

    Methods: A retrospective comparative analysis of 9 Mac tel type 1, 15 DME, and 15 normal eyes was performed using fluorescein angiography, spectral-domain optical coherence tomography, and OCTA. The morphological changes, retinal vessel density, and nonperfused areas were evaluated using split-spectrum amplitude-decorrelation angiography algorithm. Read More

    Diabetic macular edema outcomes in eyes treated with fluocinolone acetonide 0.2 µg/d intravitreal implant: real-world UK experience.
    Eur J Ophthalmol 2017 Feb 6. Epub 2017 Feb 6.
    Newcastle Eye Centre, Royal Victoria Infirmary, Newcastle Upon Tyne - UK.
    Purpose: To conduct an observational, multicenter study to evaluate real-world clinical efficacy and safety of the 0.2 µg/day fluocinolone acetonide (FAc) implant in the treatment of patients with chronic diabetic macular edema (DME) in 3 large hospital ophthalmology departments in the United Kingdom.

    Methods: Fluocinolone acetonide implants were inserted into the study eyes following a suitable washout period; phakic eyes received FAc implant following cataract surgery. Read More

    Factors Associated with Worsening Proliferative Diabetic Retinopathy in Eyes Treated with Panretinal Photocoagulation or Ranibizumab.
    Ophthalmology 2017 Feb 1. Epub 2017 Feb 1.
    Loma Linda University Health Care, Loma Linda, California.
    Purpose: To compare rates and identify predictive factors for events that represent worsening of proliferative diabetic retinopathy (PDR) in eyes treated with panretinal photocoagulation (PRP) or ranibizumab.

    Design: Randomized clinical trial (55 United States sites).

    Participants: Three hundred ninety-four study eyes from 305 adults with PDR, visual acuity (VA) 20/320 or better, and no history of PRP. Read More

    Study of aqueous cytokines in patients with different patterns of diabetic macular edema based on optical coherence tomography.
    Int Ophthalmol 2017 Feb 3. Epub 2017 Feb 3.
    Department of Community Medicine, R. G. Kar Medical College and Hospital, 1, Kshudiram Bose Sarani, Kolkata, 700004, India.
    Purpose: To compare aqueous angiogenic and inflammatory cytokine concentrations in different patterns of diabetic macular edema (DME) based on optical coherence tomography (OCT).

    Methods: This prospective study was conducted between July 1, 2015, and March 31, 2016, for 9 months. Aqueous samples were obtained from 52 consecutive DME patients and 16 controls. Read More

    Highly Reproducible Au-Decorated ZnO Nanorod Array on a Graphite Sensor for Classification of Human Aqueous Humors.
    ACS Appl Mater Interfaces 2017 Feb 9. Epub 2017 Feb 9.
    Department of Medical Engineering, Graduate School, Kyung Hee University , Seoul 02447, Republic of Korea.
    Gold-decorated, vertically grown ZnO nanorods (NRs) on a flexible graphite sheet (Au/ZnONRs/G) were developed for surface-enhanced Raman scattering (SERS)-based biosensing to identify trace amounts of human aqueous humors. This Au/ZnONRs/G SERS-functionalized sensor was fabricated via two steps: hydrothermal synthesis-induced growth of ZnO NRs on graphite sheets for nanostructure fabrication, followed by e-beam evaporator-induced gold metallization on ZnONRs/G for SERS functionalization. The thickness of the Au layer and the height of the ZnO NRs for enhancing SERS performance were adjusted to maximize Raman intensity, and the optimized Au/ZnONRs/G nanostructures were verified by the electric finite element computational models to maximize the electric fields. Read More

    The Blood-Retinal Barrier in the Management of Retinal Disease: EURETINA Award Lecture.
    Ophthalmologica 2017 Feb 3. Epub 2017 Feb 3.
    AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal.
    Retinal diseases are the main causes of blindness in the Western world. Diabetic retinopathy and age-related macular degeneration continue to increase in prevalence and as main causes of vision loss. Intravitreal anti-VEGF and steroid injections have raised new expectations for their successful treatment. Read More

    Functional and Anatomical Outcomes in Patients With Serous Retinal Detachment in Diabetic Macular Edema Treated With Ranibizumab.
    Invest Ophthalmol Vis Sci 2017 Feb;58(2):797-800
    Department of Ophthalmology, Hôpital Avicenne, Bobigny, France 2Départment Hospitalo-Universitaire (DHU) Vision et Handicap, Department of Ophthalmology, Hôpital Pitié-Salpêtrière, Paris, France 4Centre Ophtalmologique d'Imagerie et de Laser, Paris, France.
    Purpose: To assess the effect of serous retinal detachment (SRD) on functional and anatomical outcomes in ranibizumab-treated patients with diabetic macular edema (DME).

