1,005 results match your criteria Lymphomatoid Papulosis


A Case of Tofacitinib-Induced Lymphomatoid Papulosis With Ocular Involvement.

Am J Dermatopathol 2022 May 3. Epub 2022 May 3.

Department of Dermatology, Oregon Health and Science University, Portland, OR.

Abstract: Janus kinase (JAK) inhibitors are being prescribed with increasing regularity in dermatology. We report on a patient who initiated treatment with tofacitinib for refractory erythema elevatum diutinum and subsequently developed a novel cutaneous outbreak characterized by firm violaceous papules on the trunk and extremities along with conjunctival injection and periorbital inflammation. Biopsy of affected tissue from both the cutaneous and ophthalmologic sources demonstrated increased numbers of CD30+ large atypical cells amid a mixed inflammatory cell infiltrate, consistent with lymphomatoid papulosis. Read More

View Article and Full-Text PDF

Aggressive Primary Cutaneous Anaplastic T-Cell Lymphoma Successfully Treated with Autologous Stem Cell Transplant and Brentuximab Vedotin Consolidation: Case Report and Review of the Literature.

Hematol Rep 2022 Mar 23;14(2):61-66. Epub 2022 Mar 23.

Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, Italy.

Primary cutaneous CD30+ lymphoproliferative disorders include primary cutaneous anaplastic large cell lymphoma (pcALCL) and lymphomatoid papulosis. The prognosis of the disease is usually excellent but, in a minority of cases, it presents with extracutaneous involvement and aggressive behavior. The case we present-relapsed after surgical excision, immunosuppressive therapy, and conventional chemotherapy-is the first one treated with Autologous Stem Cell transplant followed by Brentuximab Vedotin consolidation, a scheme already used for high risk Hodgkin Lymphoma. Read More

View Article and Full-Text PDF

Clinicopathological Factors Associated with the Prognosis and Chronicity of Lymphomatoid Papulosis: A Retrospective Cohort Study.

Clin Lymphoma Myeloma Leuk 2022 Feb 24. Epub 2022 Feb 24.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88, Songpa-gu, Seoul, Korea. Electronic address:

Background: The clinical and pathological features of lymphomatoid papulosis (LYP) are diverse. The objective of this study is to evaluate the clinical and pathological features associated with the prognosis and clinical course of LYP.

Patients And Methods: The clinical and pathological features of LYP in a medical center database were retrospectively retrieved. Read More

View Article and Full-Text PDF
February 2022

Remittance of primary cutaneous CD30 lymphoproliferative disorder in a patient on adalimumab.

JAAD Case Rep 2022 Apr 10;22:34-37. Epub 2022 Feb 10.

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

View Article and Full-Text PDF

Understanding Cell Lines, Patient-Derived Xenograft and Genetically Engineered Mouse Models Used to Study Cutaneous T-Cell Lymphoma.

Cells 2022 02 9;11(4). Epub 2022 Feb 9.

Division of Dermatology, McGill University, Montreal, QC H4A 3J1, Canada.

Cutaneous T cell lymphoma (CTCL) is a spectrum of lymphoproliferative disorders caused by the infiltration of malignant T cells into the skin. The most common variants of CTCL include mycosis fungoides (MF), Sézary syndrome (SS) and CD30 Lymphoproliferative disorders (CD30 LPDs). CD30 LPDs include primary cutaneous anaplastic large cell lymphoma (pcALCL), lymphomatoid papulosis (LyP) and borderline CD30 LPD. Read More

View Article and Full-Text PDF
February 2022

Leg paralysis after photodynamic therapy for lymphomatoid papulosis: A case report.

Dermatol Ther 2022 May 26;35(5):e15394. Epub 2022 Feb 26.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy.

View Article and Full-Text PDF

Diagnostic Value of Plasmacytoid Dendritic Cells in Differentiating Pityriasis Lichenoides et Varioliformis Acuta From Lymphomatoid Papulosis.

Am J Dermatopathol 2022 Mar;44(3):174-178

Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, MA; and.

Abstract: Pityriasis lichenoides et varioliformis acuta (PLEVA) and lymphomatoid papulosis (LyP) can often demonstrate clinical and histopathologic overlap. A recent study demonstrated significant plasmacytoid dendritic cell (pDC) recruitment in lesions of PLEVA, whereas another study reported minimal pDC recruitment in lesions of LyP. To confirm the possible diagnostic value of pDCs in differentiating PLEVA and LyP, we compared the presence and distribution of pDCs and myxovirus protein A (MxA) expression (an indirect assessment of pDC activity). Read More

View Article and Full-Text PDF

Pediatric Cutaneous Hematologic Disorders: Cutaneous Lymphoma and Leukemia Cutis: Experience of a Tertiary-Care Pediatric Institution and Review of the Literature.

