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Eur J Ophthalmol 2022 May 17:11206721221102258. Epub 2022 May 17.

Department of Vitreo-retinal Services, 29954Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India.

Aim: To report the outcomes of the "inverse drainage Nd:YAG laser membranotomy" technique for the management of pre-macular hemorrhage (PMH), which has its inferior margin near the fovea.

Methods: This retrospective study included eyes with PMH, with its inferior margin located within 0.5 disc-diameter (DD) of the fovea. Read More

Cureus 2022 Apr 7;14(4):e23903. Epub 2022 Apr 7.

Ophthalmology, Primary Health Care Corporation, Doha, QAT.

Retinal arterial macroaneurysms represent an acquired vascular irregularity that is primarily observed in the elderly population. The high variability surrounding the clinical presentation of this condition makes the initial diagnosis challenging. Employing several diagnostic techniques including fundus fluorescence angiography, optical coherence tomography, and optical coherence tomography angiography ensures that any hemorrhages secondary to macroaneurysms rupture are identified promptly. Read More

Am J Ophthalmol Case Rep 2022 Jun 29;26:101548. Epub 2022 Apr 29.

Critical Care Services Administration, King Fahad Medical City, Riyadh, Saudi Arabia.

Purpose: Familial retinal arterial macroaneurysm (FRAM) is a rare genetic disorder caused by a gene mutation in the insulin-like growth factor binding protein 7 (IGFBP7).

Observations: We report a 30-year-old male with FRAM and IGFBP7 gene mutation who presented with an acute coronary syndrome (ACS). Invasive coronary angiography revealed a large aneurysm at the proximal part of the left anterior descending (LAD) artery. Read More

Indian J Ophthalmol 2022 05;70(5):1865

Department of Ophthalmology, Tung Wah Eastern Hospital, Hong Kong.

BMJ Case Rep 2022 Apr 20;15(4). Epub 2022 Apr 20.

Aravind Eye Hospital, Madurai, India.

Congenital retinal macrovessel (CRM) is defined as a large aberrant blood vessel that traverses through the central macula. It can have large tributaries extending on both sides of the horizontal raphe. The condition is typically asymptomatic. Read More

Clin Case Rep 2022 Apr 5;10(4):e05683. Epub 2022 Apr 5.

Department of Ophthalmology Tsukazaki Hospital Himeji Japan.

Retinal arterial macroaneurysm shows rapid vision loss when rupture occurs; therefore, preventive photocoagulation should be considered, if necessary. Read More

Int Med Case Rep J 2022 5;15:141-155. Epub 2022 Apr 5.

Department of Ophthalmology, University of Calabar Teaching Hospital, Calabar, Nigeria.

Purpose: To report incidence, clinical presentation, and treatment outcome of full-thickness macular hole (FTMHs) diagnosed post pars plana vitrectomy.

Methods: We retrospectively reviewed the demographics, best-corrected visual acuity (BCVA), indication for the primary vitrectomy, time to diagnose the secondary FTMH, optical coherence tomographic (OCT) appearance, and treatment outcome of FTMHs, occurring after vitrectomy performed between January 2019 and December 2020.

Results: Six of 523 vitrectomized eyes developed FTMHs, an incidence of 1. Read More

Eur Heart J Case Rep 2022 Feb 9;6(2):ytac057. Epub 2022 Feb 9.

King Fahad Medical City, Dabab Street, Sulaimaniya, PO Box 221124, 11311 Riyadh, Saudi Arabia.

Background: The term 'Giant' coronary aneurysm is usually defined as any coronary aneurysm more than 8 mm in maximum diameter. The form of familial retinal arterial macroaneurysms (FRAMs) is a rare autosomal recessive disease that is described by arterial aneurysm formation in the retina. Here, we report an association of coronary artery aneurysms with FRAM in a young male who presented with the acute coronary syndrome. Read More

Am J Ophthalmol Case Rep 2022 Jun 26;26:101458. Epub 2022 Feb 26.

Department of Ophthalmology, Hôpital Intercommunal de Créteil, Université Paris Est, Créteil, France.

Purpose: To report the uncommon rupture of a macular macroaneurysm (MAR) during navigated retinal laser (Navilas®) focal treatment in a patient with adult onset Coats disease.

Observation: A 30-year-old man consulted for progressive decrease of vision in his right eye from one week. Fundoscopy examination showed macular hard exudates, aneurysms, vascular telangiectasias in the temporal inferior quadrant consistent with an adult onset Coats disease (CD). Read More

Am J Ophthalmol Case Rep 2022 Mar 26;25:101346. Epub 2022 Jan 26.

