939 results match your criteria Lymphomatoid Papulosis


Lymphomatoid papulosis successfully managed with excimer laser maintenance therapy.

JAAD Case Rep 2020 Jun 18;6(6):495-497. Epub 2020 Apr 18.

Department of Dermatology, University of California, San Francisco, California.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256238PMC

Lichen planopilaris in a patient treated with bexarotene for lymphomatoid papulosis.

Cutis 2020 Apr;105(4):E19-E21

Department of Medicine-Dermatology, David Geffen School of Medicine, University of California Los Angeles, USA.

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Primary Cutaneous CD30+ Lymphoproliferative Disorders: a Comprehensive Review.

Curr Hematol Malig Rep 2020 May 20. Epub 2020 May 20.

City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA.

Purpose Of Review: Primary cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ LPDs) are the second most common cutaneous lymphomas after mycosis fungoides and Sezary syndrome. They include primary cutaneous anaplastic large cell lymphoma (pcALCL), lymphomatoid papulosis (LyP), and borderline lesions. The purpose of this literature review is to consolidate the available evidence on the primary cutaneous CD30+ LPD in order to define the tools for correct diagnosis and appropriate treatment. Read More

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http://dx.doi.org/10.1007/s11899-020-00583-4DOI Listing

Topical methotrexate in dermatology: a review of the literature.

J Dermatolog Treat 2020 May 25:1-6. Epub 2020 May 25.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Systemic methotrexate (MTX) is a useful treatment for many dermatologic conditions, however, the risk of adverse events prevents its use in patients with minimal or localized disease. Topical application of MTX may be an option to avoid the systemic adverse effects of oral MTX.: To assess what is known about the efficacy and safety of topical methotrexate. Read More

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http://dx.doi.org/10.1080/09546634.2020.1770170DOI Listing

Clinical and dermoscopic features of pediatric lymphomatoid papulosis: an Italian multicenter study.

Int J Dermatol 2020 Apr 25. Epub 2020 Apr 25.

Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1111/ijd.14885DOI Listing

Primary cutaneous peripheral T-cell lymphoma, not otherwise specified, associated with lymphomatoid papulosis after a 9-year follow up: A case report.

J Dermatol 2020 Jun 22;47(6):641-645. Epub 2020 Apr 22.

Departments of, Department of, Dermatology, Wakayama Medical University, Wakayama, Japan.

Lymphomatoid papulosis (LyP) is a self-limiting cutaneous T-cell lymphoproliferative disorder that may progress into malignant lymphoma. Most of the previously reported associated lymphomas are primary cutaneous anaplastic large-cell lymphoma and mycosis fungoides with a low mortality rate. We report a case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified (pcPTCL-NOS), associated with LyP after long-term follow up. Read More

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http://dx.doi.org/10.1111/1346-8138.15351DOI Listing

Lymphomatoid papulosis in children and adolescents: A clinical and histopathologic retrospective cohort.

Ann Diagn Pathol 2020 Mar 3;46:151486. Epub 2020 Mar 3.

Weill Cornell Medical College, Department of Pathology & Laboratory Medicine, New York, NY, United States of America.

Background, Aims And Objectives: Lymphomatoid papulosis (LyP) is a CD30+ lymphoproliferative disorder that is rare and not well described within the pediatric subpopulation. We sought to review the literature and characterize clinical and pathologic features among pediatric and adolescent patients diagnosed with LyP at a tertiary care center.

Materials And Methods: A retrospective cohort of 27 pediatric and adolescent patients (defined as <20 years old) diagnosed with LyP at the Weill Cornell Medicine Dermatopathology division from 2006 to 2016 was identified. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151486DOI Listing

Recurrent Oncogenic JAK and STAT Alterations in Cutaneous CD30-Positive Lymphoproliferative Disorders.

J Invest Dermatol 2020 Mar 5. Epub 2020 Mar 5.

Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Wuerzburg, Germany; Department of Dermatology, Venereology and Allergology and Skin Cancer Center, University Hospital Wuerzburg, Wuerzburg, Germany.

The group of cutaneous CD30-positive lymphoproliferative disorders (LPD) comprises two different entities, namely lymphomatoid papulosis (LyP) and cutaneous anaplastic large T-cell lymphoma (cALCL). LyP constitutes a benign lymphoproliferation with spontaneously regressing papules, whereas cALCL presents with solitary or multiple skin tumors with a low propensity to disseminate. To elucidate the hitherto largely unknown molecular pathogenesis of these entities, we performed comprehensive next-generation sequencing in a well-characterized cohort of 12 patients. Read More

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http://dx.doi.org/10.1016/j.jid.2020.02.019DOI Listing

Lymphomatoid papulosis.

