31,543 results match your criteria MRSA Skin Infection in Athletes


Treatment of chronic osteomyelitis with multi-dose oritavancin: a case series and literature review.

Int J Antimicrob Agents 2018 Dec 8. Epub 2018 Dec 8.

Downtown Dublin Wound Center, Meadows Regional Medical Center, Dublin, GA, 31021, USA.

Osteomyelitis remains difficult to treat, typically requiring a prolonged course of intravenous (IV) antibiotics. The optimal route and duration of antibiotics remains ill-defined due to limited prospective clinical trials. Oritavancin is a long acting, semisynthetic, lipoglycopeptide antibiotic with rapid, concentration-dependent bactericidal activity against many Gram-positive organisms. Read More

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December 2018

Methicillin-resistant Staphylococcus aureus in urban Norway rat (Rattus norvegicus) populations: Epidemiology and the impacts of kill-trapping.

Zoonoses Public Health 2018 Dec 9. Epub 2018 Dec 9.

Canadian Wildlife Health Cooperative, Abbotsford, British Columbia, Canada.

Urban Norway rat (Rattus norvegicus) populations can carry the bacteria methicillin-resistant Staphylococcus aureus (MRSA). There are numerous knowledge gaps in the epidemiology of MRSA in these populations that limit understanding of its ecology in urban environments. For example, fecal shedding of MRSA, which may increase environmental contamination, has been reported in other species; however, it is unknown whether Norway rats carry the bacteria rectally. Read More

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December 2018

Pharmacokinetic evaluation of linezolid administered intravenously in obese patients with pneumonia.

J Antimicrob Chemother 2018 Dec 7. Epub 2018 Dec 7.

Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, Ghent, Belgium.

Objectives: Altered linezolid pharmacokinetics (PK) in obese individuals has been hypothesized in previous studies. However, specific dosing recommendations for this population are still lacking. The main goal of this study was to evaluate PK/pharmacodynamic (PKPD) target attainment when using a 600 mg intravenous q12h linezolid dose against MRSA in obese patients with pneumonia. Read More

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December 2018

Sodium nitrite potentiates antimicrobial photodynamic inactivation: possible involvement of peroxynitrate.

Photochem Photobiol Sci 2018 Dec 11. Epub 2018 Dec 11.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA. and Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA and Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

We have recently shown that a wide range of different inorganic salts can potentiate antimicrobial photodynamic inactivation (aPDI) and TiO2-mediated antimicrobial photocatalysis. Potentiation has been shown with azide, bromide, thiocyanate, selenocyanate, and most strongly, with iodide. Here we show that sodium nitrite can also potentiate broad-spectrum aPDI killing of Gram-positive MRSA and Gram-negative Escherichia coli bacteria. Read More

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December 2018

Methicillin-resistant tracking spread among health-care workers and hospitalized patients in critical wards at a university hospital, Tehran, Iran.

New Microbes New Infect 2019 Jan 16;27:29-35. Epub 2018 Nov 16.

Department of Pathobiology, School of Public Health and Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Health-care workers may serve as a reservoir for dissemination of methicillin-resistant (MRSA) to patients in hospital settings. The present study aimed to screen MRSA in nasal swabs of health-care workers and clinical specimens from patients and investigate the possible relationship between these isolates at a university hospital in Tehran, Iran. Additionally, we aimed to identify potential risk factors for MRSA colonization in health-care workers. Read More

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January 2019

Complete Genome Sequences of Canadian Epidemic Methicillin-Resistant Staphylococcus aureus Strains CMRSA3 and CMRSA6.

Microbiol Resour Announc 2018 Aug 9;7(5). Epub 2018 Aug 9.

Centre for Antimicrobial Resistance, Alberta Health Services/Calgary Laboratory Services/University of Calgary, Calgary, Alberta, Canada.

Methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 8 (CC8) sequence type 239 (ST239) represents a predominant hospital-associated MRSA sublineage present worldwide. The Canadian epidemic MRSA strains CMRSA3 and CMRSA6 are moderately virulent members of this group but are closely related to the highly virulent strain TW20. Whole-genome sequencing of CMRSA3 and CMRSA6 was conducted to identify genetic determinants associated with their virulence. Read More

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Complete Genome Sequence of a Staphylococcus aureus Sequence Type 612 Isolate from an Australian Horse.

