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    1 OF 17

    Oral Lymphomatoid papulosis type C: A diagnostic pitfall, often confused with T-cell lymphoma.
    Ann Diagn Pathol 2017 Dec 16;31:50-55. Epub 2017 Jun 16.
    Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address:
    Eosinophilic ulcer of the oral mucosa (EUOM) is a rare, benign, self-resolving lymphoproliferative disorder, which typically presents with asymptomatic to mildly tender ulcers. Histological findings of EUOM are characterized by a polymorphic infiltrate with many eosinophils often extending into the underlying muscle. Although this entity is well documented within the dental literature, it is not well known to physicians. Read More

    An unusual case of lymphomatoid papulosis type E with extensive necrosis.
    Indian J Dermatol Venereol Leprol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Pathology, Hospital Ramon Y Cajal, Madrid, Spain.
    Lymphomatoid papulosis type E (LyP) is a recently described subtype of LyP characterized by an angioinvasive infiltrate of atypical lymphocytes expressing CD30. We present a case of type E LyP with extensive cutaneous necrosis in the histopathological evaluation which was misdiagnosed as an ulcerative form of bacterial skin infection. The remarkable cutaneous necrosis showed in our case might be related to the angiodestructive infiltrate that was present in this circumstance. Read More

    First-line treatment in lymphomatoid papulosis: a retrospective multicentre study.
    Clin Exp Dermatol 2017 Oct 10. Epub 2017 Oct 10.
    Department of Dermatology, Hospital Clínico, University of Barcelona, IDIBAPS, Barcelona, Spain.
    Background: Data regarding response to treatment in lymphomatoid papulosis (LyP) are scarce.

    Aim: To assess the daily clinical practice approach to LyP and the response to first-line treatments.

    Methods: This was a retrospective study enrolling 252 patients with LyP. Read More

    Brentuximab Vedotin for Patients With Refractory Lymphomatoid Papulosis: An Analysis of Phase 2 Results.
    JAMA Dermatol 2017 Oct 4. Epub 2017 Oct 4.
    Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston.
    Importance: Brentuximab vedotin is a monomethyl auristatin E-conjugated monoclonal antibody directed against CD30. It represents a potential treatment for the CD30+ lymphoproliferative disorder lymphomatoid papulosis (LyP), which currently has no approved treatment.

    Objective: To assess the efficacy and safety of brentuximab vedotin for the treatment of LyP. Read More

    CD30+ T cell enriched primary cutaneous CD4+ small/medium sized pleomorphic T cell lymphoma: A distinct variant of indolent CD4+ T cell lymphoproliferative disease.
    Ann Diagn Pathol 2017 Oct 27;30:52-58. Epub 2017 Apr 27.
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA.
    Primary cutaneous CD4+ small/medium sized pleomorphic T-cell lymphoma (SMPTCL) is unique among the peripheral T-cell lymphomas because of its indolent nature, typically presenting as a solitary nodule or plaque in the head and neck area of middle-aged and older adults. Recent studies have suggested a follicular helper cell origin for these lesions.

    Materials And Methods: A retrospective review was conducted on all cases of SMPTCL diagnosed between 2008 and 2017. Read More

    A Case of Lymphomatoid Papulosis Type E With an Unusual Exacerbated Clinical Course.
    Am J Dermatopathol 2017 Sep 12. Epub 2017 Sep 12.
    *Department of Dermatology, Medical Military Academy, Saint Petersburg, Russia; and †Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
    Lymphomatoid papulosis (LyP) type E is a recently delineated variant characterized by the occurrence of large necrotic "eschar"-like lesions displaying microscopically angioinvasive and angiodestructive infiltrates composed of CD30 lymphocytes, frequently coexpressing CD8. In contrast to other LyP variants where patients develop multiple lesions, most patients with LyP type E present with few lesions (often 1 or 2 at a given time). In this article, we describe a 34-year-old man with LyP type E with an exacerbated clinical course characterized by the occurrence of almost a hundred of lesions. Read More

