4,304 results match your criteria Macrosomia


Childhood health and education outcomes following early term induction for large-for-gestational age: a population-based record linkage study.

Acta Obstet Gynecol Scand 2018 Dec 4. Epub 2018 Dec 4.

Clinical and Population Perinatal Health Research, Kolling Institute, Northern Sydney Local Health District, Sydney, NSW, Australia.

Introduction: There is debate about optimal management of pregnancies with a large-for-gestational age baby. A recent randomized controlled trial reported that early term induction of labor reduced cesarean section rates and infant morbidity. However, long term childhood outcomes have not been assessed. Read More

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December 2018
1 Read

Early Pregnancy Hemoglobin A1C and Pregnancy Outcomes: A Population-Based Study.

Am J Perinatol 2018 Nov 30. Epub 2018 Nov 30.

Kaiser Permanente Washington Health Research Institute, Seattle, Washington.

Objectives:  Women with prediabetes are identified from screening for overt diabetes in early pregnancy, but the clinical significance of prediabetes in pregnancy is unclear. We examined whether prediabetes in early pregnancy was associated with risks of adverse outcomes.

Study Design:  We conducted a retrospective cohort study of pregnant women enrolled in Kaiser Permanente Washington from 2011 to 2014. Read More

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November 2018
1 Read

Hypoglycaemia on an oral glucose tolerance test in pregnancy - is it clinically significant?

Diabetes Res Clin Pract 2018 Nov 27. Epub 2018 Nov 27.

Diabetes and Endocrine Service, Liverpool Hospital, South Western Sydney Local Health District, NSW Australia.

Aim: During pregnancy, some women have a low glucose level on the 75g oral glucose tolerance test (OGTT). The implications of this are unclear and there is no guideline on how to manage these women.

Method: We recruited pregnant women with a glucose level <3. Read More

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November 2018

Postpartum hemorrhage: incidence, risk factors, and causes in Western French Guiana.

J Gynecol Obstet Hum Reprod 2018 Nov 23. Epub 2018 Nov 23.

Department of Public Health, Centre Hospitalier de l'Ouest Guyanais, Saint-Laurent du Maroni, French Guiana; INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et Santé Publique, Department of Social Epidemiology, Paris, France.

Introduction: Postpartum hemorrhage remains the leading cause of maternal death in France. Parturients in western French Guiana have specific sociodemographic features and a high rate of pathological pregnancies. The objective of this study was to determine the incidence of immediate postpartum hemorrhage (IPPH) in western French Guiana, and to describe the etiologies and risk factors. Read More

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November 2018
6 Reads

Gestational Diabetes: Glycemic Control in the Last Two Weeks Before Delivery Contributes to Newborn Insulinemia.

J Obstet Gynaecol Can 2018 Nov;40(11):1445-1452

Department of Obstetrics & Gynecology, College of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction: Fetal hyperinsulinemia in gestational diabetes mellitus (GDM) not only is important during intrauterine life, a time when it can result in macrosomia, but also at delivery, since it can result in neonatal hypoglycemia and hyperbilirubinemia. The question is, how long before delivery does maternal glycemic control contribute to newborn insulinemia in GDM?

Methods: In 72 women with GDM, we calculated Spearman's rank (r) correlations between umbilical cord blood C-peptide at birth (a biomarker of insulin secretion), and both maternal glycosylated hemoglobin (HbA1c) and mean blood glucose (MBG) recorded in the last two visits prior to delivery. Iterative correlations were done between umbilical cord blood C-peptide at birth, and maternal glucose control, at 0, 1, 2, 3, 4, and 5 weeks before delivery. Read More

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November 2018
1 Read

Physical activity in pregnancy and offspring weight: what we know and what we don't.

BJOG 2018 Nov 20. Epub 2018 Nov 20.

Centre for Big Data Research in Health, UNSW Medicine, Sydney, NSW, Australia.

In this issue of the journal a remote federated individual level meta-analysis evaluates the association between maternal exercise during pregnancy and infant birth weight (BJOG xxxx). The findings are interesting since the authors conclude that physical activity in late, but not early, pregnancy is consistently associated with modestly lower risk of large-for-gestational-age (LGA) and macrosomia, but not small-for-gestational-age (SGA). As with any study though, it is important to understand that the generalizability of the results is determined by the type of population analysed. Read More

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November 2018
1 Read

Addressing knowledge gaps in long term outcomes following embryo freezing.

BJOG 2018 Nov 20. Epub 2018 Nov 20.

Robinson Research Institute, The University of Adelaide, SA, 5005.

