1,873 results match your criteria Lymphomatoid Papulosis


CD30+ T-cell lymphoproliferative disorders.

Chin Clin Oncol 2018 Oct 11. Epub 2018 Oct 11.

Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.

The term "CD30+ T-cell lymphoproliferative disorders" describes a group of diverse diseases of the skin, subcutaneous tissues and mucosa that range from lesions requiring clinical observation to those necessitating systemic cytotoxic chemotherapy. Careful consideration of both clinical and histopathologic presentation is needed for appropriate diagnosis and treatment. This review will present the current classification of these disorders and potential treatment paradigms. Read More

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October 2018

CD8-positive lymphomatoid papulosis (type D): Some lesions may lack CD30 expression and overlap histologically with mycosis fungoides.

Int J Dermatol 2018 Dec 6. Epub 2018 Dec 6.

School of Medicine, Indiana University, Indianapolis, IN, USA.

Background: CD8 lymphomatoid papulosis is frequently indistinguishable histopathologically from primary cutaneous aggressive epidermotropic CD8 T-cell lymphoma except for the expression of CD30. However, absent or weak expression of CD30 has been rarely reported in cases of CD8 LyP.

Objective: We aim to study the clinical and pathologic features of cases of CD8 LyP with no or minimal expression of CD30. Read More

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December 2018

Late cutaneous B-Cell pseudolymphoma after an upper-lid gold weight implant.

Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Hospital Universitario Príncipe de Asturias, Madrid, Spain.

Upper eyelid gold weight implants are an established tool in the symptomatic treatment of lagophthalmos, the inability to close your eyes completely. Complications associated to this procedure are infrequent. When noted, non-infectious inflammatory reactions corresponding to type IV hypersensitivity reactions are resolved with the removal of the implant. Read More

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December 2018
2 Reads

[Lymphomatoid gastropathy: one case report and literatures review].

Zhonghua Xue Ye Xue Za Zhi 2018 Nov;39(11):937-941

Department of Internal Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinsese Academy of Medical Sciences, Beijing 100730, China.

To report the first case of lymphomatoid gastropathy in China, and to demonstrate the clinical characteristics, diagnostic approach, treatment and prognosis in this kind of patients. One patient was diagnosed as lymphomatoid gastropathy at Peking Union Medical College Hospital, and her clinical characteristics, lab data, treatment and follow-up outcomes were reviewed. A case of a 51-year-old female was presented, who underwent esophagogastroduodenoscopy (EGD) due to slight epigastric discomfort. Read More

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November 2018
1 Read

Biphasic pathologic pattern in transformed mycosis fungoides not associated with DUSP22-IRF4 translocation.

Histopathology 2018 Nov 20. Epub 2018 Nov 20.

Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Dermatology Department, Centre Hospitalier Estaing, 1 place Lucie Aubrac, 63100, Clermont-Ferrand, France.

Large-cell transformation in mycosis fungoides (MF) is usually encountered in tumors and is associated with prognosis worsening. It is defined by the onset of more than 25% of lymphocytes, usually expressing CD30, exceeding 4 times the size of normal lymphocytes, either diffuse or organized in sheets in the dermal infiltrate. Recently, an unusual biphasic pathologic pattern was reported in lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (ALCL) which was constantly associated with DUSP22-IRF4 gene rearrangement . Read More

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November 2018
1 Read

Antibody-Based Therapies for Cutaneous T-Cell Lymphoma.

Am J Clin Dermatol 2018 Nov 15. Epub 2018 Nov 15.

University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1452, Houston, TX, 77030-4009, USA.

Cutaneous T-cell lymphomas (CTCLs) are a group of non-Hodgkin's lymphomas that present in the skin. In early-stage disease, the course is generally chronic and indolent; however, in advanced stages of disease, therapies rarely provide long-lasting responses, and the only potential curative therapy is allogeneic hematopoietic stem-cell transplantation. This has led to the search for novel targeted therapies to better treat more advanced stages of CTCLs that cannot be controlled by typical treatment regimens. Read More

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November 2018
4 Reads

Common origin of sequential cutaneous CD30+ lymphoproliferations with nodal involvement evidenced by genome-wide clonal evolution.

