4,793 results match your criteria Macrosomia


Gestational diabetes mellitus increased the risk of adverse neonatal outcomes: A prospective cohort study in Northwest Ethiopia.

Midwifery 2020 May 19;87:102713. Epub 2020 May 19.

Department of Epidemiology and Biostatistics, Institute of Public Health, University of Gondar, Gondar, Ethiopia. Electronic address:

Background: Gestational diabetes mellitus is a rising global public health problem that can have short- and long-term sequelae for both mother and offspring. However, there are limited evidences on the effect of gestational diabetes mellitus on adverse neonatal outcomes using the updated international diagnostic criteria on adverse effects on neonatal outcomes. Therefore, this study was aimed to examine the effects of gestational diabetes mellitus on the risk of adverse neonatal outcomes in Ethiopia. Read More

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http://dx.doi.org/10.1016/j.midw.2020.102713DOI Listing

Comparative impact of pharmacological treatments for gestational diabetes on neonatal anthropometry independent of maternal glycaemic control: A systematic review and meta-analysis.

PLoS Med 2020 May 22;17(5):e1003126. Epub 2020 May 22.

Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.

Background: Fetal growth in gestational diabetes mellitus (GDM) is directly linked to maternal glycaemic control; however, this relationship may be altered by oral anti-hyperglycaemic agents. Unlike insulin, such drugs cross the placenta and may thus have independent effects on fetal or placental tissues. We investigated the association between GDM treatment and fetal, neonatal, and childhood growth. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003126DOI Listing

Are there specific factors associated with prenatally undiagnosed foetal macrosomia?

J Gynecol Obstet Hum Reprod 2020 May 10:101802. Epub 2020 May 10.

Port-Royal Maternity Unit, Department of Obstetrics Paris, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Objective: Fetal macrosomia is known to increase maternal and neonatal complications, but 20%-50% of the macrosomic fetuses are prenatally undiagnosed. Our objective was to identify specific factors associated with undiagnosed fetal macrosomia in women without diabetes.

Methods: Retrospective case-control study in a tertiary maternity unit between January 1st and December 31st, 2016. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101802DOI Listing

False diagnosis of small for gestational age and macrosomia - clinical and sonographic predictors.

J Matern Fetal Neonatal Med 2020 May 19:1-7. Epub 2020 May 19.

Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera, Israel.

To investigate clinical and sonographic features associated with sonographic accuracy for the prediction of small for gestational age (SGA) and macrosomia at birth. The database of a tertiary medical center was retrospectively searched for women who gave birth at term to a singleton healthy neonate in 2007-2014 and underwent sonographic estimated fetal weight (sEFW) evaluation within 3 d before delivery. Fetal growth restriction (FGR) and SGA were defined as sEFW or birth weight <10th percentile for gestational age; macrosomia was defined as birth weight >4000 grams. Read More

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http://dx.doi.org/10.1080/14767058.2020.1762559DOI Listing

Two criteria of oral glucose tolerance test to diagnose gestational diabetes mellitus.

Rev Assoc Med Bras (1992) 2020 May;66(2):139-145

. Escola de Medicina. Universidade do Sul de Santa Catarina, Palhoça, SC, Brasil.

Objective: To evaluate two different criteria, one or two cut-off values, of oral glucose tolerance test with 75g of glucose for the diagnosis of gestational diabetes mellitus.

Methods: A cross-sectional study involving 120 records of pregnant women who received prenatal care at the service of a Brazilian university was carried out. Bivariate analysis of obstetric and perinatal outcomes was performed using the chi-square test. Read More

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http://dx.doi.org/10.1590/1806-9282.66.2.139DOI Listing

Early Pregnancy Screening for Women at High-Risk of GDM Results in Reduced Neonatal Morbidity and Similar Maternal Outcomes to Routine Screening.

J Pregnancy 2020 29;2020:9083264. Epub 2020 Jan 29.

Pregnancy Research Centre, Department of Maternal-Fetal Medicine, Royal Women's Hospital, Melbourne, VIC, Australia.

The Australasian Diabetes in Pregnancy Society recommends screening high-risk women for gestational diabetes mellitus (GDM) before 24 weeks gestation, under the assumption that an earlier diagnosis and opportunity to achieve normoglycemia will minimize adverse outcomes. However, little evidence exists for this recommendation. The study objective was to compare the pregnancy outcomes of high-risk women diagnosed with GDM before 24 weeks gestation and routinely diagnosed women after 24 weeks gestation. Read More

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http://dx.doi.org/10.1155/2020/9083264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204101PMC
January 2020

Association between endometrial thickness and neonatal outcomes in intrauterine insemination cycles: a retrospective analysis of 1,016 live-born singletons.

Reprod Biol Endocrinol 2020 May 14;18(1):48. Epub 2020 May 14.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, China.

