912 results match your criteria Lymphomatoid Granulomatosis


Primary lymphomatoid granulomatosis in the central nervous system: A report of three cases.

Neuropathology 2019 Mar 3. Epub 2019 Mar 3.

Department of Neurology, Centre Hospitalier de Saint-Denis, Hôpital Delafontaine, Saint-Denis, France.

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http://dx.doi.org/10.1111/neup.12546DOI Listing
March 2019
1 Read

The Role and Pitfall of F18-FDG PET/CT in Surveillance of High Grade Pulmonary Lymphomatoid Granulomatosis.

Curr Probl Diagn Radiol 2019 Feb 10. Epub 2019 Feb 10.

Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ.

Lymphomatoid granulomatosis (LYG) is an uncommon angiocentric and angiodestructive T-cell rich, Epstein-Barr virus (EBV) positive B-cell multisystem lymphoproliferative disorder, predominately affecting the lungs. Since both clinical presentation and radiographic imaging findings, including X-ray and computed tomographic (CT), are nonspecific, the ultimate diagnosis of LYG relies on lung tissue sample diagnosis with its WHO grading based on the degree of cytologic atypia, necrosis and density of EBV positive B-cells. In addition, its histopathologic grading is correlated with clinical manifestation with high grade LYG mimicking aggressive B-cell lymphoma. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2019.02.002DOI Listing
February 2019

Lymphomatoid Granulomatosis in a Patient with Chronic Lymphocytic Leukemia and Rapidly Progressing Peribronchovascular Pulmonary Infiltrates.

Case Rep Pulmonol 2019 21;2019:9870494. Epub 2019 Jan 21.

Wayne State University School of Medicine, Lymphoma Research Laboratory, 540 E Canfield Room No. 8829, Detroit, MI 48202, USA.

Lymphomatoid granulomatosis (LG) is an EBV-associated angiodestructive lymphoproliferative disease with multiorgan involvement that predominantly affects the lungs. We present a case of a 72-year-old man with a history of chronic lymphocytic leukemia who presented with upper respiratory symptoms and multiple erythematous skin papules. Chest CT showed ill-defined, irregular solid pulmonary nodules with peripheral ground-glass opacities in a peribronchovascular distribution. Read More

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http://dx.doi.org/10.1155/2019/9870494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363242PMC
January 2019
1 Read

Endobronchial Manifestation of Methotrexate-induced Lymphoproliferative Disorder.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Respiratory Medicine, Japanese Red Cross Wakayama Medical Center, Japan.

Lymphoproliferative disorders can occur in patients with autoimmune disorders who undergo long-term methotrexate therapy (MTX-LPD). Although the manifestations of MTX-LPD are diverse, little attention is paid to endobronchial involvement. We herein describe two patients with MTX-LPD who presented with parenchymal pulmonary tumors and endobronchial involvement of LPD; one had lymphomatoid gramulomatosis and the other LPD. Read More

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http://dx.doi.org/10.2169/internalmedicine.2109-18DOI Listing
February 2019

Lymphomatoid granulomatosis: a rare lymphoproliferative disease in the pediatric age.

Radiologia 2019 Mar - Apr;61(2):179-180. Epub 2018 Oct 15.

Servicio de Radiodiagnóstico, Hospital Universitario Virgen del Rocío, Sevilla, España.

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https://linkinghub.elsevier.com/retrieve/pii/S00338338183016
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http://dx.doi.org/10.1016/j.rx.2018.09.001DOI Listing
October 2018
5 Reads

Case 259: Primary Central Nervous System Lymphomatoid Granulomatosis Mimicking Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS).

Radiology 2018 Nov;289(2):572-577

From the Bejing-TJ Center for Neuroinflammation, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (D.T.); Department of Neurology, Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, China (X.Z., R.X., P.Z.); and Department of Neurology, Guizhou Provincial People's Hospital, Medical School of Guizhou University, Zhongshan East Road 83, Guiyang 550002, China (Y.Y.).

