4,415 results match your criteria Macrosomia


Epigenetic alteration of Rho guanine nucleotide exchange Factor 11 (ARHGEF11) in cord blood samples in macrosomia exposed to intrauterine hyperglycaemia.

J Matern Fetal Neonatal Med 2019 Apr 18:1-261. Epub 2019 Apr 18.

a Department of Obstetrics and Gynecology , Peking University First Hospital , Beijing , China.

Background: Macrosomia at birth is associated with maternal hyperglycaemia and leads to subsequent susceptibility to obesity, abnormal glucose metabolism, hypertension and dyslipidaemia in offspring. Epigenetic reprogramming has been reported to be involved in the development of human diseases caused by suboptimal environmental or nutritional factors. The study was aiming to explore epigenetic mechanism influences on macrosomic infants exposed to intrauterine hyperglycaemia. Read More

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http://dx.doi.org/10.1080/14767058.2019.1609929DOI Listing

Risk factors for recurrent macrosomia and child outcomes.

World J Pediatr 2019 Apr 16. Epub 2019 Apr 16.

Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Obstetrics and Gynecology Hospital of Fudan University, 128 Shen Yang Road, Shanghai, 200092, China.

Background: Women who had delivered a macrosomic newborn will have a higher risk to deliver another macrosomia. We aimed to examine the recurrence risk of macrosomia in the subsequent pregnancy and the implications in long-term child health.

Methods: Data from the Collaborative Perinatal Project, a longitudinal birth cohort with 54,371 singleton births, were used. Read More

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http://link.springer.com/10.1007/s12519-019-00249-z
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http://dx.doi.org/10.1007/s12519-019-00249-zDOI Listing
April 2019
2 Reads

An evaluation of whether a gestational weight gain of 5 to 9 kg for obese women optimizes maternal and neonatal health risks.

BMC Pregnancy Childbirth 2019 Apr 11;19(1):126. Epub 2019 Apr 11.

College of Veterinary Medicine and Biomedical Science, Texas A&M University, College Station, TX, 77843-4475, USA.

Background: Maternal obesity has a wide range of health effects on both the pregnant woman and developing fetus. The clinical significance of these disorders, combined with a dramatically increasing prevalence of obesity among pregnant women has precipitated a major health crisis in the United States. The most commonly used recommendations for gestational weight gain were established by the Institute of Medicine (IOM) in 2009 and have become well known and often adopted. Read More

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http://dx.doi.org/10.1186/s12884-019-2273-zDOI Listing
April 2019
1 Read

Risk factors and outcomes for neonatal hypoglycaemia and neonatal hyperbilirubinaemia in pregnancies complicated by gestational diabetes mellitus: a single centre retrospective 3-year review.

Diabet Med 2019 Apr 10. Epub 2019 Apr 10.

School of Medicine, Western Sydney University.

Aim: To determine risk factors associated with neonatal hypoglycaemia and hyperbilirubinaemia, and assess their impact on neonatal outcomes in pregnancies complicated by gestational diabetes mellitus (GDM).

Methods: Retrospective review investigating all pregnancies complicated by GDM at Campbelltown Hospital (Sydney, Australia) between 1 January 2013 and 31 December 2015. Main outcomes measured were neonatal hypoglycaemia (capillary glucose levels < 1. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dme.13962
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http://dx.doi.org/10.1111/dme.13962DOI Listing
April 2019
3 Reads

Oxygen radical disease in the newborn, revisited: Oxidative stress and disease in the newborn period.

Free Radic Biol Med 2019 Apr 5. Epub 2019 Apr 5.

Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States; Department of Pediatric Research, University of Oslo, Oslo University Hospital, Norway. Electronic address:

Thirty years ago, there was an emerging appreciation for the significance of oxidative stress in newborn disease. This prompted a renewed interest in the impact of oxygen therapy for the newborn in the delivery room and beyond, especially in premature infants. Today, the complexity of oxidative stress both in normal regulation and pathology is better understood, especially as it relates to neonatal mitochondrial oxidative stress responses to hyperoxia. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.03.035DOI Listing
April 2019
3 Reads

Early vs. standard screening and treatment of gestational diabetes in high-risk women - An attempt to determine relative advantages and disadvantages.

Nutr Metab Cardiovasc Dis 2019 Mar 1. Epub 2019 Mar 1.

Diabetes Section, University Hospital of Pisa, Italy.

Background And Aims: Screening for Gestational Diabetes (GDM) is usually recommended between 24 and 28 weeks of pregnancy; however available evidence suggests that GDM may be already present before recommended time for screening, in particular among high-risk women as those with prior GDM or obesity. The purpose of this retrospective study was to evaluate whether early screening (16-18 weeks) and treatment of GDM may improve maternal and fetal outcomes.

