358,314 results match your criteria Lymphoproliferative Disorders


T-Cell Large Granular Lymphocyte Leukemia in a Patient With Rheumatoid Arthritis.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620941303

Nassau University Medical Center, East Meadow, NY, USA.

Large granular lymphocyte leukemia (LGL) is a clonal, lymphoproliferative disorder with an indolent disease course. T-cell LGL (T-LGL) is the most common type of LGL driven from T-cell lineage (85%). The coexistence of T-LGL with several types of autoimmune disorders, mostly rheumatoid arthritis (RA), has been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2324709620941303DOI Listing

Sjögren Syndrome and Cancer.

Rheum Dis Clin North Am 2020 Aug;46(3):513-532

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, MS 38, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA; US Department of Veterans Affairs, Oklahoma City, OK, USA. Electronic address:

The association between malignancy and rheumatic diseases has been demonstrated in a multitude of studies. Little is understood regarding the pathogenesis of rheumatic and musculoskeletal diseases in association with malignancy. There is strong evidence regarding the association between Sjögren syndrome and lymphoma as well as risk factors for development of lymphoma in these patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rdc.2020.05.004DOI Listing

Monoclonal Gammopathies of Renal Significance: Renal Biopsy and Beyond.

Cancers (Basel) 2020 Jun 30;12(7). Epub 2020 Jun 30.

Divisions of Nephrology, General Pathology, and Pathology, Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, 00189 Rome, Italy.

Monoclonal Gammopathies of Renal Significance (MGRS) are a rather heterogeneous group of renal disorders caused by a circulating monoclonal (MC) immunoglobulin (Ig) component, often in the absence of multiple myeloma (MM) or another clinically relevant lymphoproliferative disorder. Nevertheless, substantial kidney damage could occur, despite the "benign" features of the bone-marrow biopsy. One example is renal amyloidosis, often linked to a small clone of plasma cells, without the invasive features of MM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12071741DOI Listing

The BCL-2 family protein inhibitor ABT-737 as an additional tool for the treatment of EBV-associated post-transplant lymphoproliferative disorders.

Mol Oncol 2020 Jul 4. Epub 2020 Jul 4.

UMR 8126, CNRS, Université Paris-Saclay, Institut Gustave Roussy, 94805, Villejuif, France.

Post-transplant lymphoproliferative disorders (PTLD) and Burkitt lymphoma (BL) are B-cell malignancies strongly associated with Epstein-Barr virus (EBV) infection. In these lymphoproliferative disorders, EBV infection induces an increase in the expression of the anti-apoptotic protein BCL-2. Given its chemoprotective effect, BCL-2 constitutes an attractive target for new therapeutic strategies for EBV-positive B-cell malignancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/1878-0261.12759DOI Listing

Intravascular Cutaneous Disorders. A Clinicopathologic Review.

Am J Dermatopathol 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Intravascular proliferations of the skin are clinically heterogeneous and may present with a wide range of clinical features, including violaceous papules, nodules, plaques, or other unspecific cutaneous lesions. Histopathologically, these conditions are characterized by proliferation of different cell types within the lumina of dermal vessels and endothelial cell hyperplasia. Immunohistochemistry is the best tool to identify the nature of the intravascular proliferating cells and the type of involved vessel. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DAD.0000000000001706DOI Listing

[Supratentorial Primary Central Nervous System Lymphoma with Hyperperfusion:Report of One Case].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):421-426

Department of Radiology.

We reported a case of supratentorial primary central nervous system lymphoma with hyperperfusion.Computed tomography revealed hyperdense lesions on the bilateral centrum semiovale with obvious edema.Magnetic resonance imaging demonstrated that the lesion presented slightly long and iso-T1 signal and slightly long and long T2 signals;hyperintensity was found on diffusion-weighted imaging,with relatively high apparent diffusion coefficient value compared with the adjacent normal white matter. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3881/j.issn.1000-503X.11467DOI Listing

Primary testicular T-lymphoblastic lymphoma in a child: A case report.

Medicine (Baltimore) 2020 Jun;99(26):e20861

Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University.

Rationale: Primary non-Hodgkin lymphoma (NHL) of the testes is rare, representing about 9% of testicular neoplasms and 1% to 2% of non-Hodgkin lymphomas.

