345,452 results match your criteria Lymphoproliferative Disorders


Celiac Disease Prevalence is Increased in Primary Sjögren's Syndrome and Diffuse Systemic Sclerosis: Lessons from a Large Multi-Center Study.

J Clin Med 2019 Apr 19;8(4). Epub 2019 Apr 19.

Rheumatology Unit, Department of Medicine, University of Perugia, 06128 Perugia, Italy .

Association of celiac disease (CD) with systemic autoimmune diseases (ADs) remains controversial. Awareness of CD in these patients is important to prevent complications, including lymphoproliferative disorders. We evaluated previously diagnosed CD prevalence in systemic lupus erythematosus (SLE), primary Sjögren's syndrome (pSS) and systemic sclerosis (SSc) patients in comparison to 14,298 matched controls. Read More

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http://dx.doi.org/10.3390/jcm8040540DOI Listing

Identification of a Novel Gammaherpesvirus in Canada lynx ().

Viruses 2019 Apr 20;11(4). Epub 2019 Apr 20.

Department of Microbiology and Immunology, University of Western Ontario, 1151 Richmond St., London, ON N6A 5C1, Canada.

Gammaherpesviruses (GHVs) infect many animal species and are associated with lymphoproliferative disorders in some. Previously, we identified several novel GHVs in North American felids; however, a GHV had never been identified in Canada lynx (). We, therefore, hypothesized the existence of an unidentified GHV in lynx. Read More

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http://dx.doi.org/10.3390/v11040363DOI Listing

The high mortality of patients with common variable immunodeficiency and small bowel villous atrophy.

Scand J Gastroenterol 2019 Apr 21:1-5. Epub 2019 Apr 21.

a Coeliac Centre/First Department of Internal Medicine , Fondazione IRCCS Policlinico San Matteo University of Pavia , Pavia , Italy.

Objectives: Common variable immunodeficiency (CVID) is a primary humoral immunodeficiency characterised by reduced serum levels of immunoglobulins, recurrent infections, autoimmune phenomena and lymphoproliferative disorders. Gastrointestinal symptoms are very common in these patients and a coeliac-like villous atrophy was described in some of them. Since mortality in CVID is much higher than in the general population, our aim was to evaluate mortality rates and clinical predictors of survival in patients with both CVID and duodenal villous atrophy. Read More

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http://dx.doi.org/10.1080/00365521.2019.1568543DOI Listing

Rostrum: Itching as a systemic disease.

J Allergy Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center Miller School of Medicine University of Miami, Miami, FL. Electronic address:

Pruritus is a sensation that emanates from the skin and is transferred via peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders such as atopic eczema, skin dryness, psoriasis, and urticaria can elicit pruritus. However certain systemic diseases can cause chronic pruritus that have significant impact on patients' quality of life. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193052
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http://dx.doi.org/10.1016/j.jaci.2019.04.005DOI Listing
April 2019
2 Reads

Non-genotoxic MDM2 inhibition selectively induces pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells.

Haematologica 2019 Apr 19. Epub 2019 Apr 19.

Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK;

Chronic lymphocytic leukemia is a clinically heterogeneous haematological malignancy which is ~90% TP53 wild-type at diagnosis. As a primary repressor of p53, targeting of mouse double-minute-2 homolog (MDM2) is an attractive therapeutic approach for non-genotoxic reactivation of p53. Since discovery of the first MDM2 inhibitor, Nutlin-3a, newer potent and bioavailable compounds have been developed. Read More

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http://dx.doi.org/10.3324/haematol.2018.206631DOI Listing

Hydroa vacciniforme: a distinctive form of Epstein-Barr virus-associated T-cell lymphoproliferative disorders.

Eur J Dermatol 2019 Feb;29(1):21-28

Department of Dermatology, Kawasaki Medical School,, Department of Dermatology, Kawasaki Medical School General Medical Center, Okayama, Japan.

Hydroa vacciniforme (HV) is a cutaneous subset of Epstein-Barr virus (EBV)-associated T/NK lymphoproliferative disorders (LPDs). Our previous case series study clearly showed a clinical spectrum of EBV-associated T/NK LPDs including HV, hypersensitivity to mosquito bites (HMB), chronic active EBV infection (CAEBV), and hemophagocytic lymphohistiocytosis (HLH). Patients with HV are divided into two groups: a benign subtype designated "classic HV" (cHV) and more serious systemic HV (sHV), also called "HV-like LPD" in the 2017 World Health Organization (WHO) classification. Read More

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http://dx.doi.org/10.1684/ejd.2018.3490DOI Listing
February 2019

The impact of JAK/STAT inhibitor ruxolitinib on the genesis of lymphoproliferative diseases

Turk J Med Sci 2019 Apr 18;49(2):661-674. Epub 2019 Apr 18.