Methods And Results: In 290 women at high-risk for GDM, we analyzed maternal and fetal outcomes, according to early or standard screening and GDM diagnosis time. Read More

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http://dx.doi.org/10.1016/j.numecd.2019.02.007DOI Listing
March 2019
1 Read

Human Reproductive Cell Cryopreservation, Storage, Handling, and Transport: Risks and Risk Management.

Semin Reprod Med 2018 Sep 4;36(5):265-272. Epub 2019 Apr 4.

Reproductive Medicine Unit, GynePro Medical Centers, Bologna, Italy.

Millions of human oocytes and embryos are stored in thousands of locations across the globe. This inventory continues to grow as cryopreservation becomes more successful and more widely applied. The results of studies assessing pregnancy and neonatal outcomes following frozen embryo transfer (FET) have been encouraging, showing lower incidences of small for gestational age neonates and preterm birth compared with fresh transfers. Read More

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http://dx.doi.org/10.1055/s-0038-1676849DOI Listing
September 2018
3 Reads

Prevalence, Risk Factors, and Fetomaternal Outcomes of Gestational Diabetes Mellitus in Kuwait: A Cross-Sectional Study.

J Diabetes Res 2019 3;2019:9136250. Epub 2019 Mar 3.

Department of Community Medicine and Behavioral Sciences, Faculty of Medicine, Kuwait University, Safat, Kuwait.

Objective: Gestational diabetes mellitus (GDM) is a growing global public health problem that can have short- and long-term health consequences for the mother and the child. Despite its criticalness, many countries still do not have the epidemiological data which could guide them in responding to the problem. Due to the lack of knowledge on GDM and the fact that diabetes and obesity are high in Kuwait, this study sought to estimate the prevalence of GDM and determine its risk factors and outcomes. Read More

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http://dx.doi.org/10.1155/2019/9136250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421795PMC

Gestational Weight Gain among Healthy Pregnant Women from Asia in Comparison with Institute of Medicine (IOM) Guidelines-2009: A Systematic Review.

J Pregnancy 2019 3;2019:3849596. Epub 2019 Mar 3.

Department of Food and Nutrition, Institute of Home Economics, Delhi University, F-4, Hauz Khas Enclave, New Delhi, India.

In 1990, Institute of Medicine (IOM) recommended gestational weight gain (GWG) ranges for women in the United States primarily to improve infant birth weight. Changes in key aspects of reproductive health of women of child bearing age, a rising prevalence of obesity, and noncommunicable diseases prompted the revision of IOM guidelines in 2009. However, there is no such recommendation available for Asian women. Read More

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http://dx.doi.org/10.1155/2019/3849596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421048PMC
March 2019
2 Reads

Clinical and pathological findings for rabbits with dystocia: 10 cases (1996-2016).

J Am Vet Med Assoc 2019 Apr;254(8):953-959

Objective: To characterize clinical and pathological findings of rabbits evaluated at a veterinary teaching hospital because of dystocia.

Design: Retrospective case series.

Animals: 9 client-owned rabbits and 1 wild rabbit with signs of dystocia evaluated at a veterinary teaching hospital from 1996 through 2016. Read More

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http://dx.doi.org/10.2460/javma.254.8.953DOI Listing
April 2019
1 Read

Maternal and neonatal complications of fetal macrosomia: a systematic review and meta-analysis.

Ultrasound Obstet Gynecol 2019 Apr 2. Epub 2019 Apr 2.

Fetal Medicine Unit, Medway NHS Foundation Trust, United Kingdom.

Objectives: To determine accurate estimates of maternal and neonatal risks of fetal macrosomia by undertaking a systematic review and meta-analysis METHODS: A search of MEDLINE, EMBASE, CINHAL and The Cochrane Library was performed to review relevant citations reporting maternal and neonatal complications of pregnancies with macrosomia with birthweight (BW) >4,000g and >4,500g. We selected prospective and retrospective cohort and population studies that provided data regarding both, cases and controls. Meta-analysis using random effects model was used to estimate weighted pooled estimates of summary statistics (odds ratio (OR) [95% confidence intervals (CI)]). Read More

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http://dx.doi.org/10.1002/uog.20279DOI Listing
April 2019
2 Reads

Maternal and neonatal complications of fetal macrosomia.

Ultrasound Obstet Gynecol 2019 Apr 2. Epub 2019 Apr 2.

Fetal Medicine Unit, Medway NHS Foundation Trust, United Kingdom.

Objective: To estimate risks of maternal and neonatal complications in pregnancies with macrosomia.