Cryopreservation of embryos following in vitro fertilisation (IVF) has been a major advance in assisted reproductive technology (ART), facilitating single embryo transfer and thereby reducing multiple births. Compared with fresh embryo cycles, cryopreservation is also associated with improved pregnancy rates and reductions in preterm birth, small for gestational age and low birth weight (Maheshwari et al Hum Reprod Update 2018;24(1):35-58). However, emerging adverse health impacts include increased risks of hypertensive disease in pregnancy and macrosomia (Maheshwari et al Hum Reprod Update 2018;24(1):35-58). Read More

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November 2018

Metformin-treated-GDM has lower risk of macrosomia compared to diet-treated GDM- A retrospective cohort study.

J Matern Fetal Neonatal Med 2018 Nov 20:1-141. Epub 2018 Nov 20.

a Endocrine Department , Qatar Metabolic Institute , Hamad Medical Corporation , Qatar.

Background: The diagnosis of gestational diabetes (GDM) has undergone several revisions. The broad adoption of the 2013 WHO criteria for hyperglycaemia in pregnancy has increased the prevalence of GDM with no apparent benefit on pregnancy outcomes. The study aims to investigate the pregnancy outcomes in women with GDM diagnosed based on the WHO criteria compared to a control group; the impact of other confounders; and the difference in outcomes between GDM women who needed pharmacotherapy (GDM-T) and those who did not (GDM-D) Methods: This is a retrospective cohort study that included GDM women compared to normoglycaemic controls between March 2015-December 2016 in the Women's Hospital, Qatar. Read More

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November 2018
4 Reads

Adverse neonatal outcomes in overweight and obese adolescents compared with normal weight adolescents and low risk adults.

J Pediatr Adolesc Gynecol 2018 Nov 16. Epub 2018 Nov 16.

Department of Obstetrics and Gynecology, and Department of Clinical and Experimental Medicine, Linköping University, SE-58183 Linköping, Sweden. Electronic address:

Study Objective: To evaluate the association between maternal body mass index and neonatal outcomes in adolescents and to compare neonatal outcomes between overweight and obese adolescents and obstetric low-risk adult women.

Design: Retrospective cohort study using data from the Swedish Medical Birth Register.

Setting: Sweden PARTICIPANTS: All 31,386 primiparous adolescents <20 years and 178,844 standard women, defined as normal weight, obstetric low-risk adult women delivered between 1992-2013. Read More

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November 2018
3 Reads

Comparison of Birth Outcomes by Gestational Diabetes Screening Criteria.

AJP Rep 2018 Oct 29;8(4):e280-e288. Epub 2018 Oct 29.

Department of Epidemiology and Psychiatry, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.

 This study is to examine the association between different diagnostic criteria for gestational diabetes mellitus (GDM) and adverse birth outcomes.  A retrospective cohort study of 5,937 women with a singleton pregnancy was conducted, who completed GDM screening between 24 to 32 weeks gestational age. Four nonoverlapping groups of women defined as: 1) Normal: glucose challenge test (GCT) <130 mg/dL, 2) elevated GCT + normal oral glucose tolerance test (OGTT): abnormal 1 hour GCT + normal 3 hour OGTT, 3) GDM/International Association of Diabetes in Pregnancy Study Group (IADPSG): abnormal 3 hour OGTT by the IADPSG criteria, and 4) GDM/Carpenter-Coustan (CC): diagnosis per CC criteria. Read More

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October 2018
2 Reads

Pregnancy in women with diabetic nephropathy.

Authors:
Donatella Spotti

J Nephrol 2018 Nov 15. Epub 2018 Nov 15.

OU Nephrology and Dialysis, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.

The number of pregnancies in women with pregestational diabetes has been steadily increasing worldwide. These pregnancies are associated with an increased risk of a variety of complications, including miscarriages, congenital malformations, macrosomia, fetal growth restriction, preeclampsia, preterm delivery and stillbirth. In pregnant women with diabetic nephropathy it is important to evaluate both the effect of pregnancy on kidney function and the effect of kidney disease on pregnancy outcomes. Read More

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November 2018
2 Reads

Diabetes in Pregnancy and MicroRNAs: Promises and Limitations in Their Clinical Application.

Noncoding RNA 2018 Nov 12;4(4). Epub 2018 Nov 12.

Endocrinology and Nutrition Department, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.