Background: Decreased endometrial thickness (EMT) has been suggested to be associated with reduced birthweight of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) newborns. Considering the differences in ovarian stimulation degree and laboratory procedures between IVF/ICSI and IUI treatment, we aim to investigate whether EMT has any influence on IUI infant outcomes as well.

Methods: This was a retrospective cohort study of 1016 patients who had singleton livebirths after IUI treatment cycles from January 2008 to December 2018 at a tertiary-care academic medical center in China. Read More

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http://dx.doi.org/10.1186/s12958-020-00597-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222451PMC

Effect of paternal body mass index on neonatal outcomes of singletons after frozen-thawed embryo transfer cycles: analysis of 7,908 singleton newborns.

Fertil Steril 2020 May 10. Epub 2020 May 10.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated with JiaoTong University School of Medicine, Shanghai, People's Republic of China. Electronic address:

Objective: To investigate the effect of paternal body mass index (BMI) on neonatal outcomes of singletons after frozen-thawed embryo transfer (FET) cycles.

Design: Retrospective cohort study.

Setting: Tertiary-care academic medical center. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2020.02.100DOI Listing
May 2020
4.590 Impact Factor

Is there a definite relationship between placental mTOR signaling and fetal growth?

Biol Reprod 2020 May 13. Epub 2020 May 13.

Reproductive Medical Center, Department of Obstetrics and Gynecology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi Province, 710038, China.

Fetal growth restriction and overgrowth are common obstetrical complications that result in adverse perinatal outcomes and long-term health risks later in life, including neurodevelopmental dysfunction and adult metabolic syndrome. Placenta plays a critical role in the nutrition transfer from mother to fetus and even exert adaptive mechanism when the fetus is under poor developmental conditions. The mammalian/mechanistic target of rapamycin (mTOR) signaling serves as a critical hub of cell growth, survival, and metabolism in response to nutrients, growth factors, energy, and stress signals. Read More

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http://dx.doi.org/10.1093/biolre/ioaa070DOI Listing

Taking guidance from parents involved in a longitudinal birth cohort - the ROLO family advisory committee.

Res Involv Engagem 2020 28;6:16. Epub 2020 Apr 28.

UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.

Background: The ROLO Study (Randomised cOntrol trial of a Low glycaemic index diet in pregnancy to prevent macrosomia) was a randomised control trial conducted between 2007 and 2011 to examine if a low glycaemic index (GI) diet could reduce the incidence of macrosomia. The ROLO Family Advisory Committee is a self-selected group of parents who are involved in the longitudinal follow-up of the ROLO Study. The committee was established in 2017 and the goal is to achieve a partnership between ROLO families and researchers, leading to improved research quality, relevance, and outcomes. Read More

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http://dx.doi.org/10.1186/s40900-020-00200-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189585PMC

Ferulic acid confers protection on islet β cells and placental tissues of rats with gestational diabetes mellitus.

Cell Mol Biol (Noisy-le-grand) 2020 Apr 20;66(1):37-41. Epub 2020 Apr 20.

Department of Gynaecology and Obstetrics, Xi'an NO.4 Hospital, Xi'an, PR China.

Gestational diabetes mellitus (GDM) refers to glucose intolerance of variable degree with onset or first recognition during pregnancy. It causes polyhydramnios, ketoacidosis, fetal macrosomia, and neonatal respiratory distress syndrome. The incidence of GDM has greatly increased, hence the search for new interventions that can effectively treat it. Read More

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Identification of newborns with birthweight ≥ 4,500g: Ultrasound within one- vs. two weeks of delivery.

Eur J Obstet Gynecol Reprod Biol 2020 Apr 18;249:47-53. Epub 2020 Apr 18.

Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.

Objective: Our objective was to compare the diagnostic characteristics of sonographic estimated fetal weight (SEFW) done within 7 versus 8-14 days before delivery for detection of fetal macrosomia (birthweight ≥ 4500 g).

Study Design: We performed a multicenter, retrospective cohort study of all non-anomalous singletons with SEFW ≥ 4000 g by Registered Diagnostic Medical Sonographers conducted within 14 days of delivery. Cohorts were grouped by time interval between ultrasound and delivery: 0-7 days versus 8-14 days. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.04.028DOI Listing

Dietary total antioxidant capacity during pregnancy and birth outcomes.

Eur J Nutr 2020 Apr 29. Epub 2020 Apr 29.

Department of Social Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil.

Purpose: To investigate the effect of maternal dietary total antioxidant capacity (DTAC) and main food sources on the risk of preterm birth (PB) and offspring birth size.