Method: This was a retrospective cohort study undertaken at a large maternity unit in United Kingdom between January 2009-December 2016. We compared the incidence of complications in pregnancies with macrosomia, defined by birthweight (BW)>4,000 g and severe macrosomia with BW>4,500 g, to those in pregnancies with normal BW 2,500-4,000 g. Read More

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http://dx.doi.org/10.1002/uog.20278DOI Listing
April 2019
2 Reads

WIC Food Package Changes: Trends in Childhood Obesity Prevalence.

Pediatrics 2019 Apr 1. Epub 2019 Apr 1.

Social and Behavioral Sciences and

Objectives: To evaluate the association of the 2009 changes to the US Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) food package and childhood obesity trends. We hypothesized that the food package change reduced obesity among children participating in WIC, a population that has been especially vulnerable to the childhood obesity epidemic.

Methods: We used an interrupted time-series design with repeated cross-sectional measurements of state-specific obesity prevalence among WIC-participating 2- to 4-year-old children from 2000 to 2014. Read More

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http://dx.doi.org/10.1542/peds.2018-2841DOI Listing
April 2019
1 Read

The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes.

BMC Pregnancy Childbirth 2019 Mar 29;19(1):107. Epub 2019 Mar 29.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran.

Background: Diabetes is the most common medical condition in pregnant women and its complications affect both mother and fetus. The beneficial effects of vitamin D on gestational diabetes have been shown, though data on the effects of co-administration of vitamin D with other nutrients on pregnancy outcomes in gestational diabetes (GDM) are scarce. This study was aimed to determine the effects of magnesium-zinc-calcium-vitamin D co-supplementation on parameters of inflammation and oxidative stress, and pregnancy outcomes among women with GDM. Read More

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http://dx.doi.org/10.1186/s12884-019-2258-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440090PMC
March 2019
1 Read

Maternal body mass index and risk of neonatal adverse outcomes in China: a systematic review and meta-analysis.

BMC Pregnancy Childbirth 2019 Mar 29;19(1):105. Epub 2019 Mar 29.

School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, 110122, People's Republic of China.

Background: Maternal body mass index is linked to short- and long-term unfavorable health outcomes both for child and mother. We conducted a systematic review and meta-analysis of population-based cohort studies to evaluate maternal BMI and the risk of harmful neonatal outcomes in China.

Methods: Six databases identified 2454 articles; 46 met the inclusion criteria for this study. Read More

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http://dx.doi.org/10.1186/s12884-019-2249-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440121PMC
March 2019
1 Read
2.190 Impact Factor

Protocol for the prospective observational clinical study: estimation of fetal weight by MRI to PREdict neonatal MACROsomia (PREMACRO study) and small-for-gestational age neonates.

BMJ Open 2019 Mar 27;9(3):e027160. Epub 2019 Mar 27.

Department of Obstetrics and Gynecology, University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium.

Introduction: Macrosomia refers to growth beyond a specific threshold, regardless of gestational age. These fetuses are also frequently referred to as large for gestational age (LGA). Various cut-offs have been used but for research purposes, a cut-off above the 95th centile for birth weight is often preferred because it defines 90% of the population as normal weight. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027160DOI Listing
March 2019
3 Reads

First-trimester proteomic profiling identifies novel predictors of gestational diabetes mellitus.

PLoS One 2019 27;14(3):e0214457. Epub 2019 Mar 27.

Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.

Background: Gestational diabetes mellitus (GDM) is a common pregnancy complication associated with adverse outcomes including preeclampsia, caesarean section, macrosomia, neonatal morbidity and future development of type 2 diabetes in both mother and child. Current selective screening strategies rely on clinical risk factors such as age, family history of diabetes, macrosomia or GDM in a previous pregnancy, and they possess a relatively low specificity. Here we hypothesize that novel first trimester protein predictors of GDM can contribute to the current selective screening strategies for early and accurate prediction of GDM, thus allowing for timely interventions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214457PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436752PMC
March 2019
1 Read

Neonatal and maternal outcome after frozen embryo transfer: increased risks in programmed cycles.

Am J Obstet Gynecol 2019 Mar 22. Epub 2019 Mar 22.

Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, Gothenburg University, Reproductive Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.

Background: Frozen embryo transfer is associated with better perinatal outcome regarding preterm birth and low birth weight yet higher risk of large for gestational age and macrosomia compared to fresh transfer. Further, higher rates of hypertensive disorders in pregnancy are noted after frozen embryo transfer. Whether these differences are due to the protocol used in frozen cycles remains unknown. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.03.010DOI Listing
March 2019
1 Read

Comparison of the accuracy of INTERGROWTH-21 formula with other ultrasound formulae in fetal weight estimation.