Background/aim: Ruxolitinib, a JAK/STAT signaling pathway inhibitor targeted drug, has been approved for the controlling of disease symptoms and splenomegaly in patients with myeloproliferative neoplastic diseases. Recently, it has been proposed that ruxolitinib-induced JAK/STAT pathway inhibition in myelofibrosis is associated with an elevated frequency of aggressive B-cell lymphomas. However, the biological basis and significance of this pharmacobiological adverse event is unknown. Read More

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http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=s
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http://dx.doi.org/10.3906/sag-1807-152DOI Listing
April 2019
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Tisagenlecleucel in Diffuse Large B-Cell Lymphoma. Reply.

N Engl J Med 2019 04;380(16):1586

University of Pennsylvania, Philadelphia, PA

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http://www.nejm.org/doi/10.1056/NEJMc1901464
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http://dx.doi.org/10.1056/NEJMc1901464DOI Listing
April 2019
1 Read

Tisagenlecleucel in Diffuse Large B-Cell Lymphoma.

N Engl J Med 2019 04;380(16):1585-1586

Rocket Pharmaceuticals, New York, NY

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http://www.nejm.org/doi/10.1056/NEJMc1901464
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http://dx.doi.org/10.1056/NEJMc1901464DOI Listing
April 2019
1 Read

Tisagenlecleucel in Diffuse Large B-Cell Lymphoma.

N Engl J Med 2019 04;380(16):1585

McGill University, Montreal, QC, Canada

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http://www.nejm.org/doi/10.1056/NEJMc1901464
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http://dx.doi.org/10.1056/NEJMc1901464DOI Listing
April 2019
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Clinical Aspects, Immunophenotypic Analysis and Survival Rate of Chronic Lymphocytic Leukaemia Patients in Erbil City, Iraq.

Authors:
Kawa M Hasan

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e461-e467. Epub 2019 Mar 28.

Department of Medicine, College of Medicine, Hawler Medical University, Erbil, Iraq.

Objectives: Chronic lymphocytic leukaemia (CLL) is characterised by an accumulation of clonal B cells in the blood, bone marrow and lymphatic tissue. This study aimed to evaluate the clinical and immunophenotypic characteristics and survival rate of CLL patients.

Methods: This retrospective study was conducted at the Nanakaly Hospital for Blood Diseases & Oncology in Erbil, Iraq, between January 2011 and December 2017. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443287PMC
November 2018
1 Read

Clinicopathological spectrum of renal parenchymal involvement in B-cell lymphoproliferative disorders.

Kidney Int 2019 Mar 15. Epub 2019 Mar 15.

Department of Nephrology and Renal Transplantation, Centre Hospitalier Universitaire, Université de Poitiers, Poitiers, France; CNRS UMR 7276, INSERM UMR 1262, Université de Limoges, Limoges, France; INSERM CIC 1402, Centre Hospitalier Universitaire, Poitiers, France.

The clinicopathological characteristics of kidney infiltration in B-cell lymphoproliferative disorders remain poorly described. We retrospectively studied 52 adults with biopsy-proven malignant B-cell kidney infiltration, including Waldenström's macroglobulinemia (n=21), chronic lymphocytic leukemia (n=11), diffuse large B-cell lymphoma (DLBCL) (n=8), other lymphoma (n=11), and multiple myeloma (n=1). Kidney disease varied according to the underlying lymphoproliferative disorder. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.027DOI Listing
March 2019
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Reynoutria japonica from Traditional Chinese Medicine: A source of Competitive Adenosine Deaminase Inhibitors for Anticancer.

Comb Chem High Throughput Screen 2019 Apr 14. Epub 2019 Apr 14.

Drug Evaluation and Certification Center of Gansu Food and Drug Administration, Lanzhou 730060. China.