Microbiol Resour Announc 2018 Aug 2;7(4). Epub 2018 Aug 2.

Curtin Health Innovation Research Institute and School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Western Australia, Australia.

Staphylococcus aureus is a serious pathogen of humans and animals. Multilocus sequence type 612 is dominant and highly virulent in South African hospitals but relatively uncommon elsewhere. We present the complete genome sequence of methicillin-resistant Staphylococcus aureus strain SVH7513, isolated from a horse at a veterinary clinic in New South Wales, Australia. Read More

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Synthesis and Evaluation of Troponoids as a New Class of Antibiotics.

ACS Omega 2018 Nov 8;3(11):15125-15133. Epub 2018 Nov 8.

Department of Molecular Microbiology and Immunology, The Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, Missouri 63104, United States.

Novel antibiotics are urgently needed. The troponoids [tropones, tropolones, and α-hydroxytropolones (α-HT)] can have anti-bacterial activity. We synthesized or purchased 92 troponoids and evaluated their antibacterial activities against , , and . Read More

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November 2018

Methicillin-resistant Staphylococcus aureus Meningitis as a Complication of Facial Nerve Decompression for Vertebrobasilar Dolichoectasia.

Cureus 2018 Oct 1;10(10):e3392. Epub 2018 Oct 1.

Radiology, VA Medical Center, Riviera Beach, USA.

We present a case of a 55-year-old lady with intermittent twitching of the left side of her face, involving her left eyelid and the angle of the mouth, ongoing for two years. She failed multiple trials of botulinum toxin injections as well as oral anti-spasmodic medications. The patient was diagnosed with an ectatic left vertebral artery, causing a compression of cranial nerve VII on the same side on magnetic resonance imaging (MRI) of the brain. Read More

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October 2018
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Infectious and Noninfectious Acute Pericarditis in Children: An 11-Year Experience.

Int J Pediatr 2018 8;2018:5450697. Epub 2018 Nov 8.

Division of Infectious Diseases, Children's Hospital of Michigan, Detroit, MI, USA.

Objective: The study was undertaken to determine the etiology, review management, and outcome in children diagnosed with acute pericarditis during 11 years at tertiary pediatric institution.

Methods: Retrospective chart review of children diagnosed between 2004 and 2014. Patients with postsurgical pericardial effusions were excluded. Read More

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November 2018

Reverse micelle-lipid nanocapsules: a novel strategy for drug delivery of the plectasin derivate AP138 antimicrobial peptide.

Int J Nanomedicine 2018 15;13:7565-7574. Epub 2018 Nov 15.

Micro & Nanomédecines Translationelles-MINT, UNIV Angers, INSERM U1066, CNRS UMR 6021, UBL Universite Bretagne Loire, Angers, France.

Introduction: Resistance to traditional antibiotics is an increasingly serious problem. Antimicrobial peptides (AMPs) have emerged as a new therapeutic class with great potential against infectious diseases, as they are less prone to induce resistance. Nanotechnology-based delivery strategies can improve the efficiency and stability of AMPs, particularly against proteolytic degradation. Read More

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November 2018

Antibacterial effect of ozonated water against methicillin-resistant contaminating chicken meat in Wasit Province, Iraq.

Authors:
Manal H G Kanaan

Vet World 2018 Nov 18;11(10):1445-1453. Epub 2018 Oct 18.

Department of Nursing, Technical Institute of Suwaria, Middle Technical University, Baghdad, Iraq.

Background And Aim: Methicillin-resistant (MRSA) is one of the most recognized "superbugs" and a common cause of community-associated and nosocomial infections; furthermore, when chicken meat is considered a good growth medium for to make a plausible vehicle to propagate MRSA, then this study was conducted to evaluate the efficiency of ozonated water (0.5 ppm) in the elimination or reduction of MRSA contaminating fresh and frozen chicken meat sold in local markets in the Wasit Province.

Materials And Methods: A total of 72 samples of fresh and frozen chicken meat were randomly collected from dissimilar native markets: Fresh chicken meat (n=32) and frozen chicken meat (n=40). Read More

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November 2018

Antibiotic resistance is lower in Staphylococcus aureus isolated from antibiotic-free raw meat as compared to conventional raw meat.

PLoS One 2018 10;13(12):e0206712. Epub 2018 Dec 10.

Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States of America.

The frequent use of antibiotics contributes to antibiotic resistance in bacteria, resulting in an increase in infections that are difficult to treat. Livestock are commonly administered antibiotics in their feed, but there is current interest in raising animals that are only administered antibiotics during active infections. Staphylococcus aureus (SA) is a common pathogen of both humans and livestock raised for human consumption. Read More

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December 2018

Zoonotic multidrug-resistant microorganisms among small companion animals in Germany.

PLoS One 2018 7;13(12):e0208364. Epub 2018 Dec 7.

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Antimicrobial multidrug-resistant microorganisms (MDRO) can be transmitted between companion animals and their human owners. Aim of this study was to determine the prevalence of extended spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) and Staphylococcus aureus including methicillin-resistant S. aureus (MRSA) in different companion animal species. Read More

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December 2018

Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics.

Biomaterials 2018 Nov 21;192:551-559. Epub 2018 Nov 21.

Department of Nanobiomedicine/ENT, University Medical Center of Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany. Electronic address:

Multidrug-resistant bacterial infections are a global health threat. Nanoparticles are thus investigated as novel antibacterial agents for clinical practice, including wound dressings and implants. We report that nanoparticles' bactericidal activity strongly depends on their physical binding to pathogens, including multidrug-resistant primary clinical isolates, such as Staphylococcus aureus, Klebsiella pneumoniae or Enterococcus faecalis. Read More

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November 2018

Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates.

Eur J Med Chem 2018 Nov 14;163:381-393. Epub 2018 Nov 14.

NUBAD, LLC, Greenville, SC, 29605, United States; Department of Chemistry, Clemson University, Clemson, SC, 29634, United States. Electronic address:

The development of new ligands that have comparable or enhanced therapeutic efficacy relative to current drugs is vital to the health of the global community in the short and long term. One strategy to accomplish this goal is to functionalize sites on current antimicrobials to enhance specificity and affinity while abating resistance mechanisms of infectious organisms. Herein, we report the synthesis of a series of pyrene-neomycin B (PYR-NEO) conjugates, their binding affinity to A-site RNA targets, resistance to aminoglycoside-modifying enzymes (AMEs), and antibacterial activity against a wide variety of bacterial strains of clinical relevance. Read More

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November 2018

Bacteriologic analysis of bone biopsy from diabetic foot infections within a VA patient population.

Foot (Edinb) 2018 Oct 9;38:1-3. Epub 2018 Oct 9.

California School of Podiatric Medicine, University of California, San Francisco
, United States. Electronic address:

Diabetic patients with foot infections were evaluated over a 5-year period from April 2005 to March 2010. Cultures were obtained from 92 patients after surgical debridement. All of the patients were classified as "severe" diabetic foot infections (DFIs) and PEDIS grade 4. Read More

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October 2018

Antibiotic choice and MRSA rate in children who are hospitalized for atopic dermatitis.

Ann Allergy Asthma Immunol 2018 Dec 7. Epub 2018 Dec 7.

Division of Clinical Immunology and Allergy, Children's Hospital Los Angeles; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California. Electronic address:

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December 2018

A mechanistic approach to the in-vitro resistance modulating effects of fluoxetine against meticillin resistant Staphylococcus aureus strains.

Microb Pathog 2018 Dec 7. Epub 2018 Dec 7.

School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, Brazil. Electronic address:

Emergence of methicilin resistant Staphylococcus aureus (MRSA) strains is a major cause of infirmity worldwide and has limited our therapeutic options against these pathogens. In this regard, the search for candidates with an antimicrobial activity, with a greater efficacy and a lower toxicity, is necessary. As a result, there is greater need to search for resistance modifying agents which, in combination with existing drugs, will restore the efficacy of these drugs. Read More

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December 2018

Exploring Morin as an anti-quorum sensing agent (anti-QSA) against resistant strains of Staphylococcus aureus.

Microb Pathog 2018 Dec 7. Epub 2018 Dec 7.

PG and Research Department of Botany, Arignar Anna Government College, Thiruvalluvar University, Villupuram, Tamilnadu, India. Electronic address:

Staphylococcus aureus an opportunistic pathogen, causes biofilm-associated infections like nosocomial and chronic disease, where quorum sensing plays vital role. Biofilm-associated infections are provocative due to antibiotic resistance and become major public health threat to human. Accordingly, there is an urgent need to identify novel compounds and groundbreaking methods to pervade and clear biofilm-associated infections. Read More

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December 2018

Comparison of molecular epidemiology of bloodstream methicillin-resistant Staphylococcus aureus isolates between a new and an old hospitals in central Taiwan.

