8,275 results match your criteria MCN - The American Journal of Maternal/Child Nursing [Journal]


Sympathomimetics regulate neuromuscular junction transmission through TRPV1, P/Q- and N-type Ca channels.

Mol Cell Neurosci 2019 Feb 11. Epub 2019 Feb 11.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America; Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, NC, United States of America. Electronic address:

Increasing evidence indicates that, first, the sympathetic nervous system interacts extensively with both vasculature and skeletal muscle fibers near neuromuscular junctions (NMJs) and, second, its neurotransmitter, noradrenaline, influences myofiber molecular composition and function and motor innervation. Since sympathomimetic agents have been reported to improve NMJ transmission, we examined whether two in clinical use, salbutamol and clenbuterol, affect the motor axon terminal via extracellular Ca and molecular targets, such as TRPV1 and P/Q- and N-type voltage-activated Ca channels. Electrophysiological recordings in ex-vivo preparations of peroneal nerves and lumbricalis muscles from young adult mice focused on spontaneous miniature end-plate potentials and singly and repetitively evoked end-plate potentials. Read More

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http://dx.doi.org/10.1016/j.mcn.2019.01.007DOI Listing
February 2019

CPEB1 is overexpressed in neurons derived from Down syndrome IPSCs and in the hippocampus of the mouse model Ts1Cje.

Mol Cell Neurosci 2019 Feb 11. Epub 2019 Feb 11.

Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, Sevilla, Spain; Instituto de Biomedicina de Sevilla, IBIS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain. Electronic address:

Trisomy 21, also known as Down syndrome (DS), is the most frequent genetic cause of intellectual impairment. In mouse models of DS, deficits in hippocampal synaptic plasticity have been observed, in conjunction with alterations to local dendritic translation that are likely to influence plasticity, learning and memory. Here we show that expression of a local translational regulator, the Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1), is enhanced in hippocampal neurons from the Ts1Cje DS mouse model. Read More

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http://dx.doi.org/10.1016/j.mcn.2019.02.002DOI Listing
February 2019

APP depletion alters selective pre- and post-synaptic proteins.

Mol Cell Neurosci 2019 Feb 11. Epub 2019 Feb 11.

Experimental Dementia Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden; Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, USA. Electronic address:

The normal role of Alzheimer's disease (AD)-linked amyloid precursor protein (APP) in the brain remains incompletely understood. Previous studies have reported that lack of APP has detrimental effects on spines and electrophysiological parameters. APP has been described to be important in synaptic pruning during development. Read More

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http://dx.doi.org/10.1016/j.mcn.2019.02.003DOI Listing
February 2019

First Report of a Puccinia graminis f. sp. tritici Race Virulent to the Sr24 and Sr31 Wheat Stem Rust Resistance Genes in South Africa.

Plant Dis 2010 Jun;94(6):784

ARC-Small Grain Institute, Private Bag X29, Bethlehem 9700, South Africa.

Isolates of Puccinia graminis f. sp. tritici belonging to the Ug99 race group are virulent to a broad spectrum of resistance genes, rendering most of the world's wheat germplasm susceptible to stem rust (3). Read More

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http://dx.doi.org/10.1094/PDIS-94-6-0784CDOI Listing

Interleukin-16 inhibits sodium channel function and GluA1 phosphorylation via CD4- and CD9-independent mechanisms to reduce hippocampal neuronal excitability and synaptic activity.

Mol Cell Neurosci 2019 Feb 6. Epub 2019 Feb 6.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. Electronic address:

Interleukin 16 (IL-16) is a cytokine that is primarily associated with CD4 T cell function, but also exists as a multi-domain PDZ protein expressed within cerebellar and hippocampal neurons. We have previously shown that lymphocyte-derived IL-16 is neuroprotective against excitotoxicity, but evidence of how it affects neuronal function is limited. Here, we have investigated whether IL-16 modulates neuronal excitability and synaptic activity in mouse primary hippocampal cultures. Read More

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http://dx.doi.org/10.1016/j.mcn.2019.01.002DOI Listing
February 2019

Genotoxic and mutagenic assessment of spinosad using bioassays with Tradescantia pallida and Drosophila melanogaster.

Chemosphere 2019 Jan 31;222:503-510. Epub 2019 Jan 31.

Institute of Biotechnology, Federal University of Uberlândia, Campus Umuarama, 38900-402, Uberlândia, Minas Gerais, Brazil.

Spinosad (SPN) is a naturally-occurring insecticide obtained from the fermentation process of the actinomycete Saccharopolyspora spinosa. Owing to the larvicidal action, the compound has been used in the control of Aedes aegypti. As a new insecticide commercially available in the market, few data are reported on genotoxic effects in non-target organisms. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.182DOI Listing
January 2019

[A Case of Resection of a Mucinous Cystic Neoplasm of the Liver].