J Dtsch Dermatol Ges 2020 Mar 26;18(3):199-205. Epub 2020 Feb 26.

Skin Cancer Center, Department of Dermatology, Allergology and Phlebology, Bremerhaven Reinkenheide Medical Center, Bremerhaven, Germany.

Lymphomatoid papulosis (LyP) is characterized by a varied clinical presentation that includes erythema, papules, pustules, vesicles, plaques, nodules and ulcerations. While its biological course is typically marked by spontaneous regression, the histopathological findings of LyP are consistent with cutaneous T-cell lymphoma. Provided patients do no develop a secondary lymphoma, they exhibit unusually high 10-year survival rates (> 90 %), which is a typical feature of LyP. Read More

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http://dx.doi.org/10.1111/ddg.14041DOI Listing

Nitrogen mustard gel-induced inflammation triggers lymphomatoid papulosis in patients with mycosis fungoides.

J Dermatol 2020 May 26;47(5):546-550. Epub 2020 Feb 26.

Departments of, Dermatology, Columbia University, New York, New York, USA.

Lymphomatoid papulosis (LyP) is a paraneoplastic primary cutaneous CD30 lymphoproliferative disorder (LPD) that has been associated with malignant lymphomas, most commonly mycosis fungoides (MF). We observed 10 patients with MF who developed severe inflammation after using nitrogen-mustard (NM) gel from 1 to 8 months and who developed LyP. We hypothesized that NM gel produced local inflammation, which induced CD30 expression in malignant T cells in situ leading to the appearance of LyP papules. Read More

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http://dx.doi.org/10.1111/1346-8138.15276DOI Listing

Evidence linking atopy and staphylococcal superantigens to the pathogenesis of lymphomatoid papulosis, a recurrent CD30+ cutaneous lymphoproliferative disorder.

PLoS One 2020 12;15(2):e0228751. Epub 2020 Feb 12.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

Background: Primary cutaneous CD30+ lymphoproliferative disorders (CD30CLPD) are the second most common type of cutaneous T cell lymphoma (CTCL) and include lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (pcALCL). Case reports and small patient series suggest an association of CD30CLPD with atopic disorders. However, the prevalence of atopy in patients with CD30CLPD in retrospective studies depends on patients' recall which is not always reliable. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228751PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015403PMC

Mycosis Fungoides, Lymphomatoid Papulosis and Hodgkin's Lymphoma in the Same Patient: Apropos of a Possible Monoclonal Origin.

Indian J Dermatol 2020 Jan-Feb;65(1):57-60

Department of Pathology, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile.

A 59-year-old man with Hodgkin's lymphoma was referred by a hematologist for consultation for cutaneous issues. Physical examination revealed generalized scaling and erythematous scaly patches located in the groin, abdomen, and arms. The biopsy was compatible with mycosis fungoides (MF). Read More

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http://dx.doi.org/10.4103/ijd.IJD_16_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986121PMC
February 2020

Clinical Characteristics and Disease Course in Black Patients With Lymphomatoid Papulosis: A Case Series

J Drugs Dermatol 2020 Jan;19(1):89-91

INTRODUCTION: Lymphomatoid papulosis (LyP) is a CD30+ T-cell lymphoproliferative disorder (LPD) presenting as a recurrent eruption of papules and nodules which resolve spontaneously. CD30+ LPD prevalence in African American (AA)/Black patients is lower compared to White patients. CD30+ LPD has been recently reported to have worse outcomes in AA patients compared to White patients. Read More

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http://dx.doi.org/10.36849/JDD.2020.4602DOI Listing
January 2020

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in the Elderly and the Importance of Sport Activity Training.

Int J Environ Res Public Health 2020 01 29;17(3). Epub 2020 Jan 29.

Department of Mental Health and Preventive, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.