    [Lymphomatoid papulosis: a clinicopathologic analysis and whole exome sequencing].
    Zhonghua Bing Li Xue Za Zhi 2017 Sep;46(9):601-606
    Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu 610041, China.
    Objective: To study the clinicopathologic characteristics and immunophenotype of lymphomatoid papulosis(LyP), followed by exon mutation analysis with focus on gene mutations involved in apoptosis pathway and other possible pathogenic genes. Methods: Clinical data analysis and immunohistochemical staining were carried out in 20 cases of LyP. Whole exome sequencing technology was employed in 2 cases of type C of LyP. Read More

    Hepatitis E virus-induced primary cutaneous CD30(+) T cell lymphoproliferative disorder.
    J Hepatol 2017 Aug 30. Epub 2017 Aug 30.
    Université Paris Descartes-Sorbonne Paris Cité, Paris, France; Institut National de la Santé et de la Recherche Médicale Unité 1163, Centre National de la Recherche Scientifique, Equipes de Recherche Labellisées 8254, Institut Imagine, Paris, France; Assistance Publique-Hopitaux de Paris (AP-HP), Hôpital Necker - Enfants Malades, Haematology Service, Paris, France.
    Background & Aim: Several types of unexplained extra-hepatic manifestations, including haematological disorders, have been reported in the context of hepatitis E virus (HEV) infection. However, the underlying mechanism(s) of these manifestations are unknown. We provide evidence that HEV has an extra-hepatic endothelial tropism that can engage cutaneous T cells towards clonality. Read More

    [WHO classification and clinical spectrum of cutaneous lymphomas].
    Hautarzt 2017 Sep;68(9):682-695
    Universitätsklinik für Dermatologie, Venerologie, Allergologie und Phlebologie, Mühlenkreiskliniken, Minden, Deutschland.
    Background: Cutaneous lymphomas are rare skin cancers with a wide clinical spectrum.

    Objective: To give an overview of the current classification and the clinical spectrum of cutaneous lymphomas.

    Material And Methods: Analysis and summary of the current literature concerning the different entities of cutaneous lymphomas. Read More

    Brentuximab vedotin therapy for CD30-positive cutaneous T-cell lymphoma: a targeted approach to management.
    Future Oncol 2017 Aug 14. Epub 2017 Aug 14.
    Dermatology - University Hospitals Birmingham NHS Foundation Trust, University Hospital Birmingham, Birmingham, B15 2TH, UK.
    CD30-positive primary cutaneous T-cell lymphoma (CTCL) includes mycosis fungoides, anaplastic large-cell lymphoma and lymphomatoid papulosis type A. Brentuximab vedotin (BV) consists of an antibody targeting CD30 with a protease-cleavable linker to vedotin. CD30 binding allows internalization of BV inducing cell-cycle arrest and apoptosis. Read More

    Cutaneous T-cell Lymphoma.
    Clin Lab Med 2017 Sep;37(3):527-546
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:
    Cutaneous T-cell lymphomas comprise a heterogeneous group of diseases characterized by monoclonal proliferations of T lymphocytes primarily involving skin, modified skin appendages, and some mucosal sites. This article addresses the basic clinical, histologic, and immunohistochemical characteristics of this group of diseases, with additional attention to evolving literature on dermoscopy, reflectance confocal microscopy, flow cytometry, and molecular data that may increasingly be applied to diagnostic and therapeutic algorithms in these diseases. Select unusual phenotypes or diagnostic examples of classic phenotypes are demonstrated, and flags for consideration while making a pathologic diagnosis of cutaneous T-cell lymphoma are suggested. Read More

    Upregulation of inhibitory signaling receptor programmed death marker-1 (PD-1) in disease evolution from cutaneous lymphoid dyscrasias to mycosis fungoides and Sezary's syndrome.
    Ann Diagn Pathol 2017 Jun 10;28:54-59. Epub 2017 Feb 10.
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY 10065, USA. Electronic address:
    Background: Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but the expression profile of PD-1 and mycosis fungoides (MF) remains largely to be characterized. Read More

    Associated Hematolymphoid Malignancies in Patients With Lymphomatoid Papulosis: A Canadian Retrospective Study.
    J Cutan Med Surg 2017 Nov/Dec;21(6):507-512. Epub 2017 Jun 14.
    1 Division of Dermatology, University of Toronto, Toronto, ON, Canada.
    Background: Lymphomatoid papulosis is one of the primary cutaneous CD30+ T-cell lymphoproliferative disorders. Although considered a benign disease, lymphomatoid papulosis has been associated potentially with an increased risk of secondary hematolymphoid malignancies.

