Search Our Scientific Publications & Authors

Korean J Ophthalmol 2020 Jun;34(3):259-261

Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Clin Exp Optom 2020 May 24. Epub 2020 May 24.

Department of Ophthalmology, Sydney Eye Hospital, Sydney, Australia.

Ophthalmic Genet 2020 May 19:1-3. Epub 2020 May 19.

Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

: To report a favorable effect of intravitreal dexamethasone implantation in Familial Retinal Arterial Macroaneurysms (FRAM).: Retrospective Case Report.: A 32-year-old male who presented with bilateral retinal macroaneurysms. Read More

Tunis Med 2020 Jan;98(1):80-84

A 45 years old patient consulted for a sudden decrease in visual acuity in the right eye. Ophthalmological examination gave visual acuity limited to luminous perceptions with a calm anterior segment, a transparent lens and at the fundus examination a dense, massive, two-level intra-retinal and retro hyaloidal pigeon nest hemorrhage with a fusiform whitish lesion on the path of the upper temporal artery. The suspected diagnosis was a complicated ruptured retinal macroaneurysm with massive retinal and retro hyaloidal hemorrhage. Read More

Am J Case Rep 2020 May 9;21:e922437. Epub 2020 May 9.

Eye Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia.

BACKGROUND We report the successful treatment of a macular hole (MH) secondary to a retinal macroaneurysm (RAMA) rupture by pars plana vitrectomy (PPV) and autologous transplantation of an internal limiting membrane (ILM) during primary surgery. CASE REPORT A 60-year-old woman presented with a sudden loss of central vision in her right eye. Fundus examination revealed a large sub-ILM hemorrhage involving the macula in her right eye. Read More

Medwave 2020 Mar 3;20(2):e7831. Epub 2020 Mar 3.

Instituto Mexicano de Oftalmología I.A.P, Querétaro, México. Universidad Nacional Autónoma de México, CDMX, México.

Introduction: Macular hemorrhages result in a sudden and profound loss of vision. The primary treatment modalities include observation, intravitreal injection of antiangiogenic drugs, neodymium-doped yttrium aluminum garnet hialoidotomy, intravitreal injection of gas with or without tissue plasminogen activator, as monotherapy or combined with surgery. In this paper, we report four cases of macular hemorrhages of different causes treated with different approaches, and we review the literature in this regard. Read More

BMJ Open Ophthalmol 2020 16;5(1):e000394. Epub 2020 Mar 16.

New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.

Objective: Fovea-involving subretinal haemorrhage is challenging to manage with uncertain visual outcomes. We reviewed outcomes of patients with fovea-involving macular haemorrhage treated with pars plana vitrectomy (PPV) and subretinal tissue plasminogen activator (tPA) with pneumatic displacement.

Methods And Analysis: This is a retrospective interventional case series. Read More

Medicine (Baltimore) 2020 Jan;99(5):e19077

Retinal arterial macroaneurysms (RAMs) develop as outpouchings of the arterial wall that is weakened by arteriosclerosis. The traditional treatment of RAMs comprises observation, focal laser photocoagulation, or surgery. Recently, intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs has been announced as an effective therapy for fovea-threatening RAMs and quickly improve visual acuity and central retinal thickness (CRT). Read More

Med Hypothesis Discov Innov Ophthalmol 2020 1;9(1):33-37. Epub 2020 Jan 1.

Department of Ophthalmology, İzmir Democracy University, İzmir, Turkey.

Though microaneurysms are the hallmark of diabetic retinopathy (DR), large aneurismal changes termed as ''macroaneurysms'' (MAs) may also occur in the course of chronic diabetic macular edema. MAs are usually accompanied by intraretinal hard exudates, fluid accumulation and retinal hemorrhages. Detection of MAs is clinically important as it implies that macular edema is usually chronic and therefore can be resistant to intravitreal anti-vascular endothelial growth factor injections. Read More

Eur J Ophthalmol 2020 Jan 7:1120672119899033. Epub 2020 Jan 7.

Vita-Salute San Raffaele University, Milan, Italy.

Our aim is to report a case of asymptomatic retinal arterial macroaneurysm in a 9-year-old female patient. She was referred to our Ophthalmology clinic for a routine ophthalmologic examination and, after the detection of a juxtafoveal saccular vascular enlargement in indirect ophthalmoscopy, underwent a multimodal imaging assessment. Optical coherence tomography-angiography and fluorescein angiography were important to determine the nature of the lesion, identified as a congenital retinal arterial macroaneurysm. Read More

Arch Soc Esp Oftalmol 2020 Feb 24;95(2):e15-e16. Epub 2019 Dec 24.