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shougoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Purpose: To highlight a potential pathogenetic mechanism of retinal arterial macroaneurysm.

Observations: A 79-year-old woman presented with a ruptured retinal arterial macroaneurysm in the right eye. One year after treatment, high-resolution multimodal imaging with optical coherence tomography (OCT), OCT angiography, and adaptive optics scanning light ophthalmoscope showed that a narrow passage developed in the vessel wall of the pre-existing retinal arterial macroaneurysm and another macroaneurysm had developed adjacent to the pre-existing one. Read More

J Fr Ophtalmol 2022 04 29;45(4):488-489. Epub 2022 Jan 29.

Service d'ophtalmologie, hôpital Bretonneau, centre hospitalier universitaire régional, 2, boulevard Tonnellé, 37044 Tours, France. Electronic address:

Ophthalmologe 2022 Mar 14;119(3):309-326. Epub 2022 Jan 14.

Universitäts-Augenklinik, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30652, Hannover, Deutschland.

Intravitreal injection (IVI) of drugs for treatment of various macular diseases is now one of the most frequently performed surgical procedures worldwide. As mostly chronic diseases are treated, the indications for treatment often mean a continuous treatment over years with a corresponding effort regarding spatial, personnel and financial resources. The diagnosis and indications for treatment are nowadays mainly made by spectral domain optical coherence tomography (SD-OCT). Read More

Sci Rep 2022 01 11;12(1):503. Epub 2022 Jan 11.

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, 606-8507, Japan.

The aim of this retrospective, observational study was to examine the intraretinal locations of ruptured retinal arterial macroaneurysms (RMAs) and investigate the associations with the visual prognosis. Fifty patients (50 eyes) with untreated RMA rupture who visited the Department of Ophthalmology at Kyoto University Hospital (April 2014-July 2019) were included. The intraretinal position of the ruptured RMAs relative to the affected retinal artery was examined using optical coherence tomography (OCT) and color fundus photography (CFP). Read More

Beyoglu Eye J 2021 10;6(1):49-53. Epub 2021 Feb 10.

Department of Ophthalmology, Etiler World Eye Hospital, Istanbul, Turkey.

Objectives: This study was designed to evaluate the reliability of preoperative ultrasonography (USG) to detect tractional retinal detachment (TRD) in vitreous hemorrhage (VH) due to proliferative diabetic retinopathy.

Methods: The medical records of patients with VH who underwent A- and B-scan ultrasonography prior to a vitrectomy between November 2016 and May 2017 were reviewed in this retrospective study. All of the patients were assessed using USG before surgery with 4-quadrant transverse and 1-quadrant longitudinal scans whether to determine if the VH was accompanied by TRD. Read More

Front Med (Lausanne) 2021 24;8:793054. Epub 2021 Dec 24.

First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.

This study aimed to report a case of vitrectomy with peeling the internal limiting membrane for the treatment of macular hole (MH) following ruptured retinal arterial macroaneurysm (RAMA). A 65-year-old woman noticed a sudden decrease in vision in the left eye. She had no other ocular problems apart from a mild cataract in both eyes before. Read More

J Ophthalmol 2021 30;2021:3160963. Epub 2021 Dec 30.

Department of Ophthalmology, UZ Leuven, Herestraat 49, Leuven 3000, Belgium.

Purpose: To determine the efficacy and safety of 23G transconjunctival sutureless vitrectomy, subretinal injection of tissue plasminogen activator using the EVA Surgical System, and pneumatic displacement with air to treat submacular hemorrhages.

Methods: Retrospective analysis of 93 eyes surgically treated for submacular hemorrhage caused by neovascular AMD or retinal macroaneurysms. . Read More

J Fr Ophtalmol 2022 Feb 6;45(2):251-252. Epub 2022 Jan 6.

Service d'ophtalmologie, CHU Bicêtre, université Paris-Saclay, réseau OPHTARA : maladies rares en ophtalmologie, 78, rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, France. Electronic address:

J Clin Med 2021 Dec 10;10(24). Epub 2021 Dec 10.

Department of Ophthalmology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Université de Paris, 75010 Paris, France.

Objective: The study aimed to determine the outcomes and prognostic factors of vitrectomy, subretinal injection of tissue-plasminogen activator and gas tamponade in macular hemorrhage (MaH) due to age-related macular degeneration (AMD) or retinal arterial macroaneurysm (RAM).

Methods: The study design utilized a multicentric retrospective case series design of consecutive patients undergoing surgery between 2014 and 2019.

Results: A total of 65 eyes from 65 patients were included in the study. Read More

Indian J Ophthalmol 2021 Dec;69(12):3564-3569

Affiliated Eye Hospital of Nanjing Medical University, Nanjing, China.