Maternal diabetes is associated with an increased risk of complications for the mother and her offspring. The latter have an increased risk of foetal macrosomia, hypoglycaemia, respiratory distress syndrome, preterm delivery, malformations and mortality but also of life-long development of obesity and diabetes. Epigenetics have been proposed as an explanation for this long-term risk, and microRNAs (miRNAs) may play a role, both in short- and long-term outcomes. Read More

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November 2018
5 Reads

Elevated microRNA-141-3p in placenta of non-diabetic macrosomia regulate trophoblast proliferation.

EBioMedicine 2018 Nov 9. Epub 2018 Nov 9.

State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China; National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA. Electronic address:

Background: Several studies have reported microRNAs (miRNAs) could regulate the placental development, though the role and mechanism of miRNAs in the development of non-diabetic macrosomia (NDFMS) remains unclear.

Methods: To identify the aberrantly expressed key miRNAs in placenta of NDFMS, we employed a strategy consisting of initial screening with miRNA microarray and further validation with quantitative RT-PCR assay (qRT-PCR). In vitro cellular model and a mouse pregnancy model were used to delineate the functional effects of key miRNA on proliferation, invasion, and migration. Read More

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November 2018
3 Reads

Relationship between the IADPSG-criteria-defined abnormal glucose values and adverse pregnancy outcomes among women having gestational diabetes mellitus: A retrospective cohort study.

Medicine (Baltimore) 2018 Oct;97(43):e12920

Key Laboratory of Birth Defects and Related Diseases of Women and Children, (Sichuan University), Ministry of Education.

To explore the influence of the 75 g oral glucose tolerance test (OGTT) on pregnancy outcomes and to determine the risk factors for adverse outcomes among women with gestational diabetes mellitus (GDM).This retrospective cohort study was conducted among women who had GDM and were treated between January 1, 2015 and December 31, 2017. The diagnostic criteria for GDM were proposed by the International Diabetes and Pregnancy Research Organization (IADPSG) in 2010. Read More

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October 2018
4 Reads

Attenuation of maternal weight gain impacts infant birthweight: systematic review and meta-analysis.

J Dev Orig Health Dis 2018 Nov 9:1-19. Epub 2018 Nov 9.

1Department of Nutrition and Dietetics, Faculty of Medicine,Nursing and Health Sciences,School of Clinical Sciences,Monash University,Clayton,VIC,Australia.

Despite many interventions aiming to reduce excessive gestational weight gain (GWG), it is currently unclear the impact on infant anthropometric outcomes. The aim of this review was to evaluate offspring anthropometric outcomes in studies designed to reduce GWG. A systematic search of seven international databases, one clinical trial registry and three Chinese databases was conducted without date limits. Read More

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November 2018
3 Reads

Maternal demographic and intrapartum antecedents of severe neonatal outcomes at term.

J Matern Fetal Neonatal Med 2018 Nov 8:1-6. Epub 2018 Nov 8.

a Faculty of Medicine, The University of Queensland , Brisbane , Australia.

Objective: To determine key demographic and intrapartum antecedents predisposing to severe adverse neonatal outcome at term.

Methods: This was a retrospective cohort study of severe adverse neonatal outcomes of nonanomalous singleton term births at an Australian tertiary maternity unit between January 2007 and April 2017. Serious neonatal outcome (SNO) was defined as any of the following: Apgar score ≤3 at 5 min, severe respiratory distress syndrome, severe acidosis, admission into neonatal intensive care unit (NICU), stillbirth, or neonatal death. Read More

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November 2018
5 Reads

Medical nutrition therapy for gestational diabetes mellitus based on Mediterranean Diet principles: a subanalysis of the St Carlos GDM Prevention Study.

BMJ Open Diabetes Res Care 2018 11;6(1):e000550. Epub 2018 Oct 11.

Endocrinology and Nutrition Department, Hospital Clínico San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.

Objectives: To assess whether Mediterranean Diet (MedDiet)-based medical nutrition therapy facilitates near-normoglycemia in women with gestational diabetes mellitus (GDMw) and observe the effects on adverse pregnancy outcomes.

Research Design And Methods: This is a secondary analysis of the St Carlos GDM Prevention Study, conducted between January and December 2015 in Hospital Clínico San Carlos (Madrid, Spain). One thousand consecutive women with normoglycemia were included before 12 gestational weeks (GWs), with 874 included in the final analysis. Read More

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October 2018
5 Reads

Stillbirth and large for gestational age at birth.

J Matern Fetal Neonatal Med 2018 Nov 4:1-6. Epub 2018 Nov 4.

a Partnership for Research and Education in Mothers and Infants. Department of Obstetrics and Gynecology and Community Health Sciences , Cummings School of Medicine University of Calgary , Alberta , Canada.

Aim: A previous large case-control study had documented association between large for gestational age birth weight and stillbirth. We sought to replicate this novel finding.