Background: Adenosine deaminase (ADA) is an important enzyme in purine metabolism and is known as a potential therapeutic target for the treatment of lymphoproliferative disorders and cancer. Traditional Chinese Herbal Medicine (TCHM) is widely used alone or in combination with chemotherapy to treat cancer, due to its ability to deliver a broad variety of bioactive secondary metabolites as promising sources of novel organic natural agents.

Objective: In the present study, 29 varieties of medicinal plants were screened for the presence of ADA inhibitors. Read More

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http://dx.doi.org/10.2174/1386207322666190415100618DOI Listing
April 2019
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CD20-negative primary middle ear diffuse large B-cell lymphoma coexpressing MYC and BCL-2 secondary to acute lymphoblastic leukemia: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15204

Department of Hematology, The First Affiliated Hospital, Kunming Medical University, Kunming, Yunnan Province, China.

Rationale: Second diffuse large B-cell lymphoma (DLBCL) after treatment of acute lymphoblastic leukemia (ALL) is uncommon. To our knowledge, primary middle ear DLBCL which presents CD20-negative and coexpression of MYC and BCL-2 has not been reported yet.

Patient Concerns: A 20-year-old Chinese man complained fever and weakness for 2 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000015204DOI Listing
April 2019
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Diffuse large B-cell lymphoma involving peripheral nervous system with IgM antibodies against GM1 and GD1b: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15049

Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, Jilin, China.

Rationale: The occurrence of peripheral neuropathy associated with non-Hodgkin's lymphoma (NHL) is uncommon. And autoimmunity may play an important role. We report a case of the patient with NHL, has sensorimotor demyelinating polyneuropathy. Read More

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http://dx.doi.org/10.1097/MD.0000000000015049DOI Listing
April 2019
2 Reads

A case of pulmonary lymphoproliferative disorder presenting rapidly progressive respiratory failure.

Respirol Case Rep 2019 Jul 2;7(5):e00422. Epub 2019 Apr 2.

Division of Respiratory Medicine, Center for Respiratory Diseases National Hospital Organization Kyoto Medical Center Kyoto Japan.

A 72-year-old woman presented with acute onset of shortness of breath and fatigue over several days, and was found to be in acute respiratory failure. Computed tomography of the chest revealed diffuse ground-glass opacities, crazy-paving, multiple nodules, and a large mass in the right lower lobe. She was diagnosed with B-cell lymphoma and a pulmonary lymphoproliferative disorder (PLD). Read More

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http://dx.doi.org/10.1002/rcr2.422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444548PMC
July 2019
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Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management.

Front Immunol 2019 26;10:586. Epub 2019 Mar 26.

Hospital U. Vall d'Hebron, Barcelona, Spain.

Immunodeficiencies (ID), in particular primary immunodeficiencies (PID), are often associated with haematological manifestations, such as peripheral cytopenias or lymphoproliferative syndromes. Early diagnosis and management have significant prognostic implications. Secondary immunodeficiencies (SID) may also be induced by oncohaematological diseases and their treatments. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448689PMC

Primary central nervous system post-transplant lymphoproliferative disorders: the spectrum of imaging appearances and differential.

Insights Imaging 2019 Apr 11;10(1):46. Epub 2019 Apr 11.

Oncology, University of Nebraska Medical Center, 986840 Nebraska Medical Center, Omaha, NE, 68198-6840, USA.

Objective: Central nervous system post-transplant lymphoproliferative disorder (CNS-PTLD) is a rare disease that presents with non-specific signs and symptoms. The purpose of this article is to present the imaging appearances of CNS-PTLD by magnetic resonance imaging. We highlight the differential diagnostic considerations including primary central nervous system lymphoma, glioblastoma, cerebral abscess, and metastatic disease. Read More

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http://dx.doi.org/10.1186/s13244-019-0726-6DOI Listing
April 2019
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Multifocal Epstein-Barr virus-associated miliary post-transplant smooth muscle tumors.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):293-295

Department of Pathology, Cardiovascular and Thoracic Division, Seth GS Medical College, Mumbai, Maharashtra, India.

Epstein-Barr virus (EBV) promotes the development of undifferentiated carcinomas of the upper aerodigestive tract and different types of lymphomas. This ability of tumorigenesis is heightened in many immunocompromised patients who have an increased incidence of lymphoproliferative disorders. The virus also induces smooth muscle proliferation, and those occurring following transplantation are designated as EBV-associated post-transplant smooth muscle tumors. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_485_18DOI Listing
April 2019
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The Possible Role of Gut Microbiota and Microbial Translocation Profiling During Chemo-Free Treatment of Lymphoid Malignancies.