Departamento de Oftalmología, Hospital Clínico Universitario de Valencia, Valencia, España.

Indian J Ophthalmol 2020 01;68(1):200-201

Department of Vitreo Retina, Aditya Birla Sankara Nethralaya, Kolkata, West Bengal, India.

Curr Ophthalmol Rep 2019 Jun 16;7(2):73-79. Epub 2019 Apr 16.

Miami Veterans Administration Medical Center, 1201 NW 16th St, Miami, FL 33125.

Purpose Of Review: This is a comprehensive review of management options for retinal arterial macroaneurysms (RAMs). Although close observation is typically recommended for RAMs not involving or threatening the macula, other treatment modalities can be considered for exudative or hemorrhagic complications that are vision-threatening.

Recent Findings: New imaging technologies like optical coherence tomography angiography (OCT-A) have been able to detect RAMs without the need of dye injection, further elucidating our understanding of blood flow within and around them. Read More

Eur J Ophthalmol 2019 Dec 4:1120672119891667. Epub 2019 Dec 4.

Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy.

Purpose: To describe a case of retinal arterial macroaneurysm associated with macular pucker with good response to subthreshold laser treatment.

Presentation: Two-year follow-up of a patient with decreased vision in one eye for the past 6 months. Baseline best-corrected visual acuity was 20/40 in the affected eye. Read More

Am J Ophthalmol Case Rep 2019 Dec 19;16:100556. Epub 2019 Sep 19.

Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.

Purpose: To report the possible complications of intravitreal injection of tissue plasminogen activator (t-PA) for the treatment of submacular hemorrhage associated with retinal arterial macroaneurysm (RAM).

Observations: A 75-year-old man complained of a sudden diminution of visual acuity in his left eye. Fundus examination of this eye revealed rupture of a RAM (0. Read More

SAGE Open Med Case Rep 2019 8;7:2050313X19869470. Epub 2019 Aug 8.

Dr. Shroff's Charity Eye Hospital, New Delhi, India.

A 61-year-old elderly male, hypertensive patient presented to the retina clinic with sudden drop in vision in the left eye for 6 days. His best-corrected visual acuity at presentation was counting fingers close to face. Fundus examination of the left eye revealed the presence of subretinal and preretinal haemorrhage at the macula along with hypertensive retinopathy changes in both eyes. Read More

Arch Soc Esp Oftalmol 2019 Dec 17;94(12):e91-e92. Epub 2019 Jul 17.

Unidad de Gestión Clínica de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España.

Oman J Ophthalmol 2019 May-Aug;12(2):122-124

Department of Ophthalmology, Government Medical College, Srinagar, Jammu and Kashmir, India.

In this article, we present a case of retinal arterial macroaneurysm (RAM) complicating into exudative maculopathy who was successfully treated with subthreshold laser treatment (STLT). A 45-year-old Indian female was referred to our institution with diminution of vision in her left eye for 1 month with best-corrected visual acuity (BCVA) of counting fingers at 2 m in the left eye. A dilated fundus examination of the left eye revealed deposition of lipid exudates in the macular area and a reddish round vascular lesion superior to macula around two disc diameters from the center of fovea. Read More

Ophthalmol Retina 2018 11;2(11):1170

Vitreous Retina Macula Consultants of New York, New York, New York; LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York; Department of Ophthalmology, Edward S Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York; Department of Ophthalmology, New York University School of Medicine, New York, New York.

Ophthalmic Surg Lasers Imaging Retina 2019 04;50(4):e125-e127

A 67-year-old female presented with vitreous hemorrhage and sub-internal limited membrane (ILM) hemorrhage in her right eye associated with ruptured retinal arterial macroaneurysm. During pars plana vitrectomy, intraoperative optical coherence tomography aided in the diagnosis of a small macular hole previously obscured by the sub-ILM hemorrhage. Nonexpansile gas was placed followed by postoperative prone positioning, and the hole closed successfully. Read More

JAMA Ophthalmol 2019 04 11;137(4):e190247. Epub 2019 Apr 11.

Vitreous Retina Macula Consultants of New York, New York.

Indian J Ophthalmol 2019 04;67(4):556

Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India.

Jpn J Ophthalmol 2019 Mar 19;63(2):186-196. Epub 2019 Feb 19.

Department of Ophthalmology, Nihon University Hospital, 1-6 Surugadai, Kanda, Chiyodaku, Tokyo, 101-8309, Japan.

Purpose: To investigate the usefulness of anatomic site-oriented therapy for macular hemorrhage secondary to retinal arterial macroaneurysm (RAM).

