934 results match your criteria Lymphomatoid Granulomatosis


Mimickers of pulmonary lymphoma.

Semin Diagn Pathol 2020 Jun 9. Epub 2020 Jun 9.

Department of Pathology, City of Hope, Duarte, CA, USA. Electronic address:

There are multiple entities that involve the lung that have radiographic, clinical, and morphologic overlaps with pulmonary lymphoma. In this review, we will discuss these entities in detail and provide relevant updates. Read More

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http://dx.doi.org/10.1053/j.semdp.2020.05.002DOI Listing

Extranodal NK/T cell lymphoma and lymphomatoid granulomatosis in a patient with chronic lymphocytic leukaemia: Case report for a new perspective on Richter syndrome.

Medicine (Baltimore) 2020 May;99(19):e20106

Department of Pathology.

Rationale: Richter syndrome (RS) defines the transformation of chronic lymphocytic leukemia (CLL) into a more aggressive lymphoma. Although the term RS is most often reserved for transformation of CLL into diffuse large B-cell lymphoma (DLBCL), and less frequently Hodgkin lymphoma , the list of cases with more variable presentations in the literature is growing.

Patient Concerns: A 71-year-old Caucasian man initially consulted an otolaryngologist for a 1-year history of nasal congestion. Read More

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http://dx.doi.org/10.1097/MD.0000000000020106DOI Listing
May 2020
5.723 Impact Factor

Pulmonary Recurrence of Lymphomatoid Granulomatosis Diagnosed on F-18 FDG PET/CT.

Indian J Nucl Med 2020 Apr-Jun;35(2):167-169. Epub 2020 Mar 12.

Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Lymphomatoid granulomatosis (LYG) is a rare, extranodal B-cell lymphoproliferative disorder. The disease commonly presents with nonspecific symptoms and imaging features, making the diagnosis and therapeutic response assessment difficult. While histopathology is the mainstay of diagnosis, different imaging modalities such as computed tomography (CT), magnetic resonance imaging, or F18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) can help in identifying the different organs involved. Read More

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http://dx.doi.org/10.4103/ijnm.IJNM_174_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182321PMC

Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder.

Blood 2020 Apr;135(16):1344-1352

Lymphoid Malignancies Branch, Center for Cancer Research and.

Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus (EBV)-driven B-cell lymphoproliferative disease (LPD). This disease is hypothesized to result from defective immune surveillance of EBV, with most patients showing evidence of immune dysfunction, despite no known primary immunodeficiency. Pathologically, LYG is graded by the number and density of EBV+ atypical B cells, and other characteristic findings include an angioinvasive/angiodestructive reactive T-cell infiltrate and various degrees of necrosis. Read More

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http://dx.doi.org/10.1182/blood.2019000933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162687PMC

Pulmonary Lymphomatoid Granulomatosis With Hemophagocytic Lymphohistiocytosis as the Initial Manifestation.

Front Oncol 2020 29;10:34. Epub 2020 Jan 29.

Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Lymphomatoid granulomatosis (LYG) is an extremely rare angio-centric and angio-destructive B-cell lymphoproliferative disease. Driven by Epstein-Barr virus (EBV), LYG predominantly involves the bilateral lungs. Commonly presenting as multiple nodules in the lung, pulmonary LYG can masquerade as various infectious diseases, vasculitis, lung cancer, or other metastatic neoplasm. Read More

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http://dx.doi.org/10.3389/fonc.2020.00034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000656PMC
January 2020

[A Case of Primary Central Nervous System Lymphomatoid Granulomatosis that was Completely Ameliorated by Corticosteroid Treatment].

Brain Nerve 2020 Feb;72(2):159-165

Department of Neurosurgery, Kindai University School of Medicine.

Lymphomatoid granulomatosis (LYG) is an angiocentric, angiodestructive lymphoreticular proliferative disease that usually affects the lungs but it has been speculated to also effect the central nervous system (CNS). However, unique primary LYG of the CNS has rarely been reported in the literature. Herein, we describe a clinical case of a 37-year-old female patient with grade 1 primary CNS-LYG having a good prognosis owing to corticosteroid treatment. Read More

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http://dx.doi.org/10.11477/mf.1416201496DOI Listing
February 2020

A 4-Year-Old Boy With Prolonged Cough and Fever.

J Pediatric Infect Dis Soc 2020 Feb;9(1):92-95

Division of Infectious Diseases, Department of Pediatrics, Stony Brook Children's Hospital, Stony Brook, New York, USA.