History In November 2012, a previously healthy 31-year-old woman was admitted to our hospital with a 2-month history of right-sided numbness, diplopia, and intermittent nausea and dizziness. She did not have a history of fever, weight loss, headache, photophobia, seizure, or extremity weakness. Physical examination revealed left abduction limitation and right-sided hypoesthesia. Read More

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http://pubs.rsna.org/doi/10.1148/radiol.2018161475
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http://dx.doi.org/10.1148/radiol.2018161475DOI Listing
November 2018
4 Reads

Pediatric oral Epstein-Barr virus associated self-remitting CD30+ lymphoproliferative disorder: A distinct entity.

Ann Diagn Pathol 2018 Dec 12;37:57-61. Epub 2018 Sep 12.

Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address:

Epstein-Barr virus (EBV) has a well-known association with lymphoproliferative disorders of B and T cell origin. EBV-related B cell lymphoproliferative disorders include Hodgkin and Burkitt lymphomas, lymphomatoid granulomatosis, EBV positive diffuse large cell B cell lymphoma of the elderly, as well as B cell lymphomas associated with solid organ transplantation and methotrexate use. EBV-related T cell disorders are primarily represented by NK/T- cell lymphoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183023
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http://dx.doi.org/10.1016/j.anndiagpath.2018.08.004DOI Listing
December 2018
8 Reads

Lymphomatoid granulomatosis mimicking cancer and sarcoidosis.

Ann Hematol 2018 Oct 5. Epub 2018 Oct 5.

Institute of Pathology and Molecular Pathology, University Hospital Zurich, Rämistrasse 100, 8091, Zürich, Switzerland.

Two cases of misdiagnoses of lymphomatoid granulomatosis are discussed here. Lymphomatoid granulomatosis is an Epstein-Barr virus-associated lymphoproliferative disorder with aggressive behavior. Due to its rarity and many presentations, delay in diagnosis and treatment is common. Read More

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http://link.springer.com/10.1007/s00277-018-3505-4
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http://dx.doi.org/10.1007/s00277-018-3505-4DOI Listing
October 2018
3 Reads

Oral ulceration: an unusual manifestation of lymphomatoid granulomatosis.

Ann Hematol 2018 Oct 3. Epub 2018 Oct 3.

Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501, Japan.

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http://link.springer.com/10.1007/s00277-018-3506-3
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http://dx.doi.org/10.1007/s00277-018-3506-3DOI Listing
October 2018
5 Reads

Unique case of trigeminal neuralgia due to Epstein-Barr-virus-associated B-cell lymphomatoid granulomatosis of the Meckel's cave and cavernous sinus: Important clinical and therapeutic implications.

Surg Neurol Int 2018 26;9:148. Epub 2018 Jul 26.

Department of Neurosurgery, Mainz University Hospital, Langenbeckstraße 1, 55131 Mainz, Germany.

Background: Trigeminal neuralgia (TN) represents one of the most disabling pain syndromes. Several diseases have been described as etiological triggers of TN, vascular compression of the trigeminal nerve being the most frequent cause. Here, we describe for the first time a rare case of TN caused by an infiltration of an isolated Epstein-Barr virus (EBV) B-cell lymphomatoid granulomatosis (LYG) mass into the Meckel's cave and cavernous sinus. Read More

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http://dx.doi.org/10.4103/sni.sni_12_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080144PMC
July 2018
5 Reads

Cutaneous lymphomatoid granulomatosis with long-term absence of lung involvement.

J Dermatol 2019 Feb 16;46(2):e69-e70. Epub 2018 Jul 16.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

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http://dx.doi.org/10.1111/1346-8138.14548DOI Listing
February 2019
5 Reads

Pitfall of F-FDG PET/CT in Characterization of Relapsed Multisystem Lymphomatoid Granulomatosis.

J Nucl Med Technol 2018 Dec 8;46(4):396-397. Epub 2018 Jun 8.

Department of Radiology, Mayo Clinic Arizona, Scottsdale, Arizona

We present serial F-FDG PET/CT findings in a case of grade 3 pulmonary lymphomatoid granulomatosis positive for the Epstein-Barr virus. The patient experienced a transient complete response to R-CHOP chemotherapy and subsequent multisystem recurrence, predominately involving the subcutaneous region of the torso on F-FDG PET/CT. Biopsy of the most hypermetabolic subcutaneous lesion demonstrated grade 1 cutaneous lymphomatoid granulomatosis negative for the Epstein-Barr virus. Read More

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http://dx.doi.org/10.2967/jnmt.118.212274DOI Listing
December 2018
7 Reads

The Spontaneous Regression of Grade 3 Methotrexate-related Lymphomatoid Granulomatosis: A Case Report and Literature Review.