Patient Concerns: A previously healthy 47-month-old boy came to our institution for 3 months unilateral testicular swelling without tenderness. After preliminary examination, inguinal orchiectomy was performed to resect the right scrotal mass. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328915PMC

Hyper-CVAD regimen in combination with ofatumumab as frontline therapy for adults with Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia: a single-arm, phase 2 trial.

Lancet Haematol 2020 Jul;7(7):e523-e533

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: The addition of rituximab to intensive chemotherapy improves outcomes in patients with B-cell acute lymphoblastic leukaemia. Ofatumumab is an anti-CD20 monoclonal antibody that binds to the small extracellular loop of CD20 and has greater in vitro complement-mediated cytotoxicity than rituximab. In this study, we assessed the activity and safety of ofatumumab in combination with chemotherapy in patients with Philadelphia chromosome (Ph)-negative CD20-positive B-cell acute lymphoblastic leukaemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2352-3026(20)30144-7DOI Listing

Selinexor in patients with relapsed or refractory diffuse large B-cell lymphoma (SADAL): a single-arm, multinational, multicentre, open-label, phase 2 trial.

Lancet Haematol 2020 Jul;7(7):e511-e522

Hospital Universitario La Paz, Madrid, Spain.

Background: Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer with a median overall survival of less than 6 months. We aimed to assess the response to single-agent selinexor, an oral selective inhibitor of nuclear export, in patients with relapsed or refractory DLBCL who had no therapeutic options of potential clinical benefit.

Methods: SADAL was a multicentre, multinational, open-label, phase 2b study done in 59 sites in 19 countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2352-3026(20)30120-4DOI Listing

Prosthetic Rehabilitation of a Patient Diagnosed With Sarcoidosis Using Dental Implants: A Clinical Case Report.

J Oral Implantol 2020 Jun;46(3):235-243

Royal London Dental Hospital, Bart's Health NHS Trust, London, United Kingdom.

No previously published studies have reported on the placement and restoration of dental implants in a patient diagnosed with sarcoidosis. Patients with sarcoidosis may develop periodontitis as a manifestation of systemic disease and are therefore at increased risk of tooth loss. These patients are likely to want fixed dental prostheses, which may need to be supported by dental implants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1563/aaid-joi-D-18-00309DOI Listing

An acute episode of inflammatory bowel disease vs a rare manifestation of an Epstein-Barr virus-positive mucocutaneous ulcer. Case report.

Rev Esp Enferm Dig 2020 Jun 24;112. Epub 2020 Jun 24.

Aparato Digestivo, Hospital Universitario de Canarias.

The Epstein-Barr virus-positive mucocutaneous ulcer is an entity that has been recently accepted in the literature, included under the lymphoproliferative disorders. Some publications provide information about a limited number of cases describing lesions that mainly involve the oropharynx and skin. However, its rapid onset in the colon, causing a perforation, has not been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17235/reed.2020.6737/2019DOI Listing

STAT3 gain-of-function mutation in a patient with pulmonary infection.

Respir Med Case Rep 2020 12;30:101125. Epub 2020 Jun 12.

University of Miami, Miller School of Medicine, Pulmonary and Critical Care Division, USA.

Background: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in cellular proliferation, apoptosis, and differentiation. Mutations in the STAT3 gene have been associated with dysregulation of the immune system giving rise to primary immunodeficiency syndromes (PID). Clinically, patients may present with very broad manifestations, and its diagnosis is usually very challenging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmcr.2020.101125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300236PMC

A population-based study on serious inpatient bacterial infections in patients with chronic lymphocytic leukemia and their impact on survival.

Eur J Haematol 2020 Jun 23. Epub 2020 Jun 23.

Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Objective: Infections in chronic lymphocytic leukemia (CLL) have been thoroughly investigated in the setting of clinical trials and single center studies. However, large cohort studies on real-world data and studies on temporal trends are lacking. We performed a nationwide study on serious bacterial infections in CLL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejh.13477DOI Listing

Lymphomatoid Papulosis With a Unique T Follicular Helper-Like Phenotype.

Am J Dermatopathol 2020 Jun 5. Epub 2020 Jun 5.

Department of Pathology, Dermatopathology Section, The University of Texas MD Anderson Cancer Center, Houston, TX.

