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Medicina (Kaunas) 2022 Mar 30;58(4). Epub 2022 Mar 30.

Department of Orthopedics, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.

Osteoporosis and anemia are prevalent among chronic kidney disease stage 5D (CKD stage 5D) patients. Osteoblasts are known as the niche cells of hematopoietic stem cells (HSCs) and stimulate HSCs to form blood-cell lineages within bone marrow microenvironments. We hypothesized that an inverse correlation may exist between mean corpuscular volume (MCV), a surrogate for ineffective hematopoiesis, and bone mineral density (BMD) in the CKD stage 5D population. Read More

Cureus 2022 Mar 14;14(3):e23152. Epub 2022 Mar 14.

Internal Medicine, Centro Hospitalar de Entre Douro e Vouga, Santa Maria da Feira, PRT.

Macrocytosis is defined as a mean corpuscular volume greater than 100 femtolitres (fL). There are several causes for macrocytic anaemia, and they can be divided into megaloblastic or non-megaloblastic anaemia. Vitamin B12 deficiency is one of the most common causes of megaloblastic anaemia. Read More

Respirology 2022 Apr 13. Epub 2022 Apr 13.

ILD Center of Excellence, Department of Pulmonology, St. Antonius Hospital, Nieuwegein, The Netherlands.

Background And Objective: Idiopathic pulmonary fibrosis (IPF) is a heterogenous disease with a median survival of 3-4 years. Patients with mutations in telomere-related genes exhibit extrapulmonary signs and symptoms. These patients represent a distinct phenotype of IPF with worse survival. Read More

Perm J 2021 05 12;25. Epub 2021 May 12.

Department of Oncology, Kaiser Permanente San Jose Medical Center, San Jose, CA.

Introduction: The landmark value of mean corpuscular volume (MCV) in the diagnosis and classification of anemias has been established more than a century ago. In contrast, the importance of MCV assessment in patients with elevated hemoglobin and hematocrit is not nearly as appreciated.

Case Presentation: This case describes a patient who exhibited long-standing macrocytosis (elevated MCV) that contributed to elevated hemoglobin and hematocrit levels thus mimicking a diagnosis of polycythemia vera. Read More

Cureus 2022 Jan 13;14(1):e21214. Epub 2022 Jan 13.

Internal Medicine, Grand Strand Medical Center, Myrtle Beach, USA.

Nitrous oxide is clinically used as an inhaled anesthetic in surgical and dental procedures. It is also used as an inhaled recreational drug and can be incredibly addictive. It tends to irreversibly oxidize cobalamin (Vitamin B12), rendering it inactive as a coenzyme in the production of methionine. Read More

Cureus 2021 Dec 27;13(12):e20741. Epub 2021 Dec 27.

Pediatric Hematology/Oncology, Maternity and Children Hospital, Ministry of Health, Al-Ahsa, SAU.

Vitamin B12 is an essential water-soluble vitamin that mediates multiple coenzymes needed for cell synthesis, mainly the red blood cells. Its deficiency is characterized by megaloblastic anemia and neuropsychiatric symptoms. Macrocytosis is the classical picture seen usually, but having microcytosis is unlikely. Read More

Mol Biol Rep 2022 Mar 18;49(3):1985-1994. Epub 2022 Jan 18.

Institute of Zoology, University of the Punjab, Q-A- Campus, Lahore, 54590, Pakistan.

Background: Disproportionate fatty diet intake provokes hepatic lipid accumulation that causes non-alcoholic fatty liver disease, triggering the embryonically conserved Hedgehog (Hh) pathway in the adult liver. The present study incorporates exploring the impact of chronically administered unsaturated (D-1) and saturated (D-2) fat-enriched diets on hematological parameters, liver functioning, and lipid profile in the rat model. Besides, hepatohistology and real time gene expression analysis of Hh signaling pathway genes i. Read More

Med J Armed Forces India 2022 Jan 23;78(1):94-98. Epub 2021 Feb 23.

ADH, HQ Delhi Area, India.