Methods: Cohort study that included 733 Brazilian mother-child pairs. Two 24 h dietary recalls were obtained during pregnancy and the usual intake was estimated through the Multiple Source Method. Read More

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http://dx.doi.org/10.1007/s00394-020-02251-yDOI Listing
April 2020
3.467 Impact Factor

Determinants of the persistency of macrosomia and shoulder dystocia despite treatment of gestational diabetes mellitus.

Heliyon 2020 Apr 9;6(4):e03756. Epub 2020 Apr 9.

Department of Obstetrics, Cochin-Port-Royal Hospital, AP-HP, Paris Descartes University, DHU Risks in Pregnancy, 123 boulevard de Port-Royal, 75014, Paris, France.

Aims: to identify potentially modifiable risk factors associated with the persistency of macrosomia and/or shoulder dystocia in infants born to women treated for gestational diabetes mellitus (GDM).

Methods: this case-control retrospective study included 113 cases complicated by macrosomia (ponderal index ≥97 percentile) and/or shoulder dystocia, and 226 controls without these complications. Factors associated with macrosomia and/or shoulder dystocia and with failure of diabetes management were assessed by multivariable analyses. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182725PMC

Neonatal Outcomes of Pregnancy Following Roux-en-Y Gastric Bypass: a Matched Case-Control Study.

Obes Surg 2020 Apr 26. Epub 2020 Apr 26.

Postgraduate Program in Medical Sciences, Endocrinology, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Purpose: To compare perinatal outcomes and to assess the predictors of birth weight (BW) after Roux-en-Y gastric bypass (RYGB) to those women unexposed to bariatric surgery.

Materials And Methods: Singleton births from women submitted to RYGB (BSG) were matched to two control births by maternal age, delivery year, and gender. Control group 1 (CG1) and control group 2 (CG2) were selected according to the prepregnancy body mass index (BMI) < 35 kg/m and ≥ 35 kg/m, respectively, without previous bariatric surgery. Read More

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http://dx.doi.org/10.1007/s11695-020-04633-xDOI Listing

Type II caesarean scar pregnancy management by ultrasound-guided local lauromacrogol injection in combination with suction curettage: A case report.

Medicine (Baltimore) 2020 Apr;99(17):e19743

Center of Reproductive Medicine.

Introduction: The implantation of a gestational sac within the scar of a previous caesarean delivery is defined as caesarean scar pregnancy (CSP), which is classified into two types: CSP I and CSP II. CSP II is life threatening, and no clear consensus for CSP II management exists.

Patient Concerns: A 31-year-old woman, gravida 1, para 1, with a previous caesarean delivery due to macrosomia, presented with an estimated 45 days of amenorrhea. Read More

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http://dx.doi.org/10.1097/MD.0000000000019743DOI Listing

Elevated First-Trimester Neutrophil Count Is Closely Associated with the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes.

Diabetes 2020 Apr 24. Epub 2020 Apr 24.

Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, 801 Heqin Road, Shanghai 200240, China

Chronic low-grade inflammation plays a central role in the pathophysiology of gestational diabetes mellitus (GDM). In order to investigate the ability of different inflammatory blood cell parameters in predicting the development of GDM and pregnancy outcomes, 258 women with GDM and 1154 women without were included in this retrospective study. First-trimester neutrophil count outperformed white blood cell (WBC) count, and neutrophil-to-lymphocyte ratio (NLR) in the predictability for GDM. Read More

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http://dx.doi.org/10.2337/db19-0976DOI Listing
April 2020
8.095 Impact Factor

Gestational weight gain and its effect on birth outcomes in sub-Saharan Africa: Systematic review and meta-analysis.

PLoS One 2020 23;15(4):e0231889. Epub 2020 Apr 23.

Centre for Midwifery, Child and Family Health, Faculty of Health, University of Technology Sydney, Ultimo, NSW, Australia.

Introduction: An increased metabolic demand during pregnancy is fulfilled by gaining sufficient gestational weight. Women who gain inadequate-weight are at a high-risk of premature birth or having a baby with low-birth weight. However, women who gain excessive-weight are at a high-risk of having a baby with macrosomia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231889PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179909PMC
April 2020
3.234 Impact Factor

Increased Risk of Pre-eclampsia After Frozen-Thawed Embryo Transfer in Programming Cycles.

Front Med (Lausanne) 2020 8;7:104. Epub 2020 Apr 8.

Center for Reproductive Medicine, Shandong University, Jinan, China.

This study aims to investigate whether obstetric complications and perinatal outcomes after frozen embryo transfer (FET) in the programming cycles differ from that in the natural cycles. We conducted a retrospective cohort study collecting a total of 14,373 singletons born after frozen embryo transfer at the Center for Reproductive Medicine Affiliated to Shandong University from September 2013 to September 2018. The women were divided into two groups according to the regimens for endometrium preparation: either natural cycles ( = 10,211) or programming cycles ( = 4,162). Read More

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http://dx.doi.org/10.3389/fmed.2020.00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156607PMC

Placental Lactogen as a Marker of Maternal Obesity, Diabetes, and Fetal Growth Abnormalities: Current Knowledge and Clinical Perspectives.