Taiwan J Obstet Gynecol 2019 Mar;58(2):273-277

Department of Obstetrics and Gynaecology, United Christian Hospital, Hong Kong.

Objective: A new ultrasound formula for fetal weight estimation was proposed from the INTERGROWTH-21 project in 2017. There is no comparison of its accuracy with other ultrasound formulae. This study aims to compare the accuracy of INTERGROWTH-21 formula in fetal weight estimation with the traditional Hadlock1 and Shepard formula. Read More

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http://dx.doi.org/10.1016/j.tjog.2019.01.019DOI Listing
March 2019
2 Reads

Water Birth Maternal and Neonatal Outcomes Among Midwifery Clients in Alberta, Canada, from 2014 to 2017: A Retrospective Study.

J Obstet Gynaecol Can 2019 Mar 21. Epub 2019 Mar 21.

Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Alberta, AB.

Objectives: This study sought to evaluate retrospectively the maternal and neonatal outcomes of water births (WBs) managed by Registered Midwives in Alberta compared with traditional or "land" vaginal birth outcomes for clinical evidence or knowledge and to assist in health care management planning.

Methods: This study was a retrospective cohort comparison of maternal and neonatal outcomes of WB (1716) and traditional or land birth (non-WB) (21 320) from selected low-risk maternal cohorts with spontaneous onset of labour and vaginal delivery in Alberta (2014-2017) using Alberta Perinatal Health Program data sets. Anonymized client and patient records linked the Alberta Perinatal Health Program data with inpatient Discharge Abstract Database for newborn and/or maternal personal health number (PHN/ULI) analyzed using SPSS 19. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.12.014DOI Listing
March 2019
1 Read

Gestational diabetes mellitus and macrosomia predispose to diabetes in the Lebanese population.

J Clin Transl Endocrinol 2019 Jun 20;16:100185. Epub 2019 Feb 20.

School of Medicine, Lebanese American University, Beirut, Lebanon.

Aims: The Middle East has the fastest rising rate of Type 2 Diabetes Mellitus (T2DM) worldwide, with Lebanon having 15.8% of its population affected. This study aims at studying Polycystic Ovarian Syndrome (PCOS), Gestational Diabetes Mellitus (GDM), and macrosomia as risk factors of T2DM in Lebanon. Read More

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http://dx.doi.org/10.1016/j.jcte.2019.100185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406007PMC
June 2019
1 Read

Study on the relationship between the levels of irisin in umbilical cord blood and neonatal growth in China.

J Matern Fetal Neonatal Med 2019 Mar 28:1-6. Epub 2019 Mar 28.

a Department of Women and Children Health, School of Public Health , Shandong University , Jinan City , China.

Objective: The results of the study on the relationship between obesity and cord blood irisin were far apart. The aim of this study was to explore the relationship between cord blood irisin levels and neonatal growth in China.

Methods: A cross-sectional study of 400 neonates and their mothers was conducted in the obstetrics department of Shandong provincial hospital in China. Read More

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http://dx.doi.org/10.1080/14767058.2019.1597843DOI Listing
March 2019
3 Reads

Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes.

Endocr Connect 2019 Mar 1. Epub 2019 Mar 1.

J Hua, Department of Women and Children's Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Background: The effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial.

Methods: This was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy who sought antenatal examination between January 2014 and December 2015 at Shanghai First Maternity and Infant Hospital were extracted from the electronic medical records system. Read More

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http://dx.doi.org/10.1530/EC-19-0088DOI Listing
March 2019
2 Reads

Association of first-trimester HbA1c levels with adverse pregnancy outcomes in different ethnic groups.

Diabetes Res Clin Pract 2019 Mar 15;150:202-210. Epub 2019 Mar 15.

Department of Endocrinology and Nutrition, Hospital del Mar, E-08003 Barcelona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, E-08003 Barcelona, Spain. Electronic address:

Aim: To determine, in a multi-ethnic cohort, the association of first-trimester HbA1c levels with the development of pregnancy complications.

Methods: A prospective study between April 2013-October 2016. Participants were stratified in five ethnic groups. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183149
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http://dx.doi.org/10.1016/j.diabres.2019.03.017DOI Listing
March 2019
8 Reads

The Protective Effect of Prenatal Social Support on Infant Adiposity in the First 18 Months of Life.

J Pediatr 2019 Mar 14. Epub 2019 Mar 14.

Division of General Pediatrics, Department of Pediatrics, New York University School of Medicine, New York, NY.