Lymphomatoid papulosis (LyP) is a benign skin condition that typically presents with grouped or scattered lesions on the body that self-resolve within weeks or months of onset. LyP belongs to the group of CD30-positive lymphoproliferative disorders. Several histological variants of LyP exist, and the histological features of LyP can overlap with other lymphoproliferative disorders; therefore, both histological and clinical correlations are needed for a proper diagnosis of LyP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DAD.0000000000001693DOI Listing

Diagnostic relevance of 18F-FDG PET/CT in newly diagnosed patients with monoclonal gammopathy of undetermined significance (MGUS): Single-center experience.

Neoplasma 2020 Jun 23. Epub 2020 Jun 23.

Department of Internal Medicine, Hematology and Oncology, University Hospital, Masaryk University, Brno, Czech Republic.

Monoclonal gammopathy of undetermined significance (MGUS) is a known precursor of more serious cancers, such as multiple myeloma (MM), Waldenström macroglobulinemia (MW) and other lymphoproliferative disorders. Using 18F-FDG PET/CT, we aimed to evaluate its benefit in early detection of various accompanying disorders and illnesses in MGUS patients. We prospectively analyzed the diagnostic relevance of 18F-FDG PET/CT in 390 newly diagnosed MGUS patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4149/neo_2020_191104N1137DOI Listing

Plasticity of High-Density Neutrophils in Multiple Myeloma is Associated with Increased Autophagy Via STAT3.

Int J Mol Sci 2019 Jul 19;20(14). Epub 2019 Jul 19.

Department of Surgery and Medical Specialties, University of Catania, 95123 Catania, Italy.

In both monoclonal gammopathy of uncertain significance (MGUS) and multiple myeloma (MM) patients, immune functions are variably impaired, and there is a high risk of bacterial infections. Neutrophils are the most abundant circulating leukocytes and constitute the first line of host defense. Since little is known about the contribution of autophagy in the neutrophil function of MGUS and MM patients, we investigated the basal autophagy flux in freshly sorted neutrophils of patients and tested the plastic response of healthy neutrophils to soluble factors of MM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20143548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678548PMC

[Burkitt’s lymphoma of the skull calotte: a case report].

Rev Fac Cien Med Univ Nac Cordoba 2020 04 14;77(2):106-109. Epub 2020 Apr 14.

Grupo de Investigación Continental, Universidad Continental. Lima, Perú..

Introduction: Burkitt’s lymphoma is a non- Hodgkin B-cell lymphoma whose cranial location is extremely rare.

Clinical Case: The case of a 35-year-old Peruvian man with a progressive parietal left cranial tumor is described. A biopsy with immunohistochemistry was performed for the diagnostic confirmation of Burkitt’s lymphoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.31053/1853.0605.v77.n2.26764DOI Listing

Epstein-Barr Virus-negative Marginal Zone Lymphoma as an Uncommon Form of Monomorphic Posttransplant Lymphoproliferative Disorder.

Am J Surg Pathol 2020 Jun 16. Epub 2020 Jun 16.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD.

Monomorphic posttransplant lymphoproliferative disorders have been defined as lymphoid or plasmacytic proliferations that fulfill criteria for one of the B-cell or T/NK-cell neoplasms recognized in immunocompetent hosts in the current WHO Classification. Low-grade B-cell neoplasms have historically been excluded from this category, although rare reports of marginal zone lymphoma (MZL) have been described. We report 9 cases of posttransplant Epstein-Barr virus-negative MZL, all arising in solid organ transplant recipients (4 renal, 3 liver, 1 cardiac, and 1 liver, pancreas, and small bowel). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001514DOI Listing

The acquired von Willebrand syndrome focused for hematologists.

Haematologica 2020 Jun 18. Epub 2020 Jun 18.

Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy

The acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder with laboratory findings similar to those of inherited von Willebrand disease. However, unlike the inherited disease, the AVWS occurs in persons with no personal or family history of bleeding and is often associated with a variety of underlying diseases, most frequently lymphoproliferative, myeloproliferative and cardiovascular disorders. After the presentation of a typical case, in this narrative review we discuss the more recent data on the pathophysiology, clinical, laboratory and therapeutic aspects of this acquired bleeding syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2020.255117DOI Listing

Midfoot Arthritis in Children: Is There Any Relation With Malignancy?