Int J Mol Sci 2019 Apr 9;20(7). Epub 2019 Apr 9.

Infectious Diseases Unit, Fondazione IRCCS "San Matteo", 27100 Pavia, Italy.

The crosstalk between gut microbiota (GM) and the immune system is intense and complex. When dysbiosis occurs, the resulting pro-inflammatory environment can lead to bacterial translocation, systemic immune activation, tissue damage, and cancerogenesis. GM composition seems to impact both the therapeutic activity and the side effects of anticancer treatment; in particular, robust evidence has shown that the GM modulates the response to immunotherapy in patients affected by metastatic melanoma. Read More

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http://dx.doi.org/10.3390/ijms20071748DOI Listing

Treatment of relapsed/refractory acute lymphoblastic leukemia.

Clin Adv Hematol Oncol 2019 Mar;17(3):166-175

University of Texas MD Anderson Cancer Center, Houston, Texas.

Patients with relapsed or refractory acute lymphoblastic leukemia (R/R ALL) have dismal outcomes, with survival of less than 6 months, and treatment options in the salvage setting have been limited to conventional cytotoxic chemotherapy with minimal activity. Advances in the development of novel targeted therapies have significantly improved outcomes in R/R ALL. Blinatumomab, inotuzumab ozogamicin, and chimeric antigen receptor (CAR) T-cell therapy constitute new treatment modalities that are challenging the historical regimens and paving a new path for treating patients with R/R ALL. Read More

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March 2019
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Autoimmune Lymphoproliferative Syndrome: An Overview.

Arch Pathol Lab Med 2019 Apr 8. Epub 2019 Apr 8.

From the Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison.

Autoimmune lymphoproliferative syndrome (ALPS) is an inherited nonmalignant lymphoproliferative disorder characterized by heterozygous mutations within the first apoptosis signal receptor (FAS) signaling pathway. Defects in FAS-mediated apoptosis cause an expansion and accumulation of autoreactive CD4 and CD8 (double-negative) T cells, leading to cytopenias, splenomegaly, lymphadenopathy, autoimmune disorders, and a greatly increased lifetime risk of lymphoma. The differential diagnosis of ALPS includes infection, other inherited immunodeficiency disorders, primary and secondary autoimmune syndromes, and lymphoma. Read More

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http://dx.doi.org/10.5858/arpa.2018-0190-RSDOI Listing
April 2019
4 Reads

Sarcoidosis.

Med Clin North Am 2019 May 21;103(3):527-534. Epub 2019 Feb 21.

Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.

Sarcoidosis is a multisystemic granulomatous disease that affects individuals worldwide. The lungs are most commonly involved but any organ can be involved. It has variable manifestations and clinical course. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.12.011DOI Listing
May 2019
2 Reads

Methotrexate-associated lymphoproliferative disorders of T-cell phenotype: clinicopathological analysis of 28 cases.

Mod Pathol 2019 Apr 5. Epub 2019 Apr 5.

Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.

Methotrexate-associated lymphoproliferative disorders are categorized as "other immunodeficiency-associated lymphoproliferative disorders in the WHO classification. Methotrexate-associated lymphoproliferative disorder is mainly a B-cell lymphoproliferative disorders or Hodgkin lymphoma type, whereas T-cell lymphoproliferative disorders are relatively rare (4-8%). Only a small number of methotrexate-associated T-cell lymphoproliferative disorders have been detailed thus far. Read More

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http://dx.doi.org/10.1038/s41379-019-0264-2DOI Listing
April 2019
2 Reads

Myelosuppression After Radiation Therapy in Patients With and Without Autologous Peripheral Blood Stem Cell Transplantation: A Retrospective Observational Study.

Anticancer Res 2019 Apr;39(4):2163-2167

Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.

Background/aim: Autologous hematopoietic stem cell transplantation (ASCT) after high-dose chemotherapy is used to treat relapsed malignant lymphomas. Radiation therapy (RT) is applied after ASCT. We compared the incidence of myelosuppression after RT with and without autologous peripheral blood stem cell transplantation (auto-PBSCT). Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13330DOI Listing
April 2019
16 Reads

Characterization of Bone Lesions in Myeloma Before and During Anticancer Therapy Using F-FDG-PET/CT and F-NaF-PET/CT.