    Methods: All consecutive ranibizumab-treated patients with SRD were included in this retrospective study. For each patient with SRD, a patient without SRD with the same baseline best-corrected visual acuity (BCVA) was randomly included for adjustment on their baseline BCVA. Read More

    Controversies in Using Off-Label Intravitreous Bevacizumab for Patients With Diabetic Macular Edema-Reply.
    JAMA Ophthalmol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Health Management and Policy, University of Michigan School of Public Health, Ann Arbor5Department of Industrial and Operations Engineering, University of Michigan, Ann Arbor6College of Engineering, Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor.

    The Early Treatment Diabetic Retinopathy Study historical review and relevance to today's management of diabetic macular edema.
    Curr Opin Ophthalmol 2017 Feb 1. Epub 2017 Feb 1.
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
    Purpose Of Review: To provide an historical review of the Early Treatment Diabetic Retinopathy Study (ETDRS) in the management of diabetic macular edema (DME), and to discuss its relevance to the management of DME.

    Recent Findings: The ETDRS reported that argon laser treatment is beneficial in the management of 'clinically significant' DME. The study provided guidelines for the treatment with focal and/or grid laser based on fluorescein angiographic patterns. Read More

    Gene therapy for diabetic retinopathy: Are we ready to make the leap from bench to bedside?
    Pharmacol Ther 2017 Jan 26. Epub 2017 Jan 26.
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia; Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia. Electronic address:
    Diabetic retinopathy (DR), a chronic and progressive complication of diabetes mellitus, is a sight-threatening disease characterized in the early stages by neuronal and vascular dysfunction in the retina, and later by neovascularization that further damages vision. A major contributor to the pathology is excess production of vascular endothelial growth factor (VEGF), a growth factor that induces formation of new blood vessels and increases permeability of existing vessels. Despite the recent availability of effective treatments for the disease, including laser photocoagulation and therapeutic VEGF antibodies, DR remains a significant cause of vision loss worldwide. Read More

    Restoration of photoreceptors in eyes with diabetic macular edema.
    Eur J Ophthalmol 2017 Jan 25. Epub 2017 Jan 25.
    Department of Ophthalmology, Istanbul Training and Research Hospital, Istanbul - Turkey.
    Purpose: To show the prognostic value of foveal microstructures using optical coherence tomography (OCT) for the restoration of inner segment/outer segment (IS/OS) junction layer following resolution of diabetic macular edema (DME).

    Methods: Forty-one eyes of 39 patients with IS/OS damage at the time of DME that showed complete resolution of DME were included. Eyes were divided into 2 groups based on the IS/OS integrity at final visit, when edema was completely resolved: always damage group (damage at baseline and at final visit) and initial damage group (damage only at baseline). Read More

    Aniseikonia in various retinal disorders.
    Graefes Arch Clin Exp Ophthalmol 2017 Jan 25. Epub 2017 Jan 25.
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.
    Purpose: The purpose was to quantify and compare the severity of aniseikonia in patients undergoing vitrectomy for various retinal disorders.

    Methods: We studied 357 patients with retinal disorders including epiretinal membrane (ERM), macular hole (MH), cystoid macular edema with branch / central retinal vein occlusion (BRVO-CME / CRVO-CME), diabetic macular edema (DME), macula-off rhegmatogenous retinal detachment (M-off RD), and macula-on RD (M-on RD) as well as 31 normal controls. The amount of aniseikonia was measured using the New Aniseikonia Test preoperatively and at 6 months postoperatively. Read More

    Optical Coherence Tomography Angiography Analysis of the Foveal Avascular Zone and Macular Vessel Density After Anti-VEGF Therapy in Eyes With Diabetic Macular Edema and Retinal Vein Occlusion.
    Invest Ophthalmol Vis Sci 2017 Jan;58(1):30-34
    Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 4Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States 5Greater Los Angeles VA Healthcare Center, Los Angeles, California, United States.
    Purpose: To evaluate the changes in foveal avascular zone (FAZ) area and the retinal capillary density after a single intravitreal anti-VEGF injection for macular edema secondary to diabetic retinopathy or retinal vein occlusion.