Clin Med Insights Arthritis Musculoskelet Disord 2020 8;13:1179544120924643. Epub 2020 Jun 8.

Department of Pediatrics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Musculoskeletal symptoms are a presenting manifestation in a number of lymphoproliferative disorders including leukemia, especially in children. Among these primary symptoms, midfoot arthritis seems to be an important alarm for malignancy in children. The aim of this study is evaluation association of midfoot arthritis with malignancy in children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179544120924643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281876PMC

The use of different dialysis membranes in therapy of patients with multiple myeloma.

Polim Med 2019 Jul-Dec;49(2):67-70

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Poland.

Free light chains accumulation is the reason of kidney injury in patients with multiple myeloma. The removal of free light chains can improve patients prognosis and survival, and in some cases allows for dialysotherapy discontinuation. Unfortunately, conventional dialysis is not effective enough in terms of free light chains removal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17219/pim/122014DOI Listing

Flow cytometry in the diagnosis of mature B-cell lymphoproliferative disorders.

Int J Lab Hematol 2020 Jun;42 Suppl 1:113-120

Hematology Biology Department, Nantes University Hospital and CRCINA, Nantes, France.

B-lineage lymphoproliferative disorders (LPD) are rather frequent diseases, associated with specific clinical or biological features but also sometimes of fortuitous discovery. Multiparameter flow cytometry plays a major role for a rapid diagnostic indication, on peripheral blood or bone marrow samples in most instances, guiding complementary analyses and allowing for the proper therapeutic management of patients. After describing the important pre-analytical precautions required for an adequate assessment, the immunophenotypic features of small-cell and large-cell lymphomas are described in this review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijlh.13170DOI Listing

Chronic active Epstein-Barr virus infection: A heterogeneous entity requiring a high index of suspicion for diagnosis.

Int J Lab Hematol 2020 Jun;42 Suppl 1:99-106

Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.

Chronic active Epstein-Barr virus infection of T- and NK-cell type, systemic form, is a rare entity within the spectrum of EBV-driven T- and NK-cell lymphoproliferative disorders. Established diagnostic criteria and a characteristic clinical course help to differentiate it from other closely related EBV-positive neoplasms and clinical states. We present a patient and review the natural history, pathologic features, pathogenesis, and differential diagnosis of this entity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijlh.13199DOI Listing

The association of gene rearrangement and lymphoma diagnosis: A prospective observational study.

Medicine (Baltimore) 2020 Jun;99(24):e20733

Department of Pathology, Deyang People's Hospital, Deyang City.

Introduction: To investigate the gene rearrangement and mutation of lymphoma biomarkers including (Immunoglobulin H (IgH), Immunoglobulin kappa (IGK), Immunoglobulin lambda (IGL), and TCR) in the lymphoma diagnosis.

Methods And Analysis: Paraffin tissue samples from 240 cases diagnosed as suspected lymphoma in the department of pathology, Deyang City People's Hospital from June 2020 to June 2021 will be enrolled. Deoxyribonucleic acid extraction and Polymerase Chain Reaction (PCR) amplification will be performed in these paraffin tissue samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302616PMC

Immunodeficiency-Related Lymphoid Proliferations: New Insights With Relevance to Practice.

Curr Hematol Malig Rep 2020 Jun 13. Epub 2020 Jun 13.

Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

Purpose Of Review: Our understanding of risk factors and mechanisms underlying immunosuppression-related lymphoproliferative disorders continues to evolve. An increasing number of patients are living with altered immune status due to HIV, solid organ or hematopoietic stem cell transplant, treatment of autoimmune disease, or advanced age. This review covers advances in understanding, emerging trends, and revisions to diagnostic guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11899-020-00594-1DOI Listing

Primary effusion lymphoma metachronous to multicentric Castleman disease in an immunocompetent patient.

Pathol Res Pract 2020 Jul 20;216(7):153024. Epub 2020 May 20.

Pathology Unit, Fondazione IRCCS Ospedale 'Casa Sollievo della Sofferenza', Viale Cappuccini 1, 71013 San Giovanni Rotondo (Foggia), Italy.