J Cutan Med Surg 2022 Feb 15:12034754221077694. Epub 2022 Feb 15.

Department of Pathology, Sainte-Justine University Hospital Center, University of Montreal, Montreal, Quebec, Canada.

Background: Cutaneous hematologic malignancies are rare in children, and the literature about them is still sparse.

Objective: The purpose of our study was to report our experience with pediatric cases of cutaneous hematologic disorders and describe their clinical and histological features.

Methods: Data were retrospectively collected from the histopathologic database of the CHU Sainte-Justine, University of Montreal, Montreal, Canada. Read More

View Article and Full-Text PDF
February 2022

Squamous Cell Carcinoma and Tattoo: A Man With a Tattoo-Associated Squamous Cell Carcinoma and Review of Benign Tumors, Lymphoid Conditions, and Malignant Neoplasms Occurring Within a Tattoo.

Authors:
Philip R Cohen

Cureus 2022 Jan 10;14(1):e21083. Epub 2022 Jan 10.

Dermatology, University of California, Davis Medical Center, Sacramento, USA.

Tattoos, a common form of body adornment, have been associated with numerous cutaneous complications. These include not only benign neoplasms and malignant tumors but also lymphoid conditions occurring within the tattoo. Tattoo-associated dermatomyofibroma, epidermoid inclusion cyst, hemangioma, lipoma, milia, and pilomatricoma are benign lesions that have each only been described in one individual. Read More

View Article and Full-Text PDF
January 2022

Lymphomatoid papulosis responding to topical methotrexate.

JAAD Case Rep 2022 Feb 14;20:31-33. Epub 2021 Dec 14.

Department of Dermatology, Hôpital de Chicoutimi, Chicoutimi, Canada.

View Article and Full-Text PDF
February 2022

Primary cutaneous CD8+ cytotoxic T-cell lymphoma of the face with intraoral involvement, resulting in facial nerve palsy after chemotherapy.

J Cutan Pathol 2022 Jan 9. Epub 2022 Jan 9.

Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, Brazil.

The primary cutaneous (PC) CD8+ T-cell lymphoproliferative disorders (LPDs) comprise clinically and histopathologically heterogeneous entities including mycosis fungoides, lymphomatoid papulosis, hydroa-vacciniforme-like LPD, subcutaneous panniculitis-like T-cell lymphoma (TCL), PC acral CD8+ TCL, PC CD8+ aggressive epidermotropic cytotoxic TCL, and PC peripheral TCL, not otherwise specified (PTCL-NOS). We describe a 33-year-old man who presented with progressive facial swelling and lower lip involvement 1 year ago. Microscopy revealed an atypical small to medium-sized lymphoid proliferation exhibiting perivascular accentuation, adnexotropism, and apoptotic cell debris, without surface epithelium involvement. Read More

View Article and Full-Text PDF
January 2022

Genomic Analysis of Cutaneous CD30-Positive Lymphoproliferative Disorders.

JID Innov 2022 Jan 15;2(1):100068. Epub 2021 Nov 15.

Department of Pathology, City of Hope National Medical Center, Duarte, California, USA.

Primary cutaneous CD30 T-cell lymphoproliferative disorders are the second most common cutaneous lymphomas. According to the World Health Organization, CD30 T-cell lymphoproliferative disorders include primary cutaneous anaplastic large cell lymphoma (C-ALCL) and lymphomatoid papulosis (LyP) as well as borderline lesions. C-ALCL and LyP are thought to represent two ends of a spectrum of diseases that have different clinical presentations, clinical courses, and prognoses in their classic forms but share the same histology of medium to large CD30 atypical lymphoid cell infiltrates. Read More

View Article and Full-Text PDF
January 2022

Rare lymphomatoid reactions following SARS-CoV-2 vaccination.

JAAD Case Rep 2022 Feb 14;20:26-30. Epub 2021 Dec 14.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Full-Text PDF
February 2022

Oncogenic Mutations and Gene Fusions in CD30-Positive Lymphoproliferations and Clonally Related Mycosis Fungoides Occurring in the Same Patients.

JID Innov 2021 Sep 15;1(3):100034. Epub 2021 Jun 15.

Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.

The emergence of a common progenitor cell has been postulated for the association of CD30-positive lymphoproliferative disease (LPD) and mycosis fungoides (MF) within the same patient. Up to now, no comprehensive analysis has yet addressed the genetic profiles of such concurrent lymphoma subtypes. We aimed to delineate the molecular alterations of clonally related CD30-positive LPD and MF occurring in the same two patients. Read More

View Article and Full-Text PDF
September 2021

Two Histologic Patterns of Lymphomatoid Papulosis Occurring in a Child: A Matter of Timing?