    Methods: In this prospective noncomparative case series, 18 eyes of 15 patients with diabetic macular edema (13 eyes) or macular edema secondary to central retinal vein occlusion (5 eyes) were included. Optical coherence tomography angiography (OCTA) images were obtained, and retinal capillary vessel density and FAZ area were measured in the foveal and parafoveal regions at the level of the superficial (SCP) and deep retinal capillary plexus (DCP) before and at the first visit after intravitreal injection. Read More

    Co-Evaluation of Peripapillary RNFL Thickness and Retinal Thickness in Patients with Diabetic Macular Edema: RNFL Misinterpretation and Its Adjustment.
    PLoS One 2017 23;12(1):e0170341. Epub 2017 Jan 23.
    Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, South Korea.
    We investigated the relationship between the peripapillary retinal nerve fiber layer and peripapillary retinal thickness in patients with diabetic macular edema. Fifty eyes (group I) with non-proliferative diabetic retinopathy and diabetic macular edema receiving intravitreal anti-VEGF injection, and 90 eyes (group II) without diabetic macular edema were included in this case-control study. The peripapillary retinal nerve fiber layer thickness, peripapillary retinal thickness, and a new retinal nerve fiber layer index using a modeled relationship between the two parameters were evaluated with spectral-domain optical coherence tomography, at baseline and at the 6-month follow-up. Read More

    Cardiovascular involvement in patients with diabetic macular oedema treated with intravitreal ranibizumab in routine clinical practice.
    Arch Soc Esp Oftalmol 2017 Jan 19. Epub 2017 Jan 19.
    Unidad de Mácula, Servicio de Oftalmología, Hospital Universitario y Politécnico La Fe, Valencia, España; RETICS RD160008 Enfermedades oculares. Prevención, detección precoz, tratamiento y rehabilitación de las patologías oculares, , Valencia, España.
    Objective: To determine the cardiovascular events in naïve patients with diabetic macular oedema, before and after being treated with intravitreal ranibizumab.

    Material And Methods: A retrospective and descriptive study was conducted on patients with diabetic macular oedema and foveal involvement, who started treatment with intravitreal ranibizumab in 2014 in the Hospital Universitario Nuestra Señora de Candelaria and the Hospital Universitario y Politécnico La Fe. During the follow-up until August 2015, a record was made of parameters, including the prevalence and incidence of stroke and myocardial infarction. Read More

    The incidence and risk factors for the development of vitreomacular interface abnormality in diabetic macular edema treated with intravitreal injection of anti-VEGF.
    Eye (Lond) 2017 Jan 20. Epub 2017 Jan 20.
    Department of Ophthalmology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
    PurposeTo report the incidence and associated factors for the development of vitreomacular interface abnormality (VMIA) in patients with diabetic macular edema (DME) who received intravitreal injection (IVI) of anti-VEGF (Bevacizumab and Ranibizumab) treatment.MethodsA retrospective observational study. Patients with DME followed at least 6 months were reviewed. Read More

    SYSTEMIC PHARMACOKINETICS AND PHARMACODYNAMICS OF INTRAVITREAL AFLIBERCEPT, BEVACIZUMAB, AND RANIBIZUMAB.
    Retina 2017 Jan 18. Epub 2017 Jan 18.
    *California Retina Consultants, Santa Barbara, California; and †Genentech, Inc, South San Francisco, California.
    Purpose: To evaluate the systemic pharmacokinetics (PKs) of aflibercept, bevacizumab, and ranibizumab in patients with neovascular age-related macular degeneration (AMD), diabetic macular edema (DME), or retinal vein occlusion (RVO).

    Methods: Prospective, open-label, nonrandomized clinical trial of patients with AMD, DME, or RVO who were antivascular endothelial growth factor (VEGF) naïve or had not received anti-VEGF for ≥4 months. Patients received 3 monthly intravitreal injections of aflibercept 2. Read More

    Caffeine Prevents Blood Retinal Barrier Damage in a Model, In Vitro, of Diabetic Macular Edema.
    J Cell Biochem 2017 Jan 20. Epub 2017 Jan 20.
    Section of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
    Diabetic macular edema (DME) is the major cause of vision loss in patients affected by diabetic retinopathy. Hyperglycemia and hypoxia, represent the key elements in the progression of this pathologies, leading to breakdown of the blood-retinal barrier (BRB). Caffeine, a psychoactive substance largely consumed in the world, is a nonselective antagonist of adenosine receptors (AR) and it possesses a protective effect in various diseases, including eye pathologies. Read More

    Peri-operative topical non-steroidal anti-inflammatory drugs for macular edema prophylaxis following cataract surgery.
    Am J Ophthalmol 2017 Jan 16. Epub 2017 Jan 16.
    Department of Ophthalmology, Southern California Permanente Medical Group, Baldwin Park, CA; Department of Research and Evaluation, Southern California Permanente Medical Group, Pasadena, CA.
    Purpose: To describe the effect of routine use of topical non-steroidal anti-inflammatory drugs (NSAIDs) on the incidence of post-operative macular edema (PME) after cataract surgery. The role of diabetic retinopathy on the relationship between NSAID use and PME was further analyzed.