Human Herpesvirus 8 (HHV8) has been associated with a wide spectrum of B-cell lymphoproliferative disorders, including Primary Effusion Lymphoma, Multicentric Castleman Disease, HHV8-positive Diffuse Large B-cell Lymphoma, not otherwise specified and germinotropic lymphoproliferative disorder. The association of different HHV8-related lymphoproliferative disorders is described in immunodeficient patients. We report a case of Primary Effusion Lymphoma metachronous to Multicentric Castleman Disease in an immunocompetent patient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prp.2020.153024DOI Listing

FMOD expression in whole blood aids in distinguishing between chronic lymphocytic leukemia and other leukemic lymphoproliferative disorders. A pilot study.

Cytometry B Clin Cytom 2020 Jun 12. Epub 2020 Jun 12.

Hematology Laboratory, ICO-Hospital Germans Trias i Pujol, Institut de Recerca Josep Carreras, Universitat Autònoma de Barcelona, Badalona, Spain.

Background: Within the hematopoietic compartment, fibromodulin (FMOD) is almost exclusively expressed in chronic lymphocytic leukemia (CLL) lymphocytes. We set out to determine whether FMOD could be of help in diagnosing borderline lymphoproliferative disorders (LPD).

Methods: We established 3 flow cytometry-defined groups (CLL [n = 65], borderline LPD [n = 28], broadly defined as those with CLLflow score between 35 and -20 or discordant CD43 and CLLflow, and non-CLL LPD [n = 40]). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cyto.b.21890DOI Listing
June 2020
2.283 Impact Factor

HHV8-positive, EBV-positive Hodgkin lymphoma-like large B cell lymphoma: expanding the spectrum of HHV8 and EBV-associated lymphoproliferative disorders.

Int J Hematol 2020 Jun 11. Epub 2020 Jun 11.

Hematopathology Unit, Department of Pathology, Hospital Clinic of Barcelona, Barcelona, Spain.

Human herpesvirus type 8 (HHV8) is a gamma herpesvirus known for its role in lymphoid neoplasms, especially in immunosuppressed patients. We describe the case of a 64-year-old male, without known immunodeficiency, with 1-year-long clinical history of mediastinal and abdominal lymphadenopathies and recurrent pulmonary infections. Histopathological evaluation of a mediastinal lymph node revealed the presence of scattered atypical large cells with Hodgkin and Reed-Sternberg morphology in a background of lymphocytes and extensive areas of fibrosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12185-020-02897-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287409PMC

A Rare Association: Autoimmune Hemolytic Anemia With Indolent T-Cell Prolymphocytic Leukemia.

Cureus 2020 May 6;12(5):e7994. Epub 2020 May 6.

Pathology/Hematopathology, Fox Chase Cancer Center, Philadelphia, USA.

The association of warm autoimmune hemolytic anemia (wAIHA) with various lymphoproliferative disorders is well reported in the literature. But the association of wAIHA with T-cell prolymphocytic leukemia (T-PLL), a very rare lymphoproliferative disorder, has never been reported. A 71-year-old man was in his usual state of health until three years ago when he developed intermittent bouts of worsening anemia associated with mild peripheral blood lymphocytosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274264PMC

Brief annotations on cytokine release syndrome and interleukin-6 therapeutic blockage in SARS-CoV-2/COVID-19.

Arch Cardiol Mex 2020 ;90(Supl):84-87

Departamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24875/ACM.M20000067DOI Listing

Extranasal extranodal NK/T-cell lymphoma associated with systemic lupus erythematosus.

Int J Hematol 2020 Jun 8. Epub 2020 Jun 8.

Department of Hematology, Tohoku University Hospital, 1-1 Seiryo-cho, Sendai, 980-8574, Japan.

Increased incidence of lymphoproliferative disorders is reported in patients with autoimmune diseases, majority of which have a B-cell phenotype and are pathogenetically associated with the reactivation of Epstein-Barr virus (EBV). However, EBV-associated T/NK-cell lymphoma has hardly been reported. We present the case of a 68-year-old-woman, who had been diagnosed with systemic lupus erythematosus (SLE) 28 years back and was treated with various immunosuppressive agents including steroids, cyclophosphamide, and tacrolimus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12185-020-02914-wDOI Listing

Co-occurrence between C1 esterase inhibitor deficiency and autoimmune disease: a systematic literature review.

Allergy Asthma Clin Immunol 2020 27;16:41. Epub 2020 May 27.

CSL Behring, Marburg, Germany.