Histopathology 2018 Nov 4. Epub 2018 Nov 4.

Department Predictive Oncology, Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm, U1068, Marseille, France, CNRS, UMR7258, Marseille, Institut Paoli-Calmettes, Marseille, France, Aix-Marseille University, UM 105Marseille, France.

Aims: Molecular pathways underlying the putative evolution from lymphomatoid papulosis (LyP) to cutaneous anaplastic large cell lymphoma (c-ALCL) and lymph node invasion (LNI) remain elusive.

Methods And Results: To clarify this point, we analyzed nine sequential tumors from the same patient presenting a parallel evolution of LyP (n=3) and c-ALCL (n=1) with LNI (n=1) combined with systemic diffuse large B-cell lymphoma (DLCL) (n=4). Clonality analysis showed a common clonal T-cell origin in the five CD30+ lesions and a common clonal B-cell origin in the four DLCL relapses. Read More

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November 2018
14 Reads

Long-term Follow-up of a Case of Lymphomatoid Papulosis with a Benign Course.

Acta Dermatovenerol Croat 2018 Oct;26(3):264-266

Jaka Radoš, MD, University Hospital Centre Zagreb Department of Dermatology and Venereology School of Medicine University of Zagreb Šalata 4, 10000 Zagreb , Croatia;

Dear Editor,We present the case of a 40-year old male patient with lymphomatoid papulosis of a waxing and waning course on whom three biopsies were performed during a 14-year period with no change in histopathological or immunophenotypical characteristics. Lymphomatoid papulosis (LP) is a chronic, recurrent, self-healing papulonodular skin eruption with the histopathologic features of a cutaneous T-cell lymphoma but an often benign and indolent clinical course (1). It is designated as a primary, cutaneous, CD30+ lymphoproliferative disorder. Read More

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October 2018
12 Reads

Type B lymphomatoid papulosis.

Pan Afr Med J 2018;30:138. Epub 2018 Jun 18.

Department of Dermatology, Ibn Sina University Hospital, Rabat, Morocco.

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June 2018
1 Read

Lymphomatoid granulomatosis: a rare lymphoproliferative disease in the pediatric age.

Radiologia 2018 Oct 15. Epub 2018 Oct 15.

Servicio de Radiodiagnóstico, Hospital Universitario Virgen del Rocío, Sevilla, España.

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October 2018
3 Reads

Case 259: Primary Central Nervous System Lymphomatoid Granulomatosis Mimicking Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS).

Radiology 2018 Nov;289(2):572-577

From the Bejing-TJ Center for Neuroinflammation, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (D.T.); Department of Neurology, Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, China (X.Z., R.X., P.Z.); and Department of Neurology, Guizhou Provincial People's Hospital, Medical School of Guizhou University, Zhongshan East Road 83, Guiyang 550002, China (Y.Y.).

History In November 2012, a previously healthy 31-year-old woman was admitted to our hospital with a 2-month history of right-sided numbness, diplopia, and intermittent nausea and dizziness. She did not have a history of fever, weight loss, headache, photophobia, seizure, or extremity weakness. Physical examination revealed left abduction limitation and right-sided hypoesthesia. Read More

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November 2018
2 Reads

Phototherapy of cutaneous T-cell lymphomas.

Authors:
Franz Trautinger

Photochem Photobiol Sci 2018 Dec;17(12):1904-1912

Department of Dermatology and Venereology, Karl Landsteiner University of Health Sciences, University Hospital of St. Pölten, Austria.

Cutaneous T-cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas arising in the skin. Mycosis fungoides (MF), the most common variant, is characterised by clonal proliferation of skin residing malignant T-cells. Initially appearing with erythematous patches and plaques it follows a chronic course with progression to cutaneous tumours and extracutaneous involvement in some patients. Read More

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December 2018
6 Reads

Pediatric oral Epstein-Barr virus associated self-remitting CD30+ lymphoproliferative disorder: A distinct entity.

Ann Diagn Pathol 2018 Sep 12;37:57-61. Epub 2018 Sep 12.

Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address:

Epstein-Barr virus (EBV) has a well-known association with lymphoproliferative disorders of B and T cell origin. EBV-related B cell lymphoproliferative disorders include Hodgkin and Burkitt lymphomas, lymphomatoid granulomatosis, EBV positive diffuse large cell B cell lymphoma of the elderly, as well as B cell lymphomas associated with solid organ transplantation and methotrexate use. EBV-related T cell disorders are primarily represented by NK/T- cell lymphoma. Read More

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September 2018
5 Reads

Lymphomatoid granulomatosis mimicking cancer and sarcoidosis.

Ann Hematol 2018 Oct 5. Epub 2018 Oct 5.

Institute of Pathology and Molecular Pathology, University Hospital Zurich, Rämistrasse 100, 8091, Zürich, Switzerland.

Two cases of misdiagnoses of lymphomatoid granulomatosis are discussed here. Lymphomatoid granulomatosis is an Epstein-Barr virus-associated lymphoproliferative disorder with aggressive behavior. Due to its rarity and many presentations, delay in diagnosis and treatment is common. Read More

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October 2018
2 Reads

Oral ulceration: an unusual manifestation of lymphomatoid granulomatosis.

Ann Hematol 2018 Oct 3. Epub 2018 Oct 3.

Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501, Japan.

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October 2018
2 Reads

The Alphabetization of Lymphomatoid Papulosis: Focus on "F".

Authors:
Warren R Heymann

Skinmed 2018 1;16(4):259-260. Epub 2018 Jul 1.

From the Division of Dermatology, Department of Medicine and Department of Pediatrics, Cooper Medical School of Rowan University, Marlton, NJ;

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Cutaneous Lymphoproliferative Disorders: What's New in the Revised 4th Edition of the World Health Organization (WHO) Classification of Lymphoid Neoplasms.

Authors:
Uma Sundram

Adv Anat Pathol 2018 Sep 7. Epub 2018 Sep 7.

Department of Anatomic Pathology, Oakland University William Beaumont School of Medicine and Beaumont Health Systems, Royal Oak, MI.

Cutaneous lymphoproliferative disorders remain a challenging aspect of dermatopathology, in part due to the rarity of the entities and extreme variability in clinical outcomes. Although many of the entities remain unchanged, the approach to some of them has changed in the new 2016 classification scheme of the World Health Organization. Chief among these are Epstein-Barr virus-associated lymphoproliferative disorders such as Epstein-Barr virus-associated mucocutaneous ulcer and hydroa vacciniforme-like lymphoproliferative disorder, primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma, primary cutaneous acral CD8+ T-cell lymphoma, primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder, and breast implant-associated anaplastic large cell lymphoma. Read More

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September 2018
7 Reads

A case of lymphomatoid papulosis, pityriasis lichenoides acuta, and mycosis fungoides coexistence.

Australas J Dermatol 2018 Sep 9. Epub 2018 Sep 9.

Department of Dermatology, Cutaneous Lymphoma Clinic, "Andreas Sygros" Hospital, University of Athens Medical School, Athens, Greece.

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September 2018
2 Reads

Local radiation for cutaneous T-cell lymphoma other than mycosis fungoides and Sézary syndrome.

Authors:
Naoto Shikama

Chin Clin Oncol 2018 Jul 19. Epub 2018 Jul 19.

Department of Radiation Oncology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 Japan.

Primary cutaneous lymphoma is the second most common type of extranodal lymphoma. The clinical behavior of this lymphoma differs from that of other extranodal lymphomas and thus requires a particular pretreatment evaluation and treatment strategy. Cutaneous T-cell lymphoma (CTCL) accounts for 80% of primary cutaneous lymphoma cases and includes several confirmed disease entities as well as provisional entities. Read More

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July 2018
2 Reads

Lymphomatoid papulosis in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma: case report and literature review.

Dermatol Online J 2018 May 15;24(5). Epub 2018 May 15.

Department of Internal Medicine, University of California San Diego, La Jolla, California.