Primary cutaneous anaplastic large cell lymphoma (pcALCL) is part of a spectrum of cutaneous CD30+ lymphoproliferative disease that also includes lymphomatoid papulosis. It often occurs in elderly patients, presenting at a median age of 60 years, although it may occur at any age. It is a CD30+ T-cell neoplasm composed of large cells with anaplastic, pleomorphic, or immunoblastic morphology, with exclusively cutaneous onset and localization. Read More

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http://dx.doi.org/10.3390/ijerph17030839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037068PMC
January 2020

Frequency, risk factors and prognosis of systemic haematologic malignancies, cutaneous and other neoplasms in lymphomatoid papulosis: where are we now?

Authors:
F Rongioletti

J Eur Acad Dermatol Venereol 2020 02;34(2):216-217

Department of Medical Sciences and Public Health, Unit of Dermatology, University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.1111/jdv.16157DOI Listing
February 2020

Lymphomatoid Papulosis.

JAMA Dermatol 2020 Jan 29. Epub 2020 Jan 29.

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri.

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http://dx.doi.org/10.1001/jamadermatol.2019.4513DOI Listing
January 2020

Lymphomatoid papulosis.

Minerva Med 2020 Apr 20;111(2):166-172. Epub 2020 Jan 20.

Unit of Dermatology, University of Campania, Naples, Italy.

Lymphomatoid papulosis (LyP) is a non-aggressive skin disorder characterized by papulonodular injuries, sometimes necrotic, often scattered, relapsing, which frequently regress spontaneously. LyP represents about 12% of cutaneous lymphomas. The etiology of LyP is unknown. Read More

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http://dx.doi.org/10.23736/S0026-4806.19.06395-XDOI Listing

Pediatric cellular neurothekeoma: Seven cases and systematic review of the literature.

Pediatr Dermatol 2020 Mar 12;37(2):320-325. Epub 2020 Jan 12.

Dermatology Department, Phoenix Children's Hospital, Phoenix, Arizona.

Background/objectives: Neurothekeoma is a rare, benign, cutaneous neoplasm consisting of Schwann cells and perineural cells in myxoid stroma. Cellular neurothekeoma (CNT) was previously thought to represent a morphologic variant of neurothekeoma, but recent studies have shown that CNTs are unrelated to neurothekeomas and are more likely of histiocytic lineage.

Methods: Herein, we describe seven cases of CNT in pediatric patients. Read More

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http://dx.doi.org/10.1111/pde.14043DOI Listing
March 2020
1.520 Impact Factor

Comorbidities in Mycosis Fungoides and Racial Differences in Co-Existent Lymphomatoid Papulosis: A Cross-Sectional Study of 580 Patients in an Urban Tertiary Care Center.

Medicines (Basel) 2019 Dec 26;7(1). Epub 2019 Dec 26.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Mycosis fungoides (MF) is a cutaneous T-cell lymphoma. Previous reports have suggested MF is associated with inflammatory conditions such as psoriasis, increased cardiovascular risk factors as well as secondary neoplasms. A cross-sectional study of MF patients seen from 2013 to 2019 was performed. Read More

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http://dx.doi.org/10.3390/medicines7010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168128PMC
December 2019

Frequency and prognosis of associated malignancies in 504 patients with lymphomatoid papulosis.

J Eur Acad Dermatol Venereol 2020 Feb 5;34(2):260-266. Epub 2019 Dec 5.

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

Background: Lymphomatoid papulosis (LyP) can be associated with other haematological malignancies (HM), but reported percentages vary from 20% to over 50%.

Objective: To evaluate the frequency and prognostic significance of associated HM and non-HM in LyP patients.

Methods: In this multicentre cohort study, the complete Dutch LyP population was included from the Dutch Cutaneous Lymphoma Registry between 1985 and 2018. Read More

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http://dx.doi.org/10.1111/jdv.16065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028293PMC
February 2020
8 Reads

Traumatic Ulcerative Granuloma with Stromal Eosinophilia: CD30 analysis and clonality for T cell receptor gene re-arrangement.

Acta Histochem 2019 Nov 29;121(8):151450. Epub 2019 Oct 29.

Institute of Pathology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; Department of Oral Pathology and Oral Medicine, Goldschleger School of Dental Medicine, Tel-Aviv University, Tel Aviv, Israel; Sourasky Faculty of Medicine, Tel-Aviv University, Israel. Electronic address:

Introduction: Traumatic Ulcerative Granuloma with Stromal Eosinophilia (TUGSE) is a rare oral ulcerated lesion of uncertain etiology, showing eosinophil-rich granulation tissue, with occasional large atypical CD30 positive mononuclear cells. It had been suggested that it may represent an oral counterpart of cutaneous lymphomatoid papulosis, with a potential to evolve into CD30 + T cell lymphoma OBJECTIVES: To compare TUGSE and non-specific oral ulcers (NSU) clinically, histopathologically and by clonality analysis for T-cell receptor re-arrangement, aiming to determine whether TGUSE with atypical cells is a lymphomatous premalignant condition, and whether therapeutic approach should be radical or conservative.