Background: Hereditary angioedema (HAE) is caused by a SERPING1 gene defect resulting in decreased (Type I) or dysfunctional (Type II) C1 esterase inhibitor (C1-INH). The prevalence of autoimmune diseases (ADs) in patients with HAE appears to be higher than the general population. A systematic literature review was conducted to examine the co-occurrence between HAE and ADs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13223-020-00437-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254644PMC

A Multi-Institutional Validation of the Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Patients With Diffuse Large B-Cell Lymphoma: A Study From The Latin American Group of Lymphoproliferative Disorders (GELL).

Clin Lymphoma Myeloma Leuk 2020 May 4. Epub 2020 May 4.

Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. Electronic address:

Introduction: We aimed at investigating the prognostic role of the neutrophil-to-lymphocyte ratio (NLR) in 2 independent cohorts of Latin American patients with diffuse large B-cell lymphoma (DLBCL) treated with chemoimmunotherapy.

Patients And Methods: The learning cohort was composed of 274 patients and the validation cohort of 323 patients, for a total of 597 patients. An optimal NLR cutoff ≥ 4 was determined using receiver operating characteristic analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clml.2020.04.016DOI Listing

Sclerodermalike syndromes: Great imitators.

Clin Dermatol 2020 Mar - Apr;38(2):235-249. Epub 2019 Oct 24.

Department of Rheumatology and Immunology, University of Pécs Clinical Center, Pecs, Hungary. Electronic address:

Sclerodermalike syndromes (SLSs) comprise diseases with mucin deposition (eg, scleromyxedema, scleredema), with eosinophilia (eg, eosinophilic fasciitis), metabolic or biochemical abnormalities (eg, nephrogenic systemic fibrosis), or endocrine disorders (eg, POEMS syndrome, or polyneuropathy, organomegaly, endocrinopathy, monoclonal lymphoproliferative disorder, and hypothyroidism). Chronic graft-versus-host disease may also show sclerodermalike skin changes. Inherited progeria syndromes with early aging (eg, Werner syndrome) and a heterogeneous group of hereditary disorders with either skin thickening (eg, stiff skin syndrome) or atrophy and tightening (eg, acrogeria) can also imitate classic systemic sclerosis (SSc). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clindermatol.2019.10.010DOI Listing
October 2019

Tolerization of recent thymic emigrants is required to prevent RBC-specific autoimmunity.

J Autoimmun 2020 Jun 2:102489. Epub 2020 Jun 2.

Columbia University Irving Medical Center, Department of Pathology and Cell Biology, New York, NY, USA. Electronic address:

Autoimmune hemolytic anemia (AIHA) leads to accelerated destruction of autologous red blood cells (RBCs) by autoantibodies. AIHA is a severe and sometimes fatal disease. While there are several therapeutic strategies available, there are currently no licensed treatments for AIHA and few therapeutics result in treatment-free durable remission. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2020.102489DOI Listing

Type II enteropathy-associated T cell lymphoma in the duodenum: A rare case report.

Medicine (Baltimore) 2020 Jun;99(23):e20050

Department of Gastroenterological Surgery.

Introduction: Enteropathy-associated T-cell lymphoma (EATL) is a very rare form of lymphoma in the gastrointestinal tract. The proximal jejunum and ileum are the most common sites of EATL, whereas EATL rarely arises in the duodenum, and EATL involving metastasis of the bilateral ovaries is even rarer.

Patient Concerns: A 43-year-old female suffered from upper abdominal pain and weight loss for 3 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306349PMC
June 2020
5.723 Impact Factor

Productive herpesvirus lytic replication in primary effusion lymphoma cells requires S-phase entry.

J Gen Virol 2020 Jun 5. Epub 2020 Jun 5.

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.

Gammaherpesviruses establish lifelong latent infection in B lymphocytes and are the causative agent of several B-cell malignancies and lymphoproliferative disorders. While a quiescent latent infection allows these pathogens to evade immune detection, initiation of an alternative lifecycle stage, known as lytic replication, is an essential step in the production and dissemination of infectious progeny. Although cessation of cellular proliferation is an eventual consequence of lytic induction, exactly how gammaherpesviruses manipulate the cell cycle prior to amplification of viral DNA remains under debate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/jgv.0.001444DOI Listing

[Circular resection of the thoracic trachea for MALT lymphoma in an 81-year-old patient].