Background: Chronic lymphocytic leukemia (CLL) is a B cell lymphoproliferative disorder that characteristically presents in older individuals. Small lymphocytic lymphoma (SLL) occurs when CLL cells infiltrate lymph nodes and other tissues but spare peripheral blood and bone marrow. Lymphomatoid papulosis (LyP) is an indolent cutaneous CD30+ lymphoproliferative disorder characterized by papules and nodules that develop and spontaneously regress over weeks to months. Read More

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May 2018
12 Reads

Unique case of trigeminal neuralgia due to Epstein-Barr-virus-associated B-cell lymphomatoid granulomatosis of the Meckel's cave and cavernous sinus: Important clinical and therapeutic implications.

Surg Neurol Int 2018 26;9:148. Epub 2018 Jul 26.

Department of Neurosurgery, Mainz University Hospital, Langenbeckstraße 1, 55131 Mainz, Germany.

Background: Trigeminal neuralgia (TN) represents one of the most disabling pain syndromes. Several diseases have been described as etiological triggers of TN, vascular compression of the trigeminal nerve being the most frequent cause. Here, we describe for the first time a rare case of TN caused by an infiltration of an isolated Epstein-Barr virus (EBV) B-cell lymphomatoid granulomatosis (LYG) mass into the Meckel's cave and cavernous sinus. Read More

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July 2018
3 Reads

Cutaneous lymphomatoid granulomatosis with long-term absence of lung involvement.

J Dermatol 2018 Jul 16. Epub 2018 Jul 16.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

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July 2018
3 Reads

Unusual Manifestations of Secondary Syphilis: Case Presentations.

Acta Dermatovenerol Croat 2018 Jun;26(2):186-188

Sorina Ana Dănescu, MD, University of Medicine and Pharmacy "Iuliu Hatieganu", Victor Babes 8 street, Cluj-Napoca, Cluj, Romania;

Dear Editor, Syphilis is an infection caused by Treponema pallidum. Without treatment, it goes through the following stages: primary, secondary, latent, and tertiary (1). The clinical picture of secondary syphilis is very variable (2,3). Read More

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June 2018
16 Reads

[Clinicopathologic features of primary mucosal CD30-positive T-cell lymphoproliferative disorders in head and neck region].

Zhonghua Bing Li Xue Za Zhi 2018 Jun;47(6):412-416

Department of Pathology, Sun Yat-Sen University Foshan Hospital, Foshan 528000, China.

To study clinicopathologic features, prognosis and differential diagnoses of primary mucosal CD30-positive T-cell lymphoproliferative disorders of the head and neck(mCD30(+) TLPD-head and neck). Three cases of mCD30(+) TLPD-head and neck were collected from January 2014 to April 2017 at Sun Yat-Sen University Foshan Hospital. A literature review of mCD30(+) TLPD of head and neck was provided. Read More

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June 2018
11 Reads

Pitfall of F-FDG PET/CT in Characterization of Relapsed Multisystem Lymphomatoid Granulomatosis.

J Nucl Med Technol 2018 Dec 8;46(4):396-397. Epub 2018 Jun 8.

Department of Radiology, Mayo Clinic Arizona, Scottsdale, Arizona

We present serial F-FDG PET/CT findings in a case of grade 3 pulmonary lymphomatoid granulomatosis positive for the Epstein-Barr virus. The patient experienced a transient complete response to R-CHOP chemotherapy and subsequent multisystem recurrence, predominately involving the subcutaneous region of the torso on F-FDG PET/CT. Biopsy of the most hypermetabolic subcutaneous lesion demonstrated grade 1 cutaneous lymphomatoid granulomatosis negative for the Epstein-Barr virus. Read More

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December 2018
2 Reads

[Primary cutaneous lymphoma-a case series of 163 patients].

Hautarzt 2018 Jun 7. Epub 2018 Jun 7.

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Freiburg, Deutschland.

Background: In addition to a broad and clinically diverse spectrum of known primary cutaneous lymphomas, for which an incidence of 1-3:100,000 is postulated, each year further entities are specified and defined. The goal is the presentation of a case series from daily clinical routine.

Methods: Over a period of 6 years and 2 months, patients consulting the Department of Dermatology, Medical Center University of Freiburg, were registered. Read More

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June 2018
8 Reads

The Spontaneous Regression of Grade 3 Methotrexate-related Lymphomatoid Granulomatosis: A Case Report and Literature Review.