    Objective: The aim of this study was to assess the clinical characteristics and histologic subtypes of lymphomatoid papulosis, identify the prevalence and types of secondary hematolymphoid malignancies, and determine the potential risk factors for development of these hematolymphoid malignancies. Read More

    Primary Cutaneous Small Cell Variant of Anaplastic Large Cell Lymphoma: A Case Series and Review of the Literature.
    Am J Dermatopathol 2017 May 22. Epub 2017 May 22.
    *Professor of Pathology, Pathologist and Dermatopathologist, Director of Dermatopathology Division, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY; †Dermatopathology Fellow, Memorial Sloan Kettering Cancer Center/Weill Cornell Medicine, New York, NY; and ‡Assistant Professor of Clinical Dermatology, Department of Dermatology, UCDAVIS Health Center, Sacramento, CA.
    Primary cutaneous anaplastic large cell lymphoma (ALCL), similar to systemic ALCL, has as its histomorphologic hallmarks cohesive sheets of large lymphoid cells expressing CD30. Several morphologic variants of systemic ALCL have been reported, including the common (classic) type, lymphohistiocytic, and small cell variants. The small cell variant of ALCL is characterized by a predominant cytomorphology which is unexpected for ALCL, being in the context of a small- to medium-sized hyperchromatic atypical lymphocyte. Read More

    Lymphomatoid papulosis associated with chronic lymphocytic leukemia/small lymphocytic lymphoma: 3 cases.
    Br J Dermatol 2017 Jun 1. Epub 2017 Jun 1.
    Department of Dermatology, AP-HP, St Louis Hospital, Paris 7 University, Paris, France.
    Lymphomatoid papulosis (LyP) is considered as an indolent CD30+ lymphoproliferative cutaneous disorder. (1,2) Nevertheless, 10%-20% up to 50% of patients with LyP have coexistent lymphoma. (1, 3-7) The most frequently associated malignancies are mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, or Hodgkin's disease. Read More

    A Severe Case of Lymphomatoid Papulosis Type E Successfully Treated with Interferon-Alfa 2a.
    Case Rep Dermatol Med 2017 30;2017:3194738. Epub 2017 Apr 30.
    Dermatology and Venereology Department, Akdeniz University Faculty of Medicine, Antalya, Turkey.
    Lymphomatoid papulosis (LyP) is a benign papulonodular skin eruption with histologic features of malignant lymphoma. A new variant of LyP which was termed "type E" was recently described with similar clinical and histological features to angiocentric and angiodestructive T-cell lymphoma. LyP type E is characterized with recurrent papulonodular lesions which rapidly turn into hemorrhagic necrotic ulcers and spontaneous regression by leaving a scar. Read More

    Disseminated CD8-positive, CD30-positive cutaneous lymphoproliferative eruption with overlapping features of mycosis fungoides and primary cutaneous anaplastic large cell lymphoma following remote solitary lesional presentation.
    J Cutan Pathol 2017 Aug 13;44(8):703-712. Epub 2017 Jun 13.
    Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
    CD8-positive, CD30-positive cutaneous lymphoproliferative disorders constitute a rare subset of T-cell lymphoproliferative conditions, including variants of primary cutaneous anaplastic large cell lymphoma (ALCL), mycosis fungoides, lymphomatoid papulosis type D, cutaneous gamma-delta T-cell lymphoma and cutaneous peripheral T-cell lymphoma. These entities share overlapping clinical, histopathologic and immunophenotypic features, presenting both a clinical and pathological diagnostic challenge. Presented here is a 73-year-old man with a disseminated, indolent CD30+, CD8+ cutaneous lymphoproliferative disorder with overlapping clinical and histopathological features of both mycosis fungoides and primary cutaneous ALCL, as well as features of lymphomatoid papulosis. Read More


    Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas.
    Oncoimmunology 2017 10;6(3):e1273310. Epub 2017 Feb 10.
    Department of Dermatology and Allergology, University of Helsinki and Helsinki University Central Hospital , Helsinki, Finland.
    Indoleamine 2,3-deoxygenase 1 (IDO1) induces immune tolerance in the tumor microenvironment (TME) and is recognized as a potential therapeutic target. We studied the expression of both IDO1 and the related tryptophan 2,3-dioxygenase (TDO) in several different subtypes of cutaneous T-cell lymphoma (CTCL), and evaluated the kynurenine (KYN) pathway in the local TME and in patient sera. Specimens from the total of 90 CTCL patients, including mycosis fungoides (MF, n = 37), lymphomatoid papulosis (LyP, n = 36), primary cutaneous anaplastic large cell lymphoma (pcALCL, n = 4), subcutaneous panniculitis-like T-cell lymphoma (SPTCL n = 13), and 10 patients with inflammatory lichen ruber planus (LRP), were analyzed by immunohistochemistry (IHC), immunofluorescence (IF), quantitative PCR, and/or liquid chromatography-tandem mass spectrometry (LC-MS/MS). Read More

    Imatinib Treatment of Lymphomatoid Papulosis Associated with Myeloproliferative Hypereosinophilic Syndrome Presenting the FIP1L1-PDGFRA Fusion Gene.
    Acta Derm Venereol 2017 Jul;97(7):855-857
    Department of Dermatology, Universitat Autònoma de Barcelona, Hospital del Mar-Parc de Salut Mar, Passeig Marítim 25-29, ES-08003 Barcelona, Spain.

    Primary cutaneous anaplastic large cell lymphoma.
    J Cutan Pathol 2017 Jun 25;44(6):570-577. Epub 2017 Apr 25.
    Department of Pathology, Stanford University School of Medicine, Stanford, California.
    Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a CD30+ lymphoproliferative disorder (LPD) of the skin with a relatively good prognosis in the absence of high-stage disease. CD30+ LPDs comprise approximately 25%-30% of primary cutaneous lymphomas and as a group represent the second most common clonal T-cell neoplasm of the skin behind mycosis fungoides. Diagnosis of PC-ALCL relies strongly on clinicopathologic correlation given the potential morphologic, clinical and molecular overlap with the other cutaneous CD30+ LPD, lymphomatoid papulosis, and more aggressive hematolymphoid neoplasms. Read More

    CD30(+) Lymphoproliferative Disorders of the Skin.
    Hematol Oncol Clin North Am 2017 Apr;31(2):317-334
    Department of Dermatology, The Center for Cutaneous Oncology, Dana Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA. Electronic address:
    Primary cutaneous CD30(+) lymphoproliferative disorders encompass lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma (pcALCL), and indeterminate cases. LyP is a benign disorder characterized by recurrent crops of red or violaceous papulonodules. Patients with LyP are at an increased risk of a secondary malignancy. Read More

    Lymphomatoid papulosis - making sense of the alphabet soup: a proposal to simplify terminology.
    J Dtsch Dermatol Ges 2017 Apr 2;15(4):390-394. Epub 2017 Mar 2.
    IPOLFG - Serviço de Anatomia Patológica, Lissabon, Portugal.
    Clinically, lymphomatoid papulosis (LYP) is characterized by recurrent papulonodular lesions. Unlike this stereotypical clinical presentation, the histological spectrum of LYP is very wide, comprising distinct growth patterns, variably sized neoplastic cells, and different immunophenotypes. The revised 2016 WHO classification includes the histological LYP types A to E as well as another type characterized by a specific chromosomal alteration. Read More