Khirurgiia (Mosk) 2020 (5):96-99

Tomsk Regional Clinical Hospital, Tomsk, Russia.

A rare clinical observation of primary tracheal MALT lymphoma is reported and difficulties of differential diagnosis are discussed. Tracheal neoplasms are rare tumors and characterized by delayed diagnosis after clinical manifestation (tracheal stenosis and associated complications). These tumors often occur an advanced age patients that complicates examination and surgical treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/hirurgia202005196DOI Listing

A tissue level atlas of the healthy human virome.

BMC Biol 2020 Jun 4;18(1):55. Epub 2020 Jun 4.

Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 1088639, Japan.

Background: Human-resident microbes can influence both health and disease. Investigating the microbiome using next-generation sequencing technology has revealed examples of mutualism and conflict between microbes and humans. Comparing to bacteria, the viral component of the microbiome (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12915-020-00785-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269688PMC

Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.

N Engl J Med 2020 06;382(23):2207-2219

From the Departments of Pediatric and Adolescent Oncology (V.M.-C., C.P.) and Clinical Research (G.V.), INSERM Unité 1015 (V.M.-C.), and the Unit of Biostatistics and Epidemiology and INSERM Unité 1018 (A.A.), Gustave Roussy, Université Paris-Saclay, Villejuif, France; the Department of Pediatric Hematology and Oncology, University of Padua, Padua, Italy (M.P.); the Department of Paediatric Haematology, Oncology, and Palliative Care, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge (G.A.A.B.), Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham (K.W.), and the Department of Histopathology, Royal Marsden NHS Foundation Trust, London (A.W.) - all in the United Kingdom; the Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles (D.A.B.); the Department of Pediatric Hematology and Oncology, University of Valencia, Valencia, Spain (R.F.D.); the Division of Haematology-Oncology, Hospital for Sick Children, Toronto (S.A.); the Department of Pediatric Hematology and Oncology, University Hospitals Leuven, Leuven, Belgium (A.U.); the Center for Cancer and Immunology Research, Children's National Health System and George Washington University, Washington, DC (C.M.B.); Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands (J.Z.); the Department of Pediatric Hematology and Oncology, Semmelweis University, Budapest, Hungary (M.C.); the Department of Pediatric Bone Marrow Transplantation, Oncology, and Hematology, Wroclaw Medical University, Wroclaw, Poland (B.K.); the Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong (A.K.C.); the Department of Pathology, University of Utah, Salt Lake City (R.R.M.); Children's Hospital of Philadelphia, Philadelphia (P.C.A.); and the National Cancer Institute, Center for Global Health, Rockville, MD (T.G.G.).

Background: Rituximab added to chemotherapy prolongs survival among adults with B-cell cancer. Data on its efficacy and safety in children with high-grade, mature B-cell non-Hodgkin's lymphoma are limited.

Methods: We conducted an open-label, international, randomized, phase 3 trial involving patients younger than 18 years of age with high-risk, mature B-cell non-Hodgkin's lymphoma (stage III with an elevated lactate dehydrogenase level or stage IV) or acute leukemia to compare the addition of six doses of rituximab to standard lymphomes malins B (LMB) chemotherapy with standard LMB chemotherapy alone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1915315DOI Listing
June 2020
55.873 Impact Factor

Immunosuppression therapy is effective for both acquired tumor-associated and primary pure red cell aplasia: a match pair case-control study.

Ann Hematol 2020 Jul 1;99(7):1485-1491. Epub 2020 Jun 1.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

No agreement had been reached on the treatment of patients with pure red cell aplasia (PRCA) secondary to indolent malignancies. Data was collected from patients with acquired PRCA from May, 2014 to May, 2018 in Peking Union Medical College Hospital. Tumor-associated PRCA and primary PRCA patients were matched at a ratio of 1:2 with compatible baseline characteristics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-020-04105-3DOI Listing
July 2020
2.634 Impact Factor

Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-κB Pathways.

Anticancer Res 2020 Jun;40(6):3155-3161

Department of Laboratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Background/aim: The deacetylase sirtuin1 (SIRT1) inhibits tumor suppressor p53 and may promote tumorigenesis; however, SIRT1 effects on leukemia cells are controversial. The aim of this study was to clarify the activity of SIRT1 in leukemia cells.