Purpose: To evaluate the outcome of the combined approach between intravitreal ranibizumab (IVR) and focal laser photocoagulation (FLP) in the treatment of symptomatic retinal arterial macroaneurysm (RAM).

Methods: A total of 10 patients were included in this clinical case series report. They were diagnosed with symptomatic RAM (one eye in each) and assessed by a comprehensive ophthalmologic examination, including fluorescein angiography (FA), optical coherence tomography angiography (OCT-A), and indocyanine green angiography (ICGA). Read More

Natl Med J India 2021 May-Jun;34(3):187

Lo Ka Chow Memorial Ophthalmic Centre, Tung Wah Eastern Hospital, Causeway Bay, Hong Kong, HKSAR.

Exp Eye Res 2021 12 29;213:108810. Epub 2021 Oct 29.

Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.

Retinal arterial macroaneurysms are characterized by the acquired fusiform or saccular dilatations of the retinal artery. Angiotensin II (Ang II) is a major signal molecule of the renin-angiotensin system, which exerts a range of pathogenic actions that are relevant to retinal vascular abnormalities. We aimed to study the effect of Ang II on retinal vessels and explore its relationship with retinal aneurysmal disease. Read More

Ophthalmol Retina 2021 11;5(11):1124

Department of Ophthalmology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, Japan.

Int Ophthalmol 2022 Feb 9;42(2):497-507. Epub 2021 Oct 9.

Academic and Research Department, BP Eye Foundation, Hospital for Children, Eye, ENT, and Rehabilitation Services, Lokanthali, Madhyapur Thimi, Bhaktapur, Bagmati, Nepal.

Purpose: To find out clinical characteristics, therapeutic options, and visual outcome in symptomatic retinal artery macroaneurysm (RAMA) patients.

Method: Newly diagnosed cases of symptomatic RAMA from January 2015 to December 2019 were included. Fifteen eyes of 15 patients with mean age 62. Read More

Ophthalmic Genet 2022 Feb 14;43(1):58-63. Epub 2021 Sep 14.

Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.

Purpose: Retinal arteriolar macroaneurysms with supravalvular pulmonic stenosis (RAMSVPS) is a rare syndrome that to date has only been reported in Saudi Arabian families. All tested patients have been homozygous for a single splice variant (NM_001553.2:c. Read More

Ocul Immunol Inflamm 2021 Aug 31:1-5. Epub 2021 Aug 31.

The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, Pennsylvania, USA.

Sarcoidosis, an idiopathic systemic disorder characterized by noncaseating granulomas, is often associated with granulomatous uveitis. Anterior segment involvement can present with mutton-fat keratic precipitates, anterior chamber cell, and iris nodules. Sarcoid associated posterior uveitis may present with vitritis, retinal vasculitis, and choroidal lesions. Read More

Graefes Arch Clin Exp Ophthalmol 2022 Feb 28;260(2):439-450. Epub 2021 Aug 28.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Purpose: To estimate the clinical characteristics of retinal arterial macroaneurysms (RAM) and evaluate the prognosis of different interventions.

Methods: This study is a meta-analysis. The databases PubMed, EMBASE, and Ovid from inception to January 2021 were searched to identify the relevant studies. Read More

Case Rep Ophthalmol 2021 May-Aug;12(2):634-639. Epub 2021 Jul 16.

Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.

We report a novel case of vitreous hemorrhage associated with suspected rupture of 2-disc-diameter retinal arterial macroaneurysm on the optic disc. A 90-year-old woman presented with blurred vision (sudden onset) in her left eye. Examination of the fundus revealed acute onset vitreous hemorrhage of unknown origin without retinal detachment. Read More

Am J Ophthalmol Case Rep 2021 Sep 29;23:101182. Epub 2021 Jul 29.

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

High resolution imaging with optical coherence tomography angiography and offset pinhole adaptive optics scanning light ophthalmoscope helped us visualize the hemodynamic and structural changes in a ruptured retinal arterial macroaneurysm in a 78-year-old woman. Intravitreal injection of anti-vascular endothelial growth factor was administered to ameliorate the condition. Read More

Cureus 2021 Jul 10;13(7):e16303. Epub 2021 Jul 10.

Department of Ophthalmology, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, SAU.

Coats' disease is an idiopathic non-hereditary condition first described by Coats in 1908 as a congenital retinal telangiectatic and aneurysmal disease associated with retinal exudation. Its presentation is classically in early childhood. We report a rare case of Coats' disease that first presented during adulthood in a 35-year-old male. Read More