Background: Vitamin B12 deficiency is an easily treatable cause of reversible dementia. It is likely to be more common in Indian population due to traditionally vegetarian culture. This study was conducted to estimate the prevalence of Vitamin B12 deficiency in elderly patients (>60 years) with dementia attending outpatient department. Read More

J Dent Sci 2022 Jan 3;17(1):106-112. Epub 2021 Jul 3.

Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background/purpose: Our previous study found that 222 of 884 burning mouth syndrome (BMS) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity but without gastric parietal cell antibody positivity (GPCA-TGA/TMABMS patients). This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-TGA/TMABMS patients.

Materials And Methods: The complete blood count, iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 222 GPCA-TGA/TMABMS patients and 553 GPCA-negative, TGA-negative, and TMA-negative BMS patients (GPCA-TGA-TMA-BMS patients) or 442 healthy control subjects. Read More

J Dent Sci 2022 Jan 21;17(1):57-62. Epub 2021 Aug 21.

Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background/purpose: Our previous study found 109 gastric parietal cell antibody (GPCA)-positive burning mouth syndrome (BMS) patients (so-called GPCABMS patients in this study) in a group of 884 BMS patients. This study evaluated whether high-titer (GPCA titer ≥ 160) GPCABMS patients had greater frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than low-titer (GPCA titer < 160) GPCABMS patients or 442 healthy control subjects.

Materials And Methods: Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 42 high-titer GPCABMS patients, 67 low-titer GPCABMS patients, and 442 healthy control subjects were measured and compared. Read More

Nutr Hosp 2022 Mar;39(2):473-478

Department of Human Nutrition and Metabolism Research. Facultad de Ciencias de la Salud. Universidad Marista de Mérida.

Introduction: Introduction: vegan diets exclude the consumption of animal-derived products, and health advantages have been reported when followed. However, heterogeneous eating habits, food availability, and sociocultural characteristics among regions could lead to different physiological results. Case reports: twelve patients following a strict vegan diet for an uninterrupted period of ≥ 3 years were subjected to clinical assessment. Read More

Hematology 2021 Dec;26(1):881-884

Oncology Division, Kaiser Permanente San Jose Medical Center, San Jose, CA, USA.

Mean corpuscular volume (MCV) as a measure of the size of red blood cells (RBCs) has been pivotal in the diagnosis and morphologic classification of anemias for over a century. Despite its ubiquitous use and time-honored diagnostic value, one essential attribute of MCV has remained under the radar. It has been long underappreciated that the size of RBC correlates with the amount of hemoglobin (Hb) that it accommodates and, therefore, is an important determining factor of the total Hb level. Read More

Int J Hematol 2022 Feb 27;115(2):255-262. Epub 2021 Oct 27.

Department of Pediatrics, KAHER'S Jawaharlal Nehru Medical College, Belagavi, India.

Glucose phosphate isomerase (GPI) deficiency is an autosomal recessive condition with mutations in the GPI gene on chromosome 19q13.1. Patients present with congenital non-spherocytic hemolytic anemia, and occasionally intellectual disability. Read More

Platelets 2021 Oct 21:1-8. Epub 2021 Oct 21.

Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.

Platelet activation in the hemodialysis (HD) circuit often causes thrombocytopenia. However, its clinical and pathophysiological significance has rarely been explored. Herein, we investigated the predictive value of thrombocytopenia for cardiovascular events (CVE) in maintenance HD patients and attempted to explore its mechanistic background considering recent knowledge of platelet dynamics. Read More

Rev Med Interne 2022 Jan 11;43(1):3-8. Epub 2021 Oct 11.

Université de. Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, 59000 Lille, France; Inserm, 59000 Lille, France; Service de médecine interne et immunologie clinique, centre de référence des maladies auto-immunes systémiques rares du Nord et Nord-Ouest de France (CeRAINO), CHU de Lille, 59000 Lille, France. Electronic address:

Introduction: Telomeres are composed of a repeated sequence of double-stranded nucleotides TTAGGG and numerous proteins including the Shelterin complex. Their main role is to maintain the stability of the genome during cell replication through a mechanism of copying the repeted sequence by the telomerase complexe. All the diseases involving a deregulation of this complex are now grouped together under the term telomeropathies. Read More

Vet Clin Pathol 2021 Dec 10;50(4):501-506. Epub 2021 Oct 10.