    Design: Retrospective matched cohort study. Read More

    INTEGRITY OF OUTER RETINAL LAYERS AFTER RESOLUTION OF CENTRAL INVOLVED DIABETIC MACULAR EDEMA.
    Retina 2017 Jan 13. Epub 2017 Jan 13.
    *Department of Ophthalmology, Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, California; †Department of Ophthalmology, Istanbul Training and Research Hospital, Istanbul, Turkey; and ‡Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California.
    Purpose: To evaluate the integrity of outer retina layers after resolution of central involved diabetic macular edema (DME) and to demonstrate the effect of various baseline factors for the final vision and final external limiting membrane (ELM) integrity.

    Methods: Fifty-nine eyes of 48 patients with resolved DME were included. Several optical coherence tomography parameters including central subfield thickness, maximum foveal thickness, foveal center point thickness, and the extent of the ellipsoidal (ISe) layer and ELM damage were assessed at the time of DME and after resolution of DME. Read More

    Refractive aim and visual outcome after phacoemulsification: A 2-year review from a Tertiary Private Eye Hospital in Sub-Saharan Africa.
    Niger J Clin Pract 2017 Feb;20(2):147-152
    Anterior Segment and Cataract Unit, Eye Foundation Hospital, Lagos, Nigeria.
    Aim: To review the short-term visual outcome of phacoemulsification in adults with uncomplicated cataracts in Eye Foundation Hospital, Lagos, Nigeria.

    Materials And Methods: A retrospective review of records of patients that had phacoemulsification between January 2012 and December 2013 in Eye Foundation Hospital, Lagos, Nigeria, was done. Preoperative visual acuity, refractive aim, intraoperative complications, postoperative unaided, and best-corrected visual acuity at 1 and 3 months were analyzed. Read More

    Elevated Levels of Plasma IgA Autoantibodies against Oxidized LDL Found in Proliferative Diabetic Retinopathy but Not in Nonproliferative Retinopathy.
    J Diabetes Res 2016 20;2016:2614153. Epub 2016 Dec 20.
    PEDEGO Research Unit, Department of Ophthalmology, Medical Research Center (MRC Oulu), Oulu University Hospital and University of Oulu, Oulu, Finland; Research Unit of Internal Medicine, Medical Research Center Oulu (MRC Oulu), Oulu University Hospital and University of Oulu, Oulu, Finland.
    Aims. This study investigated the association of autoantibodies binding to oxidized low-density lipoproteins (oxLDL) in diabetic retinopathy (DR). Methods. Read More

    Efficacy of 0.2 μg/day fluocinolone acetonide implant (ILUVIEN) in eyes with diabetic macular edema and prior vitrectomy.
    Eye (Lond) 2017 Jan 13. Epub 2017 Jan 13.
    Department of Ophthalmology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany.
    PurposeLimited data are available on the efficacy of the 0.2 μg/day fluocinolone acetonide (FAc) implant in eyes with prior vitrectomy. Here, we present a collection of 26 vitrectomized eyes treated with the 0. Read More

    Long-term Effects of Intravitreal 0.19 mg Fluocinolone Acetonide Implant on Progression and Regression of Diabetic Retinopathy.
    Ophthalmology 2017 Jan 9. Epub 2017 Jan 9.
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.
    Objective: To investigate the effects of fluocinolone acetonide (FAc) on the progression to proliferative diabetic retinopathy (PDR) and the impact of FAc on changes in Early Treatment Diabetic Retinopathy Study (ETDRS) diabetic retinopathy (DR) severity scale (DRSS) grade during the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) A and B Phase III clinical trials.

    Design: Post hoc analysis of data from the 36-month prospective, randomized, FAME A and B trials.

    Participants: Patients with diabetic macular edema (DME) who received sham control or FAc 0. Read More

    Influence of the epiretinal membrane on ranibizumab therapy outcomes in patients with diabetic macular edema.
    Arq Bras Oftalmol 2016 Nov-Dec;79(6):373-375
    Ophthalmology Department, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
    Purpose:: To investigate the influence of the epiretinal membrane (ERM) on intravitreal ranibizumab (IVR) therapy for diabetic macular edema (DME).