Intern Med 2018 Nov 6;57(21):3163-3167. Epub 2018 Jun 6.

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan.

Lymphomatoid granulomatosis (LYG) is a rare lung disorder diagnosed by radiological imaging of multiple pulmonary nodules and occasionally induced by methotrexate (MTX) use. To date, the treatment of LYG has not been standardized. We herein report the case of a patient with grade 3 MTX-related LYG who presented a bulky lung mass. Read More

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http://dx.doi.org/10.2169/internalmedicine.0542-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262693PMC
November 2018
3 Reads

Lymphomatoid Granulomatosis with Isolated Cutaneous Lesions: Prolonged Remission After DA-EPOCH Protocol

Turk J Haematol 2018 08 1;35(3):213-214. Epub 2018 Jun 1.

All India Institute of Medical Sciences, Department of Medical Oncology, New Delhi, India

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http://dx.doi.org/10.4274/tjh.2018.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110445PMC
August 2018
6 Reads
0.340 Impact Factor

Cartilage hair hypoplasia with cutaneous lymphomatoid granulomatosis.

Clin Exp Dermatol 2018 Aug 10;43(6):713-717. Epub 2018 May 10.

Department of Pathology, Birmingham Children's Hospital, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia characterized by short-stature, sparse hair and impaired cellular immunity. We describe a young girl who was diagnosed with CHH based on the findings of recurrent infections, short stature with metaphyseal chondrodysplasia, and a confirmed bi-allelic RMRP gene mutation. At 13 years, the patient developed an Epstein-Barr virus (EBV)-driven lymphoproliferative disorder involving the lung, which responded partially to chemotherapy. Read More

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http://dx.doi.org/10.1111/ced.13543DOI Listing
August 2018
2 Reads

Angiocentric lymph proliferative disorder (lymphomatoid granulomatosis) in a person with newly-diagnosed HIV infection: a case report.

BMC Infect Dis 2018 05 8;18(1):210. Epub 2018 May 8.

Division of Infectious Diseases and Chronic Viral Illness Service, McGill University Health Centre, Royal Victoria Hospital, Glen Site, 1001 boulevard Decarie, Montreal, QC, H4A 3J1, Canada.

Background: Angiocentric lymph proliferative disorder (ALPD) is a granulomatous lymphoproliferative condition associated with various primary and secondary immunodeficiency states. ALPD is so rare that its prevalence has not been established. Typically affecting middle-aged adults, this condition is often found in the context of Epstein Bar Virus infection and consists of angiocentric and angioinvasive pulmonary infiltrates. Read More

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http://dx.doi.org/10.1186/s12879-018-3128-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941628PMC
May 2018
7 Reads

Primary pulmonary lymphoproliferative neoplasms.

Lung India 2018 May-Jun;35(3):220-230

Department of Internal Medicine, Divisions of Critical Care, Pulmonary and Sleep Medicine, UT Health- McGovern Medical School, Houston, Texas, USA.

Pulmonary lymphoproliferative neoplasms are rare lung tumors and account for <1% of all lung tumors. Among them, primary pulmonary lymphomas (PPL) constitute the majority, which include Non-Hodgkin's lymphoma (NHL) that comprise of mucosa-associated lymphoid tissue lymphoma, diffuse large B-cell lymphomas and other rare types of NHL and lymphomatoid granulomatosis. HL, which arises secondary to contiguous spread from the mediastinum, is the rarest type of PPL. Read More

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http://dx.doi.org/10.4103/lungindia.lungindia_381_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946555PMC
April 2018
7 Reads

Lymphomatoid granulomatosis: A case series from South India.

Indian J Pathol Microbiol 2018 Apr-Jun;61(2):228-232

Department of Pathology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.

Context: Lymphomatoid granulomatosis (LYG) is a rare B-lymphoproliferative disorder characterised by an angiocentric and angiodestructive pattern along with Epstein - Barr virus (EBV) association. It is one of the diagnostic challenges in lymphoma pathology. Deregulation of EBV immune surveillance is one of the narrated hypotheses in the literature. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_471_17DOI Listing
October 2018
230 Reads
0.642 Impact Factor

Primary lymphomatoid granulomatosis in the central nervous system: A report of three cases.