Gan To Kagaku Ryoho 2018 Dec;45(13):2303-2305

Dept. of Surgery, Toyonaka Municipal Hospital.

A 55 -year-old woman presented at our hospital in 2017. In 2014, a large cyst had been detected in her liver by ultrasonography, and she was followed up at a clinic. Abdominal computed tomography(CT)revealed a large multilocular cystic tumor measuring 12 cm in diameter in the left lobe of the liver. Read More

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December 2018

Proinflammatory Pathways in the Pathogenesis of Asthma.

Clin Chest Med 2019 Mar;40(1):29-50

Department of Pathobiology, Respiratory Institute, Cleveland Clinic Lerner College of Medicine, CWRU, 9500 Euclid Avenue, NB2-85, Cleveland, OH 44195, USA.

There are multiple proinflammatory pathways in the pathogenesis of asthma. These include both innate and adaptive inflammation, in addition to inflammatory and physiologic responses mediated by eicosanoids. An important component of the innate allergic immune response is ILC2 activated by interleukin (IL)-33, thymic stromal lymphopoietin, and IL-25 to produce IL-5 and IL-13. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02725231183012
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http://dx.doi.org/10.1016/j.ccm.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364573PMC
March 2019
2 Reads

Naturally-Derived Biphasic Calcium Phosphates through Increased Phosphorus-Based Reagent Amounts for Biomedical Applications.

Materials (Basel) 2019 Jan 25;12(3). Epub 2019 Jan 25.

Department of Metallic Materials Science, Physical Metallurgy, University Politehnica of Bucharest, 313 Splaiul Independentei, J Building, District 6, 060042 Bucharest, Romania.

Calcium carbonate from marble and seashells is an eco-friendly, sustainable, and largely available bioresource for producing natural bone-like calcium phosphates (CaPs). Based on three main objectives, this research targeted the: (i) adaptation of an indirect synthesis route by modulating the amount of phosphorus used in the chemical reaction, (ii) comprehensive structural, morphological, and surface characterization, and (iii) biocompatibility assessment of the synthesized powdered samples. The morphological characterization was performed on digitally processed scanning electron microscopy (SEM) images. Read More

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http://dx.doi.org/10.3390/ma12030381DOI Listing
January 2019

Association between Lactation and Postpartum Blood Pressure in Women with Preeclampsia.

MCN Am J Matern Child Nurs 2019 Jan 24. Epub 2019 Jan 24.

Adriane Burgess is an Assistant Professor of Nursing at Towson University and Clinical Research Specialist for the Women and Children Service Line, WellSpan Health, York, PA. The author can be reached via email at Wendy McDowell is a Perinatal Case Manager and lactation consultant at York Hospital, York, PA. Stacie Ebersold is a Family Health Nurse Practitioner student at Millersville University, Millersville, PA.

Purpose: Preeclampsia affects 3% to 8% of all pregnancies. There are two distinct subtypes; early- (<34 weeks) and late-onset (≥34 weeks). Each subtype is associated with increased risk of cardiovascular disease. Read More

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http://dx.doi.org/10.1097/NMC.0000000000000502DOI Listing
January 2019
3 Reads

Women's Experiences of Breastfeeding-Related Pain.

MCN Am J Matern Child Nurs 2019 Jan 24. Epub 2019 Jan 24.

Kimberley T. Jackson is an Assistant Professor, Arthur Labatt Family School of Nursing, Western University, Ontario, Canada. The author can be reached via e-mail at Tara Mantler is an Assistant Professor, School of Health Studies, Western University, Ontario, Canada. Sheila O'Keefe-McCarthy is an Assistant Professor, Department of Nursing, Brock University, Ontario, Canada.

Purpose: Breastfeeding-related pain is commonly experienced early in the postpartum period and is an important contributor to breastfeeding cessation, yet little is known about what this pain means to women and how it is experienced. The purpose of this study was to gain a better understanding of the phenomenon of breastfeeding-related pain, how women experience this pain, and the meaning it holds for them.

Study Design And Methods: Interpretive descriptive methods and inductive content analysis were used. Read More

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http://dx.doi.org/10.1097/NMC.0000000000000508DOI Listing
January 2019
2 Reads

Stem cells in animal models of Huntington disease: A systematic review.

Mol Cell Neurosci 2019 Jan 24;95:43-50. Epub 2019 Jan 24.

Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder encoding a mutant form of the huntingtin protein (HTT). HD is pathologically characterized by loss of neurons in the striatum and cortex, which leads to progressive motor dysfunction, cognitive decline and behavioral symptoms. Stem cell-based therapy has emerged as a feasible therapeutic approach for the treatment of neurodegenerative diseases and may be effective in alleviating and/or halting the pathophysiological mechanisms underlying HD. Read More

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http://dx.doi.org/10.1016/j.mcn.2019.01.006DOI Listing
January 2019
1 Read

Multifunctional nanoplatform for photoacoustic imaging-guided combined therapy enhanced by CO induced ferroptosis.

Biomaterials 2019 Mar 18;197:268-283. Epub 2019 Jan 18.

State Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, China. Electronic address:

A multifunctional CO/thermo/chemotherapy nanoplatform is here reported, which is composed of mesoporous carbon nanoparticles (MCN) as near infrared (NIR)-responsive drug carrier, doxorubicin (DOX) as chemotherapeutic drug and triiron dodecacarbonyl (FeCO) as thermosensitive CO prodrug. The nanoplatform could absorb near-infrared (NIR) light and convert it into ample heat to trigger CO release and could also release DOX in the acidic tumor microenvironment. More importantly, the generated CO molecules successfully increase cancer cell sensitivity to chemotherapeutics by the ferroptosis pathway. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.026DOI Listing
March 2019
2 Reads

Norepinephrine control of ventromedial hypothalamic nucleus glucoregulatory neurotransmitter expression in the female rat: Role of monocarboxylate transporter function.

Mol Cell Neurosci 2019 Jan 17. Epub 2019 Jan 17.

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, United States of America. Electronic address:

The ventromedial hypothalamic nucleus (VMN) is a critical component of the neural circuitry that regulates glucostasis. Astrocyte glycogen is a vital reserve of glucose and its oxidizable metabolite L-lactate. In hypoglycemic female rats, estradiol-dependent augmentation of VMN glycogen phosphorylase (GP) protein requires hindbrain catecholamine input. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10447431183030
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http://dx.doi.org/10.1016/j.mcn.2019.01.004DOI Listing
January 2019
2 Reads

Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury.

Crit Care 2019 Jan 18;23(1):18. Epub 2019 Jan 18.

Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, T1218 MCN, 1161 21st, Avenue S, Nashville, TN, 37232, USA.

Background: Vascular endothelial cadherin (VE-cadherin) is a membrane protein that is the major component of adherens junctions between endothelial cells. It is crucial for regulating vascular integrity, endothelial permeability, and angiogenesis. During inflammatory processes, VE-cadherin is shed into circulation (sVE-cadherin). Read More

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https://ccforum.biomedcentral.com/articles/10.1186/s13054-01
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http://dx.doi.org/10.1186/s13054-019-2315-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339439PMC
January 2019
5 Reads

Acute Flaccid Myelitis: A Rare but Devastating Illness.

Authors:
Judy A Beal

MCN Am J Matern Child Nurs 2019 Jan 11. Epub 2019 Jan 11.

Judy A. Beal is a Professor and Dean, College of Natural, Behavioral, and Health Sciences, Simmons University, Boston, MA. Dr. Beal can be reached via e-mail at

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http://dx.doi.org/10.1097/NMC.0000000000000515DOI Listing
January 2019
3 Reads

Birth Tourism among Chinese Women.

MCN Am J Matern Child Nurs 2019 Jan 11. Epub 2019 Jan 11.

Juanita Jaramillo is an Assistant Professor and Assistant Director, Ventura College School of Nursing, Ventura, CA. Deepika Goyal is a Professor, The Valley Foundation School of Nursing, San José State University, San Jose, CA. The author can be reached via email at Carmen Lung is a certified nurse midwife at Kaiser Permanente, Baldwin Park, CA.

Purpose: To explore the reasons why some Chinese women travel to the United States on a tourist visa specifically to give birth, also known as birth tourism.

Study Design: Qualitative, exploratory design.

Methods: Using convenience and snowball sampling, Chinese women were recruited from the waiting rooms of obstetricians known to care for birth tourists. Read More

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http://dx.doi.org/10.1097/NMC.0000000000000500DOI Listing
January 2019
6 Reads

A Customizable Protocol for String Assembly gRNA Cloning (STAgR).

J Vis Exp 2018 Dec 26(142). Epub 2018 Dec 26.

MCN Junior Research Group, Munich Center for Neurosciences, Ludwig Maximilian Universitat, BioMedical Center; Institute of Stem Cell Research, Helmholtz Zentrum, German Research Center for Environmental Health;

The bacterial CRISPR/Cas9 system has substantially increased methodological options for life scientists. Due to its utilization, genetic and genomic engineering became applicable to a large range of systems. Moreover, many transcriptional and epigenomic engineering approaches are now generally feasible for the first time. Read More

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https://www.jove.com/video/58556/a-customizable-protocol-for
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http://dx.doi.org/10.3791/58556DOI Listing
December 2018
5 Reads

Correction to: Health care providers' support of patients' autonomy, phosphate medication adherence, race and gender in end-stage renal disease.