J Clin Med 2020 Apr 16;9(4). Epub 2020 Apr 16.

Division of Reproduction, Department of Obstetrics, Gynecology, and Gynecologic Oncology, Poznań University of Medical Sciences, 33 Polna St, 60-535 Poznan, Poland.

Placental lactogen (PL) is a peptide hormone secreted throughout pregnancy by both animal and human specialized endocrine cells. PL plays an important role in the regulation of insulin secretion in pancreatic β-cells, stimulating their proliferation and promoting the expression of anti-apoptotic proteins. Cases of pregnancy affected by metabolic conditions, including obesity and diabetes, are related to alterations in the PL secretion pattern. Read More

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http://dx.doi.org/10.3390/jcm9041142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230810PMC

Diagnostic value of sonographic fetal anthropometries and anthropometric formulas to identify macrosomia: a meta-analysis.

Authors:
Eita Goto

Minerva Ginecol 2020 Apr 21. Epub 2020 Apr 21.

Department of Medicine and Public Health, Nagoya Medical Science Research Institute, Nagoya, Japan -

Background: This study evaluated whether sonographic fetal anthropometries and anthropometric formulas can identify macrosomia, with increases in mortality and morbidity rates in infanthood and probably later in life.

Evidence Acquisition: Meta-analysis including good-quality studies determined summarized sensitivity, specificity, positive and negative likelihood ratios (PLR and NLR, respectively), and area under the curve (AUC). PLR and NLR divided informational usability into exclusion and confirmation strategies (10 < PLR and NLR < 0. Read More

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http://dx.doi.org/10.23736/S0026-4784.20.04535-9DOI Listing

The impact of male infertility or intracytoplasmic sperm injection technique on perinatal outcomes.

J Matern Fetal Neonatal Med 2020 Apr 15:1-7. Epub 2020 Apr 15.

Reroductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The aim of this study was to evaluate the impact of male infertility or intracytoplasmic sperm injection (ICSI) technique on perinatal outcomes. A retrospective cohort study included patients with singleton live births after fresh-cycle embryo transfer that occurred between 1 January 2016 and 31 May 2018. The patients were divided into four groups: (1) IVF treatment without male infertility; (2) ICSI treatment without male infertility; (3) ICSI treatment with male infertility; and (4) IVF treatment with male infertility. Read More

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http://dx.doi.org/10.1080/14767058.2020.1730802DOI Listing

Predicting Postpartum Hemorrhage After Vaginal Birth by Labor Phenotype.

J Midwifery Womens Health 2020 Apr 14. Epub 2020 Apr 14.

Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia.

Introduction: Postpartum hemorrhage (PPH) is an important contributor to maternal morbidity and mortality. Predicting which laboring women are likely to have a PPH is an active area of research and a component of quality improvement bundles. The purpose of this study was to identify phenotypes of labor processes (ie, labors that have similar features, such as duration and type of interventions) in a cohort of women who had vaginal births, estimate the likelihood of PPH by phenotype, and analyze how maternal and fetal characteristics relate to PPH risk by phenotype. Read More

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http://dx.doi.org/10.1111/jmwh.13104DOI Listing

Incidence of large for gestational age and predictive values of third-trimester ultrasound among pregnant women with false-positive glucose challenge test.

J Obstet Gynaecol 2020 Apr 14:1-5. Epub 2020 Apr 14.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

This cohort study aimed to determine the association between false-positive 50-g GCT and incidence of LGA and to evaluate predictive roles of third-trimester ultrasonographic examination. A total of 200 women with false-positive 50-g GCT and 188 women without GDM risks were enrolled. Third-trimester ultrasonographic examinations were offered. Read More

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http://dx.doi.org/10.1080/01443615.2020.1732890DOI Listing

Obesity, gestational weight gain, and birth weight in women with gestational diabetes: the LINDA-Brasil (2014-2017) and the EBDG (1991-1995) studies.

J Pediatr (Rio J) 2020 Apr 10. Epub 2020 Apr 10.

Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Medicina, Departamento de Medicina Social, Programa de Pós-Graduação em Epidemiologia, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Medicina, Departamento de Nutrição, Programa de Pós-Graduação em Alimentação, Nutrição e Saúde, Porto Alegre, RS, Brazil. Electronic address:

Objective: This study aimed to evaluate gestational weight gain and birth weight in women with gestational diabetes mellitus of two Brazilian cohorts enrolled three decades apart.