Materials And Methods: Retrospective archival analysis included 17 TUGSE and 8 NSU cases. Read More

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http://dx.doi.org/10.1016/j.acthis.2019.151450DOI Listing
November 2019
1 Read

Diagnosis of T-cell lymphoid proliferations of the skin: putting all the pieces together.

Mod Pathol 2020 01 29;33(Suppl 1):83-95. Epub 2019 Oct 29.

Departments of Pathology and Dermatology, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 85, Houston, TX, 77030, USA.

The spectrum of T-cell lymphoid proliferations of the skin varies from indolent to highly aggressive diseases and therefore an accurate pathological diagnosis is paramount. Integration of clinical, histopathological, immunohistochemical, and molecular findings is of crucial importance in the evaluation of these processes. In this article, we discuss selected situations where difficulty may arise for the pathologist evaluating this type of skin biopsies, such as: the diagnosis of early (patch stage) mycosis fungoides, the distinction of mycosis fungoides with large cell transformation from primary cutaneous anaplastic large cell lymphoma, the recognition of new histopathological patterns of lymphomatoid papulosis and the entities they mimic, the evaluation of primary cutaneous anaplastic large cell lymphoma with expression of markers suggestive of systemic origin (such as ALK), the awareness of the wide range of clinical and pathological presentations of hydroa vacciniforme-like EBV-positive T-cell lymphoproliferative disorders, the evaluation of cases of primary cutaneous γδ T-cell lymphoma showing predominantly epidermotropic pattern of growth, and the correct interpretation of findings seen in indolent proliferations such as primary cutaneous acral CD8-positive T-cell lymphoma and primary cutaneous small/medium size CD4 + T-cell lymphoproliferative disorder. Read More

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http://dx.doi.org/10.1038/s41379-019-0397-3DOI Listing
January 2020
4 Reads

Does Breast Implant-Associated ALCL Begin as a Lymphoproliferative Disorder?

Plast Reconstr Surg 2020 01;145(1):30e-38e

Providence, R.I.; Dallas, Texas; New York, N.Y.; and Rome, Italy From the Department of Dermatology, Boston University School of Medicine and Roger Williams Medical Center; the Department of Plastic Surgery, University of Texas Southwestern Medical School; the Department of Pathology and Laboratory Medicine, Weill Cornell College of Medicine; and the Department of Clinical and Molecular Medicine, Sapienza University, Pathology Unit, Sant'Andrea Hospital.

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has been included as a provisional entity in the revised version of the World Health Organization Classification of Tumors of Haematopoietic and Lymphoid Tissue. To increase opportunities to intervene with early diagnosis, treatment, and possible prevention, it is important to consider that BIA-ALCL may evolve from a preexisting lymphoproliferative disorder characterized by (1) an indolent localized (in situ) disease in approximately 80 percent of reported cases; (2) a requirement for external cytokine stimulation for cell survival; (3) CD30 cells in some clinically benign seromas/capsules; (4) undetected T-cell clonality in some cases; (5) JAK/STAT mutations in only a minority of cases; and (6) cure by capsulectomy and implant removal in most cases. BIA-ALCL resembles CD30 cutaneous lymphoproliferative disorder: ALK, CD30 anaplastic cells with an aberrant T-cell phenotype; overexpression of oncogenes (JUNB, SATB1, pSTAT3, SOCS3) in lymphomatoid papulosis; frequent apoptosis; complete spontaneous regression in lymphomatoid papulosis; and partial spontaneous regression in cutaneous ALCL. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006390DOI Listing
January 2020
3 Reads

Lymphomatoid Papulosis Type B in a Patient with Crohn's Disease Treated with TNF-Alpha Inhibitors Infliximab and Adalimumab.