J Pediatr Hematol Oncol 2022 Apr;44(3):e775-e778

Dermatology Service, KK Women's & Children's Hospital, Singapore, Singapore.

There are several histologic patterns seen in lymphomatoid papulosis, with the possibility of different subtypes occurring in the same patient. We report a case of lymphomatoid papulosis presenting with 2 histologic subtypes (types A and B) occurring concomitantly in a 10-year-old child, and postulate that the different subtypes occur dependent on the age of the lesion biopsied. Incidentally, one of the biopsies also shows a rarely seen pattern of pseudoepitheliomatous hyperplasia in a pediatric lymphomatoid papulosis patient. Read More

View Article and Full-Text PDF

Primary Cutaneous Gamma-Delta T Cell Lymphomas: A Case Series and Overview of the Literature.

Dermatopathology (Basel) 2021 Nov 17;8(4):515-524. Epub 2021 Nov 17.

UOC Dermatologia, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Primary cutaneous gamma-delta T cell lymphomas (PCGDTCLs) are rare and aggressive cutaneous malignancies that have been diagnostically challenging for dermopathologists and clinicians since their first published descriptions in 1991. Since then, the availability of immunostaining for T cell receptors γ and δ in formalin-fixed paraffin-embedded samples has greatly increased our knowledge of the gamma-delta phenotype by showing that it may also be present in the context of indolent entities, such as mycosis fungoides (MFs) and lymphomatoid papulosis, and this has raised questions concerning its diagnostic and prognostic implications. We here describe the histological and clinical differences between the dermo-epidermal and subcutaneous sub-groups of PCGDTCL observed in a cohort of 20 patients attending a single experienced centre, with particular focus on cases with an MF-like presentation, which are still less well defined than those of classic MF. Read More

View Article and Full-Text PDF
November 2021

Lymphomatoid papulosis in a patient treated with glatiramer acetate and the glatiramoid Glatopa for multiple sclerosis: A case report.

J Cent Nerv Syst Dis 2021 20;13:11795735211053784. Epub 2021 Nov 20.

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA.

A 48-year-old Caucasian woman with history of multiple sclerosis (MS) presented with erythematous papulonodular lesions in her extremities and trunk. She was being treated with glatiramer acetate (GA) for the past 10 years and the glatiramoid, Glatopa, for 2 years prior to this presentation. A skin biopsy showed CD30 lymphoproliferative disorder consistent with lymphomatoid papulosis (LyP). Read More

View Article and Full-Text PDF
November 2021

Patch/plaque mycosis-fungoides-like presentations of DUSP22-translocated T-cell lymphomas.

J Cutan Pathol 2022 Mar 7;49(3):299-305. Epub 2021 Nov 7.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.

The DUSP22-IRF4 gene rearrangement results in downregulation of DUSP22, a presumed tumor suppressor in T-cell lymphomagenesis. It has been described in some cases of primary cutaneous and systemic anaplastic large-cell lymphoma, lymphomatoid papulosis, and transformed mycosis fungoides. Here we describe two patients with clinical lesions resembling patch/plaque mycosis fungoides that did not meet WHO criteria for large-cell transformation on histopathology yet showed a DUSP22 translocation. Read More

View Article and Full-Text PDF

Next-generation sequencing confirms T-cell clonality in a subset of pediatric pityriasis lichenoides.

J Cutan Pathol 2022 Mar 21;49(3):252-260. Epub 2021 Oct 21.

Department of Dermatology, Stanford University Medical Center, Stanford, California, USA.

Background: Pityriasis lichenoides (PL) is a papulosquamous disease that affects both adults and children. Previous studies have shown a subset of this entity to have clonal T-cell populations via PCR-based assays. In this study, we sought to implement next-generation sequencing (NGS) as a more sensitive and specific test to examine for T-cell clonality within the pediatric population. Read More

View Article and Full-Text PDF

Case Report: Contrasting BCL2 Upregulation With Venetoclax in a Case of Refractory Lymphomatoid Papulosis and Progressive Chronic Lymphocytic Leukemia.

Front Oncol 2021 9;11:729106. Epub 2021 Sep 9.

Institute of Hematology-Centro di Ricerca Emato-Oncologica (CREO), Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

A 57-year-old man affected by high-risk progressive chronic lymphocytic leukemia (CLL), primary resistant to first-line chemoimmunotherapy, developed a type A lymphomatoid papulosis (LyP) during a second progression of CLL. The two blood tumor entities were clonally unrelated. LyP presented with a diffuse (>90% body surface area) cutaneous rash and was characterized by intensely pruriginous dusky nodules (n = 10) and red flat-topped papules (n = 60). Read More

View Article and Full-Text PDF
September 2021

Pseudomalignancies in Children: Histological Clues, and Pitfalls to Be Avoided.

