5,546 results match your criteria Macrosomia


Weight gain rate in the second and third trimesters and fetal growth in women with gestational diabetes mellitus: a retrospective cohort study.

BMC Pregnancy Childbirth 2022 May 20;22(1):424. Epub 2022 May 20.

Department of Clinical Nutrition, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.

Background: Controversial evidence regarding the applicability of the IOM's gestational weight gain (GWG) targets for women with gestational diabetes mellitus (GDM) has been reported. However, little is known about the weight gain rate (WGR) during the second and third trimesters. Moreover, previous studies failed to assess the effect modification of pre-pregnancy BMI because of the limited sample size. Read More

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Live births of immigrant mothers in Brazil: A population-based study.

J Migr Health 2022 20;5:100108. Epub 2022 Apr 20.

Department of Epidemiology, School of Public Health, University of São Paulo - FSP / USP Brazil.

Introduction: Migration has become a major challenge for many countries, and women constitute half of the migrants in the world. Few studies have been conducted on migrant mothers in Brazil. We aim to identify differences in the pregnancies, childbirths, and live birth (LB) indicators of immigrant women, compared with those of Brazilian women living in the municipality of São Paulo (MSP), Brazil. Read More

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Is limited access to obstetric services associated with adverse birth outcomes? A cross-sectional study of Korean national birth data.

BMJ Open 2022 May 19;12(5):e056634. Epub 2022 May 19.

Preventive Medicine, Korea University-Anam Campus, Seongbuk-gu, Seoul, Korea

Objectives: The geographical disparity in the access to essential obstetric services is a public health issue in many countries. We explored the association between timely access to obstetric services and the individual risk of adverse birth outcomes.

Design: Repeated cross-sectional design. Read More

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Molecular communication between Apelin-13, Apelin-36, Elabela, and nitric oxide in gestational diabetes mellitus.

Eur Rev Med Pharmacol Sci 2022 May;26(9):3289-3300

Department of Endocrinology and Metabolic Diseases, Department of Cardiovascular Surgery (Anatomy), Fethi Sekin City Hospital, Elazig, Turkey.

Objective: Gestational diabetes mellitus (GDM) is a type of diabetes that affects from 3.8% to 6.9% of pregnancies worldwide, causing significant mortality and unfavorable obstetric outcomes, such as delivery trauma and macrosomia risk. Read More

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Evaluation of obstetric management of women with macrosomic foetuses in two Level 3 maternity hospitals in France and identification of predictive factors for obstetric and neonatal complications.

Eur J Obstet Gynecol Reprod Biol 2022 Apr 13;274:34-39. Epub 2022 Apr 13.

CHU REIMS Maison Blanche, 45 Rue Cognacq Jay 51100 Reims, France.

Objective: Foetal macrosomia is associated with high maternal and neonatal morbidity; however, obstetric management of suspected macrosomia has not been well defined. This study aimed to analyse obstetric management in a population of women who delivered macrosomic new-borns and assess maternal and neonatal outcomes and risk factors for complications in such cases.

Study Design: This two-centre retrospective study conducted in France over a 10-year period comprised 1724 women who had delivered macrosomic new-borns (defined as those whose weight was > 90th percentile according to the Association of Users of Computerised Records in Perinatology, Obstetrics, and Gynaecology curve) from 37SA. Read More

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Accuracy of Fetal Biacromial Diameter and Derived Ultrasonographic Parameters to Predict Shoulder Dystocia: A Prospective Observational Study.

Int J Environ Res Public Health 2022 May 9;19(9). Epub 2022 May 9.

Obstetrics and Gynecology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80128 Naples, Italy.

Background And Objectives: Shoulder dystocia (ShD) is one of most dangerous obstetric complication. The objective of this study was to determine if the ultrasonographic fetal biacromial diameter (BA) and derived parameters could predict ShD in uncomplicated term pregnancies.

Materials And Methods: We conducted a prospective observational study in a tertiary care university hospital from March 2021 to February 2022. Read More

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Investigation and Application of Risk Factors of Macrosomia Based on 10,396 Chinese Pregnant Women.