Methods: Retrospective cohort with nested case-control analyses. Read More

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November 2018
3 Reads

[Association between maternal tea consumption in pregnancy and birth outcomes].

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Oct;52(10):1013-1017

Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

The purpose of this study was to explore the relationship between maternal tea consumption and birth outcomes. From January 2005 to December 2010, pregnant women were recruited from Nanjing Maternity and Child Health Hospital. The basic information and the situation of tea consumption during pregnancy were investigated using questionnaire and the birth outcomes of newborns were followed up. Read More

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October 2018
7 Reads

Increased placental IGF-1/mTOR activity in macrosomia born to women with gestational diabetes.

Diabetes Res Clin Pract 2018 Oct 31;146:211-219. Epub 2018 Oct 31.

Medical Biology Laboratory of the Experimental Teaching Center, Capital Medical University, China.

Aims: Newborns of women with gestational diabetes mellitus (GDM) are susceptible to be macrosomic, even if the blood glucose levels are in normal ranges. The underlying mechanisms are largely unknown. We tested the hypothesis that placental insulin like growth factor(IGF)-I and mammalian target of rapamycin (mTOR) signaling is activated and amino acid transporter expression is increased in women with GDM who give birth to macrosomic babies. Read More

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October 2018

[Definition, epidemiology and risk factors of obstetric anal sphincter injuries: CNGOF Perineal Prevention and Protection in Obstetrics Guidelines].

Gynecol Obstet Fertil Senol 2018 Oct 29. Epub 2018 Oct 29.

Service de gynécologie-obstétrique, hôpitaux de Nantes, CHU Hôtel-Dieu, 38, boulevard Jean-Monnet, 44000 Nantes, France; Université de Nantes, 1, rue Gaston-Veil, 44000 Nantes, France.

Objectives: The aim of this review was to agree on a definition of the obstetric anal sphincter injuries (OASIS), to determine the prevalence and risk factors.

Methods: A comprehensive review of the literature on the obstetric anal sphincter injuries (OASIS), establishment of levels of evidence (NP), and grades of recommendation according to the methodology of the recommendations for clinical practice.

Results: To classify obstetric anal sphincter injuries (OASIS), we have used the WHO-RCOG classification, which lists 4 degrees of severity. Read More

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October 2018
5 Reads

Single prior caesarean section and risk of anal sphincter injury.

Int Urogynecol J 2018 Oct 30. Epub 2018 Oct 30.

Department of Obstetrics and Gynaecology, Our Lady of Lourdes Hospital, Drogheda, Co. Louth, Ireland.

Introduction And Hypothesis: Injury to the anal sphincter at vaginal delivery remains the leading cause of faecal incontinence in women. Previous studies reported an increased incidence of obstetric anal sphincter injury (OASI) in women attempting vaginal birth after caesarean section (VBAC). The aim of the paper was to establish whether women in their second pregnancy, with one previous uterine scar, are at a higher risk of OASI compared with nulliparous women. Read More

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October 2018
1 Read

Perinatal outcomes of women undergoing cesarean delivery after prior myomectomy.

J Matern Fetal Neonatal Med 2018 Nov 20:1-6. Epub 2018 Nov 20.

a Divison of Maternal Fetal Medicine, Department of Obstetrics and Gynecology , The George Washington University School of Medicine and Health Sciences , Washington , District of Columbia , USA.

Background: The American College of Obstetricians and Gynecologists recommends that women who have had a prior myomectomy that entered the endometrial cavity undergo cesarean delivery in order to avoid the possible complication of uterine rupture. Women with prior myomectomies may also have intraabdominal adhesions, complicating future surgery and if myomas remain after myomectomy, they may have more bleeding complications during their subsequent pregnancies.

Objectives: The purpose of this study was to evaluate maternal and neonatal outcomes after prior myomectomy in women undergoing planned cesarean delivery. Read More

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November 2018
6 Reads

Birth population survey in Huai'an in 2015: perinatal-neonatal mortality and preterm birth rate in emerging regions in China.

J Matern Fetal Neonatal Med 2018 Oct 29:1-9. Epub 2018 Oct 29.

j Departments of Pediatrics and Obstetrics , Jinhu County Hospital , Huai'an , China.

Objective: This survey followed the birth population-based study conducted in 2010 in Huai'an, Jiangsu Province, with the aim to estimate perinatal-neonatal mortality and preterm birth rate in emerging regions with similar maternal-fetal and neonatal care conditions in China.