Int J Infect Dis 2018 Dec 7. Epub 2018 Dec 7.

Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Objective: To compare the molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) isolates between an old, urban hospital and a new, rural hospital over the same time period.

Methods: We retrospectively analyzed molecular characteristics of 398 MRSA bloodstream isolates collected between 2007 and 2013 from two hospitals in Taiwan, 202 isolates from the old one and 196 isolates from the new one (opened in 2007).

Results: The rate of multiple antibiotics resistance was significantly higher in the old hospital (93%) than in the new hospital (81%) (p <0. Read More

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December 2018
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Validation of a novel molecular diagnostic panel for pediatric musculoskeletal infections: Integration of the cepheid Xpert MRSA/SA SSTI and laboratory-developed real-time PCR assays for clindamycin resistance genes and Kingella kingae detection.

J Microbiol Methods 2018 Dec 7. Epub 2018 Dec 7.

Division of Pediatric Infectious Diseases, Children's Hospital Colorado, 13123 East 16th Avenue, Aurora, CO 80045, USA. Electronic address:

Background: Pathogen detection in pediatric patients with musculoskeletal infections relies on conventional bacterial culture, which is slow and can delay antimicrobial optimization. The ability to rapidly identify causative agents and antimicrobial resistance genes in these infections may improve clinical care.

Methods: Convenience specimens from bone and joint samples submitted for culture to Children's Hospital Colorado (CHCO) from June 2012 to October 2016 were evaluated using a "Musculoskeletal Diagnostic Panel" (MDP) consisting of the Xpert MRSA/SA SSTI real-time PCR (qPCR, Cepheid) and laboratory-developed qPCRs for Kingella kingae detection and erm genes A, B, and C which confer clindamycin resistance. Read More

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December 2018

How often are health care personnel hands colonized with multidrug- resistant organisms? A systematic review and meta-analysis.

Am J Infect Control 2018 Dec 5. Epub 2018 Dec 5.

Division of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI; Geriatrics Research Education and Clinical Center, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI.

Background: Hands of health care personnel (HCP) can transmit multidrug-resistant organisms (MDROs), resulting in infections. Our aim was to determine MDRO prevalence on HCP hands in adult acute care and nursing facility settings.

Methods: A systematic search of PubMed/MEDLINE, Web of Science, CINAHL, Embase, and Cochrane CENTRAL was performed. Read More

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December 2018

Terminalia bellirica fruit extracts: in-vitro antibacterial activity against selected multidrug-resistant bacteria, radical scavenging activity and cytotoxicity study on BHK-21 cells.

BMC Complement Altern Med 2018 Dec 7;18(1):325. Epub 2018 Dec 7.

Department of Chemistry, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka.

Background: Identification of novel sources for developing new antibiotics is imperative with the emergence of antibiotic resistant bacteria. The fruits of Terminalia bellirica (Gaertn) Roxb., widely used in traditional medicine, were evaluated for antibacterial activity against multidrug-resistant (MDR) bacteria, antioxidant activity and cytotoxicity. Read More

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December 2018

Recombinant Staphylococcal Antigen-F (r-ScaF), a novel vaccine candidate against methicillin resistant Staphylococcus aureus infection: Potency and efficacy studies.

Microb Pathog 2018 Dec 3;127:159-165. Epub 2018 Dec 3.

Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Staphylococcus aureus is a human commensal and pathogen, its clinical importance is exacerbated by the spread of multi-drug resistant strains. The potential future failure of antibiotic therapy necessitates the development of novel control regimes, including new immunotherapeutic approaches. S. Read More

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December 2018

Staphylococcus aureus from ocular and otolaryngology infections are frequently resistant to clinically important antibiotics and are associated with lineages of community and hospital origins.

PLoS One 2018 6;13(12):e0208518. Epub 2018 Dec 6.

Infectious Diseases Institute, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America.