Objective: To determine whether prenatal social support was associated with infant adiposity in the first 18 months of life in a low-income, Hispanic sample, known to be at high risk of early child obesity.

Study Design: We performed a longitudinal analysis of 262 low-income, Hispanic mother-infant pairs in the control group of the Starting Early child obesity prevention trial. Prenatal social support was measured using an item from the Maternal Social Support Index. Read More

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http://dx.doi.org/10.1016/j.jpeds.2019.02.017DOI Listing
March 2019
1 Read

Pregnancy Outcomes of Women Additionally Diagnosed as Gestational Diabetes by the International Association of the Diabetes and Pregnancy Study Groups Criteria.

Diabetes Metab J 2019 Feb 28. Epub 2019 Feb 28.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background: We investigated the pregnancy outcomes in women who were diagnosed with gestational diabetes mellitus (GDM) by the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria but not by the Carpenter-Coustan (CC) criteria.

Methods: A total of 8,735 Korean pregnant women were identified at two hospitals between 2014 and 2016. Among them, 2,038 women participated in the prospective cohort to investigate pregnancy outcomes. Read More

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https://e-dmj.org/DOIx.php?id=10.4093/dmj.2018.0192
Publisher Site
http://dx.doi.org/10.4093/dmj.2018.0192DOI Listing
February 2019
2 Reads

Progression to Gestational Diabetes Mellitus in Pregnant Women with One Abnormal Value in Repeated Oral Glucose Tolerance Tests.

Diabetes Metab J 2019 Feb 28. Epub 2019 Feb 28.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated.

Methods: To identify clinical and metabolic predictors for GDM in women with OAV, we conducted a retrospective study and identified women with OAV in the OGTT done at 24 to 30 weeks gestational age (GA) and repeated the second OGTT between 32 and 34 weeks of GA. Read More

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https://e-dmj.org/DOIx.php?id=10.4093/dmj.2018.0159
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http://dx.doi.org/10.4093/dmj.2018.0159DOI Listing
February 2019
5 Reads

Altered development of fetal liver perfusion in pregnancies with pregestational diabetes.

PLoS One 2019 13;14(3):e0211788. Epub 2019 Mar 13.

Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.

Background: Pregestational diabetes is associated with fetal macrosomia, and umbilical perfusion of the fetal liver has a role in regulating fetal growth. We therefore hypothesized that pregestational diabetes alters fetal liver blood flow depending on degree of glycemic control.

Methods: In a prospective study, 49 women with pregestational diabetes underwent monthly ultrasound examinations during 24-36 gestational weeks. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211788PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415794PMC
March 2019
1 Read

Trends in prevalence of gestational diabetes and perinatal outcomes in Catalonia, Spain, 2006 to 2015: the Diagestcat Study.

Diabetes Metab Res Rev 2019 Mar 13:e3151. Epub 2019 Mar 13.

Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain.

Background: No recent epidemiologic studies on gestational diabetes mellitus (GDM) have been conducted in Spain. The present study aimed to explore trends in the prevalence of GDM and ascertain whether the risk of adverse perinatal outcomes changed between 2006 and 2015 in Catalonia.

Methods: In this population-based study, all hospital admissions for singleton births in Catalonia for the period 2006 to 2015 were collected from the Spanish Minimum Basic Data Set. Read More

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http://dx.doi.org/10.1002/dmrr.3151DOI Listing
March 2019
4 Reads

Role of omega-3 polyunsaturated fatty acids in gestational diabetes, maternal and fetal insights: current use and future directions.

J Matern Fetal Neonatal Med 2019 Mar 27:1-13. Epub 2019 Mar 27.

c Department of Pharmacy, Faculty of Medicine , University of Prishtina , Prishtina , Kosovo.

ω-3-Polyunsaturated fatty acids (ω-3 PUFAs) are widely used during pregnancy and gestational diabetes mellitus (GDM). ω-3 PUFAs are beneficial in the regulation of maternal and fetal metabolic function, inflammation, immunity, macrosomia (MAC), oxidative stress, preeclampsia, intrauterine growth, preterm birth, offspring metabolic function, and neurodevelopment. Dietary counseling is vital for improving therapeutic outcomes in patients with GDM. Read More

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http://dx.doi.org/10.1080/14767058.2019.1593361DOI Listing
March 2019
4 Reads

Second-trimester maternal lipid profiles predict pregnancy complications in an age-dependent manner.

Arch Gynecol Obstet 2019 May 5;299(5):1253-1260. Epub 2019 Mar 5.

Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, 310006, China.

Purpose: Our objective was to investigate the combinatorial effect of maternal age and second-trimester maternal lipid profiles for pregnancy complications.