Materials And Methods: Data of total births in 2015 were prospectively collected by regional perinatal network collaboration in Huai'an, a subprovincial region with a population of 5,644,500 and gross domestic production of 9082 USD per capita.

Results: The 59,424 birth registries (including 59,023 live births and 167 stillbirths) corresponded to a birth rate of 10. Read More

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October 2018
4 Reads

The Pathophysiology of Gestational Diabetes Mellitus.

Int J Mol Sci 2018 Oct 26;19(11). Epub 2018 Oct 26.

Liggins Institute, University of Auckland, Auckland 1023, New Zealand.

Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In most cases, this hyperglycemia is the result of impaired glucose tolerance due to pancreatic β-cell dysfunction on a background of chronic insulin resistance. Risk factors for GDM include overweight and obesity, advanced maternal age, and a family history or any form of diabetes. Read More

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October 2018
4 Reads

Association between Gestational Weight Gain, Gestational Diabetes Risk, and Obstetric Outcomes: A Randomized Controlled Trial Post Hoc Analysis.

Nutrients 2018 Oct 23;10(11). Epub 2018 Oct 23.

Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Van der Boechorststraat 7, NL-1081 BT Amsterdam, The Netherlands..

Excess gestational weight gain (GWG) is associated with the development of gestational diabetes mellitus (GDM). Lifestyle trials have not achieved much GWG limitation, and have largely failed to prevent GDM. We compared the effect of substantial GWG limitation on maternal GDM risk. Read More

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October 2018
4 Reads
3.150 Impact Factor

Racial and Ethnic Patterning of Low Birth Weight, Normal Birth Weight, and Macrosomia.

Prev Med 2018 Oct 18;118:196-204. Epub 2018 Oct 18.

Department of Sociology, University of California, Irvine, United States of America.

Both low birthweight (<2500 g; LBW) and macrosomia (>4000 g) are considered adverse birth outcomes and are associated with later poor health conditions, yet the social determinants of macrosomia are understudied. In this study, we explore patterning of LBW, normal birthweight, and macrosomia by race/ethnicity and nativity. We examined data from all live births between 1999 and 2014 in New Jersey with a non-missing, plausible value of birthweight (n = 1,609,516). Read More

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October 2018
3 Reads

Impact of prenatal exercise on neonatal and childhood outcomes: a systematic review and meta-analysis.

Br J Sports Med 2018 Nov;52(21):1386-1396

R Samuel McLaughlin Foundation - Exercise and Pregnancy Laboratory, School of Kinesiology, Faculty of Health Sciences, Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Children's Health Research Institute, The University of Western Ontario, London, Ontario, Canada.

Objective: We aimed to identify the relationship between maternal prenatal exercise and birth complications, and neonatal and childhood morphometric, metabolic and developmental outcomes.

Design: Systematic review with random-effects meta-analysis and meta-regression.

Data Sources: Online databases were searched up to 6 January 2017. Read More

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November 2018
1 Read

The impact of isolated maternal hypothyroxinemia during the first and second trimester of gestation on pregnancy outcomes: an intervention and prospective cohort study in China.

J Endocrinol Invest 2018 Oct 17. Epub 2018 Oct 17.

Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People's Republic of China.

Objectives: To explore the effect of isolated maternal hypothyroxinemia (IMH) during the first and second trimester of gestation on pregnancy outcomes. To explore whether levothyroxine (L-T4) treatment of women who had IMH identified in the first trimester improves pregnancy outcomes.

Methods: Women in the early pregnancy in the iodine-sufficient area (n = 3398) were recruited to this prospective cohort study (ChiCTR-TRC-12002326). Read More

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October 2018
2 Reads

Sonographic prediction of macrosomia in pregnancies complicated by maternal diabetes: finding the best formula.

Arch Gynecol Obstet 2018 Oct 16. Epub 2018 Oct 16.

Hillel Yaffe Medical Center, Hadera, Israel.

Purpose: To evaluate the best performing formula for macrosomia prediction in pregnancies complicated by diabetes.

Methods: A retrospective analysis was performed of 1060 sonographic fetal biometrical measurements performed within 7 days of delivery in term pregnancies (37-42 gestational weeks) complicated by diabetes. Sonographic prediction of macrosomia (≥ 4000, ≥ 4250, and ≥ 4500 g) was evaluated utilizing ten previously published formulas by: (1) calculating for each macrosomia threshold the sensitivity, specificity, positive and negative predictive value, and ± likelihood ratio for macrosomia prediction; (2) comparing the systematic and random error and the proportion of estimates < 10% of birth weights between macrosomic and non-macrosomic neonates. Read More

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October 2018
3 Reads

The efficacy of omega-3 fatty acid for gestational diabetes: a meta-analysis of randomized controlled trials.