Anticancer Res 2019 Apr;39(4):1943-1952

Department of Internal Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria.

Background: The objective of this study was to characterize tumor activity and mineralization status in newly-detected multiple myeloma (MM) bone lesions using 2-F-fluoro-2-deoxy-D-glucose (F-FDG)-PET/CT and F-sodium fluoride (F-NaF)-PET/CT before and after antitumor treatment.

Materials And Methods: In this retrospective study, seven patients with histologically-verified MM were included (four women, three men; median age=57 years, standard deviation=11.23 years). Read More

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http://dx.doi.org/10.21873/anticanres.13304DOI Listing
April 2019
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Effect of Stem Cell Transplant on Survival in Adult Patients With Acute Lymphoblastic Leukemia: NCDB Analysis.

Anticancer Res 2019 Apr;39(4):1899-1906

Department of Medicine, Section of Hematology/Oncology, Feist-Weiller Cancer Center, Louisiana State University Health Science Center, Shreveport, LA, U.S.A.

Background: A retrospective analysis was performed to investigate the survival outcomes in adult acute lymphoblastic leukemia (ALL) based on treatment received.

Materials And Methods: Data from 17,504 men and women (≥18 years of age) registered in the National Cancer Database who were diagnosed with ALL between 2004 and 2013 and had follow-up to the end of 2014, were analyzed. The primary predictor variable was treatment received, and overall survival was the outcome variable. Read More

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http://dx.doi.org/10.21873/anticanres.13298DOI Listing
April 2019
2 Reads
1.872 Impact Factor

Development of Multiple Myeloma of the IgA Type in a Patient with Cold Agglutinin Disease: Transformation or Coincidence?

Case Rep Hematol 2019 4;2019:1610632. Epub 2019 Mar 4.

Department of Research and Innovation, Haugesund Hospital, Haugesund, Norway.

Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia and a distinct, clonal bone marrow lymphoproliferative disorder, characterized in most cases by a monoclonal IgMκ serum protein. We describe a CAD patient presenting with a monoclonal immunoglobulin of the IgA class. For years, she remained asymptomatic apart from the hemolytic anemia until eventually she developed multiple myeloma (MM) of the IgA phenotype. Read More

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http://dx.doi.org/10.1155/2019/1610632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425334PMC
March 2019
1 Read

Hepatic Manifestations of Lymphoproliferative Disorders.

Clin Liver Dis 2019 May 2;23(2):293-308. Epub 2019 Mar 2.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

Hepatic abnormalities in patients with lymphoproliferative disorders are common and can occur from direct infiltration by abnormal cells, bile duct obstruction, paraneoplastic syndrome, hemophagocytic syndrome, drug-induced liver injury, opportunistic infections, and reactivation of viral hepatitis. Hepatic involvement by lymphoma is often in association with systemic disease and rarely seen as a primary hepatic lymphoma. Vanishing bile duct syndrome is a well-known complication of Hodgkin disease. Read More

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http://dx.doi.org/10.1016/j.cld.2018.12.010DOI Listing
May 2019
1 Read

Clinicopathological features of clinical methotrexate-related lymphoproliferative disorders.

Leuk Lymphoma 2019 Apr 5:1-8. Epub 2019 Apr 5.

a Department of Hematology , Saitama Medical Center, Saitama Medical University , Saitama , Japan.

Methotrexate (MTX) is one of the potent drugs for autoimmune diseases (ADs), especially for rheumatoid arthritis. Recent studies suggest that MTX should be immediately withdrawn when patients with AD develop lymphoproliferative disorder (LPD). However, biopsy cannot be performed for diagnosis because LPD regresses quickly after MTX withdrawal, thus making clinical MTX-LPD (c-MTX-LPD) challenging to diagnose. Read More

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http://dx.doi.org/10.1080/10428194.2019.1585841DOI Listing
April 2019
3 Reads

Amyloidosis secondary to intrapulmonary Castleman disease mimicking pulmonary hyalinizing granuloma-like clinical features: A rare case report.

Medicine (Baltimore) 2019 Apr;98(14):e15039

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Rationale: Amyloidosis secondary to intrapulmonary Castleman disease (CD) is a rare benign disease diagnosed by histopathology. It seems to be associated with chronic inflammation, and large amounts of IL-6 produced in the germinal center of CD may enhance the production of precursor of amyloid.