J Behav Med 2019 Jan 8. Epub 2019 Jan 8.

Division of Nephrology and Hypertension, Vanderbilt University Medical Center, 1161 21st Avenue MCN S-3223, Nashville, TN, 37232, USA.

In the original publication of the article, the majority of changes stem from misclassification of "medium adherence" when using the Morisky Medication Adherence Scale (MMAS-8) and not using the correct scoring algorithm for one of the responses when calculating MMAS-8 total scores. Read More

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http://dx.doi.org/10.1007/s10865-018-9992-xDOI Listing
January 2019
6 Reads

Glucose-Regulated TET2 Activity Links Cancer to Diabetes.

Trends Cancer 2019 Jan 7;5(1):5-7. Epub 2018 Nov 7.

MCN Junior Research Group, Munich Center for Neurosciences, Ludwig-Maximilian-Universität, Biomedical Center, Grosshaderner Strasse 9, Planegg-Martinsried 82152, Germany; Epigenetic Engineering, Institute of Stem Cell Research, Helmholtz Zentrum, German Research Center for Environmental Health, Neuherberg D-85764, Germany. Electronic address:

Diabetes has long been associated with an increased risk of cancer. While many molecular connections likely exist between the diseases, a recent publication discovered a clear molecular link, demonstrating that a glucose-dependent destabilisation of the DNA demethylase TET2 can promote malignant transformation via an AMPK-dependent phosphoswitch. Read More

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http://dx.doi.org/10.1016/j.trecan.2018.10.008DOI Listing
January 2019

siRNA-mediated knockdown of B3GALT4 decreases GM1 ganglioside expression and enhances vulnerability for neurodegeneration.

Mol Cell Neurosci 2019 Jan 3;95:25-30. Epub 2019 Jan 3.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States of America. Electronic address:

Reduced levels of brain gangliosides GD1a, GD1b, GT1b and to a lesser extent GM1 have been found in substantia nigra (SN) from Parkinson's disease (PD) patients, along with decreased gene expression for key enzymes (B3Galt4, St3gal2) involved in synthesis of these gangliosides. Based on these observations, the present study examined the extent to which decreased expression of B3GALT4 mRNA and resulting decreased levels of GM1 ganglioside in dopaminergic cells may increase the vulnerability of these cells to degeneration in response to a neurotoxicant exposure that under normal circumstances would not result in neurodegeneration. Differentiated SK-N-SH cells were treated with B3GALT4 siRNA to significantly reduce B3GALT4 mRNA expression and decrease GM1 levels. Read More

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http://dx.doi.org/10.1016/j.mcn.2019.01.001DOI Listing
January 2019

Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice.

Mol Cell Neurosci 2019 Jan 2;95:31-42. Epub 2019 Jan 2.

Department of Psychiatry, Kawasaki Medical School, Kurashiki 701-0192, Japan. Electronic address:

Aging is associated with decline in cognitive function, but the underlying mechanisms have not been elucidated. Normal activity of pyramidal cells and parvalbumin-expressing interneurons (PV neurons) is essential for cognitive function. PV neurons participate in the regulation of pyramidal-cell firing. Read More

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http://dx.doi.org/10.1016/j.mcn.2018.12.008DOI Listing
January 2019

Ouabain activates transcription factor EB and exerts neuroprotection in models of Alzheimer's disease.

Mol Cell Neurosci 2018 Dec 28;95:13-24. Epub 2018 Dec 28.

Department of Brain Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Bio-Medical Institute of Technology (BMIT), University of Ulsan College of Medicine, Seoul, Republic of Korea; Institute for Innovation in Neurodegenerative Diseases, ADEL, Inc., Seoul, Republic of Korea. Electronic address:

The number of neurofibrillary tangles containing abnormal hyperphosphorylated tau protein correlates with the degree of dementia in Alzheimer's disease (AD). In addition, autophagosome accumulation and disturbance of autophagy, the process by which toxic aggregate proteins are degraded in the cytosol, are also found in AD models. These indicate that regulation of the autophagy-lysosome system may be a potential therapeutic target for AD. Read More

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http://dx.doi.org/10.1016/j.mcn.2018.12.007DOI Listing
December 2018

The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis.