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Background: Canine stomatocytosis is a well-recognized rare erythrocyte disorder characterized by nonsyndromic forms with selective erythroid involvement, syndromic forms with extra-hematologic disease, and acquired forms.

Objectives: We describe serial clinicopathologic changes in two dogs with stomatocytosis of breeds that are different from those previously reported.

Methods: Blood samples were obtained from a 12-year-old female neutered Australian Cattle Dog and a 12-year-old male neutered Beagle for hematologic and biochemical analyses, including a morphologic examination of peripheral blood films. Read More

J Clin Pathol 2021 Oct 7. Epub 2021 Oct 7.

OLVG Lab BV, Amsterdam, The Netherlands

Aims: Recently, a new automated digital cell imaging analyser (Sysmex CellaVision DC-1), intended for use in low-volume and small satellite laboratories, has become available. The purpose of this study was to compare the performance of the DC-1 with the Sysmex DI-60 system and the gold standard, manual microscopy.

Methods: White blood cell (WBC) differential counts in 100 normal and 100 abnormal peripheral blood smears were compared between the DC-1, the DI-60 and manual microscopy to establish accuracy, within-run imprecision, clinical sensitivity and specificity. Read More

J Blood Med 2021 16;12:839-847. Epub 2021 Sep 16.

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: The adverse health effects of chronic gasoline exposure may be related to impairment of the hematopoietic system with bone marrow suppression, an increased risk of blood cell morphology abnormality and developing cancer.

Objective: To assess the effect of gasoline exposure on hematological parameters among gas station workers in Mekelle City, Tigray Region, Northern Ethiopia.

Methods: This cross-sectional study was carried out on 43 subjects (exposed group) and 77 subjects (unexposed group) with matched age and sex. Read More

Anticancer Drugs 2022 01;33(1):e655-e661

Department of Oncology, University Hospital of Split.

The aim of this study was to explore the red blood cell changes that occur during neoadjuvant dose-dense chemotherapy (NAC) of breast cancer. Also, we investigated the role of macrocytosis as a predictive biomarker for pathological complete response and disease-free survival (DFS) in these patients. A retrospective analysis of 82 breast cancer patients' data treated with anthracycline-cyclophosphamide-paclitaxel (AC-T) NAC in three oncology institutions in south Croatia from 2013 to 2020 was carried out. Read More

J Dent Sci 2021 Oct 8;16(4):1133-1139. Epub 2021 Jun 8.

Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background/purpose: Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study evaluated whether 46 burning mouth syndrome (BMS) patients with macrocytosis had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 442 healthy control subjects or 884 BMS patients.

Materials And Methods: Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 46 BMS patients with macrocytosis, 884 BMS patients, and 442 healthy control subjects were measured and compared. Read More

J Dent Sci 2021 Oct 19;16(4):1110-1116. Epub 2021 Jun 19.

Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background/purpose: Our previous study found that 70 of 884 burning mouth syndrome (BMS) patients have serum gastric parietal cell antibody (GPCA) positivity but without thyroglobulin antibody (TGA) and thyroid microsomal antibody (TMA) (so-called GPCATGA-TMA-BMS patients). This study assessed whether these 70 GPCATGA-TMA-BMS patients had significantly higher frequencies of macrocytosis, anemia, hematinic deficiencies, and hyperhomocysteinemia than 553 GPCA-negative, TGA-negative, and TMA-negative BMS (GPCA-TGA-TMA-BMS) patients or 442 healthy control subjects.

Materials And Methods: Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, GPCA, TGA, and TMA levels in 70 GPCATGA-TMA-BMS patients, 553 GPCA-TGA-TMA-BMS patients, and 442 healthy control subjects were measured and compared. Read More

Tumori 2021 Jul 23:3008916211033905. Epub 2021 Jul 23.