Patient Concerns: We reported a case of an 18-year-old woman presenting with dry cough and dyspnea on exertion for 6 months and detailed exams revealed multiple pulmonary nodules, positive antinuclear antibodies, hypocomplementemia, and thrombocytopenia. Read More

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http://dx.doi.org/10.1097/MD.0000000000015039DOI Listing
April 2019
2 Reads

The mechanism of formation of thin-walled cystic lung cancer.

Medicine (Baltimore) 2019 Apr;98(14):e15031

Department of Respiratory and Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University.

Thin-wall cystic lung cancer is becoming of increasing interest in the study of pulmonary medicine. Consequently, more and more different images and pathologic manifestations have been found. The purpose of this article is to find pathologic characteristics and try to explain the formation mechanism of thin-walled cystic lung cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000015031DOI Listing
April 2019
2 Reads

CT findings and clinical features of Epstein-Barr virus-associated lymphoepithelioma-like gastric carcinoma.

Medicine (Baltimore) 2019 Apr;98(14):e14839

Department of Pathology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.

Epstein-Barr virus (EBV)-associated lymphoepithelioma-like gastric carcinoma (LELGC) is a rare primary stomach tumor, which has overlapping imaging features with mass forming gastric carcinoma (GC). The aim of our study was to present the computed tomography (CT) findings and clinical features of EBV-associated LELGC to increase awareness of this entity.The CT findings and clinical features of 4 patients with pathologically documented EBV-associated LELGC were retrospectively analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000014839DOI Listing
April 2019
2 Reads

Mycosis Fungoides Associated With Lesions in the Spectrum of Primary Cutaneous CD30+ Lymphoproliferative Disorders: The Same Process or 3 Coexisting Lymphomas?

Am J Dermatopathol 2019 Mar 29. Epub 2019 Mar 29.

Departments of Dermatology.

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma, primary cutaneous CD30 lymphoproliferative disorders (pc CD30 LPD) being the second most prevalent. There is evidence that MF and pc CD30 LPD may coexist and share T-cell clonality, suggesting a common origin. These findings were supported by a T-cell receptor clonality assessment by the polymerase chain reaction coupled with capillary electrophoresis, although results produced by this method may be ambiguous. Read More

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http://Insights.ovid.com/crossref?an=00000372-900000000-9816
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http://dx.doi.org/10.1097/DAD.0000000000001423DOI Listing
March 2019
11 Reads

A Dangerous Detour.

N Engl J Med 2019 Apr;380(14):1360-1365

From the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1056/NEJMcps1803916DOI Listing
April 2019
1 Read

Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases.

Front Pediatr 2019 15;7:71. Epub 2019 Mar 15.

Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, University Hospital Tübingen, Eberhard-Karls-University, Tübingen, Germany.

EBV-associated T and NK-cell lymphoproliferative diseases (EBV-T/NK LPDs) are characterized by the transformation and proliferation of EBV-infected T or NK cells. The 2016 revised World Health Organization classification recognizes the following EBV-positive lymphoproliferative disorders (LPD): chronic active EBV infection (CAEBV) of T- and NK-cell type (cutaneous and systemic forms), systemic EBV-positive T-cell lymphoma of childhood, aggressive NK-cell leukemia, extranodal NK/T-cell lymphoma, nasal type, and the new provisional entity primary EBV-positive nodal T/NK-cell lymphoma. EBV-associated hemophagocytic lymphohistiocytosis (HLH), although not included in the WHO classification because it is a reactive, inflammatory disease, is included in this review because it can be life-threatening and may have overlapping features with other EBV+ T/NK LPDs. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00071/
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http://dx.doi.org/10.3389/fped.2019.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428722PMC
March 2019
7 Reads

Opportunities to Target the Life Cycle of Epstein-Barr Virus (EBV) in EBV-Associated Lymphoproliferative Disorders.

Front Oncol 2019 15;9:127. Epub 2019 Mar 15.

Division of Hematology, University of Colorado, Aurora, CO, United States.