Cell Rep 2018 Dec;25(12):3241-3251.e5

Institute of Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg, Germany; Department for Cell Biology and Anatomy, Biomedical Center of LMU, 82152 Planegg, Munich, Germany. Electronic address:

Zebrafish have a high capacity to replace lost neurons after brain injury. New neurons involved in repair are generated by a specific set of glial cells, known as ependymoglial cells. We analyze changes in the transcriptome of ependymoglial cells and their progeny after injury to infer the molecular pathways governing restorative neurogenesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183181
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http://dx.doi.org/10.1016/j.celrep.2018.11.055DOI Listing
December 2018
3 Reads

Impairment of chaperone-mediated autophagy affects neuronal homeostasis through altered expression of DJ-1 and CRMP-2 proteins.

Mol Cell Neurosci 2018 Dec 15;95:1-12. Epub 2018 Dec 15.

Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece; Second Department of Neurology, National and Kapodistrian University of Athens Medical School, Athens, Greece. Electronic address:

Chaperone-mediated autophagy (CMA) is a substrate-specific mode of lysosomal proteolysis, with multiple lines of evidence connecting its dysfunction to both ageing and disease. We have recently shown that CMA impairment through knock-down of the lysosomal receptor LAMP2A is detrimental to neuronal viability in vivo; however, it is not clear which subset of proteins regulated by the CMA pathway mediate such changes. In this study, we have manipulated CMA function through alterations of LAMP2A abundance in primary rat cortical neurons, to identify potential changes to the neuronal proteome occurring prior to neurotoxic effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10447431183018
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http://dx.doi.org/10.1016/j.mcn.2018.12.006DOI Listing
December 2018
4 Reads

Cerebrospinal fluid biomarker for Parkinson's disease: An overview.

Mol Cell Neurosci 2018 Dec 10. Epub 2018 Dec 10.

University Medical Center, Department of Neurology, Robert-Koch Strasse 40, 37075 Goettingen, Germany.

In Parkinson's disease (PD), there is a wide field of recent and ongoing search for useful biomarkers for early and differential diagnosis, disease monitoring or subtype characterization. Up to now, no biofluid biomarker has entered the daily clinical routine. Cerebrospinal fluid (CSF) is often used as a source for biomarker development in different neurological disorders because it reflects changes in central-nervous system homeostasis. Read More

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http://dx.doi.org/10.1016/j.mcn.2018.12.005DOI Listing
December 2018
1 Read

Voltammetric immunoassay of human IgG based on the release of cadmium(II) from CdS nanocrystals deposited on mesoporous silica nanospheres.

Mikrochim Acta 2018 12 12;186(1):15. Epub 2018 Dec 12.

Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, Department of Chemistry, Hubei Normal University, Huangshi, 435002, People's Republic of China.

The authors describe a nanocomposite that was obtained by in-situ deposition of CdS nanocrystals on mesoporous silica nanospheres (MSNs), and its use in an electrochemical immunoassay of human immunoglobulin G (HIgG). The MCN/CdS nanocomposite was covalently modified with the antibodies against HIgG and then employed in a voltammetric immunoassay at antibody-functionalized magnetic beads. Through sandwich immunoreaction, the MCN/CdS nanoprobes are quantitatively captured onto the magnetic beads where numerous Cd(II) ions are released in an acidic solution. Read More

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http://link.springer.com/10.1007/s00604-018-3142-6
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http://dx.doi.org/10.1007/s00604-018-3142-6DOI Listing
December 2018
8 Reads

Treatment of multiple myeloma with renal involvement: the nephrologist's view.

Clin Kidney J 2018 Dec 1;11(6):777-785. Epub 2018 Aug 1.

Nephrology Department, Hospital Universitari de Bellvitge, Idibell, Barcelona, Spain.

Renal injury is a common complication in multiple myeloma (MM). In fact, as many as 10% of patients with MM develop dialysis-dependent acute kidney injury related to increased free light chain (FLC) production by a plasma cell clone. Myeloma cast nephropathy (MCN) is the most prevalent pathologic diagnosis associated with renal injury, followed by light chain deposition disease and light chain amyloidosis. Read More

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http://dx.doi.org/10.1093/ckj/sfy065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275441PMC
December 2018
1 Read

Building a Hepatitis C Clinical Program: Strategies to Optimize Outcomes.

Curr Treat Options Infect Dis 2018 18;10(4):431-446. Epub 2018 Oct 18.

2Division of Infectious Diseases, Vanderbilt University Medical Center, A2200 MCN, 1161 21st Avenue, Nashville, TN 37232-2605 USA.

Purpose Of Review: An increasing number of specialists and non-specialists are developing clinical programs to treat and cure hepatitis C virus (HCV). The goal of this paper is to evaluate and describe optimal strategies to improve outcomes related to HCV care delivery.