Gynecol Endocrinol 2018 Oct 16:1-6. Epub 2018 Oct 16.

a Orthopaedics Dept.4 , No. 2 Hospital of Ningbo , Zhejiang , China.

Introduction: The efficacy of omega-3 fatty acid to treat gestational diabetes remains controversial. We conduct a systematic review and meta-analysis to explore the influence of omega-3 fatty acid versus placebo on gestational diabetes.

Methods: We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through March 2018 for randomized controlled trials (RCTs) assessing the effect of omega-3 fatty acid versus placebo on gestational diabetes. Read More

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October 2018
5 Reads

Development of an integrated, district-wide approach to pre-pregnancy management for women with pre-existing diabetes in a multi-ethnic population.

BMC Pregnancy Childbirth 2018 Oct 15;18(1):402. Epub 2018 Oct 15.

Western Sydney University, Sydney, NSW, 2751, Australia.

Background: Poor diabetes management prior to conception, results in increased rates of fetal malformations and other adverse pregnancy outcomes. We describe the development of an integrated, pre-pregnancy management strategy to improve pregnancy outcomes among women of reproductive age with diabetes in a multi-ethnic district.

Methods: The strategy included (i) a narrative literature review of contraception and pre-pregnancy interventions for women with diabetes and development of a draft plan; (ii) a chart review of pregnancy outcomes (e. Read More

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October 2018
3 Reads

Obesity and Weight Gain in Pregnancy and Postpartum: an Evidence Review of Lifestyle Interventions to Inform Maternal and Child Health Policies.

Front Endocrinol (Lausanne) 2018 26;9:546. Epub 2018 Sep 26.

London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom.

Maternal obesity, excessive gestational weight gain (GWG) and post-partum weight retention (PPWR) constitute new public health challenges, due to the association with negative short- and long-term maternal and neonatal outcomes. The aim of this evidence review was to identify effective lifestyle interventions to manage weight and improve maternal and infant outcomes during pregnancy and postpartum. A review of systematic reviews and meta-analyses investigating the effects of lifestyle interventions on GWG or PPWR was conducted (Jan 2009-2018) via electronic searches in the databases Medline, Pubmed, Web of Science and Cochrane Library using all keywords related to obesity/weight gain/loss, pregnancy or postpartum and lifestyle interventions;15 relevant reviews were selected. Read More

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September 2018
2 Reads

Obesity alters the uterine environment before pregnancy.

J Nutr Biochem 2018 Dec 19;62:181-191. Epub 2018 Sep 19.

Universidad de Buenos Aires (UBA), Facultad de Ciencias Exactas y Naturales (FCEN), Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA-Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Buenos Aires, Argentina; UBA, FCEN, Departamento de Biodiversidad y Bilogía Experimental, Buenos Aires, Argentina. Electronic address:

Obesity is a metabolic disorder that predisposes to numerous diseases and has become a major global public health concern. Cafeteria diet (CAF) is the animal model used for the study of obesity that more closely reflects Western diet habits. Previously, we described that CAF administration for 60 days induces obesity in female rats and their fetuses develop macrosomia. Read More

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December 2018
6 Reads

Gestational diabetes and macrosomia among Greenlanders. Time to change diagnostic strategy?

Int J Circumpolar Health 2018 12;77(1):1528126

b Greenland Center of Health Research, Institute of Nursing and Health Science , University of Greenland , Nuuk , Greenland.

Gestational diabetes mellitus (GDM) is a serious condition associated to both maternal and offspring complications. Yet, no globally accepted consensus exists on how to test and diagnose GDM. In Greenland, the clinical criteria for testing and diagnosing GDM are adapted from Danish guidelines. Read More

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December 2018
3 Reads

The Association between Maternal Height, Body Mass Index, and Perinatal Outcomes.

Am J Perinatol 2018 Oct 6. Epub 2018 Oct 6.

Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon.

Objective:  To test the hypothesis that maternal height is associated with adverse perinatal outcomes, controlling for and stratified by maternal body mass index (BMI).

Study Design:  This was a retrospective cohort study of all births in California between 2007 and 2010 ( = 1,775,984). Maternal height was categorized into quintiles, with lowest quintile (≤20%) representing shorter stature and the uppermost quintile (≥80%) representing taller stature. Read More

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October 2018
7 Reads

Prepregnancy obesity status and risks on pregnancy outcomes in Shanghai: A prospective cohort study.