    CD30-positive cutaneous lymphoma: report of four cases with an emphasis on clinicopathological correlations.
    An Bras Dermatol 2017 Jan-Feb;92(1):86-91
    Hospital Federal de Bonsucesso - Bonsucesso (RJ), Brazil.
    The classification of cutaneous lymphomas is multidisciplinary and requires the correlation between clinical, histopathological, immunohistochemical, and molecular diagnostic elements. In this article, we present four different cases of CD30-positive T-cell lymphoma with cutaneous manifestations. We compare cases with definitive diagnosis of papulosis lymphomatoid type C, primary cutaneous anaplastic large T-cell lymphoma, systemic anaplastic large T-cell lymphoma with secondary skin involvement, and mycosis fungoides with large cell transformation, highlighting the importance of clinicopathological correlation to classify these cases. Read More

    Aggressive cutaneous T-cell lymphomas.
    Semin Diagn Pathol 2017 Jan 24;34(1):44-59. Epub 2016 Dec 24.
    Ackerman Academy of Dermatopathology, 145 East 32nd, St 10th floor, New York, 10016, NY, USA. Electronic address:
    Cutaneous T cell lymphomas (CTCLs) are heterogeneous, with a prognosis determined in large part by combined clinical, histopathologic, and immunophenotypic features. They are classified under the WHO-EORTC classification of primary cutaneous lymphoma. Whether or not a patient diagnosed with CTCL will experience an aggressive course may not be completely predictable; however, certain subtypes have been proven to be associated with a poor response to therapy and/or short survival. Read More

    Follicular lymphomatoid papulosis with follicular mucinosis: a clinicopathologic study of 3 cases with literature review and conceptual reappraisal.
    J Cutan Pathol 2017 Apr 16;44(4):360-366. Epub 2017 Jan 16.
    Department of Dermatology, University of Iowa, Iowa City, Iowa.
    Lymphomatoid papulosis (LyP), characterized by recurring, waxing and waning, cutaneous papulonodules, is increasingly recognized to represent a heterogeneous collection of pathologically dissimilar subtypes. Recently, a follicular LyP variant was proposed, featuring folliculotropism. Folliculotropism by atypical lymphocytes is conventionally associated with follicular mucinosis and mycosis fungoides (MF), and review of the literature suggests co-occurrence of folliculotropism and follicular mucinosis in LyP to be rare, with only 3 cases identified to date. Read More

    A new era for cutaneous CD30-positive T-cell lymphoproliferative disorders.
    Semin Diagn Pathol 2017 Jan 29;34(1):22-35. Epub 2016 Nov 29.
    Kempf und Pfaltz, Histologische Diagnostik, Zürich, Switzerland; Department of Dermatology, University Hospital Zurich, CH-8091, Zurich, Switzerland. Electronic address:
    Cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ T-LPD) represent a spectrum encompassing lymphomatoid papulosis (LyP), primary cutaneous anaplastic large-cell lymphoma (pcALCL) and borderline lesions. They share the expression of CD30 as a common phenotypic marker. They differ however in their clinical presentation, the histological features and clinical course. Read More

    Past, present and future of cutaneous lymphomas.
    Semin Diagn Pathol 2017 Jan 28;34(1):3-14. Epub 2016 Nov 28.
    Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria. Electronic address:
    Primary cutaneous lymphomas represent a broad group of diseases with different clinical, histopathological, phenotypic, molecular, and prognostic features. All cutaneous lymphomas share the same tropism of neoplastic lymphocytes for the skin, but precise classification is paramount for proper management of the patients. Primary cutaneous lymphomas are classified according to the schemes proposed by the European Organization for Research and Treatment of Cancer (EORTC)-Cutaneous Lymphomas Task Force together with the World Health Organization (WHO) in 2005, and the WHO classification of 2008 with the 2016 update. Read More

    Cutaneous lymphoma: Kids are not just little people.
    Clin Dermatol 2016 Nov - Dec;34(6):749-759. Epub 2016 Jul 10.
    Department of Dermatology, University of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT 06030.
    Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin lymphomas that predominantly affect older patients. Onset of cutaneous lymphoma in childhood is rare, but it can present as early as the first decade of life. In both adults and children, the diagnosis of cutaneous lymphoma can be challenging because inflammatory dermatoses can mimic CTCL both clinically and histologically. Read More