Front Endocrinol (Lausanne) 2022 26;13:837816. Epub 2022 Apr 26.

Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, China.

Objective: The objective of this study was to examine the association of fetal macrosomia with maternal D-dimer and blood lipid levels, and explore whether D-dimer and blood lipids, either alone or in combination with traditional risk factors at hospital birth, could be used to predict subsequent delivery of macrosomia.

Methods: From April 2016 to March 2017, 10,396 women with singleton pregnancy giving birth at around 28-41 weeks of gestation were recruited into the present study. D-dimer and blood lipid levels were measured at hospital admission; and data on birth outcomes were obtained from hospital records. Read More

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Obstetric and perinatal outcomes following programmed compared to natural frozen-thawed embryo transfer cycles: a systematic review and meta-analysis.

Hum Reprod 2022 May 13. Epub 2022 May 13.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy.

Study Question: Is there an association between the different endometrial preparation protocols for frozen embryo transfer (FET) and obstetric and perinatal outcomes?

Summary Answer: Programmed FET protocols were associated with a significantly higher risk of hypertensive disorders of pregnancy (HDP), pre-eclampsia (PE), post-partum hemorrhage (PPH) and cesarean section (CS) when compared with natural FET protocols.

What Is Known Already: An important and growing source of concern regarding the use of FET on a wide spectrum of women, is represented by its association with obstetric and perinatal complications. However, reasons behind these increased risks are still unknown and understudied. Read More

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Exosomal RNA Expression Profiles and Their Prediction Performance in Patients With Gestational Diabetes Mellitus and Macrosomia.

Front Endocrinol (Lausanne) 2022 25;13:864971. Epub 2022 Apr 25.

Nanjing Maternity and Child Health Care Institute, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.

Introduction: Exosomes are cell-derived vesicles that are present in many biological fluids. Exosomal RNAs in cord blood may allow intercellular communication between mother and fetus. We aimed to establish exosomal RNA expression profiles in cord blood from patients with gestational diabetes mellitus and macrosomia (GDM-M) and evaluate their prediction performance. Read More

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Correction to: Response to Comment on "Gestational body weight gain and risk of low birth weight or macrosomia in women of Japan: a nationwide cohort study".

Int J Obes (Lond) 2022 May 11. Epub 2022 May 11.

University of Yamanashi Hospital, Diabetes and Endocrinology, 1110, Shimokato, Chuo-shi, Yamanashi, 409-3898, Japan.

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Addition of intermittently scanned continuous glucose monitoring to standard care in a cohort of pregnant women with type 1 diabetes: effect on glycaemic control and pregnancy outcomes.

Diabetologia 2022 May 12. Epub 2022 May 12.

Diabetes Unit, Endocrinology Department, Hospital Clínic de Barcelona, Barcelona, Spain.

Aims/hypothesis: The aim of this study was to assess whether the addition of intermittently scanned continuous glucose monitoring (isCGM) to standard care (self-monitoring of blood glucose [SMBG] alone) improves glycaemic control and pregnancy outcomes in women with type 1 diabetes and multiple daily injections.

Methods: This was a multicentre observational cohort study of 300 pregnant women with type 1 diabetes in Spain, including 168 women using SMBG (standard care) and 132 women using isCGM in addition to standard care. In addition to HbA, the time in range (TIR), time below range (TBR) and time above range (TAR) with regard to the pregnancy glucose target range (3. Read More

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Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice.

J Physiol 2022 May 11. Epub 2022 May 11.

Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Obesity in pregnant women causes fetal cardiac dysfunction and increases offspring cardiovascular disease risk, but its effect on myocardial metabolism is unknown. We hypothesized that maternal obesity alters fetal cardiac expression of metabolism-related genes and shifts offspring myocardial substrate preference from glucose towards lipids. Female mice were fed control or obesogenic diets before and during pregnancy. Read More

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Pregnancy outcomes at advanced maternal age in a tertiary Hospital, Jeddah, Saudi Arabia.