Staphylococcus aureus is an important human pathogen that causes serious antibiotic-resistant infections. Its population structure is marked by the appearance and dissemination of successful lineages across different settings. To begin understanding the population structure of S. Read More

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December 2018
2 Reads

Low serum trough concentrations and high vancomycin MIC in methicillin-sensitive Staphylococcus aureus from hemodialysis patients in Brazil.

Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.

Department of Pathology, Health Sciences Center, Federal University of Espírito Santo (UFES), Marechal Campos Ave., 1468, 29040-090 Vitória, Espírito Santo, Brazil.

Background: The empiric antimicrobial therapy for bacteremia of long-term hemodialysis (HD) outpatients is currently based on the combination of vancomycin and gentamicin because of the high frequency of isolated Staphylococcus species. The vancomycin trough level range from 15 to 20 µg/mL is expected for therapeutic success against methicillin-resistant S. aureus with vancomycin MIC ≥ 1. Read More

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December 2018

Septic Arthritis of the Hip-Risk Factors Associated With Secondary Surgery.

J Am Acad Orthop Surg 2018 Dec 4. Epub 2018 Dec 4.

From the Department of Orthopaedics (Dr. R. F. Murphy, Dr. Plumblee, Dr. Barfield, and Dr. Dow), Medical University of South Carolina, Charleston SC, Children's Orthopaedics of Atlanta, Atlanta, GA (Dr. J. S. Murphy, Mr. Fuerstenau), the Department of Orthopaedics and Biomedical Engineering, University of Tennessee-Campbell Clinic, Memphis, TN (Dr. Spence and Dr. Kelly), and Shriner's Hospital for Children, Springfield, MA (Dr. Mooney).

Introduction: Septic arthritis of the hip (SAH) is a common condition encountered by pediatric orthopaedic surgeons and is treated with arthrotomy and irrigation. Depending on the response to initial treatment, some patients require surgical treatment beyond the index procedure. The purpose of this study was to investigate risk factors for repeat surgical intervention after initial arthrotomy for presumed SAH. Read More

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December 2018
5 Reads

Bacterial detection and identification from human synovial fluids on an integrated microfluidic system.

Analyst 2018 Dec 6. Epub 2018 Dec 6.

Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan. and Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan and Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan.

Periprosthetic joint infections (PJIs) are among the most severe complications emerging from prosthetic joint replacement surgeries. In order to possess a rapid means of diagnosing PJIs, an integrated microfluidic system was developed herein for detecting and identifying bacteria in human synovial fluid (HSF). The entire molecular diagnostic process, including (1) sample treatment, (2) bacterial isolation, (3) bacterial lysis, (4) nucleic acid amplification (via polymerase chain reaction (PCR)), and (5) optical detection, could be automated on a single chip. Read More

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December 2018
1 Read

Costs of outpatient and inpatient MRSA screening and treatment strategies for patients at elective hospital admission - a decision tree analysis.

Antimicrob Resist Infect Control 2018 29;7:147. Epub 2018 Nov 29.

2Institute of Hygiene and Environmental Health, University Medicine of Greifswald, Walther-Rathenau-Straße 49a, 17489 Greifswald, Germany.

Background: Nosocomial infections are among the most common complications in hospitals. A major part is caused by multidrug-resistant organisms (MDRO). MRSA is still the most prominent and frequent MDRO. Read More

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November 2018

Distribution and drug resistance of pathogenic bacteria in ventilator-associated pneumonia at a local hospital of North-eastern China.

Infect Drug Resist 2018 13;11:2249-2255. Epub 2018 Nov 13.

Department of Emergency, Shengjing Hospital Affiliated to China Medical University, Heping District, Shenyang, Liaoning Province 110004, People's Republic of China,

Purpose: To study the distribution of pathogenic bacteria in ventilator-associated pneumonia (VAP), and epidemiological characteristics of extended-spectrum β lactamase (ESBL)-producing bacteria.

Patients And Methods: Lower respiratory tract secretions from 156 patients with mechanical ventilation were collected using a protective specimen brush (PSB), with quantitative bacterial culture carried out and antibiotic sensitivity measured. ESBLs produced by Gram-negative bacilli were detected using the double disk diffusion method and monitored by plasmid profiles. Read More

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November 2018

A review on nanosystems as an effective approach against infections of .

Int J Nanomedicine 2018 9;13:7333-7347. Epub 2018 Nov 9.

MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, China,

() is an important zoonotic bacteria and hazardous for the health of human beings and livestock globally. The characteristics like biofilm forming, facultative intracellular survival, and growing resistance of pose a great challenge to its use in therapy. Nanoparticles are considered as a promising way to overcome the infections' therapeutic problems caused by . Read More

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November 2018
2 Reads

USA300 Staphylococcus aureus persists on multiple body sites following an infection.

BMC Microbiol 2018 Dec 5;18(1):206. Epub 2018 Dec 5.

Department of Medicine, Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA, USA.

Background: USA300 methicillin-resistant Staphylococcus aureus (MRSA) is a community- and hospital-acquired pathogen that frequently causes infections but also can survive on the human body asymptomatically as a part of the normal microbiota. We devised a comparative genomic strategy to track colonizing USA300 at different body sites after an initial infection. We sampled ST8 S. Read More

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December 2018

Post Dengue Fever Epidural Abscess With or Without Spondylodiscitis: A Case Series of Eight Patients in a Single Season in a Single Center: Does the Dengue Have a Predilection for the Neural Tissue?

Spine (Phila Pa 1976) 2018 Dec;43(24):E1454-E1462

Aster MIMS Hospital, Calicut, Kerala, India.

Study Design: A retrospective case series.

Objective: The aim of this study was to report the immunosuppression and secondary bacterial infection after dengue viral infection and the predilection of these infections in the spine. This can trigger further research in to this fact. Read More

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December 2018
1 Read

Nasal septal abscess: a 10-year retrospective study.

Eur Arch Otorhinolaryngol 2018 Nov 30. Epub 2018 Nov 30.

Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road Section 2, Taipei 114, Taiwan, ROC.

Objective: Nasal septal abscess is an uncommon condition but it can cause potentially life-threatening intracranial complications and cosmetic nasal deformity.

Methods: We analyzed ten years of cases to determine the optimal diagnostic and therapeutic modalities. A retrospective review of case notes from Tri-Service General Hospital archives was performed. Read More

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November 2018
3 Reads

Safety of Temporary Use of Recycled Autoclaved Femoral Components in Infected Total Knee Arthroplasty: Confirming Sterility Using a Sonication Method.

Clin Orthop Surg 2018 Dec 21;10(4):427-432. Epub 2018 Nov 21.

Department of Orthopaedic Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea.

Background: The purpose of this study was to evaluate the usefulness of sonication technique for microbiological diagnosis and the sterility of the recycled autoclaved femoral components from infected total knee arthroplasty (TKA) using a sonication method.

Methods: Nineteen femoral implants explanted from patients with infected TKA were sterilized with a standard autoclave method. Standard culture of the fluid before and after sonication of the sterilized implants was performed to detect pathogenic microorganisms. Read More

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December 2018
1 Read

Prevalence and Characterization of Isolated From Women and Children in Guangzhou, China.

Front Microbiol 2018 16;9:2790. Epub 2018 Nov 16.

Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

The prevalent clones and antibiotic susceptibility profiles are known to change dynamically and geographically; however, recent strains causing infections in women and children in China have not been characterized. In this study, we analyzed the molecular epidemiology and antimicrobial resistance of isolated from patients in four centers for women and children in Guangzhou, China. In total, 131 isolates (100 from children and 31 from women) were analyzed by spa typing, multi-locus sequence typing, virulence gene and antimicrobial resistance profiling, staphylococcal chromosomal cassette typing, and mutation analyses of . Read More

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November 2018
3 Reads

Floral markers and biological activity of Saudi honey.

Saudi J Biol Sci 2018 Nov 29;25(7):1369-1374. Epub 2018 May 29.

Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

The objectives of this research were to identify certain chemical compounds that may be used as fingerprints of Saudi honey and to evaluate their antioxidant and antibacterial activities. Eleven Saudi 'monofloral' honey samples were analyzed and evaluated. Non-phenolic compounds, such as 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, methyl 3-hydroxyhexanaote and 5-hydroxymethyl-2-furancarboxaldehyde were present in different types of tested honey samples. Read More

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November 2018

[Design, Synthesis and Structure-activity Relationship Study of a Series of Bis(bibenzyl)-type Natural Products, Riccardin C Derivatives, as Candidate Anti-MRSA Agents].

Yakugaku Zasshi 2018 ;138(12):1537-1547

Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.