    Lymphoma of the eyelid.
    Surv Ophthalmol 2017 May - Jun;62(3):312-331. Epub 2016 Nov 26.
    Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address:
    Lymphoma of the eyelid constitutes 5% of ocular adnexal lymphoma. In previously published cases, 56% of lymphomas of the eyelid are of B-cell origin and 44% are of T-cell origin. The most frequent B-cell lymphomas are extranodal marginal zone lymphoma (27 cases-14%) and diffuse large B-cell lymphoma (18 cases-9%). Read More

    Low-dose radiotherapy for primary cutaneous anaplastic large-cell lymphoma while on low-dose methotrexate.
    Cutis 2016 Oct;98(4):253-256
    Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.
    Primary cutaneous anaplastic large-cell lymphoma (pcALCL) is part of a spectrum of CD30+ primary cutaneous lymphoproliferative disorders (pcLPDs) that also includes lymphomatoid papulosis (LyP). Localized radiotherapy at doses of 34 to 44 Gy is first-line treatment of pcALCL, but the use of low-dose radiotherapy for pcALCL has not been reported. We present the case of a patient with a history of pcALCL/LyP who was treated with low-dose radiotherapy while on oral low-dose methotrexate (MTX) once weekly. Read More

    Histopathological aspects and differential diagnosis of CD8 positive lymphomatoid papulosis.
    J Cutan Pathol 2016 Nov 30;43(11):963-973. Epub 2016 Aug 30.
    1st Department of Pathology and Experimental Cancer Research Institute, Semmelweis University, Budapest, Hungary.
    Lymphomatoid papulosis (LyP) belongs to CD30+ lymphoproliferative disorders with indolent clinical course. Classic histological subtypes, A, B and C are characterized by the CD4+ phenotype, while CD8+ variants, most commonly classified as type D, were reported in recent years. We present 14 cases of CD8+ LyP. Read More

    CD30+ lymphoproliferative disorder with spindle-cell morphology.
    J Cutan Pathol 2016 Nov 26;43(11):1041-1044. Epub 2016 Aug 26.
    Department of Pathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA.
    Lymphomatoid papulosis (LyP) is classified as a CD30+ primary cutaneous lymphoproliferative disease. The phenotypic variability along the spectrum of CD30+ lymphoproliferative diseases is highlighted by the distinct histologic subtypes of LyP types A, B, C, and the more recently described types D, E, and F. We report the case of an elderly woman with a clinical presentation and histopathologic findings consistent with LyP, whose atypical CD30+ infiltrate uniquely demonstrated a spindle-cell morphology. Read More

    CD30 Positive Lymphomatoid Angiocentric Drug Reactions: Characterization of a Series of 20 Cases.
    Am J Dermatopathol 2017 Jul;39(7):508-517
    *Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY; †Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO; and ‡Department of Dermatology, University of California at Irvine, Orange, CA.
    Introduction: Lymphomatoid drug reactions are atypical T cell cutaneous lymphocytic infiltrates induced by pharmacological therapy. Due to phenotypic abnormalities, clonality, and their close clinical and morphologic resemblance to T cell lymphomas, these eruptions have been categorized as drug-associated reversible granulomatous T cell dyscrasias.

    Design: A total of 20 cases were encountered in which a diagnosis of CD30 lymphomatoid drug reaction was rendered. Read More

    Dermoscopy in General Dermatology: A Practical Overview.
    Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.
    Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

    Primary cutaneous CD30(+) lymphoproliferative disorders.
    J Dtsch Dermatol Ges 2016 Aug;14(8):767-82
    Department of Dermatology, The University of Texas, MD Anderson Cancer Center, Houston Texas, U.S.A.
    Primary cutaneous CD30(+) lymphoproliferative disorders are the second most common group of cutaneous T-cell lymphomas (CTCL) and include lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Both disease entities share overlapping clinical, histopathological, and molecular features, thus representing a spectrum of cutaneous CD30(+) lymphoproliferative disorders. LyP may be distinguished from cALCL by clinicopathological correlation. Read More