Methods: With 1:4 matching, this retrospective study selected 499 advanced maternal age women and 1996 younger controls. Logistic regression analysis was used to estimate the correlation between second-trimester lipid profiles [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)] and pregnancy complications [gestational diabetes mellitus (GDM), pregnancy-induced hypertension syndrome (PIH), preterm labor (PTL), and macrosomia]. Read More

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http://dx.doi.org/10.1007/s00404-019-05094-zDOI Listing
May 2019
6 Reads

Effects of maternal obesity, excessive gestational weight gain and fetal macrosomia on the frequency of cesarean deliveries among migrant and non-migrant women - a prospective study.

J Perinat Med 2019 Feb 28. Epub 2019 Feb 28.

Department of Gynecology, Charité University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany.

Background Maternal obesity, excessive gestational weight gain and fetal macrosomia may affect the health of the mother and the newborn, and are associated with cesarean delivery. Pregnant women with a migration background have a higher risk of obesity but nevertheless a lower frequency of cesarean deliveries than women from the majority population. This study assesses which of these factors most influence the risk of a cesarean delivery and whether their prevalence can explain the lower cesarean rates in migrant women. Read More

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http://dx.doi.org/10.1515/jpm-2018-0399DOI Listing
February 2019
1 Read

A Simulation-Based Workshop to Improve Residents' Collaborative Clinical Practice.

J Grad Med Educ 2019 Feb;11(1):66-71

Background: The Accreditation Council for Graduate Medical Education expects residents to attain competency in systems-based practice by advocating for quality patient care, working in interprofessional teams, and implementing system solutions to prevent errors. Diabetes in pregnancy was identified as an area for improvement through comprehensive interdisciplinary and interprofessional care.

Objective: An interdisciplinary and interprofessional workshop was created by 3 regional academic institutions to improve collaborative practice, clinical knowledge, and clinical judgment of residents. Read More

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http://dx.doi.org/10.4300/JGME-D-18-00209.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375322PMC
February 2019
1 Read

Associations of maternal, perinatal and postnatal factors with the eruption timing of the first primary tooth.

Sci Rep 2019 Feb 25;9(1):2645. Epub 2019 Feb 25.

Department of Polyclinics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210029, China.

We recruited 1296 mothers in their first trimester from the Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University between May 2014 and September 2015 to investigate the associations of maternal, perinatal and postnatal factors with the eruption timing of the first primary tooth (ETFPT) in a Chinese population. We collected maternal demographic information and clinical data during the perinatal and postnatal period, and oral examinations of the infants were performed by a doctor at 6, 9 and 12 months of age. Multiple regression analysis was used to identify significant explanatory variables for ETFPT. Read More

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http://dx.doi.org/10.1038/s41598-019-39572-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390108PMC
February 2019
1 Read

Changing trends of adverse pregnancy outcomes with maternal age in primipara with singleton birth: a join-point analysis of a multicenter historical cohort study in China in 2011-2012.

Acta Obstet Gynecol Scand 2019 Feb 24. Epub 2019 Feb 24.

Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Introduction: Adverse pregnancy outcomes are related to two opposite maternal factors, youth and aging. However, the change in trend of specific outcomes with childbearing age is unknown. The aim of this study was to investigate the changing trend of various maternal and neonatal outcomes with maternal age from 17 to 44 years. Read More

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http://dx.doi.org/10.1111/aogs.13595DOI Listing
February 2019
3 Reads

Tissue variations of mosaic genome-wide paternal uniparental disomy and phenotype of multi-syndromal congenital hyperinsulinism.

Eur J Med Genet 2019 Feb 21. Epub 2019 Feb 21.

Odense Pancreas Center (OPAC), Odense University Hospital, Odense, Denmark; Institute of Clinical Research, University of Southern Denmark Odense, Odense, Denmark; Dept. of Pathology, Odense University Hospital, Odense, Denmark.

Mosaic genome-wide paternal uniparental disomy (GW-pUPD) is a rarely recognised disorder. The phenotypic manifestations of multilocus imprinting defects (MLIDs) remain unclear. We report of an apparently non-syndromic infant with severe congenital hyperinsulinism (CHI) and diffuse pancreatic labelling by 18F*-DOPA-PET/CT leading to near-total pancreatectomy. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.02.004DOI Listing
February 2019
1 Read

Aberrant expression of oxidative stress related proteins affects the pregnancy outcome of gestational diabetes mellitus patients.

Am J Transl Res 2019 15;11(1):269-279. Epub 2019 Jan 15.

School of Medicine, Shanghai Jiao Tong University Shanghai 200025, China.