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http://dx.doi.org/10.1093/jpids/piaa005DOI Listing
February 2020

Isolated lymphomatoid granulomatosis of the central nervous system: A case report and literature review.

Neuropathology 2019 Dec 20;39(6):479-488. Epub 2019 Nov 20.

Department of Neurology, Chinese PLA General Hospital, Beijing, China.

Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoproliferative disease which can involve multiple organs of the body and is most common in the lungs. Its pathological features are proliferation of large atypical B-cells related to Epstein-Barr virus, T-cell infiltration and tissue necrosis. This disease is rare, and LYG which uniquely involves the central nervous system (CNS) is extremely rare. Read More

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http://dx.doi.org/10.1111/neup.12605DOI Listing
December 2019

Multiple Neurologic Deficits and Cognitive Decline in a Young Woman.

Ann Indian Acad Neurol 2019 Oct-Dec;22(4):506-512. Epub 2019 Oct 25.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

We present the clinicopathologic conference of a 34-year-old lady with history of facial palsy 14 years ago who developed new deficits of mononeuritis multiplex, maculopapular rash, pancytopenia, splenomegaly, lung involvement and cognitive decline rapidly over three years. Investigations revealed pancytopenia, reversal of albumin globulin ratio, mediastinal adenopathy, ANA positivity, low C3 levels with the CSF being inflammatory and MRI showing extensive hemorrhagic lesions with mass effect. She had a rapidly progressive fatal course over three years with the disease being undiagnosed. Read More

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http://dx.doi.org/10.4103/aian.AIAN_293_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839316PMC
October 2019
3 Reads

Diffuse large B-cell lymphoma variants: an update.

Pathology 2020 Jan 15;52(1):53-67. Epub 2019 Nov 15.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma, representing approximately one-third of all cases worldwide. In the World Health Organization (WHO) classification of lymphomas, most cases of DLBCL are designated as not otherwise specified (NOS). About 20% of cases, however, are designated as specific variants of DLBCL. Read More

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http://dx.doi.org/10.1016/j.pathol.2019.08.013DOI Listing
January 2020

Traumatic Ulcerative Granuloma with Stromal Eosinophilia: CD30 analysis and clonality for T cell receptor gene re-arrangement.

Acta Histochem 2019 Nov 29;121(8):151450. Epub 2019 Oct 29.

Institute of Pathology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; Department of Oral Pathology and Oral Medicine, Goldschleger School of Dental Medicine, Tel-Aviv University, Tel Aviv, Israel; Sourasky Faculty of Medicine, Tel-Aviv University, Israel. Electronic address:

Introduction: Traumatic Ulcerative Granuloma with Stromal Eosinophilia (TUGSE) is a rare oral ulcerated lesion of uncertain etiology, showing eosinophil-rich granulation tissue, with occasional large atypical CD30 positive mononuclear cells. It had been suggested that it may represent an oral counterpart of cutaneous lymphomatoid papulosis, with a potential to evolve into CD30 + T cell lymphoma OBJECTIVES: To compare TUGSE and non-specific oral ulcers (NSU) clinically, histopathologically and by clonality analysis for T-cell receptor re-arrangement, aiming to determine whether TGUSE with atypical cells is a lymphomatous premalignant condition, and whether therapeutic approach should be radical or conservative.

Materials And Methods: Retrospective archival analysis included 17 TUGSE and 8 NSU cases. Read More

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http://dx.doi.org/10.1016/j.acthis.2019.151450DOI Listing
November 2019
1 Read

Magnesium Restores Activity to Peripheral Blood Cells in a Patient With Functionally Impaired Interleukin-2-Inducible T Cell Kinase.

Front Immunol 2019 27;10:2000. Epub 2019 Aug 27.

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

Interleukin-2-inducible T cell kinase (ITK) is critical for T cell signaling and cytotoxicity, and control of Epstein-Barr virus (EBV). We identified a patient with a novel homozygous missense mutation (D540N) in a highly conserved residue in the kinase domain of ITK who presented with EBV-positive lymphomatoid granulomatosis. She was treated with interferon and chemotherapy and her disease went into remission; however, she has persistent elevation of EBV DNA in the blood, low CD4 T cells, low NK cells, and nearly absent iNKT cells. Read More

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http://dx.doi.org/10.3389/fimmu.2019.02000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718476PMC
August 2019
8 Reads

An atypical case of a pulmonary mass in an immunocompromised patient.