    Synchronous Occurrence of Primary Cutaneous Anaplastic Large Cell Lymphoma and Squamous Cell Carcinoma.
    Ann Dermatol 2016 Aug 26;28(4):491-4. Epub 2016 Jul 26.
    Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    CD30+ lymphoproliferative disorders (LPD) represent a spectrum of T-cell lymphoma including lymphomatoid papulosis and anaplastic large cell lymphoma (ALCL). Epidermis overlying cutaneous CD30+ LPD often shows epidermal hyperplasia, hyperkeratosis, crusting, and ulceration and it is difficult to distinguish from carcinoma such as keratoacanthoma (KA) or squamous cell carcinoma (SCC). Several cases of pseudocarcinomatous hyperplasia mimicking KA or SCC in CD30+ LPD have been reported. Read More

    Methotrexate-associated primary cutaneous CD30-positive cutaneous T-cell lymphoproliferative disorder: a case illustration and a brief review.
    Am J Blood Res 2016 18;6(1):1-5. Epub 2016 May 18.
    Division of Hematology and Medical Oncology, James Graham Brown Cancer Center, University of Louisville Health Sciences Center Louisville, Kentucky, USA.
    Methotrexate (MTX) is a commonly used anti-metabolite agent. Increased risk of lymphoproliferative disorders (LPD) in patients with rheumatoid arthritis (RA) has been documented with the prolonged use of immunosuppressive medications such as MTX. This is thought to be the result of immune dysregulation and/or chronic immune stimulation. Read More

    Regional lymphomatoid papulosis of the breast restricted to an area of prior radiotherapy.
    Cutis 2016 May;97(5):E15-9
    Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain.
    We report the case of a 59-year-old woman with type A regional lymphomatoid papulosis (LyP) that was localized to the left breast, a cutaneous area that had received radiotherapy for treatment of a carcinoma of the breast 5 years prior. This report is a rare example of regional LyP with all lesions located in an area of prior radiotherapy. Read More

    Primary Cutaneous Lymphomas in Children and Adolescents.
    Pediatr Blood Cancer 2016 Nov 27;63(11):1886-94. Epub 2016 May 27.
    Division of Hematology/Oncology, Department of Pediatrics, Hospital for Sick Children, Ontario, Toronto, Canada.
    Primary cutaneous lymphomas are rare in children and mostly represented by mycosis fungoides and CD30(+) lymphoproliferative disorders. Most pediatric cutaneous lymphomas have similar clinical/pathological features as their adult counterparts, particularly the T-cell subtypes. With regard to outcome, adult cutaneous mature T-cell lymphomas have a tendency to progression, while this appears to be relatively infrequent in children. Read More

    A child with mastocytosis and lymphomatoid papulosis.
    Clin Case Rep 2016 May 14;4(5):517-9. Epub 2016 Apr 14.
    Department of Dermatology and Allergy Centre Odense University Hospital Sdr. Boulevard 29, 5000 Odense C Denmark.
    A change in clinical behavior of a disease should prompt search for differential diagnoses. Here, the appearance of ulcerated skin nodules in a preexisting cutaneous mastocytosis revealed a concurrent lymphomatoid papulosis - a CD30+ lymphoproliferative skin disease with histological features of a malignant lymphoma, but with a benign self-healing course. Read More

    Lymphomatoid Papulosis in Children and Adolescents: A Systematic Review.
    Am J Clin Dermatol 2016 Aug;17(4):319-27
    Department of Dermatology, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030-4095, USA.
    Background: Lymphomatoid papulosis (LyP) is a lymphoproliferative disorder that is rare among adults and even rarer among children. In adults, LyP is associated with an increased risk of secondary lymphomas.

    Objective: The aim of this systematic review was to describe the clinical and histopathological features of LyP in children, to assess the risk of associated lymphomas, and to compare the disease to the adult form. Read More

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