    Methods:: This retrospective study included 56 eyes of 48 patients with DME divided into two groups: the DME with ERM (study) and only DME (control) groups. Changes in the central macular thickness (CMT) and best-corrected visual acuity (BCVA) were evaluated. Read More

    The Prevention and Treatment of Retinal Complications in Diabetes.
    Dtsch Arztebl Int 2016 Dec;113(48):816-823
    German Agency for Quality in Medicine (ÄZQ), Berlin.
    Background: Microvascular complications of diabetes mellitus can cause retino pathy and maculopathy, which can irreversibly damage vision and lead to blindness. The prevalence of retinopathy is 9-16% in patients with type 2 diabetes and 24-27% in patients with type 1 diabetes. 0. Read More

    Adaptive Optics Reveals Photoreceptor Abnormalities in Diabetic Macular Ischemia.
    PLoS One 2017 9;12(1):e0169926. Epub 2017 Jan 9.
    Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
    Diabetic macular ischemia (DMI) is a phenotype of diabetic retinopathy (DR) associated with chronic hypoxia of retinal tissue. The goal of this prospective observational study was to report evidence of photoreceptor abnormalities using adaptive optics scanning laser ophthalmoscopy (AOSLO) in eyes with DR in the setting of deep capillary plexus (DCP) non-perfusion. Eleven eyes from 11 patients (6 women, age 31-68), diagnosed with DR without macular edema, underwent optical coherence tomography angiography (OCTA) and AOSLO imaging. Read More

    Skin autofluorescence, renal insufficiency and retinopathy in patients with type 2 diabetes.
    J Diabetes Complications 2016 Oct 30. Epub 2016 Oct 30.
    CHU de Bordeaux, Department of Nutrition-Diabetology, Bordeaux, F-33000, France; Univ. Bordeaux, ISPED, F-33000 Bordeaux, France; Inserm, U1219 - Bordeaux Population Health Research Center, F-33000 Bordeaux, France.
    Objectives: Advanced glycation end-products (AGEs) are involved in diabetic retinopathy (DR). Their accumulation in tissues can be analyzed by measuring the skin autofluorescence (sAF). We hypothesized that renal insufficiency, another cause of high sAF, may disturb the relation between sAF and DR. Read More

    Association of statin use and hypertriglyceridemia with diabetic macular edema in patients with type 2 diabetes and diabetic retinopathy.
    Cardiovasc Diabetol 2017 Jan 7;16(1). Epub 2017 Jan 7.
    Department of Ophthalmology, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
    Background: To investigate the effects of dyslipidemia and statin therapy on progression of diabetic retinopathy and diabetic macular edema in patients with type 2 diabetes.

    Methods: The medical records of 110 patients with type 2 diabetes (70 statin users and 40 non-users) were retrospectively reviewed. The two outcome measures were progression of diabetic retinopathy by two or more steps on the early treatment diabetic retinopathy study scale and diabetic macular edema based on optical coherence tomography. Read More

    Evidence-Based Treatment of Diabetic Macular Edema.
    Semin Ophthalmol 2017 ;32(1):56-66
    a Beetham Eye Institute, Joslin Diabetes Center , Boston , MA , USA.
    Diabetes mellitus is a chronic disease that affects 415 million people worldwide. Despite treatment advances, diabetic eye disease remains a leading cause of vision loss worldwide. Diabetic macular edema (DME) is a common cause of vision loss in diabetic patients. Read More

    Machine learning based detection of age-related macular degeneration (AMD) and diabetic macular edema (DME) from optical coherence tomography (OCT) images.
    Biomed Opt Express 2016 Dec 3;7(12):4928-4940. Epub 2016 Nov 3.
    College of Computer Science and Technology, Jilin University, Changchun, Jilin 130012, China; Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Jilin 130012, China; http://www.healthinformaticslab.org/ffzhou/.
    Non-lethal macular diseases greatly impact patients' life quality, and will cause vision loss at the late stages. Visual inspection of the optical coherence tomography (OCT) images by the experienced clinicians is the main diagnosis technique. We proposed a computer-aided diagnosis (CAD) model to discriminate age-related macular degeneration (AMD), diabetic macular edema (DME) and healthy macula. Read More

    Dexamethasone intravitreal implant at the time of cataract surgery in eyes with diabetic macular edema.
    Eur J Ophthalmol 2016 Dec 16. Epub 2016 Dec 16.
    Ophthalmology Unit, Bussolengo Hospital, Bussolengo (Verona) - Italy.
    Purpose: To determine the potential role of intraoperative dexamethasone intravitreal implant (DEX-I) in reducing diabetic macular edema (DME) worsening after phacoemulsification.

    Methods: This was a prospective study on 19 eyes of 19 patients with type 2 diabetes mellitus with DME and cataract. Mean preoperative Early Treatment Diabetic Retinopathy Study visual acuity (VA) was 16. Read More

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