Medicine (Baltimore) 2018 Oct;97(40):e12670

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Obesity in women of reproductive age is not only associated with numerous adverse maternal and fetal effects prenatally but also exerts a negative influence on female fertility. The aim of this study was to investigate the situation of prepregnant obesity in Shanghai and explore the impact of prepregnant obesity on gestational weight gain as well as other pregnancy outcomes. A prospective hospital-based pregnant women cohort was established in Shanghai since January 2015. Read More

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October 2018
3 Reads

Prenatal profile of Pallister-Killian syndrome: Retrospective analysis of 114 pregnancies, literature review and approach to prenatal diagnosis.

Am J Med Genet A 2018 Oct 5. Epub 2018 Oct 5.

Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Pallister-Killian syndrome (PKS) is a tissue limited mosaic disorder, characterized by variable degrees of neurodevelopmental delay and intellectual disability, typical craniofacial findings, skin pigmentation anomalies and multiple congenital malformations. The wide phenotypic spectrum of PKS in conjunction with the mosaic distribution of the i(12p) makes PKS an underdiagnosed disorder. Recognition of prenatal findings that should raise a suspicion of PKS is complicated by the fragmentation of data currently available in the literature and challenges in diagnosing a mosaic diagnosis on prenatal testing. Read More

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October 2018
11 Reads

Birth Weight and Risk of Childhood Acute Lymphoblastic Leukemia in Arizona, Illinois, and Kentucky.

South Med J 2018 Oct;111(10):579-584

From the Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, Kentucky, Department of Epidemiology, College of Public Health, University of Kentucky, Lexington, the Illinois State Cancer Registry, Springfield, and the Arizona Cancer Registry, Phoenix.

Objective: To confirm the previously reported increased risk of leukemia among macrosomic children (those with birth weight >4 kg).

Methods: Birth certificates of Arizona, Illinois, and Kentucky children diagnosed as having acute lymphoblastic leukemia (ALL) before age 5 years were matched with birth certificates from leukemia-free children of the same sex, race, and ethnicity who were born in the same county on or about the same day. Odds ratios (ORs) for ALL among children of low (<2. Read More

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October 2018
8 Reads

Disadvantages of a weight estimation formula for macrosomic fetuses: the Hart formula from a clinical perspective.

Arch Gynecol Obstet 2018 Dec 4;298(6):1101-1106. Epub 2018 Oct 4.

Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler University Hospital, Johannes Kepler University, Altenberger Straße 69, 4040, Linz, Austria.

Purpose: Sonographic fetal weight (FW) estimation to detect macrosomic fetuses is an essential part of everyday routine work in obstetrics departments. Most of the commonly used weight estimation formulas underestimate FW when the actual birth weight (BW) exceeds 4000 g. One of the best-established weight estimation formulas is the Hadlock formula. Read More

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December 2018
3 Reads

Induction of labor versus expectant management among women with macrosomic neonates. A retrospective study.

J Matern Fetal Neonatal Med 2018 Oct 1:1-251. Epub 2018 Oct 1.

a Department of Obstetrics and Gynecology , Bnai-Zion Medical Center , Israel Affiliated to the Ruth and Bruce Rappaport Faculty of Medicine , Technion - Israel Institute of Technology , Haifa , Haifa , Israel.

Background: The macrosomic fetus predisposes a variety of adverse maternal and perinatal outcomes. Although older studies have shown no benefit in inducing women of suspected macrosomic fetuses, more updated studies show different information.

Objectives: The aim of our study was to compare induction of labor versus expectant management among women with macrosomic neonates weighing more than 4000 g at term (between 37 and 41 weeks' gestation). Read More

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October 2018
3 Reads

Relationship between 50-g glucose challenge test and large for gestational age infants among pregnant women without gestational diabetes.

J Obstet Gynaecol 2018 Sep 27:1-6. Epub 2018 Sep 27.

a Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital , Mahidol University , Bangkok , Thailand.

The study aimed to compare the incidence of large for gestational age (LGA) infants between women with a false positive and normal glucose challenge test (GCT), and to evaluate the factors associated with LGA. A total of 480 pregnant women at risk for gestational diabetes mellitus (GDM); 160 with a false positive GCT and 320 with normal GCT results were included. The incidence of LGA and other pregnancy outcomes were compared between the two groups. Read More

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September 2018
2 Reads

Transient Isolated Polyhydramnios and Perinatal Outcomes.

Ultraschall Med 2018 Sep 25. Epub 2018 Sep 25.

Lis Maternity and Women's Hospital, Tel-Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Purpose:  To evaluate labor and perinatal outcomes of transient isolated polyhydramnios.