Acta Dermatovenerol Croat 2019 Sep;27(3):202-204

Márta Medvecz, MD, PhD, Department of Dermatology, Venerology and Dermatooncology, Semmelweis University, Mária utca 41, 1085 Budapest, Hungary;

Dear Editor, Lymphomatoid papulosis (LP) is a chronic, recurrent, usually self-limited papulonecrotic or papulonodular skin disease, which belongs to the group of primary cutaneous CD30+ lymphoproliferative disorders (1). Three main histological subtypes of LP have been recognized: type A (histiocytic), type B (mycosis fungoides-like), and type C (anaplastic large cell lymphoma-like). Recently, new histologic LP variants classified as type D (CD8-positive, cytotoxic form) and type E (angioinvasive form) have also been described. Read More

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September 2019
7 Reads

Angiodestructive lymphomatoid papulosis lasting more than 45 years.

JAAD Case Rep 2019 Sep 29;5(9):767-769. Epub 2019 Aug 29.

Department of Dermatology, Stanford Cancer Institute, Stanford, California.

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http://dx.doi.org/10.1016/j.jdcr.2019.06.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728836PMC
September 2019
2 Reads

Lymphomatoid papulosis: an update and review.

J Eur Acad Dermatol Venereol 2020 Jan 14;34(1):59-73. Epub 2019 Oct 14.

Department of Medicine, University of Toronto, Toronto, ON, Canada.

Lymphomatoid papulosis (LyP) is a benign chronic often relapsing skin condition that belongs to the CD30-positive cutaneous lymphoproliferative disorders. LyP typically presents as crops of lesions with a tendency to self-resolve, and morphology can range from solitary to agminated or diffuse papules and plaques to nodules or tumours. The clinical-histological spectrum can range from borderline cases to overlap with primary cutaneous anaplastic cell lymphoma (pcALCL). Read More

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http://dx.doi.org/10.1111/jdv.15931DOI Listing
January 2020
4 Reads

Lymphomatoid Papulosis and Other Lymphoma-Like Diseases.

Dermatol Clin 2019 Oct 6;37(4):471-482. Epub 2019 Aug 6.

Department of Dermatology and Cutaneous Surgery, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA. Electronic address:

Pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica are the 2 main subtypes of pityriasis lichenoides. They represent the acute and chronic forms of the disease; both may have clonal T cells. Several treatment modalities are used, but it has been difficult to determine efficacy because of the possibility of spontaneous remission. Read More

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http://dx.doi.org/10.1016/j.det.2019.05.005DOI Listing
October 2019
4 Reads

Trichoscopic features of lymphomatoid papulosis.

J Eur Acad Dermatol Venereol 2020 Jan 4;34(1):e47-e49. Epub 2019 Sep 4.

Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, Gdańsk, Poland.

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http://dx.doi.org/10.1111/jdv.15896DOI Listing
January 2020
2 Reads

Lymphomatoid Papulosis Type A: A Case Report of the "Wait-and-See Strategy" in a 27-Year-Old Male Patient with Extensive Disease.

Case Rep Dermatol Med 2019 16;2019:1765210. Epub 2019 Jul 16.

Department of Dermatology, University General Hospital of Heraklion, 71500 Heraklion, Greece.

This is the case of a 27-year-old male patient with a newly diagnosed extensive lymphomatoid papulosis type A involving cosmetically sensitive areas (e.g. face), who refused to be treated with a low dose of methotrexate, as recommended by the published literature. Read More

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https://www.hindawi.com/journals/cridm/2019/1765210/
Publisher Site
http://dx.doi.org/10.1155/2019/1765210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662440PMC
July 2019
4 Reads

Recent Advances in Cutaneous T-cell Lymphoma: Diagnostic and Prognostic Considerations.

Surg Pathol Clin 2019 Sep;12(3):783-803

Department of Pathology, University of Virginia, PO Box 800214, 1215 Lee Street, Hospital Expansion Building Room 3018, Charlottesville, VA 22908, USA. Electronic address:

This review describes the latest advances in the diagnosis of cutaneous T-cell lymphoma focusing on the most clinically useful features introduced since the publication of the World Health Organization revision in 2017. Clinical entities described include mycosis fungoides, Sézary syndrome, lymphomatoid papulosis, primary cutaneous anaplastic large cell lymphoma, primary cutaneous gamma delta T-cell lymphoma, primary cutaneous acral CD8 T-cell lymphoma, primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder, and hydroa-vacciniforme-like lymphoproliferative disorder. Distinguishing histologic clues to diagnosis are discussed, and important molecular advances are described. Read More

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http://dx.doi.org/10.1016/j.path.2019.03.006DOI Listing
September 2019
4 Reads

Type D lymphomatoid papulosis associated with chemotherapy/chemoradiotherapy-induced severe chronic lymphocytopenia.