Recent Findings: Screening and diagnosis of HCV should be guided by established recommendations. Read More

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http://dx.doi.org/10.1007/s40506-018-0177-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244618PMC
October 2018

Fluid and PET biomarkers for amyloid pathology in Alzheimer's disease.

Mol Cell Neurosci 2018 Dec 8. Epub 2018 Dec 8.

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, University College, London, United Kingdom of Great Britain and Northern Ireland; Department of Molecular Neuroscience, UCL Institute of Neurology, United Kingdom of Great Britain and Northern Ireland; UK Dementia Research Institute at UCL, United Kingdom of Great Britain and Northern Ireland.

Alzheimer's disease (AD) is characterized by amyloid plaques and tau pathology (neurofibrillary tangles and neuropil threads). Amyloid plaques are primarily composed of aggregated and oligomeric β-amyloid (Aβ) peptides ending at position 42 (Aβ42). The development of fluid and PET biomarkers for Alzheimer's disease (AD), has allowed for detection of Aβ pathology in vivo and marks a major advancement in understanding the role of Aβ in Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1016/j.mcn.2018.12.004DOI Listing
December 2018
10 Reads

Support for Young Black Urban Women After Perinatal Loss.

Authors:

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1):E1-E2

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http://dx.doi.org/10.1097/NMC.0000000000000511DOI Listing
December 2018

The Tragedy of Trafficking of Women and Children.

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1):55

Lynn Clark Callister is a Professor Emerita, College of Nursing, Brigham Young University, Provo, UT, and an Editorial Board Member of MCN. Dr. Callister can be reached via e-mail at

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http://dx.doi.org/10.1097/NMC.0000000000000491DOI Listing
December 2018

Pregnancy After Bariatric Surgery: Nutritional Concerns.

Authors:
Denise Snow

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1):54

Denise Snow is a clinical associate professor in the School of Nursing at the State University of New York at Stonybrook, Stonybrook, NY, and a healthcare law attorney in private practice. Dr. Snow can be reached via e-mail at

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http://dx.doi.org/10.1097/NMC.0000000000000497DOI Listing
December 2018

Toxic Stress in Children.

Authors:
Judy A Beal

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1):53

Judy A. Beal is Professor and Dean, School of Nursing and Health Sciences, Simmons University, Boston, MA. Dr. Beal can be reached via e-mail at

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http://dx.doi.org/10.1097/NMC.0000000000000487DOI Listing
December 2018

Intrapartum Management of Women With Human Immunodeficiency Virus Infection.

Authors:
Kirsten Wisner

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1):52

Kirsten Wisner is the Magnet Program Director at Salinas Valley Memorial Healthcare System. Ms. Wisner can be reached via e-mail at

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http://dx.doi.org/10.1097/NMC.0000000000000492DOI Listing
December 2018
2 Reads

Nurses' Perspective on Caring for Women Experiencing Perinatal Loss.

Authors:
Patricia Willis

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1):46-51

Patricia Willis is an Assistant Professor, Massasoit Community College, Brockton, MA. The author can be reached via e-mail at

Purpose: The purpose of this study was to describe the experience of caring for women with a perinatal loss from the perspective of the nurse and to determine the extent to which the response to perinatal loss reflects a process.

Study Design And Methods: A purposive study was conducted with nine labor and birth nurses with experience in caring for women with a perinatal loss. The nurses were from two acute care hospitals within one healthcare system in Southeastern Massachusetts. Read More

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http://dx.doi.org/10.1097/NMC.0000000000000490DOI Listing
December 2018

Attitudes of Physicians, Midwives, and Nurses About Doulas: A Scoping Review.

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1):33-39

Laura Lucas is an Assistant Professor, Johns Hopkins University School of Nursing, Baltimore, MD. The author can be reached via e-mail at Erin Wright is an Assistant Professor, Johns Hopkins University School of Nursing, Baltimore, MD.

Introduction: Evidence supports numerous positive clinical benefits of doula care. There are varying attitudes among physicians, midwives, and nurses toward support of doulas in a collaborative approach with women in labor. Tension and conflict with use of doulas may occur in some intrapartum settings in the United States. Read More

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http://dx.doi.org/10.1097/NMC.0000000000000488DOI Listing
December 2018
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Application of Caring Theory to Nursing Care of Women Experiencing Stillbirth.

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1):27-32

Natasha Nurse-Clarke is a Lecturer, Department of Nursing, Herbert H. Lehman College, City University of New York, Bronx, NY. The author can be reached via e-mail at Barbara DiCicco-Bloom is an Associate Professor, Department of Nursing, College of Staten Island, City University of New York, New York, NY. Rana Limbo is Director Emeritus, Resolve Through Sharing, Gundersen Medical Foundation, La Crosse, WI.