Methods: The authors compared data of 2362 women from the Lifestyle INtervention for Diabetes Prevention After Pregnancy study (LINDA-Brasil, 2014-2017) to those of 359 women from the Estudo Brasileiro de Diabetes Gestacional study (EBDG, 1991-1995). Gestational weight gain was classified by the 2009 Institute of Medicine criteria; large and small for gestational age newborns, by the Intergrowth-21 chart. Read More

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http://dx.doi.org/10.1016/j.jped.2020.02.004DOI Listing

A 12-hour comprehensive nutrition care benefits blood glucose level and weight gain and improves outcomes in pregnant women with gestational diabetes mellitus.

Ann Palliat Med 2020 Apr 5. Epub 2020 Apr 5.

Department of Nutrition, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.

Background: Gestational diabetes mellitus (GDM) is associated with adverse outcomes and neonatal complications. Its prevalence has been rapidly increasing over the last decade; it is estimated that one in six pregnant women are diagnosed with GDM. Thus, an effective management approach is necessary for women with GDM. Read More

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http://dx.doi.org/10.21037/apm.2020.03.16DOI Listing

Whole-Genome Promoter Profiling of Plasma DNA Exhibits Diagnostic Value for Placenta-Origin Pregnancy Complications.

Adv Sci (Weinh) 2020 Apr 18;7(7):1901819. Epub 2020 Feb 18.

Institute of Antibody Engineering School of Laboratory Medicine and Biotechnology Southern Medical University Guangzhou 510515 China.

Placenta-origin pregnancy complications, including preeclampsia (PE), gestational diabetes mellitus (GDM), fetal growth restriction (FGR), and macrosomia (MA) are common occurrences in pregnancy, resulting in significant morbidity and mortality for both mother and fetus. However, despite their frequency, there are no reliable methods for the early diagnosis of these complications. Since cfDNA is mainly derived from placental trophoblasts and maternal hematopoietic cells, it might have information for gene expression which can be used for disease prediction. Read More

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http://dx.doi.org/10.1002/advs.201901819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141029PMC

Early Gestational Diabetes Mellitus Screening With Glycated Hemoglobin: A Systematic Review.

J Obstet Gynaecol Can 2020 Apr 5. Epub 2020 Apr 5.

Sioux Lookout Meno Ya Win Health Centre, Sioux Lookout, ON. Electronic address:

Objective: This review sought to examine the association of HbA levels <6.5% in early pregnancy with the subsequent development of gestational diabetes mellitus (GDM) and adverse pregnancy outcomes.

Methods: A search of Medline and EMBASE was conducted for the period of January 1, 2000 to July 9, 2019 and the terms: "gestational diabetes or pregnancy diabetes mellitus" and "glycosylated hemoglobin or glycated hemoglobin A" and "pregnancy trimester, first, or first-trimester pregnancy," "screening or prenatal screening," "prenatal diagnosis or early diagnosis or prediction," "retrospective studies or prospective studies. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.12.015DOI Listing

Risk and adverse outcomes of gestational diabetes in migrants: A population cohort study.

Diabetes Res Clin Pract 2020 Apr 4;163:108128. Epub 2020 Apr 4.

Epidemiology Unit, Regional Health Agency of Tuscany, Florence, Italy.

Aims: To evaluate the risk of gestational diabetes (GDM) and of neonatal/maternal complications (macrosomia, large for gestational age (LGA), cesarean sections, preterm deliveries, neonatal distress and fetal malformations) among women coming from High Migration Pressure Countries (HMPC), compared to native (Italian) mothers.

Methods: Risks of GDM and related neonatal/maternal complications were evaluated in a cohort of 581,073 Italian compared with 105,111 HMPC women of age 15-45 yr, resident in Tuscany, Italy along years 2012-2017, delivering 122,652 singleton live births (18,596 from HMPC mothers).

Results: HMPC women, compared to Italian ones, were at higher risk of GDM (OR: 1. Read More

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http://dx.doi.org/10.1016/j.diabres.2020.108128DOI Listing

Size and Shape of Associations of OGTT as Well as Mediating Effects on Adverse Pregnancy Outcomes Among Women With Gestational Diabetes Mellitus: Population-Based Study From Southern Han Chinese.

Front Endocrinol (Lausanne) 2020 17;11:135. Epub 2020 Mar 17.

Foshan Fetal Medicine Research Institute, Foshan Women and Children Hospital Affiliated to Southern Medical University, Foshan, China.

To explore the size and shape association of OGTT values with adverse pregnancy complications among women with gestational diabetes mellitus (GDM) in Southern Han Chinese population and further analyze their mediating effects with maternal age in outcomes. 6,861 women with GDM were included in the study. Logistic regression was used to identify the correlations between OGTT values and adverse pregnancy outcomes of GDM. Read More

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http://dx.doi.org/10.3389/fendo.2020.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092640PMC

Low volume forceps practice and anal sphincter injury rate.