Neuropathology 2018 Apr 10. Epub 2018 Apr 10.

Department of Pathology, Seoul National University, College of Medicine, Seoul, Korea.

Lymphomatoid granulomatosis (LYG) is a rare lymphoproliferative disorder characterized by infiltration of Epstein-Barr virus (EBV)-positive large atypical B-cells in an angiocentric fashion in a mixed inflammatory background. The histologic spectrum of LYG ranges from reactive proliferation to diffuse large B-cell lymphoma according to the number of EBV+ B-cells. It is known that virtually all patients have pulmonary involvement, whereas primary LYG of the other organs has been rarely reported. Read More

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http://dx.doi.org/10.1111/neup.12467DOI Listing
April 2018
17 Reads

Oral Manifestation of Lymphomatoid Granulomatosis.

Head Neck Pathol 2018 Mar 14. Epub 2018 Mar 14.

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.

Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder driven by Esptein-Barr virus (EBV) that most commonly affects the lungs, although extra pulmonary sites like the central nervous system, skin, liver and kidney can also be involved. It is microscopically characterized by an angiocentric and angiodestructive growth pattern, predominantly composed by small T-cells, although a smaller population of atypical large B-cells is considered the true neoplastic component. Oral cavity involvement of LYG has rarely been described and the diagnosis of this neoplasm is very difficult. Read More

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http://dx.doi.org/10.1007/s12105-018-0910-xDOI Listing
March 2018
9 Reads

EBV-Positive Lymphoproliferations of B- T- and NK-Cell Derivation in Non-Immunocompromised Hosts.

Pathogens 2018 Mar 7;7(1). Epub 2018 Mar 7.

Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, University Hospital Tübingen, Eberhard-Karls-University, 72076 Tübingen, Germany.

The contribution of Epstein-Barr virus (EBV) to the development of specific types of benign lymphoproliferations and malignant lymphomas has been extensively studied since the discovery of the virus over the last 50 years. The importance and better understanding of the EBV-associated lymphoproliferative disorders (LPD) of B, T or natural killer (NK) cell type has resulted in the recognition of new entities like EBV+ mucocutaneous ulcer or the addition of chronic active EBV (CAEBV) infection in the revised 2016 World Health Organization (WHO) lymphoma classification. In this article, we review the definitions, morphology, pathogenesis, and evolving concepts of the various EBV-associated disorders including EBV+ diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), EBV+ mucocutaneous ulcer, DLBCL associated with chronic inflammation, fibrin-associated DLBCL, lymphomatoid granulomatosis, the EBV+ T and NK-cell LPD of childhood, aggressive NK leukaemia, extranodal NK/T-cell lymphoma, nasal type, and the new provisional entity of primary EBV+ nodal T- or NK-cell lymphoma. Read More

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http://dx.doi.org/10.3390/pathogens7010028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874754PMC
March 2018
7 Reads

Lymphomatoid Granulomatosis in a 14-Year-Old Boy with Trisomy 21 and History of B-Lymphoblastic Leukemia/Lymphoma.

Fetal Pediatr Pathol 2018 Feb 16;37(1):7-14. Epub 2018 Jan 16.

a Department of Pathology, University of Utah , Salt Lake City , Utah , United States.

Background: Lymphomatoid granulomatosis is a EBV-driven lymphoproliferative disorder that has been reported in association with immunodeficiency, but only exceptionally in patients with hematopoietic malignancy.

Case Report: A 14-year-old boy with trisomy-21 and a history of B-lymphoblastic leukemia/lymphoma (B-ALL) diagnosed 1.5 years prior, on maintenance chemotherapy, presented with fever and respiratory symptoms. Read More

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http://dx.doi.org/10.1080/15513815.2017.1379042DOI Listing
February 2018
18 Reads

A surgical case of methotrexate-associated lymphomatoid granuloma.

Gen Thorac Cardiovasc Surg 2018 Jul 19;66(7):435-438. Epub 2017 Dec 19.

Division of Thoracic Surgery, Department of Surgery, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa, 259-1193, Japan.