Many lymphoproliferative disorders (LPDs) are considered "EBV associated" based on detection of the virus in tumor tissue. EBV drives proliferation of LPDs via expression of the viral latent genes and many pre-clinical and clinical studies have shown EBV-associated LPDs can be treated by exploiting the viral life cycle. After a brief review of EBV virology and the natural life cycle within a host we will discuss the importance of the viral gene programs expressed during specific viral phases, as well as within immunocompetent vs. Read More

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http://dx.doi.org/10.3389/fonc.2019.00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428703PMC
March 2019
2 Reads

Clinical Significance of Polymorphisms in Immune Response Genes in Hepatitis C-Related Hepatocellular Carcinoma.

Front Microbiol 2019 15;10:475. Epub 2019 Mar 15.

Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy.

Polymorphisms in the immune response genes can contribute to clearance of hepatitis C virus (HCV) infection but also mediate liver inflammation and cancer pathogenesis. This study aimed to investigate the association of polymorphisms in PD-1 (PDCD1), IFNL3 (IL28B), and TLR2 immune related genes in chronic HCV patients with different hepatic and lymphoproliferative HCV-related diseases. Selected PDCD1, IFNL3, and TLR2 genes were tested by molecular approaches in 450 HCV-positive patients with increasing severity of underlying liver diseases [including chronic infection (CHC), cirrhosis and hepatocellular carcinoma (HCC)], in 238 HCV-positive patients with lymphoproliferative diseases [such as cryoglobulinemia and non-Hodgkin lymphoma (NHL)] and in 94 blood donors (BD). Read More

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http://dx.doi.org/10.3389/fmicb.2019.00475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429030PMC
March 2019
2 Reads
3.941 Impact Factor

[Comparison of Pegfilgrastim and Filgrastim for the Primary Prophylactic Effect for Preventing Febrile Neutropenia in Patients Undergoing Rituximab with Dose-adjusted EPOCH Chemotherapy].

Yakugaku Zasshi 2019 ;139(4):629-633

Department of Pharmacy, Hiroshima University Hospital.

The combination of dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin with rituximab (DA-EPOCH-R) is used for non-Hodgkin lymphoma patients. Febrile neutropenia (FN) is a common complication of treatment with myelo-suppressive chemotherapy, so preventing FN is important for maintaining chemotherapy dosage. Recently, pegfilgrastim has been used as the primary prophylaxis of FN in Japan, but there have been few cases reported using pegfilgrastim for the primary prophylaxis in DA-EPOCH-R. Read More

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http://dx.doi.org/10.1248/yakushi.18-00101DOI Listing
April 2019
1 Read

Impact of acquisition count statistics reduction and SUV discretization on PET radiomic features in pediatric 18F-FDG-PET/MRI examinations.

Phys Med 2019 Mar 16;59:117-126. Epub 2019 Mar 16.

Medical Physics Department, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy.

Purpose: The evaluation of features robustness with respect to acquisition and post-processing parameter changes is fundamental for the reliability of radiomics studies. The aim of this study was to investigate the sensitivity of PET radiomic features to acquisition statistics reduction and standardized-uptake-volume (SUV) discretization in PET/MRI pediatric examinations.

Methods: Twenty-seven lesions were detected from the analysis of twenty-one 18F-FDG-PET/MRI pediatric examinations. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.03.005DOI Listing
March 2019
2 Reads

Myeloid disorders after autoimmune disease.

Best Pract Res Clin Haematol 2019 03 7;32(1):74-88. Epub 2019 Feb 7.

Yale University School of Medicine, Department of Medicine, Section of Hematology, New Haven, CT, USA. Electronic address:

Autoimmune diseases (ADs) are associated with an increased risk not only of lymphoproliferative disorders but also of myeloid malignancies. The excess risk of myelodysplastic syndromes and/or acute myeloid leukemia is observed across several AD types, including systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disorders, multiple sclerosis, among others. The risk of developing myeloid neoplasms (MNs) is dependent on several variables, including the specific AD type, chronicity and severity of the AD, type and duration of exposure of disease modifying anti-rheumatic drugs or cytotoxics/immunosuppressives, and genetic predisposition risk. Read More

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http://dx.doi.org/10.1016/j.beha.2019.02.002DOI Listing
March 2019
2 Reads

Response.

Vet Clin Pathol 2019 03;48(1):7-8

Oregon State University, Corvallis, Oregon.

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http://dx.doi.org/10.1111/vcp.12712DOI Listing

Chronic granulomatous pneumonia and lung rupture secondary to aspiration of activated charcoal in a French Bulldog.

Vet Clin Pathol 2019 Mar;48(1):67-70

Department of Pathology, University of Georgia, Athens, Georgia.