J Dermatol 2019 Nov 25;46(11):e412-e414. Epub 2019 Jul 25.

Departments of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

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http://dx.doi.org/10.1111/1346-8138.15019DOI Listing
November 2019
4 Reads

Treatment of primary cutaneous anaplastic large cell lymphoma.

Arch Craniofac Surg 2019 Jun 20;20(3):207-211. Epub 2019 Jun 20.

Department of Pathology, Dong-Kang General Hospital, Ulsan, Korea.

Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is a rare subtype of primary cutaneous lymphoma with a favorable prognosis. Primary cutaneous CD30+ lymphoproliferative disorders, which include C-ALCL and lymphomatoid papulosis, are the second most common group of cutaneous T-cell lymphomas. C-ALCL is comprised of large cells with anaplastic, pleomorphic, or immunoblastic cytomorphology, and indeed, more than 75% of the tumor cells express the CD30 antigen. Read More

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http://dx.doi.org/10.7181/acfs.2018.02201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615420PMC
June 2019
6 Reads

18F-FDG PET/CT in Lymphomatoid Papulosis Mimicking Primary Cutaneous Anaplastic Large Cell Lymphoma.

Clin Nucl Med 2019 Nov;44(11):e609-e611

Pathology.

Lymphomatoid papulosis is a benign self-healing condition, presenting as papulonodular skin eruptions and mimicking malignant cutaneous lymphomas histopathologically. F-FDG PET/CT findings in this benign condition have not been described in detail in the literature. We present a case of lymphomatoid papulosis mimicking primary cutaneous anaplastic large cell lymphoma histopathologically and demonstrating intensely FDG-avid cutaneous lesions on F-FDG PET/CT, which disappear spontaneously in the follow-up scan. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002674DOI Listing
November 2019
7 Reads

Pretibial Pruritic Papular Dermatitis: A Comprehensive Clinical and Pathologic Review of Cases at a Single Institution.

Am J Dermatopathol 2020 Jan;42(1):16-19

Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT.

Background: Studies characterizing clinical and pathologic details of pretibial pruritic papular dermatitis (PPPD) are scarce. Several cases of PPPD at our institution have displayed lymphocyte atypia and CD30 positivity, resembling lymphomatoid papulosis (LyP). We explore the clinical and histological spectrum of PPPD, with emphasis on lymphocyte atypia. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001460DOI Listing
January 2020
21 Reads

Cutaneous lymphomas-An update 2019.

Hematol Oncol 2019 Jun;37 Suppl 1:43-47

Department of Dermatology, Venereology and Allergology, University Medical Center, Göttingen, Germany.

Primary cutaneous lymphomas (CL) are the second most common form of extranodal lymphomas. Cutaneous T-cell lymphomas represent the majority. They are classified according to the WHO classification 2017 and the updated WHO-EORTC 2018 published in the fourth edition of the WHO classification for Skin Tumors monograph. Read More

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http://dx.doi.org/10.1002/hon.2584DOI Listing
June 2019
14 Reads

How I treat primary cutaneous CD30 lymphoproliferative disorders.

Blood 2019 08 4;134(6):515-524. Epub 2019 Jun 4.

Division of Hematology, Department of Medicine, University of Washington, Seattle, WA.

The primary cutaneous CD30 lymphoproliferative disorders are a family of extranodal lymphoid neoplasms that arise from mature postthymic T cells and localize to the skin. Current classification systems recognize lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma, and borderline cases. In the majority of patients, the prognosis of primary cutaneous CD30 lymphoproliferative disorders is excellent; however, relapses are common, and complete cures are rare. Read More

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http://dx.doi.org/10.1182/blood.2019000785DOI Listing
August 2019
8 Reads

Expression of CCR3 and CCR4 Suggests a Poor Prognosis in Mycosis Fungoides and Sézary Syndrome.

Acta Derm Venereol 2019 Jul;99(9):809-812

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Tumor cells in cutaneous T-cell lymphoma express limited numbers of chemokine receptors. We investigated the expression patterns of CXCR3, CCR3, CCR4 and CCR10 in mycosis fungoides, Sézary syndrome, lym-phomatoid papulosis and anaplastic large cell lymphoma in 121 skin biopsy samples. CXCR3 was expressed in 86% of mycosis fungoides cases but in no anaplastic large cell lymphoma cases. Read More

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http://dx.doi.org/10.2340/00015555-3207DOI Listing
July 2019
13 Reads

Lymphomatoid papulosis type E with a CD56+ immunophenotype presenting with purpura-like lesions.