We reported a surgical case of methotrexate-associated lymphomatoid granuloma. A 69-year-old female had been treated with methotrexate for rheumatoid arthritis for 35 months. The patient underwent partial resection of the right upper pulmonary lobe for lung cancer when she was 67 years old. Read More

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http://dx.doi.org/10.1007/s11748-017-0871-0DOI Listing
July 2018
9 Reads

A Case of Hodgkin Lymphoma Mimicking Lymphomatoid Granulomatosis Diagnosed at Autopsy.

Lab Med 2017 Dec;49(1):80-86

Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cinncinati, OH.

Hodgkin lymphoma and lymphomatoid granulomatosis (LYG) are entities that contain a small number of large, variably Epstein-Barr virus (EBV)-positive neoplastic cells scattered within background non-neoplastic mixed inflammatory infiltrate. The 2 entities can typically be distinguished histologically by the angiocentric and angiodestructive pattern of lymphomatoid granulomatosis (LYG); also, they differ in overall prognosis. Herein, we report a case of Hodgkin lymphoma in a 64-year-old Caucasian woman, diagnosed at autopsy with unusual histologic features and aggressive clinical course that mimicked LYG. Read More

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http://dx.doi.org/10.1093/labmed/lmx065DOI Listing
December 2017
5 Reads

Unsuspected lymphomatoid granulomatosis in a patient with antisynthetase syndrome.

Cutis 2017 Oct;100(4):E22-E26

Department of Dermatology, Department of Pathology, University of Michigan, Ann Arbor, USA.

Clinical diagnosis of lymphomatoid granulomatosis (LYG) often is difficult, especially in patients with multiple comorbidities. We present a 60-year-old woman with worsening fatigue, night sweats, unintentional weight loss, and dyspnea of 2 weeks' duration. Her medical history was remarkable for recent radiation therapy for recurrent breast cancer and antisynthetase syndrome complicated by interstitial lung disease and controlled with azathioprine. Read More

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October 2017
8 Reads

Cancer Therapy-associated Lymphoproliferative Disorders: An Under-recognized Type of Immunodeficiency-associated Lymphoproliferative Disorder.

Am J Surg Pathol 2018 Jan;42(1):116-129

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX.

We describe the clinicopathologic features of 17 patients who had a hematologic malignancy of various types, were treated, and subsequently developed a lymphoproliferative disorder (LPD). There were 10 men and 7 women with a median age of 59 years (range, 36 to 83 y). The primary hematologic neoplasms included: 5 chronic lymphocytic leukemia/small lymphocytic lymphoma, 3 plasma cell myeloma, 2 acute monoblastic leukemia, and 1 case each of mixed-phenotype acute leukemia, chronic myeloid leukemia, splenic marginal zone lymphoma, follicular lymphoma, mantle cell lymphoma, T-cell prolymphocytic leukemia, and peripheral T-cell lymphoma. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000954DOI Listing
January 2018
6 Reads

Rare case of pulmonary lymphomatoid granulomatosis in conjunction with tuberculosis: A case report.

Medicine (Baltimore) 2017 Oct;96(42):e8323

aDivision of Infectious Diseases, Department of Internal Medicine bDepartment of Pathology cDivision of Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Rationale: Lymphomatoid granulomatosis is a very rare Epstein-Barr virus-driven lymphoproliferative disease. This disease has high mortality owing to its low incidence in conjunction with nonspecific presentations, which contribute to delays in diagnosis.

Patient: An 87-year-old male had a week-long history of intermittent fever and general weakness. Read More

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http://dx.doi.org/10.1097/MD.0000000000008323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662409PMC
October 2017
24 Reads

Pulmonary lymphomatoid granulomatosis diagnosed by image-guided core needle biopsy.

Asian Cardiovasc Thorac Ann 2018 Jan 11;26(1):70-71. Epub 2017 Oct 11.

3 Department of Pathology, Ramón y Cajal University Hospital, Madrid, Spain.

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http://dx.doi.org/10.1177/0218492317738383DOI Listing
January 2018
4 Reads

Epstein-Barr virus-positive diffuse large B-cell lymphoma.

Proc (Bayl Univ Med Cent) 2017 Oct;30(4):443-444

Departments of Pathology (Murthy, Hitchcock, Krause) and Internal Medicine (Endicott-Yazdani, Watson), Baylor University Medical Center at Dallas, Texas.