Materials And Methods:  A retrospective cohort study (2008 - 2013) at a university-affiliated, tertiary medical center. Eligibility was limited to patients with singleton gestations, no maternal diabetes or known structural/chromosomal anomalies, and no rupture of the membranes prior to delivery, at > 34 weeks of gestation. Read More

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September 2018
12 Reads

Small-for-pregnancy-age rats submitted to exercise: DNA damage in mothers and newborns, measured by the comet assay.

Mutat Res 2018 Nov 18;835:11-15. Epub 2018 Aug 18.

Postgraduate Course on Gynecology, Obstetrics and Mastology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University - UNESP, Botucatu, São Paulo State, Brazil. Electronic address:

Background: Fetal impairment caused by a deleterious intrauterine environment may have long-term consequences, such as oxidative stress and genetic damage. Rats born as small-for-gestational-age (SPA) were submitted to exercise (swimming) before and during pregnancy. The animals exhibited glucose intolerance, reduced general adiposity, and increased maternal and offspring organ weight, showing the benefit of exercise for these rats. Read More

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November 2018
5 Reads

Early screening and treatment of gestational diabetes in high-risk women improves maternal and neonatal outcomes: A retrospective clinical audit.

Diabetes Res Clin Pract 2018 Oct 21;144:294-301. Epub 2018 Sep 21.

Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK; Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK; University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. Electronic address:

Aims: Evidence suggests that screening for gestational diabetes (GDM) occurs too late in pregnancy, when changes in glucose metabolism and fetal growth rates can already be detected. In August 2016 NHS Lothian began screening women with risk factors for GDM during early pregnancy (11-13 weeks). We hypothesised that an earlier identification and treatment of dysglycaemia would improve pregnancy outcomes compared to previous standard care. Read More

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October 2018
2 Reads

Effects of physical exercise during pregnancy on maternal and infant outcomes in overweight and obese pregnant women: A meta-analysis.

Birth 2018 Sep 21. Epub 2018 Sep 21.

School of Health Sciences, Wuhan University, Wuhan, China.

Background: Overweight and obesity are related to maternal and infant physical health, such as gestational diabetes, preeclampsia, and macrosomia. The purpose of this meta-analysis was to assess the effect of physical exercise on maternal and infant outcomes in overweight and obese pregnant women.

Methods: Two researchers independently searched Cochrane Library, Embase, PubMed, Web of Science, and ClinicalTrials. Read More

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September 2018
1 Read
2.050 Impact Factor

Untargeted metabolomics: an overview of its usefulness and future potential in prenatal diagnosis.

Expert Rev Proteomics 2018 Oct 4;15(10):809-816. Epub 2018 Oct 4.

d Centre for Metabolomics and Bioanalysis (CEMBIO), Facultad de Farmacia , Universidad CEU San Pablo , Madrid , Spain.

Introduction: Metabolomics opens up new avenues for biomarker discovery in different branches of medicine, including perinatology. Chromosomal aberration, preterm delivery (PTD), congenital heart defects, spina bifida, chorioamnionitis, and low birth weight are the main perinatal pathologies. Investigations using untargeted metabolomics have found the candidate metabolites for diagnostic biomarkers. Read More

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October 2018
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Novel de novo pathogenic variant in the ODC1 gene in a girl with developmental delay, alopecia, and dysmorphic features.

Am J Med Genet A 2018 Sep 21. Epub 2018 Sep 21.

Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, Michigan.

The ornithine decarboxylase 1 (ODC1) gene plays an important role in physiological and cell developmental processes including embryogenesis, organogenesis, and neoplastic cell growth. Here, we report an 32-month-old Caucasian female with a heterozygous de novo nonsense mutation in the ODC1 gene that leads to a premature abrogation of 14-aa residues at the ODC protein c-terminus. This is the first human case confirming similar symptoms observed in a transgenic ODC1 mouse model first described over 20 years ago. Read More

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September 2018
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[Multiple birth trends in the region of Castilla y León (Spain) in a 13 year period].

An Pediatr (Barc) 2018 Sep 17. Epub 2018 Sep 17.

Servicio de Pediatría, Complejo Asistencial Universitario de Palencia (CAUPA), Palencia, España.

Introduction: Multiple pregnancy has increased in prevalence in the last few years, which could lead to more foetal and maternal morbidity issues. The aim of this study is to describe the trend of multiple pregnancy deliveries in Castilla y León during the last 13years and the subsequent impact on foetal and maternal health.

Material And Methods: Data was collected from the hospital discharge reports registered in the Regional Health-care database (SACYL: Health care in Castilla y León) between 2001 and 2013. Read More

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September 2018
1 Read