A 4-year-old, spayed female French Bulldog was presented for respiratory distress and suspected aspiration pneumonia after oral administration of activated charcoal for possible ingestion of a suspected toxic dose of trazodone. The patient had a moderate volume of pleural effusion, which contained free and intracellular black particulate matter consistent with charcoal. Due to presumed charcoal aspiration with subsequent lung rupture, the right middle and right caudal lung lobes were surgically removed. Read More

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http://dx.doi.org/10.1111/vcp.12700DOI Listing
March 2019
1 Read

Rare presentation of chronic ileocecal intussusception secondary to Burkitt's lymphoma in three years Sudanese boy: a case report and literature review.

Pan Afr Med J 2018 26;31:57. Epub 2018 Sep 26.

Pediatrics Department, College of Medicine, Bisha University, KSA.

A case report of chronic ileocecal intussusceptions in 3-years old Sudanese boy diagnosed as abdominal Burkett's lymphoma as leading point, who presented to his local hospital severely wasted with prolonged abdominal symptoms. Ultra sound and computed tomographic scan of his abdomen and pelvis with oral contrast confirmed intussusception. He was referred to pediatric surgical department and underwent laparotomy confirming ileocecal intussusception with resection of gangrenous part of his large and small bowel with end-to-end anastomosis. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.57.14793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431416PMC
April 2019
1 Read

Bilateral granulomatous panuveitis in two patients with T-cell type of chronic active Epstein-Barr virus infection.

BMC Ophthalmol 2019 Mar 29;19(1):83. Epub 2019 Mar 29.

Department of Ophthalmology & Visual Science Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-Ku, Tokyo, 113-8519, Japan.

Background: To report 2 cases of bilateral granulomatous panuveitis accompanied by chronic active Epstein-Barr virus infection (CAEBV).

Case Presentation: Case 1 was a 38-year-old man who had a history of bilateral mild panuveitis who was diagnosed with CAEBV. Fifteen months later, a severe bilateral granulomatous panuveitis developed. Read More

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http://dx.doi.org/10.1186/s12886-019-1090-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440096PMC
March 2019
2 Reads

Clinical characteristics and prognostic factors of primary extranodal classical Hodgkin lymphoma: a retrospective study.

Hematology 2019 Dec;24(1):413-419

a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma , Peking University Cancer Hospital & Institute , Beijing , People's Republic of China.

Objectives: To analyze the clinical characteristics and prognosis of primary extranodal classical Hodgkin lymphoma (PE-cHL).

Methods: Clinical features and outcomes of 22 PE-cHL patients who received initial chemotherapy January 2008 to January 2018 were analyzed retrospectively, and compared with 274 primary nodal Hodgkin lymphoma (PN-cHL) patients treated in the same period.

Results: With a median follow-up period of 42 months, compared with 274 PN-cHL patients, no significant difference of overall response rate (ORR) or complete remission (CR) rate was found, but the PE-cHL patients showed a higher recurrence rate (36. Read More

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http://dx.doi.org/10.1080/16078454.2019.1598678DOI Listing
December 2019
1 Read
1.189 Impact Factor

Primary hepatic mucosa-associated lymphoid tissue lymphoma: A case report and literature review.

Medicine (Baltimore) 2019 Mar;98(13):e15034

Department of Hepatobiliary Surgery, Jingjiang People's Hospital, Affiliated to Medical College of Yangzhou University, Taizhou, China.

Rationale: Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is a rare disease, and there is no consensus yet on the treatment modalities. Here, we report a new case of MALT lymphoma and review the current literature on this disease.

Patient Concerns: A 73-year-old man was admitted to our department following the incidental finding of a solitary 1. Read More

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http://dx.doi.org/10.1097/MD.0000000000015034DOI Listing
March 2019
3 Reads

[Aggressive natural killer cell leukemia: study of a case occurred in Africa and literature review].

Pan Afr Med J 2018 13;31:28. Epub 2018 Sep 13.

Service d'Hématologie CHU Mohammed VI, Marrakech, Maroc.

Aggressive natural killer cell leukemia (ANKL) is a disease entity within the spectrum of lymphoproliferative syndromes of NK cells. It is rare, preferentially affecting Asiatic people. It has been very rarely reported in the African population; hence the interest of our case. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.28.16360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430943PMC