J Cutan Pathol 2019 Jul 3;46(7):542-545. Epub 2019 May 3.

Department of Dermatology, Chinese PLA General Hospital and Medical School, Beijing, China.

Lymphomatoid papulosis (LyP) type E is a recently described variant characterized by the occurrence of large necrotic eschar-like lesions displaying microscopically angioinvasive and angiodestructive infiltrates of CD30+ lymphocytes, frequently coexpressing CD8. Rare cases of LyP type E with a CD56+ immunophenotype have been described. Herein, we describe a 36-year-old woman with LyP type E, characterized by purpura-like lesions on her left ankle. Read More

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http://dx.doi.org/10.1111/cup.13472DOI Listing
July 2019
9 Reads

Mycosis Fungoides Associated With Lesions in the Spectrum of Primary Cutaneous CD30+ Lymphoproliferative Disorders: The Same Process or 3 Coexisting Lymphomas?

Am J Dermatopathol 2019 Nov;41(11):846-850

Departments of Dermatology.

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma, primary cutaneous CD30 lymphoproliferative disorders (pc CD30 LPD) being the second most prevalent. There is evidence that MF and pc CD30 LPD may coexist and share T-cell clonality, suggesting a common origin. These findings were supported by a T-cell receptor clonality assessment by the polymerase chain reaction coupled with capillary electrophoresis, although results produced by this method may be ambiguous. Read More

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http://Insights.ovid.com/crossref?an=00000372-900000000-9816
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http://dx.doi.org/10.1097/DAD.0000000000001423DOI Listing
November 2019
24 Reads

[Multisystem histiocytosis of Langerhans cells associated with Lymphomatoid papulosis: An accidental finding? Case report and literature review].

Rev Esp Patol 2019 Apr - Jun;52(2):130-135. Epub 2018 Jul 4.

Servicio de Anatomía Patológica, Hospital Universitario Joan XXIII, Tarragona, España; Universidad Rovira i Virgili, Tarragona, España; Institut d'Investigació Sanitària Pere Virgili, Tarragona, España.

Langerhans cell histiocytosis (LCH) is a disease characterized by proliferation of CD1a+dendritic cells with local or diffuse organ compromise. The identification of recurrent gene mutations has confirmed the hypothesis of LCH as a true neoplasm. Lymphomatoid papulosis (LyP) belongs to the spectrum of CD30+primary cutaneous lymphomas. Read More

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http://dx.doi.org/10.1016/j.patol.2018.04.004DOI Listing
May 2020
8 Reads

γδ lymphomatoid papulosis type D: A histologic mimic of primary cutaneous γδ T-cell lymphoma.

JAAD Case Rep 2019 Mar 1;5(3):264-266. Epub 2019 Mar 1.

Department of Pathology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1016/j.jdcr.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403113PMC
March 2019
9 Reads

A case of febrile ulceronecrotic Mucha-Habermann disease with comorbidities.

Indian J Dermatol Venereol Leprol 2019 Nov-Dec;85(6):660-663

Department of Dermatology, K. E. M. Hospital, Pune, Maharashtra, India.

Febrile ulceronecrotic Mucha-Habermann disease is a very rare and severe variant of pityriasis lichenoides et varioliformis acuta. Adult cases are difficult to diagnose as in the early course they can mimic erythema multiforme or lymphomatoid papulosis. We report a case of a 38-year-old woman who presented with 90% body surface area involvement, fever, diarrhea, malaise and associated comorbidities. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_552_17DOI Listing
February 2020
17 Reads

The spectrum of CD30+ T cell lymphoproliferative disorders in the skin.

Chin Clin Oncol 2019 Feb 9;8(1). Epub 2019 Jan 9.

Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.

Primary cutaneous CD30+ T cell lymphoproliferative disorders (pcCD30+ T cell LPDs) are a spectrum of pre-malignant to frankly neoplastic lymphoproliferations that comprise lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma (pcALCL), and borderline lesions. Although the atypical T cells that are the hallmark of these disorders share the expression of CD30, as the identifying marker, the clinical presentation, histological features and clinical course are vastly different. Furthermore, histopathologic features of pcCD30+ T cell LPDs may overlap with other cutaneous and systemic lymphomas. Read More

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http://dx.doi.org/10.21037/cco.2018.12.03DOI Listing
February 2019
15 Reads

CD30-Positive Angioinvasive Lymphomatoid Papulosis (Type E) Developing from Parapsoriasis en Plaque.