While the World Health Organization included Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) as a provisional entity of a lymphoma occurring in older individuals without any known immunodeficiency in 2008, it has since been recognized that this entity may occur in younger individuals. As a result, the 2016 revision has substituted the modifier "elderly" with "not otherwise specified" (NOS). The NOS highlights that there are more specific entities with neoplastic EBV-positive large B cells such as lymphomatoid granulomatosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595389PMC
October 2017
5 Reads

Lymphomatoid Granulomatosis: A Rare Tumor with Poor Prognosis.

Arch Bronconeumol 2018 Feb 31;54(2):108-109. Epub 2017 Aug 31.

Servicio de Anatomía Patológica, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Tenerife, España.

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http://dx.doi.org/10.1016/j.arbres.2017.07.008DOI Listing
February 2018
12 Reads

The Complete Remission of Acquired Immunodeficiency Syndrome-associated Isolated Central Nervous System Lymphomatoid Granulomatosis: A Case Report and Review of the Literature.

Intern Med 2017 Sep 21;56(18):2497-2501. Epub 2017 Aug 21.

Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.

A 49-year-old man presented with gradually progressive aphasia one month after being diagnosed with acquired immunodeficiency syndrome (AIDS). Brain magnetic resonance imaging showed multiple brain lesions with punctate and linear enhancement. A polymerase chain reaction detected Epstein-Barr virus (EBV) in the patient's cerebrospinal fluid. Read More

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http://dx.doi.org/10.2169/internalmedicine.8776-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643181PMC
September 2017
16 Reads

A Rare Case of Pulmonary Lymphomatoid Granulomatosis.

S D Med 2017 Jan;70(1):22-24

Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD.

In this report, we discuss an unusual case of pulmonary lymphomatoid granulomatosis (LYG), a rare form of angiocentric and angiodestructive lymphoproliferative disorder. This disease is thought to be caused by Epstein-Barr virus-induced lymphoproliferation. A 39-year-old male with no signi ficant past medical history presented with flu-like symptoms. Read More

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January 2017
64 Reads

[Hot lung nodules on PET-CT].

Ann Pathol 2017 Aug 25;37(4):327-331. Epub 2017 Jul 25.

Service d'anatomie et cytologie pathologiques, hôpital Bichat, 46, rue Henri-Huchard, 75877 Paris cedex 18, France.

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http://dx.doi.org/10.1016/j.annpat.2017.06.001DOI Listing
August 2017
6 Reads

IgG4-Related disease simulating paraneoplastic syndrome: Role of FDG PET/CT imaging.

Indian J Radiol Imaging 2017 Apr-Jun;27(2):249-253

Department of Nuclear Medicine and PET-CT, P.D. Hinduja National Hospital and MRC, Mumbai, Maharashtra, India.

Immunoglobulin G4 (IgG4)-related systemic disease (IgG4-RSD) is a new systemic entity associated with autoimmune pancreatitis (AIP). Other organ involvements take the form of sclerosing cholangitis, sclerosing cholecystitis, sclerosing sialadenitis, retroperitoneal fibrosis, and interstitial nephritis. Recently, lung diseases related to IgG4 have been described to occur with or without other organ involvement. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_135_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510325PMC
July 2017
12 Reads

Lymphoproliferative Disorders of the Lung.

Respiration 2017 14;94(2):157-175. Epub 2017 Jun 14.

Service de Pneumologie A, Centre de compétences maladies pulmonaires rares, AP-HP, Hôpital Bichat, Paris, France.

This review aims to describe some of the most frequent lymphoproliferative disorders arising from the lung: pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma, lymphomatoid granulomatosis (LG), multicentric Castleman disease (MCD), primary effusion lymphoma (PEL), and nodular lymphoid hyperplasia (NLH). Primary pulmonary lymphoma is defined as a clonal lymphoproliferative disorder affecting one or both lungs, without extrapulmonary involvement 3 months after diagnosis, and includes pulmonary MALT lymphoma and LG. MALT lymphoma is the most common pulmonary lymphoma. Read More

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http://dx.doi.org/10.1159/000477740DOI Listing
May 2018
28 Reads

Epstein-Barr Virus-associated Lymphoproliferative Disorders in the Skin.