Dermatopathology (Basel) 2021 Aug 14;8(3):376-389. Epub 2021 Aug 14.

Department of Pathology, Hôpital Necker-Enfants Malades, APHP, 75015 Paris, France.

The term "pseudomalignancy" covers a large, heterogenous group of diseases characterized by a benign cellular proliferation, hyperplasia, or infiltrate that resembles a true malignancy clinically or histologically. Here, we (i) provide a non-exhaustive review of several inflammatory skin diseases and benign skin proliferations that can mimic a malignant neoplasm in children, (ii) give pathologists some helpful clues to guide their diagnosis, and (iii) highlight pitfalls to be avoided. The observation of clinical-pathological correlations is often important in this situation and can sometimes be the only means (along with careful monitoring of the disease's clinical course) of reaching a firm diagnosis. Read More

View Article and Full-Text PDF

Lymphomatoid Papulosis Development in Acute Lymphoblastic Leukemia.

J Med Cases 2021 Aug 3;12(8):306-309. Epub 2021 Jul 3.

Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan.

Lymphomatoid papulosis (LyP) is a chronic, recurrent benign skin disease characterized by histological features of a CD 30-positive cutaneous T-cell lymphoproliferative disorder. It is rare, with an annual, worldwide incidence of 1.2 - 1. Read More

View Article and Full-Text PDF

The incidences of other primary cancers in patients with mycosis fungoides and Sézary syndrome.

Postepy Dermatol Alergol 2021 Apr 22;38(2):289-294. Epub 2021 May 22.

Department of Dermatology, Venereology, and Allergology, Medical University of Gdansk, Gdansk, Poland.

Introduction: Cutaneous T-cell lymphomas (CTCLs) are a diverse group of non-Hodgkin's lymphomas with malignant T lymphocytes infiltrating the skin. Mycosis fungoides (MF) and Sézary syndrome (SS) belong to the group of CTCLs, among others. In previous studies it was suggested that primary cancers more often occur in patients with cutaneous lymphoma. Read More

View Article and Full-Text PDF

Exuberant Lymphomatoid Papulosis of the Head and Upper Trunk.

Cutis 2021 May;107(5):E12-E15

Dr. Hemperly is from the Dermatology Residency Program, Lehigh Valley Health Network, Allentown, Pennsylvania. Drs. Lountzis and Purcell are from Advanced Dermatology Associates, Ltd, Allentown.

View Article and Full-Text PDF

Lymphomatoid papulosis mimicking distal embolism.

Int J Dermatol 2021 Jul 14. Epub 2021 Jul 14.

Department of Dermatology, Hospital Universitario 12 de Octubre, Madrid, Spain.

View Article and Full-Text PDF

Primary Cutaneous Lymphomas in Thailand: A 10-Year Retrospective Study.

Biomed Res Int 2021 11;2021:4057661. Epub 2021 Jun 11.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Background: Primary cutaneous lymphomas (PCLs) refer to cutaneous lymphomas that primarily develop in the skin with no evidence of extracutaneous disease at the time of diagnosis. The epidemiological and clinical data of PCLs in Thailand are lacking.

Objectives: To evaluate the frequency, demographic data, and clinical characteristics of different subtypes of PCLs in a tertiary care university hospital. Read More

View Article and Full-Text PDF
October 2021

Recurrent and Persistent Lymphomatoid Papulosis in an Elderly Male with Hodgkin's Lymphoma.

Am J Med 2021 11 29;134(11):1362-1364. Epub 2021 Jun 29.

Department of Pathology, All India Institute of Medical Sciences, Jodhpur, India.

View Article and Full-Text PDF
November 2021

Primary cutaneous anaplastic large-cell lymphoma with 6p25.3 rearrangement exhibits a biphasic histopathologic pattern: Two case reports and literature review.

J Cutan Pathol 2021 Dec 21;48(12):1463-1470. Epub 2021 Jul 21.

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China.

Background: Primary cutaneous CD30+ lymphoproliferative diseases are the second most common group of cutaneous T-cell lymphomas, including lymphomatoid papulosis (LyP), primary cutaneous anaplastic large-cell lymphoma (pcALCL), and borderline cases. These diseases form a spectrum and may show overlapping histopathological, phenotypic, and genetic features. In the 2016 WHO classification, LyP with 6p25. Read More

View Article and Full-Text PDF
December 2021