We previously showed that a naturally occurring macrocyclic bis(bibenzyl) derivative, riccardin C (RC), exhibits antibacterial activity towards methicillin-resistant Staphylococcus aureus (MRSA), with a potency comparable to that of the clinically used drug vancomycin. Here, we synthesized a series of RC derivatives to explore the structure-activity relationships (SAR). The SAR results clearly indicated that the number and positions of the phenolic hydroxyl groups are primary determinants of the anti-MRSA activity. Read More

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January 2018

Emergency medical services oxygen equipment: a fomite for transmission of MRSA?

Emerg Med J 2018 Dec 1. Epub 2018 Dec 1.

Objectives: The primary purpose of this study was to determine if methicillin-resistant (MRSA) was present on the surface of oxygen cylinders and regulators used in the prehospital setting and secondarily to assess other surfaces for MRSA within the ambulance compartment, as a comparison.

Methods: On 17 March 2018, the surface of oxygen cylinders and regulators located in ambulances at an emergency medical services (EMS) station in North Alabama (n=9) and at an offsite oxygen cylinder storage area (n=70) were swabbed using sterile cotton-tipped applicators saturated in an 0.9% NaCl solution. Read More

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December 2018

The antimicrobial activity of chemerin-derived peptide p4 requires oxidative conditions.

J Biol Chem 2018 Nov 30. Epub 2018 Nov 30.

Immunology, Faculty of Biochemistry, Biophysics & Biotechnology, Jagiellonian University, Poland.

Chemerin is a leukocyte attractant, adipokine, and antimicrobial protein abundantly produced in the skin epidermis. Despite the fact that most of the bactericidal activity present in human skin exudates is chemerin-dependent, just how chemerin shapes skin defenses remains obscure. Here, we demonstrate that p4, a potent antimicrobial human chemerin peptide derivative, displays killing activity against pathogenic methicillin-resistant Staphylococcus aureus (MRSA) strains and suppresses microbial growth in a topical skin infection model. Read More

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November 2018
1 Read

New approach to address antibiotic resistance: Miss loading of functional membrane microdomains (FMM) of methicillin-resistant Staphylococcus aureus (MRSA).

Microb Pathog 2018 Nov 29;127:106-115. Epub 2018 Nov 29.

Department of Chemistry, Sri Jayachamarajendra College of Engineering, JSS Science and Technology University, Mysuru, 570 006, Karnataka, India. Electronic address:

The synthesized potent piperazine analog ChDiPiCa was characterised by various spectroscopic techniques and for the first time evaluated functional membrane microdomain (FMM) disassembly in methicillin-resistant Staphylococcus aureus (MRSA). The ChDiPiCa showed excellent in vitro biocidal activity against MRSA at 26 μg/mL compared to the antibiotic streptomycin and bacitracin 14 μg/mL and 13 μg/mL at 10 μg concentration respectively. The membrane damaging property was confirmed by the SEM analysis. Read More

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November 2018
1 Read

Interplay of personal, pet, and environmental colonization in households affected by community-associated methicillin-resistant Staphylococcus aureus.

J Infect 2018 Nov 29. Epub 2018 Nov 29.

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

Objective: We sought to determine the prevalence, molecular epidemiology, and factors associated with Staphylococcus aureus environmental surface and pet colonization in households of children with community-associated methicillin-resistant S. aureus (CA-MRSA) infection.

Methods: Between 2012 and 2015, 150 children with CA-MRSA infections and their household contacts and pets were enrolled in this cross-sectional study in metropolitan Saint Louis, MO. Read More

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November 2018

Comparison of USA300 with non-USA300 methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit.

Int J Infect Dis 2018 Nov 29. Epub 2018 Nov 29.

Division of Infectious Diseases, Department of Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

Objectives: Reports of USA300 methicillin-resistant Staphylococcus aureus (MRSA) strain were still scarce in neonatal intensive care units (NICUs) and relationship of USA300 MRSA to clinical infections is still controversial. Primary outcome was the incidence of MRSA infections caused by the USA300 and non-USA300 strains at a NICU in Japan.

Methods: This retrospective cohort study was conducted between November 2011 and October 2016 at Tokyo Metropolitan Children's Medical Center in Japan. Read More

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November 2018

Synthesis and characterization of pyridoxine, nicotine and nicotinamide salts of dithiophosphoric acids as antibacterial agents against resistant wound infection.