Intern Med 2018 Nov 6;57(21):3163-3167. Epub 2018 Jun 6.

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan.

Lymphomatoid granulomatosis (LYG) is a rare lung disorder diagnosed by radiological imaging of multiple pulmonary nodules and occasionally induced by methotrexate (MTX) use. To date, the treatment of LYG has not been standardized. We herein report the case of a patient with grade 3 MTX-related LYG who presented a bulky lung mass. Read More

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November 2018
3 Reads

Lymphomatoid Granulomatosis with Isolated Cutaneous Lesions: Prolonged Remission After DA-EPOCH Protocol

Turk J Haematol 2018 08 1;35(3):213-214. Epub 2018 Jun 1.

All India Institute of Medical Sciences, Department of Medical Oncology, New Delhi, India

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August 2018
1 Read
0.340 Impact Factor

Pityriasis Lichenoides, Atypical Pityriasis Lichenoides, and Related Conditions: A Study of 66 Cases.

Am J Surg Pathol 2018 Aug;42(8):1101-1112

Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Pityriasis lichenoides (PLs) is an uncommon skin disease of unknown etiology. In recent years, an atypical form of PL has been described, showing overlapping features with mycosis fungoides (MF) and lymphomatoid papulosis. We studied 66 patients with an initial histopathologic diagnosis of PL (M:F=34:32; median age, 25 y; range, 7 to 85 y). Read More

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August 2018
3 Reads

Clinical evolution of lymphomatoid papulosis.

Br J Haematol 2018 Sep 29;182(6):756. Epub 2018 May 29.

Department of Dermatology, Salford Royal NHS Foundation Trust, Salford, UK.

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September 2018

Dermal xanthomatous infiltrates after brentuximab vedotin therapy in mycosis fungoides with large-cell transformation: A novel histologic finding.

J Cutan Pathol 2018 May 27. Epub 2018 May 27.

Section of Dermatopathology, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Mycosis fungoides (MF) is the most common variant of cutaneous T-cell lymphomas. Large-cell transformation of MF has been associated with disease progression and overall poor outcome. The expression of CD30, which defines anaplastic large cell lymphoma (ALCL) and lymphomatoid papulosis, might also occur in a subset of patients with MF, with or without large-cell transformation. Read More

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May 2018
5 Reads

Lymphomatoid Papulosis (LyP) Associated with Diffuse Large B-cell Lymphoma and Cutaneous Anaplastic Large Cell Lymphoma: LyP as a Haematological Malignancy-related Dermadrome.

Acta Derm Venereol 2018 Aug;98(8):799-800

Department of Dermatology, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.

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August 2018
7 Reads

Cartilage hair hypoplasia with cutaneous lymphomatoid granulomatosis.

Clin Exp Dermatol 2018 Aug 10;43(6):713-717. Epub 2018 May 10.

Department of Pathology, Birmingham Children's Hospital, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia characterized by short-stature, sparse hair and impaired cellular immunity. We describe a young girl who was diagnosed with CHH based on the findings of recurrent infections, short stature with metaphyseal chondrodysplasia, and a confirmed bi-allelic RMRP gene mutation. At 13 years, the patient developed an Epstein-Barr virus (EBV)-driven lymphoproliferative disorder involving the lung, which responded partially to chemotherapy. Read More

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August 2018
1 Read

Angiocentric lymph proliferative disorder (lymphomatoid granulomatosis) in a person with newly-diagnosed HIV infection: a case report.

BMC Infect Dis 2018 05 8;18(1):210. Epub 2018 May 8.

Division of Infectious Diseases and Chronic Viral Illness Service, McGill University Health Centre, Royal Victoria Hospital, Glen Site, 1001 boulevard Decarie, Montreal, QC, H4A 3J1, Canada.