Gestational diabetemellitus (GDM) is a condition whereby a mother's glucose tolerance is impaired with onset or first recognition during pregnancy which is not either type 1 or type 2 diabetes mellitus. Oxidative stress plays an essential role in diabetes, however, whether it also includes in GDM has not been fully clarified. Therefore, we investigated the changes of oxidative stress biomarkers and their relationship with pregnancy outcomes in patients with GDM. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357329PMC
January 2019
1 Read

Prenatal imaging throughout gestation in Beckwith-Wiedemann syndrome.

Prenat Diagn 2019 Feb 19. Epub 2019 Feb 19.

Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Purpose: Prenatal occurrence and timing of appearance of associated features in Beckwith-Wiedemann syndrome (BWS) are unknown. We reviewed our BWS patients with serial fetal imaging and correlated these with postnatal findings.

Methods: All BWS patients with fetal ultrasound (US) or magnetic resonance imaging (MRI) from 2000 to 2016 were reviewed to determine the presence of polyhydramnios, placentamegaly, macrosomia, macroglossia, retrognathia, omphalocele, visceromegaly, and hemihypertrophy. Read More

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http://dx.doi.org/10.1002/pd.5440DOI Listing
February 2019
2 Reads

Pregnancy outcomes of early detected gestational diabetes: a retrospective comparison cohort study, Qatar.

BMJ Open 2019 Feb 19;9(2):e023612. Epub 2019 Feb 19.

Department of Endocrinology, Qatar Metabolic Institute, Hamad Medical Corporation, Doha, Qatar.

Objective: To compare pregnancy outcomes in patients with early versus usual gestational diabetes mellitus (GDM).

Design: A retrospective cohort study.

Settings: The Women's Hospital, Hamad Medical Corporation, Qatar. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377515PMC
February 2019
3 Reads

Risk of adverse pregnancy outcomes by pre-pregnancy Body Mass Index among Italian population: a retrospective population-based cohort study on 27,807 deliveries.

Arch Gynecol Obstet 2019 Apr 15;299(4):983-991. Epub 2019 Feb 15.

Division of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC) Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Purpose: To estimate the impact of increasing pre-pregnancy Body Mass Index (BMI) on the risk of adverse maternal and perinatal outcomes, in patients who delivered in an Italian tertiary care Obstetric department.

Methods: Data, related to women who delivered at Sant'Anna Hospital, Turin, between 2011 and 2015, were collected retrospectively from the hospital database. According to BMI, women were considered as normal weight, overweight, and class 1, 2 and 3 obese (WHO criteria). Read More

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http://dx.doi.org/10.1007/s00404-019-05093-0DOI Listing
April 2019
5 Reads

Induction of labor at 39 weeks of gestation versus expectant management for low-risk nulliparous women: a cost-effectiveness analysis.

Am J Obstet Gynecol 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR.

Background: A large, recent multicenter trial found that induction of labor at 39 weeks for low-risk nulliparous women was not associated with an increased risk of cesarean delivery or adverse neonatal outcomes.

Objective: We sought to examine the cost-effectiveness and outcomes associated with induction of labor at 39 weeks vs expectant management for low-risk nulliparous women in the United States.

Study Design: A cost-effectiveness model using TreeAge software was designed to compare outcomes in women who were induced at 39 weeks vs expectantly managed. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.017DOI Listing
February 2019
4 Reads

Pregnancy Outcomes in Women with Strictly Controlled Type 1 Diabetes Mellitus.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):798-800

Department of Obstetrics and Gynecology, Trakya University, Edirne, Turkey.

Objective: To evaluate the pregnancy outcomes in mothers with controlled Type 1 diabetes mellitus (T1DM).

Materials And Methods: Thirty seven pregnant patients with controlled T1DM were included in the study.

Results: Twenty (54%) out of 37 patients had preterm delivery (<37 weeks of gestation). Read More

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http://dx.doi.org/10.4103/ijem.IJEM_139_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330866PMC
February 2019

Effects of nutritional nursing intervention based on glycemic load for patient with gestational diabetes mellitus.

Ginekol Pol 2019 ;90(1):46-49

Department of Gynecology and Obstetrics, Yantai Hospital of Traditional Chinese Medicine, Yantai City, China.

Objectives: To determine the effects of nutritional nursing intervention based on glycemic load (GL) for patients with gestational diabetes mellitus.

Material And Methods: One hundred thirty-four patients diagnosed with gestational diabetes mellitus at our hospital were selected from March 2015 to March 2017 and randomly divided into the observation (n = 67) and control groups (n = 67). All of the patients in the observation and control groups received conventional nutritional nursing. Read More

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http://dx.doi.org/10.5603/GP.2019.0007DOI Listing
January 2019
4 Reads

Maternal Dietary Patterns and Their Association with Pregnancy Outcomes.