Case Rep Oncol 2018 Sep-Dec;11(3):850-854. Epub 2018 Dec 13.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Angioinvasive lymphomatoid papulosis (LyP) type E is a rare variant characterized by angiocentric and angiodestructive features with CD30+ CD8+ lymphocyte infiltration. In rare cases, LyP type E is concomitant with mycosis fungoides, but there is no English report that describe LyP type E developing from parapsoriasis en plaque. In this report, we described a case of angioinvasive LyP (type E) developing from parapsoriasis en plaque, in which we employed immunohistochemical staining for the investigation of its pathomechanisms. Read More

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http://dx.doi.org/10.1159/000495689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341360PMC
December 2018
12 Reads

ALK-negative anaplastic large cell lymphoma arising in the thrombus of an aortic prosthesis preceeded by clonally related lymphomatoid papulosis.

Virchows Arch 2019 Jun 26;474(6):763-767. Epub 2019 Jan 26.

Institute of Pathology and Medical Genetics, University Hospital Basel, Schönbeinstrasse 40, 4031, Basel, Switzerland.

We report on a 73-year-old male patient with recurrent thrombosis of his infrarenal aortic prosthesis. Histologically, the thrombus contained cells of an ALK-negative anaplastic large cell T cell lymphoma (ALCL). Imaging studies were negative for other lymphoma manifestations; however, 3 months before, the patient had developed skin lesions consistent with lymphomatoid papulosis type A (LypA) which were clonally related to the ALCL. Read More

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http://dx.doi.org/10.1007/s00428-019-02531-xDOI Listing
June 2019
14 Reads

Lymphomatoid papulosis.

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, New York.

Lymphomatoid papulosis is often regarded as a low-grade variant of cutaneous T cell lymphoma (CTCL). Given the excellent long-term prognosis, recent consensus guidelines indicate that patients can be monitored off therapy. We report a case of a 67-year-old man who presented with lymphomatoid papulosis, with necrotic papules that have been intermittently present for over forty years. Read More

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December 2018
8 Reads

Acitretin combined with NB-UVB in the treatment of cutaneous CD30-positive anaplastic large cell lymphoma.

Dermatol Ther 2019 03 27;32(2):e12834. Epub 2019 Feb 27.

Department of Dermatology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Cutaneous CD30 lymphoproliferative disorders represent a spectrum of skin lymphatic reticular proliferative diseases, including lymphomatoid papulosis (LYP), primary cutaneous anaplastic large cell lymphoma (PC-ALCL), and borderline lesions between them. Although they all express CD30 as a phenotypic marker and share overlapping immunophenotypic features, they differ in clinical manifestations, pathological features, treatment, and prognosis. LYP is a kind of benign disease characterized by recurrent papules and nodules, and may spontaneously regress. Read More

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http://dx.doi.org/10.1111/dth.12834DOI Listing
March 2019
13 Reads

Type A lymphomatoid papulosis presenting as an eyelid ulcer in a young man.

Orbit 2019 Dec 15;38(6):495-499. Epub 2019 Jan 15.

Ophthalmology Department, Sapienza University , Rome , Italy.

We present the case of an ulcerative lesion of the eyelid as first presentation of type A lymphomatoid papulosis (LP) in a young adult. LP is a rare cutaneous lymphoproliferative disease with a risk of associated systemic or cutaneous lymphoma. Read More

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http://dx.doi.org/10.1080/01676830.2018.1563198DOI Listing
December 2019
10 Reads

The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas.

Blood 2019 04 11;133(16):1703-1714. Epub 2019 Jan 11.

Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Primary cutaneous lymphomas are a heterogeneous group of T- and B-cell lymphomas that present in the skin with no evidence of extracutaneous disease at the time of diagnosis. The 2005 World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) consensus classification has served as a golden standard for the diagnosis and classification of these conditions. In September 2018, an updated version of the WHO-EORTC was published in the fourth edition of the WHO Classification of Skin Tumours Blue Book. Read More

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http://dx.doi.org/10.1182/blood-2018-11-881268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473500PMC
April 2019
68 Reads