Background: Angiocentric lymph proliferative disorder (ALPD) is a granulomatous lymphoproliferative condition associated with various primary and secondary immunodeficiency states. ALPD is so rare that its prevalence has not been established. Typically affecting middle-aged adults, this condition is often found in the context of Epstein Bar Virus infection and consists of angiocentric and angioinvasive pulmonary infiltrates. Read More

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May 2018
2 Reads

Cutaneous CD30-positive T-cell lymphoproliferative disorders-clinical and histopathologic features, differential diagnosis, and treatment.

Semin Cutan Med Surg 2018 Mar;37(1):24-29

Department of Dermatology, University Medical Center, Göttingen, Germany.

Cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ LPD) are the second most common form of cutaneous T-cell lymphoma. CD30+ LPD include lymphomatoid papulosis, primary cutaneous anaplastic large-cell lymphoma, and borderline lesions. Despite expression of CD30 by the neoplastic cells as the hallmark of these disorders, they differ in their clinical presentation and histological features as well as the course, the prognosis, and consecutively in the treatment. Read More

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March 2018
3 Reads

Primary pulmonary lymphoproliferative neoplasms.

Lung India 2018 May-Jun;35(3):220-230

Department of Internal Medicine, Divisions of Critical Care, Pulmonary and Sleep Medicine, UT Health- McGovern Medical School, Houston, Texas, USA.

Pulmonary lymphoproliferative neoplasms are rare lung tumors and account for <1% of all lung tumors. Among them, primary pulmonary lymphomas (PPL) constitute the majority, which include Non-Hodgkin's lymphoma (NHL) that comprise of mucosa-associated lymphoid tissue lymphoma, diffuse large B-cell lymphomas and other rare types of NHL and lymphomatoid granulomatosis. HL, which arises secondary to contiguous spread from the mediastinum, is the rarest type of PPL. Read More

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April 2018
1 Read

The First Year of the AEVD Primary Cutaneous Lymphoma Registry.

Actas Dermosifiliogr 2018 Sep 19;109(7):610-616. Epub 2018 Apr 19.

Servicio de Dermatología, Hospital Universitario 12 de Octubre, Institute i+12, Medical School. Universidad Complutense, ONCOCIBER, Madrid, España.

Background And Objective: Primary cutaneous lymphomas are uncommon. This article describes the Primary Cutaneous Lymphoma Registry of the Spanish Academy of Dermatology and Venereology (AEDV) and reports on the results from the first year.

Patients And Methods: Disease registry for patients with primary cutaneous lymphoma. Read More

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September 2018
4 Reads

Lymphomatoid granulomatosis: A case series from South India.

Indian J Pathol Microbiol 2018 Apr-Jun;61(2):228-232

Department of Pathology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.

Context: Lymphomatoid granulomatosis (LYG) is a rare B-lymphoproliferative disorder characterised by an angiocentric and angiodestructive pattern along with Epstein - Barr virus (EBV) association. It is one of the diagnostic challenges in lymphoma pathology. Deregulation of EBV immune surveillance is one of the narrated hypotheses in the literature. Read More

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October 2018
16 Reads
0.642 Impact Factor

Lymphomatoid papulosis presenting as a rash in a patient with HIV infection.

Int J STD AIDS 2018 Nov 17;29(11):1120-1122. Epub 2018 Apr 17.

3 Department of Histopathology, University Hospital of Wales, Cardiff, UK.

A 43-year-old Malaysian man with well-controlled HIV infection on combination antiretroviral therapy presented with a six-week history of a widespread rash. The patient was otherwise well but was developing new lesions on a daily basis. Referral to Dermatology instigated punch biopsies, which revealed a diagnosis of lymphomatoid papulosis type A. Read More

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November 2018
5 Reads

Lymphomatoid papulosis with folliculotropism, eccrinotropism and neurotropism.

J Cutan Pathol 2018 Jul 15;45(7):530-534. Epub 2018 May 15.

Department of Dermatology, Chinese PLA General Hospital & Medical School, Beijing, China.

The histopathological characteristics of lymphomatoid papulosis (LyP) vary. Currently, 6 subtypes have been reported, including a new subtype with perifollicular infiltration and different degrees of folliculotropism of CD30+ atypical lymphocytes, known as follicular LyP. However, LyP pathologically manifesting with folliculotropism, eccrinotropism and neurotropism has been rarely reported. Read More

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July 2018
4 Reads

Primary lymphomatoid granulomatosis in the central nervous system: A report of three cases.