Acta Clin Belg 2019 Aug 17:1-5. Epub 2019 Aug 17.

Department of Pulmonology, University Hospitals Leuven , Leuven , Belgium.

Pulmonary lymphomatoid granulomatosis (PLG) is a rare angiocentric and angiodestructive EBV-associated lymphoproliferative disorder which almost always affects the lungs. PLG is more commonly diagnosed in patients with immunodeficiency and is associated with Epstein-Barr virus (EBV). 'Drug induced PLG' or 'iatrogenic immunodeficiency-associated lymphoproliferative disorder' is a special form of PLG described in patient with inflammatory bowel diseases treated with Azathioprine. Read More

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https://www.tandfonline.com/doi/full/10.1080/17843286.2019.1
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http://dx.doi.org/10.1080/17843286.2019.1655232DOI Listing
August 2019
3 Reads

Case-based discussion: a case of misdiagnosis of primary lung malignancy.

Thorax 2019 10 5;74(10):1003-1005. Epub 2019 Aug 5.

Lancashire Chest Centre, Royal Preston Hospital, Preston, UK

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http://dx.doi.org/10.1136/thoraxjnl-2019-213145DOI Listing
October 2019
1 Read

EBV-Associated Lymphoproliferative Disorders: Update in Classification.

Surg Pathol Clin 2019 Sep;12(3):745-770

Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, 101 The City Drive, Orange, CA 92868, USA; NeoGenomics Laboratories, 31 Columbia, Aliso Viejo, CA 92656, USA. Electronic address:

Although about 90% of the world's population is infected by EBV only a small subset of the related infections result in neoplastic transformation. EBV is a versatile oncogenic agent involved in a multitude of hematopoietic, epithelial, and mesenchymal neoplasms, but the precise role of EBV in the pathogenesis of many of the associated lymphoid/histiocytic proliferations remains hypothetical or not completely understood. Additional studies and use of evolving technologies such as high-throughput next-generation sequencing may help address this knowledge gap and may lead to enhanced diagnostic assessment and the development of potential therapeutic interventions. Read More

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http://dx.doi.org/10.1016/j.path.2019.03.002DOI Listing
September 2019
3 Reads

Simultaneous Presentation of Lymphomatoid Granulomatosis and Multiple myeloma in an Immunodeficient Patient with Rheumatoid Arthritis.

Intern Med 2019 Oct 27;58(19):2845-2849. Epub 2019 Jun 27.

Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Japan.

A 75-year-old Japanese woman with a 20-year history of rheumatoid arthritis presented with symptomatic bilateral pleural effusion and lung and brain tumors. She had received methotrexate for five years and tacrolimus for one year. A brain biopsy specimen showed the pathological features of lymphoproliferative disease, but a bone marrow biopsy showed proliferation of plasma cells. Read More

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http://dx.doi.org/10.2169/internalmedicine.2811-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815885PMC
October 2019
10 Reads

An update on IgG4-related lung disease.

Eur J Intern Med 2019 Aug 19;66:18-24. Epub 2019 Jun 19.

Division of Pulmonary and Critical Care, Department of Medicine, University of Miami, Miami, FL, USA. Electronic address:

IgG4-related disease (IgG4-RD) is an autoimmune disorder characterized by substantial infiltration of plasma cells with IgG4 in target organs. Lung manifestations predominantly present as inflammatory pseudotumor, interstitial pneumonitis, organizing pneumonia, and lymphomatoid granulomatosis. There is no specific diagnostic test for IgG4-related lung disease (IgG4-RLD), and excluding diseases that mimic IgG4-RLD is important. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.06.010DOI Listing
August 2019
19 Reads

A Case of Methotrexate-Associated Lymphoproliferative Disorder (Lymphomatoid Granulomatosis) of the Skin.

Am J Dermatopathol 2019 Jun;41(6):448-452

Departments of Diagnostic Pathology, and.

Iatrogenic lymphoproliferative disorder (LPD) can develop in patients treated with immunosuppressive drugs for autoimmune or other inflammatory diseases. Here, we report a case of lymphomatoid granulomatosis of the skin that occurred as a methotrexate (MTX)-associated LPD. We also review the relevant literature. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001301DOI Listing
June 2019
8 Reads

CLIPPERS and its mimics: evaluation of new criteria for the diagnosis of CLIPPERS.

J Neurol Neurosurg Psychiatry 2019 09 9;90(9):1027-1038. Epub 2019 May 9.