Purpose: The purpose of this study was to determine the extent to which labor and delivery nurses used the tenets of Swanson's middle-range theory to care for women whose babies were stillborn.

Study Design And Methods: A secondary analysis of qualitative in-depth interview data from 20 labor and delivery nurses obtained during a recent grounded theory study was conducted using the directed content analysis method. The five caring processes as described in Swanson's theory were used as a priori codes to conduct the analysis. Read More

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http://dx.doi.org/10.1097/NMC.0000000000000494DOI Listing
December 2018

Using Theory to Inform and Guide Perinatal Bereavement Care.

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1):20-26

Marianne H. Hutti is a Professor, University of Louisville, School of Nursing, Louisville, KY. The author can be reached via e-mail at Rana Limbo is Director Emeritus, Resolve Through Sharing, Gundersen Medical Foundation.

Providing nursing care to perinatally bereaved women and their families is difficult, emotionally demanding, and complicated. Here we demonstrate how, through understanding the theoretical underpinnings of Guided Participation and perinatal grief intensity, nurses can significantly expand their competence and confidence in their ability to provide highly individualized, supportive, relationship-based perinatal bereavement care. The way that parents respond to a perinatal loss may range from little response to highly intense, long-lasting grief. Read More

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http://dx.doi.org/10.1097/NMC.0000000000000495DOI Listing
December 2018

Perinatal Bereavement Care.

Authors:
Marianne H Hutti

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1)

Rana Limbo is Director Emeritus, Resolve Through Sharing, Gundersen Medical Foundation, LaCrosse, WI. Dr. Limbo can be reached via e-mail at Marianne H. Hutti is a Professor, University of Louisville, School of Nursing, Louisville, KY.

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http://dx.doi.org/10.1097/NMC.0000000000000496DOI Listing
December 2018

Biomarkers for tau pathology.

Mol Cell Neurosci 2018 Dec 7. Epub 2018 Dec 7.

Helen Wills Neuroscience Institute, University of California, Berkeley, USA; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

The aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-associated tau protein characterizes 80% of all dementia disorders, the most common neurodegenerative disorders. These so-called tauopathies are hitherto not curable and their diagnosis, especially at early disease stages, has traditionally proven difficult. A keystone in the diagnosis of tauopathies was the development of methods to assess levels of tau protein in vivo in cerebrospinal fluid, which has significantly improved our knowledge about these conditions. Read More

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http://dx.doi.org/10.1016/j.mcn.2018.12.001DOI Listing
December 2018
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Melanocortin 4 receptor activation protects striatal neurons and glial cells from 3-nitropropionic acid toxicity.

Mol Cell Neurosci 2019 Jan 4;94:41-51. Epub 2018 Dec 4.

Instituto de Investigaciones Biomédicas (INBIOMED) UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. Electronic address:

α-Melanocyte stimulating hormone (α-MSH) is a melanocortin which exerts potent anti-inflammatory and anti-apoptotic effects. Melanocortin 4 receptors (MC4R) are abundantly expressed in the brain and we previously demonstrated that [Nle(4), D-Phe(7)]melanocyte-stimulating hormone (NDP-MSH), an α-MSH analogue, increased expression of brain derived-neurotrophic factor (BDNF), and peroxisome proliferator-activated receptor-γ (PPAR-γ). We hypothesized that melanocortins could affect striatal cell survival through BDNF and PPAR-γ. Read More

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http://dx.doi.org/10.1016/j.mcn.2018.12.002DOI Listing
January 2019

Review: Fluid biomarkers in the human prion diseases.

Mol Cell Neurosci 2018 Dec 4. Epub 2018 Dec 4.

MRC Prion Unit at University College London (UCL), UCL Institute of Prion Diseases, UCL, London W1W 7FF, United Kingdom of Great Britain and Northern Ireland. Electronic address:

The human prion diseases are a diverse set of often rapidly progressive neurodegenerative conditions associated with abnormal forms of the prion protein. We review work to establish diagnostic biomarkers and assays that might fill other important roles, particularly those that could assist the planning and interpretation of clinical trials. The field now benefits from highly sensitive and specific diagnostic biomarkers using cerebrospinal fluid: detecting by-products of rapid neurodegeneration or specific functional properties of abnormal prion protein, with the second generation real time quaking induced conversion (RT-QuIC) assay being particularly promising. Read More

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http://dx.doi.org/10.1016/j.mcn.2018.12.003DOI Listing
December 2018

Evaluating Response Time in Zanzibar's Malaria Elimination Case-Based Surveillance-Response System.