Neuropathology 2018 Apr 10. Epub 2018 Apr 10.

Department of Pathology, Seoul National University, College of Medicine, Seoul, Korea.

Lymphomatoid granulomatosis (LYG) is a rare lymphoproliferative disorder characterized by infiltration of Epstein-Barr virus (EBV)-positive large atypical B-cells in an angiocentric fashion in a mixed inflammatory background. The histologic spectrum of LYG ranges from reactive proliferation to diffuse large B-cell lymphoma according to the number of EBV+ B-cells. It is known that virtually all patients have pulmonary involvement, whereas primary LYG of the other organs has been rarely reported. Read More

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April 2018
11 Reads

Oral Manifestation of Lymphomatoid Granulomatosis.

Head Neck Pathol 2018 Mar 14. Epub 2018 Mar 14.

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.

Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder driven by Esptein-Barr virus (EBV) that most commonly affects the lungs, although extra pulmonary sites like the central nervous system, skin, liver and kidney can also be involved. It is microscopically characterized by an angiocentric and angiodestructive growth pattern, predominantly composed by small T-cells, although a smaller population of atypical large B-cells is considered the true neoplastic component. Oral cavity involvement of LYG has rarely been described and the diagnosis of this neoplasm is very difficult. Read More

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March 2018
5 Reads

EBV-Positive Lymphoproliferations of B- T- and NK-Cell Derivation in Non-Immunocompromised Hosts.

Pathogens 2018 Mar 7;7(1). Epub 2018 Mar 7.

Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, University Hospital Tübingen, Eberhard-Karls-University, 72076 Tübingen, Germany.

The contribution of Epstein-Barr virus (EBV) to the development of specific types of benign lymphoproliferations and malignant lymphomas has been extensively studied since the discovery of the virus over the last 50 years. The importance and better understanding of the EBV-associated lymphoproliferative disorders (LPD) of B, T or natural killer (NK) cell type has resulted in the recognition of new entities like EBV+ mucocutaneous ulcer or the addition of chronic active EBV (CAEBV) infection in the revised 2016 World Health Organization (WHO) lymphoma classification. In this article, we review the definitions, morphology, pathogenesis, and evolving concepts of the various EBV-associated disorders including EBV+ diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), EBV+ mucocutaneous ulcer, DLBCL associated with chronic inflammation, fibrin-associated DLBCL, lymphomatoid granulomatosis, the EBV+ T and NK-cell LPD of childhood, aggressive NK leukaemia, extranodal NK/T-cell lymphoma, nasal type, and the new provisional entity of primary EBV+ nodal T- or NK-cell lymphoma. Read More

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March 2018
3 Reads

SATB1 Defines a Subtype of Cutaneous CD30 Lymphoproliferative Disorders Associated with a T-Helper 17 Cytokine Profile.

J Invest Dermatol 2018 Aug 3;138(8):1795-1804. Epub 2018 Mar 3.

Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China; Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China. Electronic address:

Cutaneous CD30 lymphoproliferative disorders (LPDs), including lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large-cell lymphoma, comprise the second most common group of cutaneous T-cell lymphomas. Previously, we reported that special SATB1, a thymocyte-specific chromatin organizer, was overexpressed and promoted malignant T-cell proliferation in a portion of CD30 LPDs. Here, we investigated the expression pattern of SATB1 in CD30 LPDs with a large cohort of patient samples, and examined the potential of SATB1 as a molecular marker to classify CD30 LPDs with differential clinicopathological behaviors. Read More

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August 2018
11 Reads

Pityriasis lichenoides-like drug reaction: A clinical histopathologic study of 10 cases.

Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.

Background: Lymphomatoid drug reactions can mimic endogenous T and B cell lymphoproliferative diseases.

Objectives: We present a novel form of cutaneous drug reaction with features of pityriasis lichenoides (PL), a recognized form of T cell dyscrasia.

Methods: Ten cases were studied where a cutaneous eruption exhibiting semblance to PL within a few weeks to months after starting a particular drug. Read More

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November 2017
2 Reads