Department of Neurology, University Hospital of Montpellier, Montpellier, France.

Objective: To evaluate the accuracy of the recently proposed diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS).

Methods: We enrolled 42 patients with hindbrain punctate and/or linear enhancements (<3 mm in diameter) and tested the CLIPPERS criteria.

Results: After a median follow-up of 50 months (IQR 25-82), 13 out of 42 patients were CLIPPERS-mimics: systemic and central nervous system lymphomas (n=7), primary central nervous system angiitis (n=4) and autoimmune gliopathies (n=2). Read More

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http://dx.doi.org/10.1136/jnnp-2018-318957DOI Listing
September 2019
17 Reads

A rare lymphoproliferative disorder associated with immunomodulating therapy in Crohn's disease.

Rev Esp Enferm Dig 2019 06;111(6):491

Digestivo, Hospital Universitario de Cabueñes, España.

Lymphomatoid granulomatosis is a rare lymphoproliferative disorder associated with immunosuppressive therapy in inflammatory bowel disease. We present the case of a patient with Crohn's disease and treated azathioprine that develops lymphomatoid granulomatosis, as well as its diagnostic process and the chosen treatment. Lymphomatoid granulomatosis is a serious disease barely described and whose suspicion is essential for its prognosis. Read More

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http://dx.doi.org/10.17235/reed.2019.5990/2018DOI Listing
June 2019
5 Reads

A 53-Year-Old Man Presenting With Diplopia and Cavitary Lung Nodules.

Chest 2019 04;155(4):e107-e112

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.

Case Presentation: A 53-year-old Chinese man presented with 1 week of worsening diplopia and left-sided facial droop. His symptoms developed during a readmission for elective drainage and curettage of a perianal abscess that recurred despite drainage 2 weeks before. He denied having other neurologic symptoms, and did not report any cough, sputum production, night sweats, or fever. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692183260
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http://dx.doi.org/10.1016/j.chest.2018.10.021DOI Listing
April 2019
26 Reads
7.483 Impact Factor

Primary lymphomatoid granulomatosis in the central nervous system: A report of three cases.

Neuropathology 2019 04 3;39(2):168-169. Epub 2019 Mar 3.

Department of Neurology, Centre Hospitalier de Saint-Denis, Hôpital Delafontaine, Saint-Denis, France.

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http://dx.doi.org/10.1111/neup.12546DOI Listing
April 2019
9 Reads

The Role and Pitfall of F18-FDG PET/CT in Surveillance of High Grade Pulmonary Lymphomatoid Granulomatosis.

Curr Probl Diagn Radiol 2019 Feb 10. Epub 2019 Feb 10.

Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ.

Lymphomatoid granulomatosis (LYG) is an uncommon angiocentric and angiodestructive T-cell rich, Epstein-Barr virus (EBV) positive B-cell multisystem lymphoproliferative disorder, predominately affecting the lungs. Since both clinical presentation and radiographic imaging findings, including X-ray and computed tomographic (CT), are nonspecific, the ultimate diagnosis of LYG relies on lung tissue sample diagnosis with its WHO grading based on the degree of cytologic atypia, necrosis and density of EBV positive B-cells. In addition, its histopathologic grading is correlated with clinical manifestation with high grade LYG mimicking aggressive B-cell lymphoma. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2019.02.002DOI Listing
February 2019
7 Reads

Lymphomatoid Granulomatosis in a Patient with Chronic Lymphocytic Leukemia and Rapidly Progressing Peribronchovascular Pulmonary Infiltrates.

Case Rep Pulmonol 2019 21;2019:9870494. Epub 2019 Jan 21.

Wayne State University School of Medicine, Lymphoma Research Laboratory, 540 E Canfield Room No. 8829, Detroit, MI 48202, USA.

Lymphomatoid granulomatosis (LG) is an EBV-associated angiodestructive lymphoproliferative disease with multiorgan involvement that predominantly affects the lungs. We present a case of a 72-year-old man with a history of chronic lymphocytic leukemia who presented with upper respiratory symptoms and multiple erythematous skin papules. Chest CT showed ill-defined, irregular solid pulmonary nodules with peripheral ground-glass opacities in a peribronchovascular distribution. Read More

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http://dx.doi.org/10.1155/2019/9870494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363242PMC
January 2019
7 Reads

Endobronchial Manifestation of Methotrexate-induced Lymphoproliferative Disorder.

Intern Med 2019 Jun 1;58(11):1597-1603. Epub 2019 Feb 1.