Study Design: Retrospective observational study, clinical case series METHODS: Twenty-seven consecutive patients (27 eyes) with macular hemorrhage secondary to RAM were classified according to the retinal layer(s) with hemorrhage identified by optical coherence tomography into 4 types and treated differentially. Vitrectomy was conducted for subinternal limiting membrane hemorrhage (SILMH), intravitreal gas injection for subretinal hemorrhage (SRH) or intraretinal hemorrhage (IRH), and vitrectomy and intravitreal air/gas exchange for multilevel hemorrhage (at least 2 among SILMH/SRH/IRH). Read More

Retina 2020 May;40(5):989-997

Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Okayama, Japan.

Purpose: To investigate the clinical course of submacular hemorrhage associated with ruptured retinal arterial macroaneurysm using swept-source optical coherence tomography.

Methods: This study included 23 eyes of 23 consecutive patients diagnosed with submacular hemorrhage associated with ruptured retinal arterial macroaneurysm. Cases underwent displacement of submacular hemorrhage (vitrectomy + subretinal injection of tissue plasminogen activator + air tamponade) and were followed up for 6 months after surgery. Read More

BMC Ophthalmol 2019 Jan 15;19(1):18. Epub 2019 Jan 15.

Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, 197 Ruijin Er Road, Shanghai, 200025, China.

Background: There is no consensus for the standard treatment of retinal arterial macroaneurysm (RAM). Intravitreal anti-vascular endothelium growth factor (anti-VEGF) is an alternative treatment option for RAM. The purpose of this study is to describe the clinical efficacy of intravitreal ranibizumab or intravitreal conbercept for retinal arterial macroaneurysm. Read More

Ophthalmol Retina 2018 Jul 15;2(7):694-702. Epub 2017 Dec 15.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

Objective: To characterize features of extra-vascular optical coherence tomography angiography (OCTA) signals corresponding to hyperreflective intraretinal fluid across various exudative maculopathies.

Design: Multicenter, retrospective, observational study.

Participants: Eyes with various forms of exudative maculopathy including diabetic retinopathy (DR), retinal vein occlusion (RVO), and neovascular-age related macular degeneration (nvAMD). Read More

Int J Retina Vitreous 2018 22;4:28. Epub 2018 Aug 22.

2Smt. Kanuri Santhamma Retina Vitreous Centre, L.V. Prasad Eye Institute, Kallam Anji Reddy Campus, Banjara Hills, Hyderabad, 500 034 India.

Objectives: To compare the efficacy and safety of conventional and navigated laser photocoagulation as the primary treatment option for retinal arteriolar macroaneurysm (RAM).

Methods: Eleven (9 male and 2 females, mean age 65.1 ± 12. Read More

Indian J Ophthalmol 2018 09;66(9):1352-1354

Department of Vitreoretina and Ocular Oncology, Sankara Eye Hospital, Bengaluru, Karnataka, India.

We present a rare case of retinal racemose angioma complicated with fleeting macroaneurysm (MA). A 50-year-old female presented with diminution of vision in her right eye for 6 years. Fundus examination showed a racemose angioma with hemorrhagic MA temporal to the fovea in the right eye. Read More

Medicine (Baltimore) 2018 Jul;97(30):e11497

Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun.

Rationale: Neurofibromatosis type I (NF-1) is a multisystem autosomal dominant disease characterized by pigmentation and the growth of tumors along nerves in the skin, brain, and other parts of the body. It is caused by a mutation in the NF-1 tumor suppressor gene. NF-1 vascular disease is an important complication of the disease. Read More

Lasers Med Sci 2019 Mar 19;34(2):427-430. Epub 2018 Jul 19.

Beyoglu Eye Training and Research Hospital, The University of Health Sciences, İstanbul, Turkey.

Macular telangiectasia type 2 (Mac Tel 2) is a bilateral disease of unknown cause with characteristic changes of the retinal vasculature. To the best of our knowledge, we could not find any reported cases of Mac Tel 2 with retinal arterial macroaneurysm (RAM). Our aim is to report a case of Mac Tel 2 with RAM. Read More

Am J Ophthalmol Case Rep 2018 Sep 21;11:98-100. Epub 2018 Jun 21.

L V Prasad Eye Institute, KAR Campus, Hyderabad, India.

Purpose: To describe a rare case of retinal racemose hemangioma (RRH) with retinal artery macroaneurysm (RAM) and its optical coherence tomography angiography (OCT-A) finding before and after treatment.