Clin Nutr Res 2019 Jan 25;8(1):64-73. Epub 2019 Jan 25.

Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

Maternal nutritional status during pregnancy will affect the outcomes for the mother and the newborn. Maternal diet was assessed in 150 pregnant women during the first trimester of pregnancy by a 168-item food frequency questionnaire. Dietary patterns were explored by Factor analysis, and association of patterns with maternal and neonatal outcomes such as gestational diabetes mellitus (GDM), anemia and anthropometric indices were determined by analysis of variance and linear regression analysis. Read More

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http://dx.doi.org/10.7762/cnr.2019.8.1.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355947PMC
January 2019
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Trial of labor after cesarean section in risk pregnancies: A population-based cohort study.

Acta Obstet Gynecol Scand 2019 Feb 8. Epub 2019 Feb 8.

Department of Clinical Science, University of Bergen, Bergen, Norway.

Introduction: In most pregnancies after a cesarean section, a trial of labor is an option. The objective of the study was to explore trial of labor and its failure in pregnancies with medical risk conditions, in a population with a high trial of labor rate.

Material And Methods: In a cohort study (n = 57 109), using data from the Medical Birth Registry of Norway 1989-2014, women with a second delivery after a first pregnancy cesarean section were included. Read More

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http://dx.doi.org/10.1111/aogs.13565DOI Listing
February 2019
4 Reads

The Association between Advanced Maternal Age and Macrosomia: A Meta-Analysis.

Child Obes 2019 Apr 7;15(3):149-155. Epub 2019 Feb 7.

2 Medical Department, Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, China.

Purpose: The aim of our meta-analysis was to explore whether advanced maternal age (AMA) is regarded as an important risk factor for predicting macrosomia or not.

Methods: Three databases were systematically reviewed and reference lists of relevant articles were checked. Meta-analysis of published cohort studies was done comparing whether AMA was associated with macrosomia and adjusting for potential confounding factors. Read More

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https://www.liebertpub.com/doi/10.1089/chi.2018.0258
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http://dx.doi.org/10.1089/chi.2018.0258DOI Listing
April 2019
8 Reads

Maternal and newborn outcomes with elective induction of labor at term.

Am J Obstet Gynecol 2019 Mar 17;220(3):273.e1-273.e11. Epub 2019 Feb 17.

Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR.

Background: A growing body of evidence supports improved or not worsened birth outcomes with nonmedically indicated induction of labor at 39 weeks gestation compared with expectant management. This evidence includes 2 recent randomized control trials. However, concern has been raised as to whether these studies are applicable to a broader US pregnant population. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.223DOI Listing
March 2019
3 Reads

Maternal and perinatal outcomes in pregnant women with BMI >50: An international collaborative study.

PLoS One 2019 4;14(2):e0211278. Epub 2019 Feb 4.

National Perinatal Epidemiology Unit (NPEU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

Objective: To examine the association between maternal BMI>50kg/m2 during pregnancy and maternal and perinatal outcomes.

Materials And Methods: An international cohort study was conducted using data from separate national studies in the UK and Australia. Outcomes of pregnant women with BMI>50 were compared to those of pregnant women with BMI<50. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211278PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361432PMC
February 2019
7 Reads

Should HbA1C be used to screen pregnant women for undiagnosed diabetes in the first trimester? A review of the evidence.

J Public Health (Oxf) 2019 Jan 31. Epub 2019 Jan 31.

Public Health Wales NHS Trust, Cardiff, UK.

Background: Diabetes in pregnancy is associated with miscarriage, stillbirth, congenital abnormalities, macrosomia and perinatal mortality. The demographics of the population becoming pregnant has changed (more obese and older women). More women are therefore entering pregnancy with undiagnosed diabetes. Read More

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http://dx.doi.org/10.1093/pubmed/fdy229DOI Listing
January 2019
3 Reads

Large for gestational age and macrosomia in pregnancies without gestational diabetes mellitus.

J Matern Fetal Neonatal Med 2019 Feb 17:1-10. Epub 2019 Feb 17.

a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , China.

Objective: This study aims to estimate the prevalence and risk factors of macrosomia and LGA (large for gestational age) in non-GDM (gestational diabetes mellitus) pregnant women in Fuyang, Anhui Province of China.

Methods: A large population-based cohort study was conducted among non-GDM pregnant women aged 18-45 years. Maternal sociodemographic data prior to pregnancy were collected using interviewer-administered standardized questionnaire. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1578746DOI Listing
February 2019
11 Reads