Department of Respiratory Medicine, Japanese Red Cross Wakayama Medical Center, Japan.

Lymphoproliferative disorders can occur in patients with autoimmune disorders who undergo long-term methotrexate therapy (MTX-LPD). Although the manifestations of MTX-LPD are diverse, little attention is paid to endobronchial involvement. We herein describe two patients with MTX-LPD who presented with parenchymal pulmonary tumors and endobronchial involvement of LPD; one had lymphomatoid gramulomatosis and the other LPD. Read More

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http://dx.doi.org/10.2169/internalmedicine.2109-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599933PMC
June 2019
4 Reads

Lymphomatoid granulomatosis: a rare lymphoproliferative disease in the pediatric age.

Radiologia 2019 Mar - Apr;61(2):179-180. Epub 2018 Oct 15.

Servicio de Radiodiagnóstico, Hospital Universitario Virgen del Rocío, Sevilla, España.

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https://linkinghub.elsevier.com/retrieve/pii/S00338338183016
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http://dx.doi.org/10.1016/j.rx.2018.09.001DOI Listing
November 2019
8 Reads

Case 259: Primary Central Nervous System Lymphomatoid Granulomatosis Mimicking Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS).

Radiology 2018 11;289(2):572-577

From the Bejing-TJ Center for Neuroinflammation, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (D.T.); Department of Neurology, Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, China (X.Z., R.X., P.Z.); and Department of Neurology, Guizhou Provincial People's Hospital, Medical School of Guizhou University, Zhongshan East Road 83, Guiyang 550002, China (Y.Y.).

History In November 2012, a previously healthy 31-year-old woman was admitted to our hospital with a 2-month history of right-sided numbness, diplopia, and intermittent nausea and dizziness. She did not have a history of fever, weight loss, headache, photophobia, seizure, or extremity weakness. Physical examination revealed left abduction limitation and right-sided hypoesthesia. Read More

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http://pubs.rsna.org/doi/10.1148/radiol.2018161475
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http://dx.doi.org/10.1148/radiol.2018161475DOI Listing
November 2018
11 Reads

Pediatric oral Epstein-Barr virus associated self-remitting CD30+ lymphoproliferative disorder: A distinct entity.

Ann Diagn Pathol 2018 Dec 12;37:57-61. Epub 2018 Sep 12.

Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address:

Epstein-Barr virus (EBV) has a well-known association with lymphoproliferative disorders of B and T cell origin. EBV-related B cell lymphoproliferative disorders include Hodgkin and Burkitt lymphomas, lymphomatoid granulomatosis, EBV positive diffuse large cell B cell lymphoma of the elderly, as well as B cell lymphomas associated with solid organ transplantation and methotrexate use. EBV-related T cell disorders are primarily represented by NK/T- cell lymphoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183023
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http://dx.doi.org/10.1016/j.anndiagpath.2018.08.004DOI Listing
December 2018
21 Reads

Lymphomatoid granulomatosis mimicking cancer and sarcoidosis.

Ann Hematol 2019 May 5;98(5):1309-1311. Epub 2018 Oct 5.

Institute of Pathology and Molecular Pathology, University Hospital Zurich, Rämistrasse 100, 8091, Zürich, Switzerland.

Two cases of misdiagnoses of lymphomatoid granulomatosis are discussed here. Lymphomatoid granulomatosis is an Epstein-Barr virus-associated lymphoproliferative disorder with aggressive behavior. Due to its rarity and many presentations, delay in diagnosis and treatment is common. Read More

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http://link.springer.com/10.1007/s00277-018-3505-4
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http://dx.doi.org/10.1007/s00277-018-3505-4DOI Listing
May 2019
5 Reads

Oral ulceration: an unusual manifestation of lymphomatoid granulomatosis.

Ann Hematol 2019 May 3;98(5):1305-1307. Epub 2018 Oct 3.

Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501, Japan.

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http://link.springer.com/10.1007/s00277-018-3506-3
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http://dx.doi.org/10.1007/s00277-018-3506-3DOI Listing
May 2019
27 Reads

Necrotic Plaque on the Distal Nose With Diffuse Crateriform Nodules.

JAMA Dermatol 2019 Jan;155(1):113-114

Department of Dermatology, University of Virginia, Charlottesville.

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http://dx.doi.org/10.1001/jamadermatol.2018.2552DOI Listing
January 2019
1 Read

Unique case of trigeminal neuralgia due to Epstein-Barr-virus-associated B-cell lymphomatoid granulomatosis of the Meckel's cave and cavernous sinus: Important clinical and therapeutic implications.