Observations: Congenital arteriovenous (AV) communications or RRH is a rare developmental anomaly associated with various ocular conditions. RRH alone is usually asymptomatic, and vision loss occurs when associated with other ocular complications like retinal vein occlusion, hemmorage, macular edema and macroaneurysm. Read More

Lasers Med Sci 2019 Feb 26;34(1):235-238. Epub 2018 May 26.

Beyoglu Eye Training and Research Hospital, The University of Health Sciences, İstanbul, Turkey.

Macular telangiectasia type 2 (Mac Tel 2) is a bilateral disease of unknown cause with characteristic changes of the retinal vasculature. To the best of our knowledge, we could not find any reported cases of Mac Tel 2 with retinal arterial macroaneurysm (RAM). Our aim is to report a case of Mac Tel 2 with RAM. Read More

Am J Ophthalmol Case Rep 2018 Jun 5;10:279-281. Epub 2018 Apr 5.

University of Michigan, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, United States.

Purpose: We present fundus and spectral domain optical coherence tomography findings of a patient with an arterial macroaneurysm of the optic disc.

Observations: An 87-year-old woman presented with blurry vision and was found to have a retinal arterial macroaneurysm on the optic disc. Spectral domain optical coherence tomography revealed abnormal saccular arterial dilatation on the disc with an elongation anteriorly and superficial prepapillary hemorrhages. Read More

Retin Cases Brief Rep 2018 Apr 24. Epub 2018 Apr 24.

Department of Ophthalmology, Intercity Hospital and University Paris Est, Créteil, France.

Purpose: To describe optical coherence tomography angiography (OCTA) findings in retinal arterial macroaneurysm (RAM) associated with macular edema and to correlate OCTA findings with conventional multimodal imaging.

Methods: The clinical course, conventional multimodal imaging findings including fundus color photography, spectral domain optical coherence tomography (Spectralis; Heidelberg Engineering, Heidelberg, Germany), fluorescein angiography (Heidelberg Engineering), and OCTA (Optovue, Inc, Freemont, CA) findings at baseline and during the follow-up of two eyes (two patients) with symptomatic RAM associated with macular edema were documented.

Results: Two eyes of 2 patients, both women, aged 82 and 46 years, which presented with progressive visual decline, were included. Read More

Case Rep Ophthalmol Med 2018 6;2018:5474903. Epub 2018 Mar 6.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

A case of retinal arterial macroaneurysm (RAM) is presented with multimodal imaging, including commercially available optical coherence tomography angiography (OCT-A). Following treatment with intravitreal bevacizumab, reduction of flow signal through the RAM is documented. OCT-A provides useful information for the diagnosis and management of at least some patients with RAM, without the need for traditional fluorescein angiography. Read More

Case Rep Ophthalmol 2018 Jan-Apr;9(1):113-119. Epub 2018 Feb 1.

Department of Ophthalmology, Mahoshi Hospital, Kobe, Japan.

Purpose: To report a case of macular hole (MH) secondary to a retinal arterial macroaneurysm (RAMA) which was successfully treated with an autologous transplantation of internal limiting membrane (ILM).

Case Report: An 87-year-old female presented with a sudden decrease in central vision in the right eye. A fundus examination revealed a RAMA in the superonasal macular region, a subretinal hemorrhage (SRH), involving the macula, and a sub-ILM hemorrhage. Read More

Ophthalmologe 2018 Dec;115(12):1059-1065

Augenklinik Tausendfensterhaus, Ruhrorter Str. 187, 47119, Duisburg-Ruhrort, Deutschland.

Acute premacular bleeding is often associated with vasoproliferative retinal changes, vascular anomalies or a Valsalva maneuver. The diagnosis is made during the funduscopic examination and can if necessary be confirmed with optical coherence tomography (OCT). This article presents a case example with a sub-inner limiting membrane (ILM)/sub-hyaloidal bleeding. Read More

Retina 2019 Jun;39(6):1133-1141

Department of Vitreoretinal Diseases, L. V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India.

Purpose: There is no established therapy for exudative-hemorrhagic complications in primary retinal arteriolar macroaneurysm (RAM).

Methods: Retrospective multicenter interventional study of anti-vascular endothelial growth factor in symptomatic RAMs. Central macular thickness in μm and best-corrected visual acuity in logMar were correlated with the RAM size and distance to the macula. Read More

Retina 2019 Oct;39 Suppl 1:S84-S86

Machida Hospital, Kochi, Japan.

Semergen 2018 May - Jun;44(4):288-290. Epub 2018 Feb 13.

Servicio de Oftalmología, Hospital Clínico Universitario de Valencia, Valencia, España.

Arch Soc Esp Oftalmol 2018 Oct 15;93(10):e68. Epub 2018 Feb 15.