Arch Gynecol Obstet 2020 May 6;301(5):1133-1138. Epub 2020 Apr 6.

The Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, POB 12000, 91120, Jerusalem, Israel.

Purpose: While the increased rates of high degree perineal tears were previously associated with the use of forceps, in the current era of low volume of forceps practice, factors associated with the occurrence of this potential complication remain understudied. We aim to evaluate factors associated with obstetric anal sphincter injury (OASIS) in obstetric units with a low volume forceps practice.

Methods: A retrospective cohort study was conducted at two tertiary medical centers. Read More

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http://dx.doi.org/10.1007/s00404-020-05519-0DOI Listing

Effectiveness of telemedicine for pregnant women with gestational diabetes mellitus: an updated meta-analysis of 32 randomized controlled trials with trial sequential analysis.

BMC Pregnancy Childbirth 2020 Apr 6;20(1):198. Epub 2020 Apr 6.

Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.

Background: Gestational diabetes mellitus (GDM) is now a global health problem. Poor blood glucose control during pregnancy may lead to maternal and neonatal/foetal complications. Recently, the development of information and communication technology has resulted in new technical support for the clinical care of GDM. Read More

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http://dx.doi.org/10.1186/s12884-020-02892-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137255PMC

Association between rankl [RS9594759] and IL10 [RS1800896] Genes polymorphism and deciduous tooth eruption terms in Ukrainians born macrosomic.

Wiad Lek 2020 ;73(2):342-351

Shupyk National Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine, Kyiv, Ukraine.

Objective: The aim: The article deals with analyzing the influence of polymorphic variants of CYP19A1 [rs2414096, rs936306], ESR1 [rs2234693, rs9340799], IL1 [rs1143627], IL6 [rs1800796], IL10 [rs1800896] and RANKL [rs959389] genes on deciduous tooth eruption terms in individuals born macrosomic.

Patients And Methods: Materials and methods: 171 individuals participated in the multi-stage study (144 macosomic-at-birth individuals and 27 normosomic-at-birth persons). This study included only persons who have preserved information about the timing of deciduous tooth eruption - 159 persons (aged from 4 to 55 years), male and female (male / female ratio was 1. Read More

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Concentrations of fatty acids among macrosomic neonates delivered by healthy women and women with type 1 diabetes mellitus.

Int J Gynaecol Obstet 2020 Jun 27;149(3):309-317. Epub 2020 Apr 27.

Clinical Department of Obstetrics and Gynecology, Zagreb University Hospital Center, School of Medicine, University of Zagreb, Zagreb, Croatia.

Objective: To evaluate the concentration and profile of fatty acids (FAs) among macrosomic neonates delivered by healthy pregnant women and pregnant women with type 1 diabetes mellitus (T1DM).

Methods: A prospective study of women who delivered macrosomic neonates at a University Hospital Center, Zagreb, Croatia, 2016-2018. Maternal, umbilical vein, and arterial blood samples were collected immediately on delivery. Read More

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http://dx.doi.org/10.1002/ijgo.13151DOI Listing

Impact of type I and type II maternal diabetes mellitus on fetal cardiac function assessment parameters using spectral and tissue Doppler.

Int J Cardiovasc Imaging 2020 Mar 31. Epub 2020 Mar 31.

Department of Obstetrics, Paulista School of Medicine - Federal University of São Paulo (EPM- UNIFESP), Rua Belchior de Azevedo, 156 apto. 111 Torre Vitoria, São Paulo, SP, CEP 05089-030, Brazil.

The aim of this study was to evaluate the impact of pregestational diabetes mellitus (DM) on fetal cardiac function two-dimensional parameters using spectral and tissue Doppler. Pregnant women between 20 and 36 + 6 weeks gestation were divided into three groups: controls, type I DM, and type II DM. The right ventricle (RV) and left ventricle (LV) annular velocity peaks were measured using spectral (E, A) and tissue (E', A', S') Doppler. Read More

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http://dx.doi.org/10.1007/s10554-020-01821-9DOI Listing

Are the first-trimester levels of PAPP-A and fb-hCG predictors for obstetrical complications in diabetic pregnancy?

J Matern Fetal Neonatal Med 2020 Mar 30:1-7. Epub 2020 Mar 30.

Department of Obstetrics, Division of Maternal-Fetal Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, St. Petersburg, Russia.

To assess the levels of pregnancy-associated plasma protein-A (PAPP-A) and β-human chorionic gonadotropin (fb-hCG) in cases of diabetic pregnancy, to determine whether these biomarkers can be considered significant predictors for macrosomia, preeclampsia (PE), intrauterine growth restriction (IUGR), and preterm birth in mothers with different types of pregestational diabetes mellitus (DM). It was a retrospective cohort study. Study groups were presented: type 1 DM ( = 100), type 2 DM ( = 50), and controls ( = 25). Read More

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http://dx.doi.org/10.1080/14767058.2020.1743658DOI Listing

Fetal front-abdominal wall thickness in the second trimester as a predictor of abnormal fetal growth.