Saudi Med J 2022 May;43(5):491-499

From the Department of Obstetrics and Gynecology, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.

Objectives: To evaluate obstetrical and fetal outcomes among advanced maternal age (AMA) women.

Methods: Retrospective cohort study carried out at a teaching hospital, Jeddah, Saudi Arabia, during 18 years period (from January 2003 until December 2020). A total of 79095 women gave birth, and randomized block was used to include 4318 singleton pregnancy women (>28 gestational weeks), of them 2162 age ≥40 years. Read More

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Impact of earlier gestational diabetes screening for pregnant people with obesity on maternal and perinatal outcomes.

J Perinat Med 2022 May 11. Epub 2022 May 11.

Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA.

Objectives: Gestational diabetes (GDM) screening at 24-28 weeks' gestation reduces risk of adverse maternal and perinatal outcomes. While experts recommend first-trimester screening for high-risk patients, including those with obesity, data supporting this recommendation is limited.

Methods: We implemented a systematic population intervention to encourage first-trimester GDM screening by oral glucose tolerance testing in a cohort of pregnant people with obesity in two integrated health systems from 2009 to 2013, and compared outcomes to the same population pre-intervention (2006-2009). Read More

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Effects of metformin on pregnancy outcome, metabolic profile, and sex hormone levels in women with polycystic ovary syndrome and their offspring: a systematic review and meta-analysis.

Ann Transl Med 2022 Apr;10(7):418

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.

Background: Researches of the efficacy and safety of metformin on long-term pregnancy outcomes remains conflicted. We performed an updated systematic review and meta-analysis to systematically investigate the effect of metformin treatment on pregnancy outcome, metabolic profile, and sex hormone characteristics in women with polycystic ovary syndrome (PCOS) and their offspring.

Methods: The PubMed, Embase, and Cochrane Library databases were searched from inception to July 10, 2021 with the keywords "metformin", "PCOS", and "pregnancy". Read More

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An Investigation of the Relationship Between Dietary Patterns in Early Pregnancy and Maternal/Infant Health Outcomes in a Chinese Cohort.

Front Nutr 2022 22;9:775557. Epub 2022 Apr 22.

College of Life Sciences, University of Leicester, Leicester, United Kingdom.

Background: Studies assessing links between maternal diet and pregnancy outcomes have focused predominantly on individual nutrients or foods. However, nutrients are typically consumed in combinations of foods or beverages (i.e. Read More

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Effect of Levothyroxine on Pregnancy Outcomes in Pregnant Women With Hypothyroxinemia: An Interventional Study.

Front Endocrinol (Lausanne) 2022 19;13:874975. Epub 2022 Apr 19.

Department of Obstetrics, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Context: Adverse maternal outcomes and perinatal complications are associated with maternal hypothyroidism. However, the utility of levothyroxine (L-T4) in the treatment of pregnant women with hypothyroxinemia is unclear.

Objective: This study aimed to evaluate the effects of L-T4 on maternal and perinatal outcomes in pregnant women with hypothyroxinemia. Read More

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Nomogram-based risk prediction of macrosomia: a case-control study.

BMC Pregnancy Childbirth 2022 May 5;22(1):392. Epub 2022 May 5.

Department of Endocrinology and metabolism, Peking University International Hospital, No. 1 Life Garden Road Zhongguancun Life Science Garden Changping District, Beijing, 102206, China.

Background: Macrosomia is closely associated with poor maternal and fetal outcome. But there is short of studies on the risk of macrosomia in early pregnancy. The purpose of this study is to establish a nomogram for predicting macrosomia in the first trimester. Read More

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Adverse obstetric and perinatal outcomes in 2333 singleton pregnancies conceived after different endometrial preparation protocols: a retrospective study in China.

BMC Pregnancy Childbirth 2022 May 1;22(1):378. Epub 2022 May 1.

Tianjin Central Hospital of Gynecology Obstetrics/Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, 300100, China.