Authors:
John R Goodlad

Surg Pathol Clin 2017 Jun 18;10(2):429-453. Epub 2017 Mar 18.

Haematological Malignancy Diagnostic Services (HMDS), Level 3, Bexley Wing, St James's University Hospital, Leeds LS9 7TF, UK. Electronic address:

Epstein-Barr virus (EBV)-associated lymphoproliferations involving the skin are a rare but important group of diseases with a broad spectrum of behavior, ranging from self-limiting spontaneously resolving disorders to highly aggressive malignancies. They may be of B, T, or natural killer (NK) cell type and include EBV-positive mucocutaneous ulcer, lymphomatoid granulomatosis, EBV-positive diffuse large B-cell lymphoma, hydroa vacciniforme-like lymphoproliferative disorder, and extranodal NK/T-cell lymphoma of nasal type. Recognition and distinction of these entities is important in view of their differing prognoses and treatments. Read More

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http://dx.doi.org/10.1016/j.path.2017.01.001DOI Listing
June 2017
29 Reads

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presented as T-Lymphoid Hyperplasia Involving the Central Nervous System.

Cureus 2017 Mar 26;9(3):e1119. Epub 2017 Mar 26.

Department of Neuropathology, Tokyo Metropolitan Neurological Hospital.

We herein report a case of T-cell/histiocyte-rich large B-cell lymphoma which initially presented as a self-limiting T-lymphoproliferative disorder involving multiple extranodal and extrapulmonary organs, such as the salivary gland, the liver, and the central nervous system. Repeated biopsies only revealed polyclonal T-lymphocytosis without the presence of atypical B-cells. Angiocentric cellular infiltration was absent, thus ruling out lymphomatoid granulomatosis. Read More

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http://dx.doi.org/10.7759/cureus.1119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406172PMC
March 2017
17 Reads

DOCK 8 Deficiency, EBV+ Lymphomatoid Granulomatosis, and Intrafamilial Variation in Presentation.

Front Pediatr 2017 28;5:38. Epub 2017 Feb 28.

NIAID, NIH , Bethesda, MD , USA.

Dedicator of cytokinesis 8 (DOCK8) deficiency is an autosomal recessive, combined immunodeficiency within the spectrum of hyper-IgE syndromes. Epstein-Barr virus-positive lymphomatoid granulomatosis (LYG) (EBV + LYG) is a rare diagnosis and a previously unreported presentation of DOCK8 deficiency. A 10-year-old girl was initially evaluated for mild eczema and recurrent sinopulmonary infections. Read More

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http://dx.doi.org/10.3389/fped.2017.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328973PMC
February 2017
8 Reads

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A lymphocytic reactive response of the central nervous system? A case report.

J Neuroimmunol 2017 04 26;305:68-71. Epub 2017 Jan 26.

The PLA General Hospital, Department of Neurology, PR China. Electronic address:

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroid (CLIPPERS) was first described in 2010. The characteristic clinical picture, radiological distribution and steroid response have been well-described in previous reports. However, the underlying pathogenesis and nosological position of CLIPPERS in the CNS require further investigation for the primary CNS lymphoma have been identified by autopsy subsequently. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2017.01.014DOI Listing
April 2017
8 Reads

Cutaneous human immunodeficiency virus (HIV)-associated lymphomatoid granulomatosis: complete regression following antiretroviral therapy.

Int J Dermatol 2017 May 10;56(5):e100-e102. Epub 2017 Feb 10.

Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

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http://doi.wiley.com/10.1111/ijd.13551
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http://dx.doi.org/10.1111/ijd.13551DOI Listing
May 2017
9 Reads

Lymphomatoid granulomatosis with pulmonary and gastrointestinal involvement.

BMJ Case Rep 2017 Feb 6;2017. Epub 2017 Feb 6.

Department of Pulmonology, Sint Franciscus Vlietland Groep, Rotterdam, The Netherlands.

We present a rare case of grade II lymphomatoid granulomatosis (LYG) with pulmonary and gastrointestinal involvement. LYG is considered an Epstein-Barr virus-driven lymphoproliferative disorder that often presents with multiple nodular lesions in the lungs and sometimes involvement of skin and the central nervous system. Although the aetiology is unknown, it is associated with the use of immunosuppressives. Read More

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http://dx.doi.org/10.1136/bcr-2016-218369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293970PMC
February 2017
4 Reads

[The understanding of Epstein-Barr virus associated lymphoproliferative disorder].