J Matern Fetal Neonatal Med 2020 Mar 24:1-7. Epub 2020 Mar 24.

Department of Obstetrics and Gynecology, Health Sciences University Kayseri City Hospital, Kayseri, Turkey.

Worldwide, approximately 9% of infants have a birth weight ≥4000 g, who are defined as fetal macrosomia, with wide variations between countries. Another form of abnormal fetal growth is fetal growth restriction. Infants with low birth weight (LBW) for their gestational age are primarily categorized as either small for gestational age (SGA) or fetal (intrauterine) growth restriction (FGR). Read More

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http://dx.doi.org/10.1080/14767058.2020.1743666DOI Listing

Identification of large-for-gestational age fetuses using antenatal customized fetal growth charts: Can we improve the prediction of abnormal labor course?

Eur J Obstet Gynecol Reprod Biol 2020 May 10;248:81-88. Epub 2020 Mar 10.

Department of Medicine and Surgery, Obstetrics and Gynaecology Unit, University of Parma, Parma, Italy. Electronic address:

Introduction: Fetal overgrowth is an acknowledged risk factor for abnormal labor course and maternal and perinatal complications. The objective of this study was to evaluate whether the use of antenatal ultrasound-based customized fetal growth charts in fetuses at risk for large-for-gestational age (LGA) allows a better identification of cases undergoing caesarean section due to intrapartum dystocia.

Material And Methods: An observational study involving four Italian tertiary centers was carried out. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.03.024DOI Listing
May 2020
1.627 Impact Factor

Novel variants of ABCC9 in Japanese children with Cantú syndrome.

Pediatr Int 2020 Mar 21;62(3):410-412. Epub 2020 Mar 21.

Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan.

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http://dx.doi.org/10.1111/ped.14098DOI Listing

DASH (Dietary Approaches to Stop Hypertension) dietary pattern and maternal blood pressure in pregnancy.

J Hum Nutr Diet 2020 Mar 20. Epub 2020 Mar 20.

UCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.

Background: High blood pressure (BP) in pregnancy is associated with significant adverse outcomes. In nonpregnant populations, the DASH (Dietary Approaches to Stop Hypertension) diet is associated with reductions in blood pressure. The present study investigated the relationship between the DASH dietary pattern and maternal BP in pregnancy. Read More

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http://dx.doi.org/10.1111/jhn.12744DOI Listing

Technology-supported lifestyle interventions to improve maternal-fetal outcomes in women with gestational diabetes mellitus: A meta-analysis.

Midwifery 2020 Jun 3;85:102689. Epub 2020 Mar 3.

School of Health Sciences, Wuhan University, Wuhan, China.

Background: The increasing incidence of gestational diabetes mellitus (GDM) is a global health problem. Lifestyle interventions have been recognized as effective measures to enhance maternal and child health. Traditional education approaches, personalized consultation and home visits to promote change in patients' lifestyle are limited by cost, lack of resources and inability to provide broad coverage. Read More

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http://dx.doi.org/10.1016/j.midw.2020.102689DOI Listing

Outcomes of Pregnancies Affected by Gestational Diabetes and Type 2 Diabetes in a Rural First Nations Obstetrical Program in Northwest Ontario.

Can J Diabetes 2020 Jan 12. Epub 2020 Jan 12.

Northern Ontario School of Medicine, Sioux Lookout, Ontario, Canada.

Objectives: In this work, we describe diabetes prevalence and birth outcomes in a primarily First Nations obstetrical population in northwest Ontario.

Methods: This retrospective, observational study of maternal and neonatal characteristics and birth outcomes was performed at the Sioux Lookout Meno Ya Win Health Centre between April 1, 2012 and March 31, 2017.

Results: The prevalence of pre-existing type 2 diabetes mellitus was 3. Read More

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http://dx.doi.org/10.1016/j.jcjd.2020.01.001DOI Listing
January 2020

Pregnancy outcomes in association with placental histopathology in pregnancies complicated by macrosomia in diabetic vs. non-diabetic women.

Eur J Obstet Gynecol Reprod Biol 2020 May 7;248:24-29. Epub 2020 Mar 7.

Departments of Obstetrics & Gynecology, The Edith Wolfson Medical Center, Holon, Israel(1).

Objective: We aimed to compare pregnancy outcomes in association with placental pathology in pregnancies complicated by macrosomia in diabetic vs. non-diabetic women.

Study Design: Pregnancies complicated by macrosomia (≥4000gr) were included. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.03.019DOI Listing

Effect of maternal body mass index on neonatal outcomes in women with endometriosis undergoing IVF.