Backgroup: Frozen-thawed embryo transfer is rising worldwide. One adverse effect of programmed frozen embryo transfer (FET) reported in some studies is an increased risk of adverse obstetric and perinatal outcomes. Meanwhile, body mass index (BMI) also has adverse effect on obstetric and perinatal outcomes. Read More

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Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study.

Front Endocrinol (Lausanne) 2022 14;13:853473. Epub 2022 Apr 14.

Reproductive Medical Center, Henan Provincial People's Hospital, Zhengzhou, China.

Objective: The objective of the study was to explore the effect of insulin resistance on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) from the first embryo transfer cycle.

Design: This was a single-center, retrospective, observational cohort study.

Patients: Included in the study were women with PCOS for the first embryo transfer. Read More

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Evolution of maternal and neonatal outcomes before and after the adoption of the IADPSG/WHO guidelines in Belgium: A descriptive study of 444,228 pregnancies.

Heliyon 2022 Apr 12;8(4):e09251. Epub 2022 Apr 12.

Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Liège, site CHR Citadelle, Boulevard du 12ème de Ligne, 1, 4000 Liège, Belgium.

Objectives: To appraise adverse pregnancy outcomes after the adoption of IADPSG/WHO guidelines in Belgium.

Methods: A retrospective study of the Center for Perinatal Epidemiology registry was conducted. Demographic changes and adverse pregnancy outcomes were compared between a pre- and post-guideline period in women with and without hyperglycemia in pregnancy (HIP). Read More

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Effect of Pre-pregnancy Maternal Body Mass Index on Obstetric Outcomes in a Tertiary Care Hospital in Goa, India.

J Obstet Gynaecol India 2022 Apr 23;72(2):141-146. Epub 2021 Sep 23.

Department of Obstetrics and Gynaecology, Goa Medical College, Bambolim, Goa India.

Introduction: Maternal body mass index (BMI) is a vital predictor of the nutritional status of any pregnant woman. Several developing countries like India are facing the double burden of both obesity and malnutrition due the extreme socioeconomic distribution of our population. Thus, this study was undertaken to study the effect of pre-pregnancy maternal BMI on the obstetric outcomes. Read More

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Association between Maternal Birth Weight and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.

J Obstet Gynaecol India 2022 Apr 7;72(2):125-133. Epub 2022 Apr 7.

Student Research Committee, Department of Epidemiology, Kerman University of Medical Sciences, Kerman, Iran.

Background And Aims: Gestational diabetes mellitus is one of the most important issue related to health status of mothers and their children throughout life. This meta-analysis has been conducted to assess relationship between maternal birth weight and gestational diabetes.

Methods And Results: This article is written using PRISMA guideline for systematic review and meta-analysis. Read More

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Diagnostic Accuracy of Diabetes in Pregnancy Study Group of India with Carpenter-Coustan and National Diabetes Data Group Criteria for Diagnosis of Gestational Diabetes Mellitus and Correlation with Fetomaternal Outcome.

J Obstet Gynaecol India 2022 Apr 22;72(2):154-159. Epub 2021 Jun 22.

Department of Biochemistry, Lady Hardinge Medical College and SSKH, New Delhi, India.

Background: No previous study compared ACOG and DIPSI criteria for diagnosing gestational diabetes (GDM). This study compared diagnostic accuracy of Diabetes in pregnancy study group of India (DIPSI) with Carpenter-Coustan (CC) and National Diabetes Data Group (NDDG) criteria for diagnosis of GDM and correlation with fetomaternal outcome.

Methods: A total of 1029 pregnant women underwent 2 h 75 g OGTT in non-fasting state. Read More

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Early life programming of nonalcoholic fatty liver disease in children.

Early Hum Dev 2022 May 26;168:105578. Epub 2022 Apr 26.

University of Montreal Hospital Research Centre, 900 Saint-Denis St, Montreal, Quebec H2X 0A9, Canada; Institut national de santé publique du Québec, 190 Cremazie Blvd E, Montreal, Quebec H2P 1E2, Canada; Department of Social and Preventive Medicine, School of Public Health, University of Montreal, 7101 Park Avenue, Montreal, Quebec H3N 1X9, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, 1020 Pine Ave W, Montreal, Quebec H3A 1A2, Canada. Electronic address:

Background: Research is beginning to implicate early life characteristics in the development of pediatric nonalcoholic fatty liver disease, however the relationship with perinatal characteristics is poorly understood.