Surg Neurol Int 2018 26;9:148. Epub 2018 Jul 26.

Department of Neurosurgery, Mainz University Hospital, Langenbeckstraße 1, 55131 Mainz, Germany.

Background: Trigeminal neuralgia (TN) represents one of the most disabling pain syndromes. Several diseases have been described as etiological triggers of TN, vascular compression of the trigeminal nerve being the most frequent cause. Here, we describe for the first time a rare case of TN caused by an infiltration of an isolated Epstein-Barr virus (EBV) B-cell lymphomatoid granulomatosis (LYG) mass into the Meckel's cave and cavernous sinus. Read More

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http://dx.doi.org/10.4103/sni.sni_12_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080144PMC
July 2018
9 Reads

Cutaneous lymphomatoid granulomatosis with long-term absence of lung involvement.

J Dermatol 2019 Feb 16;46(2):e69-e70. Epub 2018 Jul 16.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

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http://dx.doi.org/10.1111/1346-8138.14548DOI Listing
February 2019
11 Reads

Pitfall of F-FDG PET/CT in Characterization of Relapsed Multisystem Lymphomatoid Granulomatosis.

J Nucl Med Technol 2018 Dec 8;46(4):396-397. Epub 2018 Jun 8.

Department of Radiology, Mayo Clinic Arizona, Scottsdale, Arizona

We present serial F-FDG PET/CT findings in a case of grade 3 pulmonary lymphomatoid granulomatosis positive for the Epstein-Barr virus. The patient experienced a transient complete response to R-CHOP chemotherapy and subsequent multisystem recurrence, predominately involving the subcutaneous region of the torso on F-FDG PET/CT. Biopsy of the most hypermetabolic subcutaneous lesion demonstrated grade 1 cutaneous lymphomatoid granulomatosis negative for the Epstein-Barr virus. Read More

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http://dx.doi.org/10.2967/jnmt.118.212274DOI Listing
December 2018
11 Reads

The Spontaneous Regression of Grade 3 Methotrexate-related Lymphomatoid Granulomatosis: A Case Report and Literature Review.

Intern Med 2018 Nov 6;57(21):3163-3167. Epub 2018 Jun 6.

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan.

Lymphomatoid granulomatosis (LYG) is a rare lung disorder diagnosed by radiological imaging of multiple pulmonary nodules and occasionally induced by methotrexate (MTX) use. To date, the treatment of LYG has not been standardized. We herein report the case of a patient with grade 3 MTX-related LYG who presented a bulky lung mass. Read More

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http://dx.doi.org/10.2169/internalmedicine.0542-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262693PMC
November 2018
9 Reads

Lymphomatoid Granulomatosis with Isolated Cutaneous Lesions: Prolonged Remission After DA-EPOCH Protocol

Turk J Haematol 2018 08 1;35(3):213-214. Epub 2018 Jun 1.

All India Institute of Medical Sciences, Department of Medical Oncology, New Delhi, India

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http://dx.doi.org/10.4274/tjh.2018.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110445PMC
August 2018
20 Reads
0.340 Impact Factor

Cartilage hair hypoplasia with cutaneous lymphomatoid granulomatosis.

Clin Exp Dermatol 2018 Aug 10;43(6):713-717. Epub 2018 May 10.

Department of Pathology, Birmingham Children's Hospital, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia characterized by short-stature, sparse hair and impaired cellular immunity. We describe a young girl who was diagnosed with CHH based on the findings of recurrent infections, short stature with metaphyseal chondrodysplasia, and a confirmed bi-allelic RMRP gene mutation. At 13 years, the patient developed an Epstein-Barr virus (EBV)-driven lymphoproliferative disorder involving the lung, which responded partially to chemotherapy. Read More

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http://dx.doi.org/10.1111/ced.13543DOI Listing
August 2018
5 Reads

Angiocentric lymph proliferative disorder (lymphomatoid granulomatosis) in a person with newly-diagnosed HIV infection: a case report.

BMC Infect Dis 2018 05 8;18(1):210. Epub 2018 May 8.

Division of Infectious Diseases and Chronic Viral Illness Service, McGill University Health Centre, Royal Victoria Hospital, Glen Site, 1001 boulevard Decarie, Montreal, QC, H4A 3J1, Canada.