Reprod Biomed Online 2020 Apr 23;40(4):559-567. Epub 2020 Jan 23.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated with JiaoTong University School of Medicine, Shanghai, China. Electronic address:

Research Question: Does preconception body mass index (BMI) affect neonatal outcomes in women with endometriosis who conceive with IVF?

Design: This retrospective study included 7086 women who delivered a singleton live birth through IVF between December 2006 and December 2017. Of these, 1111 women were diagnosed with endometriosis by laparoscopy or laparotomy, while 5975 women received IVF treatment due to tubal factor or male factor infertility. Women were categorized according to predefined BMI groups (<18. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.01.010DOI Listing

Pregnancy and perinatal outcomes in pregnancies resulting from time interval between a freeze-all cycle and a subsequent frozen-thawed single blastocyst transfer.

BMC Pregnancy Childbirth 2020 Mar 14;20(1):161. Epub 2020 Mar 14.

Department of Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 JieFang Avenue, Wuhan, 430030, People's Republic of China.

Background: Adverse obstetric outcomes are correlated with altered circulating hormone levels at the time implantation by the trophectoderm. What' more, embryo freezing process may also have adverse effect on perinatal outcomes. This study aims to evaluate whether increasing interval time between a freeze-all cycle and a subsequent frozen-thawed single blastocyst transfer could have any effect on pregnancy and perinatal outcomes. Read More

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http://dx.doi.org/10.1186/s12884-020-02858-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071692PMC

Association Between Maternal Normal Range HbA1c Values and Adverse Birth Outcomes.

J Clin Endocrinol Metab 2020 Jun;105(6)

Institute of Maternal and Child Health, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.

Context: Higher blood glucose level during gestational periods has been consistently associated with increased risk of adverse birth outcomes. Evidence regarding the association between higher glycated hemoglobin A1c (HbA1c) within the normal range and adverse birth outcomes is limited.

Objective: We aimed to examine the association between HbA1c within the normal range and the risk of adverse birth outcomes. Read More

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http://dx.doi.org/10.1210/clinem/dgaa127DOI Listing
June 2020
6.209 Impact Factor

Effects of maternal hepatitis B surface antigen positive status on the pregnancy outcomes: A retrospective study in Xiamen, China, 2011-2018.

PLoS One 2020 10;15(3):e0229732. Epub 2020 Mar 10.

Department of Endocrinology and Diabetes, the First Affiliated Hospital of Xiamen University, Xiamen, China.

Objective: Hepatitis B virus infection is a major social and economic burden in developing countries, especially in China. We aimed to evaluate the effects of hepatitis B surface antigen (HBsAg) positive status on the pregnancy outcomes in the Chinese population.

Methods: This retrospective cohort study was performed using data from the Medical Birth Registry of Xiamen, China, from January 2011 to March 2018. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229732PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064202PMC

Relationship between Maternal Body Mass Index and Obstetric and Perinatal Complications.

J Clin Med 2020 Mar 5;9(3). Epub 2020 Mar 5.

Department of Nursing, Faculty of Nursing of Ciudad Real, University of Castilla-La Mancha, 13071 Ciudad Real, Spain.

Over the past few decades, overweight and obesity have become a growing health problem of particular concern for women of reproductive age as obesity in pregnancy has been associated with increased risk of obstetric and neonatal complications. The objective of this study is to describe the incidence of obstetric and perinatal complications in relation to maternal body mass index (BMI) at the time prior to delivery within the Spanish Health System. For this purpose, a cross-sectional observational study was conducted aimed at women who have been mothers between 2013 and 2018 in Spain. Read More

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http://dx.doi.org/10.3390/jcm9030707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141254PMC

Towards Implementation of the Saint Vincent Declaration: Outcomes of Women with Pregestational Diabetes.

Isr Med Assoc J 2020 Mar;22(3):137-141

Department of Endocrinology, Sheba Medical Center, Tel Hashomer, Israel.

Background: Pregestational diabetes mellitus (PGDM) carries a significantly elevated risk of adverse maternal and fetal outcomes. There is evidence that certain interventions reduce the risk for adverse outcomes. Studies have shown that a multi-disciplinary approach improves pregnancy outcomes in women with PGDM. Read More

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Predictors of High Grade and Other Clinically Significant Placental Findings by Indication for Submission in Singleton Placentas From Term Births.

Pediatr Dev Pathol 2020 Mar 8:1093526620904801. Epub 2020 Mar 8.

Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Indications for placental submission are variable. Established guidelines are largely based on expert opinion, and there is a need for more evidence-based criteria. A 10-year database of term placentas was used to evaluate indications significantly associated with placental pathology. Read More

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http://dx.doi.org/10.1177/1093526620904801DOI Listing