Bioorg Med Chem 2018 Nov 13. Epub 2018 Nov 13.

Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, 18 Kremlyovskaya St., Russia. Electronic address:

The pyridine-derived biomolecules are of considerable interest in developing medicinal compounds with various specific activities. Novel ammonium salts of pyridoxine, (S)-(-)-nicotine and nicotinamide with O,O-diorganyl dithiophosphoric acids (DTPA) were synthesized and characterized. The complexation of chiral monoterpenyl DTPA, including (S)-(-)-menthyl, (R)-(+)-menthyl, (1R)-endo-(+)-fenchyl, (1S,2S,3S,5R)-(+)-isopinocampheolyl derivatives, with pyridoxine and nicotine provided effective antibacterial compounds 3a,b,e,f, and 5a,b,d,f with MIC values against Gram-positive bacteria as low as 10 µM (6 µg/mL). Read More

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November 2018

Relationship between nasal Carrier isolates and clinical isolates in children with Staphylococcus aureus infections.

Microb Pathog 2018 Nov 28. Epub 2018 Nov 28.

Department of Pediatrics, West China Second Hospital, Sichuan University and Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, No. 20, 3rd Section of Renmin South Road, Chengdu, 610041, China. Electronic address:

Aim: To assess the relationship between Staphylococcus aureus (S. aureus) strains colonizing the anterior nares and clinical isolate colonizing other, non-nasal infectious sites in children with S. aureus infections. Read More

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November 2018

Predictors of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci co-colonization among nursing facility patients.

Am J Infect Control 2018 Nov 27. Epub 2018 Nov 27.

Department of Internal Medicine, Division of Geriatric and Palliative Medicine, University of Michigan Medical School, Ann Arbor, MI; Geriatrics Research Education and Clinical Center, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI.

Background: The emergence of vancomycin-resistant Staphylococcus aureus (VRSA) poses significant challenges for antibiotic therapy. We characterized the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) co-colonization that may facilitate resistance transfer and vancomycin-resistant S aureus emergence among nursing facility patients.

Methods: We cultured newly admitted patient hands, nares, oropharynx, groin, and perianal region plus wounds and device insertion sites, if applicable, upon enrollment at day 14, day 30, and monthly follow-up up to 6 months. Read More

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November 2018
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Novel antibacterial modalities against methicillin resistant Staphylococcus aureus derived from plants.

Crit Rev Food Sci Nutr 2018 Dec 3:1-9. Epub 2018 Dec 3.

a Department of Food Science and Nutrition, National Engineering Laboratory of Intelligent Food Technology and Equipment , Zhejiang University , Hangzhou , Zhejiang , China.

Methicillin-resistant Staphylococcus aureus (MRSA) is a notorious bacterial pathogen that induces high mortality and morbidity. Due to the emergence of multiple resistance, antibiotic treatments are rapidly becoming ineffective for the related infections. Natural products, especially those derived from plants, have been proven to be effective agents with unique antibacterial properties through different mechanisms. Read More

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December 2018

Vancomycin-induced severe thrombocytopenia in a young infant.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):873-875

Department of Pharmacy, Xiamen Maternity and Child Care Hospital, Xiamen, Fujian, China.

Vancomycin is a first-line drug for treating methicillin-resistant Staphylococcus aureus. Thrombocytopenia is a rare adverse reaction to vancomycin treatment, and there are no reports of vancomycin-induced thrombocytopenia (VIT) in infants. We describe the case of a 3-month-old girl who was diagnosed with purulent meningitis. Read More

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April 2018
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Etiology of Childhood Otorrhea in Luanda, Angola, and a Review of Otitis Media in African Children.

Pediatr Infect Dis J 2018 Dec 3. Epub 2018 Dec 3.

Children's Hospital, Helsinki University Hospital, Helsinki, Finland and University of Helsinki, Helsinki, Finland.

Background: In resource-poor settings, otorrhea causes a significant burden of disease in children. Etiologic studies and structured data on otorrhea and chronic otitis media among African children remain scarce.

Methods: Here, we reviewed 678 bacteriologically analyzed otorrhea samples from Luanda Children's Hospital from children ≤15 years of age between 2008 and 2015. Read More

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December 2018
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