Aims: We evaluated the association between perinatal characteristics and nonalcoholic fatty liver disease in childhood.

Study Design: Nested case-control study. Read More

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Associations of Gestational Diabetes Mellitus and Excessive Gestational Weight Gain with Offspring Obesity Risk.

Curr Med Sci 2022 Apr 29. Epub 2022 Apr 29.

Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Objective: Gestational diabetes mellitus (GDM) and gestational weight gain (GWG) are important risk factors that are known to affect offspring growth, but these outcomes are inconsistent and it remains unknown if both risk factors have a synergetic effect on early childhood growth. The present study aimed to conduct offspring body mass index-for-age Z-scores (BMIZ) trajectories and to evaluate the independent and interactive effect of the status of GDM and excessive GWG on the risks of overweight/obesity from birth to 24 months of age.

Methods: A total of 7949 mother-child pairs were enrolled in this study. Read More

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A prenatal case of Simpson-Golabi-Behmel syndrome type 1 with a 0.26-Mb deletion fragment at Xq26.2 inherited from mother: Case report.

Medicine (Baltimore) 2022 Apr 22;101(16):e29222. Epub 2022 Apr 22.

Xuzhou Central Hospital, Xuzhou Clinical Schools of Xuzhou Medical University and Nanjing Medical University, Xuzhou, Jiangsu, China.

Rationale: The purpose of this report was to explore how to manage the fetus of Simpson-Golabi-Behmel syndrome type 1 (SGBS1) and to provide a definite diagnosis to guide the following genetic counseling for the pregnancy.

Patient Concerns: A 24-year-old women, gravida 1, para 0, was 172 cm tall with weight 65 kg. She was referred to our center for counseling due to second-trimester ultrasound screening anomalies at 22 + 5 weeks of gestation age. Read More

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Prevalence and factors associated to gestational diabetes mellitus among pregnant women in Libreville: a cross-sectional study.

Pan Afr Med J 2022 15;41:129. Epub 2022 Feb 15.

Department of Chemistry and Biochemistry, Faculty of Medicine, University of the Health Sciences, Libreville, Gabon.

Introduction: mainly occurring in low and middle income countries, gestational diabetes mellitus (GDM) represents 84% of hyperglycemia during pregnancy throughout the world. Moreover, being black is a risk factor to develop the disease. Our objective was to determine the prevalence and the associated factors of GDM in Libreville (Gabon). Read More

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Association between Body Mass Index and Gestational Weight Gain with Obstetric and Neonatal Complications in Pregnant Women with Gestational Diabetes.

Acta Med Port 2022 Apr 26. Epub 2022 Apr 26.

Internal Medicine Department. Centro Hospitalar de Póvoa de Varzim/Vila do Conde. Póvoa de Varzim. Portugal.

Introduction: Gestational diabetes is a condition that predisposes to complications during pregnancy and to the newborn. The aim of this study was to assess the association between body mass index and gestational weight gain and obstetric and neonatal complications in pregnant women with gestational diabetes.

Material And Methods: Retrospective cohort study involving 13 467 singleton pregnancies with gestational diabetes, diagnosed between 2014 and 2018, in Portugal. Read More

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Induction of labour at 39 weeks versus expectant management in low-risk obese women: study protocol for a randomised controlled study.

BMJ Open 2022 Apr 25;12(4):e057688. Epub 2022 Apr 25.

Department of Obstetrics and Gynaecology, Aarhus University Hospital, Aarhus N, Denmark.

Introduction: Obesity is associated with many pregnancy complications, including both fetal macrosomia and prolonged labour. As a result, there is often also an increased risk of caesarean section. In other settings, labour induction near to term reduces adverse outcomes such as stillbirth and birth injury, without causing more caesarean deliveries. Read More

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