Dipartimento di Medicina e Chirurgia, Università degli Studi dell'Insubria di Varese, Varese, Italy.

Background: Hemochrome parameters at the diagnosis of metastatic renal cell carcinoma (mRCC) and the development of macrocytosis during sunitinib therapy are considered prognostic.

Objective: To evaluate the prognostic role of hematologic parameters and macrocytosis in mRCC treated with sunitinib.

Methods: We analyzed clinical data of 100 patients with mRCC treated with sunitinib as first-line therapy in a retrospective multicenter study. Read More

Transl Psychiatry 2021 07 7;11(1):380. Epub 2021 Jul 7.

Centre for Addiction and Mental Health, Toronto, ON, Canada.

Prevention of major depressive disorder (MDD) is a public health priority. Identifying biomarkers of underlying biological processes that contribute to MDD onset may help address this public health need. This prospective cohort study encompassed 383,131 white British participants from the UK Biobank with no prior history of MDD, with replication in 50,759 participants of other ancestries. Read More

BMC Anesthesiol 2021 06 16;21(1):171. Epub 2021 Jun 16.

Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Megaloblastic anemia or bone marrow changes could occur after prolonged nitrous oxide inhalation via vitamin B inactivation related DNA synthesis impairment. Previous researches have studied hematological changes with nitrous oxide exposure, but only in adults or adolescents. Pre-school age children with active hematopoietic red bone marrow are more vulnerable to potential side effects of nitrous oxide and might experience growth impairment. Read More

Haematologica 2022 04 1;107(4):887-898. Epub 2022 Apr 1.

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, USA; Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.

Tatton-Brown-Rahman syndrome (TBRS) is an overgrowth disorder caused by germline heterozygous mutations in the DNA methyltransferase DNMT3A. DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations are frequent in hematologic malignancies and clonal hematopoiesis. Yet, the impact of constitutive DNMT3A mutation on hematopoiesis in TBRS is undefined. Read More

Comb Chem High Throughput Screen 2021 May 28. Epub 2021 May 28.

Department of Emergency Medicine, Harran University Medicine Faculty, Sanliurfa, Turkey.

Background: There is a possible relation between red blood cell distribution width (RDW) and various clinical conditions. These conditions can render RDW disadvantageous in its relation with cardiovascular disease. There may be a relation between the severity of acute coronary syndrome (ACS) and the percentage of hypochromia (hypo%), percentage of hyperchromia (hyper%), percentage of macrocytosis (MAC%), and percentage of microcytosis (MIC%) values measured using new-generation hematological devices. Read More

Diabetes Metab Syndr Obes 2021 3;14:2011-2018. Epub 2021 May 3.

Department of Biochemistry, School of Medicine, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.

Background: Metformin is the first-line drug in the treatment of type 2 diabetes mellitus. Monitoring vitamin B deficiency associated with long-term and high-dose therapy is not a common practice in many clinical settings in Ethiopia.

Objective: The study aimed to measure levels of serum vitamin B and folate and to assess the macrocytic status of type 2 diabetes mellitus patients on metformin. Read More

Ann Cardiol Angeiol (Paris) 2021 Jun 4;70(3):177-182. Epub 2021 May 4.

Service de médecine vasculaire, CHU de Caen, Caen, France. Electronic address:

Introduction: Venous thromboembolic diseases have an incidence of 1.57/1000. Among patients under 50 years old, thrombophilia is assessed, the indications for which are increasingly stringent. Read More

Ann Clin Lab Sci 2021 Mar;51(2):213-219

Department of Clinical Laboratory Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan.

Objective: Patients with warm autoimmune hemolytic anemia (WAIHA) present with anemia that is highly heterogeneous, and often have macrocytic anemia with inappropriately elevated mean corpuscular volume (MCV). The goal of this retrospectivecase study is to elucidate the characteristics of anemia in patients with idiopathic WAIHA.

Procedures: The hematological parameters were analyzed by automated hematology analyzers in 19 consecutive patients with idiopathic WAIHA. Read More