Background: Angiocentric lymph proliferative disorder (ALPD) is a granulomatous lymphoproliferative condition associated with various primary and secondary immunodeficiency states. ALPD is so rare that its prevalence has not been established. Typically affecting middle-aged adults, this condition is often found in the context of Epstein Bar Virus infection and consists of angiocentric and angioinvasive pulmonary infiltrates. Read More

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http://dx.doi.org/10.1186/s12879-018-3128-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941628PMC
May 2018
19 Reads

Primary pulmonary lymphoproliferative neoplasms.

Lung India 2018 May-Jun;35(3):220-230

Department of Internal Medicine, Divisions of Critical Care, Pulmonary and Sleep Medicine, UT Health- McGovern Medical School, Houston, Texas, USA.

Pulmonary lymphoproliferative neoplasms are rare lung tumors and account for <1% of all lung tumors. Among them, primary pulmonary lymphomas (PPL) constitute the majority, which include Non-Hodgkin's lymphoma (NHL) that comprise of mucosa-associated lymphoid tissue lymphoma, diffuse large B-cell lymphomas and other rare types of NHL and lymphomatoid granulomatosis. HL, which arises secondary to contiguous spread from the mediastinum, is the rarest type of PPL. Read More

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http://dx.doi.org/10.4103/lungindia.lungindia_381_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946555PMC
April 2018
25 Reads

Lymphomatoid granulomatosis: A case series from South India.

Indian J Pathol Microbiol 2018 Apr-Jun;61(2):228-232

Department of Pathology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.

Context: Lymphomatoid granulomatosis (LYG) is a rare B-lymphoproliferative disorder characterised by an angiocentric and angiodestructive pattern along with Epstein - Barr virus (EBV) association. It is one of the diagnostic challenges in lymphoma pathology. Deregulation of EBV immune surveillance is one of the narrated hypotheses in the literature. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_471_17DOI Listing
October 2018
369 Reads
0.642 Impact Factor

Primary lymphomatoid granulomatosis in the central nervous system: A report of three cases.

Neuropathology 2018 Apr 10. Epub 2018 Apr 10.

Department of Pathology, Seoul National University, College of Medicine, Seoul, Korea.

Lymphomatoid granulomatosis (LYG) is a rare lymphoproliferative disorder characterized by infiltration of Epstein-Barr virus (EBV)-positive large atypical B-cells in an angiocentric fashion in a mixed inflammatory background. The histologic spectrum of LYG ranges from reactive proliferation to diffuse large B-cell lymphoma according to the number of EBV+ B-cells. It is known that virtually all patients have pulmonary involvement, whereas primary LYG of the other organs has been rarely reported. Read More

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http://dx.doi.org/10.1111/neup.12467DOI Listing
April 2018
51 Reads

Oral Manifestation of Lymphomatoid Granulomatosis.

Head Neck Pathol 2019 Jun 14;13(2):270-276. Epub 2018 Mar 14.

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.

Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder driven by Esptein-Barr virus (EBV) that most commonly affects the lungs, although extra pulmonary sites like the central nervous system, skin, liver and kidney can also be involved. It is microscopically characterized by an angiocentric and angiodestructive growth pattern, predominantly composed by small T-cells, although a smaller population of atypical large B-cells is considered the true neoplastic component. Oral cavity involvement of LYG has rarely been described and the diagnosis of this neoplasm is very difficult. Read More

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http://dx.doi.org/10.1007/s12105-018-0910-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513961PMC
June 2019
19 Reads

EBV-Positive Lymphoproliferations of B- T- and NK-Cell Derivation in Non-Immunocompromised Hosts.

Pathogens 2018 Mar 7;7(1). Epub 2018 Mar 7.

Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, University Hospital Tübingen, Eberhard-Karls-University, 72076 Tübingen, Germany.

The contribution of Epstein-Barr virus (EBV) to the development of specific types of benign lymphoproliferations and malignant lymphomas has been extensively studied since the discovery of the virus over the last 50 years. The importance and better understanding of the EBV-associated lymphoproliferative disorders (LPD) of B, T or natural killer (NK) cell type has resulted in the recognition of new entities like EBV+ mucocutaneous ulcer or the addition of chronic active EBV (CAEBV) infection in the revised 2016 World Health Organization (WHO) lymphoma classification. In this article, we review the definitions, morphology, pathogenesis, and evolving concepts of the various EBV-associated disorders including EBV+ diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), EBV+ mucocutaneous ulcer, DLBCL associated with chronic inflammation, fibrin-associated DLBCL, lymphomatoid granulomatosis, the EBV+ T and NK-cell LPD of childhood, aggressive NK leukaemia, extranodal NK/T-cell lymphoma, nasal type, and the new provisional entity of primary EBV+ nodal T- or NK-cell lymphoma. Read More

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http://dx.doi.org/10.3390/pathogens7010028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874754PMC
March 2018
14 Reads

Lymphomatoid Granulomatosis in a 14-Year-Old Boy with Trisomy 21 and History of B-Lymphoblastic Leukemia/Lymphoma.