Zhonghua Bing Li Xue Za Zhi 2016 Dec;45(12):817-821

Department of Pathology, Beijing Friendship Hospital Capital Medical University, Beijing 100050, China.

In recent years, there are increasing articles concerning Epstein-Barr virus associated lymphoproliferative disorder (EBV+ LPD), and the name of EBV+ LPD is used widely. However, the meaning of EBV+ LPD used is not the same, which triggered confusion of the understanding and obstacles of the communication. In order to solve this problem. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2016.12.001DOI Listing
December 2016
6 Reads

Lymphomatoid granulomatosis initially presenting as ulcerated subcutaneous and muscle lesions without pulmonary involvement.

J Dermatol 2017 May 18;44(5):e107-e108. Epub 2016 Dec 18.

Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

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http://dx.doi.org/10.1111/1346-8138.13712DOI Listing
May 2017
11 Reads

Pulmonary Lymphomatoid Granulomatosis- a Case Report with Review of Literature.

Indian J Surg Oncol 2016 Dec 29;7(4):484-487. Epub 2016 Apr 29.

Department of histopathology, Sir Gangaram Hospital, Ist floor, SSRB Block. Rajender Nagar, New Delhi, India.

Lymphomatoid granulomatosis is a rare, Epstein Barr Virus (EBV)-associated systemic angiodestructive disorder that may progress to a diffuse large B cell lymphoma. Pulmonary involvement occurs in over 90 % cases followed by kidney, skin and brain. WHO classifies lymphomatoid granulomatosis under the generic heading of B cell proliferations of uncertain malignant potential. Read More

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http://dx.doi.org/10.1007/s13193-016-0525-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097759PMC
December 2016
8 Reads

Lymphomatoid Granulomatosis: Two Different Phenotypes of Computed Tomography Findings.

J Thorac Imaging 2016 Nov;31(6):W80-W82

Departments of *Clinical Radiology †Molecular Imaging and Diagnosis ∥Surgery and Science ¶Anatomic Pathology ‡Health Sciences §Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1097/RTI.0000000000000243DOI Listing
November 2016
8 Reads

Lymphomas-Part 2.

Neuroimaging Clin N Am 2016 Nov;26(4):537-565

Division of Neuroradiology, Department of Radiology, University of North Carolina, School of Medicine, Room 3326, Old Infirmary Building, Manning Drive, Chapel Hill, NC 27599-7510, USA.

There are 2 types of central nervous system lymphoma: primary and secondary. Both have variable imaging features making them diagnostic challenges. Furthermore, a patient's immune status significantly alters the imaging findings. Read More

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http://dx.doi.org/10.1016/j.nic.2016.06.005DOI Listing
November 2016
7 Reads

Lymphomatoid granulomatosis associated with azathioprine use for immune-mediated neuropathy.

BMJ Case Rep 2016 Sep 26;2016. Epub 2016 Sep 26.

VA Puget Sound Health Care System, Seattle, Washington, USA Division of Hematology, University of Washington School of Medicine, Seattle, Washington, USA.

Lymphomatoid granulomatosis (LG) is a rare Epstein-Barr virus-driven lymphoproliferative disorder that generally arises in immunosuppressed patients and which can be life-threatening. Here we describe the development of pulmonary LG in a patient on long-term azathioprine for immune-mediated neuropathy. Although azathioprine carries a boxed warning for malignancy, its association specifically with LG, an otherwise rare entity, is poorly recognised. Read More

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http://dx.doi.org/10.1136/bcr-2016-216930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051443PMC
September 2016
24 Reads

[CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids)].

Authors:
Shinichi Kan

Brain Nerve 2016 Sep;68(9):1069-1080

Department of Radiology, Sagamihara Chuo Hospital.

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) has been recently identified as an inflammatory central nervous system (CNS) disorder. Punctate and curvilinear gadolinium enhancement (peppering) the pons is a characteristic magnetic resonance imaging (MRI) feature of CLIPPERS. Pathogenesis of this disorder remains unknown. Read More

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http://dx.doi.org/10.11477/mf.1416200554DOI Listing
September 2016
2 Reads