Servicio de Oftalmología, Hospital Universitario Fundación Alcorcón, Universidad Rey Juan Carlos, Alcorcón, Madrid, España.

Case Rep Ophthalmol 2017 Sep-Dec;8(3):503-509. Epub 2017 Oct 26.

University of Illinois College of Medicine, Peoria Campus, Peoria, Illinois, USA.

Objective: To report a case of recurrent vitreous hemorrhage from an optic nerve retinal arterial macroaneurysm (ONRAM) successfully treated with intraoperative endolaser.

Patient And Methods: A 92-year-old woman on oral aspirin and warfarin anticoagulation for atrial fibrillation developed three episodes of dense vitreous hemorrhage from an ONRAM. Due to failure of the vitreous hemorrhage to clear spontaneously, a total of three pars plana vitrectomy (PPV) procedures were performed along with a 1. Read More

Case Rep Ophthalmol Med 2017 4;2017:4630187. Epub 2017 Oct 4.

Sanliurfa Education and Research Hospital, Sanliurfa, Turkey.

A 55-year-old man presented with sudden deterioration of vision in the right eye. His visual acuity was reduced to hand motion because of a large multilevel premacular hemorrhage. Nd:YAG laser was performed to drain the entrapped hemorrhage under the internal limiting membrane (ILM) and posterior hyaloid face in the macula into the vitreous. Read More

Case Rep Ophthalmol 2017 May-Aug;8(2):390-395. Epub 2017 Jul 24.

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.

Purpose: The aim of this report was to describe multimodal ocular imaging findings in a patient who presented with a ruptured retinal arterial macroaneurysm (RAM) associated with toxoplasmic Kyrieleis arteriolitis.

Methods: We report the case of a 64-year-old man with a history of systemic hypertension and dense amblyopia of the left eye who presented with decreased vision and new floaters in the left eye. Color fundus photography, spectral-domain optical coherence tomography, fluorescein angiography, and indocyanine green angiography were used as diagnostic imaging tools. Read More

Asia Pac J Ophthalmol (Phila) 2017 Sep-Oct;6(5):444-449. Epub 2017 Aug 22.

Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

Purpose: To describe the efficacy of laser and intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents for patients with symptomatic retinal arterial macroaneurysm (RAM).

Design: From 2009 to 2016, we collected patients with exudative or hemorrhagic RAM all treated by focal laser photocoagulation.

Methods: Nd:YAG laser was performed in patients with subinternal limiting membrane (sub-ILM) hemorrhage. Read More

Retin Cases Brief Rep 2020 ;14(1):61-65

Vitreous Retina Macular Consultants of New York, New York, New York.

Purpose: Congenital retinal macrovessels are large aberrant retinal blood vessels that cross the horizontal raphe and can traverse the central macula. Using multimodal imaging and optical coherence tomography angiography, we describe 2 cases of congenital retinal macrovessel associated with macroaneurysms.

Methods: Two patients presented for evaluation and were found to have congenital retinal macrovessels associated with macroaneurysms. Read More

Case Rep Ophthalmol 2017 Jan-Apr;8(1):137-143. Epub 2017 Mar 7.

aAugenzentrum "Frohe Zukunft", Halle (Saale), Germany.

Introduction: Complex retinal arterial macroaneurysms (RAM) are often accompanied by hemorrhage and/or affect the macula. We evaluated the effect of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy using ranibizumab or aflibercept with or without laser photocoagulation in the treatment of macular edema due to RAM.

Methods: A case report of two patients with secondary macular edema caused by RAM is presented. Read More

Optom Vis Sci 2017 07;94(7):781-785

*MS, DNB †MBBS ‡MD Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India (all authors).

Purpose: Retinal arteriolar macroaneurysms are a common cause of vision loss in elderly patients with hypertension and cardiovascular disease. Their occurrence in the young, however, is not well known. The purpose of this article is to describe an unusual cause of retinal arteriolar macroaneurysm in a healthy young man. Read More

Retina 2018 Jan;38 Suppl 1:S114-S122

Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan.

Purpose: To evaluate the clinical features of Type 1 idiopathic macular telangiectasia (IMT) followed up for 2 years.

Methods: Forty-nine patients with unilateral Type 1 IMT were examined. Thirty-one IMT eyes were treated with direct laser photocoagulation and/or intravitreal bevacizumab; the remaining 18 eyes, with good vision or slight macular edema, were untreated. Read More

Int J Ophthalmol 2017 18;10(3):491-493. Epub 2017 Mar 18.

Department of Ophthalmology, Faculty of Medicine, Ege University, Bornova 35040, İzmir, Turkey.