Am J Trop Med Hyg 2019 Feb;100(2):256-263

RTI International, Dar es Salaam, Tanzania.

As countries transition toward malaria elimination, malaria programs rely on surveillance-response systems, which are often supported by web- and mobile phone-based reporting tools. Such surveillance-response systems are interventions for elimination, making it important to determine if they are operating optimally. A metric to measure this by is timeliness. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367619PMC
February 2019

Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture.

Tissue Eng Part A 2018 Nov 28. Epub 2018 Nov 28.

Vanderbilt University Medical Center, 12328, Medicine , 1161 21st Avenue South , S3223 MCN , Nashville, Tennessee, United States , 37232-2102 ;

End-stage renal disease afflicts nearly 750,000 Americans and claims over 100,000 lives annually in the United States. Kidney transplantation is associated with longest survival and least cost but is limited by scarcity of donor organs. Most patients are treated with hemodialysis. Read More

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http://dx.doi.org/10.1089/ten.TEA.2018.0182DOI Listing
November 2018
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Consumer health-related needs of pregnant women and their caregivers.

JAMIA Open 2018 Jul 18;1(1):57-66. Epub 2018 Jun 18.

Department of Surgery, Vanderbilt University Medical Center, 1161 21st Ave S, CCC-4312 MCN, Nashville, Tennessee 37232-2730, USA.

Objectives: To build effective applications, technology designers must understand consumer health needs. Pregnancy is a common health condition, and expectant families have unanswered questions. This study examined consumer health-related needs in pregnant women and caregivers and determined the types of needs that were not met. Read More

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https://academic.oup.com/jamiaopen/article/1/1/57/5039935
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http://dx.doi.org/10.1093/jamiaopen/ooy018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241505PMC
July 2018
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Pancreatic Cysts: Sinister Findings or Incidentalomas?

Med Clin North Am 2019 Jan;103(1):163-172

Medicine, Multidisciplinary Pancreatic Cyst Clinic, The Johns Hopkins Medical Institutions, 1800 Orleans Street, Room 7125J, Baltimore, MD 21231, USA; Surgery, Multidisciplinary Pancreatic Cyst Clinic, The Johns Hopkins Medical Institutions, 1800 Orleans Street, Room 7125J, Baltimore, MD 21231, USA; Oncology, Multidisciplinary Pancreatic Cyst Clinic, The Johns Hopkins Medical Institutions, 1800 Orleans Street, Room 7125J, Baltimore, MD 21231, USA; Radiology, Multidisciplinary Pancreatic Cyst Clinic, The Johns Hopkins Medical Institutions, 1800 Orleans Street, Room 7125J, Baltimore, MD 21231, USA. Electronic address:

Pancreatic cysts are common and are incidentally detected in up to 13.5% of individuals. Intraductal papillary mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN) are precursors to pancreatic adenocarcinoma. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.08.004DOI Listing
January 2019
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Support for Young Black Urban Women After Perinatal Loss.

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1):13-19

Kimberly H. Fenstermacher is an Associate Professor of Nursing, Chair, Department of Nursing, Messiah College, Mechanicsburg, PA. The author can be reached via e-mail at Judith E. Hupcey is a Professor of Nursing & Medicine, Associate Dean for Graduate Education & Research, College of Nursing, the Pennsylvania State University, University Park, PA.

Purpose: To describe the bereavement support needs of black urban women in late adolescence after perinatal loss.

Study Design And Methods: Eight black women aged 18 to 21 years who had experienced recent perinatal loss were interviewed in person or by telephone at three points in the 12 weeks that followed their loss to describe their perinatal bereavement experience and support needs. Data from the interviews were analyzed using constant comparative analysis. Read More

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http://Insights.ovid.com/crossref?an=00005721-900000000-9984
Publisher Site
http://dx.doi.org/10.1097/NMC.0000000000000485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289796PMC
January 2020
15 Reads

Normal Complications and Abnormal Assumptions After Perinatal Death.

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1):6-12

Joanne Cacciatore is an Associate Professor, School of Social Work, Arizona State University, Phoenix, AZ. The author can be reached via e-mail at Kara Thieleman is a Doctoral Student, School of Social Work, Arizona State University, Phoenix, AZ.

There are several ways, clinically, to approach grief after perinatal death, including from a humanistic or a medicalized perspective. The death of a baby is complicated. The loss is an embodied one that incites deep psychological wounds and can be isolating for many parents. Read More

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http://Insights.ovid.com/crossref?an=00005721-900000000-9984
Publisher Site
http://dx.doi.org/10.1097/NMC.0000000000000486DOI Listing
November 2018
10 Reads