Materials And Methods: The effects of SIRT1 inhibition or activation and SIRT1 knockdown or overexpression were examined in two T cell acute lymphoblastic leukemia (T-ALL) cell lines carrying NOTCH1 mutations and three acute myeloid leukemia (AML) cell lines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.14297DOI Listing

Six Candidate miRNAs Associated With Early Relapse in Pediatric B-Cell Acute Lymphoblastic Leukemia.

Anticancer Res 2020 Jun;40(6):3147-3153

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.

Background/aim: Few studies have evaluated the role of miRNAs in pediatric acute lymphoblastic leukemia (ALL) relapse and a consensus of a clinically significant miRNA signature is yet to be identified. In this study, we evaluated miRNAs associated with pediatric B-ALL early relapse in two independent sample sets.

Materials And Methods: We performed global miRNA profiling on diagnostic bone marrow specimens from six early relapse (≤3 years after diagnosis) and six age- and cytogenetics-matched prolonged remission (≥4 years) patients (first set) and an independent set of 14 early relapse and 14 matched prolonged remission specimens (second set). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.14296DOI Listing

[Whole exome sequencing and analysis of a Chinese family with familial pulmonary sarcoidosis].

Zhonghua Jie He He Hu Xi Za Zhi 2020 Jun;43(6):525-531

Department of Pulmonary Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To analyze the clinical features and the results of the whole exome sequencing (WES) of a Chinese family containing both pulmonary sarcoidosis patients and healthy members, and to find potent genes and variants that may be involved in the pathogenesis of sarcoidosis. Three patients with pulmonary sarcoidosis and 1 healthy member was included from a Chinese Han family in the north of China diagnosed in November 2016, which characterized as 2 consecutive generations including 2 males and 1 female, aged from 23 to 69 years old. The proband is Ⅱ-6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112147-20191114-00759DOI Listing

[Mediastinal T lymphoblastic lymphoma/leukemia: clinicopathological and prognostic analyses of 61 cases].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):601-606

Department of Pathology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the clinicopathologic features and prognosis of mediastinal T lymphoblastic lymphoma/leukemia (T-LBL/ALL). Sixty-one patients with mediastinal T-LBL/ALL diagnosed at First Affiliated Hospital of Zhengzhou University from August 1, 2011 to December 31, 2018 were enrolled. Their clinical, pathological, imaging features and prognosis were retrospectively analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112151-20190929-00538DOI Listing

[Expression of CDK6 and FOXM1 in peripheral T-cell lymphoma and their significance].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):594-600

Cancer Prevention and Treatment Institute, Yangquan 045000, China.

To investigate the expression of CDK6 and FOXM1 in peripheral T-cell lymphoma (PTCL), and its correlation with clinicopathologic features and patient prognosis. The Oncomine was used for data mining and analyzing the expression levels of CDK6 and FOXM1 in PTCL. Immunohistochemistry (IHC) of EnVision method was used to detect the expression of CDK6 and FOXM1 proteins in 166 cases of PTCL diagnosed at Shanxi Provincial Cancer Hospital from January 2016 to December 2018, and 30 cases of lymph node with reactive hyperplasia as control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112151-20191104-00710DOI Listing

Novel aspects on gonadotoxicity and fertility preservation in lymphoproliferative neoplasms.

Crit Rev Oncol Hematol 2020 Jul 15;151:102981. Epub 2020 May 15.

Haematology Unit, National Cancer Center, IRCCS Istituto Tumori "Giovanni Paolo II", viale O. Flacco 65, Bari, Italy. Electronic address:

The topic of fertility preservation in patients with a lymphoproliferative disease offers new aspects of debate, due to the introduction of novel chemotherapeutic regimens and small molecules in the clinical landscape. Cancer related infertility is mostly dependent on gonadotoxic treatments and fertile female patients are today addressed to the oocyte cryopreservation or to ovarian cortex fragment cryopreservation. These methods present advantages and disadvantages, which will be discussed in the present review, together with the options for male patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.critrevonc.2020.102981DOI Listing

[Acute myocarditis caused by anti-PD-1 monoclonal antibody in the treatment of refractory Hodgkin lymphoma: a case report].

Zhonghua Zhong Liu Za Zhi 2020 05;42(5):424-425

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112152-112152-20190305-0012DOI Listing