Fetal Pediatr Pathol 2018 Feb 16;37(1):7-14. Epub 2018 Jan 16.

a Department of Pathology, University of Utah , Salt Lake City , Utah , United States.

Background: Lymphomatoid granulomatosis is a EBV-driven lymphoproliferative disorder that has been reported in association with immunodeficiency, but only exceptionally in patients with hematopoietic malignancy.

Case Report: A 14-year-old boy with trisomy-21 and a history of B-lymphoblastic leukemia/lymphoma (B-ALL) diagnosed 1.5 years prior, on maintenance chemotherapy, presented with fever and respiratory symptoms. Read More

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http://dx.doi.org/10.1080/15513815.2017.1379042DOI Listing
February 2018
29 Reads

A surgical case of methotrexate-associated lymphomatoid granuloma.

Gen Thorac Cardiovasc Surg 2018 Jul 19;66(7):435-438. Epub 2017 Dec 19.

Division of Thoracic Surgery, Department of Surgery, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa, 259-1193, Japan.

We reported a surgical case of methotrexate-associated lymphomatoid granuloma. A 69-year-old female had been treated with methotrexate for rheumatoid arthritis for 35 months. The patient underwent partial resection of the right upper pulmonary lobe for lung cancer when she was 67 years old. Read More

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http://dx.doi.org/10.1007/s11748-017-0871-0DOI Listing
July 2018
18 Reads

A Case of Hodgkin Lymphoma Mimicking Lymphomatoid Granulomatosis Diagnosed at Autopsy.

Lab Med 2017 Dec;49(1):80-86

Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cinncinati, OH.

Hodgkin lymphoma and lymphomatoid granulomatosis (LYG) are entities that contain a small number of large, variably Epstein-Barr virus (EBV)-positive neoplastic cells scattered within background non-neoplastic mixed inflammatory infiltrate. The 2 entities can typically be distinguished histologically by the angiocentric and angiodestructive pattern of lymphomatoid granulomatosis (LYG); also, they differ in overall prognosis. Herein, we report a case of Hodgkin lymphoma in a 64-year-old Caucasian woman, diagnosed at autopsy with unusual histologic features and aggressive clinical course that mimicked LYG. Read More

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http://dx.doi.org/10.1093/labmed/lmx065DOI Listing
December 2017
12 Reads

Unsuspected lymphomatoid granulomatosis in a patient with antisynthetase syndrome.

Cutis 2017 Oct;100(4):E22-E26

Department of Dermatology, Department of Pathology, University of Michigan, Ann Arbor, USA.

Clinical diagnosis of lymphomatoid granulomatosis (LYG) often is difficult, especially in patients with multiple comorbidities. We present a 60-year-old woman with worsening fatigue, night sweats, unintentional weight loss, and dyspnea of 2 weeks' duration. Her medical history was remarkable for recent radiation therapy for recurrent breast cancer and antisynthetase syndrome complicated by interstitial lung disease and controlled with azathioprine. Read More

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October 2017
17 Reads

Cancer Therapy-associated Lymphoproliferative Disorders: An Under-recognized Type of Immunodeficiency-associated Lymphoproliferative Disorder.

Am J Surg Pathol 2018 Jan;42(1):116-129

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX.

We describe the clinicopathologic features of 17 patients who had a hematologic malignancy of various types, were treated, and subsequently developed a lymphoproliferative disorder (LPD). There were 10 men and 7 women with a median age of 59 years (range, 36 to 83 y). The primary hematologic neoplasms included: 5 chronic lymphocytic leukemia/small lymphocytic lymphoma, 3 plasma cell myeloma, 2 acute monoblastic leukemia, and 1 case each of mixed-phenotype acute leukemia, chronic myeloid leukemia, splenic marginal zone lymphoma, follicular lymphoma, mantle cell lymphoma, T-cell prolymphocytic leukemia, and peripheral T-cell lymphoma. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000954DOI Listing
January 2018
15 Reads